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https://www.readbyqxmd.com/read/29212544/plaque-volume-and-plaque-risk-profile-in-diabetic-vs-non-diabetic-patients-undergoing-lipid-lowering-therapy-a-study-based-on-3d-intravascular-ultrasound-and-virtual-histology
#1
Tomas Kovarnik, Zhi Chen, Gary S Mintz, Andreas Wahle, Kristyna Bayerova, Ales Kral, Martin Chval, Karel Kopriva, John Lopez, Milan Sonka, Ales Linhart
BACKGROUND: Coronary atherosclerosis progresses faster in patients with diabetes mellitus (DM) and causes higher morbidity and mortality in such patients compared to non-diabetics ones (non-DM). We quantify changes in plaque volume and plaque phenotype during lipid-lowering therapy in DM versus non-DM patients using advanced intracoronary imaging. METHODS: We analyzed data from 61 patients with stable angina pectoris included to the PREDICT trial searching for prediction of plaque changes during intensive lipid-lowering therapy (40 mg rosuvastatin daily)...
December 7, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29197606/elevated-plasma-levels-of-ldl-cholesterol-promote-dissecting-thoracic-aortic-aneurysms-in-angiotensin-ii-induced-mice
#2
Hiroki Tanaka, Yasunori Iida, Takayuki Iwaki, Yuko Suzuki, Hideto Sano, Chiharu Miyajima, Nobuhiro Zaima, Takeshi Sasaki, Ayato Sumioka, Shogo Hakamata, Hideyuki Shimizu, Kazuo Umemura, Tetsumei Urano
BACKGROUND: Plasma low-density lipoprotein (LDL)-cholesterol is implicated in aortic aneurysm (AA) and dissection (AD); however, its role in the pathogenesis of AA and AD, a disease with a high mortality rate, is unknown. The existing animal models such as apolipoprotein E-deficient (Apoe-/-) mice cannot reproduce all the conditions of AA/AD, including elevated LDL-cholesterol levels and spontaneous atheroma formation; therefore, a more reliable in vivo model is required. Here, we analyzed angiotensin II-induced mice with combined deficiency of the LDL receptor and the catalytic component of the apolipoprotein B-edisome complex (Ldlr-/-/Apobec1-/-) to understand AA formation and AD occurrence in relation to plasma lipid composition...
November 29, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29177549/different-infarction-patterns-in-patients-with-aortic-atheroma-compared-to-those-with-cardioembolism-or-large-artery-atherosclerosis
#3
Seung Woo Kim, Young Dae Kim, Hyuk-Jae Chang, Geu-Ru Hong, Chi Young Shim, Seok Jong Chung, Jin Yong Hong, Tae-Jin Song, Dongbeom Song, Oh Young Bang, Ji Hoe Heo, Hyo Suk Nam
Aortic atheroma is a known cause of ischemic stroke. However, it is unclear whether ischemic stroke is caused by emboli from aortic atheroma or by accompanying atherosclerosis. In this study, we evaluated lesion patterns of patients with complex aortic plaque (CAP) to assume the underlying pathophysiology. Acute ischemic stroke patients who underwent transesophageal echocardiography were included. CAP was defined as a plaque in the proximal aorta ≥ 4 mm thick or with a mobile component. The diffusion-weighted imaging lesion patterns of patients with CAP were compared to those with large arterial atherosclerosis (LAA) or cardioembolism (CE)...
November 24, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29174290/associations-of-mitral-and-aortic-valve-calcifications-with-complex-aortic-atheroma-in-patients-with-embolic-stroke-of-undetermined-source
#4
Kentaro Ishizuka, Takao Hoshino, Kyomi Ashihara, Kenji Mruyama, Sono Toi, Satoko Mizuno, Yuka Shirai, Nobuhisa Hagiwara, Kazuo Kitagawa
BACKGROUND: This study investigated the associations of mitral and aortic valve calcification with complex aortic atheroma among patients with embolic stroke of undetermined source. METHODS: We included 52 consecutive patients (mean age 58.1 years; 75.0% male) with embolic stroke of undetermined source. Mitral annular calcification, aortic annular calcification, and aortic valve sclerosis were assessed by transthoracic echocardiography. Complex aortic atheroma was assessed by transesophageal echocardiography and was defined as plaque protruding greater than or equal to 4 mm into the lumen or with ulcerated or mobile components...
November 21, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29159220/data-on-atherosclerosis-specific-antibody-conjugation-to-nanoemulsions
#5
Geoffrey Prévot, Martine Duonor-Cérutti, Mélusine Larivière, Jeanny Laroche-Traineau, Marie Josée Jacobin-Valat, Philippe Barthélémy, Gisèle Clofent-Sanchez, Sylvie Crauste-Manciet
This article present data related to the publication entitled "Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging" (Prévot et al., 2017) [1]. Herein we describe the engineering in the baculovirus-insect cell system and purification processes of the human scFv-Fc TEG4-2C antibody, specific of platelets within the atheroma plaque. For molecular targeting purpose, atheroma specific antibody was conjugated to nanoemulsions (NEs) using a heterobifunctional linker (DSPE-PEG-maleimide)...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29151984/hepatic-and-aortic-arch-expression-and-serum-levels-of-syndecan-1-in-apoe-mice
#6
Elena I Leonova, Elena S Sadovnikova, Elvira R Shaykhutdinova, Oxana V Galzitskaya, Arkady N Murashev, Alexandr S Solonin
Background: Heparan sulfate proteoglycan (HSPG) syndecan-1 (Sdc1) acts as a receptor for triglyceride-rich lipoproteins (TRLs), growth factors, chemokines and enzymes. Due to the disordered structure, its function is as diverse as its ligands. In this paper, we have analyzed hepatic and aortic arch expression of Sdc1 in ApoE(-/-) mice and examined their association with biochemical changes in plasma during the atheroma formation. Methods: ApoE knockout (ApoE(-/-)) mice as a model of atherosclerosis were used...
2017: Open Biochemistry Journal
https://www.readbyqxmd.com/read/29145149/sirt2-decreases-atherosclerotic-plaque-formation-in-low-density-lipoprotein-receptor-deficient-mice-by-modulating-macrophage-polarization
#7
BuChun Zhang, YanFeng Ma, ChuHan Xiang
Compelling evidence has demonstrated that the M1 macrophage phenotype is central to atherosclerotic lesion development. SIRT2, an NAD(+)-dependent sirtuin deacetylase, is involved in modulating macrophage polarization. However, the role of SIRT2 in atherosclerotic progression remains unknown. Female LDL receptor knockout (LDLr(-/-)) mice were randomly divided into four groups for treatment with saline, empty lentivirus, lentivirus-SIRT2, or shRNA-SIRT2 for 4 weeks. Thereafter, the mice were fed an atherogenic high-fat diet (HFD) for another 8 weeks...
November 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29139033/relationship-between-airflow-obstruction-and-coronary-atherosclerosis-in-asymptomatic-individuals-evaluation-by-coronary-ct-angiography
#8
Jin-Jin Kim, Dong-Bin Kim, Sung-Won Jang, Eun Joo Cho, Kiyuk Chang, Sang Hong Baek, Ho-Joong Youn, Wook Sung Chung, Ki-Bae Seung, Tai-Ho Rho, Jung Im Jung, Byung-Hee Hwang
Airflow obstruction is associated with increased cardiovascular morbidity and mortality. However, the causal mechanisms linking airflow obstruction with higher incidence of cardiovascular events remain elusive. We evaluated the relationship between airflow obstruction, a key feature of chronic obstructive pulmonary disease (COPD), and prevalence, extent, and severity of coronary atherosclerosis in a large cohort of asymptomatic subjects. Participants were recruited from those undergoing spirometry and coronary computed tomography angiography (CCTA) as part of a general health evaluation from March 2009 to February 2011...
November 14, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29118945/the-role-of-cholesterol-enriched-diet-and-paraoxonase-1-inhibition-in-atherosclerosis-progression
#9
Masoumeh Amani, Akbar Darbin, Masoud Pezeshkian, Abbas Afrasiabi, Naser Safaie, Ahmadreza Jodati, Masoud Darabi, Maghsod Shaaker, Zeinab Latifi, Amir Fattahi, Gholam-Hossein Farjah, Mohammad Nouri, Mohammad Hassan Khadem-Ansari
Introduction: Atherosclerosis could be deemed as a chronic, progressive, and inflammatory disease. It has been well-documented that high-density lipoprotein (HDL) can reduce the risk of the atherosclerosis occurrence through exerting some anti-atherogenic mechanisms. In recent years, the strong evidence has suggested that paraoxonase 1 (PON1) may contribute to antioxidant properties of HDL. In the present study, the impact of a diet enriched with cholesterol and also the PON1 inhibition on atheroma formation and lipid profile has been investigated...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/29112932/anti-atherosclerotic-effect-of-longxuetongluo-capsule-in-high-cholesterol-diet-induced-atherosclerosis-model-rats
#10
J M Zhou, H M Wang, Y Z Lv, Z Z Wang, W Xiao
Chinese dragon's blood, the red resin of Dracaena cochinchinensis, one of the famous traditional medicines, has been used to promote blood circulation, disperse blood stasis, stop bleeding, relieve pain and muscle regeneration for thousands of years. The aims of this study were to evaluate the anti-atherosclerotic effect of Longxuetongluo Capsule (LTC), which made by total phenolic compounds of Chinese dragon's blood, in high cholesterol diet (HCD)-induced atherosclerosis model rats and explore the possible mechanism...
November 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29110103/ct-imaging-of-the-vulnerable-plaque
#11
REVIEW
Gary R Small, Benjamin J W Chow
Acute coronary syndromes are most often the result of vulnerable atherosclerotic plaque events. Plaques events occur when intimal fibroatheroma in the coronary artery wall becomes vulnerable to erosion or rupture. Such vulnerable plaques can be distinguished from quiescent atheroma by features that have been defined through histopathology and invasive imaging. A challenge for coronary CT angiography has been to identify vulnerable plaques non-invasively. Were this possible, CT angiography could offer comprehensive vessel assessment including stenosis severity and plaque characteristics with the hope of reducing acute coronary events through timely intervention...
November 6, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29103013/palm-atheroma-infection-caused-by-raoultella-planticola
#12
Naoki Yoshida, Yoshihiko Tsuchida
No abstract text is available yet for this article.
November 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29096833/specific-lp-a-apheresis-a-tool-to-prove-lipoprotein-a-atherogenicity
#13
S N Pokrovsky, O I Afanasieva, M S Safarova, T V Balakhonova, Yu G Matchin, I Y U Adamova, G A Konovalov, M V Ezhov
BACKGROUND: An elevated lipoprotein(a) (Lp(a)) level is observed in more than 30% of patients with stable ischemic heart disease (SIHD). We conducted an investigation of the effects of specific Lp(a) apheresis on the progression of atherosclerosis in SIHD patients with Lp(a) levels greater than 50 mg/dL. METHODS: We prospectively enrolled 15 patients diagnosed with SIHD based on symptom-driven coronary angiography findings, with Lp(a) ≥50 mg/dL and a low density lipoprotein cholesterol (LDL-C) ≤2...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29093405/mycotic-aneurysm-mimicking-atheroma-in-aortic-arch
#14
Yueh-An Lu, Wen-Hung Huang, Tzung-Hai Yen, Ching-Wei Hsu
No abstract text is available yet for this article.
November 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29055633/colchicine-therapy-and-plaque-stabilization-in-patients-with-acute%C3%A2-coronary-syndrome-a-ct-coronary-angiography-study
#15
Kaivan Vaidya, Clare Arnott, Gonzalo J Martínez, Bernard Ng, Samuel McCormack, David R Sullivan, David S Celermajer, Sanjay Patel
OBJECTIVES: The authors sought to evaluate the plaque-modifying effects of low-dose colchicine therapy plus optimal medical therapy (OMT) in patients post-acute coronary syndrome (ACS), as assessed by coronary computed tomography angiography (coronary CTA). BACKGROUND: Colchicine therapy has been postulated to have beneficial anti-inflammatory effects in patients with ACS, translating into reduction in future adverse cardiovascular events. However, whether favorable plaque modification underpins this is yet unproven...
October 14, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29050738/-timma-ultrasonographic-scale-of-carotid-atherosclerosis-by-vascular-neurologists
#16
K Yayehd, N Morel, W Vadot, G Rodier, C Maugras, J Jund, L Belle, T Berremili
BACKGROUND: Carotid atherosclerosis is a powerful predictive factor of vascular risk at the individual patient level. Ultrasonography is a reference technique for the evaluation of this condition. However, its use in common practice remains difficult due to a lack of standardization and inter-operator variability. We present a new and simple technique for the assessment of carotid atherosclerosis; and evaluate the ability of vascular neurologists to obtain results consistent with those of an expert in vascular ultrasound...
November 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29045466/factors-predicting-cardiovascular-events-in-chronic-kidney-disease-patients-role-of-subclinical-atheromatosis-extent-assessed-by-vascular-ultrasound
#17
José M Valdivielso, Angels Betriu, Montserrat Martinez-Alonso, David Arroyo, Marcelino Bermudez-Lopez, Elvira Fernandez
Patients with chronic kidney disease (CKD) have an increased incidence of cardiovascular events (CVE). The contribution of subclinical atheromatosis extent, including femoral arteries, to CVE in CKD patients has not been investigated. In this paper, we examine the prognostic value of subclinical atheromatosis extent, assessed as the number of arterial territories with plaque, in predicting the incidence of major and minor CVE. The NEFRONA is a multicenter, prospective cohorts study that recruited 2445 CKD subjects and 559 controls, free from previous cardiovascular disease, in 81 medical centers across Spain...
2017: PloS One
https://www.readbyqxmd.com/read/29040971/characteristics-and-outcomes-of-vertebrobasilar-artery-dissection-with-accompanied-atherosclerosis
#18
Chun Chien, Feng-Chi Chang, Hui-Chi Huang, Jui-Yao Tsai, Chih-Ping Chung
BACKGROUND: With the popularity of MRI use, vertebrobasilar artery dissection (VBD) has been found more frequently in patients with posterior circulation ischemic stroke (PCS). The relationship between VBD and atherosclerosis is unknown. The present study aimed to prove the hypothesis that PCS with pure VBD (p-VBD) and with VBD and accompanied cervical or cerebral artery atherosclerosis (a-VBD) have distinct manifestations. METHODS: Patients with VBD-related PCS who were prospectively enrolled in the Taipei Veterans General Hospital Stroke Registry between January 1, 2010 and August 31, 2014 were recruited for the present study...
October 17, 2017: Cerebrovascular Diseases Extra
https://www.readbyqxmd.com/read/29025936/complete-genome-sequence-of-super-biofilm-elaborating-staphylococcus-aureus-isolated-in-japan
#19
Liansheng Yu, Junzo Hisatsune, Hideki Hirakawa, Emiri Mizumachi, Atsushi Toyoda, Koji Yahara, Motoyuki Sugai
Staphylococcus aureus JP080, previously named TF2758, is a clinical isolate from an atheroma and a super biofilm-elaborating strain whose biofilm elaboration is dependent solely on polysaccharide poly-N-acetylglucosamine/polysaccharide intercellular adhesin (PNAG/PIA). Here, we report the complete genome sequence of strain JP080, which consists of one chromosome and one circular plasmid.
October 12, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29016728/augmented-th17-differentiation-in-trim21-deficiency-promotes-a-stable-phenotype-of-atherosclerotic-plaques-with-high-collagen-content
#20
Susanna Brauner, Xintong Jiang, Gudny Ella Thorlacius, Anna M Lundberg, Therese Östberg, Zhong-Qun Yan, Vijay K Kuchroo, Göran K Hansson, Marie Wahren-Herlenius
Aims: Patients with hyperlipidemia are at risk of atherosclerosis, but not all develop cardiovascular disease, highlighting the importance of other risk factors such as inflammation. Both the innate and adaptive arms of the immune system have been suggested in the initiation and propagation of plaque formation. Tri-partite motif (TRIM) 21 is a regulator of tissue inflammation and pro-inflammatory cytokine production, and has been implicated in chronic inflammatory disease. Here, we investigate a potential role for TRIM21 in coronary artery disease...
September 4, 2017: Cardiovascular Research
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