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https://www.readbyqxmd.com/read/29025936/complete-genome-sequence-of-super-biofilm-elaborating-staphylococcus-aureus-isolated-in-japan
#1
Liansheng Yu, Junzo Hisatsune, Hideki Hirakawa, Emiri Mizumachi, Atsushi Toyoda, Koji Yahara, Motoyuki Sugai
Staphylococcus aureus JP080, previously named TF2758, is a clinical isolate from an atheroma and a super biofilm-elaborating strain whose biofilm elaboration is dependent solely on polysaccharide poly-N-acetylglucosamine/polysaccharide intercellular adhesin (PNAG/PIA). Here, we report the complete genome sequence of strain JP080, which consists of one chromosome and one circular plasmid.
October 12, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29016728/augmented-th17-differentiation-in-trim21-deficiency-promotes-a-stable-phenotype-of-atherosclerotic-plaques-with-high-collagen-content
#2
Susanna Brauner, Xintong Jiang, Gudny Ella Thorlacius, Anna M Lundberg, Therese Östberg, Zhong-Qun Yan, Vijay K Kuchroo, Göran K Hansson, Marie Wahren-Herlenius
Aims: Patients with hyperlipidemia are at risk of atherosclerosis, but not all develop cardiovascular disease, highlighting the importance of other risk factors such as inflammation. Both the innate and adaptive arms of the immune system have been suggested in the initiation and propagation of plaque formation. Tri-partite motif (TRIM) 21 is a regulator of tissue inflammation and pro-inflammatory cytokine production, and has been implicated in chronic inflammatory disease. Here, we investigate a potential role for TRIM21 in coronary artery disease...
September 4, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28966320/association-of-dyslipidemia-and-sex-with-coronary-artery-calcium-assessed-by-coronary-computed-tomography-angiography
#3
Masahiko Asami, Kyohei Yamaji, Jiro Aoki, Shuzou Tanimoto, Mika Watanabe, Yu Horiuchi, Koichi Furui, Nahoko Kato, Kazuhiro Hara, Kengo Tanabe
Previous studies reporting that statin increases coronary artery calcium (CAC) were conducted exclusively on patients with statin as a prevention, regardless of the presence or absence of dyslipidemia. The impact of sex on CAC has not been fully evaluated. We aimed to determine the association of dyslipidemia and sex with CAC using 320-row multi-detector computed tomography (MDCT).Of the 356 consecutive patients who underwent coronary MDCT, 251 patients were enrolled, after excluding those with prior stenting and/or coronary bypass grafting or images showing motion artifacts...
September 30, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28952472/-cardiovascular-prevention-and-pitavastatin
#4
Meral Kayıkçıoğlu
HMG-CoA reductase inhibitors (statins) represent the most effective class of LDL lowering drugs with an overall positive safety and tolerability profile. They have also consistent benefit in terms of reduced cardiovascular (CV) events in both primary and secondary prevention. Pitavastatin is a new member of the statin class. This review provides a current overview of pravastatin's role in CV risk reduction. In brief pitatastatin has pleitrophic effects as the other statins. It has been shown that it reduces plaque atheroma volume in acute coranary settings...
April 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28930197/red-blood-cell-eicosapentaenoic-acid-inversely-relates-to-mri-assessed-carotid-plaque-lipid-core-burden-in-elders-at-high-cardiovascular-risk
#5
Núria Bargalló, Rosa Gilabert, Edwin-Saúl Romero-Mamani, Montserrat Cofán, Philip C Calder, Montserrat Fitó, Dolores Corella, Jordi Salas-Salvadó, Miguel Ruiz-Canela, Ramon Estruch, Emilio Ros, Aleix Sala-Vila
Supplemental marine omega-3 eicosapentaenoic acid (EPA) has an anti-atherosclerotic effect. Clinical research on EPA supplied by the regular diet and atherosclerosis is scarce. In the framework of the PREvención con DIeta MEDiterránea (PREDIMED) trial, we conducted a cross-sectional study in 161 older individuals at high vascular risk grouped into different stages of carotid atherosclerosis severity, including those without ultrasound-detected atheroma plaque (n = 38), with plaques <2.0 mm thick (n = 65), and with plaques ≥2...
September 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28924075/edoxaban-enhances-thromboprophylaxis-by-physiotherapy-after-total-knee-arthroplasty%C3%A3-the-randomized-controlled-escort-tka-trial
#6
Daisuke Sueta, Koichi Kaikita, Nobukazu Okamoto, Soichiro Yamabe, Masanobu Ishii, Yuichiro Arima, Miwa Ito, Yu Oimatsu, Tatsuro Mitsuse, Satomi Iwashita, Eiichi Nakamura, Seiji Hokimoto, Hiroshi Mizuta, Hisao Ogawa, Kenichi Tsujita
BACKGROUND: The pharmacological advantage of combining physiotherapy with anticoagulants for the prevention of venous thromboembolism (VTE) after total knee arthroplasty (TKA) is not fully known. Herein we investigated the potential benefit of this combination therapy in patients undergoing TKA.Methods and Results:The 38 patients were randomly assigned to a physiotherapy group (n=19) or a physiotherapy plus 30 mg/day edoxaban group (n=19). The occurrence of VTE was evaluated, as were serial changes in parameters measured by the Total Thrombus-formation Analysis System, a novel system for quantitatively analyzing thrombus formation using microchips with thrombogenic surfaces (collagen plus tissue factor, atheroma [AR]-chip)...
September 16, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28899764/iron-oxide-core-oil-in-water-nanoemulsion-as-tracer-for-atherosclerosis-mpi-and-mri-imaging
#7
Geoffrey Prévot, Tina Kauss, Cyril Lorenzato, Alexandra Gaubert, Mélusine Larivière, Julie Baillet, Jeanny Laroche-Traineau, Marie Josée Jacobin-Valat, Laurent Adumeau, Stéphane Mornet, Philippe Barthélémy, Martine Duonor-Cérutti, Gisèle Clofent-Sanchez, Sylvie Crauste-Manciet
PURPOSE: For early atherosclerosis imaging, magnetic oil-in-water nanoemulsion (NE) decorated with atheroma specific monoclonal antibody was designed for Magnetic Particle Imaging (MPI) and Magnetic Resonance Imaging (MRI). MPI is an emerging technique based on direct mapping of superparamagnetic nanoparticles which may advantageously complement MRI. METHODS: NE oily droplets were loaded with superparamagnetic iron oxide nanoparticles of 7, 11 and 18nm and biofunctionalized with atheroma specific scFv-Fc TEG4-2C antibody...
November 5, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28891324/relationship-between-monocyte-to-lymphocyte-ratio-and-coronary-plaque-vulnerability-in-patients-with-stable-angina
#8
Zeyuan Fan, Hanhua Ji, Yang Li, Xinwen Jian, Li Li, Tao Liu
AIM: To investigate the relationship between monocyte-to-lymphocyte ratio (MLR) and plaque vulnerability assessed by virtual histology intravascular ultrasound in patients with stable angina. METHODS: 133 patients with stable angina were enrolled. RESULTS: MLR was found to be an independent risk factor of thin cap fibrous atheroma (OR: 2.61; p = 0.025). MLR could differentiate thin cap fibrous atheroma with a sensitivity of 73.7% and a specificity of 61...
September 11, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28886156/loss-of-sprr3-in-apoe-mice-leads-to-atheroma-vulnerability-through-akt-dependent-and-independent-effects-in-vsmcs
#9
Caressa D Lietman, Amanda K Segedy, Bin Li, Sergio Fazio, James B Atkinson, MacRae F Linton, Pampee P Young
Vascular smooth muscle cells (VSMCs) represent important modulators of plaque stability in advanced lesions. We previously reported that loss of small proline-rich repeat protein 3 (Sprr3), leads to VSMC apoptosis in a PI3K/Akt-dependent manner and accelerates lesion progression. Here, we investigated the role of Sprr3 in modulating plaque stability in hyperlipidemic ApoE-/- mice. We show that loss of Sprr3 increased necrotic core size and reduced cap collagen content of atheromas in brachiocephalic arteries with evidence of plaque rupture and development of intraluminal thrombi...
2017: PloS One
https://www.readbyqxmd.com/read/28883714/vascular-aging-and-subclinical-atherosclerosis-why-such-a-never-ending-and-challenging-story-in-cardiology
#10
EDITORIAL
Stela Iurciuc, Anca Maria Cimpean, Florin Mitu, Rodica Heredea, Mircea Iurciuc
The true onset of atherosclerosis remains one of the biggest challenges for cardiologists. Is atheroma plaque development considered the earliest step of vascular aging? If so, when it starts? Before or after birth? If it starts before birth or early during childhood, it seems that Thomas Sydenham was right: "A man is as old as his arteries." Except disorganization of elastic fibers, less is known about the morphology of vascular aging and also about the molecular events influencing the age of arteries, arterial stiffness, and their role in the appearance of future complications...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28877718/aortic-atheroma-as-a-source-of-stroke-assessment-of-embolization-risk-using-3d-cmr-in-stroke-patients-and-controls
#11
Thomas Wehrum, Iulius Dragonu, Christoph Strecker, Florian Schuchardt, Anja Hennemuth, Johann Drexl, Thomas Reinhard, Daniel Böhringer, Werner Vach, Jürgen Hennig, Andreas Harloff
BACKGROUND: It was our purpose to identify vulnerable plaques in the thoracic aorta using 3D multi-contrast CMR and estimate the risk of cerebral embolization using 4D flow CMR in cryptogenic stroke patients and controls. METHODS: One hundred patients (40 with cryptogenic stroke, 60 ophthalmologic controls matched for age, sex and presence of hypertension) underwent a novel 3D multi-contrast (T1w, T2w, PDw) CMR protocol at 3 Tesla for plaque detection and characterization within the thoracic aorta, which was combined with 4D flow CMR for mapping potential embolization pathways...
September 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28869155/investigation-of-chlamydia-pneumoniae-infection-in-moroccan-patients-suffering-from-cardiovascular-diseases
#12
Loubna El Yazouli, Hicham Hejaji, Naima Elmdaghri, Aziz Aroussi Alami, Nadia Dakka, Fouzia Radouani
Chlamydia pneumoniae is an intracellular bacterium responsible for respiratory diseases and is highly involved in cardiovascular disease development, mainly atherosclerosis. The main objective of our study was to evaluate C. pneumoniae prevalence in Moroccan patients suffering from cardiovascular diseases. A total of 115 patients with cardiovascular diseases were enrolled, and their clinical and behavioral information was recorded. Blood was sampled from all patients as well as the atheroma plaques from 36 patients undergoing surgery...
August 28, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28863874/a-randomized-controlled-trial-of-eicosapentaenoic-acid-in-patients-with-coronary-heart-disease-on-statins
#13
Tetsu Watanabe, Kaoru Ando, Hyuma Daidoji, Yoichiro Otaki, Shigeo Sugawara, Motoyuki Matsui, Eiichiro Ikeno, Osamu Hirono, Hiroshi Miyawaki, Yoshinori Yashiro, Satoshi Nishiyama, Takanori Arimoto, Hiroki Takahashi, Tetsuro Shishido, Takehiko Miyashita, Takuya Miyamoto, Isao Kubota
BACKGROUND: There is a residual risk of coronary heart disease (CHD) despite intensive statin therapy for secondary prevention. The aim of this study was to investigate whether coronary plaque regression and stabilization are reinforced by the addition of eicosapentaenoic acid (EPA) to high-dose pitavastatin (PTV). METHODS: We enrolled 193 CHD patients who underwent percutaneous coronary intervention (PCI) in six hospitals. Patients were randomly allocated to the PTV group (PTV 4mg/day, n=96) or PTV/EPA group (PTV 4mg/day and EPA 1800mg/day, n=97), and prospectively followed for 6-8 months...
August 29, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28846060/in-vivo-visualization-of-lipid-coronary-atheroma-with-intravascular-near-infrared-spectroscopy
#14
Yu Kataoka, Rishi Puri, Jordan Andrews, Satoshi Honda, Kensaku Nishihira, Yasuhide Asaumi, Teruo Noguchi, Satoshi Yasuda, Stephen J Nicholls
Atherosclerotic cardiovascular disease (ASCVD) has become a major health burden and is expected to further increase in the future. Better predictive approaches for ASCVD and more efficacious therapies are required to further improve cardiovascular outcomes. Intravascular imaging has contributed to the elucidation of atherosclerotic mechanisms and evaluation of novel therapies. Near-infrared spectroscopy has enabled the visualization of the lipid extent of atherosclerotic plaques in vivo. Given that lipid accumulation is considered to promote the formation and progression of atherosclerosis, this technology may harbor the potential to identify subjects with high cardiovascular risks and thus adopt more optimized therapeutic approaches...
August 28, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28829900/analysis-of-p53-gene-polymorphism-codon-72-in-symptomatic-patients-with-atherosclerosis
#15
M H Lagares, K S F Silva, A M Barbosa, D A Rodrigues, I R Costa, J V M Martins, M P Morais, F L Campedelli, K K V O Moura
Atherosclerosis is a multifactorial pathological disease that alters the morphology and function of arterial walls. The atheroma growth leads to vessel hardening and lumen narrowing, limiting the blood flow. The atheroma plaque can eventually break, expose highly thrombogenic material and lead to platelet activation and subsequent formation of a thrombus that may block blood flow in loco, or even leading to obstruction of other vessels with a smaller diameter. This process is one of the main determinants of the clinical manifestations of atherosclerosis, such as coronary artery disease, ischemic stroke, and peripheral arterial disease...
August 17, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28790269/-brain-protection-for-shaggy-aorta-during-aortic-arch-surgery
#16
Kenji Okada
Although short and long-term outcomes of aortic surgeries have been improving over the past decade, the procedure is likely to be asscociated with life-threatening complications such as neurological deficits caused by suboptimal brain protection or heavily diseased aorta. Contemporary strategies for brain protection are deep hypothermic arrest with or without retrograde cerebral perfusion retrograde cerebral perfusion or selective antegrade cerebral perfusion. At the moment, majority of evidences failed to show the superiority of selective antegrade cerebral perfusion to retrograde one...
July 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28768751/loss-of-y-chromosome-in-blood-is-associated-with-major-cardiovascular-events-during-follow-up-in-men-after-carotid-endarterectomy
#17
Saskia Haitjema, Daniel Kofink, Jessica van Setten, Sander W van der Laan, Arjan H Schoneveld, James Eales, Maciej Tomaszewski, Saskia C A de Jager, Gerard Pasterkamp, Folkert W Asselbergs, Hester M den Ruijter
BACKGROUND: Recent studies found an immune regulatory role for Y chromosome and a relationship between loss of Y chromosome (LOY) in blood cells and a higher risk of cancer and mortality. Given involvement of immune cells in atherosclerosis, we hypothesized that LOY is associated with the severity of atherosclerotic plaque characteristics and outcome in men undergoing carotid endarterectomy. METHODS AND RESULTS: LOY was quantified in blood and plaque from raw intensity genotyping data in men within the Athero-Express biobank study...
August 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28765529/intracoronary-imaging-cholesterol-efflux-and-transcriptomics-after-intensive-statin-treatment-in-diabetes
#18
Surbhi Chamaria, Kipp W Johnson, Yuliya Vengrenyuk, Usman Baber, Khader Shameer, Aparna A Divaraniya, Benjamin S Glicksberg, Li Li, Samit Bhatheja, Pedro Moreno, Akiko Maehara, Roxana Mehran, Joel T Dudley, Jagat Narula, Samin K Sharma, Annapoorna S Kini
Residual atherothrombotic risk remains higher in patients with versus without diabetes mellitus (DM) despite statin therapy. The underlying mechanisms are unclear. This is a retrospective post-hoc analysis of the YELLOW II trial, comparing patients with and without DM (non-DM) who received rosuvastatin 40 mg for 8-12 weeks and underwent intracoronary multimodality imaging of an obstructive nonculprit lesion, before and after therapy. In addition, blood samples were drawn to assess cholesterol efflux capacity (CEC) and changes in gene expression in peripheral blood mononuclear cells (PBMC)...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28764262/relationship-between-automated-coronary-calcium-volumes-and-a-set-of-manual-coronary-lumen-volume-vessel-volume-and-atheroma-volume-in-japanese-diabetic-cohort
#19
Sumit K Banchhor, Narendra D Londhe, Luca Saba, Petia Radeva, John R Laird, Jasjit S Suri
INTRODUCTION: A high degree of correlation exists between Coronary Artery Diseases (CAD) and calcification of the vessel wall. For Percutaneous Coronary Interventional (PCI) planning, it is essential to have an exact understanding of the extent to which calcium volume is correlated to the lumen, vessel, and atheroma volume regions in the coronary artery, which is unclear in recent studies. AIM: Four automated Coronary Calcium Volume (aCCV) measurement methods {threshold, Fuzzy c-Means (FCM), K-means, and Hidden Markov Random Field (HMRF)} and its correlation with three manual (experts) coronary parameters namely: Coronary Vessel Volume (mCVV), Coronary Lumen Volume (mCLV), and Coronary Atheroma Volume (mCAV), was determined in a Japanese diabetic cohort...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28756957/comparison-of-the-diameters-of-the-major-epicardial-coronary-arteries-by-angiogram-in-asian-indians-versus-european-americans-40-years-of-age-undergoing-percutaneous-coronary-artery-intervention
#20
COMPARATIVE STUDY
Amgad N Makaryus, Rajiv Jauhar, Leanne M Tortez, Renee Pekmezaris
Coronary artery disease (CAD) rates are higher in Asian-Indians than in Caucasians. CAD occurs at an earlier age in this group, with about a quarter of all myocardial infarctions occurring under the age of 40. Previous reports have suggested smaller coronary artery size in Asian-Indians as a major cause for increased CAD in this population. This study sought to evaluate the size of normal "atheroma-free" segments of the epicardial coronary arteries in Asian-Indians and Caucasians aged ≤40 years undergoing coronary artery intervention in other diseased segments...
September 15, 2017: American Journal of Cardiology
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