keyword
MENU ▼
Read by QxMD icon Read
search

atheroma

keyword
https://www.readbyqxmd.com/read/28790269/-brain-protection-for-shaggy-aorta-during-aortic-arch-surgery
#1
Kenji Okada
Although short and long-term outcomes of aortic surgeries have been improving over the past decade, the procedure is likely to be asscociated with life-threatening complications such as neurological deficits caused by suboptimal brain protection or heavily diseased aorta. Contemporary strategies for brain protection are deep hypothermic arrest with or without retrograde cerebral perfusion retrograde cerebral perfusion or selective antegrade cerebral perfusion. At the moment, majority of evidences failed to show the superiority of selective antegrade cerebral perfusion to retrograde one...
July 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28768751/loss-of-y-chromosome-in-blood-is-associated-with-major-cardiovascular-events-during-follow-up-in-men-after-carotid-endarterectomy
#2
Saskia Haitjema, Daniel Kofink, Jessica van Setten, Sander W van der Laan, Arjan H Schoneveld, James Eales, Maciej Tomaszewski, Saskia C A de Jager, Gerard Pasterkamp, Folkert W Asselbergs, Hester M den Ruijter
BACKGROUND: Recent studies found an immune regulatory role for Y chromosome and a relationship between loss of Y chromosome (LOY) in blood cells and a higher risk of cancer and mortality. Given involvement of immune cells in atherosclerosis, we hypothesized that LOY is associated with the severity of atherosclerotic plaque characteristics and outcome in men undergoing carotid endarterectomy. METHODS AND RESULTS: LOY was quantified in blood and plaque from raw intensity genotyping data in men within the Athero-Express biobank study...
August 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28765529/intracoronary-imaging-cholesterol-efflux-and-transcriptomics-after-intensive-statin-treatment-in-diabetes
#3
Surbhi Chamaria, Kipp W Johnson, Yuliya Vengrenyuk, Usman Baber, Khader Shameer, Aparna A Divaraniya, Benjamin S Glicksberg, Li Li, Samit Bhatheja, Pedro Moreno, Akiko Maehara, Roxana Mehran, Joel T Dudley, Jagat Narula, Samin K Sharma, Annapoorna S Kini
Residual atherothrombotic risk remains higher in patients with versus without diabetes mellitus (DM) despite statin therapy. The underlying mechanisms are unclear. This is a retrospective post-hoc analysis of the YELLOW II trial, comparing patients with and without DM (non-DM) who received rosuvastatin 40 mg for 8-12 weeks and underwent intracoronary multimodality imaging of an obstructive nonculprit lesion, before and after therapy. In addition, blood samples were drawn to assess cholesterol efflux capacity (CEC) and changes in gene expression in peripheral blood mononuclear cells (PBMC)...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28764262/relationship-between-automated-coronary-calcium-volumes-and-a-set-of-manual-coronary-lumen-volume-vessel-volume-and-atheroma-volume-in-japanese-diabetic-cohort
#4
Sumit K Banchhor, Narendra D Londhe, Luca Saba, Petia Radeva, John R Laird, Jasjit S Suri
INTRODUCTION: A high degree of correlation exists between Coronary Artery Diseases (CAD) and calcification of the vessel wall. For Percutaneous Coronary Interventional (PCI) planning, it is essential to have an exact understanding of the extent to which calcium volume is correlated to the lumen, vessel, and atheroma volume regions in the coronary artery, which is unclear in recent studies. AIM: Four automated Coronary Calcium Volume (aCCV) measurement methods {threshold, Fuzzy c-Means (FCM), K-means, and Hidden Markov Random Field (HMRF)} and its correlation with three manual (experts) coronary parameters namely: Coronary Vessel Volume (mCVV), Coronary Lumen Volume (mCLV), and Coronary Atheroma Volume (mCAV), was determined in a Japanese diabetic cohort...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28756957/comparison-of-the-diameters-of-the-major-epicardial-coronary-arteries-by-angiogram-in-asian-indians-versus-european-americans-40-years-of-age-undergoing-percutaneous-coronary-artery-intervention
#5
Amgad N Makaryus, Rajiv Jauhar, Leanne M Tortez, Renee Pekmezaris
Coronary artery disease (CAD) rates are higher in Asian-Indians than in Caucasians. CAD occurs at an earlier age in this group, with about a quarter of all myocardial infarctions occurring under the age of 40. Previous reports have suggested smaller coronary artery size in Asian-Indians as a major cause for increased CAD in this population. This study sought to evaluate the size of normal "atheroma-free" segments of the epicardial coronary arteries in Asian-Indians and Caucasians aged ≤40 years undergoing coronary artery intervention in other diseased segments...
June 29, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28756533/long-term-spironolactone-treatment-reduces-coronary-trpc-expression-vasoconstriction-and-atherosclerosis-in-metabolic-syndrome-pigs
#6
Wennan Li, Xingjuan Chen, Ashley M Riley, S Christopher Hiett, Constance J Temm, Eleni Beli, Xin Long, Saikat Chakraborty, Mouhamad Alloosh, Fletcher A White, Maria B Grant, Michael Sturek, Alexander G Obukhov
Coronary transient receptor potential canonical (TRPC) channel expression is elevated in metabolic syndrome (MetS). However, differential contribution of TRPCs to coronary pathology in MetS is not fully elucidated. We investigated the roles of TRPC1 and TRPC6 isoforms in coronary arteries of MetS pigs and determined whether long-term treatment with a mineralocorticoid receptor inhibitor, spironolactone, attenuates coronary TRPC expression and associated dysfunctions. MetS coronary arteries exhibited significant atherosclerosis, endothelial dysfunction, and increased histamine-induced contractions...
September 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28750634/preclinical-carotid-atherosclerosis-in-patients-with-latent-autoimmune-diabetes-in-adults-lada-type-2-diabetes-and-classical-type-1-diabetes
#7
Marta Hernández, Carolina López, Jordi Real, Joan Valls, Emilio Ortega-Martinez de Victoria, Federico Vázquez, Esther Rubinat, Minerva Granado-Casas, Nuria Alonso, Teresa Molí, Angels Betriu, Albert Lecube, Elvira Fernández, Richard David Leslie, Dídac Mauricio
BACKGROUND: LADA is probably the most prevalent form of autoimmune diabetes. Nevertheless, there are few data about cardiovascular disease in this group of patients. The aim of this study was to investigate the frequency of carotid atherosclerotic plaques in patients with LADA as compared with patients with classic type 1 diabetes and type 2 diabetes. METHODS: Patients with LADA were matched for age and gender in different proportions to patients with type 2 diabetes, and classic type 1 diabetes...
July 28, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28746820/the-role-of-damps-and-pamps-in-inflammation-mediated-vulnerability-of-atherosclerotic-plaques
#8
Vikrant Rai, Devendra K Agrawal
Atherosclerosis is a chronic inflammatory disease resulting in the formation of the atherosclerotic plaque. Plaque formation starts with the inflammation in fatty streak and progress through atheroma, atheromatous plaque, and fibroatheroma leading to development of stable plaque. Hypercholesterolemia, dyslipidemia, hyperglycemia are the risk factors for atherosclerosis. Inflammation, infection with viruses and bacteria, and dysregulation in the endothelial and vascular smooth muscle cells leads to advanced plaque formation...
July 26, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28746591/the-therapeutic-challenge-of-giant-splenic-artery-aneurysm-a-case-repport
#9
Paulo Kauffman, Antonio Luiz de Vasconcellos Macedo, Roberto Sacilotto, Adriano Tachibana, Sergio Kuzniec, Lucas Lembrança Pinheiro, Nelson Wolosker
Giant splenic artery aneurysm is a rare condition that represents an eminent life threatening for the patient, requiring, therefore, urgent surgical correction. A 61-year-old woman, former smoker, hypertensive, hypercholesterolemic and multipara sought our service because of a large tumor in the mesogastrium, which was an abdominal ultrasound finding. Despite the size of the tumor, the patient was asymptomatic. The angiotomography and the magnetic resonance image of the abdomen were suggestive of giant splenic artery aneurysm with more than 10cm in diameter that was confirmed by an angiography...
July 24, 2017: Einstein
https://www.readbyqxmd.com/read/28739184/carotid-plaque-instability-is-not-related-to-quantity-but-to-elemental-composition-of-calcification
#10
S Bischetti, M Scimeca, E Bonanno, M Federici, L Anemona, R Menghini, S Casella, M Cardellini, A Ippoliti, A Mauriello
BACKGROUND AND AIMS: Recent studies highlighted the role of calcification processes in the clinical progression of chronic cardiovascular diseases. In this study we investigated the relationship between the chemical composition of calcification and atherosclerotic plaque stability in carotid arteries. METHODS AND RESULTS: To this end, we characterized the calcification on 229 carotid plaques, by morphology, immunohistochemistry, transmission electron microscopy and energy dispersive X-ray microanalysis...
May 31, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28738590/extracellular-matrix-characterization-in-plaques-from-carotid-endarterectomy-by-a-proteomics-approach
#11
N Ucciferri, S Rocchiccioli, L Comelli, M Marconi, M Ferrari, G Pelosi, A Cecchettini
Extracellular matrix (ECM) is a fundamental component of multicellular organisms. Alteration of its structure and/or molecular composition are associated with several pathologies, among the others with atherosclerosis. To determine how the overall ECM architecture of a tissue as complex as the atheroma may change under varying pathological conditions constitutes a great technical challenge. This entails removing cell components and solubilisation of fibrillar proteins in order to allow enzymatic digestion and mass spectrometry analyses...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28735349/connecting-the-dots-between-fatty-acids-mitochondrial-function-and-dna-methylation-in-atherosclerosis
#12
REVIEW
Silvio Zaina, Gertrud Lund
PURPOSE OF REVIEW: The quest for factors and mechanisms responsible for aberrant DNA methylation in human disease-including atherosclerosis-is a promising area of research. This review focuses on the role of fatty acids (FAs) as modulators of DNA methylation-in particular the role of mitochondrial beta-oxidation in FA-induced changes in DNA methylation during the progression of atherosclerosis. RECENT FINDINGS: Recent publications have advanced the knowledge in all areas touched by this review: the causal role of lipids in shaping the DNA methylome, the associations between chronic degenerative disease and mitochondrial function, the lipid composition of the atheroma, and the relevance of DNA hypermethylation in atherosclerosis...
September 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28734922/warfarin-use-is-associated-with-progressive-coronary-arterial-calcification-insights-from-serial-intravascular-ultrasound
#13
Jordan Andrews, Peter J Psaltis, Ozgur Bayturan, Mingyuan Shao, Brian Stegman, Mohamed Elshazly, Samir R Kapadia, E Murat Tuzcu, Steven E Nissen, Stephen J Nicholls, Rishi Puri
OBJECTIVES: This study compared serial changes in coronary percent atheroma volume (PAV) and calcium index (CaI) in patients with coronary artery disease who were treated with and without warfarin. BACKGROUND: Warfarin blocks the synthesis and activity of matrix Gla protein, a vitamin K-dependent inhibitor of arterial calcification. The longitudinal impact of warfarin on serial coronary artery calcification in vivo in humans is unknown. METHODS: In a post hoc patient-level analysis of 8 prospective randomized trials using serial coronary intravascular ultrasound examinations, this study compared changes in PAV and CaI in matched arterial segments in patients with coronary artery disease who were treated with (n = 171) and without (n = 4,129) warfarin during an 18- to 24-month period...
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28726431/-what-has-the-glagov-clinical-study-shown
#14
Ján Murín
If we want to favorably influence the cardiovascular atherosclerotic disease, it is necessary to significantly lower LDL-C blood levels. PCSK9 inhibitors can significantly reduce LDL-cholesterol levels, being administered together with statins. However we focus on establishing whether this plays a role in influencing coronary atherosclerosis. The GLAGOV study is a multicentric, double-blinded and placebo-controlled study which during a 76-week period followed an impact of the treatment with evolocumab (PCSK9i) together with statin on the status of coronary atherosclerosis in patients with ischemic heart disease, and in comparison with the statin treatment...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28716557/is-the-score-chart-underestimating-the-real-cardiovascular-cv-risk-of-patients-with-psoriatic-arthritis-prevalence-of-subclinical-cv-disease-detected-by-carotid-ultrasound
#15
María Paz Martínez-Vidal, Cristina Fernández-Carballido
OBJECTIVES: To analyse the cardiovascular risk according to the SCORE chart in a series of patients with psoriatic arthritis, and to study the presence of subclinical cardiovascular disease by carotid ultrasound. METHODS: Cross-sectional descriptive study of patients with psoriatic arthritis attended in a tertiary hospital. The presence of classical cardiovascular risk factors and the clinical characteristics of the patients were recorded. The cardiovascular risk was calculated with SCORE, calibrated for Spain...
July 14, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28716089/greater-periventricular-white-matter-hyperintensity-severity-in-basilar-artery-branch-atheromatous-disease
#16
Po-Chen Lin, Feng-Chi Chang, Hui-Chi Huang, Jui-Yao Tsai, Yung-Yang Lin, Chih-Ping Chung
BACKGROUND: Basilar artery branch atheromatous disease (BABAD), in which basilar artery atheroma occludes penetrating arteries at their origin, is a common etiology of posterior circulation stroke (PCS). It is currently unknown whether white matter hyperintensity(WMH), a marker of small vessel disease(SVD), is associated with BABAD. METHODS: The present study analyzed data from patients with PCS who were enrolled in the Taipei Veterans General Hospital Stroke Registry between January 1, 2010 and February 28, 2014...
July 17, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28714527/multimodality-imaging-of-intermediate-lesions-data-from-ffr-oct-nirs-ivus
#17
Dariusz Biały, Magdalena Wawrzyńska, Jacek Arkowski, Marcin Rogała, Klaudia Proniewska, Wojciech Wańha, Wojciech Wojakowski, Tomasz Roleder
BACKGROUND: Fractional flow reserve (FFR) assesses a functional impact of the atheroma on the myocardial ischemia, but it does not take into account the morphology of the lesion. Previous optical coherence tomography (OCT), intravascular ultrasound (IVUS) and near infrared spectroscopy (NIRS) studies presented their potential to detect vulnerable plaque, which is not possible by FFR assessment. With the following study, the intermediate lesions were assessed by FFR, OCT and combined NIRS-IVUS imaging to identify plaque vulnerability...
July 17, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28712194/blocked-coronary-artery-due-to-coronary-spasm-treated-with-stent-insertion-a-sub-optimal-result
#18
Habib Rehman Khan, Sajid Aslam
Myocardial infarction (MI) is an extremely common cause of chest pain. MI can be acute with ST elevation (STEMI) or non-STEMI (NSTEMI). Coronary artery spasm can be severe enough to cause occlusion of the coronary arteries particularly with an exaggerated response in regions of coronary atheroma and plaque ulceration. It is not uncommon for coronary spasm to be mistaken with acute thrombotic occlusion of the coronary artery. We describe a case of a 42-year old man with known cardiac risk factors presents with chest pain for few hours to a tertiary centre hospital...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28699188/culprit-plaque-characteristics-in-younger-versus-older-patients-with-acute-coronary-syndromes-an-optical-coherence-tomography-study-from-the-formidable-registry
#19
Umberto Barbero, Paolo Scacciatella, Mario Iannaccone, Fabrizio D'Ascenzo, Giampaolo Niccoli, Francesco Colombo, Fabrizio Ugo, Salvatore Colangelo, Massimo Mancone, Calcagno Simone, Gennaro Sardella, Nicolas Amabile, Pascal Motreff, Konstantinos Toutouzas, Roberto Garbo, Corrado Tamburino, Antonio Montefusco, Pierluigi Omedè, Claudio Moretti, Maurizio D'amico, Geraud Souteyrand, Fiorenzo Gaita, Christian Templin
OBJECTIVES: Culprit plaque characteristics in young patients who experience an Acute Coronary Syndrome (ACS) evaluated by OCT (Optical Coherence Tomography) have to be defined. The OCT-FORMIDABLE is a multicentre retrospective registry enrolling consecutive patients with ACS who performed OCT in 9 European centres. METHODS: Patients were divided in two groups according to age at presentation: juvenile-ACS (age ≤ 50 years) and not juvenile-ACS (age > 50 years)...
July 12, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28697641/erectile-dysfunction-in-young-myocardial-infarction-survivors-evaluation-follow-up
#20
Gabriela Dostálová, Zuzana Hlubocká, Kristýna Bayerová, Jan Bělohlávek, Aleš Linhart, Debora Karetová
Erectile dysfunction significantly affects quality of life in young men. Authors have evaluated erectile function in men with coronary artery disease (CAD) and the relationship between the degree of erectile dysfunction (ED) and the age of their first acute myocardial infarction (AMI). The incidence of erectile dysfunction in three groups of patients of AMI survivors was investigated: AMI survivors younger than 45 years, AMI survivors older than 65 years, and normal male population aged between 30 and 60 years...
June 1, 2017: American Journal of Men's Health
keyword
keyword
100522
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"