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Theory of therapeutic action

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https://www.readbyqxmd.com/read/27859217/feeling-one-s-way-in-the-world-making-a-life
#1
Margaret M Browning
This paper argues for the psychoanalytic relevance of the works of James Gibson and Susanne Langer in explicating the early development of the human child and makes use of this combined formulation of development to think about psychoanalytic theory and practice. From the insights of James Gibson's ecological psychology we can appreciate the embodiment and embeddedness of the child's growing mind within both her physical and social environments. Making use of Susanne Langer's concept of feeling to redefine ecological psychology's perceptual counterpart to action allows us to understand the child's seamless transition into active participation in her culture, as she learns to project her animalian capacity to feel into intersubjectively defined forms of behavior and experience with others...
November 17, 2016: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/27858966/changes-in-interleukin-6-levels-during-electroconvulsive-therapy-may-reflect-the-therapeutic-response-in-major-depression
#2
K Järventausta, A Sorri, O Kampman, M Björkqvist, K Tuohimaa, M Hämäläinen, E Moilanen, E Leinonen, J Peltola, K Lehtimäki
OBJECTIVE: Interleukin-6 (IL-6) has been reported to be elevated in major depressive disorder (MDD) but decreased by antidepressive medication. IL-6 levels are markedly elevated both after epileptic seizures and single electroconvulsive therapy (ECT) session, but long-term changes in IL-6 levels after ECT have not been studied. The correlation between immediate and long-term changes in proinflammatory cytokines and outcome after ECT was investigated. METHOD: Thirty patients suffering from MDD participated in the study...
November 14, 2016: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/27833896/isolation-and-characterization-of-quinine-from-polygonatum-verticillatum-a-new-marker-approach-to-identify-substitution-and-adulteration
#3
Jaswinder Kaur Virk, Sanjiv Kumar, Ranjit Singh, Avinash C Tripathi, Shailendra K Saraf, Vikas Gupta, Parveen Bansal
Polygonatum verticillatum (Mahameda) is an important ingredient of Ashtawarga and Ayurvedic formulations. Nowadays, it comes under the category of endangered plants due to large scale and indiscriminate collection of wild material. To overcome the scarcity, substitutes of Mahameda are also commonly used in market. These additives are different from the authentic plant by Ayurvedic and pharmacological theory of drug action, thereby resulting in substitution/adulteration. Substitution is a critical issue in isolation and quantification of the therapeutically active ingredients that can be used as markers in the identification of substitution/adulteration...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27811467/genus-epidemicus-are-notions-of-entanglement-relevant-to-the-homeopathic-understanding-of-epidemic-disease
#4
Lionel R Milgrom
BACKGROUND: Patient-practitioner-remedy (PPR) entanglement postulates non-local triadic interaction between patient (Px), practitioner (Pr) and potentised medicine (Rx), resulting in the patient's journey to cure; the in-depth homeopathic interview is considered a major contributing factor in this process. Also, by modelling entelechy, a quantised gyroscopic analogue of the Vital Force (Vf) has been developed. OBJECTIVE: To discover whether entanglement notions explain the mode of action of homeopathy during the treatment of epidemic diseases, when the individualising in-depth homeopathic interview is neither possible nor necessary...
2016: Forschende Komplementärmedizin, Research in Complementary Medicine
https://www.readbyqxmd.com/read/27761807/identification-of-potential-therapeutics-to-conquer-drug-resistance-in-salmonella-typhimurium-drug-repurposing-strategy
#5
Balasundaram Preethi, Veerappapillai Shanthi, Karuppasamy Ramanathan
BACKGROUND: Salmonella typhimurium is the main cause of gastrointestinal illness in humans, and treatment options are decreasing because drug-resistant strains have emerged. OBJECTIVE: The objective of this study was to use computational drug repurposing to identify a novel candidate with an effective mechanism of action to circumvent the drug resistance. METHODS: We used the Mantra 2.0 database to initially screen drug candidates that share similar gene expression profiles to those of quinolones...
October 19, 2016: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/27687013/becoming-therapeutic-agents-a-grounded-theory-of-mothers-process-when-implementing-cognitive-behavioural-therapy-at-home-with-an-anxious-child
#6
Rana Pishva
: The premise of parent-centred programmes for parents of anxious children is to educate and train caregivers in the sustainable implementation of cognitive behaviour therapy (CBT) in the home. The existing operationalization of parent involvement, however, does not address the systemic, parent or child factors that could influence this process. The qualitative approach of grounded theory was employed to examine patterns of action and interaction involved in the complex process of carrying out CBT with one's child in one's home...
September 29, 2016: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/27648633/a-combination-of-complexation-and-self-nanoemulsifying-drug-delivery-system-for-enhancing-oral-bioavailability-and-anticancer-efficacy-of-curcumin
#7
Mahendra Shukla, Swati Jaiswal, Abhisheak Sharma, Pradeep Kumar Srivastava, Abhishek Arya, Anil Kumar Dwivedi, Jawahar Lal
OBJECTIVE: Curcumin, the golden spice from Indian saffron, has shown chemoprotective action against many types of cancer including breast cancer. However, poor oral bioavailability is the major hurdle in its clinical application. In the recent years, self-nanoemulsifying drug delivery system (SNEDDS) has emerged as a promising tool to improve the oral absorption and enhancing the bioavailability of poorly water-soluble drugs. In this context, complexation with lipid carriers like phospholipid has also shown the tremendous potential to improve the solubility and therapeutic efficacy of certain drugs with poor oral bioavailability...
October 6, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27603804/criticism-in-the-self-brain-relationships-and-social-structure-implications-for-psychodynamic-psychiatry
#8
Golan Shahar
An integrative-psychodynamic theory of criticism in self and relationships is presented (Shahar, 2015). My theoretical starting point is the tension between Authenticity (A; our inherited potential, tantamount to Winnicott's True Self) and Self-Knowledge (SK; what we [think] we know about ourselves). Self-criticism, a formidable dimension of vulnerability to a wide array of psychopathologies, is construed as a distorted form of self-knowledge, reducing internal confusion at the expense of widening the gap between A and SK...
December 0: Psychodynamic Psychiatry
https://www.readbyqxmd.com/read/27547627/multiwalled-carbon-nanotube-hybrids-as-mri-contrast-agents
#9
REVIEW
Nikodem Kuźnik, Mateusz Michał Tomczyk
Magnetic resonance imaging (MRI) is one of the most commonly used tomography techniques in medical diagnosis due to the non-invasive character, the high spatial resolution and the possibility of soft tissue imaging. Contrast agents, such as gadolinium complexes and superparamagnetic iron oxides, are administered to spotlight certain organs and their pathologies. Many new models have been proposed that reduce side effects and required doses of these already clinically approved contrast agents. These new candidates often possess additional functionalities, e...
2016: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/27510505/the-neurobiology-of-depression-an-integrated-overview-from-biological-theories-to-clinical-evidence
#10
F Ferrari, R F Villa
Depressive disorders are heterogeneous diseases, and the complexity of symptoms has led to the formulation of several aethiopathological hypotheses. This heterogeneity may account for the following open issues about antidepressant therapy: (i) antidepressants show a time lag between pharmacological effects, within hours from acute drug administration, and therapeutic effects, within two-four weeks of subchronic treatment; (ii) this latency interval is critical for the patient because of the possible further mood worsening that may result in suicide attempts for the seemingly ineffective therapy and for the apparent adverse effects; (iii) and only 60-70 % of treated patients successfully respond to therapy...
August 10, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27467393/does-facial-amimia-impact-the-recognition-of-facial-emotions-an-emg-study-in-parkinson-s-disease
#11
Soizic Argaud, Sylvain Delplanque, Jean-François Houvenaghel, Manon Auffret, Joan Duprez, Marc Vérin, Didier Grandjean, Paul Sauleau
According to embodied simulation theory, understanding other people's emotions is fostered by facial mimicry. However, studies assessing the effect of facial mimicry on the recognition of emotion are still controversial. In Parkinson's disease (PD), one of the most distinctive clinical features is facial amimia, a reduction in facial expressiveness, but patients also show emotional disturbances. The present study used the pathological model of PD to examine the role of facial mimicry on emotion recognition by investigating EMG responses in PD patients during a facial emotion recognition task (anger, joy, neutral)...
2016: PloS One
https://www.readbyqxmd.com/read/27460598/conflicting-perspectives-on-neurobehavioral-theories-of-the-depressive-disorders-and-drug-actions
#12
Martin M Katz
OBJECTIVE: A prominent theory of depression focusses on neural plasticity and stress as central issues in seeking to develop a pattern of identifiable biological markers for the depressive disorders. Relative neglect, however, of clinical factors in that theory limits the uncovering of markers and opens to question their methodological approach. A conflicting theory, the 'opposed neurobehavioral states', based on dimensional analysis of monoamine neurotransmitter systems and behavioural factors is presented...
December 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27453459/the-role-of-macrophages-in-anti-inflammatory-activity-of-antidepressant-drugs
#13
Katarzyna Nazimek, Spencer Strobel, Paweł Bryniarski, Michael Kozlowski, Iwona Filipczak-Bryniarska, Krzysztof Bryniarski
Depression is a common disease influencing patients' quality of life, whose etiology involves complex interactions of environmental, genetic and immunological factors. The latter factors include proinflammatory activation of monocytes and macrophages and increased serum levels of proinflammatory cytokines, altogether formulated as the "macrophage theory of depression". Our current review summarizes the impact of the most commonly used antidepressant drugs on the immune response with special emphasis on the role of macrophages in the clinically observed effects...
July 14, 2016: Immunobiology
https://www.readbyqxmd.com/read/27303305/mechanisms-of-electrical-activation-and-conduction-in-the-gastrointestinal-system-lessons-from-cardiac-electrophysiology
#14
REVIEW
Gary Tse, Eric Tsz Him Lai, Jie Ming Yeo, Vivian Tse, Sunny Hei Wong
The gastrointestinal (GI) tract is an electrically excitable organ system containing multiple cell types, which coordinate electrical activity propagating through this tract. Disruption in its normal electrophysiology is observed in a number of GI motility disorders. However, this is not well characterized and the field of GI electrophysiology is much less developed compared to the cardiac field. The aim of this article is to use the established knowledge of cardiac electrophysiology to shed light on the mechanisms of electrical activation and propagation along the GI tract, and how abnormalities in these processes lead to motility disorders and suggest better treatment options based on this improved understanding...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27285677/physiology-and-endocrinology-symposium-insulin-action-and-lipotoxicity-in-the-development-of-polycystic-ovary-syndrome-a-review
#15
J Faubert, M-C Battista, J-P Baillargeon
Polycystic ovary syndrome (PCOS) is a common condition affecting women of reproductive age. This disorder is characterized by hyperandrogenism and anovulation and is frequently associated with comorbidities such as infertility, metabolic syndrome, type 2 diabetes, and cardiovascular risk factors. Although the causes of PCOS are unknown, this review focuses on the most accepted theory involving insulin action but will also elaborate on a novel concept: the role of lipotoxicity in the development of androgen overproduction, in addition to its known role in insulin resistance...
May 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27227433/virtual-experiments-enable-exploring-and-challenging-explanatory-mechanisms-of-immune-mediated-p450-down-regulation
#16
Brenden K Petersen, Glen E P Ropella, C Anthony Hunt
Hepatic cytochrome P450 levels are down-regulated during inflammatory disease states, which can cause changes in downstream drug metabolism and hepatotoxicity. Long-term, we seek sufficient new insight into P450-regulating mechanisms to correctly anticipate how an individual's P450 expressions will respond when health and/or therapeutic interventions change. To date, improving explanatory mechanistic insight relies on knowledge gleaned from in vitro, in vivo, and clinical experiments augmented by case reports...
2016: PloS One
https://www.readbyqxmd.com/read/27148085/computerized-exercises-to-promote-transfer-of-cognitive-skills-to-everyday-life
#17
REVIEW
Pascal Vianin
In recent years, computerized and non-computerized cognitive remediation programs have been designed for both individual and group settings. We believe, however, that a common misconception lies in considering the efficiency of a cognitive remediation therapy as resulting from the sole use of a computer. This omits that metacognitive skills need also to be trained throughout the remediation phase. RECOS is a theory-based therapeutic approach designed to promote the transfer of cognitive skills to functional improvements...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/26958653/vaccination-developing-and-implementing-a-competency-based-curriculum-at-the-medical-faculty-of-lmu-munich
#18
B Vogel, S Reuter, M Taverna, M R Fischer, J Schelling
BACKGROUND: In Germany medical students should gain proficiency and specific skills in the vaccination field. Especially important is the efficient communication of scientific results about vaccinations to the community, in order to give professional counseling with a complete overview about therapeutic options. AIM OF THE PROJECT: The aim of this project is to set up a vaccination-related curriculum in the Medical Faculty at the Ludwig-Maximilians-University in Munich. The structure of the curriculum is based on the National catalogue for competency-based learning objectives in the field of vaccination (Nationaler Kompetenzbasierter Lernzielekatalog Medizin NKLM)...
2016: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/26956384/role-of-trophic-factors-gdnf-igf-1-and-vegf-in-major-depressive-disorder-a-comprehensive-review-of-human-studies
#19
REVIEW
Ajaykumar N Sharma, Bruno Fernando Borges da Costa e Silva, Jair C Soares, André F Carvalho, Joao Quevedo
RATIONALE: The neurotrophin hypothesis of major depressive disorder (MDD) postulates that this illness results from aberrant neurogenesis in brain regions that regulates emotion and memory. Notwithstanding this theory has primarily implicated BDNF in the neurobiology of MDD. Recent evidence suggests that other trophic factors namely GDNF, VEGF and IGF-1 may also be involved. PURPOSE: The present review aimed to critically summarize evidence regarding changes in GDNF, IGF-1 and VEGF in individuals with MDD compared to healthy controls...
June 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/26905326/poly-adp-ribose-polymerase-in-cervical-cancer-pathogenesis-mechanism-and-potential-role-for-parp-inhibitors
#20
Ioannis C Kotsopoulos, Ali Kucukmetin, Asima Mukhopadhyay, John Lunec, Nicola J Curtin
Treatment options for disease recurrence of women treated for locally advanced and advanced cervical cancer are very limited-largely palliative chemotherapy. The low efficacy of the currently available drugs raises the need for new targeted agents. Poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors (PARPi) have emerged as a promising class of chemotherapeutic agents in cancers associated with defects in DNA repair. Their therapeutic potential in cervical cancer is currently being evaluated in 3 ongoing clinical trials...
May 2016: International Journal of Gynecological Cancer
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