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Theory of therapeutic action

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https://www.readbyqxmd.com/read/29492098/development-of-models-for-classification-of-action-between-heat-clearing-herbs-and-blood-activating-stasis-resolving-herbs-based-on-theory-of-traditional-chinese-medicine
#1
Zhao Chen, Yanfeng Cao, Shuaibing He, Yanjiang Qiao
Background: Action (" gongxiao " in Chinese) of traditional Chinese medicine (TCM) is the high recapitulation for therapeutic and health-preserving effects under the guidance of TCM theory. TCM-defined herbal properties (" yaoxing " in Chinese) had been used in this research. TCM herbal property (TCM-HP) is the high generalization and summary for actions, both of which come from long-term effective clinical practice in two thousands of years in China. However, the specific relationship between TCM-HP and action of TCM is complex and unclear from a scientific perspective...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29489952/-integration-of-primary-care-in-the-healthcare-network-analysis-of-the-components-in-the-external-evaluation-of-the-pmaq-ab
#2
Lenir Aparecida Chaves, Alzira de Oliveira Jorge, Mariangela Leal Cherchiglia, Ilka Afonso Reis, Marcos Antônio da Cunha Santos, Alaneir de Fátima Santos, Antônio Thomaz Gonzaga da Matta Machado, Eli Iola Gurgel Andrade
This cross-sectional study examined the integration of primary care in the healthcare network of the Brazilian Unified National Health System (SUS), using the Gradual Response Model of Item Response Theory. Based on data from 17,202 teams that participated in the National Program for Access and Quality Improvement in Primary Care (PMAQ-AB, 2012), we measured gradients of integration to identify the teams' profile by level of integration. The results show that the items pertaining to matrix support measures (medical consultations, case discussions, shared clinical action, joint elaboration of therapeutic projects, permanent educational activities, work process discussions, interventions in the territory, and visits with primary care professionals) improved the performance of primary care teams...
February 19, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29457330/modeling-suicide-in-bipolar-disorders
#3
REVIEW
Gin S Malhi, Tim Outhred, Pritha Das, Grace Morris, Amber Hamilton, Zola Mannie
INTRODUCTION: Suicide is a multicausal human behavior, with devastating and immensely distressing consequences. Its prevalence is estimated to be 20-30 times greater in patients with bipolar disorders than in the general population. The burden of suicide and its high prevalence in bipolar disorders make it imperative that our current understanding be improved to facilitate prediction of suicide and its prevention. In this review, we provide a new perspective on the process of suicide in bipolar disorder, in the form of a novel integrated model that is derived from extant knowledge and recent evidence...
February 19, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29419330/organ-based-drug-delivery
#4
Mohammad Alsaggar, Dexi Liu
The phenomenal advances in pharmaceutical sciences over the last few decades have led to the development of new therapeutics like peptides, proteins, RNAs, DNAs and highly potent small molecules. Fruitful applications of these therapeutics have been challenged by several anatomical and physiological barriers that limit adequate drug disposition at the site of action and by off-target drug distribution to undesired tissues, which together result in the reduced effectiveness and increased side effects of therapeutic agents...
February 8, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29354983/-interpretation-of-acupuncture-theory-from-acupuncture-application
#5
Jingsheng Zhao
The relationship between acupuncture theory and clinical practice is getting problematic with the development of acupuncture clinical practice. In the paper, in view of the theoretic study itself, the reasons and the approaches to the recognition are explored. The characteristics of acupuncture therapeutic methods include the site for application and the technique method in generally. Their theoretical construction is relatively limited in the system category of acupuncture. The sites of acupuncture application are various, including vessels, the muscle regions of meridians, the intersection of skin and muscle, corresponding points and others...
October 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29332579/alzheimer-s-disease-a-systemic-review-of-substantial-therapeutic-targets-and-the-leading-multi-functional-molecules
#6
REVIEW
Tarana Umar, Nasimul Hoda
Alzheimer's Disease (AD) is a fatal neurodegenerative disorder, having a complex aetiology with numerous possible drug targets. There are targets that have been known for years while more new targets and theories have also emerged. Beta amyloid and cholinesterases are the most significant biological targets for finding curative treatment of AD. The major class of drugs used for AD till now has been the Cholinesterase (ChE) inhibitors. Other prevailing models of molecular pathogenesis in AD include Neurofibrillary Tangles (NFTs) and amyloid deposition, tryptophan degradation pathway, kinase and phosphatase activity imbalance and neuroinflammation...
2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29308955/a-qualitative-study-of-clinical-reasoning-in-physiotherapy-with-preterm-infants-and-their-parents-action-and-interaction
#7
Ragnhild B Håkstad, Aud Obstfelder, Gunn Kristin Øberg
BACKGROUND: Physiotherapists (PTs) in primary health care provide services to preterm infants and their parents after hospital discharge. The service should be collaborative and individualized to meet the family's needs. In this study, we analyze pediatric PTs' collaborative work in the clinical setting and investigate the PTs' emerging clinical reasoning (CR) in interaction with the infant and parent(s). METHODS: The study is based on observations of 20 physical therapy sessions and 20 interviews with PTs...
January 8, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29300334/understanding-the-progression-of-bone-metastases-to-identify-novel-therapeutic-targets
#8
REVIEW
Annie Schmid-Alliana, Heidy Schmid-Antomarchi, Rasha Al-Sahlanee, Patricia Lagadec, Jean-Claude Scimeca, Elise Verron
Bone is one of the most preferential target site for cancer metastases, particularly for prostate, breast, kidney, lung and thyroid primary tumours. Indeed, numerous chemical signals and growth factors produced by the bone microenvironment constitute factors promoting cancer cell invasion and aggression. After reviewing the different theories proposed to provide mechanism for metastatic progression, we report on the gene expression profile of bone-seeking cancer cells. We also discuss the cross-talk between the bone microenvironment and invading cells, which impacts on the tumour actions on surrounding bone tissue...
January 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29261228/overview-of-monoamine-transporters
#9
Shaili Aggarwal, Ole V Mortensen
The dopamine (DAT), serotonin (SERT), and norepinephrine (NET) transporters, which are collectively referred to as monoamine transporters (MATs), play significant roles in regulating the neuronal response to these neurotransmitters. MATs terminate the action of these neurotransmitters by translocating them from the synaptic space into the presynaptic neurons. These three transmitters are responsible for controlling a number of physiological, emotional, and behavioral functions, with their transporters being the site of action of drugs employed for the treatment of a variety of conditions, including depression, anxiety, ADHD, schizophrenia, and psychostimulant abuse...
December 20, 2017: Current Protocols in Pharmacology
https://www.readbyqxmd.com/read/29231878/greek-medicine-practice-at-ancient-rome-the-physician-molecularist-asclepiades
#10
Luigi Santacroce, Lucrezia Bottalico, Ioannis Alexandros Charitos
Background: In the pre-Hellenistic period, the concept of medicine was not well-defined. Usually, a disease was considered as a divine punishment and its treatment was devolved to the priests who asked for healing from the divinities. The only job that could be compared to medical practice was a kind of itinerant medicine, derived from the Egyptian therapeutic tradition based only on practical experience and performed by people that knew a number of remedies, mostly vegetable, but without any theoretical bases about the possible mechanisms of action...
December 12, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29227740/women-s-strategies-for-coping-with-the-impacts-of-domestic-violence-in-kyrgyzstan-a-grounded-theory-study
#11
Saltanat Childress, Deborah Gioia, Jacquelyn C Campbell
This paper provides an account of the adverse impacts of domestic violence on women in Kyrgyzstan and develops a grounded theory of coping among survivors of abuse. The results indicate that women adopt a range of strategies to prevent, avert, and minimize anticipated violence. Two key aspects of coping appeared in the narratives: 1) maintaining the status quo and 2) developing agency to resist the abuse. The results suggest that Government and nongovernmental organizations must take additional action to draw women to formal violence prevention services...
March 2018: Social Work in Health Care
https://www.readbyqxmd.com/read/29194534/why-not-try-harder-computational-approach-to-motivation-deficits-in-neuro-psychiatric-diseases
#12
Mathias Pessiglione, Fabien Vinckier, Sébastien Bouret, Jean Daunizeau, Raphaël Le Bouc
Motivation deficits, such as apathy, are pervasive in both neurological and psychiatric diseases. Even when they are not the core symptom, they reduce quality of life, compromise functional outcome and increase the burden for caregivers. They are currently assessed with clinical scales that do not give any mechanistic insight susceptible to guide therapeutic intervention. Here, we present another approach that consists of phenotyping the behaviour of patients in motivation tests, using computational models...
November 29, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29174034/panax-notoginseng-saponins-reduce-high-risk-factors-for-thrombosis-through-peroxisome-proliferator-activated-receptor-%C3%AE-pathway
#13
Qin Shen, Jun Li, Caixin Zhang, Pengbo Wang, Anaz Mohammed, Songshi Ni, Zhiyuan Tang
The classic Virchow theory suggests that blood stasis, hypercoagulability and endothelial dysfunction are three major factors that cause venous thrombosis (VT). It is a complicated biological process involved multi-factors. Platelet plays a central role and participates in multiple links of this process. Panax notoginseng saponins (PNS), the principal constituents derived from panax notoginseng, has been widely described for its anti-platelet activity. However, its potential mechanism against platelet aggregation has not been clarified...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28955286/talking-cure-models-a-framework-of-analysis
#14
REVIEW
Christopher Marx, Cord Benecke, Antje Gumz
Psychotherapy is commonly described as a "talking cure," a treatment method that operates through linguistic action and interaction. The operative specifics of therapeutic language use, however, are insufficiently understood, mainly due to a multitude of disparate approaches that advance different notions of what "talking" means and what "cure" implies in the respective context. Accordingly, a clarification of the basic theoretical structure of "talking cure models," i.e., models that describe therapeutic processes with a focus on language use, is a desideratum of language-oriented psychotherapy research...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28946612/meditative-movement-energetic-and-physical-analyses-of-three-qigong-exercises-unification-of-eastern-and-western-mechanistic-exercise-theory
#15
Penelope Klein, George Picard, Joseph Baumgarden, Roger Schneider
Abstract : Qigong is the meditative movement and therapeutic exercise of Eastern medicine. A growing body of evidence is validating its health benefits leading to mechanistic questions of how it works. The purpose of this article is to explore mechanisms of action related to Qigong, with the intent of unifying Eastern and Western exercise theory and to present a model for Qigong exercise analysis. Three exercises from a standardized Qigong form: 'Plucking the Stars', 'Lotus Leaves Rustle in the Wind', and 'Pacing Forwards and Backwards' were selected for meditative, energetic, and physical analyses...
September 23, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28936108/changing-internal-representations-of-self-and-other-philosophical-tools-for-the-attachment-informed-psychotherapy-with-perpetrators-and-victims-of-violence
#16
Alexandra Pârvan
Attachment research shows that the formation of unconscious, insecure representations of the self, the other, and the self-other relations is linked to perpetration and receipt of violence. Attachment-focused therapy aims to change these internal schemata to more secure, adaptive representations by therapeutic work addressed to senses, emotions, and behavior. The paper proposes a new approach to altering the self and other representations in offenders and victims: it involves intellectual reflection on self, will, action and responsibility informed by Augustine's views, facilitated by actual relational experience, and translated into a distinct self-soothing strategy...
September 2017: Philosophy, Psychiatry, & Psychology: PPP
https://www.readbyqxmd.com/read/28930561/immune-ligands-for-cytotoxic-t-lymphocytes-ctls-in-cancer-stem-cells-cscs
#17
Ioannis A Voutsadakis
   The immune system has come to the forefront of cancer therapeutics in recent years with the success of immune blockade inhibitors in a variety of cancers whose list is increasing with a quick pace. Despite the efficacy of these drugs across a significant part of the cancer spectrum, responses are still seen only in a minority of patients, that implies that most patients are refractory or promptly develop resistance to these agents. Mechanisms of this resistance are important to decipher as this knowledge may lead to the introduction of additional therapies or manipulations to modulate resistance...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28840608/a-practice-model-for-rural-district-nursing-success-in-end-of-life-advocacy-care
#18
Frances M Reed, Les Fitzgerald, Melanie R Bish
AIM: The development of a practice model for rural district nursing successful end-of-life advocacy care. BACKGROUND: Resources to help people live well in the end stages of life in rural areas can be limited and difficult to access. District nurse advocacy may promote end-of-life choice for people living at home in rural Australia. The lack of evidence available internationally to inform practice in this context was addressed by exploratory study. METHOD: A pragmatic mixed method study approved by the University Faculty Ethics Committee and conducted from March 2014 to August 2015 was used to explore the successful end-of-life advocacy of 98 rural Australian district nurses...
August 24, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28822202/-q-marker-of-chinese-medicine-and-metabolic-regularity-of-co-network-compatibility-and-rainbow-potential
#19
Yan-Tao Yang, Sen Li, Jin-Ling Liu, Jin Zhou, Yi-Qun Zhou, Nai-Hong Chen, Fu-Yuan He
The effect of Chinese medicine (CM) compound prescription is the combined action results of single herbs based on the basic theory of Chinese medicine, and its function embodies the characteristics of multi components, multi targets and comprehensive effects. It is difficult to study the therapeutic material, establish quality standards or determine Q-marker, so we can't strictly monitor the quality of the whole process of CM. The identification of Q-marker has a profound influence on the whole process of the pharmaceutical engineering of CM...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28822200/-analysis-on-dosage-form-theory-and-current-application-situation-of-traditional-chinese-medicine-pill
#20
Zhen Zhang, Tian-Hui Gao, Chao-Mei Fu, Jin-Ming Zhang, Jin-Feng Shi, Yao He, Heng Yin, Mao-Yuan Jiang, Jie Li, Fei Gao
Traditional Chinese medicine(TCM) pill, the most representative and successive dosage form, is called as one of the four classical TCM dosage forms. "Pills could keep the lasting and lenitive therapeutic efficacy for a long period" is the most classical dosage form theory, showing a guidance significance in making recipe, preparations and clinic application. In this article, we would elucidate the inheritance and development significance of TCM pills in three key points, including dosage form theory, pharmaceutical preparation technology and clinic usage based on the pharmaceutics connotation of this theory...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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