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Lisinopril dose

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https://www.readbyqxmd.com/read/27829805/effect-of-amlodipine-lisinopril-and-allopurinol-on-acetaminophen-induced-hepatotoxicity-in-rats
#1
Nesreen E M Mohammed, Basim A S Messiha, Ali A Abo-Saif
BACKGROUND: Exposure to chemotherapeutic agents such as acetaminophen may lead to serious liver injury. Calcium deregulation, angiotensin II production and xanthine oxidase activity are suggested to play mechanistic roles in such injury. OBJECTIVE: This study evaluates the possible protective effects of the calcium channel blocker amlodipine, the angiotensin converting enzyme inhibitor lisinopril, and the xanthine oxidase inhibitor allopurinol against experimental acetaminophen-induced hepatotoxicity, aiming to understand its underlying hepatotoxic mechanisms...
November 2016: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/27727195/evaluation-of-certain-pharmaceutical-quality-attributes-of-lisinopril-split-tablets
#2
Khairi M S Fahelelbom, Moawia M M Al-Tabakha, Nermin A M Eissa, Jeevani Javadi
Tablet splitting is an accepted practice for the administration of drugs for a variety of reasons, including dose adjustment, ease of swallowing and cost savings. The purpose of this study was to evaluate the physical properties of lisinopril tablets as a result of splitting the tablets either by hand or with a splitting device. The impact of the splitting technique of lisinopril (Zestril(®) tablets, 20 mg) on certain physical parameters such as weight variation, friability, disintegration, dissolution and drug content were studied...
October 11, 2016: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/27682899/combined-hydration-and-antibiotics-with-lisinopril-to-mitigate-acute-and-delayed-high-dose-radiation-injuries-to-multiple-organs
#3
Brian L Fish, Feng Gao, Jayashree Narayanan, Carmen Bergom, Elizabeth R Jacobs, Eric P Cohen, John E Moulder, Christie M Orschell, Meetha Medhora
The NIAID Radiation and Nuclear Countermeasures Program is developing medical agents to mitigate the acute and delayed effects of radiation that may occur from a radionuclear attack or accident. To date, most such medical countermeasures have been developed for single organ injuries. Angiotensin converting enzyme (ACE) inhibitors have been used to mitigate radiation-induced lung, skin, brain, and renal injuries in rats. ACE inhibitors have also been reported to decrease normal tissue complication in radiation oncology patients...
November 2016: Health Physics
https://www.readbyqxmd.com/read/27682140/therapeutic-efficacy-and-safety-of-ace-inhibitors-in-the-hypertensive-paediatric-population-a-review
#4
REVIEW
Evelien Snauwaert, Johan Vande Walle, Pauline De Bruyne
PURPOSE: Since 1997, strong incentives have been introduced worldwide to improve access to safe and effective medicines addressing the therapeutic needs of children. ACE inhibitors, the most prescribed antihypertensive drugs in the paediatric population, are one of the prototype drugs targeted by the legislation initiatives. Our purpose in assembling this review is to evaluate and describe the current evidence for the efficacy and safety profile of ACE inhibitors in the paediatric population...
September 28, 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27615269/lisinopril-has-a-cardio-protective-effect-on-experimental-acute-autoimmune-myocarditis-in-rats
#5
Muhammad Atteya, Raeesa A Mohamed, Aly M Ahmed, Nayira A Abdel-Baky, Musaad A Alfayez, Hatim D Almalke, Ahmed F El Fouhil
PURPOSE: The present study investigated the effect of lisinopril on experimental autoimmune myocarditis (EAM) in rats, a histologically similar model to human acute myocarditis. ANIMALS AND METHODS: Twenty four, six week-old male Wistar rats were randomly allocated into 4 groups of 6 rats each. Group I received no treatment. Group II received lisinopril at a dose of 15 mg/kg/day suspended in 1 ml of 2% gum acacia daily, from day 1 to day 21. To induce myocarditis, animals of groups III and IV were injected by 1 mg of porcine cardiac myosin on days 1 and 8...
September 7, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27508790/-op-6d-01-estradiol-increases-endothelial-angiotensin-1-7-production-through-estrogen-receptor-alpha
#6
C Hermenegildo, A Mompeon, D Perez-Cremades, X Vidal-Gomez, M M Gironacci, S Novella
OBJECTIVE: Over-activity of the classic renin angiotensin system (RAS) has been implicated in the pathophysiology of cardiovascular diseases primarily through the vasoconstrictor and inflammatory properties of Angiotensin (Ang)II. The non-classic RAS may counteract some AngII effects through its diversion to synthesize the vasodilator Ang-(1-7). Wealth of evidence shows that estrogens provide vascular protective effects by modulating the RAS. We previously reported estradiol (E2) effects on endothelial gene expression profile, demonstrating an increase in ACE1...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508656/-op-1a-09-the-relationship-between-the-aggression-level-of-patients-with-arterial-hypertension-and-the-antihypertensive-drug-effectiveness
#7
G Andreeva, V Gorbunov, V Beloliperskaya, S Kukushkin, E Zvolinskaya, O Lerman
OBJECTIVE: The aim of study was to define relationships between psychological traits of patients with arterial hypertension (AH) and the antihypertensive drug effectiveness.(Figure is included in full-text article.) DESIGN AND METHOD: : We analyzed ambulatory blood pressure monitoring (ABPM) data of 275 patients with AH without serious concomitant diseases We used data base of several studies with the same design: 1) the washout period duration - 1-2 weeks; 2) initial ABPM session (SpaceLabs 90207) before treatment; 3) treatment with standard therapeutic doses (amlodipin, diltiazem, metoprolol, betaxolol, enalapril, moxonidin, lisinopril) with the addition of diuretic if needed; 4) psychological status assessment was performed by the psychological questionnaire "Minnesota Multiphase Personality Inventory"(MMPI) before and at the end of the treatment...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27435368/effects-of-equol-on-deoxycorticosterone-acetate-salt-induced-hypertension-and-associated-vascular-dementia-in-rats
#8
Te-Hua Liu, Tsung-Yu Tsai
Oxidative stress is the major cause of neuronal cell degeneration observed in neurodegenerative diseases including vascular dementia (VaD), and hypertension has been found to increase the probability of VaD. Here, we investigated the effects of equol in deoxycorticosterone acetate (DOCA)-salt-induced hypertensive rats (DHRs) and the associated VaD. The systolic blood pressure of rats treated with low- (10 mg per kg body weight) and high-dose (20 mg per kg body weight) equol for 4 weeks was lower than that of the control group by 12...
August 10, 2016: Food & Function
https://www.readbyqxmd.com/read/27411694/pregnancy-experience-nonclinical-studies-and-pregnancy-outcomes-in-the-daclizumab-clinical-study-program
#9
Ralf Gold, Dusan Stefoski, Krzysztof Selmaj, Eva Havrdova, Christopher Hurst, Joan Holman, Belen Tornesi, Surekha Akella, Peter McCroskery
INTRODUCTION: Multiple sclerosis (MS) is more common in women and can occur during childbearing years; thus, information on outcomes following exposure to MS therapy during pregnancy is important. No formal studies of daclizumab have been conducted in pregnant women. Here, we report available nonclinical and clinical data on pregnancy outcomes from the daclizumab clinical study program. METHODS: Reproductive and developmental toxicity studies were conducted in cynomolgus monkeys...
December 2016: Neurology and Therapy
https://www.readbyqxmd.com/read/27146273/methods-for-using-clinical-laboratory-test-results-as-baseline-confounders-in-multi-site-observational-database-studies-when-missing-data-are-expected
#10
Marsha A Raebel, Susan Shetterly, Christine Y Lu, James Flory, Joshua J Gagne, Frank E Harrell, Kevin Haynes, Lisa J Herrinton, Elisabetta Patorno, Jennifer Popovic, Mano Selvan, Azadeh Shoaibi, Xingmei Wang, Jason Roy
PURPOSE: Our purpose was to quantify missing baseline laboratory results, assess predictors of missingness, and examine performance of missing data methods. METHODS: Using the Mini-Sentinel Distributed Database from three sites, we selected three exposure-outcome scenarios with laboratory results as baseline confounders. We compared hazard ratios (HRs) or risk differences (RDs) and 95% confidence intervals (CIs) from models that omitted laboratory results, included only available results (complete cases), and included results after applying missing data methods (multiple imputation [MI] regression, MI predictive mean matching [PMM] indicator)...
July 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27010897/the-renin-angiotensin-system-and-its-vasoactive-metabolite-angiotensin-1-7-in-the-mechanism-of-the-healing-of-preexisting-gastric-ulcers-the-involvement-of-mas-receptors-nitric-oxide-prostaglandins-and-proinflammatory-cytokines
#11
M W Pawlik, S Kwiecien, A Ptak-Belowska, R Pajdo, R Olszanecki, M Suski, J Madej, A Targosz, S J Konturek, R Korbut, T Brzozowski
The inhibition of angiotensin-converting enzyme (ACE) or the blockade of angiotensin (Ang) AT-1 receptors affords protection against acute gastric mucosal injury, but whether the major metabolite of renin-angiotensin system (RAS), Ang-(1-7), accelerates the healing process of preexisting gastric ulcers remains unknown. Previous studies documented that Ang-(1-7) acting via its own Mas receptor exerts vascular responses opposing those of Ang II. We studied the effects of the Ang-(1-7)/Mas receptor axis on the healing rate of acetic-acid-induced gastric ulcers with or without the blockade of Mas receptors by A 779 and compared it with the effects of activation and blockade of the AT-1 receptor by the treatment with Ang II and losartan, respectively, the inhibition of ACE by lisinopril, the NO/cNOS inhibition by L-NAME and inhibition of prostaglandin/COX system by indomethacin in the presence of Ang-(1-7)...
February 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/26981294/acute-kidney-injury-associated-with-linagliptin
#12
Deepak K Nandikanti, Elvira O Gosmanova, Aidar R Gosmanov
Linagliptin is a dipeptidyl peptidase-IV (DPP-IV) inhibitor that is approved for the treatment of type 2 diabetes mellitus. About 5% of linagliptin is eliminated by the kidneys and no dose adjustment is recommended in kidney impairment. We report a first case of linagliptin-associated acute kidney injury (AKI) in a patient with preexisting chronic kidney disease (CKD). We hypothesize that AKI was due to renal hypoperfusion from linagliptin-induced natriuresis and intravascular volume contraction in the setting of concomitant lisinopril use, which is known to impair autoregulation and potentiate hypotension-induced AKI...
2016: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/26943616/garlic-capsule-and-selenium-vitamins-ace-combination-therapy-modulate-key-antioxidant-proteins-and-cellular-adenosine-triphosphate-in-lisinopril-induced-lung-damage-in-rats
#13
Jacob K Akintunde, Olakunle Enock Bolarin, Daniel G Akintunde
BACKGROUND: Garlic capsule (GAR) and/or selenium- vitamin A, C, E (S-VACE) might be useful in the treatment of lung diseases. The present study evaluated the toxicity of lisinopril (LIS) in the lungs of male rats and the reversal effect of GAR and/or selenium-vitamins A, C, and E (S-VACE). METHODS: Group I served as the control, whereas animals in groups II, III, IV, and V received 28 mg of LIS/kg body weight by gavage. Group III was co-treated with GAR at a therapeutic dosage of 250 mg/kg body weight per day...
March 1, 2016: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/26882895/impact-of-clinically-tested-nep-ace-inhibitors-on-tumor-uptake-of-111-in-dota-mg11-first-estimates-for-clinical-translation
#14
Aikaterini Kaloudi, Berthold A Nock, Emmanouil Lymperis, Roelf Valkema, Eric P Krenning, Marion de Jong, Theodosia Maina
BACKGROUND: We have recently shown that treatment of mice with the neutral endopeptidase (NEP) inhibitor phosphoramidon (PA) improves the bioavailability and tumor uptake of biodegradable radiopeptides. For the truncated gastrin radiotracer [(111)In-DOTA]MG11 ([(DOTA)DGlu(10)]gastrin(10-17)), this method led to impressively high tumor-to-kidney ratios. Translation of this concept in the clinic requires the use of certified NEP inhibitors, such as thiorphan (TO) and its orally administered prodrug racecadotril (Race)...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/26743587/estimated-cardiovascular-relative-risk-reduction-from-fixed-dose-combination-pill-polypill-treatment-in-a-wide-range-of-patients-with-a-moderate-risk-of-cardiovascular-disease
#15
Melvin Lafeber, Ruth Webster, Frank Lj Visseren, Michiel L Bots, Diederick E Grobbee, W Spiering, Anthony Rodgers
AIMS: Recent data indicate that fixed-dose combination (FDC) pills, polypills, can produce sizeable risk factor reductions. There are very few published data on the consistency of the effects of a polypill in different patient populations. It is unclear for example whether the effects of the polypill are mainly driven by the individuals with high individual risk factor levels. The aim of the present study is to examine whether baseline risk factor levels modify the effect of polypill treatment on low-density lipoprotein (LDL)-cholesterol, blood pressure (BP), calculated cardiovascular relative risk reduction and adverse events...
August 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/26709600/evaluation-of-the-effect-of-angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptors-blockers-on-aspirin-antiplatelet-effect
#16
Sayer I Al-Azzam, Karem H Alzoubi, Omar F Khabour, Maram Quttina, Raya Zayadeen
OBJECTIVE: Cardiovascular disease (CVD) is one of the major burdens on societies and healthcare systems. Antiplatelet aspirin is used to prevent the occurrence or reoccurrence of cardiovascular events. However, studies have shown that a good portion of patients still suffer from cardiovascular events in spite of using aspirin (also called aspirin nonresponders). On the other hand, angiotensin-converting enzyme inhibitors (ACEIs) as well as angiotensin-receptor blockers (ARBs) are widely used in patients with different spectrums of cardiovascular diseases...
February 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/26708684/-ramipril-plus-amlodipine-and-lisinopril-plus-amlodipine-fixed-dose-combinations-and-patient-s-adherence
#17
Gábor Simonyi, Tamás Ferenci
INTRODUCTION: Patient's adherence has a great significance to reach target blood pressure values. The risk of cardiovascular adverse events decreases when patients are on target blood pressure. AIM: The aim of the authors was to investigate the one-year persistence of the ramipril/amlodipine and lisinopril/amlodipine fixed dose combination in hypertensive patients. METHOD: National Health Insurance Found prescriptions database of Hungary on pharmacy-claims between October 1, 2012 and September 30, 2013 was analyzed...
January 3, 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/26625516/-the-antihypertensive-effect-of-the-fixed-combination-of-lisinopril-and-amlodipine-in-patients-with-coronary-heart-disease-after-coronary-artery-bypass-grafting
#18
RANDOMIZED CONTROLLED TRIAL
A V Panov, M Z Alugishvili, I T Abesadze, N L Lohovinina, K V Korzenewskaya, I V Titenkov, E V Kuleshova, D V Dyplyakov, S M Hohlunov, A V Kryukov, R A Libis, E N Isayeva, I R Basyrova, D V Safonova
Literature data and results of our own register have indicate that hypertension is one of the most common risk factor in patients with ischemic heart disease (IHD) who have undergone coronary artery bypass grafting (CABG). But despite proven benefits of control of hypertension after CABG adherence of patients to corresponding recommendations remains low. Fixed combinations of antihypertensive drugs are associated with better compliance. In 30 IHD patients after CABG we studied effects of fixed lisinoprillamlodipine combination...
2015: Kardiologiia
https://www.readbyqxmd.com/read/26597252/liraglutide-in-type-2-diabetes-mellitus-clinical-pharmacokinetics-and-pharmacodynamics
#19
Lisbeth V Jacobsen, Anne Flint, Anette K Olsen, Steen H Ingwersen
Liraglutide is an acylated glucagon-like peptide-1 analogue with 97 % amino acid homology with native glucagon-like peptide-1 and greatly protracted action. It is widely used for the treatment of type 2 diabetes mellitus, and administered by subcutaneous injection once daily. The pharmacokinetic properties of liraglutide enable 24-h exposure coverage, a requirement for 24-h glycaemic control with once-daily dosing. The mechanism of protraction relates to slowed release from the injection site, and a reduced elimination rate owing to metabolic stabilisation and reduced renal filtration...
June 2016: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/26589819/should-antihypertensive-treatment-recommendations-differ-in-patients-with-and-without-coronary-heart-disease-from-the-antihypertensive-and-lipid-lowering-treatment-to-prevent-heart-attack-trial-allhat
#20
RANDOMIZED CONTROLLED TRIAL
Michael H Alderman, Barry R Davis, Linda B Piller, Charles E Ford, M Sarah Baraniuk, Sara L Pressel, Mahshid A Assadi, Paula T Einhorn, L Julian Haywood, Ekambaram Ilamathi, Suzanne Oparil, Tamrat M Retta
Thiazide-type diuretics have been recommended for initial treatment of hypertension in most patients, but should this recommendation differ for patients with and without coronary heart disease (CHD)? The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized, double-blind hypertension treatment trial in 42,418 participants with high risk of combined cardiovascular disease (CVD) (25% with preexisting CHD). This post hoc analysis compares long-term major clinical outcomes in those assigned amlodipine (n = 9048) or lisinopril (n = 9,054) with those assigned chlorthalidone (n = 15,255), stratified by CHD status...
January 1, 2016: American Journal of Cardiology
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