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non-motor symptoms in Parkinson's disease

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https://www.readbyqxmd.com/read/27905364/-transcranial-magnetic-stimulation-in-parkinson-s-disease
#1
G N Tayupova, A R Saitgareeva, A R Baitimerov, O S Levin
This review presents the results of studies investigating the effects of transcranial magnetic stimulation (TKMS) on motor and non-motor symptoms of Parkinson's disease (PD). It has been found that TKMS reduces the severity of both motor and non-motor disorders without causing serious side-effects. Magnetic field therapy can be combined with pharmacological and non-drug therapies, including the use of dopaminergic therapy, antidepressants and anti-dementia drugs, as well as stereotactic operations. It is necessary to continue the study of the influence of TKMS on the severity of PD symptoms using different electromagnetic characteristics...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27905362/-characteristics-of-parkinson-s-disease-course-in-the-heterozygous-carriage-of-mutations-in-the-glucocerebrosidase-a-gene
#2
O A Gan'kina, E E Vasenina, O S Levin, E Yu Fedotova, S N Illarioshkin
Parkinson's disease (PD) is a common neurodegenerative disease. Literature sources indicate the association of PD and mutations in the glucocerebrosidase A (GBA) gene. According to our study, the frequency of the two most common mutations in the GBA gene, N370S and L444P, is 1.85%. Mutation carriers have slower progression of motor symptoms, but are more likely to develop drug-induced motor fluctuations and dyskinesia. In carriers of GBA mutations, the severity of cognitive impairment corresponds to age-matched patients without mutations...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27905361/-heterogeneity-of-excessive-daytime-sleepiness-in-parkinson-s-disease
#3
O V Babkina, M G Poluektov, O S Levin
For the recent years, a special attention is given to the non-motor symptoms of Parkinson's disease, including sleep/wake disorders representing one of the leading symptoms. Daytime sleepiness occurs in 30-55% of patients depending on duration and stage of the disease, leading to severe maladjustment. This symptom seems to be multifactorial by nature and identification of it's causes could have a great importance for the therapy. The main factors of the development of daytime sleepiness in Parkinson's disease and key points of the pathogenesis of «primary» daytime sleepiness are discussed...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27899296/targeting-the-norepinephrinergic-system-in-parkinson-s-disease-and-related-disorders-the-locus-coeruleus-story
#4
Yannick Vermeiren, Peter P De Deyn
Parkinson's disease (PD), dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are related, progressive and debilitating neurodegenerative disorders with hallmark features that include a variety of motor and non-motor symptoms (behavioral, autonomic and cognitive dysfunction). For almost half a century, the motor aspects have been attributed to Lewy pathology (LP) predominantly in the substantia nigra (SN), causing a major loss of dopaminergic neurons. However, the relative success of dopaminergic replacement therapies for alleviation of solely the parkinsonian features has prompted researchers to further explore other monoaminergic strategies which may tackle all PD-related aspects...
November 26, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27889469/changes-in-neural-circuitry-associated-with-depression-at-pre-clinical-pre-motor-and-early-motor-phases-of-parkinson-s-disease
#5
REVIEW
Janina Borgonovo, Camilo Allende-Castro, Almudena Laliena, Néstor Guerrero, Hernán Silva, Miguel L Concha
Although Parkinson's Disease (PD) is mostly considered a motor disorder, it can present at early stages as a non-motor pathology. Among the non-motor clinical manifestations, depression shows a high prevalence and can be one of the first clinical signs to appear, even a decade before the onset of motor symptoms. Here, we review the evidence of early dysfunction in neural circuitry associated with depression in the context of PD, focusing on pre-clinical, pre-motor and early motor phases of the disease. In the pre-clinical phase, structural and functional changes in the substantia nigra, basal ganglia and limbic structures are already observed...
November 21, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27873569/establishing-a-standard-of-care-for-deep-brain-stimulation-centers-in-canada
#6
Michel Panisset, Marina Picillo, Nicolas Jodoin, Yu-Yan Poon, Alejandro Valencia-Mizrachi, Alfonso Fasano, Renato Munhoz, Christopher R Honey
During the "DBS Canada Day" symposium held in Toronto July 4-5, 2014, the scientific committee invited experts to share their knowledge regarding deep brain stimulation (DBS) management of movement disorders in three domains: (1) the programming algorithms, (2) the necessary team to run a neurosurgery program, and (3) the appropriate scales to better define in a more comprehensive fashion the effect of the brain surgery. Each presentation was followed by an open discussion, and this article reports on the conclusions of this meeting on these three questions...
November 22, 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27871937/elevated-levels-of-alpha-synuclein-blunt-cellular-signal-transduction-downstream-of-gq-protein-coupled-receptors
#7
Mattia Volta, Alexandros A Lavdas, Julia Obergasteiger, Christa Überbacher, Anne Picard, Peter P Pramstaller, Andrew A Hicks, Corrado Corti
Alpha-synuclein is central to Parkinson's disease pathogenesis and pathology, however its precise functions are still unclear. It has been shown to bind both PLCβ1 and MAPKs, but how this property influences the downstream signaling of Gq protein-coupled receptors has not been elucidated. Here we show that recombinant expression of alpha-synuclein in human neuroblastoma cells enhances cellular levels of PLCβ1 but blunts its signaling pathway, preventing the agonist-dependent rise of cytoplasmic Ca(2+). In addition, overexpressing alpha-synuclein abolishes the activation of ERK1/2 upon agonist stimulation, indicating an upstream action in the signal transduction pathway...
November 18, 2016: Cellular Signalling
https://www.readbyqxmd.com/read/27866991/parkinson-s-disease-like-motor-and-non-motor-symptoms-in-rotenone-treated-zebrafish
#8
Yali Wang, Wenwen Liu, Jing Yang, Fen Wang, Sima Yizhen, Zhao-Min Zhong, Han Wang, Li-Fang Hu, Chun-Feng Liu
The pesticide rotenone is widely used to produce Parkinson's disease (PD)-like symptoms in rodents, but few studies have examined whether rotenone-treated zebrafish can serve as an animal model of PD. Here, we report that 4 weeks of rotenone treatment induced motor and non-motor PD-like symptoms in adult zebrafish. Compared with control fish, rotenone-treated fish spent less time swimming at a fast speed, indicating a deficit in motor function. In the light-dark box test, rotenone-treated fish exhibited longer latencies to enter the dark compartment and spent more time in the light compartment, reflecting anxiety- and depression-like behavior...
November 17, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27863901/a-systematic-review-of-the-literature-on-disorders-of-sleep-and-wakefulness-in-parkinson-s-disease-from-2005-to-2015
#9
REVIEW
Lama M Chahine, Amy W Amara, Aleksandar Videnovic
Sleep disorders are among the most common non-motor manifestations in Parkinson's disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the general population, there are several considerations specific to this patient population regarding diagnosis, management, and implications. The available research on these disorders is expanding rapidly, but many questions remain unanswered. We thus conducted a systematic review of the literature published from 2005 to 2015 on the following disorders of sleep and wakefulness in PD: REM sleep behavior disorder, insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders...
August 31, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/27859638/alterations-of-the-circadian-system-in-parkinson-s-disease-patients
#10
Karim Fifel
Alterations of circadian rhythms are among the most debilitating non-motor symptoms in Parkinson's Disease (PD). Although a growing awareness towards these symptoms has occurred during the last decade, their underlying neuropathophysiology remains poorly understood and consequently no effective therapeutic strategies are available to alleviate these problems. Recent studies have investigated multiple circadian rhythms at different stages of PD. The advances made have allowed an accurate evaluation of the affected underlying pathways and mechanisms...
November 15, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27858720/challenges-of-improving-patient-centred-care-in-parkinson-s-disease
#11
Soania Mathur, Leah Mursaleen, Jon Stamford, Steve DeWitte, Israel Robledo, Tom Isaacs
BACKGROUND: Parkinson's disease is a neurodegenerative condition with a complex pattern of motor and non-motor symptoms. Of several clinical scales used to measure patient experience few are delivered by patients themselves. OBJECTIVE: The present study reports the results of an online survey to establish (a) factors that most influence QoL (quality of life) for people with Parkinson's and (b) areas where self-monitoring may help. METHODS: A 27 question online survey (using Survey Monkey) was developed by The Cure Parkinson's Trust, comprising four main sections (demographics, monitoring, symptoms and communication)...
November 14, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27855167/assessment-of-olfactory-function-in-mapt-associated-neurodegenerative-disease-reveals-odor-identification-irreproducibility-as-a-non-disease-specific-general-characteristic-of-olfactory-dysfunction
#12
Katerina Markopoulou, Bruce A Chase, Piotr Robowski, Audrey Strongosky, Ewa Narożańska, Emilia J Sitek, Mariusz Berdynski, Maria Barcikowska, Matt C Baker, Rosa Rademakers, Jarosław Sławek, Christine Klein, Katja Hückelheim, Meike Kasten, Zbigniew K Wszolek
Olfactory dysfunction is associated with normal aging, multiple neurodegenerative disorders, including Parkinson's disease, Lewy body disease and Alzheimer's disease, and other diseases such as diabetes, sleep apnea and the autoimmune disease myasthenia gravis. The wide spectrum of neurodegenerative disorders associated with olfactory dysfunction suggests different, potentially overlapping, underlying pathophysiologies. Studying olfactory dysfunction in presymptomatic carriers of mutations known to cause familial parkinsonism provides unique opportunities to understand the role of genetic factors, delineate the salient characteristics of the onset of olfactory dysfunction, and understand when it starts relative to motor and cognitive symptoms...
2016: PloS One
https://www.readbyqxmd.com/read/27852849/robust-cns-pathology-in-transgenic-mice-following-peripheral-injection-of-%C3%AE-synuclein-fibrils
#13
Jacob I Ayers, Mieu M Brooks, Nicola J Rutherford, Jasie K Howard, Zachary A Sorrentino, Cara J Riffe, Benoit I Giasson
: Misfolded α-synuclein (αS) is hypothesized to spread throughout the CNS by neuronal connectivity leading to widespread pathology. Increasing evidence indicates that it also has the potential to invade the CNS via peripheral nerves in a prion-like manner. Based on the effectiveness following peripheral routes of prion administration, we extend our previous studies of CNS neuroinvasion in M83 αS transgenic mice following hindlimb muscle (IM) injection of αS fibrils by comparing various peripheral sites of inoculations with different αS protein preparations...
November 16, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27833551/c-abl-inhibitors-enable-insights-into-the-pathophysiology-and-neuroprotection-in-parkinson-s-disease
#14
REVIEW
Dan Lindholm, Dan D Pham, Annunziata Cascone, Ove Eriksson, Krister Wennerberg, Mart Saarma
Parkinson's disease (PD) is a progressive neurodegenerative disorder causing movement disabilities and several non-motor symptoms in afflicted patients. Recent studies in animal models of PD and analyses of brain specimen from PD patients revealed an increase in the level and activity of the non-receptor tyrosine kinase Abelson (c-Abl) in dopaminergic neurons with phosphorylation of protein substrates, such as α-synuclein and the E3 ubiquitin ligase, Parkin. Most significantly inhibition of c-Abl kinase activity by small molecular compounds used in the clinic to treat human leukemia have shown promising neuroprotective effects in cell and animal models of PD...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27826233/the-parkinsonian-subthalamic-network-measures-of-power-linear-and-non-linear-synchronization-and-their-relationship-to-l-dopa-treatment-and-off-state-motor-severity
#15
Timothy West, Simon Farmer, Luc Berthouze, Ashwani Jha, Martijn Beudel, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Peter Brown, Vladimir Litvak
In this paper we investigated the dopaminergic modulation of neuronal interactions occurring in the subthalamic nucleus (STN) during Parkinson's disease (PD). We utilized linear measures of local and long range synchrony such as power and coherence, as well as Detrended Fluctuation Analysis for Phase Synchrony (DFA-PS)- a recently developed non-linear method that computes the extent of long tailed autocorrelations present in the phase interactions between two coupled signals. Through analysis of local field potentials (LFPs) taken from the STN we seek to determine changes in the neurodynamics that may underpin the pathophysiology of PD in a group of 12 patients who had undergone surgery for deep brain stimulation...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27823833/prevalence-and-risk-factors-for-visual-hallucinations-in-chinese-patients-with-parkinson-s-disease
#16
Jun Zhu, Bo Shen, Liyu Lu, Wenya Lan, Yang Pan, Lili Zhang, Jingde Dong, Min Wang, Li Zhang
BACKGROUND AND PURPOSE: Parkinson's disease (PD) patients frequently present visual hallucinations (VHs)·The determinants of VHs in Chinese PD patients remain largely unknown. The aim of this study was to illuminate the prevalence and clinical correlates of VHs in the Chinese population with PD. METHODS: A total of 371 consecutive, idiopathic PD patients were recruited into the study. Patients were categorized as hallucinators and nonhallucinators according to Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS)...
October 27, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27819413/the-kmds-nation-study-korean-movement-disorders-society-multicenter-assessment-of-non-motor-symptoms-and-quality-of-life-in-parkinson-s-disease-nation-study-group
#17
Do Young Kwon, Seong Beom Koh, Jae Hyeok Lee, Hee Kyung Park, Han Joon Kim, Hae Won Shin, Jinyoung Youn, Kun Woo Park, Sun Ah Choi, Sang Jin Kim, Seong Min Choi, Ji Yun Park, Beom S Jeon, Ji Young Kim, Sun Ju Chung, Chong Sik Lee, Jeong Ho Park, Tae Beom Ahn, Won Chan Kim, Hyun Sook Kim, Sang Myung Cheon, Hee Tae Kim, Jee Young Lee, Ji Sun Kim, Eun Joo Kim, Jong Min Kim, Kwang Soo Lee, Joong Seok Kim, Min Jeong Kim, Jong Sam Baik, Ki Jong Park, Hee Jin Kim, Mee Young Park, Ji Hoon Kang, Sook Kun Song, Yong Duk Kim, Ji Young Yun, Ho Won Lee, Hyung Geun Oh, Jinwhan Cho, In Uk Song, Young H Sohn, Phil Hyu Lee, Jae Woo Kim
BACKGROUND AND PURPOSE: Nonmotor symptoms (NMS) in Parkinson's disease (PD) have multisystem origins with heterogeneous manifestations that develop throughout the course of PD. NMS are increasingly recognized as having a significant impact on the health-related quality of life (HrQoL). We aimed to determine the NMS presentation according to PD status, and the associations of NMS with other clinical variables and the HrQoL of Korean PD patients. METHODS: We surveyed patients in 37 movement-disorders clinics throughout Korea...
October 2016: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/27818912/evaluating-and-managing-sleep-disorders-in-the-parkinson-s-disease-clinic
#18
S Gulyani, R Salas, Z Mari, S Choi, A Mahajan, C Gamaldo
Parkinson's disease is a multi-systems neurodegenerative disorder that is characterized by a combination of motor and non-motor symptoms. Non-motor symptoms of Parkinson's disease comprise a variety of cognitive, neuropsychiatric, autonomic, sensory, and sleep complaints. Although sleep disruption represents one of the most common non-motor symptom complaints among Parkinson's disease patients, recommendations regarding effective evaluation and management strategies for this specific population remain limited...
August 2016: Basal Ganglia
https://www.readbyqxmd.com/read/27814772/-manganese-induced-neurotoxicity-a-review-of-its-behavioral-consequences-and-neuroprotective-strategies
#19
REVIEW
Tanara V Peres, Maria Rosa C Schettinger, Pan Chen, Fabiano Carvalho, Daiana S Avila, Aaron B Bowman, Michael Aschner
Manganese (Mn) is an essential heavy metal. However, Mn's nutritional aspects are paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we covered recent advances in identifying mechanisms of Mn uptake and its molecular actions in the brain as well as promising neuroprotective strategies. The authors focused on reporting findings regarding Mn transport mechanisms, Mn effects on cholinergic system, behavioral alterations induced by Mn exposure and studies of neuroprotective strategies against Mn intoxication...
November 4, 2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27812756/a-prospective-evaluation-of-taste-in-parkinson-s-disease
#20
M J Ricatti, S Ottaviani, F Boschi, A Fasano, M Tinazzi, M P Cecchini
It is well known that Parkinson's disease is characterized by a variety of non-motor symptoms. A gustatory deficit is hypothesized to be one of them although few and only cross-sectional studies are available. The aim of our pilot study was to prospectively investigate the taste function in Parkinson's disease patients after some years from the first evaluation (mean follow-up 4.35 ± 0.49 years; time range 3.5-5.6 years). A group of 26 patients was re-examined (16 males and 10 females; mean age 70.9 ± 8...
November 3, 2016: Journal of Neural Transmission
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