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https://www.readbyqxmd.com/read/27754163/sy-11-3-hypertension-in-women-more-dangerous-than-in-men
#1
Suzanne Oparil
Heart disease, stroke, and kidney failure are leading causes of death worldwide, and hypertension is a significant risk factor for each. Hypertension is less common in women, compared to men, in those younger than 45 years of age. This trend is reversed in those 65 years and older. In the US between 2011-2014, the prevalence of hypertension in women and men by age group was 6% vs 8% (18-39 years), 30% vs 35% (40-59 years), and 67% vs 63% (60 years and over). Awareness, treatment, and control rates differ between genders with women being more aware of their diagnosis (85% vs 80%), more likely to take their medications (81% vs 71%) and more frequently having controlled hypertension (55% vs 49%)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753973/os-11-06-the-effect-of-vagus-nerve-stimulation-on-arterial-hypertension-using-active-implantable-device
#2
Sekib Sokolovic, Samir Mehmedagic
OBJECTIVE: The goal of this paper was to present the effects of the vagus nerve stimulation (VNS) on a blood pressure (BP) and heart rate (HR) in arterial hypertension patient. DESIGN AND METHOD: The pilot study (SPM-005) was designed to evaluate the eficiancy and safety profile of the neurostimulation of the cholinergic anti-inflammatory pathways using the active implantable device for the vagus nerve stimulation in rheumatoid arthritis patient. We investigated the VNS on the BP and HR in 68 years old female patient with a long-standing arterial hypertension and the lisinopril and hydrochlorothiazide in a therapy...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643370/os-11-06-the-effect-of-vagus-nerve-stimulation-on-arterial-hypertension-using-active-implantable-device
#3
Sekib Sokolovic, Samir Mehmedagic
OBJECTIVE: The goal of this paper was to present the effects of the vagus nerve stimulation (VNS) on a blood pressure (BP) and heart rate (HR) in arterial hypertension patient. DESIGN AND METHOD: The pilot study (SPM-005) was designed to evaluate the eficiancy and safety profile of the neurostimulation of the cholinergic anti-inflammatory pathways using the active implantable device for the vagus nerve stimulation in rheumatoid arthritis patient. We investigated the VNS on the BP and HR in 68 years old female patient with a long-standing arterial hypertension and the lisinopril and hydrochlorothiazide in a therapy...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643118/sy-11-3-hypertension-in-women-more-dangerous-than-in-men
#4
Suzanne Oparil
Heart disease, stroke, and kidney failure are leading causes of death worldwide, and hypertension is a significant risk factor for each. Hypertension is less common in women, compared to men, in those younger than 45 years of age. This trend is reversed in those 65 years and older. In the US between 2011-2014, the prevalence of hypertension in women and men by age group was 6% vs 8% (18-39 years), 30% vs 35% (40-59 years), and 67% vs 63% (60 years and over). Awareness, treatment, and control rates differ between genders with women being more aware of their diagnosis (85% vs 80%), more likely to take their medications (81% vs 71%) and more frequently having controlled hypertension (55% vs 49%)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27465904/primacy-of-cardiac-chymase-over-angiotensin-converting-enzyme-as-an-angiotensin-1-12-metabolizing-enzyme
#5
Sarfaraz Ahmad, Jasmina Varagic, Jessica L VonCannon, Leanne Groban, James F Collawn, Louis J Dell'Italia, Carlos M Ferrario
We showed previously that rat angiotensin-(1-12) [Ang-(1-12)] is metabolized by chymase and angiotensin converting enzyme (ACE) to generate Angiotensin II (Ang II). Here, we investigated the affinity of cardiac chymase and ACE enzymes for Ang-(1-12) and Angiotensin I (Ang I) substrates. Native plasma membranes (PMs) isolated from heart and lung tissues of adult spontaneously hypertensive rats (SHR) were incubated with radiolabeled (125)I-Ang-(1-12) or (125)I-Ang I, in the absence or presence of a chymase or ACE inhibitor (chymostatin and lisinopril, respectively)...
September 16, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27411694/pregnancy-experience-nonclinical-studies-and-pregnancy-outcomes-in-the-daclizumab-clinical-study-program
#6
Ralf Gold, Dusan Stefoski, Krzysztof Selmaj, Eva Havrdova, Christopher Hurst, Joan Holman, Belen Tornesi, Surekha Akella, Peter McCroskery
INTRODUCTION: Multiple sclerosis (MS) is more common in women and can occur during childbearing years; thus, information on outcomes following exposure to MS therapy during pregnancy is important. No formal studies of daclizumab have been conducted in pregnant women. Here, we report available nonclinical and clinical data on pregnancy outcomes from the daclizumab clinical study program. METHODS: Reproductive and developmental toxicity studies were conducted in cynomolgus monkeys...
December 2016: Neurology and Therapy
https://www.readbyqxmd.com/read/26895877/-nihilism-of-chronic-heart-failure-therapy-in-children-and-why-effective-therapy-is-withheld
#7
REVIEW
Dietmar Schranz, Norbert F Voelkel
UNLABELLED: Major advances in chronic heart failure (cHF) therapy have been achieved and documented in adult patients, while research regarding the mechanisms and therapy of cHF in children has lagged behind. Based on receptor physiological studies and pharmacological knowledge, treatment with specific ß1-adrenergic receptor blocker (ARB), tissue angiotensin-converting enzyme inhibitor (ACE-I), and mineralocorticoid antagonists have to be recommended in children despite lack of sufficient data derived from prospective randomized studies...
April 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/26871774/comparison-of-the-efficacy-and-safety-of-different-ace-inhibitors-in-patients-with-chronic-heart-failure-a-prisma-compliant-network-meta-analysis
#8
COMPARATIVE STUDY
WeiPing Sun, HaiBin Zhang, JinCheng Guo, XueKun Zhang, LiXin Zhang, ChunLei Li, Ling Zhang
Heart failure is a public health problem and a great economic burden for patients and healthcare systems. Suppression of the renin-angiotensin system (RAS) by angiotensin-converting enzyme (ACE)-inhibitors remains the mainstay of treatment for heart failure. However, the abundance of ACE inhibitors makes it difficult for doctors to choose.We performed this network meta-analysis of ACEIs in patients with heart failure in order to address this area of uncertainty.We searched PubMed, Embase, CENTRAL, and Medline...
February 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26761971/-cardio-nephroprotection-the-most-important-goal-of-antihypertensive-therapy-in-patients-with-type-2-diabetes
#9
M E Statsenko, M V Derevyanchenko
AIM: to study the opportunities for cardio and nephroprotection by 6-month combined antihypertensive therapy with lisinopril and amlodipine in hypertensive patients with diabetes mellitus (DM) type 2. MATERIALS AND METHODS: 30 patients with arterial hypertension (AH) stage II-III, chronic kidney disease (CKD) stages 2-3 and type 2 DM were included in to research. We evaluated the results of the physical examination, blood pressure monitoring (ABPM), structural and functional state of the heart and kidneys...
2015: Kardiologiia
https://www.readbyqxmd.com/read/26589819/should-antihypertensive-treatment-recommendations-differ-in-patients-with-and-without-coronary-heart-disease-from-the-antihypertensive-and-lipid-lowering-treatment-to-prevent-heart-attack-trial-allhat
#10
RANDOMIZED CONTROLLED TRIAL
Michael H Alderman, Barry R Davis, Linda B Piller, Charles E Ford, M Sarah Baraniuk, Sara L Pressel, Mahshid A Assadi, Paula T Einhorn, L Julian Haywood, Ekambaram Ilamathi, Suzanne Oparil, Tamrat M Retta
Thiazide-type diuretics have been recommended for initial treatment of hypertension in most patients, but should this recommendation differ for patients with and without coronary heart disease (CHD)? The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized, double-blind hypertension treatment trial in 42,418 participants with high risk of combined cardiovascular disease (CVD) (25% with preexisting CHD). This post hoc analysis compares long-term major clinical outcomes in those assigned amlodipine (n = 9048) or lisinopril (n = 9,054) with those assigned chlorthalidone (n = 15,255), stratified by CHD status...
January 1, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/25455006/stroke-outcomes-among-participants-randomized-to-chlorthalidone-amlodipine-or-lisinopril-in-allhat
#11
RANDOMIZED CONTROLLED TRIAL
José-Miguel Yamal, Suzanne Oparil, Barry R Davis, Michael H Alderman, David A Calhoun, William C Cushman, Herbert F Fendley, Stanley S Franklin, Gabriel B Habib, Sara L Pressel, Jeffrey L Probstfield, Sithiporn Sastrasinh
The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) was a randomized, double-blind, practice-based, active-control, comparative effectiveness trial in 33,357 high-risk hypertensive participants. ALLHAT compared cardiovascular disease outcomes in participants initially treated with an angiotensin-converting enzyme inhibitor (lisinopril), a calcium channel blocker (amlodipine), or a thiazide-type diuretic (chlorthalidone). We report stroke outcomes in 1517 participants in-trial and 1596 additional participants during post-trial passive surveillance, for a total follow-up of 8-13 years...
November 2014: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/25271183/lipid-emulsion-use-precluding-renal-replacement-therapy
#12
Betzaida Rodríguez, Andrew Wilhelm, Kenneth E Kokko
BACKGROUND: Intralipid emulsion (ILE) is a nutritional fatty acid supplementation that is emerging as a potential therapy for local anesthetic systemic toxicity and is also being considered as a therapy for other lipophilic medication intoxications. Isolated reports of pulmonary edema or severe lipemia exist as a complication of therapy. CASE REPORT: A 26-year-old hypertensive, male, kidney transplant recipient presented to an outside emergency department (ED) after an intentional overdose of his medications (ie, amlodipine, metoprolol, lisinopril)...
December 2014: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/25131919/cardiovascular-mortality-in-hypertensive-patients-newly-prescribed-perindopril-vs-lisinopril-a-5-year-cohort-study-of-15-622-chinese-subjects
#13
COMPARATIVE STUDY
Kelvin K F Tsoi, Martin C S Wong, Wilson W S Tam, Hoyee W Hirai, X Q Lao, Harry H X Wang, Mandy W M Kwan, Clement S K Cheung, Ellen L H Tong, N T Cheung, Bryan P Yan, Helen M L Meng, Sian M Griffiths
BACKGROUND: Perindopril and lisinopril are two common ACE inhibitors prescribed for management of hypertension. Few studies have evaluated their comparative effectiveness to reduce mortality. This study compared the all-cause and cardiovascular related mortality among patients newly prescribed ACE inhibitors. METHODS: All adult patients newly prescribed perindopril or lisinopril from 2001 to 2005 in all public clinics or hospitals in Hong Kong were retrospectively evaluated, and followed up until 2010...
October 20, 2014: International Journal of Cardiology
https://www.readbyqxmd.com/read/25002161/characteristics-and-long-term-follow-up-of-participants-with-peripheral-arterial-disease-during-allhat
#14
RANDOMIZED CONTROLLED TRIAL
Linda B Piller, Lara M Simpson, Sarah Baraniuk, Gabriel B Habib, Mahboob Rahman, Jan N Basile, Richard A Dart, Allan J Ellsworth, Herbert Fendley, Jeffrey L Probstfield, Paul K Whelton, Barry R Davis
BACKGROUND: Hypertension is a major risk factor for peripheral artery disease (PAD). Little is known about relative efficacy of antihypertensive treatments for preventing PAD. OBJECTIVES: To compare, by randomized treatment groups, hospitalized or revascularized PAD rates and subsequent morbidity and mortality among participants in the Antihypertensive and Lipid-Lower Treatment to Prevent Heart Attack Trial (ALLHAT). DESIGN: Randomized, double-blind, active-control trial in high-risk hypertensive participants...
November 2014: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/24800478/-optimization-of-pharmacotherapy-in-patients-with-essential-hypertension-with-neurohumoral-modulators-with-consideration-of-data-on-heart-rate-variability
#15
S M Kakhramanova, A B Bakhshaliev
Long-term treatment of patients with essential hypertension (EH) and autonomic dysfunction (sympathicotonia type) with lisinopril in combination with indapamide augmented activity of humoral systems and improved heart rate variability. Addition of a selective beta-blocker bisoprolol to lisinopril/indapamide combination promoted normalization of humoral activity. This gives reason to apply tiered RAAS blockade in order to ensure more effective control of activity of neurohumoral systems in patients with EH ant initial sympathicotonia...
2013: Kardiologiia
https://www.readbyqxmd.com/read/24735381/the-effect-of-angiotensin-converting-enzyme-inhibitors-on-the-rate-of-ascending-aorta-dilation-in-patients-with-bicuspid-aortic-valve
#16
Daniella Ohnemus, Matthew E Oster, Scott Gatlin, Maan Jokhadar, William T Mahle
BACKGROUND: Bicuspid aortic valve (BAV), the most common congenital heart defect, is associated with progressive aortic dilation and increased risk of dissection and rupture. The use of an angiotensin-converting enzyme (ACE) inhibitor has recently proven effective in slowing the rate of aortic dilation in other aortopathies, suggesting it may also be useful in managing BAV. We sought to determine whether ACE inhibitors effectively reduce the rate of aortic dilation in adolescents and young adults with BAV...
January 2015: Congenital Heart Disease
https://www.readbyqxmd.com/read/24717718/angiotensinergic-neurotransmission-in-the-paraventricular-nucleus-of-the-hypothalamus-modulates-the-pressor-response-to-acute-restraint-stress-in-rats
#17
C Busnardo, R F Tavares, F M A Correa
We tested the hypothesis that the angiotensinergic neurotransmission, specifically in the paraventricular nucleus of the hypothalamus (PVN), is involved in the cardiovascular modulation during acute restraint stress (RS) in rats. The intravenous pretreatment with the angiotensin AT1 receptor antagonist losartan (5mg/kg) inhibited the pressor response to RS, but did not affect the concomitant RS-evoked tachycardiac response. Because similar effects were observed after the PVN pretreatment with CoCl2, and considering the high density of angiotensin receptors reported in the PVN, we studied the effect of the pretreatment of the PVN with either losartan or the angiotensin-converting enzyme (ACE) inhibitor lisinopril on the RS-evoked cardiovascular response...
June 13, 2014: Neuroscience
https://www.readbyqxmd.com/read/24640663/-impact-of-combination-antihypertensive-therapy-on-heart-rate-variability-parameters-and-target-organ-status-in-patients-with-arterial-hypertension-and-type-2-diabetes-mellitus
#18
M E Statsenko, M V Derevianchenko, M N Titarenko, A V Mihaleva
AIM: To evaluate the impact of combination antihypertensive therapy with ekvator on heart rate variability (HRV) parameters and target organ status in patients with arterial hypertension (AH) and type 2 diabetes mellitus (T2DM). SUBJECTS AND METHODS: The investigation enrolled 30 patients aged 40-65 years with Stages II--III AH concurrent with T2DM. All the patients received combination antihypertensive therapy with amlodipine + lisinopril for 12 weeks. HRV parameters, baseline autonomic tone, and autonomic responsiveness were studied, by analyzing ECG reading of their hearts in the 5-minute segments...
2013: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/24398888/hypertension-in-hemodialysis-patients-treated-with-atenolol-or-lisinopril-a-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Rajiv Agarwal, Arjun D Sinha, Maria K Pappas, Terri N Abraham, Getachew G Tegegne
BACKGROUND: The purpose of this study was to determine among maintenance hemodialysis patients with echocardiographic left ventricular hypertrophy and hypertension whether in comparison with a β-blocker-based antihypertensive therapy, an angiotensin converting enzyme-inhibitor-based antihypertensive therapy causes a greater regression of left ventricular hypertrophy. METHODS: Subjects were randomly assigned to either open-label lisinopril (n = 100) or atenolol (n = 100) each administered three times per week after dialysis...
March 2014: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/23815535/effects-of-nebivolol-on-aortic-compliance-in-patients-with-diabetes-and-maximal-renin-angiotensin-system-blockade-the-effort-study
#20
RANDOMIZED CONTROLLED TRIAL
Alexandros Briasoulis, Raymond Oliva, Rigas Kalaitzidis, Colleen Flynn, Ivana Lazich, Carrie Schlaffer, George Bakris
The beneficial effects of nebivolol on arterial stiffness and endothelial dysfunction are well documented in untreated hypertensive patients and differ from nonvasodilatory β-blockers. This study tests the hypothesis that the addition of nebivolol in predominantly African American patients with type 2 diabetes already receiving maximally tolerated doses of renin-angiotensin system (RAS) blockers will further improve large artery compliance. Patients with type 2 diabetes and hypertension on maximal RAS blockade (n=70) were randomized to nebivolol or metoprolol succinate daily...
July 2013: Journal of Clinical Hypertension
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