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Structure Function Analysis in Glaucoma

Gai-Yun Li, Samer Abdo Al-Wesabi, Hong Zhang
The aim of this study was to determine whether differences exist in oxygen supply to the optic nerve head (ONH) from the retinal and choroidal vascular layers in patients with primary open angle glaucoma (POAG) using multispectral imaging (MSI).This ia an observational, cross-sectional study.Multispectral images were acquired from 38 eyes of 19 patients with POAG, and 42 healthy eyes from 21 matched volunteers with Annidis' RHA multispectral digital ophthalmoscopy. Superficial and deeper oxygen saturation of the optic disc was represented by the mean gray scale values on the retinal and choroidal oxy-deoxy maps, respectively...
December 2016: Medicine (Baltimore)
Mohamed S Sayed, Michael Margolis, Richard K Lee
PURPOSE OF REVIEW: Optical coherence tomography (OCT) has become an integral component of modern glaucoma practice. Utilizing color codes, OCT analysis has rendered glaucoma diagnosis and follow-up simpler and faster for the busy clinician. However, green labeling of OCT parameters suggesting normal values may confer a false sense of security, potentially leading to missed diagnoses of glaucoma and/or glaucoma progression. RECENT FINDINGS: Conditions in which OCT color coding may be falsely negative (i...
December 7, 2016: Current Opinion in Ophthalmology
Edward Bloch, Ekaterina Yonova-Doing, Eneh Jones-Odeh, Katie M Williams, Diana Kozareva, Christopher J Hammond
Importance: Measurement of ganglion cell complex (GCC) thickness may be more sensitive than current methods for glaucoma diagnosis and research. However, little is known about the factors influencing GCC thickness in the general population. Objectives: To investigate the heritability of and factors associated with GCC thickness in a healthy aging population. Design, Setting, and Participants: A cross-sectional twin study was conducted from August 27, 2014, to March 31, 2016, among 1657 participants of white British ancestry from the TwinsUK study cohort without ocular pathologic conditions...
January 1, 2017: JAMA Ophthalmology
Harsha L Rao, Sujatha V Kadambi, Srilakshmi Dasari, Hemanth B Reddy, Meena Palakurthy, Mohammed Riyazuddin, Narendra K Puttaiah, Zia S Pradhan, Dhanaraj A S Rao, Rohit Shetty
PURPOSE: To predict the intereye asymmetry in functional (mean deviation, MD on visual field, VF) and structural (retinal nerve fibre layer, RNFL and ganglion cell complex, GCC thickness on spectral domain optical coherence tomography, SDOCT) measurements in glaucoma using the automated pupillography parameters. METHODS: Fifty-nine subjects with a diagnosis of either glaucoma or glaucoma suspect underwent automated pupillography along with VF and SDOCT examinations...
November 22, 2016: Acta Ophthalmologica
M Zeitoun
PURPOSE: To try to establish a "point by point" relationship between the local thickness of the retinal ganglion cell complex and its sensitivity. MATERIALS AND METHODS: In total, 104 glaucomatous eyes of 89 patients with a confirmed 24-2 visual field, were measured by superimposing the visual field, using imaging software, with the Wide 40° by 30° measurements of retinal ganglion cell complex obtained from the Topcon(©) 3D 2000 OCT, after upward adjustment, inversion and scaling...
November 17, 2016: Journal Français D'ophtalmologie
Mafalda Mota, Fernando T Vaz, Mário Ramalho, Catarina Pedrosa, Maria Lisboa, Paulo Kaku, Florindo Esperancinha
AIM: To determine the relationship between macular thickness (MT) and visual field (VF) parameters, as well as with changes in the retinal nerve fiber layer (RNFL) thickness in patients with glaucoma and ocular hypertension (OH). MATERIALS AND METHODS: Cross-sectional statistical analysis of spectral domain optical coherence tomography (SD-OCT) compared with several VF parameters (mean defect - MD and loss variance - LV), in a nonrandom sample of 70 eyes from patients with glaucoma or OH...
September 2016: Journal of Current Glaucoma Practice
Rajesh S Kumar, Neha Anegondi, Rachana S Chandapura, Suria Sudhakaran, Sujatha V Kadambi, Harsha L Rao, Tin Aung, Abhijit Sinha Roy
Purpose: To determine the discriminant function of optical coherence tomography angiography (OCTA) by disease severity in glaucoma. Methods: In this prospective, observational cross-sectional study, all subjects underwent visual fields, retinal nerve fiber layer (RNFL) measurements, and OCTA imaging. Local fractal analysis was applied to OCTA images (radial peripapillary capillaries [RPC] layer). Vessel density en face and inside the disc and spacing between large and small vessels were quantified...
November 1, 2016: Investigative Ophthalmology & Visual Science
Snezhina S Kostianeva, Marieta I Konareva-Kostianeva, Marin A Atanassov
AIM: To assess relationships between functional changes in visual field and structural changes in advanced open-angle glaucoma (OAG) found using spectral-domain optical coherence tomography (SD-OCT). METHODS: Thirty-one eyes of 25 patients with OAG were included in this study. Besides the routine ophthalmological exam the patients underwent standard automated perimetry (SAP) (Humphrey Field Analyzer) and SD-OCT (RTVue-100) performed within 6 months. The global perimetric indices in the study group were as follows: mean deviation (MD) 12...
September 1, 2016: Folia Medica
J Ahn, I S Yun, H G Yoo, J-J Choi, M Lee
PurposeTo evaluate a progression-detecting algorithm for a new automated matched alternation flicker (AMAF) in glaucoma patients.MethodsOpen-angle glaucoma patients with a baseline mean deviation of visual field (VF) test>-6 dB were included in this longitudinal and retrospective study. Functional progression was detected by two VF progression criteria and structural progression by both AMAF and conventional comparison methods using optic disc and retinal nerve fiber layer (RNFL) photography. Progression-detecting performances of AMAF and the conventional method were evaluated by an agreement between functional and structural progression criteria...
September 23, 2016: Eye
Aparna Rao, Komal Agarwal, Harika Mudunuri, Debananda Padhy, Avik K Roy, Sujoy Mukherjee
PURPOSE OF THE STUDY: The purpose of the study was to evaluate retinal vessel diameter in age-matched normal tension glaucoma (NTG) and primary open angle glaucoma (POAG) eyes with hemifield involvement. METHODS: Fundus photographs of patients with hemifield defect, good visibility of retinal nerve fiber layer defect, and vessels were compared with 30 controls. One eye of each patient (28 NTG and 30 POAG) was randomly chosen for analysis using Image J software by different clinicians at 2 levels...
January 2017: Journal of Glaucoma
Milan Sonka, Michael D Abràmoff
Clinical acceptance of 3-D OCT retinal imaging brought rapid development of quantitative 3-D analysis of retinal layers, vasculature, retinal lesions as well as facilitated new research in retinal diseases. One of the cornerstones of many such analyses is segmentation and thickness quantification of retinal layers and the choroid, with an inherently 3-D simultaneous multi-layer LOGISMOS (Layered Optimal Graph Image Segmentation for Multiple Objects and Surfaces) segmentation approach being extremely well suited for the task...
October 2016: Medical Image Analysis
Kazuyuki Hirooka, Saeko Izumibata, Kaori Ukegawa, Eri Nitta, Akitaka Tsujikawa
This study aimed to evaluate the relationship between glaucoma progression and estimates of the retinal ganglion cells (RGCs) obtained by combining structural and functional measurements in patients with glaucoma.In the present observational cohort study, we examined 116 eyes of 62 glaucoma patients. Using Cirrus optical coherence tomography (OCT), a minimum of 5 serial retinal nerve fiber layer (RNFL) measurements were performed in all eyes. There was a 3-year separation between the first and last measurements...
July 2016: Medicine (Baltimore)
Lukas Reznicek, Daniel Muth, Michaela Vogel, Christoph Hirneiß
PURPOSE: To evaluate the relationship between functional parameters of repeated flicker-defined form perimetry (FDF) and structural parameters of spectral-domain optical coherence tomography (SD-OCT) in glaucoma suspects with normal findings in achromatic standard automated perimetry (SAP). METHODS: Patients with optic nerve heads (ONH) clinically suspicious for glaucoma and normal SAP findings were enrolled in this prospective study. Each participant underwent visual field (VF) testing with FDF perimetry, using the Heidelberg Edge Perimeter (HEP, Heidelberg Engineering, Heidelberg, Germany) at two consecutive visits...
July 15, 2016: Current Eye Research
Hideo Nakanishi, Tadamichi Akagi, Kenji Suda, Tomoko Hasegawa, Hiroshi Yamada, Satoshi Yokota, Munemitsu Yoshikawa, Yuto Iida, Hanako Ohashi Ikeda, Satoshi Morooka, Kenji Ishihara, Nagahisa Yoshimura
PURPOSE: The purpose of this study was to cluster the test points of the combined 24-2 and 10-2 visual fields (VFs) and circumpapillary retinal nerve fiber layer thickness (cpRNFLT) sectors using explanatory factor analyses (EFAs). The correlations between the VF clusters and cpRNFLT clusters were determined, and a new function-structure relationship map was determined. METHODS: Two hundred fifty-four eyes of 166 subjects (13 normal eyes and 241 eyes with glaucoma) were studied retrospectively...
June 1, 2016: Investigative Ophthalmology & Visual Science
Nicholas A Moore, Alon Harris, Scott Wentz, Alice Chandra Verticchio Vercellin, Priyanka Parekh, Joshua Gross, Rehan M Hussain, Claudia Thieme, Brent Siesky
BACKGROUND/AIMS: Previous studies suggest that vascular abnormalities are involved in the pathogenesis of open-angle glaucoma. This study aims to examine the relationship of baseline retrobulbar blood flow measurements with functional and structural glaucomatous progression in patients with open-angle glaucoma over 4 years. METHODS: In this study, 112 patients with open-angle glaucoma were examined at baseline and 78 with retrobulbar blood flow assessments were followed to 4 years...
June 13, 2016: British Journal of Ophthalmology
Antara Banerjee, Subhadip Chakraborty, Abhijit Chakraborty, Saikat Chakrabarti, Kunal Ray
Glaucoma, the leading cause of irreversible blindness, appears in various forms. Mutations in CYP1B1 result in primary congenital glaucoma (PCG) by an autosomal recessive mode of inheritance while it acts as a modifier locus for primary open angle glaucoma (POAG). We investigated the molecular basis of the variable phenotypes resulting from the defects in CYP1B1 by using subclones of 23 CYP1B1 mutants reported in glaucoma patients, in a cell based system by measuring the dual activity of the enzyme to metabolize both retinol and 17β-estradiol...
2016: PloS One
Nabanita Barua, Chitra Sitaraman, Sonu Goel, Chandana Chakraborti, Sonai Mukherjee, Hemandra Parashar
CONTEXT: Analysis of diagnostic ability of macular ganglionic cell complex and retinal nerve fiber layer (RNFL) in glaucoma. AIM: To correlate functional and structural parameters and comparing predictive value of each of the structural parameters using Fourier-domain (FD) optical coherence tomography (OCT) among primary open angle glaucoma (POAG) and ocular hypertension (OHT) versus normal population. SETTING AND DESIGN: Single centric, cross-sectional study done in 234 eyes...
April 2016: Indian Journal of Ophthalmology
Jose M Gonzalez, Minhee K Ko, Andrius Masedunskas, Young-Kwon Hong, Roberto Weigert, James C H Tan
The promise of revolutionary insights into intraocular pressure (IOP) and aqueous humor outflow homeostasis, IOP pathogenesis, and novel therapy offered by engineered mouse models has been hindered by a lack of appropriate tools for studying the aqueous drainage tissues in their original 3-dimensional (3D) environment. Advances in 2-photon excitation fluorescence imaging (TPEF) combined with availability of modalities such as transgenic reporter mice and intravital dyes have placed us on the cusp of unlocking the potential of the mouse model for unearthing insights into aqueous drainage structure and function...
May 11, 2016: Experimental Eye Research
Yiqun Chen, Paul Hahn, Frank A Sloan
PURPOSE: To document recent trends in visual function among the United States population aged 70+ years and investigate how the trends can be explained by inter-temporal changes in: (1) population sociodemographic characteristics, and chronic disease prevalence, including eye diseases (compositional changes); and (2) effects of the above factors on visual function (structural changes). METHODS: Data from the 1995 Asset and Health Dynamics among the Oldest Old (AHEAD) and the 2010 Health and Retirement Study (HRS) were merged with Medicare Part B claims in the interview years and the 2 previous years...
June 2016: Ophthalmic Epidemiology
M V Zueva, M U Arapiev, I V Tsapenko, D N Lovpache, N M Maglakelidze, E P Lantukh
UNLABELLED: Early diagnosis of primary open-angle glaucoma (POAG) is closely connected with detection of normal age-related changes in the retina. It is also essential to develop reliable methods for quantitative evaluation of retinal nerve fiber layer (RNFL) thickness and retinal ganglion cells (RGCs) structure and function as well as to extend opportunities for inter-instrumental comparisons. AIM: to assess the function of RGCs from parvo- and magnocellular pathways by means of pattern electroretinography and to evaluate the degree of retinal sensitivity loss and RNFL thickness using new methods of analysis in normal aging and the early stage of POAG...
January 2016: Vestnik Oftalmologii
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