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Structure Function Analysis in Glaucoma

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https://www.readbyqxmd.com/read/28771565/segmented-inner-plexiform-layer-thickness-as-a-potential-biomarker-to-evaluate-open-angle-glaucoma-dendritic-degeneration-of-retinal-ganglion-cell
#1
Eun Kyoung Kim, Hae-Young Lopilly Park, Chan Kee Park
PURPOSE: To evaluate the changes of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and ganglion cell-inner plexiform layer (GCIPL) thicknesses and compare structure-function relationships of 4 retinal layers using spectral-domain optical coherence tomography (SD-OCT) in macular region of glaucoma patients. METHODS: In cross-sectional study, a total of 85 eyes with pre-perimetric to advanced glaucoma and 26 normal controls were enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/28736474/phenotype-analysis-of-early-risk-factors-from-electronic-medical-records-improves-image-derived-diagnostic-classifiers-for-optic-nerve-pathology
#2
Shikha Chaganti, Kunal P Nabar, Katrina M Nelson, Louise A Mawn, Bennett A Landman
We examine imaging and electronic medical records (EMR) of 588 subjects over five major disease groups that affect optic nerve function. An objective evaluation of the role of imaging and EMR data in diagnosis of these conditions would improve understanding of these diseases and help in early intervention. We developed an automated image-processing pipeline that identifies the orbital structures within the human eyes from computed tomography (CT) scans, calculates structural size, and performs volume measurements...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28722309/long-term-outcomes-after-acute-primary-angle-closure-of-caucasian-chronic-angle-closure-glaucoma-cacg-patients
#3
Antonio Maria Fea, Laura Dallorto, Carlo Lavia, Giulia Pignata, Teresa Rolle, Tin Aung
IMPORTANCE: There is a lack of information about long term results of chronic angle closure glaucoma (CACG) following an acute primary angle closure (APAC) in Caucasian patients PURPOSE: To report morphological and functional long-term data of CACG eyes following a monolateral APAC attack and to provide a comparison with their fellow eyes DESIGN: Observational retrospective case series (Clinica Oculistica Universitaria, Ospedale Oftalmico, Turin) PARTICIPANTS: 57 consecutive patients (114 eyes) underwent long term follow-up analysis...
July 19, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28717139/relationship-between-retinal-inner-nuclear-layer-thickness-and-severity-of-visual-field-loss-in-glaucoma
#4
Eun Kyoung Kim, Hae-Young Lopilly Park, Chan Kee Park
Glaucoma is a disease characterized by pathologic changes in inner retinal layers, which are comprised of retinal ganglion cells (RGCs). As retinal ganglion cells (RGCs) cross over other retinal neurons that are connected by synapses, it is meaningful to investigate the outer retinal changes in glaucoma. We evaluated the association between thicknesses of segmented retinal layers in macular region and severity of visual field loss in open-angle glaucoma (OAG). This study involved 103 glaucomatous eyes. Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), and outer nuclear layer (ONL) thicknesses were measured at the macular level using the Spectral-domain optical coherence tomography with segmentation software...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28614218/usefulness-of-frequency-doubling-technology-perimetry-24-2-in-glaucoma-with-parafoveal-scotoma
#5
Kyoung In Jung, Eun Kyoung Kim, Chan Kee Park
The standard automated perimetry (SAP) 24-2 test cannot adequately test the paracentral region because test points are located sparsely in macular area where is crowded with retinal ganglion cells (RGCs), even though paracentral scotoma is clinically related to a risk of losing visual function. More sensitive visual field (VF) tests are needed to assess paracentral VF defects precisely. We investigated the structure-function relationship on the SAP 10-2 test and the frequency doubling technology (FDT) 24-2 test as well as the SAP 24-2 test in glaucoma with parafoveal scotoma (PFS)...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28593391/wavelet-decomposition-analysis-in-the-two-flash-multifocal-erg-in-early-glaucoma-a-comparison-to-ganglion-cell-analysis-and-visual-field
#6
Livia M Brandao, Matthias Monhart, Andreas Schötzau, Anna A Ledolter, Anja M Palmowski-Wolfe
PURPOSE: To further improve analysis of the two-flash multifocal electroretinogram (2F-mfERG) in glaucoma in regard to structure-function analysis, using discrete wavelet transform (DWT) analysis. METHODS: Sixty subjects [35 controls and 25 primary open-angle glaucoma (POAG)] underwent 2F-mfERG. Responses were analyzed with the DWT. The DWT level that could best separate POAG from controls was compared to the root-mean-square (RMS) calculations previously used in the analysis of the 2F-mfERG...
August 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28576383/cholesterol-metabolism-and-glaucoma-modulation-of-muller-cell-membrane-organization-by-24s-hydroxycholesterol
#7
Ségolène Gambert, Pierre-Henry Gabrielle, Elodie Masson, Elise Leger-Charnay, Arthur Ferrerro, Arthur Vannier, Clément Gendrault, Méline Lachot, Catherine Creuzot-Garcher, Alain Bron, Stéphane Gregoire, Laurent Leclere, Lucy Martine, Géraldine Lucchi, Caroline Truntzer, Delphine Pecqueur, Lionel Bretillon
Glaucoma is a progressive and irreversible blinding neuropathy that is characterized by the loss of retinal ganglion cells (RGCs). Muller Glial Cell (MGC) activation is induced in retinal gliosis. MGCs are the most numerous glial cells in the retina and one of their roles is to sustain cholesterol homeostasis. 24S-hydroxycholesterol (24S-OHC) is one of the form of cholesterol elimination from the retina and is overexpressed during glaucoma. The objective of this study was to determine whether 24S-OHC triggers MGC membrane dynamics involving lipid rafts and contributes to gliosis at early and late time points...
May 30, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28545121/measurement-of-macular-structure-function-relationships-using-spectral-domain-optical-coherence-tomography-sd-oct-and-pattern-electroretinograms-perg
#8
Keunheung Park, Jinmi Kim, Jiwoong Lee
BACKGROUND: Retinal ganglion cell (RGC) death is a common cause of loss of vision during glaucoma. Pattern electroretinogram (PERG) is an objective measure of the central retinal function that correlates with macular GCL thickness. The aim of this study is to determine possible relationships between the N95 amplitude of pattern electroretinogram (PERGamp) and macular ganglion cell/inner plexiform layer thickness (GCIPLT). METHODS AND FINDINGS: This was a retrospective and comparative study including 74 glaucoma patients (44 early stage and 30 advanced stage cases) and 66 normal control subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28532392/diagnostic-performance-of-isolated-check-visual-evoked-potential-versus-retinal-ganglion-cell-inner-plexiform-layer-analysis-in-early-primary-open-angle-glaucoma
#9
XiangWu Chen, YingXi Zhao
BACKGROUND: The purpose of this study was to compare the diagnostic performance of isolated-check visual evoked potential (icVEP) with that of retinal ganglion cell-inner plexiform layer (GCILP) analysis using optical coherence tomography (OCT). METHODS: A total of 45 patients were enrolled: 25 patients with open-angle glaucoma and 20 healthy patients. All patients underwent a complete ophthalmological examination. Moreover, the OCT examination was used to analyze the structures of the GCIPL...
May 22, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28439944/using-perimetric-data-to-estimate-ganglion-cell-loss-for-detecting-progression-of-glaucoma-a-comparison-of-models
#10
Derek A Price, William H Swanson, Douglas G Horner
PURPOSE: Models relating perimetric sensitivities to ganglion cell numbers have been proposed for combining structural and functional measures from patients with glaucoma. Here we compared seven models for ability to differentiate progressing and stable patients, testing the hypothesis that the model incorporating local spatial scale would have the best performance. METHODS: The models were compared for the United Kingdom Glaucoma Treatment Study (UKGTS) data for the right eyes of 489 patients recently diagnosed with glaucoma...
July 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28386709/in-silico-analysis-of-five-missense-mutations-in-cyp1b1-gene-in-pakistani-families-affected-with-primary-congenital-glaucoma
#11
Sabika Firasat, Haiba Kaul, Usman Ali Ashfaq, Sobia Idrees
PURPOSE: The purpose of this study was to characterize the five missense mutations in CYP1B1 gene identified in Pakistani families affected with primary congenital glaucoma (PCG) using various bioinformatics and protein modeling tools. METHODS: We previously reported four novel missense mutations in CYP1B1 gene segregating in consanguineous Pakistani families. These mutations were identified by direct sequencing of all coding exons, the exon-intron boundaries and the 5' untranslated region of CYP1B1 using genomic DNA from affected and unaffected family members...
April 6, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28280945/influence-of-intraocular-pressure-reduction-on-progression-of-normal-tension-glaucoma-with-myopic-tilted-disc-and-associated-risk-factors
#12
Bo Ram Seol, Soa Kim, Dong Myung Kim, Ki Ho Park, Jin Wook Jeoung, Seok Hwan Kim
Purpose To evaluate the influence of intraocular pressure (IOP) reduction on progression of normal-tension glaucoma (NTG) with myopic tilted disc and to demonstrate the associated risk factors. METHODS: The medical records on 109 eyes of 109 NTG patients with myopic tilted discs who were followed up for more than 5 years and treated with topical medications were reviewed. Glaucoma progression was defined according to either structural or functional deterioration. Patients were divided into tertile groups according to the percent IOP reduction from the baseline, and the cumulative probability of NTG nonprogression of the upper- and lower-tertile groups was compared using Kaplan-Meier survival analysis...
March 9, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28248867/structural-and-functional-brain-changes-in-early-and-mid-stage-primary-open-angle-glaucoma-using-voxel-based-morphometry-and-functional-magnetic-resonance-imaging
#13
Ming-Ming Jiang, Qing Zhou, Xiao-Yong Liu, Chang-Zheng Shi, Jian Chen, Xiang-He Huang
To investigate structural and functional brain changes in patients with primary open-angle glaucoma (POAG) by using voxel-based morphometry based on diffeomorphic anatomical registration through exponentiated Lie algebra (VBM-DARTEL) and blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI), respectively.Thirteen patients diagnosed with POAG and 13 age- and sex-matched healthy controls were enrolled in the study. For each participant, high-resolution structural brain imaging and blood flow imaging were acquired on a 3...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28169921/predicting-the-magnitude-of-functional-and-structural-damage-in-glaucoma-from-monocular-pupillary-light-responses-using-automated-pupillography
#14
Zia S Pradhan, Harsha L Rao, Narendra K Puttaiah, Sujatha V Kadambi, Srilakshmi Dasari, Hemanth B Reddy, Meena Palakurthy, Mohammed Riyazuddin, Dhanaraj A S Rao
PURPOSE: To predict the magnitude of functional damage [mean deviation (MD) on visual field examination] and structural damage [retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness on spectral domain optical coherence tomography] in glaucoma from monocular pupillary light response measurements using automated pupillography. METHODS: In total, 59 subjects (118 eyes) with either a confirmed or suspected diagnosis of glaucoma underwent automated pupillography, along with visual fields and spectral domain optical coherence tomography examinations...
May 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28161925/the-use-of-microperimetry-to-detect-functional-progression-in-non-neovascular-age-related-macular-degeneration-a-systematic-review
#15
REVIEW
Evan N Wong, Avenell L Chew, William H Morgan, Praveen J Patel, Fred K Chen
We reviewed the current literature on the ability of microperimetry to detect non-neovascular age-related macular degeneration (AMD) disease progression. The index test was retinal sensitivity measurement assessed by microperimetry and comparators were other functional measures (best-corrected and low-luminance visual acuities, and fixation stability) and structural parameters [retinal thickness, choroidal thickness, and area of geographic atrophy (GA) determined by color fundus photographs, short-wave or near-infrared fundus autofluorescence]...
January 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28161916/the-pathway-from-genes-to-gene-therapy-in-glaucoma-a-review-of-possibilities-for-using-genes-as-glaucoma-drugs
#16
REVIEW
Teresa Borrás
Treatment of diseases with gene therapy is advancing rapidly. The use of gene therapy has expanded from the original concept of re-placing the mutated gene causing the disease to the use of genes to con-trol nonphysiological levels of expression or to modify pathways known to affect the disease. Genes offer numerous advantages over conventional drugs. They have longer duration of action and are more specific. Genes can be delivered to the target site by naked DNA, cells, nonviral, and viral vectors. The enormous progress of the past decade in molecular bi-ology and delivery systems has provided ways for targeting genes to the intended cell/tissue and safe, long-term vectors...
January 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28152070/retinal-vessel-density-from-optical-coherence-tomography-angiography-to-differentiate-early-glaucoma-pre-perimetric-glaucoma-and-normal-eyes
#17
Handan Akil, Alex S Huang, Brian A Francis, Sirinivas R Sadda, Vikas Chopra
PURPOSE: To evaluate optic nerve vascular density using swept source optical coherence tomography angiography (OCTA) in patients with early primary open angle glaucoma (POAG), pre-perimetric glaucoma and normal eyes. METHODS: This is a prospective, observational study including 56 eyes in total and divided into 3 groups; 20 eyes with mild POAG, 20 pre-perimetric glaucoma eyes, and 16 age-matched normal eyes as controls. The optic disc region was imaged by a 1050-nm-wavelength swept-source OCT system (DRI OCT Triton, TOPCON)...
2017: PloS One
https://www.readbyqxmd.com/read/28120229/phytochemistry-of-cannabis-sativa-l
#18
REVIEW
Mahmoud A ElSohly, Mohamed M Radwan, Waseem Gul, Suman Chandra, Ahmed Galal
Cannabis (Cannabis sativa, or hemp) and its constituents-in particular the cannabinoids-have been the focus of extensive chemical and biological research for almost half a century since the discovery of the chemical structure of its major active constituent, Δ(9)-tetrahydrocannabinol (Δ(9)-THC). The plant's behavioral and psychotropic effects are attributed to its content of this class of compounds, the cannabinoids, primarily Δ(9)-THC, which is produced mainly in the leaves and flower buds of the plant...
2017: Progress in the Chemistry of Organic Natural Products
https://www.readbyqxmd.com/read/28033298/retinal-and-choroidal-oxygen-saturation-of-the-optic-nerve-head-in-open-angle-glaucoma-subjects-by-multispectral-imaging
#19
Gai-Yun Li, Samer Abdo Al-Wesabi, Hong Zhang
The aim of this study was to determine whether differences exist in oxygen supply to the optic nerve head (ONH) from the retinal and choroidal vascular layers in patients with primary open angle glaucoma (POAG) using multispectral imaging (MSI).This ia an observational, cross-sectional study.Multispectral images were acquired from 38 eyes of 19 patients with POAG, and 42 healthy eyes from 21 matched volunteers with Annidis' RHA multispectral digital ophthalmoscopy. Superficial and deeper oxygen saturation of the optic disc was represented by the mean gray scale values on the retinal and choroidal oxy-deoxy maps, respectively...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27898471/green-disease-in-optical-coherence-tomography-diagnosis-of-glaucoma
#20
REVIEW
Mohamed S Sayed, Michael Margolis, Richard K Lee
PURPOSE OF REVIEW: Optical coherence tomography (OCT) has become an integral component of modern glaucoma practice. Utilizing color codes, OCT analysis has rendered glaucoma diagnosis and follow-up simpler and faster for the busy clinician. However, green labeling of OCT parameters suggesting normal values may confer a false sense of security, potentially leading to missed diagnoses of glaucoma and/or glaucoma progression. RECENT FINDINGS: Conditions in which OCT color coding may be falsely negative (i...
March 2017: Current Opinion in Ophthalmology
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