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JOURNAL ARTICLE
Anelisa Jaca, Chanelle Mulopo, Charles Shey Wiysonge, Bey-Marrié Schmidt
Knowledge translation (KT) is a set of activities or processes for synthesising, disseminating, and applying research evidence in decision-making for the benefit of society. For KT to be successful, it is paramount for researchers to play an active role in encouraging evidence uptake and use in decision-making. We carried out a mapping exercise and interviews with research cluster heads at Cochrane South Africa (CSA) of the KT activities and processes being implemented (or are planned for implementation). We organized the mapping and interview results according to the KT themes described in the Cochrane KT framework...
2023: Pan African Medical Journal
#22
JOURNAL ARTICLE
Sara Cooper, Charles S Wiysonge
Vaccine hesitancy has gained renewed attention as an important public health concern worldwide. Against this backdrop, over the last decade, we have conducted various qualitative, social science studies with the broad shared aim of better understanding this complex phenomenon. This has included various Cochrane systematic reviews of qualitative research globally, systematic reviews of qualitative research in Africa, and primary research studies in South Africa. These studies have also explored vaccine hesitancy for various vaccines, including routine childhood vaccination, HPV vaccination and other routine vaccinations for adolescents, and, most recently, COVID-19 vaccination...
June 26, 2023: Vaccines
#23
REVIEW
Joseph Chukwudi Okeibunor, Anelisa Jaca, Chinwe Juliana Iwu-Jaja, Ngozi Idemili-Aronu, Housseynou Ba, Zukiswa Pamela Zantsi, Asiphe Mavis Ndlambe, Edison Mavundza, Derrick Muneene, Charles Shey Wiysonge, Lindiwe Makubalo
BACKGROUND: Artificial intelligence (AI) is a broad outlet of computer science aimed at constructing machines capable of simulating and performing tasks usually done by human beings. The aim of this scoping review is to map existing evidence on the use of AI in the delivery of medical care. METHODS: We searched PubMed and Scopus in March 2022, screened identified records for eligibility, assessed full texts of potentially eligible publications, and extracted data from included studies in duplicate, resolving differences through discussion, arbitration, and consensus...
2023: Frontiers in Public Health
#24
REVIEW
Xiaoqin Wang, Omar Dewidar, Anita Rizvi, Jimmy Huang, Payaam Desai, Rebecca Doyle, Elizabeth Ghogomu, Tamara Rader, Stuart G Nicholls, Alba Antequera, Alison Krentel, Beverley Shea, Billie-Jo Hardy, Catherine Chamberlain, Charles S Wiysonge, Cindy Feng, Clara Juando-Prats, Daeria O Lawson, Ekwaro A Obuku, Elizabeth Kristjansson, Erik von Elm, Harry Wang, Holly Ellingwood, Hugh Sharma Waddington, Jacqueline Ramke, Janet Elizabeth Jull, Janet Hatcher-Roberts, Janice Tufte, Julian Little, Lawrence Mbuagbaw, Laura Weeks, Loveline Lum Niba, Luis Gabriel Cuervo, Luke Wolfenden, Mwenya Kasonde, Marc T Avey, Melissa K Sharp, Michael Johnson Mahande, Miriam Nkangu, Olivia Magwood, Peter Craig, Peter Tugwell, Sarah Funnell, S G Noorduyn, Tamara Kredo, Tanya Horsley, Taryn Young, Tomas Pantoja, Zulfiqar Bhutta, Andrea Martel, Vivian A Welch
OBJECTIVE: To evaluate the support from the available guidance on reporting of health equity in research for our candidate items and to identify additional items for the STROBE (Strengthening Reporting of Observational studies in Epidemiology)-Equity extension. STUDY DESIGN AND SETTING: We conducted a scoping review by searching Embase, MEDLINE, CINAHL, Cochrane Methodology Register, LILACS, and Caribbean Centre on Health Sciences Information up to January 2022...
June 15, 2023: Journal of Clinical Epidemiology
#25
REVIEW
Patrick D M C Katoto, Liliane N Byamungu, Amanda S Brand, Jacques L Tamuzi, Mireille A M Kakubu, Charles S Wiysonge, Glenda Gray
Myocarditis and pericarditis are frequent complications of COVID-19, but have also been reported following vaccination against COVID-19 in adolescents. To build vaccine confidence and inform policy, we characterized the incidence of myocarditis/pericarditis in adolescents following BNT162b2 vaccination and explored the association with dose and sex. We searched national and international databases for studies reporting the incidence of myocarditis/pericarditis following BNT162b2 vaccination as the primary endpoint...
June 9, 2023: NPJ Vaccines
#26
REVIEW
Patrick Dmc Katoto, Jacques L Tamuzi, Amanda S Brand, Diana M Marangu, Liliane N Byamungu, Charles S Wiysonge, Glenda Gray
The rapid emergence of COVID-19 variants of concern (VOCs) has hindered vaccine uptake. To inform policy, we investigated the effectiveness of the BNT162b2 vaccination among adolescents against symptomatic and severe COVID-19 diseases using mostly real-world data (15 studies). We searched international databases until May 2022 and used Cochrane's risk of bias tools for critical appraisal. Random effects models were used to examine overall vaccine effectiveness (VE) across studies (general inverse-variance) and the effect of circulating VOCs on VE (log relative ratio and VE)...
June 5, 2023: Human Vaccines & Immunotherapeutics
#27
REVIEW
Charles I Okwundu, Abiola Olowoyeye, Olalekan A Uthman, Johan Smith, Charles S Wiysonge, Vinod K Bhutani, Michelle Fiander, Kanekal S Gautham
BACKGROUND: Jaundice is a very common condition in newborns, affecting up to 60% of term newborns and 80% of preterm newborns in the first week of life. Jaundice is caused by increased bilirubin in the blood from the breakdown of red blood cells. The gold standard for measuring bilirubin levels is obtaining a blood sample and processing it in a laboratory. However, noninvasive transcutaneous bilirubin (TcB) measurement devices are widely available and used in many settings to estimate total serum bilirubin (TSB) levels...
May 9, 2023: Cochrane Database of Systematic Reviews
#28
JOURNAL ARTICLE
Patrick Dmc Katoto, Mireille Am Kakubu, Jacques L Tamuzi, Amanda S Brand, Adaeze Ayuk, Liliane N Byamungu, Charles S Wiysonge, Glenda Gray
BACKGROUND: This study aimed to evaluate the safety and effectiveness of the BNT162b2 vaccine in immunocompromised adolescents and young adults. RESEARCH DESIGN AND METHODS: The study conducted a meta-analysis of post-marketing studies examining BNT162b2 vaccination efficacy and safety among immunocompromised adolescents and young adults worldwide. The review included nine studies and 513 individuals aged between 12 and 24.3 years. The study used a random effect model to estimate pooled proportions, log relative risk, and mean difference, and assessed heterogeneity using the I2 test...
2023: Expert Review of Vaccines
#29
REVIEW
Edison J Mavundza, Sara Cooper, Charles S Wiysonge
A Cochrane review which explored the factors that influence caregivers' views and practices around routine childhood vaccines worldwide was conducted by Cooper and colleagues. After sampling 154 studies that met their inclusion criteria, the authors included 27 studies in their synthesis, of which 6 were from Africa. The aim of the current review was to synthesise all 27 studies conducted in Africa. We wanted to determine if the inclusion of additional African studies will change any of the themes, concepts or theory generated in the Cochrane review...
March 1, 2023: Vaccines
#30
JOURNAL ARTICLE
Sarah Funnell, Janet Jull, Lawrence Mbuagbaw, Vivian Welch, Omar Dewidar, Xiaoqin Wang, Miranda Lesperance, Elizabeth Ghogomu, Anita Rizvi, Elie A Akl, Marc T Avey, Alba Antequera, Zulfiqar A Bhutta, Catherine Chamberlain, Peter Craig, Luis Gabriel Cuervo, Alassane Dicko, Holly Ellingwood, Cindy Feng, Damian Francis, Regina Greer-Smith, Billie-Jo Hardy, Matire Harwood, Janet Hatcher-Roberts, Tanya Horsley, Clara Juando-Prats, Mwenya Kasonde, Michelle Kennedy, Tamara Kredo, Alison Krentel, Elizabeth Kristjansson, Laurenz Langer, Julian Little, Elizabeth Loder, Olivia Magwood, Michael Johnson Mahande, G J Melendez-Torres, Ainsley Moore, Loveline Lum Niba, Stuart G Nicholls, Miriam Nguilefem Nkangu, Daeria O Lawson, Ekwaro Obuku, Patrick Okwen, Tomas Pantoja, Jennifer Petkovic, Mark Petticrew, Kevin Pottie, Tamara Rader, Jacqueline Ramke, Alison Riddle, Larissa Shamseer, Melissa Sharp, Bev Shea, Peter Tanuseputro, Peter Tugwell, Janice Tufte, Erik Von Elm, Hugh Sharma Waddington, Harry Wang, Laura Weeks, George Wells, Howard White, Charles Shey Wiysonge, Luke Wolfenden, Taryn Young
BACKGROUND: Addressing persistent and pervasive health inequities is a global moral imperative, which has been highlighted and magnified by the societal and health impacts of the COVID-19 pandemic. Observational studies can aid our understanding of the impact of health and structural oppression based on the intersection of gender, race, ethnicity, age and other factors, as they frequently collect this data. However, the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guideline, does not provide guidance related to reporting of health equity...
March 30, 2023: International Journal for Equity in Health
#31
JOURNAL ARTICLE
Marilyn A Couch, Patrick D M C Katoto, Samuel Fikiri Cinini, Charles S Wiysonge
Concerns regarding the safety of COVID-19 vaccination have caused hesitancy and lowered uptake globally. While vaccine hesitancy is documented globally, some continents, countries, ethnic groups and age groups are disproportionately affected, resulting in significant global inequities. To date, Africa has the lowest COVID-19 coverage globally, with only 22% of its population completely vaccinated. It might be argued that the difficulty with COVID-19 vaccine acceptance in Africa was triggered by the anxiety created by misinformation on social media platforms, particularly with the misinformation regarding depopulating Africa, given the significance of maternity in the continent...
February 20, 2023: Human Vaccines & Immunotherapeutics
#32
JOURNAL ARTICLE
Chukwudi A Nnaji, Charles S Wiysonge, Sara Cooper, Asanda Mayeye, Lucy Luphondo, Thobile Mabuya, Ntomboxolo Kalui, Maia Lesosky, Duduzile Ndwandwe
This study aimed to explore the contextual factors that may be associated with missed opportunities for vaccination (MOV) from the perspectives of healthcare providers and caregivers attending primary healthcare facilities in the Cape Town Metro Health District, South Africa. The ultimate goal of the assessment was to help inform the design and implementation of a contextually appropriate quality improvement programme targeted at reducing MOV in primary healthcare settings. We used a theory-informed exploratory qualitative research design involving focus group discussions with caregivers of children aged 0-23 months; and in-depth interviews of facility staff...
January 5, 2023: Human Vaccines & Immunotherapeutics
#33
JOURNAL ARTICLE
S Cooper, B-M Schmidt, A Swartz, C J Colvin, N Leon, E Z Sambala, A Jaca, N Gloeck, N Pillay, T Kredo, C Wiysonge
We summarise a Cochrane review of qualitative evidence that explored parents' views and practices around routine childhood vaccination, and provide implications for research and practice that are relevant to the South African (SA) context. Many public health interventions to encourage vaccination are informed by an assumption that vaccine hesitancy is due to a lack of knowledge or irrational forms of thinking. The findings from this review suggest that childhood vaccination views and practices are complex social processes that are shaped by multiple factors and carry a variety of meanings...
December 1, 2022: South African Medical Journal
#34
JOURNAL ARTICLE
Duduzile Ndwandwe, Sinazo Runeyi, Lindi Mathebula, Charles Wiysonge
BACKGROUND: Rotavirus is a primary infectious virus causing childhood diarrhoea and is associated with significant mortality in children. Three African countries (Nigeria, the Democratic Republic of Congo, and Angola) are among the five countries that account for 50% of all diarrheal-related deaths worldwide. This indicates that much needs to be done to reduce this burden. The World Health Organization International Clinical Trial Registry Platform (WHO ICTRP) is a global repository for primary registries reporting on clinical trials...
November 17, 2022: Trials
#35
JOURNAL ARTICLE
Patrick D M C Katoto, Amanda S Brand, Liliane N Byamungu, Jacques L Tamuzi, Tamirirashe C Mahwire, Marcel K Kitenge, Charles S Wiysonge, Glenda Gray
The COVID-19 pandemic has severely affected adolescents. Safe and effective vaccines are pivotal tools in controlling this pandemic. We reviewed the safety profile of the BNT162b2 COVID-19 vaccine in adolescents using mostly real-world data to assist decision-making. We used random-effects model meta-analysis to derive pooled rates of single or grouped adverse events following immunization (AEFI) after each primary and booster dose, as well as after combining all doses. Reporting on over one million participants with safety data were included...
November 11, 2022: Human Vaccines & Immunotherapeutics
#36
JOURNAL ARTICLE
Sarah Wulf Hanson, Cristiana Abbafati, Joachim G Aerts, Ziyad Al-Aly, Charlie Ashbaugh, Tala Ballouz, Oleg Blyuss, Polina Bobkova, Gouke Bonsel, Svetlana Borzakova, Danilo Buonsenso, Denis Butnaru, Austin Carter, Helen Chu, Cristina De Rose, Mohamed Mustafa Diab, Emil Ekbom, Maha El Tantawi, Victor Fomin, Robert Frithiof, Aysylu Gamirova, Petr V Glybochko, Juanita A Haagsma, Shaghayegh Haghjooy Javanmard, Erin B Hamilton, Gabrielle Harris, Majanka H Heijenbrok-Kal, Raimund Helbok, Merel E Hellemons, David Hillus, Susanne M Huijts, Michael Hultström, Waasila Jassat, Florian Kurth, Ing-Marie Larsson, Miklós Lipcsey, Chelsea Liu, Callan D Loflin, Andrei Malinovschi, Wenhui Mao, Lyudmila Mazankova, Denise McCulloch, Dominik Menges, Noushin Mohammadifard, Daniel Munblit, Nikita A Nekliudov, Osondu Ogbuoji, Ismail M Osmanov, José L Peñalvo, Maria Skaalum Petersen, Milo A Puhan, Mujibur Rahman, Verena Rass, Nickolas Reinig, Gerard M Ribbers, Antonia Ricchiuto, Sten Rubertsson, Elmira Samitova, Nizal Sarrafzadegan, Anastasia Shikhaleva, Kyle E Simpson, Dario Sinatti, Joan B Soriano, Ekaterina Spiridonova, Fridolin Steinbeis, Andrey A Svistunov, Piero Valentini, Brittney J van de Water, Rita van den Berg-Emons, Ewa Wallin, Martin Witzenrath, Yifan Wu, Hanzhang Xu, Thomas Zoller, Christopher Adolph, James Albright, Joanne O Amlag, Aleksandr Y Aravkin, Bree L Bang-Jensen, Catherine Bisignano, Rachel Castellano, Emma Castro, Suman Chakrabarti, James K Collins, Xiaochen Dai, Farah Daoud, Carolyn Dapper, Amanda Deen, Bruce B Duncan, Megan Erickson, Samuel B Ewald, Alize J Ferrari, Abraham D Flaxman, Nancy Fullman, Amiran Gamkrelidze, John R Giles, Gaorui Guo, Simon I Hay, Jiawei He, Monika Helak, Erin N Hulland, Maia Kereselidze, Kris J Krohn, Alice Lazzar-Atwood, Akiaja Lindstrom, Rafael Lozano, Deborah Carvalho Malta, Johan Månsson, Ana M Mantilla Herrera, Ali H Mokdad, Lorenzo Monasta, Shuhei Nomura, Maja Pasovic, David M Pigott, Robert C Reiner, Grace Reinke, Antonio Luiz P Ribeiro, Damian Francesco Santomauro, Aleksei Sholokhov, Emma Elizabeth Spurlock, Rebecca Walcott, Ally Walker, Charles Shey Wiysonge, Peng Zheng, Janet Prvu Bettger, Christopher J L Murray, Theo Vos
IMPORTANCE: Some individuals experience persistent symptoms after initial symptomatic SARS-CoV-2 infection (often referred to as Long COVID). OBJECTIVE: To estimate the proportion of males and females with COVID-19, younger or older than 20 years of age, who had Long COVID symptoms in 2020 and 2021 and their Long COVID symptom duration. DESIGN, SETTING, AND PARTICIPANTS: Bayesian meta-regression and pooling of 54 studies and 2 medical record databases with data for 1...
October 25, 2022: JAMA
#37
REVIEW
Elizabeth O Oduwole, Elizabeth D Pienaar, Hassan Mahomed, Charles S Wiysonge
The challenge of vaccine hesitancy, a growing global concern in the last decade, has been aggravated by the COVID-19 pandemic. The need for monitoring vaccine sentiments and early detection of vaccine hesitancy in a population recommended by the WHO calls for the availability of contextually relevant tools and measures. This scoping review covers a ten year-period from 2010-2019 which included the first nine years of the decade of vaccines and aims to give a broad overview of tools and measures, and present a summary of their nature, similarities, and differences...
July 27, 2022: Vaccines
#38
JOURNAL ARTICLE
Sara Cooper, Heidi van Rooyen, Charles S Wiysonge
It has been over a year since South Africa officially began its national COVID-19 vaccination programme. Yet, currently only half of the adult population is fully vaccinated. While supply-related challenges continue to contribute to suboptimal vaccination coverage, so too does vaccine hesitancy. Drawing on research conducted over the last year, we highlight some overarching insights around the nature and drivers of COVID-19 vaccine hesitancy in South Africa and how this complex phenomenon might be addressed...
August 22, 2022: Human Vaccines & Immunotherapeutics
#39
JOURNAL ARTICLE
Arlette Leufak Mouako, Moleen Zunza, Duduzile Ndwandwe, Olalekan Abdulrahman Uthman, Charles Shey Wiysonge
Introduction: research publications have a vital role in the scientific process, providing a strategic connection between the generation of new knowledge and its conversion into policy, practice, and positive health outcomes. There was a substantial increase in research funding in South Africa from the dawn of multi-party democracy in the mid-1990s to 2015. However, it is not known whether there was a corresponding increase in research publications from the country. Therefore, the objective of this bibliometric study was to assess trends and factors associated with health research publications from South Africa between 1996 and 2015...
2022: Pan African Medical Journal
#40
JOURNAL ARTICLE
Samuel M Alobwede, Elvis B Kidzeru, Patrick D M C Katoto, Evelyn N Lumngwena, Sara Cooper, Rene Goliath, Amanda Jackson, Charles S Wiysonge, Muki S Shey
Vaccination attitudes among healthcare workers (HCWs) predict their level of vaccination uptake and intention to recommend vaccinations to their patients. To our knowledge, no study has been conducted in South Africa to assess hesitancy toward influenza vaccines among HCWs. We adapted a questionnaire developed and validated by Betsch and colleagues and used it to conduct online and face-to-face interviews among HCWs at the start of the COVID-19 vaccine rollout. Multivariate logistic regression was used to assess predictors of influenza vaccine hesitancy...
July 25, 2022: Vaccines
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