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https://www.readbyqxmd.com/read/28208043/the-australasian-diabetes-data-network-first-national-audit-of-children-and-adolescents-with-type-1-diabetes
#1
Helen Phelan, Helen Clapin, Loren Bruns, Fergus J Cameron, Andrew M Cotterill, Jennifer J Couper, Elizabeth A Davis, Kim C Donaghue, Craig A Jefferies, Bruce R King, Richard O Sinnott, Elaine B Tham, Jerry K Wales, Timothy W Jones, Maria E Craig
OBJECTIVES: To assess glycaemic control, anthropometry and insulin regimens in a national sample of Australian children and adolescents with type 1 diabetes. DESIGN: Cross-sectional analysis of de-identified, prospectively collected data from the Australasian Diabetes Data Network (ADDN) registry. SETTING: Five paediatric diabetes centres in New South Wales, Queensland, South Australia, Victoria and Western Australia. PARTICIPANTS: Children and adolescents (aged 18 years or under) with type 1 diabetes of at least 12 months' duration for whom data were added to the ADDN registry during 2015...
February 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28100192/design-and-rationale-of-a-large-international-prospective-cohort-study-to-evaluate-the-occurrence-of-malformations-and-perinatal-neonatal-death-using-insulin-detemir-in-pregnant-women-with-diabetes-in-comparison-with-other-long-acting-insulins
#2
Elisabeth R Mathiesen, Henning Andersen, Sofia I I Kring, Peter Damm
BACKGROUND: There are a lack of data regarding the effect of basal insulin analogues on rates of events like congenital malformation and perinatal mortality in diabetic pregnancy. METHODS: The present study is a prospective, non-interventional, multicentre cohort study conducted in seven countries, designed to assess the safety of insulin detemir during pregnancy, and to monitor the health status of resulting infants (exposed in utero) up to 1 year of age. The study population includes women with type 1 or type 2 diabetes, who are pregnant and being treated with insulin...
January 18, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27921426/-gestational-diabetes-mellitus
#3
Hana Krejčí
The present generation of women of childbearing age more frequently suffer from overweight, obesity, initial as well as fully established metabolic syndrome, which together with postponing motherhood until the third decade in life plays an important role in the increasing incidence of gestational diabetes (GDM) that currently affects about 1/5 of pregnant women. However the causal link between diabetes during pregnancy and metabolic diseases in the whole population is mutual. By way of epigenetic changes, maternal diabetes unfavourably programmes metabolism of the offspring, who tend to transfer the disorder to the next generations...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27796906/basal-bolus-therapy-in-patients-with-type-2-diabetes-mellitus-in-the-uk-patient-characteristics-treatment-patterns-and-the-effect-of-switching-to-premixed-insulin
#4
Kate van Brunt, Bradley Curtis, Tibor Ivanyi, Elemer Balogh, Corina Chalkiadaki, Sharon MacLachlan, David Neasham, Mireia Raluy-Callado
INTRODUCTION: Increasing emphasis is being placed on insulin use among patients with type 2 diabetes mellitus (T2DM). Basal-bolus (BB) therapy is regarded as the gold standard, but a high frequency of injections and the general complexity of this therapy are seen as barriers in real-world practice. Here we describe the characteristics and treatment patterns of patients with T2DM receiving BB in the UK, with specific focus on those switching to a simplified regimen of premixed insulin...
December 2016: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/27605877/metabolic-complications-in-liver-transplant-recipients
#5
REVIEW
Miguel Jiménez-Pérez, Rocío González-Grande, Edith Omonte Guzmán, Víctor Amo Trillo, Juan Miguel Rodrigo López
The metabolic syndrome (MS), which includes obesity, dyslipidaemia, hypertension and hyperglycaemia according to the most widely accepted definitions now used, is one of the most common post-transplant complications, with a prevalence of 44%-58%. The MS, together with the immunosuppression, is considered the main risk factor for the development of cardiovascular disease (CVD) in transplant recipients, which in turn accounts for 19%-42% of all deaths unrelated to the graft. The presence of MS represents a relative risk for the development of CVD and death of 1...
July 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27478438/the-effect-of-metformin-on-adolescents-with-type-1-diabetes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#6
Wei Liu, Xiao-Jie Yang
Background. The effect of metformin in combination with insulin in adolescents with type 1 diabetes (T1DM) is controversial. Methods and Results. The PubMed and EMBASE online databases were searched. Five double-blind randomized controlled trials (RCTs) that included 301 adolescents with T1DM were identified. Metformin plus insulin was associated with reduced hemoglobin A1C levels, total daily insulin dosage, body mass index (BMI), and body weight. However, the subgroup analysis demonstrated that HbA1c levels were not significantly changed in overweight/obese adolescents and were significantly reduced in the general patients...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27422504/could-intermittent-energy-restriction-and-intermittent-fasting-reduce-rates-of-cancer-in-obese-overweight-and-normal-weight-subjects-a-summary-of-evidence
#7
REVIEW
Michelle N Harvie, Tony Howell
Animal studies and human observational data link energy restriction (ER) to reduced rates of carcinogenesis. Most of these studies have involved continuous energy restriction (CER), but there is increasing public and scientific interest in the potential health and anticancer effects of intermittent energy restriction (IER) or intermittent fasting (IF), which comprise periods of marked ER or total fasting interspersed with periods of normal eating. This review summarizes animal studies that assessed tumor rates with IER and IF compared with CER or ad libitum feed consumption...
July 2016: Advances in Nutrition
https://www.readbyqxmd.com/read/27398228/the-evolving-role-of-bariatric-surgery-in-patients-with-type-1-diabetes-and-obesity
#8
Ali A Rizvi
Bariatric surgery has emerged as a viable treatment option in morbidly obese individuals with type 2 diabetes. Concomitant with societal lifestyle changes and the increased emphasis on achieving metabolic targets, there has been a rise in the number of patients with type 1 diabetes (T1DM) who are overweight and obese. Preliminary experience based on a limited number of observational reports points to substantial weight loss and amelioration of comorbid conditions such as blood pressure and dyslipidemia in patients with T1DM who undergo weight loss surgery...
2016: Integrative Obesity and Diabetes
https://www.readbyqxmd.com/read/27108152/diabetes-care-in-malaysia-problems-new-models-and-solutions
#9
REVIEW
Zanariah Hussein, Sri Wahyu Taher, Harvinder Kaur Gilcharan Singh, Winnie Chee Siew Swee
BACKGROUND: Diabetes is a major public health concern in Malaysia, and the prevalence of type 2 diabetes (T2D) has escalated to 20.8% in adults above the age of 30, affecting 2.8 million individuals. The burden of managing diabetes falls on primary and tertiary health care providers operating in various settings. OBJECTIVES: This review focuses on the current status of diabetes in Malaysia, including epidemiology, complications, lifestyle, and pharmacologic treatments, as well as the use of technologies in its management and the adoption of the World Health Organization chronic care model in primary care clinics...
November 2015: Annals of Global Health
https://www.readbyqxmd.com/read/26886777/obese-patients-with-type-2-diabetes-on-conventional-versus-intensive-insulin-therapy-efficacy-of-low-calorie-dietary-intervention
#10
Dimitrios Baltzis, Maria G Grammatikopoulou, Nikolaos Papanas, Christina-Maria Trakatelli, Evangelia Kintiraki, Maria N Hassapidou, Christos Manes
INTRODUCTION: The aim of this prospective study was to assess the results of a standard low-calorie dietary intervention (7.5 MJ/day) on body weight (BW) and the metabolic profile of obese patients with type 2 diabetes mellitus (T2DM) on intensive insulin therapy (IIT: 4 insulin injections/day) versus conventional insulin therapy (CIT: 2/3 insulin injections/day). METHODS: A total of 60 patients (n = 60, 23 males and 37 postmenopausal females) were recruited and categorized into two groups according to the scheme of insulin treatment...
March 2016: Advances in Therapy
https://www.readbyqxmd.com/read/26850040/feasibility-outcomes-of-a-presurgical-randomized-controlled-trial-exploring-the-impact-of-caloric-restriction-and-increased-physical-activity-versus-a-wait-list-control-on-tumor-characteristics-and-circulating-biomarkers-in-men-electing-prostatectomy-for-prostate
#11
RANDOMIZED CONTROLLED TRIAL
Wendy Demark-Wahnefried, Jeffery W Nix, Gary R Hunter, Soroush Rais-Bahrami, Renee A Desmond, Balu Chacko, Casey D Morrow, Maria Azrad, Andrew D Frugé, Yuko Tsuruta, Travis Ptacek, Scott A Tully, Roanne Segal, William E Grizzle
BACKGROUND: Obesity is associated with tumor aggressiveness and disease-specific mortality for more than 15 defined malignancies, including prostate cancer. Preclinical studies suggest that weight loss from caloric restriction and increased physical activity may suppress hormonal, energy-sensing, and inflammatory factors that drive neoplastic progression; however, exact mechanisms are yet to be determined, and experiments in humans are limited. METHODS: We conducted a randomized controlled trial among 40 overweight or obese, newly-diagnosed prostate cancer patients who elected prostatectomy to explore feasibility of a presurgical weight loss intervention that promoted a weight loss of roughly one kg...
February 5, 2016: BMC Cancer
https://www.readbyqxmd.com/read/26527026/-prevention-of-shoulder-dystocia-risk-factors-before-delivery
#12
REVIEW
F Fuchs
OBJECTIVE: To determine whether it is possible to prevent the occurrence of risk factors for shoulder dystocia before or during pregnancy. METHODS: The PubMed database, the Cochrane Library and the recommendations from the French and foreign obstetrical societies or colleges have been consulted. Studied measures were exercise before or during pregnancy, dietary management, and gestational diabetes management in obese and non-obese patients. RESULTS: No study has proven that the correction of these risk factors (except gestational diabetes) would reduce the risk of shoulder dystocia...
December 2015: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/26489667/effects-of-low-glycaemic-index-low-glycaemic-load-vs-high-glycaemic-index-high-glycaemic-load-diets-on-overweight-obesity-and-associated-risk-factors-in-children-and-adolescents-a-systematic-review-and-meta-analysis
#13
REVIEW
Lukas Schwingshackl, Lisa Patricia Hobl, Georg Hoffmann
The objective of the present systematic review and meta-analysis was to synthesize the available literature data investigating the effects of low glycaemic index/low glycamic load dietary regimens on anthropometric parameters, blood lipid profiles, and indicators of glucose metabolism in children and adolescents. Literature search was performed using the electronic databases MEDLINE, EMBASE, and the Cochrane Central Register of trials with restrictions to randomized controlled trials, but no limitations concerning language and publication date...
2015: Nutrition Journal
https://www.readbyqxmd.com/read/26367281/a-randomized-double-blind-placebo-controlled-trial-of-adjunctive-metformin-therapy-in-overweight-obese-youth-with-type-1-diabetes
#14
RANDOMIZED CONTROLLED TRIAL
Benjamin Udoka Nwosu, Louise Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy McShea, Bruce A Barton, Mary M Lee
CONTEXT: Insulin resistance has been proposed as one of the causes of poor glycemic control in overweight/obese youth with type 1 diabetes (T1D). However, the role of adjunctive metformin, an insulin sensitizer, on glycemic control in these patients is unclear. OBJECTIVE: To compare the effect of metformin vs. placebo on hemoglobin A1c (HbA1c), total daily dose (TDD) of insulin, and other parameters in overweight/obese youth with T1D. HYPOTHESIS: Adjunctive metformin therapy will improve glycemic control in overweight/obese youth with T1D...
2015: PloS One
https://www.readbyqxmd.com/read/26361494/low-breastfeeding-rates-and-body-mass-index-in-danish-children-of-women-with-gestational-diabetes-mellitus
#15
Jesper Fenger-Grøn, Morten Fenger-Grøn, Charlotte Holst Blunck, Helena Schønemann-Rigel, Hanne Benedicte Wielandt
BACKGROUND: Offspring from women with gestational diabetes mellitus (GDM) are at risk for later overweight, and the aim of treatment regimens is to normalize their prognosis. While the general concept is that breastfeeding is protective and should be promoted, some studies report increased levels of insulin and glucose in breast milk of women with diabetes, possibly increasing risks to the children. Previous studies may have low retention rates or mix GDM and pre-GDM, and often knowledge of confounders like maternal body mass index (BMI), level of hyperglycemia and feeding patterns is lacking...
2015: International Breastfeeding Journal
https://www.readbyqxmd.com/read/25995647/health-related-quality-of-life-in-type-1-and-type-2-diabetic-patients-in-a-portuguese-central-public-hospital
#16
Eduardo Sepúlveda, Rui Poínhos, Miguel Constante, José Pais-Ribeiro, Paula Freitas, Davide Carvalho
BACKGROUND: Diabetes mellitus is a chronic metabolic disease, the prevalence of which has registered a considerable increase, mainly in adults and elderly. The purpose of this study was to assess the relationship between health-related quality of life in patients with diabetes and sex, body mass index, type of diabetes and treatment regimens (type 1 diabetes: intensive versus conventional treatment; type 2 diabetes: insulin use versus non-insulin use), and duration of diabetes. METHODS: One hundred and twenty-four patients with diabetes were interviewed...
2015: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/25302575/potatoes-glycemic-index-and-weight-loss-in-free-living-individuals-practical-implications
#17
RANDOMIZED CONTROLLED TRIAL
Jody M Randolph, Indika Edirisinghe, Amber M Masoni, Tissa Kappagoda, Britt Burton-Freeman
BACKGROUND: The role of glycemic index (GI) and foods with negative attributes related to GI as part of a weight loss regimen has not been thoroughly assessed in free-living individuals. This study examined the effects of a dietary prescription for energy intake modification, GI, and potato consumption on weight loss, dietary prescription adherence, body composition, and glucose control in a free-living, self-selecting overweight population. METHODS: Ninety overweight (body mass index [BMI] 29...
2014: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/25246885/the-role-of-educational-level-in-glycemic-control-among-patients-with-type-ii-diabetes-mellitus
#18
Ahmad Ali S Al-Rasheedi
OBJECTIVES: To evaluate the impact of the educational level on glycemic control among patients with type II diabetes mellitus. METHODS: A disproportional systematic stratified sample of 384 patients, based on educational level, was selected from patients of type II diabetes attending the Primary Care Clinic of King Khalid University Hospital, over a period of 6 months in 2012-2013. A questionnaire sought information about socio-demographic factors, clinical characteristics, awareness of diabetic complications and self-care management behaviors...
April 2014: International Journal of Health Sciences
https://www.readbyqxmd.com/read/25194963/a-meal-replacement-regimen-improves-blood-glucose-levels-in-prediabetic-healthy-individuals-with-impaired-fasting-glucose
#19
RANDOMIZED CONTROLLED TRIAL
Daniel König, Sadaf Kookhan, Denise Schaffner, Peter Deibert, Aloys Berg
OBJECTIVE: The aim of this study was to investigate the effect of a 6-wk intervention with either lifestyle intervention (increased physical activity and a low-calorie diet) or a meal replacement regimen on glycemic control in patients who are prediabetic and have impaired fasting glucose. METHODS: Forty-two overweight or obese men and women (age 54 ± 8 y; weight 95.1 ± 11.9 kg; body mass index [BMI] 32.8 ± 2.89 kg/m(2)) were included in this randomized controlled clinical trial...
November 2014: Nutrition
https://www.readbyqxmd.com/read/25152713/high-fat-diet-induced-weight-gain-ameliorates-bone-loss-without-exacerbating-a%C3%AE-pp-processing-and-cognition-in-female-app-ps1-mice
#20
Yunhua Peng, Jing Liu, Ying Tang, Jianshu Liu, Tingting Han, Shujun Han, Hua Li, Chen Hou, Jiankang Liu, Jiangang Long
Osteoporosis is negatively correlated with body mass, whereas both osteoporosis and weight loss occur at higher incidence during the progression of Alzheimer's disease (AD) than the age-matched non-dementia individuals. Given that there is no evidence that being overweight is associated with AD-type cognitive dysfunction, we hypothesized that moderate weight gain might have a protective effect on the bone loss in AD without exacerbating cognitive dysfunction. In this study, feeding a high-fat diet (HFD, 45% calorie from fat) to female APP/PS1 transgenic mice, an AD animal model, induced weight gain...
2014: Frontiers in Cellular Neuroscience
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