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insulin regimen overweight

Miguel Jiménez-Pérez, Rocío González-Grande, Edith Omonte Guzmán, Víctor Amo Trillo, Juan Miguel Rodrigo López
The metabolic syndrome (MS), which includes obesity, dyslipidaemia, hypertension and hyperglycaemia according to the most widely accepted definitions now used, is one of the most common post-transplant complications, with a prevalence of 44%-58%. The MS, together with the immunosuppression, is considered the main risk factor for the development of cardiovascular disease (CVD) in transplant recipients, which in turn accounts for 19%-42% of all deaths unrelated to the graft. The presence of MS represents a relative risk for the development of CVD and death of 1...
July 28, 2016: World Journal of Gastroenterology: WJG
Wei Liu, Xiao-Jie Yang
Background. The effect of metformin in combination with insulin in adolescents with type 1 diabetes (T1DM) is controversial. Methods and Results. The PubMed and EMBASE online databases were searched. Five double-blind randomized controlled trials (RCTs) that included 301 adolescents with T1DM were identified. Metformin plus insulin was associated with reduced hemoglobin A1C levels, total daily insulin dosage, body mass index (BMI), and body weight. However, the subgroup analysis demonstrated that HbA1c levels were not significantly changed in overweight/obese adolescents and were significantly reduced in the general patients...
2016: International Journal of Endocrinology
Michelle N Harvie, Tony Howell
Animal studies and human observational data link energy restriction (ER) to reduced rates of carcinogenesis. Most of these studies have involved continuous energy restriction (CER), but there is increasing public and scientific interest in the potential health and anticancer effects of intermittent energy restriction (IER) or intermittent fasting (IF), which comprise periods of marked ER or total fasting interspersed with periods of normal eating. This review summarizes animal studies that assessed tumor rates with IER and IF compared with CER or ad libitum feed consumption...
July 2016: Advances in Nutrition
Ali A Rizvi
Bariatric surgery has emerged as a viable treatment option in morbidly obese individuals with type 2 diabetes. Concomitant with societal lifestyle changes and the increased emphasis on achieving metabolic targets, there has been a rise in the number of patients with type 1 diabetes (T1DM) who are overweight and obese. Preliminary experience based on a limited number of observational reports points to substantial weight loss and amelioration of comorbid conditions such as blood pressure and dyslipidemia in patients with T1DM who undergo weight loss surgery...
2016: Integrative Obesity and Diabetes
Zanariah Hussein, Sri Wahyu Taher, Harvinder Kaur Gilcharan Singh, Winnie Chee Siew Swee
BACKGROUND: Diabetes is a major public health concern in Malaysia, and the prevalence of type 2 diabetes (T2D) has escalated to 20.8% in adults above the age of 30, affecting 2.8 million individuals. The burden of managing diabetes falls on primary and tertiary health care providers operating in various settings. OBJECTIVES: This review focuses on the current status of diabetes in Malaysia, including epidemiology, complications, lifestyle, and pharmacologic treatments, as well as the use of technologies in its management and the adoption of the World Health Organization chronic care model in primary care clinics...
November 2015: Annals of Global Health
Dimitrios Baltzis, Maria G Grammatikopoulou, Nikolaos Papanas, Christina-Maria Trakatelli, Evangelia Kintiraki, Maria N Hassapidou, Christos Manes
INTRODUCTION: The aim of this prospective study was to assess the results of a standard low-calorie dietary intervention (7.5 MJ/day) on body weight (BW) and the metabolic profile of obese patients with type 2 diabetes mellitus (T2DM) on intensive insulin therapy (IIT: 4 insulin injections/day) versus conventional insulin therapy (CIT: 2/3 insulin injections/day). METHODS: A total of 60 patients (n = 60, 23 males and 37 postmenopausal females) were recruited and categorized into two groups according to the scheme of insulin treatment...
March 2016: Advances in Therapy
Wendy Demark-Wahnefried, Jeffery W Nix, Gary R Hunter, Soroush Rais-Bahrami, Renee A Desmond, Balu Chacko, Casey D Morrow, Maria Azrad, Andrew D Frugé, Yuko Tsuruta, Travis Ptacek, Scott A Tully, Roanne Segal, William E Grizzle
BACKGROUND: Obesity is associated with tumor aggressiveness and disease-specific mortality for more than 15 defined malignancies, including prostate cancer. Preclinical studies suggest that weight loss from caloric restriction and increased physical activity may suppress hormonal, energy-sensing, and inflammatory factors that drive neoplastic progression; however, exact mechanisms are yet to be determined, and experiments in humans are limited. METHODS: We conducted a randomized controlled trial among 40 overweight or obese, newly-diagnosed prostate cancer patients who elected prostatectomy to explore feasibility of a presurgical weight loss intervention that promoted a weight loss of roughly one kg...
2015: BMC Cancer
F Fuchs
OBJECTIVE: To determine whether it is possible to prevent the occurrence of risk factors for shoulder dystocia before or during pregnancy. METHODS: The PubMed database, the Cochrane Library and the recommendations from the French and foreign obstetrical societies or colleges have been consulted. Studied measures were exercise before or during pregnancy, dietary management, and gestational diabetes management in obese and non-obese patients. RESULTS: No study has proven that the correction of these risk factors (except gestational diabetes) would reduce the risk of shoulder dystocia...
December 2015: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
Lukas Schwingshackl, Lisa Patricia Hobl, Georg Hoffmann
The objective of the present systematic review and meta-analysis was to synthesize the available literature data investigating the effects of low glycaemic index/low glycamic load dietary regimens on anthropometric parameters, blood lipid profiles, and indicators of glucose metabolism in children and adolescents. Literature search was performed using the electronic databases MEDLINE, EMBASE, and the Cochrane Central Register of trials with restrictions to randomized controlled trials, but no limitations concerning language and publication date...
2015: Nutrition Journal
Benjamin Udoka Nwosu, Louise Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy McShea, Bruce A Barton, Mary M Lee
CONTEXT: Insulin resistance has been proposed as one of the causes of poor glycemic control in overweight/obese youth with type 1 diabetes (T1D). However, the role of adjunctive metformin, an insulin sensitizer, on glycemic control in these patients is unclear. OBJECTIVE: To compare the effect of metformin vs. placebo on hemoglobin A1c (HbA1c), total daily dose (TDD) of insulin, and other parameters in overweight/obese youth with T1D. HYPOTHESIS: Adjunctive metformin therapy will improve glycemic control in overweight/obese youth with T1D...
2015: PloS One
Jesper Fenger-Grøn, Morten Fenger-Grøn, Charlotte Holst Blunck, Helena Schønemann-Rigel, Hanne Benedicte Wielandt
BACKGROUND: Offspring from women with gestational diabetes mellitus (GDM) are at risk for later overweight, and the aim of treatment regimens is to normalize their prognosis. While the general concept is that breastfeeding is protective and should be promoted, some studies report increased levels of insulin and glucose in breast milk of women with diabetes, possibly increasing risks to the children. Previous studies may have low retention rates or mix GDM and pre-GDM, and often knowledge of confounders like maternal body mass index (BMI), level of hyperglycemia and feeding patterns is lacking...
2015: International Breastfeeding Journal
Eduardo Sepúlveda, Rui Poínhos, Miguel Constante, José Pais-Ribeiro, Paula Freitas, Davide Carvalho
BACKGROUND: Diabetes mellitus is a chronic metabolic disease, the prevalence of which has registered a considerable increase, mainly in adults and elderly. The purpose of this study was to assess the relationship between health-related quality of life in patients with diabetes and sex, body mass index, type of diabetes and treatment regimens (type 1 diabetes: intensive versus conventional treatment; type 2 diabetes: insulin use versus non-insulin use), and duration of diabetes. METHODS: One hundred and twenty-four patients with diabetes were interviewed...
2015: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Jody M Randolph, Indika Edirisinghe, Amber M Masoni, Tissa Kappagoda, Britt Burton-Freeman
BACKGROUND: The role of glycemic index (GI) and foods with negative attributes related to GI as part of a weight loss regimen has not been thoroughly assessed in free-living individuals. This study examined the effects of a dietary prescription for energy intake modification, GI, and potato consumption on weight loss, dietary prescription adherence, body composition, and glucose control in a free-living, self-selecting overweight population. METHODS: Ninety overweight (body mass index [BMI] 29...
2014: Journal of the American College of Nutrition
Ahmad Ali S Al-Rasheedi
OBJECTIVES: To evaluate the impact of the educational level on glycemic control among patients with type II diabetes mellitus. METHODS: A disproportional systematic stratified sample of 384 patients, based on educational level, was selected from patients of type II diabetes attending the Primary Care Clinic of King Khalid University Hospital, over a period of 6 months in 2012-2013. A questionnaire sought information about socio-demographic factors, clinical characteristics, awareness of diabetic complications and self-care management behaviors...
April 2014: International Journal of Health Sciences
Daniel König, Sadaf Kookhan, Denise Schaffner, Peter Deibert, Aloys Berg
OBJECTIVE: The aim of this study was to investigate the effect of a 6-wk intervention with either lifestyle intervention (increased physical activity and a low-calorie diet) or a meal replacement regimen on glycemic control in patients who are prediabetic and have impaired fasting glucose. METHODS: Forty-two overweight or obese men and women (age 54 ± 8 y; weight 95.1 ± 11.9 kg; body mass index [BMI] 32.8 ± 2.89 kg/m(2)) were included in this randomized controlled clinical trial...
November 2014: Nutrition
Yunhua Peng, Jing Liu, Ying Tang, Jianshu Liu, Tingting Han, Shujun Han, Hua Li, Chen Hou, Jiankang Liu, Jiangang Long
Osteoporosis is negatively correlated with body mass, whereas both osteoporosis and weight loss occur at higher incidence during the progression of Alzheimer's disease (AD) than the age-matched non-dementia individuals. Given that there is no evidence that being overweight is associated with AD-type cognitive dysfunction, we hypothesized that moderate weight gain might have a protective effect on the bone loss in AD without exacerbating cognitive dysfunction. In this study, feeding a high-fat diet (HFD, 45% calorie from fat) to female APP/PS1 transgenic mice, an AD animal model, induced weight gain...
2014: Frontiers in Cellular Neuroscience
Adrienne R Barnosky, Kristin K Hoddy, Terry G Unterman, Krista A Varady
Intermittent fasting (IF) regimens have gained considerable popularity in recent years, as some people find these diets easier to follow than traditional calorie restriction (CR) approaches. IF involves restricting energy intake on 1-3 d/wk, and eating freely on the nonrestriction days. Alternate day fasting (ADF) is a subclass of IF, which consists of a "fast day" (75% energy restriction) alternating with a "feed day" (ad libitum food consumption). Recent findings suggest that IF and ADF are equally as effective as CR for weight loss and cardioprotection...
October 2014: Translational Research: the Journal of Laboratory and Clinical Medicine
Marilia Brito Gomes, Carlos Antonio Negrato, Roberta Cobas, Lucianne Righeti Monteiro Tannus, Paolla Ribeiro Gonçalves, Pedro Carlos Barreto da Silva, João Regis Ivar Carneiro, Alessandra Saldanha Mattos Matheus, Sergio Atala Dib, Mirela Jobim Azevedo, Márcia Nery, Melanie Rodacki, Lenita Zajdenverg, Renan Magalhães Montenegro Junior, Janice Sepulveda, Luis Eduardo Calliari, Deborah Jezini, Neuza Braga, Jorge L Luescher, Renata S Berardo, Maria Carmo Arruda-Marques, Renata M Noronha, Thais D Manna, Roberta Salvodelli, Fernanda G Penha, Milton C Foss, Maria C Foss-Freitas, Antonio C Pires, Fernando C Robles, Maria de Fátima S Guedes, Patricia Dualib, Saulo C Silva, Emerson Sampaio, Rosangela Rea, Ana Cristina R Faria, Balduino Tschiedel, Suzana Lavigne, Luis Henrique Canani, Alessandra T Zucatti, Marisa Helena C Coral, Daniela Aline Pereira, Luiz Antonio Araujo, Monica Tolentino, Hermelinda C Pedrosa, Flaviane A Prado, Nelson Rassi, Leticia B Araujo, Reine Marie C Fonseca, Alexis D Guedes, Odelissa S Matos, Catia C Palma, Rossana Azulay, Adriana C Forti, Cristina Façanha, Ana Paula Montenegro, Naira H Melo, Karla F Rezende, Alberto Ramos, João Soares Felicio, Flavia M Santos
BACKGROUND: To evaluate the determinants of intensive insulin regimens (ITs) in patients with type 1 diabetes (T1D). METHODS: This multicenter study was conducted between December 2008 and December 2010 in 28 public clinics in 20 Brazilian cities. Data were obtained from 3,591 patients (56.0% female, 57.1% Caucasian). Insulin regimens were classified as follows: group 1, conventional therapy (CT) (intermediate human insulin, one to two injections daily); group 2 (three or more insulin injections of intermediate plus regular human insulin); group 3 (three or more insulin injections of intermediate human insulin plus short-acting insulin analogues); group 4, basal-bolus (one or two insulin injections of long-acting plus short-acting insulin analogues or regular insulin); and group 5, basal-bolus with continuous subcutaneous insulin infusion (CSII)...
2014: Diabetology & Metabolic Syndrome
S Del Prato, J E Foley, W Kothny, P Kozlovski, M Stumvoll, P M Paldánius, D R Matthews
AIMS: Durability of good glycaemic control (HbA1c ) is of importance as it can be the foundation for delaying diabetic complications. It has been hypothesized that early initiation of treatment with the combination of oral anti-diabetes agents with complementary mechanisms of action can increase the durability of glycaemic control compared with metformin monotherapy followed by a stepwise addition of oral agents. Dipeptidyl peptidase-4 inhibitors are good candidates for early use as they are efficacious in combination with metformin, show weight neutrality and a low risk of hypoglycaemia...
October 2014: Diabetic Medicine: a Journal of the British Diabetic Association
Bilal A Omar, Giovanni Pacini, Bo Ahrén
Insulin sensitivity declines in overweight and obese individuals and, under normal conditions, insulin secretion adaptively increases which in healthy non-diabetic subjects maintains normal glycemia. This adaptation is best described by the disposition index derived from modeling of insulin and glucose data from an intravenous glucose tolerance testing (IVGTT). One caveat of the IVGTT is that basing the glucose dose on the individual total body weight can result in large differences in the amount of glucose given to lean and obese individuals...
May 1, 2014: Physiological Reports
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