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https://www.readbyqxmd.com/read/27802299/protective-effects-of-essential-oils-as-natural-antioxidants-against-hepatotoxicity-induced-by-cyclophosphamide-in-mice
#1
Salah A Sheweita, Lobna S El-Hosseiny, Munther A Nashashibi
Clinical application of cyclophosphamide (CP) as an anticancer drug is often limited due to its toxicity. CP is metabolized mainly in the liver by cytochrome P450 system into acrolein which is the proximate toxic metabolite. Many different natural antioxidants were found to alleviate the toxic effects of various toxic agents via different mechanisms. Therefore, the present study aimed at investigating the role of essential oils extracted from fennel, cumin and clove as natural antioxidants in the alleviation of hepatotoxicity induced by CP through assessment of hepatotoxicity biomarkers (AST, ALT, ALP), histopathology of liver tissues as well as other biochemical parameters involved in the metabolism of CP...
2016: PloS One
https://www.readbyqxmd.com/read/27800121/erectile-dysfunction-drugs-changed-the-protein-expressions-and-activities-of-drug-metabolising-enzymes-in-the-liver-of-male-rats
#2
Salah A Sheweita, Mona Wally, Mostafa Hassan
Erectile dysfunction (ED) is a major health problem and is mainly associated with the persistent inability of men to maintain sufficient erection for satisfactory sexual performance. Millions of men are using sildenafil, vardenafil, and/or tadalafil for ED treatment. Cytochrome P450s (CYPs) play a central role in the metabolism of a wide range of xenobiotics as well as endogenous compounds. Susceptibility of individuals to the adverse effects of different drugs is mainly dependent on the expression of CYPs proteins...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27637481/a-comparison-of-the-genotoxicity-of-benzo-a-pyrene-in-four-cell-lines-with-differing-metabolic-capacity
#3
Ume-Kulsoom Shah, Anna L Seager, Paul Fowler, Shareen H Doak, George E Johnson, Sharon J Scott, Andrew D Scott, Gareth J S Jenkins
Benzo[a]pyrene (B[a]P) is a known genotoxin and carcinogen, yet its genotoxic response at low level exposure has not been determined. This study was conducted to examine the interplay of dose and metabolic capacity on genotoxicity of B[a]P. Investigating and better understanding the biological significance of low level chemical exposures will help improve human health risk assessments. The genotoxic and mutagenic effects of B[a]P were investigated using human cell lines (AHH-1, MCL-5, TK6 and HepG2) with differential expression of the CYP450 enzymes CYP1A1, 1B1 and1A2 involved in B[a]P metabolism...
September 15, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27477798/fluorescence-versus-x-ray-cholangiography-during-laparoscopic-cholecystectomy-protocol-for-a-randomised-trial
#4
Lars Lang Lehrskov, Søren S Larsen, Billy B Kristensen, Thue Bisgaard
INTRODUCTION: Intraoperative fluorescent cholangiography is a novel non-invasive imaging technique to visualise the extrahepatic biliary tract during laparoscopic cholecystectomy. It has been proven feasible, fast and cost effective. Never-theless, there is only sparse data on the capacity of fluorescent cholangiography to visualise the biliary anatomy. METHODS: Based on a non-inferiority design, patients with complicated gallstone disease are randomised to either -intraoperative conventional X-ray cholangiography (reference group, n = 60) or intraoperative fluorescent cholangiography (n = 60)...
August 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27429710/radioprotective-effect-of-grape-seed-proanthocyanidins-in-vitro-and-in-vivo
#5
Yijuan Huang, Hainan Zhao, Kun Cao, Ding Sun, Yanyong Yang, Cong Liu, Jianguo Cui, Ying Cheng, Bailong Li, Jianming Cai, Fu Gao
We have demonstrated that grape seed proanthocyanidins (GSPs) could effectively scavenge hydroxyl radical (•OH) in a dose-dependent manner. Since most of the ionizing radiation- (IR-) induced injuries were caused by •OH, this study was to investigate whether GSPs would mitigate IR-induced injuries in vitro and in vivo. We demonstrated that GSPs could significantly reduce IR-induced DNA strand breaks (DSBs) and apoptosis of human lymphocyte AHH-1 cells. This study also showed that GSPs could protect white blood cells (WBC) from IR-induced injuries, speed up the weight of mice back, and decrease plasma malondialdehyde (MDA), thus improving the survival rates of mice after ionizing radiation...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27272250/buffalo-bubalus-bubali-late-embryo-and-foetus-development-a-morphological-analysis
#6
A C Morini, Ncg Pieri, Kcs Roballo, D S Martins, C E Ambrósio, J C Morini Junior, P O Favaron, Ahh Minervino, Fvt Pereira, M A Miglino
Many researches describe the embryonic developmental features in domestic animals; however, in farm animals, they are scarce. Most farm animal studies are related to assisted reproduction and embryos transfer techniques. But, morphological features and size measure to estimate the age gestation are rarely reported in literature. Thus, in this study, we described the developmental changes in the bubaline (Bubalus bubali) concepts from 21 to 60 days of gestation. Our results revealed that buffalo embryos similar morphological characteristics similar to other mammalian species...
August 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27231887/ethanolic-extract-of-acanthopanax-koreanum-nakai-alleviates-alcoholic-liver-damage-combined-with-a-high-fat-diet-in-c57bl-6j-mice
#7
Haein Kim, Minyoung Park, Jae-Ho Shin, Oran Kwon
Alcoholic and nonalcoholic liver steatosis have an indistinguishable spectrum of histological features and liver enzyme elevations. In this study, we investigated the potential of the ethanolic extract of Acanthopanax koreanum Nakai (AK) to protect against experimental alcoholic liver disease in a mouse model that couples diet and daily ethanol bolus gavage. Fifty-six C57BL/6J mice were randomly divided into seven groups: normal control (NC), alcohol control (AC), alcohol/HFD control (AH), low-dose (1%) AK in alcohol group (ACL), high-dose (3%) AK in alcohol group (ACH), low-dose AK in alcohol/HFD group (AHL), and high-dose AK in alcohol/HFD group (AHH)...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27131750/toxic-effects-upon-exposure-to-polycyclic-aromatic-hydrocarbon-chrysene-in-scallop-chlamys-farreri-during-the-reproduction-period
#8
Meng Xiu, Luqing Pan, Qian Jin
This study aims to investigate potential toxic effects of chrysene (CHR) on mature scallop Chlamys farreri during the reproduction period, using indicators of antioxidant defences and oxidative stress. Scallops were exposed to 0.2, 0.8 and 3.2μg/L waterborne CHR for 21 days, at day 10 scallops were induced to spawn. At days 1, 3, 6, 10, 11, 15 and 21, aryl hydrocarbon hydroxylase (AHH), 7-ethoxyresorufin-O-deethylase (EROD), glutathione-s-transferase (GST), glutathione (GSH), superoxide dismutase (SOD), lipid peroxidation (LPO), protein carbonyl (PC) and DNA strand breaks in digestive glands were examined by separately analysing male and female scallops...
June 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27112800/-acute-liver-ischaemia-after-gastro-oesophageal-variceal-bleeding
#9
Carla Senosiain Lalastra, Julia Arribas Anta, Víctor Moreira Vicente, Javier Martínez González, Maite Maroto Castellanos, María Concepción García Sánchez, Celia Zaera de la Fuente, Sergio López Durán, Ángel Cañete Ruiz, Agustín Albillos Martínez
INTRODUCTION: Variceal upper gastrointestinal bleeding (UGIB) can trigger acute hypoxic hepatitis (AHH). The aim of this study was to analyse the incidence, associated risk factors and mortality of AHH after variceal UGIB. PATIENTS AND METHODS: Retrospective study of cirrhotic patients with variceal UGIB, classified into 2 groups according to the development of AHH. AHH was diagnosed when AST and ALT reached levels 10 times above the upper limit of normal, after ruling out other causes of hepatitis...
November 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27104493/populations-of-some-molds-in-water-damaged-homes-may-differ-if-the-home-was-constructed-with-gypsum-drywall-compared-to-plaster
#10
Stephen Vesper, Larry Wymer, David Cox, Gary Dewalt
Starting in the 1940s, gypsum drywall began replacing plaster and lathe in the U.S. home construction industry. Our goal was to evaluate whether some mold populations differ in water- damaged homes primarily constructed with gypsum drywall compared to plaster. The dust samples from the 2006 Department of Housing and Urban Development's (HUD) American Health Homes Survey (AHHS) were the subject of this analysis. The concentrations of the 36 Environmental Relative Moldiness Index (ERMI) molds were compared in homes of different ages...
August 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27026082/alcoholic-hepatitis-histological-score-has-high-accuracy-to-predict-90-day-mortality-and-response-to-steroids
#11
Patrícia Andrade, Marco Silva, Susana Rodrigues, Joanne Lopes, Susana Lopes, Guilherme Macedo
INTRODUCTION/OBJECTIVES: A histological classification system (AHHS) has been recently proposed to predict 90-day mortality in patients with alcoholic hepatitis (AH). We analyzed the spectrum of histological features in patients with AH and assessed the ability of AHHS for predicting both response to steroids and 90-day mortality. METHODS: Retrospective study of patients admitted to our tertiary centre between 2010 and 2014 with biopsy-proven AH. Histological features were analyzed and AHHS value was calculated...
June 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/26812473/linking-high-resolution-mass-spectrometry-data-with-exposure-and-toxicity-forecasts-to-advance-high-throughput-environmental-monitoring
#12
Julia E Rager, Mark J Strynar, Shuang Liang, Rebecca L McMahen, Ann M Richard, Christopher M Grulke, John F Wambaugh, Kristin K Isaacs, Richard Judson, Antony J Williams, Jon R Sobus
There is a growing need in the field of exposure science for monitoring methods that rapidly screen environmental media for suspect contaminants. Measurement and analysis platforms, based on high resolution mass spectrometry (HRMS), now exist to meet this need. Here we describe results of a study that links HRMS data with exposure predictions from the U.S. EPA's ExpoCast™ program and in vitro bioassay data from the U.S. interagency Tox21 consortium. Vacuum dust samples were collected from 56 households across the U...
March 2016: Environment International
https://www.readbyqxmd.com/read/26770575/comparison-between-nitroglycerin-and-remifentanil-in-acute-hypervolemic-hemodilution-combined-with-controlled-hypotension-during-intracranial-aneurysm-surgery
#13
Xuekang Zhang, Qian Hu, Zhiyi Liu, Haijin Huang, Qin Zhang, Hanying Dai
Allogenetic transfusion has long been considered to be a relatively safe and extremely effective blood transfusion treatment. However, acute hypervolemic hemodilution (AHH) combined with the remifentanil-induced controlled hypotension (CH) have rarely been examined. Herein, 40 intracranial aneurysm surgery patients were randomly divided into nitroglycerin group (A group, n=20) and remifentanil group (B group, n=20). During intracranial aneurysm surgery, MAP, HR, Hb, and Hct were recorded. SjvO2, PjvO2, SaO2, PaO2 were measured, and CaO2, Da-jvO2, CjvO2, CERO2, VADL were calculated...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26740862/acquired-hypogonadotropic-hypogonadism-ahh-in-thalassaemia-major-patients-an-underdiagnosed-condition
#14
Vincenzo De Sanctis, Heba Elsedfy, Ashraf T Soliman, Ihab Zaki Elhakim, Alessia Pepe, Christos Kattamis, Nada A Soliman, Rania Elalaily, Mohamed El Kholy, Mohamed Yassin
INTRODUCTION: In males, acquired hypogonadotropic hypogonadism (AHH) includes all disorders that damage or alter the function of gonadotropin-releasing hormone (GnRH) neurons and/or pituitary gonadotroph cells. The clinical characteristics of AHH are androgen deficiency and lack, delay or halt of pubertal sexual maturation. AHH lead to decreased libido, impaired erectile function, and strength, a worsened sense of well-being and degraded quality of life (QOL). PATIENTS AND METHODS: We studied 11 adult men with thalassemia major (TM) aged between 26 to 54 years (mean ± SD: 34...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/26600285/promotora-assisted-depression-care-among-predominately-hispanic-patients-with-concurrent-chronic-illness-public-care-system-clinical-trial-design
#15
RANDOMIZED CONTROLLED TRIAL
Kathleen Ell, María P Aranda, Shinyi Wu, Hyunsung Oh, Pey-Jiuan Lee, Jeffrey Guterman
Depression frequently negatively affects patient overall self-care and social stress management within United States safety net care systems. Rates of major depression are significantly high among low-income predominantly Hispanic/Latino with chronic illness, such as diabetes and heart disease. The study design of the A Helping Hand to Activate Patient-Centered Depression Care among Low-income Patients (AHH) randomized clinical trial aims to enhance patient depression care receipt and overall bio-psychosocial self-care management...
January 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/26385012/automated-tms-hotspot-hunting-using-a-closed-loop-threshold-based-algorithm
#16
Jonna Meincke, Manuel Hewitt, Giorgi Batsikadze, David Liebetanz
BACKGROUND: Although neuronavigation is increasingly used for optimizing coil positioning, the inter-session reliability of hotspot location remains unsatisfactory, probably due to the variability of motor evoked potentials (MEPs) and residual investigator bias. PURPOSE: To increase the reliability and accuracy of hotspot location we introduce a novel automated hotspot-hunting procedure (AHH). METHODS: AHH is based on resting motor thresholds (RMTs) instead of MEP amplitudes...
January 1, 2016: NeuroImage
https://www.readbyqxmd.com/read/26362870/the-clastogenicity-of-4nqo-is-cell-type-dependent-and-linked-to-cytotoxicity-length-of-exposure-and-p53-proficiency
#17
Katja Brüsehafer, Bella B Manshian, Ann T Doherty, Zoulikha M Zaïr, George E Johnson, Shareen H Doak, Gareth J S Jenkins
4-Nitroquinoline 1-oxide (4NQO) is used as a positive control in various genotoxicity assays because of its known mutagenic and carcinogenic properties. The chemical is converted into 4-hydroxyaminoquinoline 1-oxide and gives rise to three main DNA adducts, N-(deoxyguanosin-8-yl)-4AQO, 3-(desoxyguanosin-N (2)-yl)-4AQO and 3-(deoxyadenosin-N (6)-yl)-4AQO. This study was designed to assess the shape of the dose-response curve at low concentrations of 4NQO in three human lymphoblastoid cell lines, MCL-5, AHH-1 and TK6 as well as the mouse lymphoma L5178Y cell line in vitro...
March 2016: Mutagenesis
https://www.readbyqxmd.com/read/26339380/mci-extraction-from-turkish-galls-played-protective-roles-against-x-ray-induced-damage-in-ahh-1-cells
#18
Jianhua Yang, Yan Zhou, Huibin Liu, Jianhua Wang, Junping Hu
OBJECTIVE: To investigate the protective effects of MCI extract from Turkish galls against apoptosis induced by X-ray radiation in the AHH-1. METHODS: The cells were divided into: control group; X-ray radiation group; MCI group, in which the confluent cells were preincubated with 5 μg/ml MCI for 2 h followed by radiation. For the radiation, cells preincubated with MCI were exposed to X-ray beams with a dose of 8 Gy in total. Cell viability, apoptosis and intracellular alteration of redox were monitored by MTT and flow cytometry...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26198944/-effects-of-acute-hypervolemic-hemodilution-and-intraoperative-blood-salvage-on-erythrocyte-morphology-and-biomechanics
#19
Yiwen Zhang, Zumin Xinh, Qiang Guo, Zhongcheng He
OBJECTIVE: To investigate the effects of acute hypervolemic hemodilution (AHH) and intraoperative blood salvage (IOBS) on the morphology and biomechanics of erythrocytes using atomic force microscopy (AFM). METHODS: Blood samples were collected from 20 patients undergoing orthopedic surgery before operation (T1), immediately after AHH (T2), and after blood salvage (T3). AFM at nanometer resolution was used to examine the morphology and biomechanics of the collected erythrocytes...
July 2015: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/25918796/protective-activity-of-c-geranylflavonoid-analogs-from-paulownia-tomentosa-against-dna-damage-in-137cs-irradiated-ahh-1-cells
#20
Hyung-In Moon, Min Ho Jeong, Wol Soon Jo
Radiotherapy is an important form of treatment for a wide range of cancers, but it can damage DNA and cause adverse effects. We investigated if the diplacone analogs of P. tomentosa were radio-protective in a human lymphoblastoid cell line (AHH-1). Four geranylated flavonoids, diplacone, 3'-O-methyl-5'-hydroxydiplacone, 3'-O-methyl-5'-O-methyldiplacone and 3'-O-methyldiplacol, were tested for their antioxidant and radio-protective effects. Diplacone analogs effectively scavenged free radicals and inhibited radiation-induced DNA strand breaks in vitro...
September 2014: Natural Product Communications
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