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https://www.readbyqxmd.com/read/28805378/in-vitro-modulation-of-renin-angiotensin-system-enzymes-by-amaranth-amaranthus-hypochondriacus-protein-derived-peptides-alternative-mechanisms-different-from-ace-inhibition
#1
Alejandra V Quiroga, Paula Aphalo, Agustina E Nardo, María C Añón
Among the factors affecting the development of cardiovascular diseases, hypertension is one of the most important. Research done on amaranth proteins has demonstrated their hypotensive capacity in vivo and in vitro; nevertheless, the mechanism underlying this effect remains unclear. The aim of this study was to analyze in vitro the inhibition of peptides derived from an amaranth hydrolysate (AHH) on other RAS enzymes other than ACE. The chymase and renin activities were studied. AHH was not able to inhibit chymase activity, although a dose-response effect was found on renin activity (IC50 0...
August 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28763014/two-hop-adaptive-vector-based-quality-forwarding-for-void-hole-avoidance-in-underwater-wsns
#2
Nadeem Javaid, Farwa Ahmed, Zahid Wadud, Nabil Alrajeh, Mohamad Souheil Alabed, Manzoor Ilahi
Underwater wireless sensor networks (UWSNs) facilitate a wide range of aquatic applications in various domains. However, the harsh underwater environment poses challenges like low bandwidth, long propagation delay, high bit error rate, high deployment cost, irregular topological structure, etc. Node mobility and the uneven distribution of sensor nodes create void holes in UWSNs. Void hole creation has become a critical issue in UWSNs, as it severely affects the network performance. Avoiding void hole creation benefits better coverage over an area, less energy consumption in the network and high throughput...
August 1, 2017: Sensors
https://www.readbyqxmd.com/read/28684357/promotora-assisted-depression-and-self-care-management-among-predominantly-latinos-with-concurrent-chronic-illness-safety-net-care-system-clinical-trial-results
#3
Kathleen Ell, María P Aranda, Shinyi Wu, Hyunsung Oh, Pey-Jiuan Lee, Jeffrey Guterman
The study evaluated depression and self-care management among patients with diabetes and/or heart disease in a 12-month randomized trial conducted in Los Angeles County Department of Health Services (LAC-DHS) community clinics. We compared LAC-DHS clinic usual care (UC) versus A-Helping-Hand (AHH) intervention in which bilingual promotoras, hired and supervised by the research project, provided 6 weekly psychoeducational sessions followed by boosters. Of 1957 screened, 348 depressed patients (PHQ-9 score≥10) were enrolled, randomized to AHH (n=178) or UC (n=170) after baseline interview assessing mental health, treatment receipt, co-morbid illness, self-care management, and environmental stressors...
July 3, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28671202/transcriptome-dynamics-of-human-pluripotent-stem-cell-derived-contracting-cardiomyocytes-using-an-embryoid-body-model-with-fetal-bovine-serum
#4
Kwang Bo Jung, Ye Seul Son, Hana Lee, Cho-Rok Jung, Janghwan Kim, Mi-Young Son
Cardiomyocyte (CM) differentiation techniques for generating adult-like mature CMs remain imperfect, and the plausible underlying mechanisms remain unclear; however, there are a number of current protocols available. Here, to explore the mechanisms controlling cardiac differentiation, we analyzed the genome-wide transcription dynamics occurring during the differentiation of human pluripotent stem cells (hPSCs) into CMs using embryoid body (EB) formation. We optimized and updated the protocol to efficiently generate contracting CMs from hPSCs by adding fetal bovine serum (FBS) as a medium supplement, which could have a significant impact on the efficiency of cardiac differentiation...
July 25, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28654190/interobserver-variability-in-scoring-liver-biopsies-with-a-diagnosis-of-alcoholic-hepatitis
#5
Bela Horvath, Daniela Allende, Hao Xie, John Guirguis, Jennifer Jeung, James Lapinski, Deepa Patil, Arthur J McCullough, Srinivasan Dasarathy, Xiuli Liu
BACKGROUND: Alcoholic hepatitis (AH) is one of the most severe forms of alcoholic liver disease. Recently, a histologic scoring system for predicting prognosis in this patient cohort was proposed as Alcoholic Hepatitis Histologic Score (AHHS). We aimed to assess interobserver variability in recognizing histologic features of AH, and the effect of this variability on the proposed AHHS categories. DESIGN: Hematoxylin-eosin and trichrome stained slides from 32 patients diagnosed with AH with liver biopsies within 1 month of presentation (2000-2015), were reviewed by 5 pathologists including 3 liver pathologists and 2 gastrointestinal (GI) pathologists masked to the clinical findings or outcome...
June 27, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28646216/effects-of-naftopidil-on-double-j-stent-related-discomfort-a-multicenter-randomized-double-blinded-placebo-controlled-study
#6
Jong Jin Oh, Sangchul Lee, Sung Yong Cho, Sang Wook Lee, Min Chul Cho, Woong Na, Ju Hyeon Park, Seung Bae Lee, Soyeon Ahh, Chang Wook Jeong
To evaluate the effect of naftopidil 75 mg once daily for ureteral double-J (DJ) stent-related discomfort after a ureteroscopic procedure using a multicenter, randomized, double-blinded, placebo-controlled study. 100 patients with indwelled retrograde DJ ureteral stents after ureteroscopic stone removal or retrograde intrarenal surgery (RIRS) were randomized 1:1 to receive either placebo or naftopidil during the stenting period. At the time of stent removal, the Ureteral Stent Symptom Questionnaire (USSQ), the International Prostate Symptom Score and the total amount of used analgesics were reported...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28622829/investigation-of-j-shaped-dose-responses-induced-by-exposure-to-the-alkylating-agent-n-methyl-n-nitrosourea
#7
Katherine E Chapman, George R Hoffmann, Shareen H Doak, Gareth J S Jenkins
Hormesis is defined as a biphasic dose-response where biological effects of low doses of a stressor demonstrate the opposite effect to high-dose effects of the same stressor. Hormetic, or J-shaped, dose-response relationships are relatively rarely observed in toxicology, resulting in a limited understanding and even some skepticism of the concept. Low dose-response studies for genotoxicity endpoints have been performed at Swansea University for over a decade. However, no statistically significant decreases below control genotoxicity levels have been detected until recently...
July 2017: Mutation Research
https://www.readbyqxmd.com/read/28487163/a-multi-year-study-of-hepatic-biomarkers-in-coastal-fishes-from-the-gulf-of-mexico-after-the-deepwater-horizon-oil-spill
#8
Marci Smeltz, Laura Rowland-Faux, Céline Ghiran, William F Patterson, Steven B Garner, Alan Beers, Quentin Mièvre, Andrew S Kane, Margaret O James
Following the 2010 Gulf of Mexico oil spill, concerns were raised regarding exposure of fish to crude oil components, particularly polycyclic aromatic hydrocarbons (PAHs). This three year study examined hepatic enzymes in post-mitochondrial supernatant fractions from red snapper (Lutjanus campechanus) and gray triggerfish (Balistes capriscus) collected in the north central Gulf of Mexico between 2011 and 2014. Biomarker activities evaluated included benzo(a)pyrene hydroxylase (AHH), ethoxyresorufin O-deethylase (EROD), glutathione transferase (GST), and glutathione peroxidase (GPx)...
August 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28452249/6-7-3-4-tetrahydroxyisoflavone-improves-the-survival-of-whole-body-irradiated-mice-via-restoration-of-hematopoietic-function
#9
Cong Liu, Jing Liu, Yuhui Hao, Ying Gu, Zhangyou Yang, Hong Li, Rong Li
PURPOSE: 6,7,3',4'-tetrahydroxyisoflavone (T3) is a novel chemically synthesized compound reported in our previous study. This study was designed to explore the radioprotective effect of T3, and if so, its potential mechanisms. MATERIALS AND METHODS: KunMing mice were exposed to various doses of γ irradiation (60 Co) after being treated with dimethyl sulfoxide (DMSO) or T3. Briefly, survival rate, dose reducing factor (DRF), body weight change (%), spleen index (SI) and thymus index (TI) of irradiated mice with or without different doses of T3 treatment were evaluated routinely...
May 19, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28440431/gdf-15-gene-expression-alterations-in-human-lymphoblastoid-cells-and-peripheral-blood-lymphocytes-following-exposure-to-ionizing-radiation
#10
Shuang Li, Qing-Zhao Zhang, De-Qin Zhang, Jiang-Bin Feng, Qun Luo, Xue Lu, Xin-Ru Wang, Kun-Peng Li, De-Qing Chen, Xiao-Feng Mu, Ling Gao, Qing-Jie Liu
The identification of rapid, sensitive and high‑throughput biomarkers is imperative in order to identify individuals harmed by radiation accidents, and accurately evaluate the absorbed doses of radiation. DNA microarrays have previously been used to evaluate the alterations in growth/differentiation factor 15 (GDF15) gene expression in AHH‑1 human lymphoblastoid cells, following exposure to γ‑rays. The present study aimed to characterize the relationship between the dose of ionizing radiation and the produced effects in GDF‑15 gene expression in AHH‑1 cells and human peripheral blood lymphocytes (HPBLs)...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28438149/anti-depressant-and-anxiolytic-potential-of-acacia-hydaspica-r-parker-aerial-parts-extract-modulation-of-brain-antioxidant-enzyme-status
#11
Tayyaba Afsar, Suhail Razak, Muhammad Rashid Khan, Ali Almajwal
BACKGROUND: Oxidative stress may link to psychiatric disorders, and is being regarded as a plausible mechanism that can affect the regulation of these illnesses. The present study was undertaken to investigate the antidepressant and anxiolytic potential of A. hydaspica R. parkers. Brain oxidative stress enzyme levels were analyzed to correlate depression and stress with brain antioxidant status. METHODS: Antidepressant and anxiolytic effect of methanol extract of A...
April 24, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28388563/benzene-and-its-metabolite-decreases-cell-proliferation-via-lncrna-obfc2a-mediated-anti-proliferation-effect-involving-notch1-and-klf15
#12
Pengling Sun, Jing Wang, Xiaoli Guo, Yujiao Chen, Caihong Xing, Ai Gao
LncRNA has been considered to play a crucial role in the progression of several diseases by affecting cell proliferation. However, its role in benzene toxicity remains unclear. Our study showed that the expression of lncRNA-OBFC2A increased accompanied with the change of cell proliferation related-genes in benzene-exposed workers. In vitro experiments, 1,4-Benzoquinone dose-dependently inhibited cell proliferation and simultaneously caused the decrease of NOTCH1 expression and the increase of KLF15 in AHH-1 cell lines...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28372687/pharmacokinetics-and-pharmacodynamics-of-cisatracurium-in-patients-undergoing-surgery-with-two-hemodilution-methods
#13
Jianrong Guo, Xiaohong Yuan, Xiaofang Zhou, Xiaoju Jin
OBJECTIVE: To investigate the pharmacokinetics and pharmacodynamics of cisatracurium in patients undergoing surgery under acute normovolemic hemodilution (ANH) and acute hypervolemic hemodilution (AHH). METHODS: Ninety patients with orthopedic surgery were divided into ANH, AHH and control groups, which received hemodilution by hydroxyethyl starch 130/0.4 transfusion, Voluven transfusion and regular transfusion and infusion during surgery, respectively. Each group was divided into 3 sub-groups, administrated with cisatracurium at dosage of 0...
May 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27802299/protective-effects-of-essential-oils-as-natural-antioxidants-against-hepatotoxicity-induced-by-cyclophosphamide-in-mice
#14
Salah A Sheweita, Lobna S El-Hosseiny, Munther A Nashashibi
Clinical application of cyclophosphamide (CP) as an anticancer drug is often limited due to its toxicity. CP is metabolized mainly in the liver by cytochrome P450 system into acrolein which is the proximate toxic metabolite. Many different natural antioxidants were found to alleviate the toxic effects of various toxic agents via different mechanisms. Therefore, the present study aimed at investigating the role of essential oils extracted from fennel, cumin and clove as natural antioxidants in the alleviation of hepatotoxicity induced by CP through assessment of hepatotoxicity biomarkers (AST, ALT, ALP), histopathology of liver tissues as well as other biochemical parameters involved in the metabolism of CP...
2016: PloS One
https://www.readbyqxmd.com/read/27800121/erectile-dysfunction-drugs-changed-the-protein-expressions-and-activities-of-drug-metabolising-enzymes-in-the-liver-of-male-rats
#15
Salah A Sheweita, Mona Wally, Mostafa Hassan
Erectile dysfunction (ED) is a major health problem and is mainly associated with the persistent inability of men to maintain sufficient erection for satisfactory sexual performance. Millions of men are using sildenafil, vardenafil, and/or tadalafil for ED treatment. Cytochrome P450s (CYPs) play a central role in the metabolism of a wide range of xenobiotics as well as endogenous compounds. Susceptibility of individuals to the adverse effects of different drugs is mainly dependent on the expression of CYPs proteins...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27637481/a-comparison-of-the-genotoxicity-of-benzo-a-pyrene-in-four-cell-lines-with-differing-metabolic-capacity
#16
COMPARATIVE STUDY
Ume-Kulsoom Shah, Anna L Seager, Paul Fowler, Shareen H Doak, George E Johnson, Sharon J Scott, Andrew D Scott, Gareth J S Jenkins
Benzo[a]pyrene (B[a]P) is a known genotoxin and carcinogen, yet its genotoxic response at low level exposure has not been determined. This study was conducted to examine the interplay of dose and metabolic capacity on genotoxicity of B[a]P. Investigating and better understanding the biological significance of low level chemical exposures will help improve human health risk assessments. The genotoxic and mutagenic effects of B[a]P were investigated using human cell lines (AHH-1, MCL-5, TK6 and HepG2) with differential expression of the CYP450 enzymes CYP1A1, 1B1 and1A2 involved in B[a]P metabolism...
September 15, 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27477798/fluorescence-versus-x-ray-cholangiography-during-laparoscopic-cholecystectomy-protocol-for-a-randomised-trial
#17
RANDOMIZED CONTROLLED TRIAL
Lars Lang Lehrskov, Søren S Larsen, Billy B Kristensen, Thue Bisgaard
INTRODUCTION: Intraoperative fluorescent cholangiography is a novel non-invasive imaging technique to visualise the extrahepatic biliary tract during laparoscopic cholecystectomy. It has been proven feasible, fast and cost effective. Never-theless, there is only sparse data on the capacity of fluorescent cholangiography to visualise the biliary anatomy. METHODS: Based on a non-inferiority design, patients with complicated gallstone disease are randomised to either -intraoperative conventional X-ray cholangiography (reference group, n = 60) or intraoperative fluorescent cholangiography (n = 60)...
August 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27429710/radioprotective-effect-of-grape-seed-proanthocyanidins-in-vitro-and-in-vivo
#18
Yijuan Huang, Hainan Zhao, Kun Cao, Ding Sun, Yanyong Yang, Cong Liu, Jianguo Cui, Ying Cheng, Bailong Li, Jianming Cai, Fu Gao
We have demonstrated that grape seed proanthocyanidins (GSPs) could effectively scavenge hydroxyl radical (•OH) in a dose-dependent manner. Since most of the ionizing radiation- (IR-) induced injuries were caused by •OH, this study was to investigate whether GSPs would mitigate IR-induced injuries in vitro and in vivo. We demonstrated that GSPs could significantly reduce IR-induced DNA strand breaks (DSBs) and apoptosis of human lymphocyte AHH-1 cells. This study also showed that GSPs could protect white blood cells (WBC) from IR-induced injuries, speed up the weight of mice back, and decrease plasma malondialdehyde (MDA), thus improving the survival rates of mice after ionizing radiation...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27272250/buffalo-bubalus-bubali-late-embryo-and-foetus-development-a-morphological-analysis
#19
A C Morini, Ncg Pieri, Kcs Roballo, D S Martins, C E Ambrósio, J C Morini Junior, P O Favaron, Ahh Minervino, Fvt Pereira, M A Miglino
Many researches describe the embryonic developmental features in domestic animals; however, in farm animals, they are scarce. Most farm animal studies are related to assisted reproduction and embryos transfer techniques. But, morphological features and size measure to estimate the age gestation are rarely reported in literature. Thus, in this study, we described the developmental changes in the bubaline (Bubalus bubali) concepts from 21 to 60 days of gestation. Our results revealed that buffalo embryos similar morphological characteristics similar to other mammalian species...
August 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27231887/ethanolic-extract-of-acanthopanax-koreanum-nakai-alleviates-alcoholic-liver-damage-combined-with-a-high-fat-diet-in-c57bl-6j-mice
#20
Haein Kim, Minyoung Park, Jae-Ho Shin, Oran Kwon
Alcoholic and nonalcoholic liver steatosis have an indistinguishable spectrum of histological features and liver enzyme elevations. In this study, we investigated the potential of the ethanolic extract of Acanthopanax koreanum Nakai (AK) to protect against experimental alcoholic liver disease in a mouse model that couples diet and daily ethanol bolus gavage. Fifty-six C57BL/6J mice were randomly divided into seven groups: normal control (NC), alcohol control (AC), alcohol/HFD control (AH), low-dose (1%) AK in alcohol group (ACL), high-dose (3%) AK in alcohol group (ACH), low-dose AK in alcohol/HFD group (AHL), and high-dose AK in alcohol/HFD group (AHH)...
May 24, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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