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https://www.readbyqxmd.com/read/29441722/the-growing-importance-of-lesion-volume-as-a-prognostic-factor-in-patients-with-multiple-brain-metastases-treated-with-stereotactic-radiosurgery
#1
David M Routman, Shelly X Bian, Kevin Diao, Jonathan L Liu, Cheng Yu, Jason Ye, Gabriel Zada, Eric L Chang
Stereotactic Radiosurgery (SRS) is considered standard of care for patients with 1-3 brain metastases (BM). Recent observational studies have shown equivalent OS in patients with 5+ BM compared to those with 2-4, suggesting SRS alone may be appropriate in these patients. We aim to review outcomes of patients treated with SRS with 2-4 versus 5+ BM. This analysis included consecutive patients from 1994 to 2015 treated with SRS. Of 1017 patients, we excluded patients with a single BM and patients without adequate survival data, resulting in 391 patients...
February 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29434151/primary-central-nervous-system-post-transplant-lymphoproliferative-disorder-diagnosed-by-peripheral-facial-nerve-palsy
#2
Aya Imafuku, Kiho Tanaka, Yuji Marui, Yoshifumi Ubara, Kenmei Takaichi, Shinji Tomikawa, Yasunori Ota, Takeshi Fujii, Yasuo Ishii
Although primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) causes various symptoms depending on the tumor region, there has been no previous report of PCNS-PTLD in the cerebellopontine angle that was diagnosed due to peripheral facial nerve palsy. We herein report a case involving a 62-year-old man with PCNS-PTLD in the cerebellopontine angle who was diagnosed due to peripheral facial nerve palsy. The reduction of immunosuppressive therapy, whole-brain radiotherapy, intrathecal chemotherapy, and rituximab were effective in treating this patient...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29404305/profile-of-patients-undergoing-palliative-radiotherapy-a-single-institute-study-from-a-tertiary-care-oncology-center
#3
Virender Suhag, B S Sunita, Pankaj Vats, Nilotpal Chakravarty, Mayuri Jain, Rekha S Vashisht
Background: Palliative radiotherapy (PRT) plays a significant role in the palliation of symptoms in patients with cancer and constitutes nearly 50% of the workload in different settings. Aims: The aim is to study patient-, disease-, and treatment-related characteristics in locoregionally advanced and metastatic malignancies meriting palliative management. Setting and Design: This was a retrospective observational study in a tertiary care government institute with academic and research potential...
October 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29392582/intrathecal-trastuzumab-in-the-management-of-her2-breast-leptomeningeal-disease-a-single-institution-experience
#4
Nicholas B Figura, Wendy Long, Michael Yu, Timothy J Robinson, Sepideh Mokhtari, Arnold B Etame, Nam D Tran, Roberto Diaz, Hatem Soliman, Heather S Han, Solmaz Sahebjam, Peter A Forsyth, Kamran A Ahmed
PURPOSE: Leptomeningeal disease is a rare and devastating presentation of advanced stage metastatic breast cancer with historically poor overall survival. We assessed the safety and feasibility of intrathecal (IT) trastuzumab in HER2+ leptomeningeal disease. METHODS: A total of 13 patients were treated at our institution with IT trastuzumab beginning November 2012 and followed until November 2017. Outcomes including craniospinal progression as well as overall survival (OS) following initiation of IT trastuzumab were assessed from review of the clinical chart and radiologic examinations...
February 1, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29389234/duration-of-anti-programmed-death-1-therapy-in-advanced-melanoma-how-much-of-a-good-thing-is-enough
#5
Nikhil I Khushalani
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
February 1, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29382032/a-rare-case-of-cavitary-lung-cancer-complicated-with-mycotic-pneumonia-and-bullous-emphysema-a-case-report-and-review-of-the-literature
#6
Cun-Tao Lu, Rui-Mei Zhang, Heng Wang, Feng-Wei Kong, Wen-Bin Wu, Long-Bo Gong, Miao Zhang
RATIONALE: The accurate diagnosis and staging of cavitary lung cancer is challenging but essential for the choice of therapy; therefore, the differential diagnosis of cystic pulmonary lesions needs to be elucidated. PATIENT CONCERNS: A patient was admitted with multifocal thin-walled cystic lesions in chest computed tomography. DIAGNOSES: The patient had been diagnosed as heterogeneous bullous emphysema pathologically about 3 years ago. His diagnosis turned out to be metastatic cavitary lung cancer complicated with fungal pneumonia this time...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29376195/efficacy-safety-and-outcome-of-frameless-image-guided-robotic-radiosurgery-for-brain-metastases-after-whole-brain-radiotherapy
#7
Laura-Nanna Lohkamp, Peter Vajkoczy, Volker Budach, Markus Kufeld
Estimating efficacy, safety and outcome of frameless image-guided robotic radiosurgery for the treatment of recurrent brain metastases after whole brain radiotherapy (WBRT). We performed a retrospective single-center analysis including patients with recurrent brain metastases after WBRT, who have been treated with single session radiosurgery, using the CyberKnife® Radiosurgery System (CKRS) (Accuray Inc., CA) between 2011 and 2016. The primary end point was local tumor control, whereas secondary end points were distant tumor control, treatment-related toxicity and overall survival...
January 29, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29373273/generation-of-a-new-disease-specific-prognostic-score-for-patients-with-brain-metastases-from-small-cell-lung-cancer-treated-with-whole-brain-radiotherapy-bms-score-and-validation-of-two-other-indices
#8
Denise Bernhardt, Laila König, Sophie Aufderstrasse, Johannes Krisam, Juliane Hoerner-Rieber, Sebastian Adeberg, Farastuk Bozorgmehr, Rami El Shafie, Kristin Lang, Jutta Kappes, Michael Thomas, Felix Herth, Claus Peter Heußel, Arne Warth, Samuel Marcrom, Jürgen Debus, Martin Steins, Stefan Rieken
INTRODUCTION: Patients with small-cell lung cancer (SCLC) demonstrate an exception in the treatment of brain metastases (BM), because in patients with SCLC whole brain radiotherapy (WBRT) only is the preferred treatment modality. The purpose of this study was to develop a prognostic score for patients with brain metastases from SCLC treated with WBRT. PATIENTS AND METHODS: The present study was conducted utilizing a single-institution, previously described, retrospective database of patients with SCLC who were treated with WBRT (n = 221)...
December 15, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29372103/brain-metastasis-in-advanced-colorectal-cancer-results-from-the-south-australian-metastatic-colorectal-cancer-samcrc-registry
#9
Gonzalo Tapia Rico, Timothy J Price, Christos Karapetis, Cynthia Piantadosi, Rob Padbury, Amitesh Roy, Guy Maddern, James Moore, Scott Carruthers, David Roder, Amanda R Townsend
Objective: Brain metastasis is considered rare in metastatic colorectal cancer (mCRC); thus, surveillance imaging does not routinely include the brain. The reported incidence of brain metastases ranges from 0.6% to 3.2%. Methods: The South Australian mCRC Registry (SAmCRC) was analyzed to assess the number of patients presenting with brain metastasis during their lifetime. Due to small numbers, a descriptive analysis is presented. Results: Only 59 patients of 4,100 on the registry at the time of analysis had developed brain metastasis (1...
November 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29370839/efficacy-of-t-dm1-for-leptomeningeal-and-brain-metastases-in-a-her2-positive-metastatic-breast-cancer-patient-new-directions-for-systemic-therapy-a-case-report-and-literature-review
#10
Giuseppina Rosaria Rita Ricciardi, Alessandro Russo, Tindara Franchina, Silvia Schifano, Giampiero Mastroeni, Anna Santacaterina, Vincenzo Adamo
BACKGROUND: Herein, we report a complete response after whole brain radiotherapy (WBRT) and concomitant T-DM1 in a patient with HER2-positive metastatic breast cancer (MBC) and extensive brain and leptomeningeal involvement. CASE PRESENTATION: A 46 years old Caucasian woman with HER2-positive MBC and no baseline CNS involvement, started in August 2015 1st line therapy with Pertuzumab-Trastuzumab-Docetaxel, with partial response. However, in April 2016 the patient eventually progressed with emergence of brain and leptomeningeal metastases...
January 25, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29365347/whole-brain-radiotherapy-for-the-treatment-of-newly-diagnosed-multiple-brain-metastases
#11
REVIEW
May N Tsao, Wei Xu, Rebecca Ks Wong, Nancy Lloyd, Normand Laperriere, Arjun Sahgal, Eileen Rakovitch, Edward Chow
BACKGROUND: This is an update to the review published in the Cochrane Library (2012, Issue 4).It is estimated that 20% to 40% of people with cancer will develop brain metastases during the course of their illness. The burden of brain metastases impacts quality and length of survival. OBJECTIVES: To assess the effectiveness and adverse effects of whole brain radiotherapy (WBRT) given alone or in combination with other therapies to adults with newly diagnosed multiple brain metastases...
January 25, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29356790/clinical-and-radiological-response-of-braf-inhibition-and-mek-inhibition-in-patients-with-brain-metastases-from-braf-mutated-melanoma
#12
Marnix H Geukes Foppen, Willem Boogerd, Christian U Blank, Johannes V van Thienen, John B Haanen, Dieta Brandsma
Patients with brain metastases (BM) from melanoma have an overall survival (OS) of 2-6 months after whole-brain radiotherapy. Targeted therapy (TT) is an effective treatment for BRAF-mutated metastatic melanoma. Moreover, recent studies indicate intracranial responses of TT in patients with BM. We analyzed 146 patients with BM from BRAF-mutated melanoma treated with vemurafenib, dabrafenib, or dabrafenib+trametinib between 2010 and 2016. We determined clinical and radiological response, progression-free survival (PFS), and OS...
January 19, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29354805/current-progress-and-outcomes-of-clinical-trials-on-using-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitor-therapy-in-non-small-cell-lung-cancer-patients-with-brain-metastases
#13
Ling-Ling Kong, Lin-Lin Wang, Li-Gang Xing, Jin-Ming Yu
Non-small cell lung cancer (NSCLC) continues to be one of the major causes of cancer-related deaths worldwide, and brain metastases are the major cause of death in NSCLC patients. With recent advances in understanding the underlying molecular mechanism of NSCLC development and progression, mutations in epidermal growth factor receptor (EGFR) have been recognized as a key predictor of therapeutic sensitivity to EGFR tyrosine kinase inhibitors (TKIs). Using EGFR-TKI alone or in combination with standard treatments such as whole-brain radiotherapy and surgery has been an effective strategy for the management of brain metastasis...
December 2017: Chronic diseases and translational medicine
https://www.readbyqxmd.com/read/29344836/boost-irradiation-integrated-to-whole-brain-radiotherapy-in-the-management-of-brain-metastases
#14
Ágnes Dobi, Emese Fodor, Anikó Maráz, Zsófia Együd, Adrienne Cserháti, László Tiszlavicz, Zita Reisz, Pál Barzó, Zoltán Varga, Katalin Hideghéty
Our retrospective analysis aimed to evaluate the clinical value of dose intensification schemes: WBRT and consecutive, delayed, or simultaneous integrated boost (SIB) in brain metastasis (BM) management. Clinical data and overall survival (OS) of 468 patients with BM from various primaries treated with 10 × 3 Gy WBRT (n = 195), WBRT+ 10 × 2 Gy boost (n = 125), or simultaneously 15 × 2.2 Gy WBRT+0.7 Gy boost (n = 148) during a 6-year period were statistically analysed. Significant difference in OS could be detected with additional boost to WBRT (3...
January 17, 2018: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29337140/characteristics-and-prognostic-factors-for-patients-with-her2-overexpressing-breast-cancer-and-brain-metastases-in-the-era-of-her2-targeted-therapy-an-argument-for-earlier-detection
#15
Aki Morikawa, Rui Wang, Sujata Patil, Adi Diab, Jonathan Yang, Clifford A Hudis, Heather L McArthur, Kathryn Beal, Andrew D Seidman
BACKGROUND: Although brain metastases (BM) are associated with poor prognosis, patients with human epidermal growth factor receptor 2 (HER2) overexpressing (HER2+) breast cancer (BC) with BM who are treated with anti-HER2 therapy have a relatively longer survival after BM diagnosis compared with other subtypes and HER2+ patients previously untreated with anti-HER2 therapy. It is unclear if previously reported prognostic factors are applicable to patients with HER2+ BC in the era of HER2-targeted therapy...
December 21, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29332467/is-hippocampal-avoidance-during-whole-brain-radiotherapy-risky-for-patients-with-small-cell-lung-cancer-hippocampal-metastasis-rate-and-associated-risk-factors
#16
Esra Korkmaz Kirakli, Ozgur Oztekin
OBJECTIVES: Hippocampal avoidance during whole-brain radiotherapy is performed to prevent neural stem cell injury causing neurocognitive dysfunction. Nevertheless, the estimated risk of metastases in hippocampal avoidance area in small-cell lung cancer is unknown. The current study aimed to characterize the metastatic distribution within the brain relative to the hippocampus, estimate the incidence of hippocampal metastasis in patients with small-cell lung cancer, and identify clinical and radiographic variables that may be associated with the risk of hippocampal avoidance area metastasis...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29325248/-survival-of-patients-with-primary-central-nervous-system-diffuse-large-b-cell-lymphoma-impact-of-gene-aberrations-and-protein-overexpression-of-bcl-2-and-c-myc-and-selection-of-chemotherapy-regimens
#17
W J Yin, X Zhu, H Y Yang, W Y Sun, M J Wu
Objective: To investigate the impact of clinicopathological features, gene rearrangements and protein expression of bcl-6, bcl-2, C-MYC and chemotherapy regime on the prognosis of patients with primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL). Methods: Thirty-three cases of PCNS-DLBCL diagnosed from January 2006 to December 2016 at Zhejiang Cancer Hospital were collected. The expression of CD10, bcl-6, bcl-2, MUM1 and MYC were detected by immunohistochemical staining (IHC). The presence of EB virus was detected by in situ hybridization(EBER)...
January 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29317366/management-of-solitary-intracranial-metastases-of-differentiated-thyroid-carcinoma-11-pathologically-confirmed-cases-and-systematic-literature-review
#18
Mingyu Chen, Danqi Chen, Jian Xu, Ming Xu, Ping Zhong
BACKGROUND: Solitary intracranial metastases of differentiated thyroid carcinoma (DTC) are rare and the management is still controversial. This research is aim to seek for the suitable therapeutic methods of this disease. METHODS: We retrospectively studied 11 pathologically confirmed cases of solitary intracranial metastases of DTC in a single institution from January 2000 to December 2016 and systematically reviewed 52 cases of this disease out of 416 cases presented in the literature on Pubmed...
January 6, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29316943/are-prognostic-indices-for-brain-metastases-of-melanoma-still-valid-in-the-stereotactic-era
#19
Harun Badakhshi, Fidelis Engeling, Volker Budach, Pirus Ghadjar, Sebastian Zschaeck, David Kaul
BACKGROUND: Malignant melanoma brain metastases (MBM) are the third most common cause for brain metastases (BM). Historically Whole-brain radiotherapy (WBRT) was considered the goldstandard of treatment even though melanoma cells are regarded as very radioresistant. Therapeutic possibilities have fundamentally changed since the availability of stereotactic radiotherapy (SRT), where it is possible to apply high ablative doses in a very precise manner. In this work we analyze prognostic factors of overall survival (OS) after SRT in patients with MBM and evaluate the applicability of popular prognostic indices that mainly stem from the WBRT-era...
January 10, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29290994/radiotherapy-as-an-alternative-treatment-option-for-primary-central-nervous-system-lymphoma-patients-who-are-noncandidates-for-chemotherapy
#20
Yoo-Kang Kwak, Byung-Ock Choi, Kyu Hye Choi, Jong Hoon Lee, Soo Yoon Sung, Yun Hee Lee
The standard treatment for primary central nervous system (CNS) lymphoma is based on chemotherapy. However, there are patients who are not indicated for chemotherapy and when left untreated, the expected functional outcomes for these patients are devastating since the disease causes various neurologic symptoms. Therefore, we assessed the effects of radiotherapy as an alternative therapy in primary CNS lymphoma. Thirty-two patients were diagnosed with primary CNS lymphoma and treated with radiotherapy alone...
December 5, 2017: Oncotarget
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