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https://www.readbyqxmd.com/read/28820844/a-new-method-for-reconstruction-of-vermilion-deficiency-in-cleft-lip-deformity-the-bi-winged-myomucosa-switch-flap
#1
KyungHoon Chung, Lun-Jou Lo
BACKGROUND: This study reviewed the method of using "Bi-winged myomucosa switch flap" for correction of secondary cleft lip deformity in patients with vermilion mucosa deficiency, lack of the central tubercle and disproportionate lip projection, obviating the conventional Abbé flap when the prolabium has acceptable philtrum and Cupid's bow definition. METHODS: The technique was applied to adult patients with secondary vermilion deficiency after primary bilateral cleft lip repair...
August 8, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28819731/erratum-to-a-novel-tubulin-polymerization-inhibitor-mpt0b206-downregulates-bcr-abl-expression-and-induces-apoptosis-in-imatinib-sensitive-and-imatinib-resistant-cml-cells
#2
Chih-Wei Chen, Yueh-Lun Lee, Jing-Ping Liou, Yu-Hsiu Liu, Chin-Wei Liu, Tsai-Yun Chen, Huei-Mei Huan
No abstract text is available yet for this article.
August 18, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28819181/capnography-monitoring-the-hypoventilation-during-the-induction-of-bronchoscopic-sedation-a-randomized-controlled-trial
#3
Ting-Yu Lin, Yueh-Fu Fang, Shih-Hao Huang, Tsai-Yu Wang, Chih-Hsi Kuo, Hau-Tieng Wu, Han-Pin Kuo, Yu-Lun Lo
We hypothesize that capnography could detect hypoventilation during induction of bronchoscopic sedation and starting bronchoscopy following hypoventilation, may decrease hypoxemia. Patients were randomized to: starting bronchoscopy when hypoventilation (hypopnea, two successive breaths of at least 50% reduction of the peak wave compared to baseline or apnea, no wave for 10 seconds) (Study group, n = 55), or when the Observer Assessment of Alertness and Sedation scale (OAAS) was less than 4 (Control group, n = 59)...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28813495/establishing-failure-predictors-for-the-planned-extubation-of-overweight-and-obese-patients
#4
Chien-Ming Chao, Chih-Cheng Lai, Ai-Chin Cheng, Shyh-Ren Chiang, Wei-Lun Liu, Chung-Han Ho, Shu-Chen Hsing, Chin-Ming Chen, Kuo-Chen Cheng
We investigated failure predictors for the planned extubation of overweight (body mass index [BMI] = 25.0-29.9) and obese (BMI ≥ 30) patients. All patients admitted to the adult intensive care unit (ICU) of a tertiary hospital in Taiwan were identified. They had all undergone endotracheal intubation for > 48 h and were candidates for extubation. During the study, 595 patients (overweight = 458 [77%]); obese = 137 [23%]) with planned extubation after weaning were included in the analysis; extubation failed in 34 patients (5...
2017: PloS One
https://www.readbyqxmd.com/read/28811626/outbreak-and-genotyping-of-canine-distemper-virus-in-captive-siberian-tigers-and-red-pandas
#5
He Zhang, Fen Shan, Xia Zhou, Bing Li, Jun-Qiong Zhai, Shu-Zhan Zou, Meng-Fan Wu, Wu Chen, Shao-Lun Zhai, Man-Lin Luo
In this study, four canine distemper virus (CDV) strains were isolated from captive Siberian tigers (Panthera tigris altaica) and red pandas (Ailurus fulgens) during two separate CDV outbreaks in a zoo in Guangdong province, China. Sequence alignment and phylogenetic analyses based on the full-length hemagglutinin (H) and fusion (F) genes showed that they were closely identical to genotype Asia-1. Prior to confirmation of CDV in Siberian tigers, to control spread of the disease, a live attenuated combination CDV vaccine was used among almost all carnivore animals except for red pandas in which another recombinant combination CDV vaccine was used...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811008/serum-wisteria-floribunda-agglutinin-positive-mac-2-binding-protein-expression-predicts-disease-severity-in-chronic-hepatitis-c-patients
#6
Ching-I Huang, Chung-Feng Huang, Ming-Lun Yeh, Yi-Hung Lin, Po-Cheng Liang, Meng-Hsuan Hsieh, Chia-Yen Dai, Ming-Yen Hsieh, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Ming-Lung Yu, Wan-Long Chuang
Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA(+)-M2BP) has recently been developed as a promising liver fibrosis glyco biomarker. We assessed its efficacy in evaluating liver disease severity in chronic hepatitis C (CHC) in Taiwan. The association between WFA(+)-M2BP and histological features was evaluated among those CHC patients underwent liver biopsy. We also aimed to clarify the factors determining the performance of WFA(+)-M2BP in CHC. A total of 229 CHC patients were consecutively recruited...
August 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28810350/-analysis-of-compiling-date-of-huang-di-nei-jing-huangdi-s-internal-classic
#7
W B Zhang, Y T Gao, H Y Li
There are Seven Medical Classics recorded in the Han shu Yi wen zhi(Bibliography in Annals of the Han Dynasty), among which the 18-volume Huang di nei jing (Huangdi's Internal Classic) is not the current edition of Ling shu (Miraculous Pivot) and Su wen(Plain Questions). The present edition of Huang di nei jing containing these two works might be merged in the Eastern Han Dynasty, benefited from the invention of Cai Lun's papermaking technique and the development of Nine needles, especially filiform needle manufacturing...
May 28, 2017: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/28809781/ac2-26-an-annexin-a1-peptide-attenuates-ischemia-reperfusion-induced-acute-lung-injury
#8
Wen-I Liao, Shu-Yu Wu, Geng-Chin Wu, Hsin-Ping Pao, Shih-En Tang, Kun-Lun Huang, Shi-Jye Chu
Annexin A1 (AnxA1) is an endogenous protein that modulates anti-inflammatory processes, and its therapeutic potential has been reported in a range of inflammatory diseases. The effect of AnxA1 on ischemia-reperfusion (IR)-induced lung injury has not been examined. In this study, isolated, perfused rat lungs were subjected to IR lung injury induced by ischemia for 40 min, followed by reperfusion for 60 min. The rat lungs were randomly treated with vehicle (phosphate-buffered saline), and Ac2-26 (an active N-terminal peptide of AnxA1) with or without an N-formyl peptide receptor (FPR) antagonist N-Boc-Phe-Leu-Phe-Leu-Phe (Boc2)...
August 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28809601/detection-and-treatment-of-monoclonal-gammopathy-of-renal-significance-with-progression-to-light-chain-deposition-disease
#9
Gheorghe Ciprian Cazan, Kirk Foster, Matthew A Lunning, Ketki Tendulkar
No abstract text is available yet for this article.
August 15, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28809395/cryo-em-structures-of-the-80s-ribosomes-from-human-parasites-trichomonas-vaginalis-and-toxoplasma-gondii
#10
Zhifei Li, Qiang Guo, Lvqin Zheng, Yongsheng Ji, Yi-Ting Xie, De-Hua Lai, Zhao-Rong Lun, Xun Suo, Ning Gao
As an indispensable molecular machine universal in all living organisms, the ribosome has been selected by evolution to be the natural target of many antibiotics and small-molecule inhibitors. High-resolution structures of pathogen ribosomes are crucial for understanding the general and unique aspects of translation control in disease-causing microbes. With cryo-electron microscopy technique, we have determined structures of the cytosolic ribosomes from two human parasites, Trichomonas vaginalis and Toxoplasma gondii, at resolution of 3...
August 15, 2017: Cell Research
https://www.readbyqxmd.com/read/28803715/a-phase-1-randomized-open-label-clinical-study-to-evaluate-the-safety-and-tolerability-of-a-novel-recombinant-hepatitis-e-vaccine
#11
Yu-Feng Cao, Hong Tao, Yue-Mei Hu, Cheng-Bo Shi, Xing Wu, Qi Liang, Chun-Ping Chi, Li Li, Zheng-Lun Liang, Ji-Hong Meng, Feng-Cai Zhu, Zhao-Hui Liu, Xin-Ping Wang
BACKGROUND: This study aimed to evaluate the safety and tolerability for variable dosages of a novel hepatitis E vaccine p179. METHODS: The randomized open-label parallel control phase 1 clinical trial enrolled 120 eligible participants aged 16-65years in Jiangsu Province, China. The experimental groups were randomized to receive different dosages of 20μg, 30μg, and 40μg Hepatitis E Virus (HEV) p179 vaccines, with the 30μgHEV vaccine p239 Hecolin as control, and vaccinated at 0, 1 and 6month intervals...
August 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28800110/response-of-dermal-fibroblasts-to-biochemical-and-physical-cues-in-aligned-polycaprolactone-silk-fibroin-nanofiber-scaffolds-for-application-in-tendon-tissue-engineering
#12
Chih-Hao Chen, Shih-Hsien Chen, Chang-Yi Kuo, Meng-Lun Li, Jyh-Ping Chen
Silk fibroin (SF) and fiber alignment were introduced into polycaprolactone (PCL)-based electrospun nanofibers as chemical and physical cues for tendon tissue engineering applications. The physicochemical properties of random PCL (RP) nanofibers, random PCL/SF (RPSF) nanofibers and aligned PCL/SF (APSF) nanofibers were characterized for fiber orientation and SF blending effects. An in vitro cell culture with rabbit dermal fibroblasts (RDFBs) on nanofibers indicated that SF promotes cell proliferation to a higher extent than fiber alignment...
August 11, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28799599/thermal-dependence-of-nanofluidic-energy-conversion-by-reverse-electrodialysis
#13
Junho Hwang, Tatsuki Sekimoto, Wei-Lun Hsu, Sho Kataoka, Akira Endo, Hirofumi Daiguji
The thermal dependence of salinity-gradient-driven energy conversion by reverse electrodialysis using a mesoporous silica thin film with pores ca. 2-3 nm in diameter was studied in a temperature range of 293-333 K. As the temperature increases, the surface charge density of mesopores increases owing to an increase in the zeta potential of the pore walls, which in turn increases the concentration of counter-ions in the electrical double layer. The ion mobility also increases with increasing temperature owing to a decrease in the liquid viscosity...
August 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28798401/the-tyrosine-kinase-inhibitor-nintedanib-activates-shp-1-and-induces-apoptosis-in-triple-negative-breast-cancer-cells
#14
Chun-Yu Liu, Tzu-Ting Huang, Pei-Yi Chu, Chun-Teng Huang, Chia-Han Lee, Wan-Lun Wang, Ka-Yi Lau, Wen-Chun Tsai, Tzu-I Chao, Jung-Chen Su, Ming-Huang Chen, Chung-Wai Shiau, Ling-Ming Tseng, Kuen-Feng Chen
Triple-negative breast cancer (TNBC) remains difficult to treat and urgently needs new therapeutic options. Nintedanib, a multikinase inhibitor, has exhibited efficacy in early clinical trials for HER2-negative breast cancer. In this study, we examined a new molecular mechanism of nintedanib in TNBC. The results demonstrated that nintedanib enhanced TNBC cell apoptosis, which was accompanied by a reduction of p-STAT3 and its downstream proteins. STAT3 overexpression suppressed nintedanib-mediated apoptosis and further increased the activity of purified SHP-1 protein...
August 11, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28798396/flavonoid-glycosides-isolated-from-epimedium-brevicornum-and-their-estrogen-biosynthesis-promoting-effects
#15
Fu Li, Bao-Wen Du, Dan-Feng Lu, Wen-Xuan Wu, Kanjana Wongkrajang, Lun Wang, Wen-Chen Pu, Chang-Lu Liu, Han-Wei Liu, Ming-Kui Wang, Fei Wang
Epimedium brevicornum Maxim has a long history of use in the treatment of estrogen deficiency-related diseases. However, the chemical constituents and mechanism of action of this medicinal plant are not fully understood. In the present study, we isolated four new isoprenylated flavonoid glycosides, as well as 16 known flavonoids (13 isoprenylated flavonoids), from this plant. The chemical structures of the new flavonoid glycosides were elucidated by extensive spectroscopic analysis. The new compounds 1-4 were potent promoters of estrogen biosynthesis in human ovarian granulosa-like KGN cells...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797539/risk-factors-for-poor-prognosis-in-children-with-refractory-purulent-meningitis-and-the-discharge-criteria
#16
Hai-Lun Peng, Yue Hu, Hong-Jia Chen, Pan-Pan Song, Li Jiang
This study was undertaken to investigate the relationship between cerebrospinal fluid abnormalities and prognosis in pediatric refractory purulent meningitis. Ninety cases of pediatric refractory purulent meningitis were stratified into "good" (n=33) or "poor" (n=57) prognosis groups according to the Glasgow clinical outcome scores. The symptoms, laboratory results, and prognosis were compared by using univariate and multivariate logistic regression analyses. Univariate analysis showed that poor prognosis was associated with: unequal pupil size in both eyes; positive Babinski sign; CSF-WBC >500×10(6)/L, CSF protein concentration >1...
August 7, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28796061/analysis-of-early-onset-bloodstream-infection-due-to-escherichia-coli-infection-in-premature-babies
#17
I-Lun Chen, Hsin-Chun Huang, Chih-Te Wu, Mei-Chen Ou-Yang, Mei-Yung Chung, Chih-Cheng Chen, Jau-Ling Suen, Chih-Hsing Hung
In early-onset bacteremia among preterm neonates, Escherichia coli (E. coli) is the main pathogen and can cause a high mortality rate. Thus, the predictive factors of mortality and extended-spectrum β-lactamase (ESBL)-producing E. coli in preterm babies with E. coli early-onset bacteremia were reported.We retrospectively reviewed preterm neonates who had E. coli bacteremia occurring within 3 days after birth between 2004 and 2015. Maternal and perinatal information were collected from their medical records and analyzed by comparing the survival and nonsurvival groups, and also the ESBL-producing and non-ESBL-producing E...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28795695/structural-stability-of-the-photo-responsive-dna-duplexes-containing-one-azobenzene-via-a-confined-pore
#18
Fu-Na Meng, Zi-Yuan Li, Yi-Lun Ying, Shao-Chuang Liu, Junji Zhang, Yi-Tao Long
Herein, the structural stability of single azobenzene modified DNA duplexes, including the trans form and cis form, has been examined separately based on their distinguishable unzipping kinetics from the mixture by an α-hemolysin nanopore. Furthermore, the accurate isomerization efficiency between the trans and cis form was obtained with single molecule resolution.
August 10, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28791411/microrna-195-inhibits-growth-and-invasion-of-laryngeal-carcinoma-cells-by-directly-targeting-dcun1d1
#19
Shuang Yu, Chao Li, Xuan Zhou, Yongwang Huang, Lun Zhang
MicroRNAs (miRNAs) are a class of small, non-coding RNAs that regulate gene expression and are involved in cell biological processes. The aberrant expression of miR-195 has been found in various types of human cancer. However, the effect of miR‑195 on the initiation and development of laryngeal squamous cell carcinoma (LSCC) remains to be elucidated. Accordingly, in the present study, we detected the expression level of miR-195 in the LSCC and the normal tissues and found that miR-195 were significantly down-regulated in the LSCC tissues...
August 3, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28791302/in-vitro-laser-treatment-platform-construction-with-dental-implant-thread-surface-on-bacterial-adhesion-for-peri-implantitis
#20
Hsien-Nan Kuo, Hsiang-I Mei, Tung-Kuan Liu, Tse-Ying Liu, Lun-Jou Lo, Chun-Li Lin
This study constructs a standard in vitro laser treatment platform with dental implant thread surface on bacterial adhesion for peri-implantitis at different tooth positions. The standard clinical adult tooth jaw model was scanned to construct the digital model with 6 mm bone loss depth on behalf of serious peri-implantitis at the incisor, first premolar, and first molar. A cylindrical suite connected to the implant and each tooth root in the jaw model was designed as one experimental unit set to allow the suite to be replaced for individual bacterial adhesion...
2017: BioMed Research International
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