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Hepatitis adolescent juvenile adult

M R Panasevich, G M Meers, M A Linden, F W Booth, J W Perfield, K L Fritsche, Umesh D Wankhade, Sree V Chintapalli, K Shankar, J A Ibdah, R S Rector
Pediatric obesity and nonalcoholic steatohepatitis (NASH) are on the rise in industrialized countries, yet our ability to mechanistically examine this relationship is limited by the lack of a suitable higher animal models. Here, we examined the effects of high-fat, high-fructose corn syrup, high-cholesterol Western-style diet (WD)-induced obesity on NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine. Juvenile female Ossabaw swine (5 wk old) were fed WD (43.0% fat; 17.8% high-fructose corn syrup; 2% cholesterol) or low-fat diet (CON/lean; 10...
January 1, 2018: American Journal of Physiology. Endocrinology and Metabolism
Gregory L Gaskin, Jason M Glanz, Ingrid A Binswanger, Arash Anoshiravani
This study sought to (1) quantify the baseline immunization coverage of adolescents entering the juvenile justice system and (2) assess the effect of detention-based care on immunization coverage in youth. A cross-sectional retrospective chart review was performed of 279 adolescents detained at a large juvenile detention facility. Only 3% of adolescents had received all study immunizations prior to detention. Before detention, immunization coverage was significantly lower than that for the general adolescent population for all vaccines except the first doses of hepatitis A and varicella-zoster virus vaccines...
July 2015: Journal of Correctional Health Care
Pengyun Wang, Haibin Su, James Underhill, Laura J Blackmore, Maria Serena Longhi, Tassos Grammatikopoulos, Elizabeth Veronica Okokon, Edward T Davies, Diego Vergani, Giorgina Mieli-Vergani, Yun Ma
OBJECTIVE: Familial clustering of juvenile autoimmune liver disease (AILD), including autoimmune hepatitis and autoimmune sclerosing cholangitis (ASC), is rare, despite a high prevalence of autoimmune disorders in AILD families. METHODS: To investigate this discrepancy, we measured autoantibodies diagnostic for AILD, anti-nuclear, anti-smooth muscle, anti-liver kidney microsomal type 1, anti-liver cytosol type 1, and anti-soluble liver antigen antibodies, and human leukocyte antigen profiles in 31 patients and 65 of their first-degree relatives (FDR)...
April 2014: Journal of Pediatric Gastroenterology and Nutrition
Rachel M Deacon, Libby Topp, Handan Wand, Carolyn A Day, Craig Rodgers, Paul S Haber, Ingrid van Beek, Lisa Maher
Despite a safe, effective vaccine, hepatitis B virus (HBV) vaccination coverage remains low among people who inject drugs (PWID). Characteristics of participants screened for a trial investigating the efficacy of financial incentives in increasing vaccination completion among PWID were examined to inform targeting of vaccination programs. Recruitment occurred at two health services in inner-city Sydney that target PWID. HBV status was confirmed via serological testing, and questionnaires elicited demographic, drug use, and HBV risk data...
October 2012: Journal of Urban Health: Bulletin of the New York Academy of Medicine
Mehmet Baha Aytac, Ozgur Kasapcopur, Mustafa Aslan, Tugba Erener-Ercan, Fugen Cullu-Cokugras, Nil Arisoy
OBJECTIVES: In this study, we examined the antibody responses after recombinant hepatitis B vaccine in juvenile SLE patients and whether antibody levels were affected by immunosuppressive therapy. METHODS: This study consisted of 64 juvenile SLE patients and 24 healthy controls. We evaluated HBsAg, Anti-HBs and Anti-HbcIgG titers in SLE patients. 24 patients (37%) were non-immunised, 39 patients were immunised (61%) and 1 patient (1.5%) was chronic hepatitis B carrier...
September 2011: Clinical and Experimental Rheumatology
Charalampos Milionis
BACKGROUND: Greece is a place of settlement for a large number of immigrants, particularly from Albania, which constitute special community groups for public health policies. OBJECTIVES: This study was designed to assess the seroprevalence of serological markers for Hepatitis B and C among juvenile immigrants from Albania settled in Greece. METHODS: The study population included 504 subjects, 418 males and 86 females, aged 10-23 years old who have emigrated from Albania to Pogoniani-Greece and participated voluntarily in vaccination programmes against Hepatitis B...
December 2010: European Journal of General Practice
S Bucher, J Hornung, V Bonkowsky, H Iro, J Zenk
BACKGROUND: High frequency thermotherapy (HFTT) is an established palliative therapy for hepatic malignancies. An in vivo and in vitro trial examined the preconditions for the application of HFTT with liquid-cooled wet electrodes for minimally invasive palliation of head and neck tumors. MATERIAL AND METHOD: HFTT was applied with needle electrodes, cooled with isotonic saline solution, and a high-frequency generator (Elektrotom HiTT 106, Berchtold, Tuttlingen) to porcine tongue and narcotized, juvenile domestic pigs to the tongue and neck, and monitored in realtime by B-mode ultrasound...
April 2010: HNO
David J Templeton, Beverley A Tyson, Joel P Meharg, Katalin E Habgood, Patricia M Bullen, Sharafat Malek, Rick McLean
INTRODUCTION: In Australia, Aboriginal youth are disproportionately represented in juvenile detention centres. We assessed the prevalence of sexually transmissible infections (STIs) and blood-borne viruses (BBVs) identified by an Aboriginal Health Worker (AHW)-led screening program delivered to male detainees of a rural juvenile detention centre. METHODS: A retrospective review of first screening visit data was performed. Demographic and behavioural data were collected and the prevalence of STI/BBV was assessed...
March 2010: Sexual Health
Rochelle E Watkins, Donna B Mak, Crystal Connelly
BACKGROUND: Prison populations are known to be at high risk of sexually transmitted infections (STIs) and blood borne viruses (BBVs). In accordance with State health guidelines, the Western Australian Department of Correctional Services' policy is to offer testing for STIs and BBVs to all new prison entrants. This audit was undertaken to assess the completeness and timeliness of STI and BBV testing among recent prison entrants in Western Australia, and estimate the prevalence of STIs and BBVs on admission to prison...
2009: BMC Public Health
Benjamin C Yan, John A Hart
CONTEXT: Hepatocellular carcinoma is the sixth most common malignancy and the third leading cause of cancer deaths worldwide, making pathologic identification of precursor lesions essential. Recent molecular genetic, pathologic, and clinical data have led to the stratification of hepatic adenomas into subgroups with unique molecular profiles and varying potential for malignant transformation, as well as to the reclassification of telangiectatic focal nodular hyperplasia as telangiectatic adenoma...
July 2009: Archives of Pathology & Laboratory Medicine
S Gander, V Scholten, I Osswald, M Sutton, R van Wylick
STUDY OBJECTIVE: Canada has licensed a human papilloma virus (HPV) vaccine for adolescent females, with the goal of decreasing the incidence of HPV infection and associated cervical cancer. This study identifies the juvenile detainee population as a high-risk group for HPV infection and therefore an important target for primary prevention. DESIGN: A retrospective chart review. SETTING: Sundance Juvenile Detention Center, Kingston, Ontario, Canada...
December 2009: Journal of Pediatric and Adolescent Gynecology
David van der Poorten, Dianna T Kenny, Jacob George
OBJECTIVES: To define and compare the prevalence, risk factors and understanding of hepatitis C transmission among Aboriginal and non-Aboriginal young offenders. DESIGN, PARTICIPANTS AND SETTING: Cross-sectional study of young offenders (aged 12-19 years; median age, 16.6 years) in custody or serving community orders with the New South Wales Department of Juvenile Justice who participated in a physical and mental health survey between March 2002 and December 2005, and who provided blood samples for analysis of biochemistry, bloodborne viruses and sexually transmitted infections...
May 19, 2008: Medical Journal of Australia
J García-Consuegra Molina, R Merino Muñoz, J de Inocencio Arocena
INTRODUCTION: Macrophage activation syndrome (MAS) is a severe complication of systemic juvenile idiopathic arthritis (sJIA). OBJECTIVE: To describe the clinical characteristics and outcome of patients diagnosed with MAS in Spanish pediatric rheumatology units. PATIENTS AND METHOD: A protocol for data collection was designed and distributed to pediatricians and rheumatologists attending children with rheumatic diseases. RESULTS: Information was available from 31 patients (16 boys and 15 girls) who had 37 MAS episodes...
February 2008: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Johanna Uusimaa, Reetta Hinttala, Heikki Rantala, Markku Päivärinta, Riitta Herva, Matias Röyttä, Heidi Soini, Jukka S Moilanen, Anne M Remes, Ilmo E Hassinen, Kari Majamaa
PURPOSE: Polymerase gamma (POLG) is the sole enzyme in the replication of mitochondrial DNA (mtDNA). Numerous mutations in the POLG1 gene have been detected recently in patients with various phenotypes including a classic infantile-onset Alpers-Huttenlocher syndrome (AHS). Here we studied the molecular etiology of juvenile-onset AHS manifesting with status epilepticus and liver disease in three teenagers. PATIENTS AND METHODS: We examined 14- and 17-year-old female siblings (patients 1 and 2) and an unrelated 15-year-old girl (patient 3) with juvenile-onset AHS, sequenced POLG1, and the entire mtDNA, examined mtDNA deletions by amplification of the full-length mtDNA with the long PCR method and used real-time PCR to quantify mtDNA in the tissue samples...
June 2008: Epilepsia
Tony Butler, Josephine M Belcher, Una Champion, Dianna Kenny, Mark Allerton, Michael Fasher
AIMS: To describe the socio-economic background and physical health status of young offenders in custody in New South Wales (Australia). DESIGN: Cross-sectional survey of all young offenders held at nine juvenile detention centres across New South Wales (NSW) (eight male and one female) between January and March 2003. METHODS: Demographic and health information was collected by nurse interviewers and psychologists using a face-to-face interview...
February 2008: Australian and New Zealand Journal of Public Health
L Salleras, A Domínguez, M Bruguera, P Plans, J Costa, N Cardeñosa, J Batalla, A Plasència
AIMS: To analyze the prevalence of hepatitis B virus infection markers and hepatitis B vaccination in a representative sample of the juvenile and adult population of Catalonia and to evaluate the changes with respect to seroepidemiological surveys carried out in 1989 and 1996. DESIGN: In all subjects anti-HBc and anti-HBs antibodies and HBsAg were determined using an ELISA test. The possible association between sociodemographic variables and the prevalence of markers was analysed by calculating the adjusted odd ratio (simple logistic regression)...
December 17, 2007: Vaccine
David Van der Poorten, Dianna T Kenny, Tony Butler, Jacob George
UNLABELLED: Little is known about the health and behavior of adolescent offenders as they relate to abnormalities of liver biochemistry and hepatitis C virus (HCV) infection. A large study of male juvenile offenders was undertaken that allowed a re-evaluation of the normal limits of alanine aminotransferase (ALT), associations with elevated ALT, and HCV antibody positivity. Young offenders (age 12-19 years) serving community orders participated in a wide-ranging health survey and laboratory assessment between October 2003 and December 2005...
December 2007: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Julian A Castaneda, David A Pearce
Humoral autoimmunity against glutamic acid decarboxylase has been described in juvenile Batten disease patients and in the Cln3(-/-) mouse model. To obtain a more comprehensive understanding of the repertoire of antigens targeted, we examined the reactivity of Cln3(-/-) mouse sera to brain proteins from fetal, postnatal and adult rats. Among the candidate antigens identified was alpha-fetoprotein (AFP), a protein that has altered expression in several nervous system disorders and hepatic malignancies. Moreover, AFP levels were upregulated in the brains and livers of postnatal day 14 Cln3(-/-) animals...
January 2008: Neurobiology of Disease
Margaret E Hellard, C K Aitken, J S Hocking
BACKGROUND: Tattooing in prison represents a unique combination of risk factors for blood borne virus (BBV) transmission because it is illicitly performed by untrained operators with homemade, unsterile, and frequently-shared equipment. It occurs in a setting where a high proportion of people are already infected with hepatitis C virus (HCV) and other BBVs. OBJECTIVES: This study measured the frequency of tattoo acquisition by prisoners inside and outside prison, and the associations between tattooing, injecting drug use, and HCV infection risk...
September 2007: American Journal of Infection Control
Christian Marcelli
There is currently no consensus definition of osteopenia and osteoporosis in children according to bone mineral density (BMD) values measured by dual energy x-ray absorptiometry (DXA); interpretation of BMD measures must take into account the child's weight and pubertal status. In children, primary forms of osteoporosis--juvenile idiopathic osteoporosis and osteogenesis imperfecta--are rare; on the other hand, the frequency of secondary osteoporosis is increasing. Fractures, especially of the forearm, are frequent in children...
July 2007: La Presse Médicale
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