Pengyun Wang, Haibin Su, James Underhill, Laura J Blackmore, Maria Serena Longhi, Tassos Grammatikopoulos, Elizabeth Veronica Okokon, Edward T Davies, Diego Vergani, Giorgina Mieli-Vergani, Yun Ma
OBJECTIVE: Familial clustering of juvenile autoimmune liver disease (AILD), including autoimmune hepatitis and autoimmune sclerosing cholangitis (ASC), is rare, despite a high prevalence of autoimmune disorders in AILD families. METHODS: To investigate this discrepancy, we measured autoantibodies diagnostic for AILD, anti-nuclear, anti-smooth muscle, anti-liver kidney microsomal type 1, anti-liver cytosol type 1, and anti-soluble liver antigen antibodies, and human leukocyte antigen profiles in 31 patients and 65 of their first-degree relatives (FDR)...
April 2014: Journal of Pediatric Gastroenterology and Nutrition