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https://www.readbyqxmd.com/read/28194666/increasing-burden-of-chronic-liver-disease-among-adolescents-and-young-adults-in-the-usa-a-silent-epidemic
#1
Iliana Doycheva, Kymberly D Watt, Ghassoub Rifai, Rachel Abou Mrad, Rocio Lopez, Nizar N Zein, William D Carey, Naim Alkhouri
BACKGROUND AND AIMS: Chronic liver disease (CLD) starts or becomes established in the adolescent and young adult (AYA) age group. This study aimed to estimate trends in CLD prevalence among US AYAs and to assess factors associated with CLD. METHODS: Cross-sectional data from 14,547 AYAs (population-weighted N = 68,274,386) aged 15-39 years enrolled in the National Health and Nutrition Examination Survey from 1988 to 2012 were used. Nonalcoholic fatty liver disease (NAFLD) was defined as elevated alanine aminotransferase (>19 U/L for females and >30 U/L for males) in subjects with BMI ≥ 25 kg/m(2); alcoholic liver disease (ALD) as excessive alcohol use (≥3 drinks/day for men and ≥2 drinks/day for women) and elevated aminotransferases after excluding alternative etiologies...
February 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28194210/recommended-immunization-schedule-for-children-and-adolescents-immunization-guideline-8th-edition-released-by-the-korean-pediatric-society-in-2015
#2
REVIEW
Jong-Hyun Kim, Eun Hwa Choi, Su Eun Park, Yae-Jean Kim, Dae Sun Jo, Yun-Kyung Kim, Byung-Wook Eun, Jina Lee, Soo-Young Lee, Hyunju Lee, Ki Hwan Kim, Kyung-Hyo Kim
This report includes the recommended immunization schedule table for children and adolescents based on the 8th (2015) and revised 7th (2012) Immunization Guidelines released by the Committee on Infectious Diseases of the Korean Pediatric Society (KPS). Notable revised recommendations include: reorganization of the immunization table with a list of vaccines on the vertical axis and the corresponding age on the horizontal axis; reflecting the inclusion of Haemophilus influenzae type b vaccine, pneumococcal conjugate vaccine, and hepatitis A vaccine into the National Immunization Program since 2012; addition of general recommendations for 2 new Japanese encephalitis (JE) vaccines and their interchangeability with existing JE vaccines; addition of general recommendations for quadrivalent meningococcal conjugate vaccines and scope of the recommended targets for vaccination; and emphasizing catch-up immunization of Tdap vaccine...
December 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28182307/chronologic-changes-of-serum-hepatitis-b-virus-dna-genotypes-surface-antigen-mutants-and-reverse-transcriptase-mutants-during-25-year-nationwide-immunization-in-taiwan
#3
Hong-Yuan Hsu, Mei-Hwei Chang, Yen-Hsuan Ni, Cheng-Lun Chiang, Jia-Feng Wu, Huey-Ling Chen, Pei-Jer Chen, Ding-Shinn Chen
We investigated breakthrough infection and hepatitis B virus (HBV) genetic changes in immunized subjects after 25-year of a universal infant immunization. Specifically, serum HBV DNA, genotypes, surface antigen mutants and nucleoside analog-resistant (NAr) mutants were assessed in 2853 subjects (<25-years-old) surveyed in 2009, and these data were compared with the data from previous serosurveys. A comparison across different age-stratified groups using the 2009 data revealed a significant increase in the seropositive rate of anti-HBc (5...
February 9, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28172972/p486-immunization-status-of-children-and-adolescents-with-inflammatory-bowel-disease-or-autoimmune-hepatitis-in-germany
#4
L Cagol, K Frivolt, A Krahl, N Förster, E Lainka, P Gerner, D Ney, J Vermehren, S Trenkel, M Radke, S Koletzko, C Posovszky
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28167517/the-need-to-optimize-adolescent-immunization
#5
Henry H Bernstein, Joseph A Bocchini
The adolescent period heralds the pediatric patient's transition into adulthood. It is a time of dynamic development during which effective preventive care measures can promote safe behaviors and the development of lifelong health habits. One of the foundations of preventive adolescent health care is timely vaccination, and every visit can be viewed as an opportunity to update and complete an adolescent's immunizations.In the past decade, the adolescent immunization schedule has expanded to include 2 doses of quadrivalent meningococcal conjugate vaccine, 1 dose of tetanus, diphtheria, acellular pertussis, absorbed vaccine, 2 or 3 doses of human papillomavirus vaccine, depending on the child's age, and an annual influenza vaccine...
February 6, 2017: Pediatrics
https://www.readbyqxmd.com/read/28154539/temporal-association-of-certain-neuropsychiatric-disorders-following-vaccination-of-children-and-adolescents-a-pilot-case-control-study
#6
Douglas L Leslie, Robert A Kobre, Brian J Richmand, Selin Aktan Guloksuz, James F Leckman
BACKGROUND: Although the association of the measles, mumps, and rubella vaccine with autism spectrum disorder has been convincingly disproven, the onset of certain brain-related autoimmune and inflammatory disorders has been found to be temporally associated with the antecedent administration of various vaccines. This study examines whether antecedent vaccinations are associated with increased incidence of obsessive-compulsive disorder (OCD), anorexia nervosa (AN), anxiety disorder, chronic tic disorder, attention deficit hyperactivity disorder, major depressive disorder, and bipolar disorder in a national sample of privately insured children...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28152472/exposure-to-phthalates-is-associated-with-lipid-profile-in-peripubertal-mexican-youth
#7
Wei Perng, Deborah J Watkins, Alejandra Cantoral, Adriana Mercado-García, John D Meeker, Martha Maria Téllez-Rojo, Karen E Peterson
Animal models indicate that endocrine disrupting chemicals (EDCs) affect circulating lipid concentrations by interfering with hepatic fatty acid oxidation. Little is known of the relationship between EDC exposure and lipid profile in humans. We measured bisphenol A (BPA) and 9 phthalate metabolites in maternal urine collected at up to three time points during pregnancy as a measure of in utero exposure, and in the child's urine at 8-14 years as a measure of concurrent, peripubertal exposure among 248 participants of a Mexico City pre-birth cohort...
January 30, 2017: Environmental Research
https://www.readbyqxmd.com/read/28138117/neuroleptic-malignant-syndrome-associated-with-valproate-in-an-adolescent
#8
Veli Yıldırım, Meltem Çobanogulları Direk, Serkan Güneş, Çetin Okuyaz, Fevziye Toros
Neuroleptic malignant syndrome (NMS) is a life-threatening idiosyncratic reaction that usually occurs after the administration of antipsychotic drugs. Antidepressants, benzodiazepines, and antiepileptic drugs are also suggested to be associated with NMS. It is believed to result from a dopaminergic blockade in the central nervous system. NMS is manifested by hyperthermia, muscle rigidity, autonomic dysfunction, altered mental status, leukocytosis, and elevated serum creatinine phosphokinase. Valproate is commonly used in the treatment of many psychiatric and neurologic disorders...
February 28, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28134742/will-infant-hepatitis-b-vaccination-protect-into-adulthood-extended-canadian-experience-after-a-2-4-6-month-immunization-schedule
#9
Michelle Pinto, Meena Dawar, Mel Krajden, Monika Naus, David W Scheifele
INTRODUCTION: Hepatitis B virus (HBV) vaccination programs generally target infants to prevent chronic HBV infection and/or pre-adolescents to reduce transmission in adulthood. To assess whether infant HBV immunization can potentially accomplish both objectives we measured residual immunity 10-16 years after vaccination in Canadian children. METHODS: A prospective, parallel group, single center study enrolled adolescents given HBV vaccine at 2, 4, and 6 months of age...
January 26, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28133957/efficacy-and-safety-of-vaccination-in-pediatric-patients-with-systemic-inflammatory-rheumatic-diseases-a-systematic-review-of-the-literature
#10
Sandra Sousa, Ana Catarina Duarte, Inês Cordeiro, Joana Ferreira, Maria João Gonçalves, Tiago Meirinhos, Teresa Martins Rocha, Vasco C Romão, Maria José Santos
INTRODUCTION: Children and adolescents with systemic rheumatic diseases have an increased risk of infections. Although some infections are vaccine-preventable, immunization among patients with juvenile rheumatic diseases is suboptimal, partly due to some doubts that still persist regarding its efficacy and safety in this patient population. OBJECTIVES: To review the available evidence regarding the immunological response and the safety of vaccination in children and adolescents with systemic inflammatory rheumatic diseases (SIRD)...
November 9, 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28133615/pregnancy-during-adolescence-and-associated-risks-an-8-year-hospital-based-cohort-study-2007-2014-in-romania-the-country-with-the-highest-rate-of-teenage-pregnancy-in-europe
#11
Demetra-Gabriela Socolov, Magdalena Iorga, Alexandru Carauleanu, Ciprian Ilea, Iolanda Blidaru, Lucian Boiculese, Razvan-Vladimir Socolov
Aim. To determine pregnancy and delivery outcomes among teenagers. Materials and Methods. An 8-year retrospective comparative hospital-based cohort study is analysing singleton pregnancy comorbidities and delivery parameters of a teenage group under the age of 20 compared with a young adult group 20-24 years of age in a university hospital. Results. Teenage is a risk factor for preterm birth <37 weeks (1.21 [1.08-1.35]), foetal growth restriction (1.34 [1.21-1.48]), episiotomy (1.27 [1.21-1.34]), uterine revision (1...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28112049/kidney-disease-in-hepatitis-b-surface-antigen-positive-children-experience-from-a-centre-in-south-west-nigeria-and-a-review-of-the-nigerian-literature
#12
Adanze O Asinobi, Adebowale D Ademola, Clement A Okolo, Adedayo A Adepoju, Susan M Samuel, Wendy E Hoy
BACKGROUND: Kidney disease is an important extra-hepatic manifestation of hepatitis B virus (HBV) infection. However, there is paucity of recent literature on kidney disease in children and adolescents with HBV infection from several parts of sub-Saharan Africa including Nigeria. OBJECTIVE: To review the pattern of kidney disease in hepatitis B surface antigen (HBsAg)-positive children and adolescents seen at a tertiary hospital in south-west Nigeria. METHODS: A retrospective study was undertaken of HBsAg-seropositive children with kidney disease managed at University College Hospital, Ibadan, from January 2004 to December 2015...
January 23, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28102704/thimerosal-exposure-and-disturbance-of-emotions-specific-to-childhood-and-adolescence-a-case-control-study-in-the-vaccine-safety-datalink-vsd-database
#13
David A Geier, Janet K Kern, Kristin G Homme, Mark R Geier
BACKGROUND: This study evaluated Thimerosal-containing childhood vaccines and the risk of a diagnosis called disturbance of emotions specific to childhood and adolescence (ED). Thimerosal is an organic-mercury (Hg)-containing compound used in some vaccines. METHODS: A hypothesis-testing prospective, longitudinal case-control study evaluated Hg exposure from Thimerosal in hepatitis B vaccines administered at specific times within the first 6 months of life and its association with medically diagnosed ED (313...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28097080/immunoglobulin-m-nephropathy-in-a-patient-with-wilson-s-disease
#14
Zain Ul Abideen, Zoya Sajjad, Asna Haroon Khan, Nadira Mamoon, Muhammad Bilal, Khaja Hameeduddin Mujtaba Quadri
Immunoglobulin M nephropathy (IgMN) is characterized by the deposition of immunoglobulin M in a dominant distribution in the renal glomeruli. Primary immunoglobulin M nephropathy is diagnosed after consistent light microscopy (LM), immunofluorescence (IF), electron microscopy (EM) results, and exclusion of known systemic disorders causing immunoglobulin M deposition in the glomeruli. The secondary disease has been reported with a few conditions though it has never been reported with any primary disease of the liver...
December 13, 2016: Curēus
https://www.readbyqxmd.com/read/28090342/-1-h-mrs-measured-ectopic-fat-in-liver-and-muscle-is-associated-with-the-metabolic-syndrome-in-danish-girls-but-not-in-boys-with-overweight-and-obesity
#15
A Nissen, C E Fonvig, E Chabanova, C Bøjsøe, C Trier, O Pedersen, T Hansen, H S Thomsen, J-C Holm
BACKGROUND: The metabolic syndrome (MetS) is a complication to overweight and obesity, which can be observed already in childhood. Ectopic lipid accumulation in muscle and liver has been shown to associate with the development of insulin resistance and dyslipidemia. Thus, the interaction between MetS and ectopic fat may offer clinical relevance. OBJECTIVES: To investigate the prevalence of MetS, or components hereof, and ectopic fat accumulation in liver and skeletal muscle tissue in children, as well as interactions between these...
December 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/28069363/adolescent-booster-with-hepatitis-b-virus-vaccines-decreases-hbv-infection-in-high-risk-adults
#16
Yuting Wang, Taoyang Chen, Ling-Ling Lu, Minjie Wang, Dongmei Wang, Hongyu Yao, Chunsun Fan, Jun Qi, Yawei Zhang, Chunfeng Qu
BACKGROUND: Neutralizing antibodies (anti-HBs) after immunization with hepatitis B virus (HBV) vaccines against HBV surface antigen (HBsAg) wane after 10-15years. We analyzed the effect of an adolescent booster given to vaccination-protected children born to mothers with different HBsAg-carrying status against HBV infection in their mature adulthood. METHODS: A total of 9793 individuals, who were HBsAg-negative at childhood (baseline) and donated blood samples, both during childhood and adulthood, from the vaccination group in "Qidong Hepatitis B Intervention Study", were enrolled...
February 15, 2017: Vaccine
https://www.readbyqxmd.com/read/28056844/hepatitis-e-virus-seroprevalence-among-the-general-population-in-a-livestock-dense-area-in-the-netherlands-a-cross-sectional-population-based-serological-survey
#17
Arianne B van Gageldonk-Lafeber, Wim van der Hoek, Floor Borlée, Dick J J Heederik, Sofie H Mooi, Catharina B M Maassen, C Joris Yzermans, Barry Rockx, Lidwien A M Smit, Johan H J Reimerink
BACKGROUND: Recent serological studies indicate that hepatitis E virus (HEV) is endemic in industrialised countries. The increasing trend in the number of autochthonous cases of HEV genotype 3 in Western European countries, stresses the importance to get insight in the exact routes of exposure. Pigs are the main animal reservoir, and zoonotic food-borne transmission of HEV is proven. However, infected pigs can excrete large amounts of virus via their faeces enabling environmental transmission of HEV to humans...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28049229/tandem-high-dose-chemotherapy-and-autologous-stem-cell-transplantation-for-high-grade-gliomas-in-children-and-adolescents
#18
Ji Won Lee, Do Hoon Lim, Ki Woong Sung, Hyeong Jin Lee, Eun Sang Yi, Keon Hee Yoo, Hong Hoe Koo, Yeon Lim Suh, Hyung Jin Shin
With the aim to investigate the outcome of tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT) for high-grade gliomas (HGGs), we retrospectively reviewed the medical records of 30 patients with HGGs (16 glioblastomas, 7 anaplastic astrocytomas, and 7 other HGGs) between 2006 and 2015. Gross or near total resection was possible in 11 patients. Front-line treatment after surgery was radiotherapy (RT) in 14 patients and chemotherapy in the remaining 16 patients including 3 patients less than 3 years of age...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28040302/omega-3-fatty-acids-as-a-treatment-for-non-alcoholic-fatty-liver-disease-in-children-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#19
Lian-Hui Chen, Yong-Fen Wang, Qing-Hong Xu, Shan-Shan Chen
BACKGROUND: The most typical chronic liver disease in children and adolescents is non-alcoholic fatty liver disease (NAFLD). The dietary addition of ω-3 polyunsaturated fatty acids (PUFAs) provides a promising therapy for children with NAFLD due to its convenience and safety; however, several studies suggested contradictory results for PUFA supplementation in children. Hence, we performed a systematic review and meta-analysis to evaluate the effectiveness of PUFA supplementation in children with NAFLD...
December 23, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28024920/hepatic-adenomas-in-adolescents-and-young-women-with-endometriosis-treated-with-norethindrone-acetate
#20
P C Brady, S A Missmer, M R Laufer
BACKGROUND: Endometriosis-ectopic implantation of endometrial-like tissue-affects 10% of female adolescents and adults. First-line treatment includes progesterone-only (such as norethindrone acetate, NET-A) or combined estrogen/progestin oral contraceptive pills. Estrogen-containing contraceptives confer increased risk of hepatic adenomas, while the association with NET-A is very rarely reported. CASE: Three adolescents with Stage I-II endometriosis managed with NET-A (up to 15 mg/day for 28-78 months) were diagnosed with hepatic adenomas at ages 17-22 years...
December 23, 2016: Journal of Pediatric and Adolescent Gynecology
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