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https://www.readbyqxmd.com/read/29234924/a-new-direction-in-anastomotic-research-should-we-redesign-the-angle-of-sorrow
#1
Omar E Aly
INTRODUCTION: Despite advances in oncological outcomes in colo-rectal surgery, rates of anastomotic leak have not improved. The precise mechanisms of anastomotic leak remain poorly understood. Current research has focused on anastomotic reinforcement to tackle anastomotic leak with little success. The 'Angle of Sorrow', the corner of the anastomosis is prone to anastomotic leak, but remains a persistent feature in the gastrointestinal anastomosis. The tendency for stress forces to concentrate in the vulnerable 'Angle of Sorrow' prompts the need for anastomotic design research...
December 12, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29234738/redesigning-axial-axial-biaxial-cruciform-specimens-for-very-high-cycle-fatigue-ultrasonic-testing-machines
#2
Diogo Montalvão, Andrew Wren
The necessity to increase performances in terms of lifetime and security in mechanical components or structures is the motivation for intense research in fatigue. Applications range from aeronautics to medical devices. With the development of new materials, there is no longer a fatigue limit in the classical sense, where it was accepted that the fatigue limit is the stress level such that there is no fracture up to 1E7 cycles. The recent development of ultrasonic testing machines where frequencies can go as high as 20 kHz or over enabled tests to be extended to ranges larger than 1E9 in just a few days...
November 2017: Heliyon
https://www.readbyqxmd.com/read/29233529/innovating-patient-care-delivery-dsrip-s-interrupted-time-series-analysis-paradigm
#3
Amrita G Shenoy, Charles E Begley, Lee Revere, Stephen H Linder, Stephen P Daiger
INTRODUCTION: Adoption of Medicaid Section 1115 waiver is one of the many ways of innovating healthcare delivery system. The Delivery System Reform Incentive Payment (DSRIP) pool, one of the two funding pools of the waiver has four categories viz. infrastructure development, program innovation and redesign, quality improvement reporting and lastly, bringing about population health improvement. BACKGROUND: A metric of the fourth category, preventable hospitalization (PH) rate was analyzed in the context of eight conditions for two time periods, pre-reporting years (2010-2012) and post-reporting years (2013-2015) for two hospital cohorts, DSRIP participating and non-participating hospitals...
December 7, 2017: Healthcare
https://www.readbyqxmd.com/read/29233137/rational-modification-of-substrate-binding-site-by-structure-based-engineering-of-a-cellobiose-2-epimerase-in-caldicellulosiruptor-saccharolyticus
#4
Ah-Reum Park, Jin-Sook Kim, Seung-Won Jang, Young-Gyun Park, Bong-Seong Koo, Hyeon-Cheol Lee
BACKGROUND: Lactulose, a synthetic disaccharide, has received increasing interest due to its role as a prebiotic, specifically proliferating Bifidobacilli and Lactobacilli and enhancing absorption of calcium and magnesium. The use of cellobiose 2-epimerase (CE) is considered an interesting alternative for industrial production of lactulose. CE reversibly converts D-glucose residues into D-mannose residues at the reducing end of unmodified β-1,4-linked oligosaccharides, including β-1,4-mannobiose, cellobiose, and lactose...
December 12, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29224641/design-of-a-bilevel-clinical-trial-targeting-adherence-in-heart-failure-patients-and-their-providers-the-congestive-heart-failure-adherence-redesign-trial-chart
#5
Ashvarya Mangla, Rami Doukky, DeJuran Richardson, Elizabeth F Avery, Rebecca Dawar, James E Calvin, Lynda H Powell
BACKGROUND: Socioeconomically disadvantaged patients are at an increased risk for adverse heart failure (HF) outcomes based upon nonadherence to medications and diet. Physicians are also suboptimally adherent to prescribing evidence-based therapy for HF. METHODS: Congestive Heart Failure Adherence Redesign Trial (CHART) (NCT01698242) is a multicenter, bilevel, cluster randomized behavioral efficacy trial designed to assess the impact of intervening simultaneously on physicians and their socioeconomically disadvantaged patients (annual income <$30,000) having HF with reduced ejection fraction...
January 2018: American Heart Journal
https://www.readbyqxmd.com/read/29222806/identification-of-udp-glucose-binding-site-in-glycosyltransferase-domain-of-sucrose-phosphate-synthase-from-sugarcane-saccharum-officinarum-by-structure-based-site-directed-mutagenesis
#6
REVIEW
Widhi Dyah Sawitri, Siti Nurul Afidah, Atsushi Nakagawa, Toshiharu Hase, Bambang Sugiharto
Sucrose phosphate synthase (SPS) is believed to be the key enzyme for controlling the biosynthesis of sucrose. SPSs consist of a functional glycosyltransferase domain that shares conserved residues with the glycosyltransferase domain of sucrose biosynthesis-related protein. The formation of sucrose-6-phosphate is catalyzed by SPS with the transfer of a glycosyl group of uridine diphosphate glucose (UDP-G) as an activated donor sugar to a fructose-6-phosphate as a sugar acceptor. However, understanding of the mechanism of catalytic and substrate binding in SPS is very limited...
December 8, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/29218629/design-of-artificial-metalloproteins-metalloenzymes-by-tuning-noncovalent-interactions
#7
REVIEW
Shun Hirota, Ying-Wu Lin
Noncovalent weak interactions [hydrophobic interaction and hydrogen (H)-bond] play crucial roles in controlling the functions of biomolecules, and thus have been used to design artificial metalloproteins/metalloenzymes during the past few decades. In this review, we focus on the recent progresses in protein design by tuning the noncovalent interactions, including hydrophobic and H-bonding interactions. The topics include redesign and reuse of the heme pocket and other protein scaffolds, design of the heme protein interface, and de novo design of metalloproteins...
December 7, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29197264/blended-learning-pedagogy-designed-for-communication-module-among-undergraduate-nursing-students-a-quasi-experimental-study
#8
Shefaly Shorey, Yanika Kowitlawakul, M Kamala Devi, Hui-Chen Chen, Swee Kit Alan Soong, Emily Ang
BACKGROUND: Effective communication is important for nurse and patient outcomes. Nursing students often feel unprepared to communicate effectively with patients and other healthcare workers within the clinical environment. Blended learning pedagogy-based communication skills training can provide an alternative to traditional methods of teaching to enhance students' satisfaction and self-efficacy levels in communicating with others. OBJECTIVES: To examine the effectiveness of blended learning pedagogy in a redesigned communication module among nursing undergraduates in enhancing their satisfaction levels and attitudes towards learning communication module as well as self-efficacy in communication...
November 16, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29196634/rational-engineering-of-a-native-hyperthermostable-lactonase-into-a-broad-spectrum-phosphotriesterase
#9
Pauline Jacquet, Julien Hiblot, David Daudé, Céline Bergonzi, Guillaume Gotthard, Nicholas Armstrong, Eric Chabrière, Mikael Elias
The redesign of enzyme active sites to alter their function or specificity is a difficult yet appealing challenge. Here we used a structure-based design approach to engineer the lactonase SsoPox from Sulfolobus solfataricus into a phosphotriesterase. The five best variants were characterized and their structure was solved. The most active variant, αsD6 (V27A-Y97W-L228M-W263M) demonstrates a large increase in catalytic efficiencies over the wild-type enzyme, with increases of 2,210-fold, 163-fold, 58-fold, 16-fold against methyl-parathion, malathion, ethyl-paraoxon, and methyl-paraoxon, respectively...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29196330/dental-students-study-habits-in-flipped-blended-classrooms-and-their-association-with-active-learning-practices
#10
Cynthia C Gadbury-Amyot, Gloria J Redford, Brenda S Bohaty
In recognition of the importance for dental education programs to take a student-centered approach in which students are encouraged to take responsibility for their learning, a pediatric dentistry course redesign aimed at promoting greater active and self-directed learning was implemented at one U.S. dental school. The aim of this study was to examine the association between the students' self-reported study habits and active learning practices necessary for meaningful learning in the flipped/blended classroom...
December 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/29196271/gibson-assembly-facilitates-bacterial-allelic-exchange-mutagenesis
#11
Oleksandra Silayeva, Andrew C Barnes
Allelic exchange mutagenesis that relies on RecA-mediated homologous recombination up- and downstream from the targeted gene is a generalizable method of site-specific bacterial gene knock-out and knock-in. However, generation of a mutagenic DNA construct (alternative allele flanked by regions surrounding the gene target) and subsequent mutant selection are laborious procedures. Here we demonstrate allelic exchange knock-out facilitated by Gibson Assembly in Streptococcus iniae. Gibson Assembly allows rapid construction of a mutagenic DNA sequence simultaneous with cloning, as well as rapid reconstruction of complete recombinant vector sequence when required...
November 28, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29190535/experiences-of-nursing-undergraduates-on-a-redesigned-blended-communication-module-a-descriptive-qualitative-study
#12
Shefaly Shorey, An Ling Siew, Emily Ang
BACKGROUND: Education is going through accelerated changes to accommodate the needs of contemporary students. However, there are ongoing concerns regarding the quality of education in communication skills for nurses and other healthcare professionals. Many studies have been conducted to evaluate the effectiveness of a blended learning pedagogical tool in enhancing the learning of nursing undergraduates. However, little is known about students' experiences of a blended learning model for teaching communication skills...
November 15, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29190443/corrigendum-to-it-s-more-than-money-policy-options-to-secure-medical-specialist-workforce-for-regional-centres
#13
Jennifer May, Judi Walker, Mathew McGrail, Fran Rolley
Objectives Regional centres and their rural hinterlands support significant populations of non-metropolitan Australians. Despite their importance in the settlement hierarchy and the key medical services provided from these centres, little research has focused on their issues of workforce supply and long-term service requirements. In addition, they are a critical component of the recent growth of 'regional' hub-and-spoke specialist models of service delivery.Methods The present study interviewed 62 resident specialists in four regional centres, seeking to explore recruitment and retention factors important to their location decision making...
December 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29189491/project-echo-a-telementoring-network-model-for-continuing-professional-development
#14
Sanjeev Arora, Summers G Kalishman, Karla A Thornton, Miriam S Komaromy, Joanna G Katzman, Bruce B Struminger, William F Rayburn
INTRODUCTION: A major challenge with current systems of CME is the inability to translate the explosive growth in health care knowledge into daily practice. Project ECHO (Extension for Community Healthcare Outcomes) is a telementoring network designed for continuing professional development (CPD) and improving patient outcomes. The purpose of this article was to describe how the model has complied with recommendations from several authoritative reports about redesigning and enhancing CPD...
November 15, 2017: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/29189476/pursuit-of-value-drives-strategy-to-improve-operations-and-outcomes
#15
Marna P Borgstrom, Ohm M Deshpande, Thomas J Balcezak
The future of American healthcare remains cloudy, with the shifting contours of regulatory and fiscal reform still being shaped. Providers are beset by many challenges that vary but often include state and federal healthcare funding decisions that are antithetical to the interests of patients and aging populations. Regional public health crises and rapidly evolving relationships with third-party payers complicate matters even further.Yale New Haven Health System decided to pursue value as its overriding strategy for navigating the uncertainty in healthcare that is likely to persist for years to come...
January 2017: Frontiers of Health Services Management
https://www.readbyqxmd.com/read/29188455/the-role-of-cardiologists-in-the-management-of-patients-with-heart-failure
#16
Vera Maria Avaldi, Jacopo Lenzi
Heart failure is a complex clinical syndrome with a remarkable impact on health care systems in terms of patients' morbidity and mortality, as well as direct and indirect costs. It is essential to redesign models of care for patients with heart failure that are tailored on personalized health care needs and carried out in the most appropriate setting. There is some debate about the role of cardiologists in the management of patients with heart failure. Indeed, results regarding the inclination of cardiologists' patients to achieve better outcomes are controversial, given the heterogeneity of studies in terms of study design, population, setting and variables considered...
November 30, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29187165/imagej2-imagej-for-the-next-generation-of-scientific-image-data
#17
Curtis T Rueden, Johannes Schindelin, Mark C Hiner, Barry E DeZonia, Alison E Walter, Ellen T Arena, Kevin W Eliceiri
BACKGROUND: ImageJ is an image analysis program extensively used in the biological sciences and beyond. Due to its ease of use, recordable macro language, and extensible plug-in architecture, ImageJ enjoys contributions from non-programmers, amateur programmers, and professional developers alike. Enabling such a diversity of contributors has resulted in a large community that spans the biological and physical sciences. However, a rapidly growing user base, diverging plugin suites, and technical limitations have revealed a clear need for a concerted software engineering effort to support emerging imaging paradigms, to ensure the software's ability to handle the requirements of modern science...
November 29, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29183921/diagnostic-immunohistochemistry-in-gynaecological-neoplasia-a-brief-survey-of-the-most-common-scenarios
#18
Elisabetta Kuhn, Ayse Ayhan
Immunohistochemistry is a valuable adjunct in routine gynaecological pathology. The molecular revolution has redesigned knowledge of gynaecological cancers and refined histological classification. The direct consequence has been the progressive introduction of new immunostainings for diagnostic and classification purposes. Hence, we review the routine diagnostic use of immunohistochemistry in the field of gynaecological neoplasia. We reviewed the immunomarkers useful in gynaecological pathology according to literature revision, our personal experience and research findings...
November 28, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29180550/information-transfer-and-the-hospital-discharge-summary-national-primary-care-provider-perspectives-of-challenges-and-opportunities
#19
Paul M Robelia, Deanne T Kashiwagi, Sarah M Jenkins, James S Newman, Atsushi Sorita
PURPOSE: The hospital discharge summary (HDS) serves as a critical method of patient information transfer between hospitalist and primary care provider (PCP). This study was designed to increase our understanding of PCP preferences for, and perceived deficiencies in, the discharge summary. METHODS: We designed a mail survey that was sent to a random sample of 800 American Academy of Family Physicians members nationally. The survey response rate was 59%. We analyzed the availability of summaries at hospital followup, whether all desired information was contained in the summary and whether certain specific items were completed...
November 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29175726/the-redesigned-forensic-research-reference-on-genetics-knowledge-base-frog-kb
#20
Kenneth K Kidd, Usha Soundararajan, Haseena Rajeevan, Andrew J Pakstis, Katherine N Moore, Jeri D Ropero-Miller
The Forensic Resource/Reference on Genetics-knowledge base (FROG-kb) web site <https://frog.med.yale.edu/FrogKB/> was introduced in 2011 and in the five years since the previous publication ongoing research into how the database can better serve forensics has resulted in extensive redesign of the database interface and functionality. Originally designed as a prototype to support forensic use of single nucleotide polymorphisms (SNPs), FROG-kb provides a freely accessible web interface that facilitates forensic practice and can be useful for teaching and research...
November 14, 2017: Forensic Science International. Genetics
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