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https://www.readbyqxmd.com/read/28530103/redesign-of-a-pyrylium-photoredox-catalyst-and-its-application-to-the-generation-of-carbonyl-ylides
#1
Edwin Alfonzo, Felix Steven Alfonso, Aaron B Beeler
We report the exploration into photoredox generation of carbonyl ylides from benzylic epoxides using newly designed 4-mesityl-2,6-diphenylpyrylium tetrafluoroborate (MDPT) and 4-mesityl-2,6-di-p-tolylpyrylium tetrafluoroborate (MD(p-tolyl)PT) catalysts. These catalysts are excited at visible wavelengths, are highly robust, and exhibit some of the highest oxidation potentials reported. Their utility was demonstrated in the mild and efficient generation of carbonyl ylides from benzylic epoxides that otherwise could not be carried out by current common photoredox catalysts...
May 22, 2017: Organic Letters
https://www.readbyqxmd.com/read/28528627/physical-risk-factors-identification-based-on-body-sensor-network-combined-to-videotaping
#2
Nicolas Vignais, Fabien Bernard, Gérard Touvenot, Jean-Claude Sagot
The aim of this study was to perform an ergonomic analysis of a material handling task by combining a subtask video analysis and a RULA computation, implemented continuously through a motion capture system combining inertial sensors and electrogoniometers. Five workers participated to the experiment. Seven inertial measurement units, placed on the worker's upper body (pelvis, thorax, head, arms, forearms), were implemented through a biomechanical model of the upper body to continuously provide trunk, neck, shoulder and elbow joint angles...
May 18, 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28528621/using-lean-to-rapidly-and-sustainably-transform-a-behavioral-health-crisis-program-impact-on-throughput-and-safety
#3
Margaret E Balfour, Kathleen Tanner, Paul J Jurica, Dawn Llewellyn, Robert G Williamson, Chris A Carson
BACKGROUND: Lean has been increasingly applied in health care to reduce waste and improve quality, particularly in fast-paced and high-acuity clinical settings such as emergency departments. In addition, Lean's focus on engagement of frontline staff in problem solving can be a catalyst for organizational change. In this study, ConnectionsAZ demonstrates how they applied Lean principles to rapidly and sustainably transform clinical operations in a behavioral health crisis facility. METHODS: A multidisciplinary team of management and frontline staff defined values-based outcome measures, mapped the current and ideal processes, and developed new processes to achieve the ideal...
June 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28527501/clinical-decision-support-and-the-electronic-health-record-applications-for-physiatry
#4
REVIEW
Joel S Shoolin
Clinical decision support (CDS) is a process that provides information to assist the user in decision making for evaluation and treatment. Although many think only of rules and alerts, CDS is much more than that. Order sets, clinical documents, information fields, and medication sentences are just a few other CDS tools to be considered. CDS has been shown to improve care. Forming the third point of the triangle, CDS, along with process redesign and workflow considerations, improves care and helps create successful outcomes...
May 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28525672/testing-of-a-novel-percutaneous-temporary-aortic-valve-in-a-rabbit-model-of-acute-severe-aortic-regurgitation-an-experimental-study
#5
Paul C Ho
PURPOSE: Device management of hemodynamic instability due to acute aortic regurgitation is not available. A novel, catheter-based, temporary aortic valve (TAV) has been in development. Early prototypes (balloon-based TAV) have undergone proof-of-concept studies in mathematical, bench and animal models. The redesigned membrane-based TAV prototype is evaluated in a rabbit model of acute severe aortic regurgitation. METHODS: Acute aortic regurgitation was simulated by deploying a self-expanding endovascular stent across the aortic annulus...
May 18, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28525279/double-winged-3-hydroxypyrimidine-2-4-diones-potent-and-selective-inhibition-against-hiv-1-rnase-h-with-significant-antiviral-activity
#6
Sanjeev Kumar V Vernekar, Jing Tang, Bulan Wu, Andrew D Huber, Mary C Casey, Nataliya S Myshakina, Daniel J Wilson, Jayakanth Kankanala, Karen A Kirby, Michael A Parniak, Stefan G Sarafianos, Zhengqiang Wang
Human immunodeficiency virus (HIV) reverse transcriptase (RT)-associated ribonuclease H (RNase H) remains the only virally encoded enzymatic function yet to be exploited as an antiviral target. One of the possible challenges may be that targeting HIV RNase H is confronted with a steep substrate barrier. We have previously reported a 3-hydroxypyrimidine-2,4-dione (HPD) subtype that potently and selectively inhibited RNase H without inhibiting HIV in cell culture. We report herein a critical redesign of the HPD chemotype featuring an additional wing at the C5 position that led to drastically improved RNase H inhibition and significant antiviral activity...
May 19, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28524876/self-assembly-of-a-supramolecular-hexagram-and-a-supramolecular-pentagram
#7
Zhilong Jiang, Yiming Li, Ming Wang, Bo Song, Kun Wang, Mingyu Sun, Die Liu, Xiaohong Li, Jie Yuan, Mingzhao Chen, Yuan Guo, Xiaoyu Yang, Tong Zhang, Charles N Moorefield, George R Newkome, Bingqian Xu, Xiaopeng Li, Pingshan Wang
Five- and six-pointed star structures occur frequently in nature as flowers, snow-flakes, leaves and so on. These star-shaped patterns are also frequently used in both functional and artistic man-made architectures. Here following a stepwise synthesis and self-assembly approach, pentagonal and hexagonal metallosupramolecules possessing star-shaped motifs were prepared based on the careful design of metallo-organic ligands (MOLs). In the MOL design and preparation, robust ruthenium-terpyridyl complexes were employed to construct brominated metallo-organic intermediates, followed by a Suzuki coupling reaction to achieve the required ensemble...
May 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28524269/paradoxical-perceptions-towards-the-introduction-of-assistants-in-speech-language-pathology-and-potential-impact-on-consumers
#8
Rachael O'Brien, Rebecca Mitchell, Nicole Byrne
RATIONALE AND AIM: Working with assistants has the potential to be an economically and professionally sustainable solution to workforce shortages in speech-language pathology. However, there is some resistance to the workforce redesign, and factors that determine how assistants are utilised are not well understood. The aim of this study was to understand the perceptions that engender professional resistance and identify factors that may lessen such resistance. METHOD: Semi-structured interviews were conducted with 20 speech-language pathologists (SLPs) to learn about perceptions towards implementing assistants into the profession...
May 19, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28523654/a-ph-switch-for-%C3%AE-sheet-protein-folding
#9
Jordan M Anderson, Niels H Andersen
Protein design advancements have led to biotechnological strategies based on more stable and more specific structures. Herein we present a 6-residue sequence (HPATGK) that acts as a stable structure-nucleating turn at physiological and higher pH but is notably unfavorable for chain direction reversal at low pH. When placed into the turn of a β-sheet, this leads to a pH switch of folding. Using a standard 3-stranded β-sheet model, the WW domain, it was found that the pH switch sequence insertion caused minimal change at pH 8 but a ca...
May 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28515181/measuring-ability-to-assess-claims-about-treatment-effects-the-development-of-the-claim-evaluation-tools
#10
Astrid Austvoll-Dahlgren, Daniel Semakula, Allen Nsangi, Andrew David Oxman, Iain Chalmers, Sarah Rosenbaum, Øystein Guttersrud
OBJECTIVES: To describe the development of the Claim Evaluation Tools, a set of flexible items to measure people's ability to assess claims about treatment effects. SETTING: Methodologists and members of the community (including children) in Uganda, Rwanda, Kenya, Norway, the UK and Australia. PARTICIPANTS: In the iterative development of the items, we used purposeful sampling of people with training in research methodology, such as teachers of evidence-based medicine, as well as patients and members of the public from low-income and high-income countries...
May 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28509719/the-importance-of-factors-related-to-nurse-retention-using-the-baptist-health-nurse-retention-questionnaire-part-2
#11
Andrew Bugajski, Alex Lengerich, Matthew Marchese, Brittany Hall, Susan Yackzan, Claire Davies, Dorothy Brockopp
OBJECTIVE: The purpose of this study was to examine the importance of factors related to nurse retention. BACKGROUND: Retaining nurses within the healthcare system is a challenge for hospital administrators. Understanding factors important to nurse retention is essential. METHODS: Responses of nurses (n = 279) to the Baptist Health Nurse Retention Questionnaire (BHNRQ) at a 391-bed Magnet® redesignated community hospital were analyzed to explore differences in importance scores of bedside nurses...
May 15, 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28508794/on-the-prototyping-of-an-ict-enhanced-toilet-system-for-assisting-older-persons-living-independently-and-safely-at-home
#12
Paul Panek, Gabor Fazekas, Theresa Lüftenegger, Peter Mayer, Tamas Pilissy, Matteo Raffaelli, Atilla Rist, Ramona Rosenthal, Arso Savanovic, Anna Sobjak, Franziska Sonntag, Andras Toth, Birgit Unger
Standard toilets often do not meet the needs of a significant number of older persons and persons with disabilities. The EU funded iToilet project aims at design and development of a new type of ICT enhanced modular toilet system which shall be able to support autonomy, dignity and safety of older persons living at home. Methodologically the project started with gathering user requirements by means of questionnaires, interviews and focus group discussion involving a total of 74 persons, thereof 41 subjects with movement disorders (primary users), 21 caregivers (secondary users) and 12 healthcare managers (tertiary users)...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28503857/recent-developments-in-structural-studies-on-acetylcholinesterase
#13
REVIEW
Israel Silman, Joel L Sussman
This review focuses on several recent developments concerning structure-function relationships in vertebrate acetylcholinesterase. These include studies on high-resolution structures of human acetylcholinesterase and its complexes; the first crystal structure of a snake venom acetylcholinesterase, in which open and closed states of the 'back door' are visualized; a powerful algorithm for redesigning proteins for enhanced expression in prokaryotic systems, as applied to human acetylcholinesterase, which has hitherto been an intractable target; in situ implementation of 'click chemistry' in crystalline acetylcholinesterase, which yields novel insights into the steric and dynamic changes involved in the reaction within the active-site gorge; and a study that demonstrates the effect of crystallization conditions on ligand alignment within a protein complex, in this case the methylene blue-Torpedo californica acetylcholinesterase complex, which highlights the relevance of the precipitant employed to structure-based drug design...
May 15, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28501195/recycling-polymer-residues-to-synthesize-magnetic-nanocomposites-for-dispersive-micro-solid-phase-extraction
#14
Hoda Ghambari, Emilia M Reyes-Gallardo, Rafael Lucena, Mohammad Saraji, Soledad Cárdenas
The ubiquitous presence of plastics, an obvious consequence of their usefulness and low price, has turned them into a problem of environmental and safety concern. The new plastic economy, an initiative recently launched by the World Economic Forum and Ellen MacArthur Foundation, with analytical support from McKinsey & Company, promotes a change in the use of plastic worldwide around three main pillars: redesign, reusing and recycling. Recycled plastics, with the aim of extending their life spam, can be used to synthesize materials for analytical purposes...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28501117/institutional-variation-in-surgical-care-for-early-stage-breast-cancer-at-community-hospitals
#15
Christopher M Dodgion, Stuart R Lipsitz, Marquita R Decker, Yue-Yung Hu, Sudha R Pavuluri Quamme, Anita Karcz, Leonard D'Avolio, Caprice C Greenberg
BACKGROUND: There is significant institutional variation in the surgical care of breast cancer, and this may reflect access to services and resultant physician practice patterns. In previous studies, specialty care has been associated with variation in the operative treatment of breast cancer but has not been evaluated in a community setting. This study investigates these issues in a cohort of 59 community hospitals in the United States. MATERIALS AND METHODS: Data on patients receiving an operation for breast cancer (2006-2009) in a large, geographically diverse cohort of hospitals were obtained...
May 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28494162/are-automatic-systems-the-future-of-motorcycle-safety-a-novel-methodology-to-prioritize-potential-safety-solutions-based-on-their-projected-effectiveness
#16
Gustavo Gil, Giovanni Savino, Simone Piantini, Niccolò Baldanzini, Riender Happee, Marco Pierini
OBJECTIVE: Motorcycle riders are involved in significantly more crashes per kilometer driven than passenger car drivers. Nonetheless, the development and implementation of motorcycle safety systems lags far behind that of passenger cars. This research addresses the identification of the most effective motorcycle safety solutions in the context of different countries. METHODS: A Knowledge-Based system of Motorcycle Safety (KBMS) was developed to assess the potential for various safety solutions to mitigate or avoid motorcycle crashes...
May 11, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28488991/geriatric-hip-fracture-care-fixing-a-fragmented-system
#17
Mary E Anderson, Kelly Mcdevitt, Ethan Cumbler, Heather Bennett, Zachary Robison, Bryan Gomez, Jason W Stoneback
CONTEXT: Fragmentation in geriatric hip fracture care is a growing concern because of the aging population. Patients with hip fractures at our institution historically were admitted to multiple different services and units, leading to unnecessary variation in inpatient care. Such inconsistency contributed to delays in surgery, discharge, and functional recovery; hospital-acquired complications; failure to adhere to best practices in osteoporosis management; and poor coordination with outpatient practitioners...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28488115/redesign-of-antifungal-polyene-glycosylation-engineered-biosynthesis-of-disaccharide-modified-npp
#18
Hye-Jin Kim, Seung-Hoon Kang, Si-Sun Choi, Eung-Soo Kim
Polyene macrolides such as nystatin A1 and amphotericin B have been known to be potent antifungal antibiotics for several decades. Because the therapeutic application of polyenes is restricted by severe side effects such as nephrotoxicity, various chemical and biological studies to modify the polyene structure have been conducted to develop less-toxic polyene antifungals. A newly discovered nystatin-like polyene compound NPP was shown to contain an aglycone that was identical to nystatin but harbored a unique di-sugar moiety, mycosaminyl-N-acetyl-glucosamine, which led to higher solubility and reduced hemolytic toxicity...
May 9, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28487459/patient-flow-within-uk-emergency-departments-a-systematic-review-of-the-use-of-computer-simulation-modelling-methods
#19
Syed Mohiuddin, John Busby, Jelena Savović, Alison Richards, Kate Northstone, William Hollingworth, Jenny L Donovan, Christos Vasilakis
OBJECTIVES: Overcrowding in the emergency department (ED) is common in the UK as in other countries worldwide. Computer simulation is one approach used for understanding the causes of ED overcrowding and assessing the likely impact of changes to the delivery of emergency care. However, little is known about the usefulness of computer simulation for analysis of ED patient flow. We undertook a systematic review to investigate the different computer simulation methods and their contribution for analysis of patient flow within EDs in the UK...
May 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28487427/structural-basis-for-linezolid-binding-site-rearrangement-in-the-staphylococcus-aureus-ribosome
#20
Matthew J Belousoff, Zohar Eyal, Mazdak Radjainia, Tofayel Ahmed, Rebecca S Bamert, Donna Matzov, Anat Bashan, Ella Zimmerman, Satabdi Mishra, David Cameron, Hans Elmlund, Anton Y Peleg, Shashi Bhushan, Trevor Lithgow, Ada Yonath
An unorthodox, surprising mechanism of resistance to the antibiotic linezolid was revealed by cryo-electron microscopy (cryo-EM) in the 70S ribosomes from a clinical isolate of Staphylococcus aureus This high-resolution structural information demonstrated that a single amino acid deletion in ribosomal protein uL3 confers linezolid resistance despite being located 24 Å away from the linezolid binding pocket in the peptidyl-transferase center. The mutation induces a cascade of allosteric structural rearrangements of the rRNA that ultimately results in the alteration of the antibiotic binding site...
May 9, 2017: MBio
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