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https://www.readbyqxmd.com/read/29778042/reliability-and-validity-of-the-dymus-questionnaire-for-the-assessment-of-dysphagia-in-multiple-sclerosis-greek-version-and-proposed-modification
#1
Athanasia Printza, Maria Kalaitzi, Christos Bakirtzis, Ioannis Nikolaidis, Hariklia Proios, Nikolaos Grigoriadis
BACKGROUND: Recent research confirmed that at least a third of people with multiple sclerosis (MS) are suffering from swallowing difficulties. Dysphagia is associated with significant morbidity and mortality, and has profound impact on physical ability and quality of life. Dysphagia related complications can be prevented through an effective screening protocol. The Dysphagia in Multiple Sclerosis (DYMUS) questionnaire is the first dysphagia questionnaire developed specifically for patients with MS...
May 10, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29778007/augmentation-of-the-expression-of-the-eotaxin-receptor-on-duodenal-neutrophils-by-il-21
#2
Yuji Takeda, Tomoyuki Kato, Nobuhito Nemoto, Akemi Araki, Mohammad Yeashin Gazi, Hidetoshi Nara, Hironobu Asao
Inflammation can occur via different mechanisms, such as via acute and chronic responses, on numerous occasions and function accordingly through various roles. There are more than five subsets of neutrophils; neutrophilic heterogeneity is modulated by the inflammatory condition. To understand the characteristics of inflammation, identification of atypical neutrophils is important. In this study, we found that the expression of eotaxin receptor (CD193) on atypical neutrophils in the duodenum is augmented in IL-21 isoform transgenic (Tg) mice...
May 16, 2018: Cytokine
https://www.readbyqxmd.com/read/29777979/a-qualitative-study-of-disengagement-in-disadvantaged-areas-of-the-uk-you-come-through-your-door-and-you-lock-that-door
#3
M Romeo-Velilla, N Ellis, G Hurst, S Grogan, C Gidlow
Health inequalities are a major concern in the UK. Power imbalances are associated with health inequalities and should be challenged through health promotion and empowering strategies, enabling individuals who feel powerless to take control over their own life and act on the determinants of health (Green and Tones, 2010). This study aimed to explore resident expectations of a community engagement programme that intended to empower communities to take action on pre-identified priorities. The programme targeted communities in deprived areas of a mid-sized city in the UK...
May 16, 2018: Health & Place
https://www.readbyqxmd.com/read/29777970/understanding-self-concealment-within-a-framework-of-eating-disorder-cognitions-and-body-image-flexibility-conceptual-and-applied-implications
#4
Akihiko Masuda, Janet D Latner, John P Barlie, Kayla Sargent
Although self-concealment has been long recognized in the context of body image disturbance and disordered eating concerns, empirical evidence remains limited. Following cognitive behavioral therapy (CBT) models of disordered eating and body image concerns, the present cross-sectional study examined whether the construct of self-concealment was related to disordered eating and body image concerns. More specifically, we investigated whether eating disorder cognitions and body image flexibility, two factors linked to the maintenance of disordered eating concerns, are uniquely associated with self-concealment, while controlling for key demographic and sociocultural variables...
May 16, 2018: Eating Behaviors
https://www.readbyqxmd.com/read/29777952/the-opportunity-to-avoid-pain-may-paradoxically-increase-fear
#5
Christine M van Vliet, Ann Meulders, Linda M G Vancleef, Johan W S Vlaeyen
Fear-avoidance models propose that pain-related fear may spur avoidance behaviour leading to chronic pain disability. Pain-related fear elicits avoidance behaviour, which is typically aimed at reducing fear. We hypothesized that engaging in avoidance may (paradoxically) increase rather than decrease pain-related fear (i.e. bidirectionality hypothesis). In a between-subject design, participants (N=64) were randomly assigned to the avoidance group or the control group. Avoidance group participants were led to believe they could avoid full exposure to a painful heat stimulus by pressing the stop-button, while control group participants believed they were exposed to the full painful heat stimulus at all times...
May 16, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29777927/patient-related-determinants-of-antibiotic-use-a-systematic-review
#6
REVIEW
V Zanichelli, G Tebano, I C Gyssens, V Vlahović-Palčevski, A A Monnier, M Stanic Benic, S Harbarth, M Hulscher, C Pulcini, B D Huttner
OBJECTIVES: We aimed to assess patient-related determinants potentially influencing antibiotic use. METHODS: Studies published in MEDLINE until 30/09/2015 were searched. We included: (1) qualitative studies describing patients' self-reported determinants of antibiotic use; (2) quantitative studies on either self-reported or objectively assessed determinants associated with antibiotic use. Whenever possible, reported determinants were categorized as "barriers" or "facilitators" of responsible antibiotic use...
May 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29777908/breast-cancer-in-the-gcc-countries-a-focus-on-brca1-2-and-non-brca1-2-genes
#7
REVIEW
Sumaya Rahman, Hatem Zayed
The GCC is an economic alliance of six Arab countries, including Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and United Arab Emirates (UAE). The rate of endogamous marriage among the GCC countries is approaching 100%, with very high consanguineous marriage rates. Although breast cancer is on the rise in the GCC countries, there are dearth of studies reporting on the genetic epidemiology of breast cancer. In this study, we investigated the frequency of BRCA1/2 and non-BRCA1/2 mutations in breast cancer patients in the GCC countries...
May 16, 2018: Gene
https://www.readbyqxmd.com/read/29777864/effectiveness-on-maternal-and-offspring-metabolic-control-of-a-home-based-dietary-counseling-intervention-and-dha-supplementation-in-obese-overweight-pregnant-women-might-study-a-randomized-controlled-trial-study-protocol
#8
María Luisa Garmendia, Camila Corvalán, Paola Casanello, B Marcela Araya, Marcela Flores, Alfredo Bravo, Juan Pedro Kusanovic, Pablo Olmos, Ricardo Uauy
BACKGROUND: Lifestyle interventions are the primary prevention strategy for gestational diabetes (GDM) in obese/overweight women; however, these interventions have shown limited effectiveness. Omega-3 polyunsaturated fatty acids (PUFAs) intake has shown beneficial effects on glucose metabolism, lipid fractions and inflammatory factors in women who already have GDM. Combining PUFAs supplementation with a lifestyle intervention could achieve lower increase of glucose levels by improving insulin sensitivity...
May 16, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29777843/underexpansion-of-wallstents%C3%A2-in-the-treatment-of-nonthrombotic-iliac-vein-lesions
#9
Jacob E Mandel, Yuriy Ostrozhynskyy, Anil Hingorani, Natalie Marks, Enrico Ascher
OBJECTIVE: Iliac vein stenting is increasingly being used in the treatment of venous insufficiency for patients with nonthrombotic iliac vein lesions (NIVL). We have noticed that many stents do not deploy to the expected stent area as designated by the manufactured diameter. The purpose of this study was to evaluate the dynamics of Wallstent® expansion in the iliocaval system. METHODS: Retrospective analysis of all patients with NIVL who were treated with iliac vein stenting using Wallstents®...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29777842/nationally-representative-readmission-factors-in-patients-with-claudication-and-critical-limb-ischemia
#10
Rennier A Martinez, Michelle Shnayder, Joshua Parreco, Lukas Gaffney, Marcus Eby, Nicholas Cortolillo, Michael Lopez, Jack Zeltzer
INTRODUCTION: Hospital readmissions are not only associated with increased mortality, morbidity and costs but also, with current healthcare reform, tied to significant financial and administrative penalties. Some studies show that patients undergoing vascular surgery may have higher than average readmission rates. The recently released Nationwide Readmission Database (NRD) is the most comprehensive national source of readmission data, gathering discharge information from 22 geographically dispersed states, accounting for 51...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29777827/is-reward-prediction-error-encoding-reliable-during-development
#11
Hanna Keren, Gang Chen, Brenda Benson, Monique Ernst, Ellen Leibenluft, Nathan A Fox, Daniel S Pine, Argyris Stringaris
Reward Prediction Errors (RPEs), defined as the difference between the expected and received outcomes, are integral to reinforcement learning models and play an important role in development and psychopathology. In humans, RPE encoding can be estimated using fMRI recordings, however, a basic measurement property of RPE signals, their test-retest reliability across different time scales, remains an open question. In this paper, we examine the 3-month and 3-year reliability of RPE encoding in youth (mean age at baseline = 10...
May 16, 2018: NeuroImage
https://www.readbyqxmd.com/read/29777778/anterior-approach-in-humeral-plating-osteosynthesis
#12
Daniel Handy Eone, Prudence Christelle Danielle Ngono, Marie Josée Essi, Gaël Leckpa, Kennedy Olivier Muluem, Farikou Ibrahima, Maurice Aurélien Sosso
CONTEXT: Humeral plating osteosynthesis is controversial, particularly regarding the choice between anterior and lateral approach, data for which in the context of a low-income country are lacking. HYPOTHESIS: The anterior approach is an easy surgical technique, allowing good anatomic reconstruction. We hypothesize that the anterior approach is associated with fewer neurovascular lesions and functional sequelae than the lateral approach. MATERIALS AND METHODS: A retrospective study with assessment update was carried out over a period of 6 years 4 months from January 2010 to June 2016, with consecutive recruitment in the city of Yaoundé, Cameroon...
May 16, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29777741/effect-of-exposure-to-similar-flavours-in-sensory-specific-satiety-implications-for-eating-behaviour
#13
Ana González, Sergio Andrés Recio, Jesús Sánchez, Marta Gil, Isabel de Brugada
Sensory-specific satiety (SSS) refers to a decline in pleasantness of eaten foods in comparison to other non-ingested meals. Although SSS is specific to the eaten food, it can also generalize to other meals that share similar properties to the satiated food. It is possible that this phenomenon could become more specific after extensive experience, as repeated exposure to an assortment of similar food could cause perceptual learning (i.e. an increase in the distinctiveness of each specific item). This in turn would reduce generalization from the consumed food to other similar products, so they will be more readily consumed...
May 16, 2018: Appetite
https://www.readbyqxmd.com/read/29777740/rapid-response-systems
#14
REVIEW
Patrick G Lyons, Dana P Edelson, Matthew M Churpek
INTRODUCTION: Rapid response systems are commonly employed by hospitals to identify and respond to deteriorating patients outside of the intensive care unit. Controversy exists about the benefits of rapid response systems. AIMS: We aimed to review the current state of the rapid response literature, including evolving aspects of afferent (risk detection) and efferent (intervention) arms, outcome measurement, process improvement, and implementation. DATA SOURCES: Articles written in English and published in PubMed...
May 16, 2018: Resuscitation
https://www.readbyqxmd.com/read/29777705/membrane-proteins-significantly-restrict-exosome-mobility
#15
Mikhail Skliar, Vasiliy S Chernyshev, David M Belnap, German V Sergey, Samer M Al-Hakami, Philip S Bernard, Inge J Stijleman, Rakesh Rachamadugu
Exosomes are membrane nanovesicles implicated in cell-to-cell signaling in which they transfer their molecular cargo from the parent to the recipient cells. This role essentially depends on the exosomes' small size, which is the prerequisite for their rapid migration through the crowded extracellular matrix and into and out of circulation. Here we report much lower exosome mobility than expected from the size of their vesicles, implicate membrane proteins in a substantially impeded rate of migration, and suggest an approach to quantifying the impact...
May 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29777666/analysis-of-cross-resistance-to-vip3-proteins-in-eight-insect-colonies-from-four-insect-species-selected-for-resistance-to-bacillus-thuringiensis-insecticidal-proteins
#16
Joaquín Gomis-Cebolla, Yuequin Wang, Yudong Quan, Kanglai He, Tom Walsh, Bill James, Sharon Downes, Wendy Kain, Ping Wang, Kathy Leonard, Tom Morgan, Brenda Oppert, Juan Ferré
Bacillus thuringiensis Vip3 proteins are synthesized and secreted during the vegetative growth phase. They are activated by gut proteases, recognize and bind to midgut receptors, form pores and lyse cells. We tested the susceptibility to Vip3Aa and Vip3Ca of Cry1A-, Cry2A-, Dipel- and Vip3-resistant insect colonies from different species to determine whether resistance to other insecticidal proteins confers cross-resistance to Vip3 proteins. As expected, the colonies resistant to Cry1A proteins, Dipel (Helicoverpa armigera, Trichoplusia ni, Ostrinia furnacalis and Plodia interpunctella) or Cry2Ab (H...
May 16, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29777620/vegetation-growth-enhancement-in-urban-environments-of-the-conterminous-united-states
#17
Wenxiao Jia, Shuqing Zhao, Shuguang Liu
Cities are natural laboratories for studying vegetation responses to global environmental changes because of their climate, atmospheric, and biogeochemical conditions. However, few holistic studies have been conducted on the impact of urbanization on vegetation growth. We decomposed the overall impacts of urbanization on vegetation growth into direct (replacement of original land surfaces by impervious built-up) and indirect (urban environments) components, using a conceptual framework and remotely-sensed data for 377 metropolitan statistical areas (MSAs) in the conterminous United States (CONUS) in 2001, 2006, and 2011...
May 19, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29777614/enhancing-the-detection-of-injuries-and-near-misses-among-patient-care-staff-in-a-large-pediatric-hospital
#18
Maurizio Macaluso, Lauren A Summerville, Meredith E Tabangin, Nancy M Daraiseh
Objectives Compared to other industries, healthcare has one of the highest rates of non-fatal occupational injury/illness. Evidence indicates these rates are underestimated, highlighting the need for improved injury surveillance. This study aims to demonstrate the feasibility of integrating active data collection in a passive injury surveillance system to improve detection of injuries in a healthcare establishment. Methods Using digital voice recorders (DVR), pediatric healthcare providers prospectively recorded events throughout their shift for two weeks...
May 7, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29777612/clustering-of-job-strain-effort-reward-imbalance-and-organizational-injustice-and-the-risk-of-work-disability-a-cohort-study
#19
Anne Juvani, Tuula la Oksanen, Marianna Virtanen, Paula Salo, Jaana Pentti, Mika Kivimäki, Jussi Vahtera
Objectives The aim of this study was to examine the association between co-occurring work stressors and risk of disability pension. Methods The work stressors job strain, effort-reward imbalance (ERI), and organizational injustice were measured by a survey in 2008 of 41 862 employees linked to national records of all-cause and cause-specific disability pensions until 2011. Co-occurring work stressors were examined as risk factors of work disability using Cox regression marginal models. Results Work stressors were clustered: 50...
May 2, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29777569/improving-metabolic-stability-with-deuterium-the-discovery-of-hwl-066-a-potent-and-long-acting-free-fatty-acid-receptor-1-agonists
#20
Chunxia Liu, Zheng Li, Wei Shi, Huilan Li, Nasi Wang, Yuxuan Dai, Chen Liao, Wenlong Huang, Hai Qian
The free fatty acid receptor 1 (FFA1) is a potential target due to its function in enhancing of glucose-stimulated insulin secretion. The FFA1 agonist GW9508 has great potential for the treatment of type 2 diabetes mellitus, but it has been suffering from high plasma clearance probably because the phenylpropanoic acid is vulnerable to β-oxidation. To identify orally available analog without influence on the unique pharmacological mechanism of GW9508, we tried to interdict the metabolically labile group by incorporating two deuterium atoms at the α-position of phenylpropionic acid affording compound 4 (HWL-066)...
May 18, 2018: Chemical Biology & Drug Design
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