Hye M Hwang, Satoshi Yamashita, Yu Matsumoto, Mariko Ito, Alex Edwards, Junko Sasaki, Dipankar J Dutta, Shahid Mohammad, Chiho Yamashita, Leah Wetherill, Tae-Hwi Schwantes-An, Marco Abreu, Amanda H Mahnke, Sarah N Mattson, Tatiana Foroud, Rajesh C Miranda, Christina Chambers, Masaaki Torii, Kazue Hashimoto-Torii
A hallmark of fetal alcohol spectrum disorders (FASD) is neurobehavioral deficits that still do not have effective treatment. Here, we present that reduction of Apolipoprotein E (APOE) is critically involved in neurobehavioral deficits in FASD. We show that prenatal alcohol exposure (PAE) changes chromatin accessibility of Apoe locus, and causes reduction of APOE levels in both the brain and peripheral blood in postnatal mice. Of note, postnatal administration of an APOE receptor agonist (APOE-RA) mitigates motor learning deficits and anxiety in those mice...
May 11, 2024: Molecular Psychiatry