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Estrogen receptor alpha

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https://www.readbyqxmd.com/read/28914763/emerging-estrogenic-pollutants-in-the-aquatic-environment-and-breast-cancer
#1
REVIEW
Sylvain Lecomte, Denis Habauzit, Thierry D Charlier, Farzad Pakdel
The number and amount of man-made chemicals present in the aquatic environment has increased considerably over the past 50 years. Among these contaminants, endocrine-disrupting chemicals (EDCs) represent a significant proportion. This family of compounds interferes with normal hormonal processes through multiple molecular pathways. They represent a potential risk for human and wildlife as they are suspected to be involved in the development of diseases including, but not limited to, reprotoxicity, metabolic disorders, and cancers...
September 15, 2017: Genes
https://www.readbyqxmd.com/read/28910727/gene-environment-interaction-does-fluoride-influence-the-reproductive-hormones-in-male-farmers-modified-by-er%C3%AE-gene-polymorphisms
#2
Qiang Ma, Hui Huang, Long Sun, Tong Zhou, Jingyuan Zhu, Xuemin Cheng, Lijv Duan, Zhiyuan Li, Liuxin Cui, Yue Ba
The occurrence of endemic fluorosis is derived from high fluoride levels in drinking water and industrial fumes or dust. Reproductive disruption is also a major harm caused by fluoride exposure besides dental and skeletal lesions. However, few studies focus on the mechanism of fluoride exposure on male reproductive function, especially the possible interaction of fluoride exposure and gene polymorphism on male reproductive hormones. Therefore, we conducted a cross-sectional study in rural areas of Henan province in China to explore the interaction between the estrogen receptor alpha (ERα) gene and fluoride exposure on reproductive hormone levels in male farmers living in the endemic fluorosis villages...
September 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/28903441/loss-of-steroid-hormone-receptors-is-common-in-malignant-pleural-and-peritoneal-effusions-of-breast-cancer-patients-treated-with-endocrine-therapy
#3
Willemijne A M E Schrijver, Karianne Schuurman, Annelot van Rossum, Ton Peeters, Natalie Ter Hoeve, Wilbert Zwart, Paul J van Diest, Cathy B Moelans
Discordance in estrogen receptor alpha (ERα), progesterone receptor (PR), androgen receptor (AR) and human epidermal growth factor receptor 2 (HER2) status between primary breast cancers and solid distant metastases ("conversion") has been reported previously. Even though metastatic spread to the peritoneal and pleural cavities occurs frequently and is associated with high mortality, the rate of receptor conversion and the prognostic implications thereof remain elusive. We therefore determined receptor conversion in 91 effusion metastases (78 pleural, 13 peritoneal effusions) of 69 patients by immunohistochemistry (IHC) and in situ hybridization...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28899645/transcriptome-based-discovery-of-pathways-and-genes-related-to-reproduction-of-the-black-tiger-shrimp-penaeus-monodon
#4
Tanaporn Uengwetwanit, Pattareeya Ponza, Duangjai Sangsrakru, Duangdao Wichadakul, Supawadee Ingsriswang, Rungnapa Leelatanawit, Sirawut Klinbunga, Sithichoke Tangphatsornruang, Nitsara Karoonuthaisiri
The black tiger shrimp (Penaeus monodon) is an aquatic animal with considerable economic importance. Poor reproductive maturation in captivity impedes sustainable aquaculture production of this species. This study aims to provide transcriptomic information on reproductive organs using 454 pyrosequencing technology. The transcriptome analysis of ovaries and testes revealed 41,136 transcripts with 20,192 contigs. We found novel sets of transcripts completing several important reproductive pathways such as gonadotropin-releasing hormone (GnRH) signaling and progesterone-mediated oocyte maturation...
September 9, 2017: Marine Genomics
https://www.readbyqxmd.com/read/28891935/alteration-of-mammary-gland-development-and-gene-expression-by-in-utero-exposure-to-cadmium
#5
Daniela A Parodi, Morgan Greenfield, Claire Evans, Anna Chichura, Alexandra Alpaugh, James Williams, Kedra C Cyrus, Mary Beth Martin
Environmental exposure to estrogens and estrogen like contaminants during early development is thought to contribute to the risk of developing breast cancer primarily due to an early onset of puberty; however, exposure during key developing windows may also influence the risk of developing the disease. The goal of this study was to ask whether in utero exposure to the metalloestrogen cadmium alters mammary gland development due to acceleration of puberty onset or to an effect on early development of the mammary gland...
September 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28890840/err%C3%AE-regulates-the-growth-of-triple-negative-breast-cancer-cells-via-s6k1-dependent-mechanism
#6
Adi Y Berman, Subrata Manna, Naomi S Schwartz, Yardena E Katz, Yang Sun, Catherine A Behrmann, Jane J Yu, David R Plas, Anya Alayev, Marina K Holz
Estrogen-related receptor alpha (ERRα) is an orphan nuclear factor that is a master regulator of cellular energy metabolism. ERRα is overexpressed in a variety of tumors, including ovarian, prostate, colorectal, cervical and breast, and is associated with a more aggressive tumor and a worse outcome. In breast cancer, specifically, high ERRα expression is associated with an increased rate of recurrence and a poor prognosis. Because of the common functions of ERRα and the mTORC1/S6K1 signaling pathway in regulation of cellular metabolism and breast cancer pathogenesis, we focused on investigating the biochemical relationship between ERRα and S6K1...
2017: Signal Transduction and Targeted Therapy
https://www.readbyqxmd.com/read/28890035/longitudinal-interactions-of-estrogen-receptor-alpha-gene-rs9340799-with-social-environmental-factors-on-depression-in-adolescents-after-wenchuan-earthquake
#7
Yue Feng, Jia Lin, Qiwei Guo, Mi Su, Ting Cao, Mei Fan, Xin Zhang, Yanjun Si, Nazakat H Memon, Ding Zhi Fang
Inconsistent relationships were reported between rs9340799 on estrogen receptor alpha gene (ESR1) and depression in previous studies. The present study was to explore the longitudinal changes of prevalence and severity of depression in 439 Chinese Han adolescents with different genotypes of ESR1 rs9340799 at 6, 12 and 18months after the 2008 Wenchuan earthquake. Social-environmental factors were collected by questionnaires from 465 high school students. Variants of rs9340799 were genotyped by polymerase chain reaction-restriction fragment length polymorphism analyses and verified by DNA sequencing...
September 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28889782/sex-related-hormone-receptor-in-laryngeal-squamous-cell-carcinoma-correlation-with-androgen-estrogen-%C3%A9-and-prolactin-receptor-expression-and-influence-of-prognosis
#8
Mengjia Fei, Jingwen Zhang, Jiaqing Zhou, Yanan Xu, Jiadong Wang
BACKGROUND: The expression and function of androgen receptors (AR) and estrogen receptor alpha (ER-ɑ) in laryngeal squamous cell carcinoma (LSCC) have remained controversial for decades. Prolactin receptor (PRLR) is a sex-related hormone, that has been rarely documented in terms of expression or function compared with data on other hormone receptors in laryngeal carcinoma. METHODS: This study reports on immunohistochemical and reverse transcription-polymerase chain reaction (RT-PCR) analysis of tumour tissue and adjacent normal tissue in 96 patients with LSCC (82 males and 14 females)...
September 11, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28887333/rapid-estrogen-receptor-alpha-signaling-mediated-by-erk-activation-regulates-vascular-tone-in-male-and-ovary-intact-female-mice
#9
Seong Chul Kim, Austin C Boese, Matthew H Moore, Rea M Cleland, Lin Chang, Patrice Delafontaine, Ke-Jie Yin, Jean-Pyo Lee, Milton H Hamblin
Estrogen has been shown to affect vascular reactivity. Here, we assessed estrogen receptor-alpha (ERα) dependency of estrogenic effects on vasorelaxation via a rapid nongenomic pathway in both male and ovary-intact female mice. We compared the effect of a primary estrogen, 17 beta-estradiol (E2) or 4,4',4"-(4-propyl-[1H]pyrazole-1,3,5-triyl)tris-phenol (PPT) (selective ERα agonist). We found that E2 and PPT induced greater aortic relaxation in females than males, indicating ERα mediation, which is further validated by employing ERα antagonism...
September 8, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28883902/sirt1-activation-by-resveratrol-alleviates-cardiac-dysfunction-via-mitochondrial-regulation-in-diabetic-cardiomyopathy-mice
#10
Sai Ma, Jing Feng, Ran Zhang, Jiangwei Chen, Dong Han, Xiang Li, Bo Yang, Xiujuan Li, Miaomiao Fan, Congye Li, Zuhong Tian, Yabin Wang, Feng Cao
BACKGROUND: Diabetic cardiomyopathy (DCM) is a major threat for diabetic patients. Silent information regulator 1 (SIRT1) has a regulatory effect on mitochondrial dynamics, which is associated with DCM pathological changes. Our study aims to investigate whether resveratrol, a SRIT1 activator, could exert a protective effect against DCM. METHODS AND RESULTS: Cardiac-specific SIRT1 knockout (SIRT1(KO)) mice were generated using Cre-loxP system. SIRT1(KO) mice displayed symptoms of DCM, including cardiac hypertrophy and dysfunction, insulin resistance, and abnormal glucose metabolism...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28881748/api5-a-new-cofactor-of-estrogen-receptor-alpha-involved-in-breast-cancer-outcome
#11
Céline Basset, Florence Bonnet-Magnaval, Marina Garcia-Jove Navarro, Christian Touriol, Monique Courtade, Hervé Prats, Barbara Garmy-Susini, Eric Lacazette
Api5 (Apoptosis inhibitor 5) is an anti-apoptotic factor that confers resistance to genotoxic stress in human cancer. Api5 is also expressed in endothelial cells and participates to the Estrogen Receptor α (ERα) signaling to promote cell migration. In this study, we found an over expression of Api5 in human breast cancer. Given that we show that high expression of Api5 in breast cancer patients is associated with shorter recurrence free survival, we investigated the relationship between ERα and Api5 at the molecular level...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881568/modulation-of-estrogen-related-receptor-alpha-activity-by-the-kinesin-kif17
#12
Am Pramodh Bandara Seneviratne, Zeynep Turan, Aurelie Hermant, Patrick Lecine, William O Smith, Jean-Paul Borg, Fanny Jaulin, Geri Kreitzer
Estrogen-related receptor alpha (ERR1) is an orphan nuclear receptor that can bind transcriptional co-activators constitutively. ERR1 expression correlates with poor patient outcomes in breast cancer, heightening interest in this nuclear receptor as a therapeutic target. Because ERR1 has no known regulatory ligand, a major challenge in targeting its activity is to find cellular or synthetic modulators of its function. We identified an interaction between ERR1 and KIF17, a kinesin-2 family microtubule motor, in a yeast-2-hybrid screen...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28878875/the-effects-of-17-alpha-estradiol-to-inhibit-inflammation-in-vitro
#13
Roberta S Santos, Luciana A de Fatima, Aaron P Frank, Everardo M Carneiro, Deborah J Clegg
BACKGROUND: 17 Alpha-estradiol (17 α-E2) is a natural, non-feminizing stereoisomer of 17 beta-estradiol (17 β-E2). Whereas much is known about the physiological effects of 17 β-E2, much less is known about 17 α-E2. For example, 17 β-E2 exerts anti-inflammatory effects in neurons and adipocytes through binding and activation of estrogen receptor alpha (ERα); however, if 17 α-E2 has similar effects on inflammation is currently unknown. METHODS: To begin to address this, we analyzed the ability of 17 α-E2 and 17 β-E2 to suppress lipopolysaccharide (LPS)-induced inflammation in vitro using embryonic fibroblast cells (MEF) from wild type and total body ERα (ERKO) male and female mice...
2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/28877759/the-effects-of-17-alpha-estradiol-to-inhibit-inflammation-in-vitro
#14
Roberta S Santos, Luciana A de Fatima, Aaron P Frank, Everardo M Carneiro, Deborah J Clegg
BACKGROUND: 17 Alpha-estradiol (17 α-E2) is a natural, non-feminizing stereoisomer of 17 beta-estradiol (17 β-E2). Whereas much is known about the physiological effects of 17 β-E2, much less is known about 17 α-E2. For example, 17 β-E2 exerts anti-inflammatory effects in neurons and adipocytes through binding and activation of estrogen receptor alpha (ERα); however, if 17 α-E2 has similar effects on inflammation is currently unknown. METHODS: To begin to address this, we analyzed the ability of 17 α-E2 and 17 β-E2 to suppress lipopolysaccharide (LPS)-induced inflammation in vitro using embryonic fibroblast cells (MEF) from wild type and total body ERα (ERKO) male and female mice...
September 6, 2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/28869142/gene-expression-profile-of-estrogen-receptors-alpha-and-beta-in-rat-brain-during-aging-and-following-high-fat-diet
#15
Rosaria Scudiero, Mariailaria Verderame
The "sex-hormone" estrogen-17β promotes several cognitive functions and is a master regulator of brain bioenergetics via the estrogen receptors α and β (ERα and ERβ). In this work, by using Real-Time PCR analysis, we evaluated the effect of aging and high fat diet (HFD) on ERα and ERβ expression in rat hippocampus and cortex. In young rats, ERβ is abundant in cortex and ERα in hippocampus. During the aging, in the cortex, we observe a general decrease in ERα and ERβ expression; in hippocampus ERα increases and ERβ decreases...
August 28, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/28864864/the-anticancer-estrogen-receptor-antagonist-tamoxifen-impairs-consolidation-of-inhibitory-avoidance-memory-through-estrogen-receptor-alpha
#16
Martina Lichtenfels, Arethuza da Silva Dornelles, Fernanda Dos Santos Petry, Martina Blank, Caroline Brunetto de Farias, Rafael Roesler, Gilberto Schwartsmann
Over two-thirds of women with breast cancer have positive tumors for hormone receptors, and these patients undergo treatment with endocrine therapy, tamoxifen being the most widely used agent. Despite being very effective in breast cancer treatment, tamoxifen is associated with side effects that include cognitive impairments. However, the specific aspects and mechanisms underlying these impairments remain to be characterized. Here, we have investigated the effects of tamoxifen and interaction with estrogen receptors on formation of memory for inhibitory avoidance conditioning in female rats...
September 2, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28864005/sp1-transcription-factor-is-a-modulator-of-estradiol-leptin-induction-in-placental-cells
#17
Malena Schanton, Julieta Maymó, Antonio Pérez-Pérez, Yésica Gambino, Bernardo Maskin, José Luis Dueñas, Víctor Sánchez-Margalet, Cecilia Varone
INTRODUCTION: Pleiotropic effects of leptin have been identified in reproduction and pregnancy, particularly in the placenta, where it functions as an autocrine hormone. The synthesis of leptin in normal trophoblastic cells is regulated by different endogenous biochemical agents, but the regulation of placental leptin expression is still poorly understood. We have previously reported that 17β-estradiol up-regulates placental leptin expression through genomic and nongenomic mechanisms...
September 2017: Placenta
https://www.readbyqxmd.com/read/28856246/breast-cancer-chemoprevention-pharmacogenomics-deep-sequencing-and-functional-genomics-of-the-znf423-and-ctso-genes
#18
Duan Liu, Ming-Fen Ho, Daniel J Schaid, Steven E Scherer, Krishna Kalari, Mohan Liu, Joanna Biernacka, Vivien Yee, Jared Evans, Erin Carlson, Matthew P Goetz, Michiaki Kubo, D Lawrence Wickerham, Liewei Wang, James N Ingle, Richard M Weinshilboum
Our previous GWAS using samples from the NSABP P-1 and P-2 selective estrogen receptor modulator (SERM) breast cancer prevention trials identified SNPs in ZNF423 and near CTSO that were associated with breast cancer risk during SERM chemoprevention. We have now performed Next Generation DNA sequencing to identify additional SNPs that might contribute to breast cancer risk and to extend our observation that SNPs located hundreds of bp from estrogen response elements (EREs) can alter estrogen receptor alpha (ERα) binding in a SERM-dependent fashion...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28856074/utilizing-tumor-and-plasma-liquid-biopsy-in-treatment-decision-making-for-an-estrogen-receptor-positive-advanced-breast-cancer-patient
#19
Bing Xu, Amy Krie, Pradip De, Casey Williams, Rachel Elsey, Jessica Klein, Brian Leyland-Jones
Breast cancer affects 12% of females in the United States and is the leading cause of cancer death in the female population. Personalized therapy is being used in clinical practice to treat breast cancer based on tumor molecular profiling, which can be obtained from tissue biopsy or plasma liquid biopsy as circulating tumor deoxyribonucleic acid (ctDNA). The available ctDNA tests provide a non-invasive way to monitor the cancer genome in a real-time manner. In this case report, a 38-year-old female with recurrent estrogen receptor (ER) positive breast cancer is treated with letrozole, everolimus, and palbociclib...
June 29, 2017: Curēus
https://www.readbyqxmd.com/read/28842010/a-novel-high-throughput-screening-assay-for-binding-affinities-of-perfluoroalkyl-iodide-for-estrogen-receptor-alpha-and-beta-isoforms
#20
Wenting Song, Lixia Zhao, Zhendong Sun, Xiaoxi Yang, Qunfang Zhou, Guibin Jiang
Contaminants of emerging concern are continuously increasing, which makes it important to develop high throughput screening techniques for the evaluation of their potential biological effects, especially endocrine disrupting effects, which would directly influence the population dynamics in environment. A novel competitive binding assay based on enzyme fragmentation complementation technology was established to screen the binding affinities of emerging chemicals for estrogen receptor (ER) α or β isoforms...
December 1, 2017: Talanta
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