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Candida albicans biofilm

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https://www.readbyqxmd.com/read/28213809/the-correlation-between-biofilm-production-and-catheter-related-blood-stream-infections-sustained-by-candida-a-case-control-study
#1
Grazia Brunetti, Valeria Visconti, Maria Cristina Ghezzi, Alessandra Giordano, Giammarco Raponi
Biofilm forming capacity of yeasts colonizing the intravenous devices is considered a key factor involved in the pathogenesis of Candida catheter-related bloodstream infections (CCRBSI). The biofilm production of strains of Candida spp. isolated both from the CVC and from the blood of patients with CCRBSI was compared to that of strains isolated from patients not having CCRBSI. Results, expressed in terms of Biofilm Index (BI), revealed that biofilm-producing strains were isolated in the CCRBSI group with a frequency significantly higher than in the non-CCRBSI group (χ(2) = 4...
February 18, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28211844/a-tool-named-iris-for-versatile-high-throughput-phenotyping-in-microorganisms
#2
George Kritikos, Manuel Banzhaf, Lucia Herrera-Dominguez, Alexandra Koumoutsi, Morgane Wartel, Matylda Zietek, Athanasios Typas
Advances in our ability to systematically introduce and track controlled genetic variance in microorganisms have, in the past decade, fuelled high-throughput reverse genetics approaches. When coupled to quantitative readouts, such approaches are extremely powerful at elucidating gene function and providing insights into the underlying pathways and the overall cellular network organization. Yet, until now, all efforts to quantify microbial macroscopic phenotypes have been restricted to monitoring growth in a small number of model microorganisms...
February 17, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28198976/role-of-candida-species-from-hiv-infected-children-in-enamel-caries-lesions-an-in-vitro-study
#3
Senda Charone, Maristela Barbosa Portela, Karol de Oliveira Martins, Rosangela Maria Soares, Gloria Fernanda Castro
Objectives: This study analyzed the capacity of Candida spp. from dental biofilm of HIV infected (HIV+) children to demineralize primary molar enamel in vitro by Transversal Microhardness (TMH), Polarized Light Microscopy (PLM) and the quantity of calcium ions (Ca2+) released from the enamel. Material and Methods: Candida spp. samples were isolated from the supragingival biofilm of HIV+ children. A hundred and forty (140) enamel blocks were randomly assigned to six groups: biofilm formed by C...
January 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28191638/enhancement-of-the-efficacy-of-photodynamic-inactivation-of-candida-albicans-with-the-use-of-biogenic-gold-nanoparticles
#4
Irena Maliszewska, Barbara Lisiak, Katarzyna Popko, Katarzyna Matczyszyn
This study reports on successful photodynamic inactivation of planktonic and biofilm cells of Candida albicans using Rose Bengal (RB) in combination with biogenic gold nanoparticles synthesized by the cell-free filtrate of Penicillium funiculosum BL1 strain. Monodispersed colloidal gold nanoparticles coated with proteins were characterized by a number of techniques including SEM-EDS, TEM, UV-Vis absorption and fluorescence spectroscopy, as well as Fourier transform infrared spectroscopy to be 24±3 nm spheres coated with proteins...
February 12, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28181315/emodin-a-natural-inhibitor-of-protein-kinase-ck2-suppresses-growth-hyphal-development-and-biofilm-formation-of-candida-albicans
#5
Monika Janeczko, Maciej Masłyk, Konrad Kubiński, Hieronim Golczyk
Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) is a natural secondary plant product, originally isolated from the rhizomes of Rheum palmatum. Many reports show its diuretic, vasorelaxant, anti-bacterial, anti-viral, anti-ulcerogenic, immunosuppressive, hepatoprotective, anti-inflammatory, and anti-cancer potential. Emodin is a pleiotropic molecule capable of interacting with several major molecular targets, e.g. NF-κB, AKT/mTOR, and STAT3. The compound can also act as an inhibitor of some protein kinases, with special affinity to protein kinase CK2...
February 8, 2017: Yeast
https://www.readbyqxmd.com/read/28177575/surface-coating-of-gypsum-based-molds-for-maxillofacial-prosthetic-silicone-elastomeric-material-evaluating-different-microbial-adhesion
#6
Salah Khalaf, Zaihan Ariffin, Adam Husein, Fazal Reza
PURPOSE: To compare the adhesion of three microorganisms on modified and unmodified silicone elastomer surfaces with different surface roughnesses and porosities. MATERIALS AND METHODS: Candida albicans, Streptococcus mutans, and Staphylococcus aureus were incubated with modified and unmodified silicone groups (N = 35) for 30 days at 37°C. The counts of viable microorganisms in the accumulating biofilm layer were determined and converted to cfu/cm(2) unit surface area...
February 8, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28164244/candida-krusei-and-candida-glabrata-reduce-the-filamentation-of-candida-albicans-by-downregulating-expression-of-hwp1-gene
#7
Patrícia Pimentel de Barros, Fernanda Freire, Rodnei Dennis Rossoni, Juliana Campos Junqueira, Antonio Olavo Cardoso Jorge
Pathogenicity of Candida albicans is associated with its capacity switch from yeast-like to hyphal growth. The hyphal form is capable to penetrate the epithelial surfaces and to damage the host tissues. Therefore, many investigations have focused on mechanisms that control the morphological transitions of C. albicans. Recently, certain studies have showed that non-albicans Candida species can reduce the capacity of C. albicans to form biofilms and to develop candidiasis in animal models. Then, the objective of this study was to evaluate the effects of Candida krusei and Candida glabrata on the morphogenesis of C...
February 6, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28155334/inhibitory-effects-of-the-essential-oils-%C3%AE-longipinene-and-linalool-on-biofilm-formation-and-hyphal-growth-of-candida-albicans
#8
Ranjith Kumar Manoharan, Jin-Hyung Lee, Yong-Guy Kim, Soon-Il Kim, Jintae Lee
Candida albicans is one of the most common fungal pathogens, and causes systemic and invasive infections in humans. C. albicans biofilms are composed of yeast and hyphal and pseudohyphal elements, and the transition of yeast to the hyphal stage could be a virulence factor. In this study, diverse essential oils were initially investigated for anti-biofilm activity against C. albicans strains, and cascarilla bark oil and helichrysum oil and their components α-longipinene (a major constituent of both) and linalool were found to markedly inhibit biofilm formation without affecting planktonic cell growth...
February 3, 2017: Biofouling
https://www.readbyqxmd.com/read/28152096/inhibitory-activity-of-hinokitiol-against-biofilm-formation-in-fluconazole-resistant-candida-species
#9
Dae Jin Kim, Min Woo Lee, Jeong Su Choi, Seung Gwan Lee, Jee Yoon Park, Suhng Wook Kim
The aim of this study was to investigate the ability of hinokitiol to inhibit the formation of Candida biofilms. Biofilm inhibition was evaluated by quantification of the biofilm metabolic activity with XTT assay. Hinokitiol efficiently prevented biofilm formation in both fluconazole-susceptible and fluconazole-resistant strains of Candida species. We determined the expression levels of specific genes previously implicated in biofilm development of C. albicans cells by real-time RT-PCR. The expression levels of genes associated with adhesion process, HWP1 and ALS3, were downregulated by hinokitiol...
2017: PloS One
https://www.readbyqxmd.com/read/28149170/effectiveness-of-five-antidandruff-cosmetic-formulations-against-planktonic-cells-and-biofilms-of-dermatophytes
#10
Renan Martins Dos Santos, Marcus Vinícius Dias-Souza
This study aimed to investigate the in vitro antifungal effectiveness of five different formulations against dandruff and ringworm dermatophytes. Candida albicans was also included in our assays. Fungal susceptibility tests were performed with planktonic cells and biofilms of reference strains. Microbiological and physicochemical quality parameters were assessed for all formulations. Our data indicated that the formulations were effective against the dermatophytes strains, and to our knowledge, the effectiveness of cosmetic formulations against fungal biofilms is shown for the first time...
February 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28142218/differential-effects-of-the-combination-of-tyrosol-with-chlorhexidine-gluconate-on-oral-biofilms
#11
Luana Ribeiro do Vale, Alberto Carlos Botazzo Delbem, Laís Salomão Arias, Renan Aparecido Fernandes, Ana Paula Miranda Vieira, Débora Barros Barbosa, Douglas Roberto Monteiro
OBJECTIVE: This study assessed the effect of tyrosol and chlorhexidine gluconate in combination against Candida albicans, Candida glabrata and Streptococcus mutans in the planktonic state or forming biofilms in vitro. MATERIALS AND METHODS: Checkerboard assays were performed for determination of minimum inhibitory concentration. Biofilms were cultivated during 24 h on specimens of acrylic resin and hydroxyapatite, and treated with the drugs alone or in combination twice a day for 1 min, during 3 days...
January 31, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28138698/dose%C3%A2-dependent-effect-of-lysozyme-upon-candida%C3%A2-albicans-biofilm
#12
Sarra Sebaa, Nicolas Hizette, Zahia Boucherit-Otmani, Philippe Courtois
The present study investigated the in vitro effect of lysozyme (0-1,000 µg/ml) on Candida albicans (C. albicans) biofilm development. Investigations were conducted on C. albicans ATCC 10231 and on 10 clinical isolates from dentures. Strains were cultured aerobically at 37˚C in Sabouraud broth. Yeast growth was evaluated by turbidimetry. Biofilm biomass was quantified on a polystyrene support by crystal violet staining and on acrylic surfaces by counts of colony forming units. Lysozyme affected biofilm formation to a greater extent than it affected growth...
January 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28138373/resistance-of-candida-albicans-biofilms-to-drugs-and-the-host-immune-system
#13
REVIEW
Doblin Sandai, Yasser M Tabana, Ahmad El Ouweini, Ishola Oluwaseun Ayodeji
BACKGROUND: Candida albicans is a commensal fungus that resides on mucosal surfaces and in the gastrointestinal and genitourinary tracts in humans. However, it can cause an infection when the immune system of the host is impaired or if a niche becomes available. Many C. albicans infections are due to the organism's ability to form a biofilm on implanted medical devices. A biofilm represents an optimal medium for the growth of C. albicans as it allows cells to be enclosed by a self-produced extracellular matrix (ECM)...
November 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/28138121/activity-of-allyl-isothiocyanate-and-its-synergy-with-fluconazole-against-candida-albicans-biofilms
#14
Jayant Shankar Raut, Bhagyashree Shridhar Bansode, Ashwini Khanderao Jadhav, Sankunny Mohan Karuppayil
Candidiasis involving the biofilms of Candida albicans is a threat to the immunocompromised patients. Candida biofilms are intrinsically resistant to the antifungal drugs hence novel treatment strategies are desired. The study intended to evaluate the anti-Candida activity of allyl isothiocyanate (AITC) alone and with fluconazole (FLC), particularly against the biofilms. Results exhibit the concentration-dependent activity of AITC against the planktonic growth and virulence factors of C. albicans. Significant (p <0...
January 31, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28134351/candida-albicans-stimulates-streptococcus-mutans-microcolony-development-via-cross-kingdom-biofilm-derived-metabolites
#15
Dongyeop Kim, Arjun Sengupta, Tagbo H R Niepa, Byung-Hoo Lee, Aalim Weljie, Veronica S Freitas-Blanco, Ramiro M Murata, Kathleen J Stebe, Daeyeon Lee, Hyun Koo
Candida albicans is frequently detected with heavy infection of Streptococcus mutans in plaque-biofilms from children affected with early-childhood caries, a prevalent and costly oral disease. The presence of C. albicans enhances S. mutans growth within biofilms, yet the chemical interactions associated with bacterial accumulation remain unclear. Thus, this study was conducted to investigate how microbial products from this cross-kingdom association modulate S. mutans build-up in biofilms. Our data revealed that bacterial-fungal derived conditioned medium (BF-CM) significantly increased the growth of S...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28130153/the-role-of-alg13-n-acetylglucosaminyl-transferase-in-the-expression-of-pathogenic-features-of-candida-albicans
#16
Monika Niewiadomska, Anna Janik, Urszula Perlińska-Lenart, Sebastian Piłsyk, Grażyna Palamarczyk, Joanna S Kruszewska
BACKGROUND: The pathogenic potential of Candida albicans depends on adhesion to the host cells mediated by highly glycosylated adhesins, hyphae formation and growth of biofilm. These factors require effective N-glycosylation of proteins. Here, we present consequences of up- and down-regulation of the newly identified ALG13 gene encoding N-acetylglucosaminyl transferase, a potential member of the Alg7p/Alg13p/Alg14p complex catalyzing the first two initial reactions in the N-glycosylation process...
January 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28115357/synthesis-antifungal-activity-and-biocompatibility-of-novel-dabco-compounds-and-dabco-containing-denture-base-resins
#17
Jenny L Herman, Yapin Wang, Elizabeth Lilly, Thomas Lallier, Suleiman Hamdan, Xiaoming Xu, Paul L Fidel, Mairi C Noverr
The fungal pathogen Candida albicans causes a variety of oral infections including denture stomatitis, which is characterized by inflammation of the oral mucosa in direct contact with dentures, and affects a significant number of otherwise healthy denture wearers. While antifungal treatment reduces symptoms, infections are often recurrent. One strategy to address this problem is to incorporate compounds with fungicidal activities into denture materials to prevent colonization. Our laboratory synthesized novel derivatives of DABCO (1,4-diazabicyclo[2...
January 23, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28114348/polymicrobial-ventilator-associated-pneumonia-fighting-in-vitro-candida-albicans-pseudomonas-aeruginosa-biofilms-with-antifungal-antibacterial-combination-therapy
#18
Maria E Rodrigues, Susana P Lopes, Cláudia R Pereira, Nuno F Azevedo, Anália Lourenço, Mariana Henriques, Maria O Pereira
The polymicrobial nature of ventilator-associated pneumonia (VAP) is now evident, with mixed bacterial-fungal biofilms colonizing the VAP endotracheal tube (ETT) surface. The microbial interplay within this infection may contribute for enhanced pathogenesis and exert impact towards antimicrobial therapy. Consequently, the high mortality/morbidity rates associated to VAP and the worldwide increase in antibiotic resistance has promoted the search for novel therapeutic strategies to fight VAP polymicrobial infections...
2017: PloS One
https://www.readbyqxmd.com/read/28093936/biological-activities-of-rosmarinus-officinalis-l-rosemary-extract-as-analyzed-in-microorganisms-and-cells
#19
Jonatas Rafael de Oliveira, Daiane de Jesus, Leandro Wagner Figueira, Felipe Eduardo de Oliveira, Cristina Pacheco Soares, Samira Estves Afonso Camargo, Antonio Olavo Cardoso Jorge, Luciane Dias de Oliveira
R. officinalis L. is an aromatic plant commonly used as condiment and for medicinal purposes. Biological activities of its extract were evaluated in this study, as antimicrobial effect on mono- and polymicrobial biofilms, cytotoxicity, anti-inflammatory capacity, and genotoxicity. Monomicrobial biofilms of Candida albicans, Staphylococcus aureus, Enterococcus faecalis, Streptococcus mutans and Pseudomonas aeruginosa and polymicrobial biofilms composed of C. albicans with each bacterium were formed in microplates during 48 h and exposed for 5 min to R...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28081296/short-synthetic-%C3%AE-helical-forming-peptide-amphiphiles-for-fungal-keratitis-treatment-in-vivo
#20
Hong Wu, Shaoqiong Liu, Nikken Wiradharma, Zhan Yuin Ong, Yan Li, Yi Yan Yang, Jackie Y Ying
The emergence of fungal keratitis is on the rise globally. However, current antifungal therapeutics are ineffective in severe keratomycosis. Previously reported α-helical peptides comprising 8-14 amino acids demonstrate broad-spectrum antimicrobial activity both in vitro and in vivo. Here, α-helical peptides of the optimized sequences are investigated for antifungal biofilm in vitro and in vivo using a fungal biofilm-caused mouse keratitis model. The peptides with the optimal composition demonstrate higher α-helical propensity and improve antifungal activity in dispersing Candida albicans biofilm in vitro...
January 12, 2017: Advanced Healthcare Materials
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