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Candida albicans biofilm

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https://www.readbyqxmd.com/read/28081296/short-synthetic-%C3%AE-helical-forming-peptide-amphiphiles-for-fungal-keratitis-treatment-in-vivo
#1
Hong Wu, Shaoqiong Liu, Nikken Wiradharma, Zhan Yuin Ong, Yan Li, Yi Yan Yang, Jackie Y Ying
The emergence of fungal keratitis is on the rise globally. However, current antifungal therapeutics are ineffective in severe keratomycosis. Previously reported α-helical peptides comprising 8-14 amino acids demonstrate broad-spectrum antimicrobial activity both in vitro and in vivo. Here, α-helical peptides of the optimized sequences are investigated for antifungal biofilm in vitro and in vivo using a fungal biofilm-caused mouse keratitis model. The peptides with the optimal composition demonstrate higher α-helical propensity and improve antifungal activity in dispersing Candida albicans biofilm in vitro...
January 12, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28079132/critical-role-for-cafen1-and-cafen12-of-candida-albicans-in-cell-wall-integrity-and-biofilm-formation
#2
Md Alfatah, Vinay K Bari, Anubhav S Nahar, Swati Bijlani, K Ganesan
Sphingolipids are involved in several cellular functions, including maintenance of cell wall integrity. To gain insight into the role of individual genes of sphingolipid biosynthetic pathway, we have screened Saccharomyces cerevisiae strains deleted in these genes for sensitivity to cell wall perturbing agents calcofluor white and congo red. Only deletants of FEN1 and SUR4 genes were found to be sensitive to both these agents. Candida albicans strains deleted in their orthologs, CaFEN1 and CaFEN12, respectively, also showed comparable phenotypes, and a strain deleted for both these genes was extremely sensitive to cell wall perturbing agents...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28076372/bad-to-the-bone-on-in-vitro-and-ex-vivo-microbial-biofilm-ability-to-directly-destroy-colonized-bone-surfaces-without-participation-of-host-immunity-or-osteoclastogenesis
#3
Adam Junka, Patrycja Szymczyk, Grzegorz Ziółkowski, Ewa Karuga-Kuzniewska, Danuta Smutnicka, Iwona Bil-Lula, Marzenna Bartoszewicz, Susan Mahabady, Parish Paymon Sedghizadeh
Bone infections are a significant public health burden associated with morbidity and mortality in patients. Microbial biofilm pathogens are the causative agents in chronic osteomyelitis. Research on the pathogenesis of osteomyelitis has focused on indirect bone destruction by host immune cells and cytokines secondary to microbial insult. Direct bone resorption by biofilm pathogens has not yet been seriously considered. In this study, common osteomyelitis pathogens (Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Streptococcus mutans) were grown as biofilms in multiple in vitro and ex vivo experiments to analyze quantitative and qualitative aspects of bone destruction during infection...
2017: PloS One
https://www.readbyqxmd.com/read/28072890/candida-albicans-survival-growth-and-biofilm-formation-are-differently-affected-by-mouthwashes-an-in-vitro-study
#4
Simona Paulone, Giulia Malavasi, Andrea Ardizzoni, Carlotta Francesca Orsi, Samuele Peppoloni, Rachele Giovanna Neglia, Elisabetta Blasi
Candida albicans is the most common cause of oral mycoses. The aim of the present study was to investigate in vitro the susceptibility of C. albicans to mouthwashes, in terms of growth, survival and biofilm formation. Candida albicans, laboratory strain SC5314, and 7 commercial mouthwashes were employed: 3 with 0.2% chlorhexidine digluconate; 1 with 0.06% chlorhexidine digluconate and 250 ppm F- sodium fluoride; 3 with fluorine-containing molecules. None of the mouthwashes contained ethanol in their formulations...
January 9, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28063305/inhibitory-effects-of-lactobacillus-rhamnosus-and-lactobacillus-casei-on-candida-biofilm-of-denture-surface
#5
Young-Gyun Song, Sung-Hoon Lee
OBJECTIVE: Candida albicans biofilm is associated with denture-related stomatitis and oral candidiasis of elderly. Probiotics are beneficial bacteria and have antibacterial activity against pathogenic bacteria. The purpose of this study was to investigate the antifungal activity of various probiotics against C. albicans and the inhibitory effects of probiotics on Candida biofilm on the denture surface. DESIGN: The spent culture media of various probiotics were investigated the antifungal efficacy against C...
December 31, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/28053149/employment-of-methylene-blue-irradiated-with-laser-light-source-in-photodynamic-inactivation-of-biofilm-formed-by-candida-albicans-strain-resistant-to-fluconazole
#6
Lucia Černáková, Stanislava Dižová, Helena Bujdáková
A promising approach for the eradication of biofilm formed by the yeast Candida albicans seems to be photodynamic inactivation (PDI). This work presents a use of methylene blue (MB, 1 mM) irradiated with a red laser (output power 190 mW/cm(2), wavelength 660 nm) for the eradication of a biofilm formed by the fluconazole-resistant (FLC-resistant) strain C. albicans CY 1123 compared to the standard strain C. albicans SC5314. The periods of irradiation corresponded to the fluence of 15, 23 and 57 J/cm(2) Effectiveness of PDI was evident with following percentage of survived biofilm cells: 24...
January 3, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28032543/candida-albicans-biofilm-heterogeneity-does-not-influence-denture-stomatitis-but-strongly-influences-denture-cleansing-capacity
#7
Lindsay E O'Donnell, Hasanain K A Alalwan, Ryan Kean, Gareth Calvert, Christopher J Nile, David F Lappin, Douglas Roberston, Craig Williams, Gordon Ramage, Leighann Sherry
Approximately 20% of the UK population wear some form of denture prosthesis, resulting in denture stomatitis in half of these individuals. Candida albicans is primarily attributed as the causative agent, due to its biofilm forming ability. Recently, there has been increasing evidence of C. albicans biofilm heterogeneity and the negative impact it can have clinically; however, this phenomenon has yet to be studied in relation to denture isolates. The aims of this study were to evaluate C. albicans biofilm formation of clinical denture isolates in a denture environment, and assess antimicrobial activity of common denture cleansers against these tenacious communities...
December 29, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28026958/human-%C3%AE-defensin-6-self-assembly-prevents-adhesion-and-suppresses-virulence-traits-of-candida-albicans
#8
Phoom Chairatana, I-Ling Chiang, Elizabeth M Nolan
HD6 is a host-defense peptide that contributes to intestinal innate immunity and mediates homeostasis at mucosal surfaces by forming non-covalent oligomers that capture bacteria and prevent bacterial invasion into the epithelium. Our present work illustrates a new role of HD6 in defending the host epithelium against pathogenic microorganisms. We report that HD6 blocks Candida albicans adhesion to human intestinal epithelial cells and suppresses two C. albicans virulence traits, namely invasion into human epithelial cells and biofilm formation...
December 27, 2016: Biochemistry
https://www.readbyqxmd.com/read/28011958/cationic-porphyrin-mediated-photodynamic-inactivation-of-candida-biofilms-and-the-effect-of-miconazole
#9
A Davies, S Gebremedhin, M Yee, R J Padilla, N Duzgunes, K Konopka, B Dorocka-Bobkowska
The formation of biofilms by Candida and the increasing resistance of Candida species to antifungals contribute to the high recurrence rates of denture stomatitis. This increase has stimulated an interest in antimicrobial photodynamic therapy (aPDT) as an alternative treatment. We examined the photoactivity of the porphyrin-based photosensitizer, TMP-1363, against biofilms of C. albicans, C. glabrata, C. tropicalis and C. parapsilosis, and the effect of the combined use of miconazole and aPDT. Biofilms of three American Type Culture Collection (ATCC) strains and four clinical isolates developed on poly(methyl methacrylate) (PMMA) disks, were incubated with miconazole, followed by treatment with TMP-1363 for 30 min at 37°C...
October 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28006028/synergistic-effects-and-mechanisms-of-budesonide-in-combination-with-fluconazole-against-resistant-candida-albicans
#10
Xiuyun Li, Cuixiang Yu, Xin Huang, Shujuan Sun
Candida albicans is an important opportunistic pathogen, causing both superficial mucosal infections and life-threatening systemic diseases in the clinic. The emergence of drug resistance in Candida albicans has become a noteworthy phenomenon due to the extensive use of antifungal agents and the development of biofilms. This study showed that budesonide potentiates the antifungal effect of fluconazole against fluconazole-resistant Candida albicans strains both in vitro and in vivo. In addition, our results demonstrated, for the first time, that the combination of fluconazole and budesonide can reverse the resistance of Candida albicans by inhibiting the function of drug transporters, reducing the formation of biofilms, promoting apoptosis and inhibiting the activity of extracellular phospholipases...
2016: PloS One
https://www.readbyqxmd.com/read/28003796/a-novel-targeted-untargeted-gc-orbitrap-metabolomics-methodology-applied-to-candida-albicans-and-staphylococcus-aureus-biofilms
#11
Stefan Weidt, Jennifer Haggarty, Ryan Kean, Cristian I Cojocariu, Paul J Silcock, Ranjith Rajendran, Gordon Ramage, Karl E V Burgess
INTRODUCTION: Combined infections from Candida albicans and Staphylococcus aureus are a leading cause of death in the developed world. Evidence suggests that Candida enhances the virulence of Staphylococcus-hyphae penetrate through tissue barriers, while S. aureus tightly associates with the hyphae to obtain entry to the host organism. Indeed, in a biofilm state, C. albicans enhances the antimicrobial resistance characteristics of S. aureus. The association of these microorganisms is also associated with significantly increased morbidity and mortality...
2016: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28000767/a-diketopiperazine-factor-from-rheinheimera-aquimaris-qsi02-exhibits-anti-quorum-sensing-activity
#12
Shiwei Sun, Xiaoyun Dai, Jiao Sun, Xiangguo Bu, Caihong Weng, Hui Li, Hu Zhu
An ethyl acetate (EtOAc) extract isolated from the marine bacterium, Rheinheimera aquimaris QSI02, was found to exhibit anti-quorum sensing (anti-QS) activity. A subsequent bioassay-guided isolation protocol led to the detection of an active diketopiperazine factor, cyclo(Trp-Ser). Biosensor assay data showed that the minimum inhibitory concentration (MIC) of cyclo(Trp-Ser) ranged from 3.2 mg/ml to 6.4 mg/m for several microorganisms, including Escherichia coli, Chromobacterium violaceum CV026, Pseudomonas aeruginosa PA01, Staphylococcus aureus, and Candida albicans...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27999568/potential-antifungal-targets-against-a-candida-biofilm-based-on-an-enzyme-in-the-arachidonic-acid-cascade-a-review
#13
REVIEW
Xinning Liu, Decai Wang, Cuixiang Yu, Tao Li, Jianqiao Liu, Shujuan Sun
Candida is an important opportunistic fungal pathogen, especially in biofilm associated infections. The formation of a Candida biofilm can decrease Candida sensitivity to antifungal drugs and cause drug resistance. Although many effective antifungal drugs are available, their applications are limited due to their high toxicity and cost. Seeking new antifungal agents that are effective against biofilm-associated infection is an urgent need. Many research efforts are underway, and some progress has been made in this field...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27994582/disruption-of-protein-mannosylation-affects-candida-guilliermondii-cell-wall-immune-sensing-and-virulence
#14
María J Navarro-Arias, Tatiana A Defosse, Karine Dementhon, Katalin Csonka, Erika Mellado-Mojica, Aline Dias Valério, Roberto J González-Hernández, Vincent Courdavault, Marc Clastre, Nahúm V Hernández, Luis A Pérez-García, Dhirendra K Singh, Csaba Vizler, Attila Gácser, Ricardo S Almeida, Thierry Noël, Mercedes G López, Nicolas Papon, Héctor M Mora-Montes
The fungal cell wall contains glycoproteins that interact with the host immune system. In the prominent pathogenic yeast Candida albicans, Pmr1 acts as a Golgi-resident ion pump that provides cofactors to mannosyltransferases, regulating the synthesis of mannans attached to glycoproteins. To gain insight into a putative conservation of such a crucial process within opportunistic yeasts, we were particularly interested in studying the role of the PMR1 homolog in a low-virulent species that rarely causes candidiasis, Candida guilliermondii...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27993650/glucose-modulates-antimicrobial-photodynamic-inactivation-of-candida-albicans-in-biofilms
#15
Luis Cláudio Suzuki, Ilka Tiemy Kato, Renato Araujo Prates, Caetano Padial Sabino, Tania Mateus Yoshimura, Tamires Oliveira Silva, Martha Simões Ribeiro
Candida albicans biofilm is a main cause of infections associated with medical devices such as catheters, contact lens and artificial joint prosthesis. The current treatment comprises antifungal chemotherapy that presents low success rates. Photodynamic inactivation (PDI) involves the combination of a photosensitizing compound (PS) and light to generate oxidative stress that has demonstrated effective antimicrobial activity against a broad-spectrum of pathogens, including C. albicans. This fungus senses glucose inducing an upregulation of membrane transporters that can facilitate PS uptake into the cell...
December 16, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27988224/photoinactivation-of-single-and-mixed-biofilms-of-candida-albicans-and-non-albicans-candida-species-using-phorodithazine-%C3%A2
#16
Juliana Cabrini Carmello, Fernanda Alves, Ewerton Garcia de Oliveira Mima, Janaina Habib Jorge, Vanderlei Salvador Bagnato, Ana Cláudia Pavarina
This study evaluated the effectiveness of antimicrobial photodynamic therapy (aPDT) mediated by Photodithazine(®) (PDZ) formulated in hydrogel, in the inactivation of mono and duo-species biofilms of Candida albicans, Candida glabrata and Candida tropicalis. Standardized suspensions of each strain were prepared and after biofilm formation, mono-species were treated with 150 and 175mg/L of PDZ for 20minutes (pre-irradiation time), and exposed to LED light at a dose of 37.5J/cm(2) (660nm). The duo-species biofilms (C...
December 14, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27987667/effect-of-preconditioning-cobalt-and-nickel-based-dental-alloys-with-bacillus-sp-extract-on-their-surface-physicochemical-properties-and-theoretical-prediction-of-candida-albicans-adhesion
#17
Mounyr Balouiri, Samira Bouhdid, Moulay Sadiki, Wessal Ouedrhiri, Hassan Barkai, Omar El Farricha, Saad Koraichi Ibnsouda, El Houssaine Harki
Biofilm formation on dental biomaterials is implicated in various oral health problems. Thus the challenge is to prevent the formation of this consortium of microorganisms using a safe approach such as antimicrobial and anti-adhesive natural products. Indeed, in the present study, the effects of an antifungal extract of Bacillus sp., isolated from plant rhizosphere, on the surface physicochemical properties of cobalt and nickel based dental alloys were studied using the contact angle measurements. Furthermore, in order to predict the adhesion of Candida albicans to the treated and untreated dental alloys, the total free energy of adhesion was calculated based on the extended Derjaguin-Landau-Verwey-Overbeek approach...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27982704/tramadol-an-opioid-receptor-agonist-an-inhibitor-of-growth-morphogenesis-and-biofilm-formation-in-the-human-pathogen-candida-albicans
#18
Gunderao Hanumantrao Kathwate, S Mohan Karuppayil
Tramadol is a synthetic, centrally acting low-affinity agonist of μ-opioid receptors in humans. It is used as an analgesic and is shown to have local anesthetic action. In this study, we have tried to explore its anti-Candida potential. Minimum inhibitory concentration (MIC50) and minimum fungicidal concentration (MFC) values were established. MIC50 ranged from 2 to 4 mg/mL, whereas MFC was recorded at 8 mg/mL. Also, the effect of tramadol on germ tube formation, adhesion, and biofilms in Candida albicans was studied...
December 2016: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/27976012/quorum-quenching-and-biofilm-degrading-activity-of-massoia-oil-against-candida-albicans-and-pseudomonas-aeruginosa
#19
Sut Pratiwi, T Hertiani, R Idroes, E L Lagendijk, S de Weert, Cvd Hondel
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975899/evaluation-of-lichen-compounds-as-inhibitors-of-candida-albicans-biofilms
#20
M Girardot, M Millot, C Bernard, L Mambu, C Imbert
No abstract text is available yet for this article.
December 2016: Planta Medica
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