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Candida albicans biofilm

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https://www.readbyqxmd.com/read/29235267/nitrate-esters-of-heteroaromatic-compounds-as-novel-candida-albicans-cyp51-enzyme-inhibitors
#1
Marija Smiljkovic, Minos-Timotheos Matsoukas, Eftichia Kritsi, Urska Zelenko, Simona Golic Grdodolnik, Ricardo Calhelha, Isabel Ferreira, Snezana Sankovic-Babic, Jasmina Glamoclija, Theano Fotopoulou, Maria Koufaki, Panagiotis Zoumpoulakis, Marina Sokovic
Four heteroaromatic compounds bearing nitrate esters were selected using a virtual screening procedure as putative sterol 14α-demethylase (CYP51) Candida albicans inhibitors. Compounds were examined for their inhibition on C. albicans growth and biofilm formation as well as for their toxicity. NMR studies, in silico docking and molecular dynamics simulations were used to further investigate selectivity of compounds to fungal CYP51. All compounds exhibited good antimicrobial properties, indicated with low minimal inhibitory concentrations and ability to inhibit formation of fungal biofilm...
December 13, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29234974/the-impact-of-farnesol-in-combination-with-fluconazole-on-candida-albicans-biofilm-regulation-of-erg20-erg9-and-erg11-genes
#2
Stanislava Dižová, Lucia Černáková, Helena Bujdáková
Farnesol (FAR) has already demonstrated an inhibitory effect on Candida albicans biofilm. The aim of this work was to determine the effectiveness of externally added FAR in combination with fluconazole (FLC) on Candida albicans biofilm and on regulation of the ergosterol genes ERG20, ERG9, and ERG11. The effectiveness of compounds was determined by MTT assay and evaluated by the minimal inhibitory concentrations reducing a sessile biofilm to 50% activity (0.5 μg/mL and 200 μmol/L for FLC and FAR, respectively)...
December 12, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/29234378/antibiofilm-and-anti-inflammatory-activities-of-houttuynia-cordata-decoction-for-oral-care
#3
Yasuko Sekita, Keiji Murakami, Hiromichi Yumoto, Kouji Hirao, Takashi Amoh, Natsumi Fujiwara, Katsuhiko Hirota, Hideki Fujii, Takashi Matsuo, Yoichiro Miyake, Yoshiki Kashiwada
Dental biofilms that form in the oral cavity play a critical role in the pathogenesis of several infectious oral diseases, including dental caries, periodontal disease, and oral candidiasis. Houttuynia cordata (HC, Saururaceae) is a widely used traditional medicine, for both internal and external application. A decoction of dried HC leaves (dHC) has long been consumed as a health-promoting herbal tea in Japan. We have recently reported that a water solution of HC poultice ethanol extract (wHCP) exerts antimicrobial and antibiofilm effects against several important oral pathogens...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29228383/oral-fungal-bacterial-biofilm-models-in-vitro-a-review
#4
Marlene Chevalier, Stephane Ranque, Isabelle Prêcheur
Inclusion of fungi as commensals in oral biofilm is an important innovation in oral biology, and this work aimed to review the literature on the available biofilm and related disease in vitro models. Actually, thousands of bacterial and around one hundred of fungal phylotypes can colonize the oral cavity. Taxonomic profiling combined with functional expression analysis has revealed that Candida albicans, Streptococcus mutans and prominent periodontopathogens are not always present or numerically important in candidiasis, caries, or periodontitis lesions...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29228246/clinical-impact-of-candida-spp-biofilm-production-in-a-cohort-of-patients-with-candidemia
#5
Priscilla Morais Monfredini, Ana Carolina Remondi Souza, Renan Pelluzzi Cavalheiro, Ricardo Andreotti Siqueira, Arnaldo Lopes Colombo
Persistent candidemia refers to the continued isolation of the same Candida species in the blood of a candidemic patient despite appropriate therapy. Despite the clinical importance of persistent candidemia, studies have superficially addressed the biological conditions behind this phenomenon. The aim of this study was to evaluate the correlation between the biofilm-forming ability by Candida bloodstream isolates and the persistence of infection. A total of 55 isolates of Candida were tested and characterized in two groups: (i) group I, which included seven patients with persistent candidemia, and (ii) group II, which included 18 patients with nonpersistent candidemia...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29227694/pulsed-electric-field-assisted-sensitization-of-multidrug-resistant-candida-albicans-to-antifungal-drugs
#6
Vitalij Novickij, Jurgita Švedienė, Algimantas Paškevičius, Svetlana Markovskaja, Irutė Girkontaitė, Auksė Zinkevičienė, Eglė Lastauskienė, Jurij Novickij
AIM: Determine the influence of pH on the inactivation efficiency of C. albicans in pulsed electric fields (PEF) and evaluate the possibilities for sensitization of a drug-resistant strain to antifungal drugs. MATERIALS & METHODS: The effects of PEF (2.5-25 kVcm-1) with fluconazole, terbinafine and naftifine were analyzed at a pH range of 3.0-9.0. Membrane permeabilization was determined by flow cytometry and propidium iodide. RESULTS: PEF induced higher inactivation of C...
December 11, 2017: Future Microbiology
https://www.readbyqxmd.com/read/29224997/in-vitro-assessment-of-the-anti-biofilm-activity-of-ethanol-alone-and-in-combination-with-enoxaparin-60iu
#7
María Jesús Pérez-Granda, Beatriz Alonso, Ana Rodríguez-Huerta, Carmen Rodríguez, María Guembe
INTRODUCTION: Catheter-related bloodstream infection (C-RBSI) can sometimes be managed without catheter removal by combining systemic therapy with catheter lock therapy. Most antiseptic lock solutions are made up of ethanol combined with an anticoagulant. However, data regarding the anti-biofilm activity of ethanol combined with enoxaparin are scarce. We aimed to assess the efficacy of ethanol at different concentrations combined with enoxaparin 60IU as a lock solution for eradication of the biofilm of different microorganisms...
December 7, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29223801/the-external-face-of-candida-albicans-a-proteomic-view-of-the-cell-surface-and-the-extracellular-environment
#8
Ana Gil-Bona, Ahinara Amador-García, Concha Gil, Lucia Monteoliva
The cell surface and secreted proteins are the initial points of contact between Candida albicans and the host. Improvements in protein extraction approaches and mass spectrometers have allowed researchers to obtain a comprehensive knowledge of these external subproteomes. In this paper, we review the published proteomic studies that have examined C. albicans extracellular proteins, including the cell surface proteins or surfome and the secreted proteins or secretome. The use of different approaches to isolate cell wall and cell surface proteins, such as fractionation approaches or cell shaving, have resulted in different outcomes...
December 6, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29223551/recent-advances-in-delivery-of-antifungal-agents-for-therapeutic-management-of-candidiasis
#9
REVIEW
Bhakti Sawant, Tabassum Khan
Candidiasis is a fungal infection caused by yeasts that belong to the genus Candida. There are over twenty species of Candida yeasts that can cause infection in humans, the most common of which is Candida albicans. Candida yeasts normally reside in the intestinal tract and can be found on mucous membranes and skin without causing infection; however, overgrowth of these organisms can cause symptoms to develop. Presence of other diseases that compromises the patient's immunity makes it more difficult to treat...
December 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29221859/photodynamic-antimicrobial-chemotherapy-pact-using-toluidine-blue-o-inhibits-the-viability-of-biofilm-produced-by-candida-albicans-at-different-stages-of-development
#10
Ana Paula Pinto, Isabela Bueno Rosseti, Moisés Lopes Carvalho, Bruna Graziele Marques da Silva, Carlos Alberto-Silva, Maricilia Silva Costa
BACKGROUND: Candida albicans is an opportunistic fungus producing both superficial and systemic infections, especially in immunocompromised individuals. It has been demonstrated that C. albicans ability to form biofilms is a crucial process for colonization and virulence. Furthermore, a correlation between the development of drug resistance and biofilm maturation at Candida biofilms has been shown. Photodynamic Antimicrobial Chemotherapy (PACT) is a potential antimicrobial therapy that combines visible light and a non-toxic dye, known as a photosensitizer, producing reactive oxygen species (ROS) that can kill the treated cells...
December 5, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29215338/evaluation-of-antimicrobial-durability-and-anti-biofilm-effects-in-urinary-catheters-against-enterococcus-faecalis-clinical-isolates-and-reference-strains
#11
Didem Kart, Ayşe Semra Kustimur, Meral Sağıroğlu, Ayşe Kalkancı
BACKGROUND: Enterococcus faecalis, Escherichia coli, Staphylococcus epidermidis, Pseudomonas aeruginosa and Candida albicans biofilms are major causes of catheter-associated urinary tract infections. Antimicrobial-coated or impregnated urinary catheters are seen as a possible way to prevent these infections. AIMS: To determine the biofilm-forming ability of 89 E. faecalis isolates from urinary tract infections and to compare several urinary catheters for antimicrobial durability and the inhibitory effects on biofilm formation of different laboratory strains and clinical isolates of E...
December 1, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29211119/study-of-microbial-interaction-formed-by-candida-krusei-and-candida-glabrata-in-vitro-and-in-vivo-studies
#12
Rodnei Dennis Rossoni, Patrícia Pimentel de Barros, Fernanda Freire, Jéssica Diane Dos Santos, Antonio Olavo Cardoso Jorge, Juliana Campos Junqueira
Recently, the non-albicans Candida species have become recognized as an important source of infection and oral colonization by association of different species in a large number of immunosuppressed patients. The objective of this study was to evaluate the interactions between C. krusei and C. glabrata in biofilms formed in vitro and their ability to colonize the oral cavity of mouse model. Monospecies and mixed biofilms were developed of each strain, on 96-well microtiter plates for 48 h. These biofilms were analyzed by counting colony-forming units (CFU/mL) and by determining cell viability, using the XTT hydroxide colorimetric assay...
November 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29208749/development-of-anti-virulence-approaches-for-candidiasis-via-a-novel-series-of-small-molecule-inhibitors-of-candida-albicans-filamentation
#13
Jesus A Romo, Christopher G Pierce, Ashok K Chaturvedi, Anna L Lazzell, Stanton F McHardy, Stephen P Saville, Jose L Lopez-Ribot
Candida albicans remains the main etiologic agent of candidiasis, the most common fungal infection and now the third most frequent infection in U.S. hospitals. The scarcity of antifungal agents and their limited efficacy contribute to the unacceptably high morbidity and mortality rates associated with these infections. The yeast-to-hypha transition represents the main virulence factor associated with the pathogenesis of C. albicans infections. In addition, filamentation is pivotal for robust biofilm development, which represents another major virulence factor for candidiasis and further complicates treatment...
December 5, 2017: MBio
https://www.readbyqxmd.com/read/29208208/corrigendum-to-photoinactivation-of-single-and-mixed-biofilms-of-candida-albicans-and-non-albicans-candida-species-using-photodithazine%C3%A2-photodiagn-photodyn-ther-17c-2017-194-199
#14
Juliana Cabrini Carmello, Fernanda Alves, Ewerton Garcia de Oliveira Mima, Janaina Habib Jorge, Vanderlei Salvador Bagnato, Ana Cláudia Pavarina
No abstract text is available yet for this article.
December 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29204285/molecular-characterization-of-acinetobacter-baumannii-isolated-from-iraqi-hospital-environment
#15
I M S Al-Kadmy, A N M Ali, I M A Salman, S S Khazaal
Healthcare-associated items are a common source of acquired infections, and hospital-acquired infections cause significant mortality and morbidity worldwide. Acinetobacter baumannii is the most prevalent infection-causing organism in the hospital environment. Hospital articles and objects are the main sources of infection with the ability to transmit some of the pathogenic microorganisms such as A. baumannii, which is considered a serious problem in therapeutic treatments. In the current study, we isolated A...
January 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29204075/comparative-anticancer-and-antimicrobial-activity-of-aerial-parts-of-acacia-salicina-acacia-laeta-acacia-hamulosa-and-acacia-tortilis-grown-in-saudi-arabia
#16
Mohamed F Alajmi, Perwez Alam, Saleh I Alqasoumi, Nasir Ali Siddiqui, Omer A Basudan, Afzal Hussain, Fohad Mabood Husain, Azmat Ali Khan
The standardized ethanol extract (EE) of aerial parts of four Acacia species [A. salicina (ASEE), A. laeta (ALEE), A. hamulosa (AHEE), and A. tortilis (ATEE)] were examined in order to compare their cytotoxic and antimicrobial activities. All the extracts were standardized by UPLC- PDA method using rutin as standard compound. The extracts ALEE, AHEE and ATEE were found to contain rutin along with several other phytoconstituents while rutin was absent in ASEE. All the extracts showed varying level of antimicrobial activity with zone of inhibition ranged from 11 to 21 mm against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans...
December 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29199568/lingzhi-or-reishi-medicinal-mushroom-ganoderma-lucidum-agaricomycetes-inhibits-candida-biofilms-a-metabolomic-approach
#17
Anuja Bhardwaj, Payal Gupta, Navin Kumar, Jigni Mishra, Ajai Kumar, Rajput Rakhee, Kshipra Misra
This article presents a comparative gas chromatography (GC)-mass spectrometry (MS)-based metabolomic analysis of mycelia and fruiting bodies of the medicinal mushroom Ganoderma lucidum. Three aqueous extracts-mycelia, fruiting bodies, and a mixture of them-and their sequential fractions (methanolic and ethyl acetate), prepared using an accelerated solvent extractor, were characterized by GC-MS to determine volatile organic compounds and by high-performance thin-layer chromatography to quantify ascorbic acid, a potent antioxidant...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29194441/candida-albicans-fre8-encodes-a-member-of-the-nadph-oxidase-family-that-produces-a-burst-of-ros-during-fungal-morphogenesis
#18
Diego C P Rossi, Julie E Gleason, Hiram Sanchez, Sabrina S Schatzman, Edward M Culbertson, Chad J Johnson, Christopher A McNees, Carolina Coelho, Jeniel E Nett, David R Andes, Brendan P Cormack, Valeria C Culotta
Until recently, NADPH oxidase (NOX) enzymes were thought to be a property of multicellularity, where the reactive oxygen species (ROS) produced by NOX acts in signaling processes or in attacking invading microbes through oxidative damage. We demonstrate here that the unicellular yeast and opportunistic fungal pathogen Candida albicans is capable of a ROS burst using a member of the NOX enzyme family, which we identify as Fre8. C. albicans can exist in either a unicellular yeast-like budding form or as filamentous multicellular hyphae or pseudohyphae, and the ROS burst of Fre8 begins as cells transition to the hyphal state...
December 1, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29187716/-possible-involvement-of-surface-antigen-protein-2-in-the-morphological-transition-and-biofilm-formation-of-candida-albicans
#19
Kazuko Okamoto-Shibayama, Yuichiro Kikuchi, Eitoyo Kokubu, Kazuyuki Ishihara
Surface antigen protein 2 (Csa2) is a member of the Candida albicans Common in Fungal Extracellular Membranes (CFEM) protein superfamily. We previously established its role in iron acquisition in C. albicans. However, the other roles of Csa2 remain unknown. Here, we compared growth, morphological transition, and biofilm formation among wild-type, Csa2-mutant, and complemented strains of C. albicans. Deletion of the Csa2 gene resulted in smaller and reduced colony growth, significant attenuation of the dimorphic transition under serum-inducing conditions, and reduced biofilm formation; complementation restored these levels to those of the wild-type...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/29178772/antimicrobial-action-and-long-term-effect-of-overnight-denture-cleansers
#20
Amanda Peracini, Ingrid Machado Andrade, Viviane Cássia Oliveira, Ana Paula Macedo, Claudia Helena Silva-Lovato, Valéria Oliveira Pagnano, Evandro Watanabe, Helena de Freitas Oliveira Paranhos
PURPOSE: To evaluate two denture cleansers for overnight soaking (0.5% sodium hypochlorite and peroxide alkaline) regarding efficacy against Candida spp. biofilms (randomized clinical trial) and their effects on the physical properties of a denture base acrylic resin simulating a period of 5 years of use (laboratory study). The Candida spp. were identified and their resistance to main antifungal agents was evaluated. METHODS: 32 complete denture wearers were instructed to brush their dentures three times a day and to soak them (≥8 hours) in: control - water (C); alkaline peroxide (AP); or 0...
April 2017: American Journal of Dentistry
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