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https://www.readbyqxmd.com/read/27620176/novel-fish-oil-based-bigel-system-for-controlled-drug-delivery-and-its-influence-on-immunomodulatory-activity-of-imiquimod-against-skin-cancer
#1
Khurram Rehman, Mohd Hanif Zulfakar
PURPOSE: To characterize bigel system as a topical drug delivery vehicle and to establish the immunomodulatory role of imiquimod-fish oil combination against skin cancer and inflammation resulting from chemical carcinogenesis. METHODS: Imiquimod-loaded fish oil bigel colloidal system was prepared using a blend of carbopol hydrogel and fish oil oleogel. Bigels were first characterized for their mechanical properties and compared to conventional gel systems. Ex vivo permeation studies were performed on murine skin to analyze the ability of the bigels to transport drug across skin and to predict the release mechanism via mathematical modelling...
September 12, 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/27594930/black-raspberries-in-cancer-clinical-trials-past-present-and-future
#2
Laura A Kresty, Susan R Mallery, Gary D Stoner
BACKGROUND: Black raspberries (BRB) inhibit a broad range of cancers in preclinical models, including in vivo models of oral, esophageal, colon, breast and skin cancer. Promising preclinical results have led to clinical evaluations in cancer patients or patients at increased risk for cancer development. OBJECTIVE: To summarize clinical investigations targeting cancer or precancerous lesions with BRB and discuss future directions. METHODS: A thorough literature search was conducted through December 1, 2015 to identify all published studies evaluating BRB in cancer focused clinical trials...
2016: Journal of Berry Research
https://www.readbyqxmd.com/read/27574828/role-of-dietary-ginger-zingiber-officinale-in-improving-growth-performances-and-immune-functions-of-labeo-rohita-fingerlings
#3
Venkatachalam Sukumaran, Se Chang Park, Sib Sankar Giri
This study evaluated the effects of ginger (Zingiber officinale) as a feeding supplement on the growth, skin mucus immune parameters, and cytokine-related gene expression of Labeo rohita, and its susceptibility to Aeromonas hydrophila infection. Diets containing six different concentrations of dried ginger (0% [basal diet], 0.2% [G2], 0.4% [G4], 0.6% [G6], 0.8% [G8], and 1.0% [G10] were fed to fish (average weight: 12.3 g) for 60 days. Growth parameters were examined at 30 and 60 days post-feeding. Skin mucosal immune responses and gene expression were examined 60 days post-feeding...
October 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27557877/epigallocatechin-3-gallate-augments-therapeutic-effects-of-mesenchymal-stem-cells-in-skin-wound-healing
#4
Min Li, Jingxing Xu, Tongxin Shi, Haiyang Yu, Jianping Bi, Guanzhi Chen
In non-healing wounds, mesenchymal stem cells (MSC)-based therapies have the potential to activate a series of coordinated cellular processes, including angiogenesis, inflammation, cell migration, proliferation and epidermal terminal differentiation. As pro-inflammatory reactions play indispensable roles in initiating wound repair, sustained and prolonged inflammation exhibit detrimental effects on skin wound closure. We investigated the feasibility of using an antioxidant agent epigallocatechin-3-gallate (EGCG), along with MSCs, to improve wound repair through their immunomodulatory actions...
August 25, 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27422756/methionine-hydroxy-analogue-enhanced-fish-immunity-via-modulation-of-nf-%C3%AE%C2%BAb-tor-mlck-mapks-and-nrf2-signaling-in-young-grass-carp-ctenopharyngodon-idella
#5
Fei-Yu Pan, Lin Feng, Wei-Dan Jiang, Jun Jiang, Pei Wu, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou, Yang Liu
Our study investigated the effect of dietary methionine hydroxy analogue (MHA) on growth and immunity (head kidney, spleen and skin) of young grass carp (Ctenopharyngodon idella). A total of 630 grass carp (259.70 ± 0.47 g) were fed graded levels of MHA (0, 2.4, 4.4, 6.4, 8.5 and 10.5 g/kg diet) and one dl-methionine (DLM) group (6.4 g/kg diet) for 8 weeks. At the end of the feeding trial, fish were challenged with Aeromonas hydrophila for 14 days. The results indicated that optimal MHA increased lysozyme (LZ) and acid phosphatase (ACP) activities, complement 3 (C3), C4 and immunoglobulin M (IgM) contents and up-regulated mRNA levels of liver expressed antimicrobial peptide 2, hepcidin (head kidney), β-defensin-1 in the immune organs (P < 0...
September 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27329781/struthanthus-vulgaris-ointment-prevents-an-over-expression-of-inflammatory-response-and-accelerates-the-cutaneous-wound-healing
#6
Luciane Souza Dos Santos Gramma, Franciane Martins Marques, Cátia Vittorazzi, Thiago Antônio Moretti de Andrade, Marco Andrey Cipriani Frade, Tadeu Uggere de Andrade, Denise Coutinho Endringer, Rodrigo Scherer, Marcio Fronza
ETHNOPHARMACOLOGICAL RELEVANCE: Struthanthus vulgaris (Vell.) Mart. (Loranthaceae) has been largely used in traditional folk medicine in Brazil as an anti-inflammatory agent and to treat various skin disorders, including wounds. AIMS OF THE STUDY: To investigated the influence of 5% Struthanthus vulgaris ointment during cutaneous wound healing in rats. MATERIALS AND METHODS: Twenty Wistar rats were used in each group according the daily treatment, S...
August 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27157598/dietary-low-or-excess-levels-of-lipids-reduced-growth-performance-and-impaired-immune-function-and-structure-of-head-kidney-spleen-and-skin-in-young-grass-carp-ctenopharyngodon-idella-under-the-infection-of-aeromonas-hydrophila
#7
Pei-Jun Ni, Wei-Dan Jiang, Pei Wu, Yang Liu, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou, Lin Feng
Our study explored the effect of dietary lipids on growth and immunity and structure (head kidney, spleen and skin) of young grass carp (Ctenopharyngodon idella). A total of 540 young grass carp with an average initial weight of 261.41 ± 0.53 g were fed diets containing six graded levels of lipids at 5.9-80.1 g/kg diet for 8 weeks. After that, a challenge trial was conducted by injection of Aeromonas hydrophila over 2 weeks. The results indicated that compared with optimal lipids supplementation, low and excess levels of lipids down-regulated the mRNA levels of antimicrobial peptides, anti-inflammatory cytokines, inhibitor of κBα (IκBα) and ribosomal p70S6 kinase (S6K1), and up-regulated pro-inflammatory cytokines, nuclear factor κB p65 (NF-κB p65), NF-κB c-Rel (not p52), IκB kinase α (IKKα), IKKβ, IKKγ, and eIF4E-binding protein (4EBP) mRNA levels in the head kidney and spleen of young grass carp (P < 0...
August 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27149136/paraneoplastic-scleroderma-are-there-any-clues
#8
Hana Jedlickova, Veronika Durčanská, Vladimír Vašků
Dear Editor, Scleroderma associated with neoplasia is rare, with only a small number of cases reported. We describe 4 patients with paraneoplastic scleroderma who were treated at the I. Department of Dermatovenereology, St. Anna Hospital, during the period between 2004 and 2014. The patients were diagnosed with cholangiogenic carcinoma, endometrial carcinoma, prostatic adenocarcinoma, and adenoma of the suprarenal gland. In the case of concurrent scleroderma and tumor, four situations may occur: they can develop independently of each other; scleroderma may be induced by the tumor; the tumor can develop in the scleroderma; or the tumor can be induced by immunosuppressive therapy...
April 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27098624/fibroblast-growth-factor-23-and-placental-growth-factor-in-patients-with-psoriasis-and-their-relation-to-disease-severity
#9
Gökhan Okan, Adile Merve Baki, Eda Yorulmaz, Semra Doğru-Abbasoğlu, Pervin Vural
PURPOSE: Psoriasis is an immune-mediated skin disease characterised by accentuated keratinocyte proliferation, hyperkeratinisation, leukocyte and T-lymphocyte chemotaxis, and neoangiogenesis. Chronic inflammation, imbalance between pro- and anti-inflammatory cytokines, and many angiogenic mediators has been implicated in the disease etiopathogenesis. The aim of this study was to investigate whether psoriasis is related to fibroblast growth factor 23 (FGF23) and placental growth factor (PLGF) - mediators related to insulin resistance (IR), metabolic syndrome, and atherosclerosis...
2016: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/26944716/dietary-vitamin-c-deficiency-depresses-the-growth-head-kidney-and-spleen-immunity-and-structural-integrity-by-regulating-nf-%C3%AE%C2%BAb-tor-nrf2-apoptosis-and-mlck-signaling-in-young-grass-carp-ctenopharyngodon-idella
#10
Hui-Jun Xu, Wei-Dan Jiang, Lin Feng, Yang Liu, Pei Wu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou
This study investigated the effects of dietary vitamin C on the growth, and head kidney, spleen and skin immunity, structural integrity and related signaling molecules mRNA expression levels of young grass carp (Ctenopharyngodon idella). A total of 540 grass carp (264.37 ± 0.66 g) were fed six diets with graded levels of vitamin C (2.9, 44.2, 89.1, 133.8, 179.4 and 224.5 mg/kg diet) for 10 weeks. Subsequently, a challenge test was conducted by injection of Aeromonas hydrophila and the survival rate recorded for 14 days...
May 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/26876681/immunomodulatory-effectiveness-of-fish-oil-and-omega-3-fatty-acids-in-human-non-melanoma-skin-carcinoma-cells
#11
Khurram Rehman, Mohd Cairul Iqbal Mohd Amin, Ng Pei Yuen, Mohd Hanif Zulfakar
Fish oil is composed of various fatty acids among which omega-3 fatty acids are considered as most beneficial. The effects of fish oil on the activity of a topical anticancer drug, imiquimod, and the immunomodulatory activity of omega-3 fatty acids was investigated in human basal and squamous cell carcinoma cell lines. Imiquimod-fish oil mixture exhibited higher carcinoma cell growth inhibition and immunomodulatory activity than imiquimod alone, especially against squamous cell carcinoma cells. Omega-3 fatty acids exhibited growth inhibition of both basal cell and squamous cell carcinoma cell lines and modulated the immune response...
2016: Journal of Oleo Science
https://www.readbyqxmd.com/read/26806620/phosphodiesterase-4-in-inflammatory-diseases-effects-of-apremilast-in-psoriatic-blood-and-in-dermal-myofibroblasts-through-the-pde4-cd271-complex
#12
Peter H Schafer, Francesca Truzzi, Anastasia Parton, Lei Wu, Jolanta Kosek, Ling-Hua Zhang, Gerald Horan, Annalisa Saltari, Marika Quadri, Roberta Lotti, Alessandra Marconi, Carlo Pincelli
Phosphodiesterases 4 (PDE4) act as proinflammatory enzymes via degradation of cAMP, whereas PDE4 inhibitors play an anti-inflammatory role in vitro and in vivo. In particular, apremilast has been recently approved for the treatment of psoriasis and psoriatic arthritis. However, little is known on the expression pattern of PDE4 in psoriasis. We report that PDE4B and PDE4D mRNA are overexpressed in peripheral blood mononuclear cells (PBMC) from psoriasis, as compared with normal controls, while apremilast reduces PBMC production of a number of pro-inflammatory cytokines and increases the levels of anti-inflammatory mediators...
July 2016: Cellular Signalling
https://www.readbyqxmd.com/read/26481525/in-vitro-studies-of-antifibrotic-and-cytoprotective-effects-elicited-by-proto-berberine-alkaloids-in-human-dermal-fibroblasts
#13
Daniele Pietra, Alice Borghini, Anna Maria Bianucci
BACKGROUND: The pathogenic mechanisms of skin fibrosis are still not completely understood, unlike the profibrotic role played by inflammatory cytokines and transforming growth factor-β1 (TGF-β1). Few antifibrotic drugs are available. Nevertheless, folk medicine suggests numerous treatments of fibrotic conditions. Based on information from folk medicine and literature, the hypothesis was made that proto-berberine alkaloids could act as antifibrotic and cytoprotective agents. METHODS: The effects of berberine, dihydroberberine, canadine, stylopine, and coptisine were investigated on an in vitro model of fibrosis purposely set up...
December 2015: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/26271575/immunological-and-histopathological-characterization-of-cutaneous-candidiasis
#14
Tacito Graminha Campois, Amanda Zaparoli Zucoloto, Eduardo José de Almeida Araujo, Terezinha Inez Estivalet Svidizinski, Ricardo Sergio Almeida, Gustavo Fernando da Silva Quirino, Raquel Mitie Harano, Ivete Conchon-Costa, Ionice Felipe
Chronic mucocutaneous candidiasis constitutes a heterogeneous group of syndromes, characterized by non-invasive infection of the skin, nails and mucosal membranes by the fungus Candida spp. Although symptoms are heterogeneous, in all cases there is a reduction in protective cytokines, favouring the development of disease. The normal role of cytokines in skin lesions is not well understood. The present study aimed to investigate the progression of disease, understand specific cellular and molecular components involved in immunity to Candida albicans and determine the balance between pro- and anti-inflammatory cytokines over the course of cutaneous infection in immunocompetent mice...
August 2015: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/26253490/advances-in-the-pharmacological-activities-and-mechanisms-of-diosgenin
#15
REVIEW
Yan Chen, You-Mei Tang, Su-Lan Yu, Yu-Wei Han, Jun-Ping Kou, Bao-Lin Liu, Bo-Yang Yu
Diosgenin, a well-known steroid sapogenin derived from plants, has been used as a starting material for production of steroidal hormones. The present review will summarize published literature concerning pharmacological potential of diosgenin, and the underlying mechanisms of actions. Diosgenin has shown a vast range of pharmacological activities in preclinical studies. It exhibits anticancer, cardiovascular protective, anti-diabetes, neuroprotective, immunomodulatory, estrogenic, and skin protective effects, mainly by inducing apoptosis, suppressing malignant transformation, decreasing oxidative stress, preventing inflammatory events, promoting cellular differentiation/proliferation, and regulating T-cell immune response, etc...
August 2015: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/26192381/opportunistic-pathogen-candida-albicans-elicits-a-temporal-response-in-primary-human-mast-cells
#16
José Pedro Lopes, Marios Stylianou, Gunnar Nilsson, Constantin F Urban
Immunosuppressed patients are frequently afflicted with severe mycoses caused by opportunistic fungal pathogens. Besides being a commensal, colonizing predominantly skin and mucosal surfaces, Candida albicans is the most common human fungal pathogen. Mast cells are present in tissues prone to fungal colonization being expectedly among the first immune cells to get into contact with C. albicans. However, mast cell-fungus interaction remains a neglected area of study. Here we show that human mast cells mounted specific responses towards C...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26187706/mitochondria-targeted-antioxidant-skq1-improves-impaired-dermal-wound-healing-in-old-mice
#17
Ilya A Demyanenko, Ekaterina N Popova, Vlada V Zakharova, Olga P Ilyinskaya, Tamara V Vasilieva, Valeria P Romashchenko, Artem V Fedorov, Vasily N Manskikh, Maxim V Skulachev, Roman A Zinovkin, Olga Yu Pletjushkina, Vladimir P Skulachev, Boris V Chernyak
The process of skin wound healing is delayed or impaired in aging animals. To investigate the possible role of mitochondrial reactive oxygen species (mtROS) in cutaneous wound healing of aged mice, we have applied the mitochondria-targeted antioxidant SkQ1. The SkQ1 treatment resulted in accelerated resolution of the inflammatory phase, formation of granulation tissue, vascularization and epithelization of the wounds. The wounds of SkQ1-treated mice contained increased amount of myofibroblasts which produce extracellular matrix proteins and growth factors mediating granulation tissue formation...
July 2015: Aging
https://www.readbyqxmd.com/read/26167817/-investigation-of-the-effect-of-ibuprofen-on-wound-healing-in-experimental-staphylococcus-aureus-soft-tissue-infections
#18
M Uğur Çitil, Ergun Mete, E Oğuzhan Oğuz, Gülçin Abban Mete, Barbaros Şahin, İlknur Kaleli
Soft tissue infections (STIs) occur as a result of the colonization of pathogenic bacteria upon the destruction of normal skin microbial flora and the skin integrity. Streptococci and staphylococci are the most frequent causes of bacterial STIs. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen are often used in STIs because of their analgesic and antipyretic effects. However, evidence suggests that these drugs might delay both epithelization and angiogenesis in the early phases of wound healing because of an antiproliferative effect...
April 2015: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/26154512/naringenin-inhibits-uvb-irradiation-induced-inflammation-and-oxidative-stress-in-the-skin-of-hairless-mice
#19
Renata M Martinez, Felipe A Pinho-Ribeiro, Vinicius S Steffen, Carla V Caviglione, Josiane A Vignoli, Décio S Barbosa, Marcela M Baracat, Sandra R Georgetti, Waldiceu A Verri, Rubia Casagrande
Ultraviolet B (UVB) irradiation may cause inflammation- and oxidative-stress-dependent skin cancer and premature aging. Naringenin (1) has been reported to have anti-inflammatory and antioxidant properties, but its effects and mechanisms on UVB irradiation-induced inflammation and oxidative stress are still not known. Thus, the present study aimed to investigate the potential of naringenin to mitigate UVB irradiation-induced inflammation and oxidative damage in the skin of hairless mice. Skin edema, myeloperoxidase (neutrophil marker) and matrix metalloproteinase-9 (MMP-9) activity, and cytokine production were measured after UVB irradiation...
July 24, 2015: Journal of Natural Products
https://www.readbyqxmd.com/read/26152211/effect-of-ampelopsis-radix-on-wound-healing-in-scalded-rats
#20
Kyungjin Lee, Byonghee Lee, Mi-Hwa Lee, Bumjung Kim, Khanita Suman Chinannai, Inhye Ham, Ho-Young Choi
BACKGROUND: Ampelopsis Radix has been used as a traditional Korean medicine for the treatment of burns and scalds. However, there has been no scientific research to date on the wound healing properties of Ampelopsis Radix for scald burns. This study aimed to evaluate the healing effect of Ampelopsis japonica root tuber ethanol extract (AJE) on induced cutaneous scald injury in Sprague Dawley (SD) rats. METHODS: Hot water scalds were induced in SD rats, who were then divided into the following 5 groups; 1) control group without treatment, 2) positive control group with 1% Silver sulfadiazine (SSD), 3) Vaseline group, and groups 4) and 5) that used Vaseline containing 5% and 20% AJE, respectively...
2015: BMC Complementary and Alternative Medicine
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