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Constantinos Markopoulos, Maria Vertzoni, Apostolos Agalias, Prokopios Magiatis, Christos Reppas
OBJECTIVES: We aimed to assess the intralumenal stability of oleuropein in human gastric and small intestinal contents. We additionally aimed to assess the stability characteristics of oleuropein in media simulating the intralumenal conditions. METHODS: The intralumenal stability of oleuropein was assessed in aspirates from the stomach and the upper small intestine of healthy volunteers collected under both fasted and fed state conditions and in media simulating the intralumenal environment...
February 2009: Journal of Pharmacy and Pharmacology
Caroline Puel, Julie Mardon, Apostolis Agalias, Marie-Jeanne Davicco, Patrice Lebecque, Andre Mazur, Marie-Noelle Horcajada, Alexios-Leandros Skaltsounis, Veronique Coxam
This study was conducted to determine whether the daily consumption for 84 days of tyrosol and hydroxytyrosol, the main olive oil phenolic compounds, and olive oil mill wastewater (OMWW), a byproduct of olive oil production, rich in micronutrients, may improve bone loss in ovariectomized rats (an experimental model of postmenopausal osteoporosis) and in ovariectomized rats with granulomatosis inflammation (a model set up for senile osteoporosis). As expected, an induced chronic inflammation provoked further bone loss at total, metaphyseal, and diaphyseal sites in ovariectomized rats...
October 22, 2008: Journal of Agricultural and Food Chemistry
Caroline Puel, Julie Mardon, Séraphin Kati-Coulibaly, Marie-Jeanne Davicco, Patrice Lebecque, Christiane Obled, Edmond Rock, Marie-Noelle Horcajada, Apostolos Agalias, Leandros A Skaltsounis, Véronique Coxam
This study was conducted to determine whether olive fruits, rich in micronutrients, might improve bone loss in ovariectomized (OVX) rats (an experimental model of postmenopausal osteoporosis) and in OVX rats with granulomatosis inflammation (a model of senile osteoporosis). Six-month-old Wistar female rats underwent ovariectomy and were then immediately treated orally by substituting oil in the diet by 10 g/d green Lucques olives or 6 g/d black Lucques olives for each rat for 84 days. OVX rats and sham-operated controls received the same diet with oil...
May 2007: British Journal of Nutrition
Apostolis Agalias, Prokopios Magiatis, Alexios-Leandros Skaltsounis, Emmanuel Mikros, Anthony Tsarbopoulos, Evagelos Gikas, Ioannis Spanos, Thrasyvoulos Manios
The high polyphenol content of the wastewater is the major environmental problem caused by the olive mills. A pilot scale system for the treatment of the olive oil mills wastewater was developed aiming at the recovery of high added value-contained polyphenols and the reduction of the environmental problems. The treatment system consists of three main successive sections: The first one includes successive filtration stages aiming at the gradual reduction of the wastewater suspended solids up to a limit of 25 microm...
April 4, 2007: Journal of Agricultural and Food Chemistry
Ioanna Andreadou, Efstathios K Iliodromitis, Emmanuel Mikros, Maria Constantinou, Apostolos Agalias, Prokopios Magiatis, Alexios Leandros Skaltsounis, Elli Kamber, Anna Tsantili-Kakoulidou, Dimitrios Th Kremastinos
Thgoal of this study was to evaluate the efficacy of the antioxidant olive constituent, oleuropein, on infarct size, oxidative damage, and the metabolic profile in rabbits subjected to ischemia. Oleuropein, 10 or 20 mg/(kg x d), was administered to 8 groups that consumed a normal or hypercholesterolemic diet for 6 wk or only the higher dose for 3 wk. Circulating levels of malondialdehyde, protein carbonyl, nitrite+nitrate, cholesterol, triglycerides, SOD activity, and the metabolic profile were measured using 1H NMR spectra...
August 2006: Journal of Nutrition
Caroline Puel, Jacinthe Mathey, Apostolis Agalias, Séraphin Kati-Coulibaly, Julie Mardon, Christiane Obled, Marie-Jeanne Davicco, Patrice Lebecque, Marie-Noelle Horcajada, Alexios L Skaltsounis, Véronique Coxam
BACKGROUND & AIMS: This study was carried out to assess the dose-dependent bone-sparing effect of oleuropein, an olive oil phenolic compound with anti-inflammatory and anti-oxidative properties, on bone loss induced by talc granulomatosis in oestrogen-deficient rat. METHODS: Among 98 rats, 20 were sham-operated (SH) while the others (78) were ovariectomised (OVX). The SH and 26 OVX rats (controls) were given a standard diet for 100 days. The 52 remaining OVX rats were allocated to 4 groups that received oleuropein at 2...
October 2006: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Lambros Nousis, Paschalis-Thomas Doulias, Nektarios Aligiannis, Dimitrios Bazios, Apostolos Agalias, Dimitrios Galaris, Sofia Mitakou
In search for compounds, able to protect nuclear DNA in cells exposed to oxidative stress, extracts from olive leaves, olive fruits, olive oil and olive mill waste water were tested by using the "single cell gel electrophoresis" methodology (comet assay). Jurkat cells in culture were exposed to continuously generated hydrogen peroxide (11.8+/-1.5 microM per min) by direct addition into the growth medium of the appropriate amount of the enzyme "glucose oxidase" in the presence or absence of the tested total extracts...
July 2005: Free Radical Research
C Puel, A Quintin, A Agalias, J Mathey, C Obled, A Mazur, M J Davicco, P Lebecque, A L Skaltsounis, V Coxam
The present study was designed to evaluate the effect of olive oil and its main polyphenol (oleuropein) in ovariectomised rats with or without inflammation. Rats (6 months old) were ovariectomised or sham-operated as control. Ovariectomised rats were separated into three groups receiving different diets for 3 months: a control diet with 25 g peanut oil and 25 g rapeseed oil/kg (OVX), the control diet with 50 g olive oil/kg or the control diet with 0.15 g oleuropein/kg. The sham-operated group was given the same control diet as OVX...
July 2004: British Journal of Nutrition
A Agalias, N Mihopoulos, M Tsoukatou, L Marinos, C Vagias, C Harvala, V Roussis
Three new prostaglandins were isolated as minor constituents of the organic extract from the Caribbean soft coral Plexaura nina. The structures of the new natural products were established by means of spectral data analysis, including 2D NMR experiments. The unpalatability of the lipid extract of the coral and the defensive role of the major prostaglandin metabolites were determined by laboratory and field fish-feeding assays.
May 2000: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
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