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https://www.readbyqxmd.com/read/28944123/preventing-cushing-iatrogenic-cushing-syndrome-due-to-ritonavir-fluticasone-interaction
#1
Fasil Tiruneh, Ahmad Awan, Abiot Didana, Saumil Doshi
Ritonavir is commonly used in low doses to boost plasma levels of protease inhibitors in patients with human immunodeficiency virus (HIV) infections. It is also a potent inhibitor of cytochrome P450. We present a 50-year-old African American male with past medical history of HIV on highly active antiretroviral therapy (HAART), which also included ritonavir and long standing asthma that has been treated with inhaled fluticasone, who presented with back pain. He had central obesity, prominent abdominal striae and wasted extremities on physical examination...
July 17, 2017: Curēus
https://www.readbyqxmd.com/read/28941198/porcine-circovirus-like-virus-p1-in-cattle-goats-and-rabbits-in-china
#2
L Wen, A Mao, Z Fan, W Li, Q Xiao, Q Liu, J Xie, K He
Porcine circovirus-like virus P1, a novel single-stranded circular DNA virus, is a potential causative agent of post-weaning multisystemic wasting syndrome in swine. In this study, we detected P1 strains in serum samples from cattle, goats and rabbits suffering different clinical symptoms, in Jiangsu Province, China. We sequenced the whole genomes of six P1 strains, which showed 99.4%-100% nucleotide sequence similarity and were closely related to other porcine-origin P1 isolates. The sequences of six non-porcine-origin P1 viruses were most closely phylogenetically related to other porcine-origin P1 sequences...
September 21, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28932769/microrna-expression-in-a-phosphaturic-mesenchymal-tumour
#3
Darrell Green, Irina Mohorianu, Isabelle Piec, Jeremy Turner, Clare Beadsmoore, Andoni Toms, Richard Ball, John Nolan, Iain McNamara, Tamas Dalmay, William D Fraser
Phosphaturic mesenchymal tumours are a heterogeneous set of bone and soft tissue neoplasms that can cause a number of paraneoplastic syndromes such as tumour induced osteomalacia. The term phosphaturic comes from the common finding that these tumours secrete high levels of fibroblast growth factor 23 which causes renal phosphate wasting leading to hypophosphatemia. Phosphaturic mesenchymal tumours are rare and diagnosis is difficult. A very active 68 year old male presented with bone pain and muscle weakness...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/28932182/concurrence-of-inappropriate-antidiuretic-hormone-secretion-and-cerebral-salt-wasting-syndromes-after-traumatic-brain-injury
#4
Bo Shen, Lin Li, Ting Li
Syndrome of inappropriate antidiuretic hormone (SIADH) and cerebral salt wasting syndrome (CSWS) as the two most common neuroendocrine diseases, have been recognized and understood by many neurologists. Although SIADH and CSWS are the common causes of central hyponatremia after traumatic brain injury (TBI), a few cases are mixed, with the coexistence of the two pathological pathomechanism. However, the mixed type of both SIADH and CSWS has not been clearly reported in any literature. Here, we present the first description of the concurrent syndrome of SIADH and CSWS after TBI in four patients who underwent standard diagnostic procedures, treatment and follow up...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28931575/case-report-of-clitoral-hypertrophy-in-2-extremely-premature-girls-with-an-ovarian-cyst
#5
Anne-Laure Nerré, Pierre Bétrémieux, Sylvie Nivot-Adamiak
Neonatal clitoromegaly is mainly attributed to in utero androgen exposure secondary to congenital adrenal hyperplasia. We report on 2 extremely premature girls with clitoromegaly, increased androgen levels, no salt wasting syndrome, and ovarian cyst. In case 1, the cyst liquid was aspired during ovarian hernia surgery and revealed high androgen levels. After aspiration, serum androgen levels decreased, as did clitoral size. In case 2, an ovarian cyst was seen on pelvic ultrasound. Aspiration was not indicated...
September 20, 2017: Pediatrics
https://www.readbyqxmd.com/read/28928419/the-histone-deacetylase-sirt6-blocks-myostatin-expression-and-development-of-muscle-atrophy
#6
Sadhana A Samant, Abhinav Kanwal, Vinodkumar B Pillai, Riyue Bao, Mahesh P Gupta
Muscle wasting, also known as cachexia, is associated with many chronic diseases, which worsens prognosis of primary illness leading to enhanced mortality. Molecular basis of this metabolic syndrome is not yet completely understood. SIRT6 is a chromatin-bound member of the sirtuin family, implicated in regulating many cellular processes, ranging from metabolism, DNA repair to aging. SIRT6 knockout (SIRT6-KO) mice display loss of muscle, fat and bone density, typical characteristics of cachexia. Here we report that SIRT6 depletion in cardiac as well as skeletal muscle cells promotes myostatin (Mstn) expression...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28924035/stat1-modulates-tissue-wasting-or-overgrowth-downstream-from-pdgfr%C3%AE
#7
Chaoyong He, Shayna C Medley, Jang Kim, Chengyi Sun, Hae Ryong Kwon, Hiromi Sakashita, Yair Pincu, Longbiao Yao, Danielle Eppard, Bojie Dai, William L Berry, Timothy M Griffin, Lorin E Olson
Platelet-derived growth factor (PDGF) acts through two conserved receptor tyrosine kinases: PDGFRα and PDGFRβ. Gain-of-function mutations in human PDGFRB have been linked recently to genetic diseases characterized by connective tissue wasting (Penttinen syndrome) or overgrowth (Kosaki overgrowth syndrome), but it is unclear whether PDGFRB mutations alone are responsible. Mice with constitutive PDGFRβ signaling caused by a kinase domain mutation (D849V) develop lethal autoinflammation. Here we used a genetic approach to investigate the mechanism of autoinflammation in Pdgfrb(+/D849V) mice and test the hypothesis that signal transducer and activator of transcription 1 (STAT1) mediates this phenotype...
September 18, 2017: Genes & Development
https://www.readbyqxmd.com/read/28922413/exploitation-of-stable-nanostructures-based-on-the-mouse-polyomavirus-for-development-of-a-recombinant-vaccine-against-porcine-circovirus-2
#8
Martin Fraiberk, Michaela Hájková, Magdaléna Krulová, Martina Kojzarová, Alena Drda Morávková, Ivan Pšikal, Jitka Forstová
The aim of this study was to develop a suitable vaccine antigen against porcine circovirus 2 (PCV2), the causative agent of post-weaning multi-systemic wasting syndrome, which causes significant economic losses in swine breeding. Chimeric antigens containing PCV2b Cap protein sequences based on the mouse polyomavirus (MPyV) nanostructures were developed. First, universal vectors for baculovirus-directed production of chimeric MPyV VLPs or pentamers of the major capsid protein, VP1, were designed for their exploitation as vaccines against other pathogens...
2017: PloS One
https://www.readbyqxmd.com/read/28914668/minimally-invasive-palmaris-longus-abductorplasty-for-severe-carpal-tunnel-syndrome
#9
Sze-Ryn Chung, Robert Tze-Jin Yap, Andrew Yam Kean Tuck
Camitz abductorplasty is the most commonly used tendon transfer in patients with severe carpal tunnel syndrome with significant muscle wasting and loss of opposition. This procedure requires a long incision in the palm to harvest a strip of palmar aponeurosis to lengthen the palmaris longus tendon, allowing it to reach the abductor pollicis brevis insertion. Several complications have been attributed to this extensive dissection in the palm. We describe a minimally invasive palmaris longus abductorplasty using a strip of free flexor carpi radialis tendon graft to achieve the necessary length...
September 13, 2017: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/28913489/cerebral-salt-wasting-syndrome-in-patients-with-minor-head-trauma-two-case-reports
#10
Gabriela Csipak, Natalia Hagau
We describe two polytrauma patients without severe head trauma who developed Cerebral Salt Wasting Syndrome (CSWS) during their stay in our ICU with natriuresis, hyponatremia and hypovolemia. Hyponatremia encountered in CSWS and the syndrome of inadequate antidiuretic hormone secretion (SIADH) is a common electrolyte finding in patients with severe head trauma, subarachnoid hemorrhage, malignancy and infections of the central nervous system. CSWS was an unexpected electrolyte finding in our patients with minor head trauma without neurological or neurosurgical problems...
October 2016: Rom J Anaesth Intensive Care
https://www.readbyqxmd.com/read/28910802/effects-of-expanded-hemodialysis-therapy-on-clinical-outcomes
#11
Sandip Mitra, Kunaal Kharbanda
The invention of dialysis has been a phenomenal advance in the treatment of kidney failure. The introduction of artificial kidneys in clinical care remains one of the most successful lifesaving interventions in modern medicine. Its glory, however, has been tempered by poor long-term outcomes and a negative qualitative impact on the lives of patients who suffer from an extremely complex, burdensome, and restricted life on dialysis. There remains a huge gap in patient well-being and outcomes between artificial kidney treatments and kidney transplantation...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28910791/inflammation-and-protein-energy-wasting-in-the-uremic-milieu
#12
Magdalena Jankowska, Gabriela Cobo, Bengt Lindholm, Peter Stenvinkel
Inflammation is normally a protective and physiological response to harmful stimuli, but typically becomes an uncontrolled, maladaptive, and persistent process in patients with end-stage renal disease (ESRD). Through a deleterious cascade of poorly controlled reactions mediated by biologically active molecules (also called middle molecular weight uremia retention solutes), inflammation associates with a range of complications including cardiovascular disease and protein-energy wasting (PEW). Persistent inflammation, which is central to the conceptual etiological models of PEW and the malnutrition, inflammation, and atherosclerosis syndrome, induces and reignites processes leading to PEW in a number of ways including stimulation of both direct and indirect mechanisms of muscle proteolysis...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28889266/occupational-metal-exposure-and-parkinsonism
#13
W Michael Caudle
Parkinsonism is comprised of a host of neurological disorders with an underlying clinical feature of movement disorder, which includes many shared features of bradykinesia, tremor, and rigidity. These clinical outcomes occur subsequent to pathological deficits focused on degeneration or dysfunction of the nigrostriatal dopamine system and accompanying pathological inclusions of alpha-synuclein and tau. The heterogeneity of parkinsonism is equally matched with the complex etiology of this syndrome. While a small percentage can be attributed to genetic alterations, the majority arise from an environmental exposure, generally composed of pesticides, industrial compounds, as well as metals...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28870138/a-plea-for-the-newborn-diagnosis-of-hb-s-hereditary-persistence-of-fetal-hemoglobin
#14
Graham R Serjeant, Beryl E Serjeant, Ian R Hambleton, Matthew Oakley, Swee Lay Thein, Barnaby Clark
The gene for hereditary persistence of fetal hemoglobin (HPFH) in the Caribbean is much more common than previously estimated. To avoid labeling persons with the benign syndrome Hb S (HBB: c.20A>T)/HPFH as a disease and wasting scarce resources, parental studies are recommended when newborn screening reveals a pattern consistent with an SS phenotype.
September 5, 2017: Hemoglobin
https://www.readbyqxmd.com/read/28863142/assessing-the-accuracy-of-blood-rna-profiles-to-identify-patients-with-post-concussion-syndrome-a-pilot-study-in-a-military-patient-population
#15
Jimmaline J Hardy, Scott R Mooney, Andrea N Pearson, Dawn McGuire, Daniel J Correa, Roger P Simon, Robert Meller
Mild traumatic brain injury (mTBI) is a complex, neurophysiological condition that can have detrimental outcomes. Yet, to date, no objective method of diagnosis exists. Physical damage to the blood-brain-barrier and normal waste clearance via the lymphatic system may enable the detection of biomarkers of mTBI in peripheral circulation. Here we evaluate the accuracy of whole transcriptome analysis of blood to predict the clinical diagnosis of post-concussion syndrome (PCS) in a military cohort. Sixty patients with clinically diagnosed chronic concussion and controls (no history of concussion) were recruited (retrospective study design)...
2017: PloS One
https://www.readbyqxmd.com/read/28845764/mini-review-on-cachexia-related-mirna
#16
REVIEW
Fábio Sousa Nunes, Daniel Moreira-Gonçalves, Tiago Henriques-Coelho
Cachexia, or muscle wasting, is a complex metabolic syndrome associated with an underlying illness and characterized by loss of muscle mass. It is a rather prevalent condition, with impacts on patient survival, response to treatment, and quality of life. Treatment options are sparse because of cachexia's multifactorial pathogenesis. Recently, attention has focused on microRNAs (miRNAs) as potential therapeutic targets of several diseases. miRNAs are small, 18- to 25-base-long constructs that regulate gene expression on a post-transcriptional level, selectively activating or repressing elements of specific signaling pathways...
2017: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/28840900/-dimensions-of-work-ethic-as-predictors-of-strategies-to-cope-with-stress
#17
Damian Grabowski, Anita Pollak, Agnieszka Czerw
BACKGROUND: The article presents the mutual relations between the components of work ethic and the strategies of coping with stress used by employees of different branches. MATERIAL AND METHODS: Work ethic was presented as a syndrome of the following attitudes: perceiving work as a moral value, treating work as a central value in life, and the belief in the importance of hard work that leads to success. This ethic also consists of the following components: unwillingness to waste time, disapproval of spare time (anti-leisure), willingness to delay gratification, willingness to act honestly at work (morality/ethic), and being independent (self-reliance)...
August 25, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28840197/associations-of-protein-energy-wasting-syndrome-criteria-with-body-composition-and-mortality-in-the-general-and-moderate-chronic-kidney-disease-populations-in-the-united-states
#18
Srinivasan Beddhu, Xiaorui Chen, Guo Wei, Dominic Raj, Kalani L Raphael, Robert Boucher, Michel B Chonchol, Maureen A Murtaugh, Tom Greene
INTRODUCTION: It is unknown whether the criteria used to define Protein-energy wasting (PEW) syndrome in dialysis patients reflect protein or energy wasting in the general and moderate CKD populations. METHODS: In 11,834 participants in the 1999-2004 National Health and Nutrition Examination Survey, individual PEW syndrome criteria and the number of PEW syndrome categories were related to lean body and fat masses (measured by dual-energy absorptiometry) using linear regression in the entire cohort and CKD sub-population...
May 2017: KI Reports
https://www.readbyqxmd.com/read/28837713/the-hereditary-paraganglioma-pheochromocytoma-syndrome-no-time-to-waste
#19
Michael J Hall, Andrea D Forman, Elias Obeid
No abstract text is available yet for this article.
August 24, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28837712/the-hereditary-paraganglioma-pheochromocytoma-syndrome-no-time-to-waste-reply
#20
Naruhiko Ikoma, Dejka Araujo, Christina L Roland
No abstract text is available yet for this article.
August 24, 2017: JAMA Oncology
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