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https://www.readbyqxmd.com/read/29248930/sesamin-protects-against-cardiac-remodeling-via-sirt3-ros-pathway
#1
Di Fan, Zheng Yang, Fang-Yuan Liu, Ya-Ge Jin, Ning Zhang, Jian Ni, Yuan Yuan, Hai-Han Liao, Qing-Qing Wu, Man Xu, Wei Deng, Qi-Zhu Tang
BACKGROUND/AIMS: Cardiac remodeling is associated with oxidative stress. Sesamin, a well-known antioxidant from sesamin seeds, have been used extensively as traditional health foods. However, there is little known about the effect of sesamin on cardiac remodeling. Therefore, the present study aimed to determine whether sesamin could protect against cardiac remodeling and to clarify potential molecular mechanisms. METHODS: The mice were subjected to either transverse aortic constriction (TAC) or sham surgery (control group)...
December 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29238467/neuroprotection-of-a-sesamin-derivative-1-2-bis-3-methoxyphenyl-methyl-ethane-1-2-dicaroxylic-acid-mmeda-against-ischemic-and-hypoxic-neuronal-injury
#2
Chang-Tsen Hung, Li-Dian Chen, Chien-Wei Hou
Objectives: Stroke may cause severe neuronal damage. The sesamin have been demonstrated to possess neuroprotection by its antioxidant and anti-inflammatory properties. One sesamin derivative was artificially composited, 1, 2-bis [(3-methoxyphenyl) methyl] ethane-1, 2-dicaroxylic acid (MMEDA) had been developed to study its antioxidative activity and neuroprotection. Materials and Methods: The infaction of Sprague Dawley (SD) rats and hypoxia models of BV-2 microglia or PC12 cells were investigated for in vivo and in vitro test respectively...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29237438/effects-of-sesamin-on-primary-human-synovial-fibroblasts-and-sw982-cell-line-induced-by-tumor-necrosis-factor-alpha-as-a-synovitis-like-model
#3
Manatsanan Khansai, Thanyaluck Phitak, Jeerawan Klangjorhor, Sasimol Udomrak, Kanda Fanhchaksai, Peraphan Pothacharoen, Prachya Kongtawelert
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic synovitis, cartilage degradation and bone deformities. Synovitis is the term for inflammation of the synovial membrane, an early stage of RA. The pathogenesis of the disease occurs through cytokine induction. The major cytokine that increases the severity of RA is TNF-α. Thus, inhibition of the TNF-α cascade is an effective way to diminish the progression of the disease. We are interested in investigating the difference between primary human synovial fibroblast (hSF) cells and SW982 as synovitis models induced by TNF-α and in monitoring their responses to sesamin as an anti-inflammatory phytochemical...
December 13, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29232753/solvent-extraction-and-gc-ms-analysis-of-sesame-seeds-for-determination-of-bioactive-antioxidant-fatty-acid-fatty-oil-components
#4
Abdul Qadir, Athar Ali, Muhammad Arif, Abdulmohsen H Al-Rohaimi, Satya Prakash Singh, Usama Ahmad, Mohd Khalid, Arun Kumar
The seed kernels of Sesamum indicum L. (family: Pedaliaceae) were extracted with ethanol and yield of components determined by Gas Chromatography/Mass Spectrometry (GC/MS). The free radical scavenging activities of ethanolic extract against1, 1-Diphenyl-2-picrylhydrazyl (DPPH) were determined by UV spectrophotometer at 517 nm. Phytochemical screening revealed the presence of numerous bioactive compounds including steroids, phenolic, terpenoids, fatty acids and different types of ester compounds. The ethanolic extract was purified and analyzed by GC MS...
December 12, 2017: Drug Research
https://www.readbyqxmd.com/read/29207906/synthetic-studies-on-optically-active-furofuran-and-diarylbutane-lignans
#5
Naoki Mori
Lignans are a large class of naturally occurring secondary metabolites which are widely spread within the plant kingdom. Their diverse structures and variety of biological activities have fascinated organic chemists. For synthesizing optically active lignans, we have developed the novel asymmetric dimerization of cinnamic acid derivatives, and applied it to the enantioselective syntheses of furofuran lignans (yangambin, sesamin, eudesmin, caruilignan A) and diarylbutane lignans (sauriols A and B). This review summarizes the methodology of our asymmetric dimerization of cinnamic acid derivatives, and efficient total syntheses of furofuran and diarylbutane lignans reported by our and other groups...
December 6, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29201084/design-and-synthesis-of-some-novel-fluorobenzimidazoles-substituted-with-structural-motifs-present-in-physiologically-active-natural-products-for-antitubercular-activity
#6
Bangalore Nandha, Laxmivenkatesh Gurachar Nargund, Shachindra Laxmivenkatesh Nargund, Kishore Bhat
Keeping in view the drawbacks associated with research on anti-TB drugs based on plant extracts and the non-availability of fluorinated natural products with antitubercular activity has prompted us to make an effort towards the synthesis and characterization of a novel series of fifteen substituted fluorobenzimidazoles. The newly synthesized compounds were characterized by I.R, 1H-NMR, 13C-NMR, Mass, and elemental analysis. The synthesized compounds 4(a-f) and 5(b-j) have been evaluated for their in-vitro antimycobacterial activity against H37Rv strain (ATCC 27294) by MABA method...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29032105/a-comprehensive-review-on-the-anti-cancer-properties-and-mechanisms-of-action-of-sesamin-a-lignan-in-sesame-seeds-sesamum-indicum
#7
REVIEW
Amin F Majdalawieh, Mariam Massri, Gheyath K Nasrallah
Sesamin is the major active ingredient is Sesamum indicum seeds. Several studies revealed that sesamin possesses potent anti-cancer properties. The anti-cancer effects of sesamin have been mainly attributed to its anti-proliferative, pro-apoptotic, anti-inflammatory, anti-metastatic, anti- and pro-angiogenic, and pro-autophagocytic activities. In this review, we provide a comprehensive summary of the reported anti-cancer effects of sesamin, both in vitro and in vivo. Experimental findings related to the potential of sesamin to attenuate oxidative stress, inflammation, proliferation, metastasis, and angiogenesis in various cancer cells and tumors are analyzed...
October 12, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28933089/-chemical-constituents-from-the-fruits-of-vitex-negundo-var-cannabifolia-and-their-biological-activities-in-vitro
#8
Yue-Ting Li, Dao-Ran Pang, Zhi-Xiang Zhu, Hui-Xia Huo, Yi Ren, Zhi-Tian Peng, Jiao Zheng, Yun-Fang Zhao, Peng-Fei Tu, Jun Li
Chemical constituents from the fruits of Vitex negundo var. cannabifolia and their nitric oxide (NO) inhibitory and cytotoxic activities were investigated. The compounds were isolated and purified by various column chromatography, and their structures were identified by physiochemical properties and spectroscopic data. Thirteen lignans and six phenolic compounds were isolated from the CH2Cl2 extract of the fruits of V. negundo var. cannabifolia, respectively. Their structures were elucidated as 6-hydroxy-4-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7-methoxy-3,4-dihydro-2-naphthaldehyde (1), vitedoin A (2), vitexdoin F (3), detetrahydroconidendrin (4), vitexdoin E (5), 4-oxosesamin (6), L-sesamin (7), (+)-beechenol (8), ligballinol (9), 2-(4-hydroxyphenyl)-6-(3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo[3...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28880114/a-new-pair-of-enantiomeric-lignans-from-the-fruits-of-morinda-citrifolia-and-their-absolute-configuration
#9
Wen-Jian Liu, Yue-Juan Chen, Dan-Na Chen, Ya-Ping Wu, Yu-Jie Gao, Jing Li, Wen-Jun Zhong, Lin Jiang
A new pair of sesamin-type lignan enantiomers (±)-morifolia A (1a/1b) together with eight known analogues (2-9) were isolated from the fruits of Morinda citrifolia. Their structures were established by spectroscopic data and the absolute configurations of 1a/1b were determined by ECD calculation. All compounds were examined for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW 264.7 macrophages, and compounds 1a, 1b, 2-4 and 7-9 exhibited pronounced inhibition with IC50 values in the range of 1...
September 7, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28861734/inhibitory-effects-of-sesamin-on-human-osteoclastogenesis
#10
Orawan Wanachewin, Peraphan Pothacharoen, Prachya Kongtawelert, Thanyaluck Phitak
The promotional nature of sesamin on human osteoblast differentiation has been proven. Here, the effect of sesamin on human osteoclasts was investigated in terms of differentiation and function in M-CSF and RANKL induced human PBMCs. Sesamin treatment significantly decreased the number of differentiated osteoclasts observed by TRAP staining; however, sesamin inhibition did not result from the alteration of precursor cell proliferation. Sesamin did not decrease NFATc1 gene expression, which opposed the decreasing trend of CathK and TRAP expression...
August 31, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28844238/mechanisms-of-chromosomal-aberrations-induced-by-sesamin-metabolites-in-chinese-hamster-lung-cells
#11
Yoshiko Ono, Namino Tomimori, Hisako Hori, Yoshinori Kitagawa, Hiroshi Shibata
Sesamin is a major lignan in sesame seeds and oil. We previously demonstrated that sesamin induces chromosomal aberrations (CA) in Chinese hamster lung (CHL/IU) cells in the presence of a metabolic activation system (S9 mix), although no genotoxicity was detected in vivo. To clarify the mechanism of CA induction by sesamin, we identified its principal active metabolite. A mono-catechol derivative, [2-(3,4-methylenedioxyphenyl)-6-(3,4-dihydroxyphenyl)-3,7-dioxabi-cyclo[3.3.0]octane (SC-1)], was previously identified in culture medium when sesamin was incubated with S9 mix...
October 2017: Mutation Research
https://www.readbyqxmd.com/read/28770828/sesamin-alleviates-blood-brain-barrier-disruption-in-mice-with-experimental-traumatic-brain-injury
#12
Ying-Liang Liu, Zhi-Ming Xu, Guo-Yuan Yang, Dian-Xu Yang, Jun Ding, Hao Chen, Fang Yuan, Heng-Li Tian
Sesamin, a major lignan of sesame oil, was reported to have neuroprotective effects in several brain injury models. However, its protective action in maintaining blood-brain barrier (BBB) integrity has not been studied. In this study we investigated the effects of sesamin on the BBB in a mouse model of traumatic brain injury (TBI) and explored the underlying mechanisms. Adult male C57BL/6 mice were subjected to a controlled cortical impact (CCI) injury and then received sesamin (30 mg·kg(-1)·d(-1), ip). The mice were euthanized on the 1(st) and 3(rd) days after CCI injury and samples were collected for analysis...
November 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28726929/sesamin-prevents-apoptosis-and-inflammation-after-experimental-myocardial-infarction-by-jnk-and-nf-%C3%AE%C2%BAb-pathways
#13
Di Fan, Zheng Yang, Yuan Yuan, Qing-Qing Wu, Man Xu, Ya-Ge Jin, Qi-Zhu Tang
Myocardial infarction is a devastating event, especially when reperfusion is not performed. The inflammatory response has been associated with the pathogenesis of left ventricular remodeling after myocardial infarction. This study focused on the anti-apoptotic and anti-inflammatory effects of sesamin on ligation of the left anterior descending artery in an experimental mouse model and the potential mechanism underlying the activation of JNK and NF-κB pathways. Mice with MI induced by surgical left anterior descending coronary artery ligation were treated with sesamin by gavage for 1 week...
August 1, 2017: Food & Function
https://www.readbyqxmd.com/read/28618355/chemical-constituents-from-the-fruits-of-ligustrum-japonicum-and-their-inhibitory-effects-on-t-cell-activation
#14
Quynh-Mai Thi Ngo, Hyun-Su Lee, Van Thu Nguyen, Jeong Ah Kim, Mi Hee Woo, Byung Sun Min
A previously undescribed nor-dammarane, 3β,20,23-trihydroxy-24,25,26,27-tetranordammarane; three previously undescribed secoiridoid glycosides, ligujaponosides A-B, and iso-oleonuzhenide; and twenty three known compounds, were isolated from the fruits of Ligustrum japonicum Thunb. Their chemical structures were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR, and HRMS. The isolated compounds were screened for immunosuppressive effects on T activated cells by evaluating interleukin-2 (IL-2) production...
September 2017: Phytochemistry
https://www.readbyqxmd.com/read/28569157/effects-of-sesamin-on-chondroitin-sulfate-proteoglycan-synthesis-induced-by-interleukin-1beta-in-human-chondrocytes
#15
Warunee Srisuthtayanont, Dumnoensun Pruksakorn, Prachya Kongtawelert, Peraphan Pothacharoen
BACKGROUND: Numerous studies have reported on the health benefits of sesamin, a major lignin found in sesame (S. indicum) seeds. Recently, sesamin was shown to have the ability to promote chondroitin sulfate proteoglycan synthesis in normal human chondrocytes. This study assesses the anti-inflammatory effect of sesamin on proteoglycans production in 3D chondrocyte cultures. METHODS: To evaluate the effects of sesamin on IL-1β-treated human articular chondrocytes (HAC) pellets, the pellets were pre-treated with IL-1β then cultured in the presence of various concentrations of sesamin for 21 days...
May 31, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28567424/effect-of-naringenin-quercetin-and-sesamin-on-xenobiotica-metabolizing-cyp1a-and-cyp3a-in-mice-offspring-after-maternal-exposure-to-persistent-organic-pollutants
#16
Nadezhda Pilipenko, Erik Ropstad, Ruth Halsne, Galia Zamaratskaia
The aim of the present study was to evaluate in vitro effects of dietary phytochemicals naringenin, quercetin, and sesamin on the activities of ethoxy- (EROD; CYP1A) and benzyloxy- (BROD; CYP3A) resorufin O-dealkylases after the exposure to the cocktail of persistent organic pollutants (POPs). CD-1 mice were exposed from weaning, through gestation and lactation to a defined mixture of POPs. Hepatic microsomes were prepared from their female offspring at postnatal day 42. Hepatic EROD and BROD activity were evaluated in the presence of quercetin, naringenin, and sesamin at nine concentrations from 5 to 100000 nM...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28499502/sesamin-encouraging-effects-on-chondrogenic-differentiation-of-human-amniotic-fluid-derived-mesenchymal-stem-cells
#17
Suteera Narakornsak, Sirinda Aungsuchawan, Peeraphan Pothacharoen, Runchana Markmee, Waleephan Tancharoen, Tanongsak Laowanitwattana, Chawapon Thaojamnong, Lamaiporn Peerapapong, Nonglak Boonma, Witoon Tasuya, Junjira Keawdee, Naree Poovachiranon
Worldwide, the most recognized musculoskeletal degenerative disease is osteoarthritis (OA). Sesamin, a major abundant lignan compound present in Sesamun Indicum Linn, has been described for its various pharmacological effects and health benefits. However, the promoting effects of sesamin on chondrogenic differentiation have not yet been observed. Herein, the aim of this study was to investigate the effects of sesamin on cell cytotoxicity and the potent supporting effects on chondrogenic differentiation of human amniotic fluid-derived mesenchymal stem cells (hAF-MSCs)...
May 9, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28472971/larvicidal-activity-of-lignans-and-alkaloid-identified-in-zanthoxylum-piperitum-bark-toward-insecticide-susceptible-and-wild-culex-pipiens-pallens-and-aedes-aegypti
#18
Soon-Il Kim, Young-Joon Ahn
BACKGROUND: The yellow fever mosquito, Aedes aegypti, and the common house mosquito, Culex pipiens pallens, transmit dengue fever and West Nile virus diseases, respectively. This study was conducted to determine the toxicity of the three lignans (-)-asarinin, sesamin and (+)-xanthoxylol-γ,γ-dimethylallylether (XDA), and the alkaloid pellitorine from Zanthoxylum piperitum (Rutaceae) bark to third-instar larvae from insecticide-susceptible C. pipiens pallens and Ae. aegypti as well as wild C...
May 4, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28358428/novel-therapeutic-effects-of-sesamin-on-diabetes-induced-cardiac-dysfunction
#19
Tran Duong Thuy, Nam Nhut Phan, Chih-Yang Wang, Han-Gang Yu, Shu-Yin Wang, Pung-Ling Huang, Yi-Yin Do, Yen-Chang Lin
Diabetes is a risk factor that increases the occurrence and severity of cardiovascular events. Cardiovascular complications are the leading cause of mortality of 75% of patients with diabetes >40 years old. Sesamin, the bioactive compound extracted from Sesamum indicum, is a natural compound that has diverse beneficial effects on hypoglycemia and reducing cholesterol. The aim of this study is to investigate sesamin effects to diabetes-inducing cardiac hypertrophy. In the present study bioinformatics analysis demonstrated cardiac hypertrophy signaling may be the most important pathway for upregulating genes in sesamin-treated groups...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28239780/sesamin-extends-lifespan-through-pathways-related-to-dietary-restriction-in-caenorhabditis-elegans
#20
Yumiko Nakatani, Yukie Yaguchi, Tomomi Komura, Masakazu Nakadai, Kenji Terao, Eriko Kage-Nakadai, Yoshikazu Nishikawa
PURPOSE: Sesamin, a polyphenolic compound found in sesame seeds, has been reported to exert a variety of beneficial health effects. We have previously reported that sesamin increases the lifespan of Caenorhabditis elegans. In this study, we investigated the molecular mechanisms underlying the longevity effect of sesamin in C. elegans. METHODS: Starting from three days of age, Caenorhabditis elegans animals were fed a standard diet alone or supplemented with sesamin...
February 26, 2017: European Journal of Nutrition
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