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Sesamin

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https://www.readbyqxmd.com/read/28618355/chemical-constituents-from-the-fruits-of-ligustrum-japonicum-and-their-inhibitory-effects-on-t-cell-activation
#1
Quynh-Mai Thi Ngo, Hyun-Su Lee, Van Thu Nguyen, Jeong Ah Kim, Mi Hee Woo, Byung Sun Min
A previously undescribed nor-dammarane, 3β,20,23-trihydroxy-24,25,26,27-tetranordammarane; three previously undescribed secoiridoid glycosides, ligujaponosides A-B, and iso-oleonuzhenide; and twenty three known compounds, were isolated from the fruits of Ligustrum japonicum Thunb. Their chemical structures were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR, and HRMS. The isolated compounds were screened for immunosuppressive effects on T activated cells by evaluating interleukin-2 (IL-2) production...
June 12, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28569157/effects-of-sesamin-on-chondroitin-sulfate-proteoglycan-synthesis-induced-by-interleukin-1beta-in-human-chondrocytes
#2
Warunee Srisuthtayanont, Dumnoensun Pruksakorn, Prachya Kongtawelert, Peraphan Pothacharoen
BACKGROUND: Numerous studies have reported on the health benefits of sesamin, a major lignin found in sesame (S. indicum) seeds. Recently, sesamin was shown to have the ability to promote chondroitin sulfate proteoglycan synthesis in normal human chondrocytes. This study assesses the anti-inflammatory effect of sesamin on proteoglycans production in 3D chondrocyte cultures. METHODS: To evaluate the effects of sesamin on IL-1β-treated human articular chondrocytes (HAC) pellets, the pellets were pre-treated with IL-1β then cultured in the presence of various concentrations of sesamin for 21 days...
May 31, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28567424/effect-of-naringenin-quercetin-and-sesamin-on-xenobiotica-metabolizing-cyp1a-and-cyp3a-in-mice-offspring-after-maternal-exposure-to-persistent-organic-pollutants
#3
Nadezhda Pilipenko, Erik Ropstad, Ruth Halsne, Galia Zamaratskaia
The aim of the present study was to evaluate in vitro effects of dietary phytochemicals naringenin, quercetin, and sesamin on the activities of ethoxy- (EROD; CYP1A) and benzyloxy- (BROD; CYP3A) resorufin O-dealkylases after the exposure to the cocktail of persistent organic pollutants (POPs). CD-1 mice were exposed from weaning, through gestation and lactation to a defined mixture of POPs. Hepatic microsomes were prepared from their female offspring at postnatal day 42. Hepatic EROD and BROD activity were evaluated in the presence of quercetin, naringenin, and sesamin at nine concentrations from 5 to 100000 nM...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28499502/sesamin-encouraging-effects-on-chondrogenic-differentiation-of-human-amniotic-fluid-derived-mesenchymal-stem-cells
#4
Suteera Narakornsak, Sirinda Aungsuchawan, Peeraphan Pothacharoen, Runchana Markmee, Waleephan Tancharoen, Tanongsak Laowanitwattana, Chawapon Thaojamnong, Lamaiporn Peerapapong, Nonglak Boonma, Witoon Tasuya, Junjira Keawdee, Naree Poovachiranon
Worldwide, the most recognized musculoskeletal degenerative disease is osteoarthritis (OA). Sesamin, a major abundant lignan compound present in Sesamun Indicum Linn, has been described for its various pharmacological effects and health benefits. However, the promoting effects of sesamin on chondrogenic differentiation have not yet been observed. Herein, the aim of this study was to investigate the effects of sesamin on cell cytotoxicity and the potent supporting effects on chondrogenic differentiation of human amniotic fluid-derived mesenchymal stem cells (hAF-MSCs)...
May 9, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28472971/larvicidal-activity-of-lignans-and-alkaloid-identified-in-zanthoxylum-piperitum-bark-toward-insecticide-susceptible-and-wild-culex-pipiens-pallens-and-aedes-aegypti
#5
Soon-Il Kim, Young-Joon Ahn
BACKGROUND: The yellow fever mosquito, Aedes aegypti, and the common house mosquito, Culex pipiens pallens, transmit dengue fever and West Nile virus diseases, respectively. This study was conducted to determine the toxicity of the three lignans (-)-asarinin, sesamin and (+)-xanthoxylol-γ,γ-dimethylallylether (XDA), and the alkaloid pellitorine from Zanthoxylum piperitum (Rutaceae) bark to third-instar larvae from insecticide-susceptible C. pipiens pallens and Ae. aegypti as well as wild C...
May 4, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28358428/novel-therapeutic-effects-of-sesamin-on-diabetes-induced-cardiac-dysfunction
#6
Tran Duong Thuy, Nam Nhut Phan, Chih-Yang Wang, Han-Gang Yu, Shu-Yin Wang, Pung-Ling Huang, Yi-Yin Do, Yen-Chang Lin
Diabetes is a risk factor that increases the occurrence and severity of cardiovascular events. Cardiovascular complications are the leading cause of mortality of 75% of patients with diabetes >40 years old. Sesamin, the bioactive compound extracted from Sesamum indicum, is a natural compound that has diverse beneficial effects on hypoglycemia and reducing cholesterol. The aim of this study is to investigate sesamin effects to diabetes-inducing cardiac hypertrophy. In the present study bioinformatics analysis demonstrated cardiac hypertrophy signaling may be the most important pathway for upregulating genes in sesamin-treated groups...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28239780/sesamin-extends-lifespan-through-pathways-related-to-dietary-restriction-in-caenorhabditis-elegans
#7
Yumiko Nakatani, Yukie Yaguchi, Tomomi Komura, Masakazu Nakadai, Kenji Terao, Eriko Kage-Nakadai, Yoshikazu Nishikawa
PURPOSE: Sesamin, a polyphenolic compound found in sesame seeds, has been reported to exert a variety of beneficial health effects. We have previously reported that sesamin increases the lifespan of Caenorhabditis elegans. In this study, we investigated the molecular mechanisms underlying the longevity effect of sesamin in C. elegans. METHODS: Starting from three days of age, Caenorhabditis elegans animals were fed a standard diet alone or supplemented with sesamin...
February 26, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28157651/sesamin-imparts-neuroprotection-against-intrastriatal-6-hydroxydopamine-toxicity-by-inhibition-of-astroglial-activation-apoptosis-and-oxidative-stress
#8
Tourandokht Baluchnejadmojarad, Monireh Mansouri, Jamileh Ghalami, Zahra Mokhtari, Mehrdad Roghani
Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders in elders. Sesamin is a lignan compound and the active constituent of sesame oil with antioxidant and anti-inflammatory properties. This study was carried out to explore the mechanisms underlying sesamin effect against unilateral striatal 6-hydroxydopamine (6-OHDA) model of PD. Intrastriatal 6-OHDA-lesioned rats were pretreated with sesamin at doses of 10 or 20mg/kg/day for one week. Sesamin at a dose of 20mg/kg attenuated motor imbalance in narrow beam test, lowered striatal level of malondialdehyde (MDA) and reactive oxygen species (ROS), improved superoxide dismutase (SOD) activity, lowered striatal caspase 3 activity and α-synuclein expression, attenuated glial fibrillary acidic protein (GFAP) immunoreactivity, depressed nigral neuronal apoptosis, and prevented damage of dopaminergic neurons using tyrosine hydroxylase (TH) immunohistochemistry...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28152041/differential-and-directional-estrogenic-signaling-pathways-induced-by-enterolignans-and-their-precursors
#9
Yun Zhu, Kayoko Kawaguchi, Ryoiti Kiyama
Mammalian lignans or enterolignans are metabolites of plant lignans, an important category of phytochemicals. Although they are known to be associated with estrogenic activity, cell signaling pathways leading to specific cell functions, and especially the differences among lignans, have not been explored. We examined the estrogenic activity of enterolignans and their precursor plant lignans and cell signaling pathways for some cell functions, cell cycle and chemokine secretion. We used DNA microarray-based gene expression profiling in human breast cancer MCF-7 cells to examine the similarities, as well as the differences, among enterolignans, enterolactone and enterodiol, and their precursors, matairesinol, pinoresinol and sesamin...
2017: PloS One
https://www.readbyqxmd.com/read/28105144/sesamin-attenuates-allergic-airway-inflammation-through-the-suppression-of-nuclear-factor-kappa-b-activation
#10
Liangchang Li, Hongmei Piao, Mingyu Zheng, Zhewu Jin, Liguang Zhao, Guanghai Yan
The aim of the present study is to determine the role of sesamin, the most abundant lignan in sesame seed oil, on the regulation of allergic airway inflammation in a murine asthma model. A BALB/c mouse model with allergic asthma was used to evaluate the effects of sesamin on nuclear factor-kappa B (NF-κB) activation. An enzyme-linked immunosorbent assay was used to determine protein expression in bronchoalveolar lavage (BAL) fluids. Hematoxylin and eosin staining was performed to examine histological changes...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28095736/development-of-multifunctional-foods
#11
REVIEW
Koji Yamada
Foods contain various biologically active substances with extent physiological effects. Among them, some substances, such as dietary fibers, polyunsaturated fatty acids, and antioxidants, exert multiple activities. In addition, combinational uses of some components, such as sesamin and α-tocopherol, enhance their biological effects each other. The expression of multiple effect leads to the production of multifunctional foods which prevent the occurrence of various diseases. Furthermore, synergic effects between biologically active substances allow us to decrease the dose of each component, which lead to the improvement of safety and reduction of production cost of multifunctional foods...
May 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28095362/in-vivo-modulation-of-lps-induced-leukotrienes-generation-and-oxidative-stress-by-sesame-lignans
#12
Puttaraju Srikantamurthy Yashaswini, Bettadahalli Sadashivaiah, Talahalli Ravichandra Ramaprasad, Sridevi Annapurna Singh
The role of inflammation and oxidative stress is critical during onset of metabolic disorders and this has been sufficiently established in literature. In the present study, we evaluated the effects of sesamol and sesamin, two important bioactive molecules present in sesame oil, on the generation of inflammatory and oxidative stress factors in LPS injected rats. Sesamol and sesamin lowered LPS induced expression of cPLA2 (61 and 56%), 5-LOX (44 and 51%), BLT-1(32 and 35%) and LTC4 synthase (49 and 50%), respectively, in liver homogenate...
December 29, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28040580/physiological-effects-of-%C3%AE-linolenic-acid-and-sesamin-on-hepatic-fatty-acid-synthesis-and-oxidation
#13
Takashi Ide, Haruka Iwase, Saaya Amano, Saki Sunahara, Ayuka Tachihara, Minako Yagi, Tsuyoshi Watanabe
Interrelated effects of γ-linolenic acid (GLA) and sesamin, a sesame lignan, on hepatic fatty acid synthesis and oxidation were examined. Rats were fed experimental diets supplemented with 0 or 2 g/kg sesamin (1:1 mixture of sesamin and episesamin) and containing 100 g/kg of palm oil (saturated fat), safflower oil rich in linoleic acid, or oil of evening primrose origin containing 43% GLA (GLA oil) for 18 days. In rats fed sesamin-free diets, GLA oil, compared with other oils, increased the activity and mRNA levels of various enzymes involved in fatty acid oxidation, except for some instances...
December 14, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27995494/effects-of-sesamin-on-chronic-stress-induced-anxiety-disorders-in-mice
#14
Ting Ting Zhao, Keon Sung Shin, Hyun Jin Park, Bo Ram Yi, Kyung Eun Lee, Myung Koo Lee
This study investigated the effects of (-)-sesamin on chronic electric footshock (EF) stress-induced anxiety disorders in mice. Mice were treated with (-)-sesamin (25 and 50 mg/kg) orally once a day for 21 days prior to exposure to EF stress (0.6 mA, 1 s every 5 s, 3 min). Mice treated with (-)-sesamin (25 and 50 mg/kg) exhibited less severe decreases in the number of open arm entries and time spent on open arms in the elevated plus-maze test and the distance traveled in the open field test following exposure to chronic EF stress...
December 19, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27991716/absorption-distribution-metabolism-and-excretion-of-14-c-sesamin-in-rats
#15
Namino Tomimori, Tomohiro Rogi, Hiroshi Shibata
SCOPE: Sesamin is a major lignan in sesame seeds and has various physiological effects. Although metabolism of sesamin by cytochrome P450 or intestinal microflora has been reported, little is known concerning the mass balance, pharmacokinetics and tissue distribution of sesamin. METHODS AND RESULTS: Absorption, distribution, metabolism and excretion of [(14) C]sesamin were investigated after a single oral dose of 5 mg/kg in rats. Sesamin was absorbed with peak plasma radioactivity at 1...
December 19, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27863411/sesamin-inhibits-il-1%C3%AE-stimulated-inflammatory-response-in-human-osteoarthritis-chondrocytes-by-activating-nrf2-signaling-pathway
#16
Pengyu Kong, Guanghua Chen, Anlong Jiang, Yufu Wang, Chengchao Song, Jinpeng Zhuang, Chunyang Xi, Guangxi Wang, Ye Ji, Jinglong Yan
Sesamin, a bioactive component extracted from sesame, has been reported to exert anti-inflammatory and anti-oxidant effects. In this study, we evaluated the anti-inflammatory effects of sesamin on IL-1β-stimulated human osteoarthritis chondrocytes and investigated the possible mechanism. Results demonstrated that sesamin treatment significantly inhibited PGE2 and NO production induced by IL-1β. Sesamin inhibited MMP1, MMP3, and MMP13 production in IL-1β-stimulated chondrocytes. Sesamin also inhibited IL-1β-induced phosphorylation of NF-κB p65 and IκBα...
December 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27789382/effects-of-sesamin-on-motor-and-memory-deficits-in-an-mptp-lesioned-mouse-model-of-parkinson-s-disease-treated-with-l-dopa
#17
T T Zhao, K S Shin, K S Kim, H J Park, H J Kim, K E Lee, M K Lee
The present study investigated the effects of (-)-sesamin on motor and memory deficits in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model of Parkinson's disease (PD) with l-3,4-dihydroxyphenylalanine (l-DOPA). MPTP-lesioned (30mg/kg/day, 5days) mice showed deficits in memory including habit learning memory and spatial memory, which were further aggravated by daily treatment with 25mg/kg l-DOPA for 21days. However, daily treatment with (-)-sesamin (25 and 50mg/kg) for 21days ameliorated memory deficits in an MPTP-lesioned mouse model of PD treated with l-DOPA (25mg/kg)...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27717829/effects-of-sesamin-on-chronic-stress-induced-memory-deficits-in-mice
#18
Ting Ting Zhao, Keon Sung Shin, Hyun Jin Park, Kyung Sook Kim, Kung Eun Lee, Yoon Jeong Cho, Myung Koo Lee
This study investigated the effects of (-)-sesamin on memory deficits induced by chronic electric footshock (EF)-induced stress in mice. Mice were treated with (-)-sesamin (25 and 50mg/kg, p.o., daily for 21day) prior to chronic EF stress (0.6mA, 1s every 5s for 3min, daily for 21day). Transfer retention latencies in the elevated plus maze test and N-methyl-d-aspartate (NMDA) receptor (type 1) phosphorylation in the hippocampus increased with chronic EF stress, and they were reduced by treatment with (-)-sesamin at both doses...
October 4, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27693952/simultaneous-quantification-and-identification-of-flavonoids-lignans-coumarin-and-amides-in-leaves-of-zanthoxylum-armatum-using-uplc-dad-esi-qtof-ms-ms
#19
Vinod Bhatt, Sushila Sharma, Neeraj Kumar, Upendra Sharma, Bikram Singh
The current study presents isolation and characterization of twelve compounds including catechin (1), isovitexin (2), hesperidin (3), psoralin (4), eudesmin (5), kobusin (6), fargesin (7), sesamin (8), asarinin (9), planispine-A (10), α-sanshool (11) and vitexin (12), from the leaves of Zanthoxylum armatum. Further, two rapid and simple ultra performance liquid chromatography-diode array detection (UPLC-DAD) methods were developed for the simultaneous quantitative determination of isolated compounds from Z...
January 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27669218/synergistic-anticancer-effect-of-tocotrienol-combined-with-chemotherapeutic-agents-or-dietary-components-a-review
#20
REVIEW
Takahiro Eitsuka, Naoto Tatewaki, Hiroshi Nishida, Kiyotaka Nakagawa, Teruo Miyazawa
Tocotrienol (T3), unsaturated vitamin E, is gaining a lot of attention owing to its potent anticancer effect, since its efficacy is much greater than that of tocopherol (Toc). Various factors are known to be involved in such antitumor action, including cell cycle arrest, apoptosis induction, antiangiogenesis, anti-metastasis, nuclear factor-κB suppression, and telomerase inhibition. Owing to a difference in the affinity of T3 and Toc for the α-tocopherol transfer protein, the bioavailability of orally ingested T3 is lower than that of Toc...
September 22, 2016: International Journal of Molecular Sciences
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