Xiaohuan Lu, Luming Xu, Yu Song, Xiangnan Yu, Qilin Li, Feng Liu, Xiaoqiong Li, Jiangbo Xi, Shuai Wang, Lin Wang, Zheng Wang
Postoperative peritoneal adhesion (PPA) is the most frequent complication after abdominal surgery. Current anti-adhesion strategies largely rely on the use of physical separating barriers creating an interface blocking peritoneal adhesion, which cannot reduce inflammation and suffers from limited anti-adhesion efficacy with unwanted side effects. Here, by exploiting the alternative activated macrophages to alleviate inflammation in adhesion development, a flexible graphene-composite-film (F-GCF) generating far-infrared (FIR) irradiation that effectively modulates the macrophage phenotype toward the anti-inflammatory M2 type, resulting in reduced PPA formation, is designed...
March 25, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)