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Adipocyte macrophage

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https://www.readbyqxmd.com/read/29449623/targeted-disruption-of-the-inos-gene-improves-adipose-tissue-inflammation-and-fibrosis-in-leptin-deficient-ob-ob-mice-role-of-tenascin-c
#1
S Becerril, A Rodríguez, V Catalán, L Méndez-Giménez, B Ramírez, N Sáinz, M Llorente, X Unamuno, J Gómez-Ambrosi, G Frühbeck
BACKGROUND/OBJECTIVES: Obesity is related to a dynamic extracellular matrix (ECM) remodeling, which involves the synthesis and degradation of different proteins, such as tenascin C (TNC) in the adipose tissue (AT). Given the functional relationship between leptin and inducible nitric oxide synthase (iNOS), our aim was to analyze the impact of the absence of the iNOS gene in AT inflammation and ECM remodeling in ob/ob mice. SUBJECTS/METHODS: The expression of genes involved in inflammation and ECM remodeling was evaluated in 10-week-old male double knockout (DBKO) mice simultaneously lacking the ob and iNOS genes as well as in ob/ob mice classified into three groups [control, leptin-treated (1 mg kg -1 day -1 ) and pair-fed]...
February 15, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29446826/1-3-6-7-tetrahydroxy-8-prenylxanthone-ameliorates-inflammatory-responses-resulted-in-by-the-paracrine-interaction-of-adipocytes-and-macrophages
#2
Dan Li, Qianyu Liu, Wen Sun, Xiuping Chen, Ying Wang, Yuxiang Sun, Ligen Lin
BACKGROUND AND PURPOSE: Chronic inflammation in adipose tissue is critical in the onset and development of insulin resistance and type 2 diabetes. Macrophage infiltration into adipose tissue and pro-inflammatory polarization play key roles in adipose tissue inflammation. The fruit hull of mangosteen (Garcinia mangostana) has been used in traditional medicine for treatment of various inflammatory diseases. However, its role in regulating adipose tissue inflammation is unexplored. This study was designed to identify xanthones from G...
February 15, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29445067/circulating-fatty-acid-binding-protein-4-concentration-predicts-the-progression-of-carotid-atherosclerosis-in-a-general-population-without-medication
#3
Masato Furuhashi, Satoshi Yuda, Atsuko Muranaka, Mina Kawamukai, Megumi Matsumoto, Marenao Tanaka, Norihito Moniwa, Hirofumi Ohnishi, Shigeyuki Saitoh, Kazuaki Shimamoto, Tetsuji Miura
BACKGROUND: Fatty acid-binding protein 4 (FABP4), which is expressed in both adipocytes and macrophages, is secreted from the cells and acts as an adipokine. An elevated circulating FABP4 level is associated with insulin resistance and atherosclerosis.Methods and Results:We investigated the causative association between FABP4 level and progression of atherosclerosis in subjects of the Tanno-Sobetsu Study, a population-based cohort. In 281 subjects without medication (male/female: 109/172) in the year 2010 or 2013, the carotid intima-media thickness (CIMT) assessed using carotid ultrasonography was significantly correlated with age, adiposity, blood pressure, renal dysfunction and levels of cholesterol, triglycerides, fasting glucose, HbA1c and FABP4 (r=0...
February 15, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29441065/adipocyte-fatty-acid-binding-protein-promotes-palmitate-induced-mitochondrial-dysfunction-and-apoptosis-in-macrophages
#4
Hui Li, Yang Xiao, Lin Tang, Feng Zhong, Gan Huang, Jun-Mei Xu, Ai-Min Xu, Ru-Ping Dai, Zhi-Guang Zhou
A high level of circulating free fatty acids (FFAs) is known to be an important trigger for macrophage apoptosis during the development of atherosclerosis. However, the underlying mechanism by which FFAs result in macrophage apoptosis is not well understood. In cultured human macrophage Thp-1 cells, we showed that palmitate (PA), the most abundant FFA in circulation, induced excessive reactive oxidative substance production, increased malondialdehyde concentration, and decreased adenosine triphosphate levels...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29437708/expression-of-adipocyte-macrophage-fatty-acid-binding-protein-in-tumor-associated-macrophages-promotes-breast-cancer-progression
#5
Jiaqing Hao, Fei Yan, Yuwen Zhang, Ashley Triplett, Ying Zhang, Debra A Schultz, Yanwen Sun, Jun Zeng, Kevin A T Silverstein, Qi Zheng, David A Bernlohr, Margot P Cleary, Nejat K Egilmez, Edward Sauter, Shujun Liu, Jill Suttles, Bing Li
Tumor associated macrophages (TAM) play a critical role in cancer development and progression. However, the heterogeneity of TAM presents a major challenge to identify clinically-relevant markers for pro-tumor TAM. Here, we report that expression of adipocyte/macrophage fatty acid binding protein (A-FABP) in TAM promotes breast cancer progression. While upregulation of A-FABP was inversely associated with breast cancer survival, deficiency of A-FABP significantly reduced mammary tumor growth and metastasis...
February 6, 2018: Cancer Research
https://www.readbyqxmd.com/read/29427237/differential-expression-of-lp-pla2-in-obesity-and-type-2-diabetes-and-the-influence-of-lipids
#6
Laura Jackisch, Warunee Kumsaiyai, Jonathan D Moore, Nasser Al-Daghri, Ioannis Kyrou, Thomas M Barber, Harpal Randeva, Sudhesh Kumar, Gyanendra Tripathi, Philip G McTernan
AIMS/HYPOTHESIS: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a circulatory macrophage-derived factor that increases with obesity and leads to a higher risk of cardiovascular disease (CVD). Despite this, its role in adipose tissue and the adipocyte is unknown. Therefore, the aims of this study were to clarify the expression of Lp-PLA2 in relation to different adipose tissue depots and type 2 diabetes, and ascertain whether markers of obesity and type 2 diabetes correlate with circulating Lp-PLA2...
February 9, 2018: Diabetologia
https://www.readbyqxmd.com/read/29426013/celecoxib-mediated-reduction-of-prostanoid-release-in-hoffa-s-fat-pad-from-donors-with-cartilage-pathology-results-in-an-attenuated-inflammatory-phenotype
#7
Ufuk Tan Timur, Marjolein M J Caron, Yvonne M Bastiaansen-Jenniskens, Tim J M Welting, L W van Rhijn, Gerjo J V M van Osch, Pieter J Emans
OBJECTIVE: The Hoffa's fat pad (HFP) is an intra-articular adipose tissue which is situated under and behind the patella. It contains immune cells next to adipocytes and secretes inflammatory factors during osteoarthritis (OA). In this study, we compared the release profile of prostanoids, which are involved in inflammation, of HFP from OA patients versus patients with a focal cartilage defect without evidence for OA on MRI and investigated the prostanoid modulatory anti-inflammatory action of celecoxib on HFP...
February 6, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29423731/hiv-persistence-in-adipose-tissue-reservoirs
#8
REVIEW
Jacob Couturier, Dorothy E Lewis
PURPOSE OF REVIEW: The purpose of this review is to examine the evidence describing adipose tissue as a reservoir for HIV-1 and how this often expansive anatomic compartment contributes to HIV persistence. RECENT FINDINGS: Memory CD4 T cells and macrophages, the major host cells for HIV, accumulate in adipose tissue during HIV/SIV infection of humans and rhesus macaques. Whereas HIV and SIV proviral DNA is detectable in CD4 T cells of multiple fat depots in virtually all infected humans and monkeys examined, viral RNA is less frequently detected, and infected macrophages may be less prevalent in adipose tissue...
February 9, 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29421992/metabolic-cooperation-between-cancer-and-non-cancerous-stromal-cells-is-pivotal-in-cancer-progression
#9
Filipa Lopes-Coelho, Sofia Gouveia-Fernandes, Jacinta Serpa
The way cancer cells adapt to microenvironment is crucial for the success of carcinogenesis, and metabolic fitness is essential for a cancer cell to survive and proliferate in a certain organ/tissue. The metabolic remodeling in a tumor niche is endured not only by cancer cells but also by non-cancerous cells that share the same microenvironment. For this reason, tumor cells and stromal cells constitute a complex network of signal and organic compound transfer that supports cellular viability and proliferation...
February 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29415997/downregulation-of-%C3%AE-1-4-galactosyltransferase-5-improves-insulin-resistance-by-promoting-adipocyte-commitment-and-reducing-inflammation
#10
Shu-Fen Li, Cui-Song Zhu, Yu-Meng Wang, Xin-Xin Xie, Liu-Ling Xiao, Zhi-Chun Zhang, Qi-Qun Tang, Xi Li
Protein glycosylation is an important post-translational modification. Aberrant glycosylation has been implicated in many diseases because of associated changes in protein distribution and biological function. We showed that the expression of β1, 4-galactosyltransferase 5 (B4GalT5) was positively correlated with diabetes and obesity. In vivo, B4GalT5 knockdown in subcutaneous adipose tissue alleviated insulin resistance and adipose tissue inflammation, and increased adipogenesis in high-fat diet (HFD)-fed mice and ob/ob mice...
February 7, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29410017/differential-response-to-caloric-restriction-of-retroperitoneal-epididymal-and-subcutaneous-adipose-tissue-depots-in-rats
#11
Takumi Narita, Masaki Kobayashi, Kaho Itakura, Rei Itagawa, Riho Kabaya, Yuka Sudo, Naoyuki Okita, Yoshikazu Higami
The beneficial actions of caloric restriction (CR) are partially mediated by metabolic remodeling of white adipose tissue (WAT). Recently, we showed that CR enhances de novo fatty acid (FA) biosynthesis and mitochondrial biogenesis, particularly in WAT. Here, to better understand the response of WAT to CR, we compare the effects of CR on three WAT depots in rats: retroperitoneal (rWAT), epididymal (eWAT) and subcutaneous (sWAT). Computed tomography and histological analysis showed that CR reduced the volume and average size of rWAT adipocytes...
February 1, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29409496/gold-nanoparticles-improve-metabolic-profile-of-mice-fed-a-high-fat-diet
#12
Hui Chen, Jane P M Ng, Yi Tan, Kristine McGrath, David P Bishop, Brian Oliver, Yik Lung Chan, Michael B Cortie, Bruce K Milthorpe, Stella M Valenzuela
BACKGROUND: Obesity is a high risk for multiple metabolic disorders due to excessive influx of energy, glucose and lipid, often from a western based diet. Low-grade inflammation plays a key role in the progression of such metabolic disorders. The anti-inflammatory property of gold compounds has been used in treating rheumatoid arthritis in the clinic. Previously we found that pure gold nanoparticles (AuNPs, 21 nm) also possess anti-inflammatory effects on the retroperitoneal fat tissue following intraperitoneal injection, by downregulating tumor necrosis factor (TNF) α...
February 6, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29407594/overexpression-of-perilipin1-protects-against-atheroma-progression-in-apolipoprotein-e-knockout-mice
#13
Kohei Yamamoto, Hideaki Miyoshi, Kyu Yong Cho, Akinobu Nakamura, Andrew S Greenberg, Tatsuya Atsumi
BACKGROUND AND AIMS: Perilipin1 (PLIN1), a lipid droplet-associated protein, plays an important role in the regulation of lipolysis and lipid storage in adipocytes. PLIN1 has recently been reported to be expressed in macrophages within atheroma plaques, suggesting PLIN1 may play a role in the accumulation of lipids at the arterial wall and in the development of atherosclerosis. To clarify the role of PLIN1 in the pathophysiology of atherosclerosis, we assessed the progression of atherosclerosis in PLIN1 transgenic mice (Plin1Tg)...
January 17, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29405636/dietary-curcumin-intervention-targets-mouse-white-adipose-tissue-inflammation-and-brown-adipose-tissue-ucp1-expression
#14
Zhuolun Song, Xavier Revelo, Weijuan Shao, Lili Tian, Kejing Zeng, Helena Lei, Hong-Shuo Sun, Minna Woo, Daniel Winer, Tianru Jin
OBJECTIVE: This study aimed to determine whether dietary curcumin intervention targets both white adipose tissue (WAT) inflammation and brown adipose tissue (BAT)-mediated energy expenditure. METHODS: C57BL/6J mice were fed with a low-fat diet, high-fat diet (HFD), or HFD plus curcumin. In addition to assessing the effect of curcumin intervention on metabolic profiles, this study assessed WAT macrophage infiltration and composition and inflammatory cytokine production...
February 6, 2018: Obesity
https://www.readbyqxmd.com/read/29393228/the-effect-of-a-high-fat-diet-on-the-development-of-abdominal-aortic-aneurysm-in-a-vascular-hypoperfusion-induced-animal-model
#15
Keisuke Hashimoto, Hirona Kugo, Hiroki Tanaka, Kazuko Iwamoto, Chie Miyamoto, Tetsumei Urano, Naoki Unno, Kohsuke Hayamizu, Nobuhiro Zaima, Tatsuya Moriyama
Abdominal aortic aneurysm (AAA) is a vascular disease characterized by chronic inflammation in the infrarenal aorta. Most cases of AAA remain asymptomatic until rupture, and the mortality rate of patients with AAA rupture is very high. Currently, the relation between dietary habits and AAA development remains unknown. In this study, we evaluated the effects of a high-fat diet on the development of AAA in a vascular hypoperfusion-induced animal model. The risk of AAA rupture and AAA diameter in the high-fat group significantly increased compared with those in the control group...
January 29, 2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29391544/adipocyte-specific-expression-of-c-type-natriuretic-peptide-suppresses-lipid-metabolism-and-adipocyte-hypertrophy-in-adipose-tissues-in-mice-fed-high-fat-diet
#16
Cho-Rong Bae, Jun Hino, Hiroshi Hosoda, Cheol Son, Hisashi Makino, Takeshi Tokudome, Tsutomu Tomita, Kiminori Hosoda, Mikiya Miyazato, Kenji Kangawa
C-type natriuretic peptide (CNP) is expressed in diverse tissues, including adipose and endothelium, and exerts its effects by binding to and activating its receptor, guanylyl cyclase B. Natriuretic peptides regulate intracellular cGMP and phosphorylated vasodilator-stimulated phosphoprotein (VASP). We recently revealed that overexpression of CNP in endothelial cells protects against high-fat diet (HFD)-induced obesity in mice. Given that endothelial CNP affects adipose tissue during obesity, CNP in adipocytes might directly regulate adipocyte function during obesity...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29388858/a-purification-technique-for-adipose-derived-stromal-cell-cultures-leads-to-a-more-regenerative-cell-population
#17
Renee F Conway, Kevin M Okarski, John A Szivek
It has been demonstrated that adipose-derived stromal cells (ASCs) are a regenerative cell population with potential uses for bone and cartilage regeneration. However, the biomarker expression and heterogeneity of the population has not been thoroughly characterized. By analyzing biomarker expression, we aimed to understand the composition of ASC populations extracted using a common extraction technique in comparison to ASC populations given an additional purification step. Human adipose tissue samples were collected, and ASCs were extracted from these samples using a common, published extraction technique (primary extraction)...
February 1, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29386559/adrenergic-hormones-induce-extrapituitary-prolactin-gene-expression-in-leukocytes-potential-implications-in-obesity
#18
Richard Barrett, Chandrakala Aluganti Narasimhulu, Sampath Parthasarathy
The pituitary hormone prolactin (PRL), originally described for its role in lactation, has been implemented in over 300 functions and is produced by multiple cell types outside of the pituitary. Monocyte/macrophages in particular show robust expression of extra-pituitary prolactin (ePRL). While ePRL protein is identical to pituitary PRL and translated from the same gene, tissues outside the pituitary engage an alternative promoter to regulate expression. Many of the factors regulating this expression, however, remain unknown...
January 31, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29377137/rab-10-a-traffic-controller-in-multiple-cellular-pathways-and-locations
#19
REVIEW
Christelle En Lin Chua, Bor Luen Tang
Rab GTPases are key regulators of eukaryotic membrane traffic, and their functions and activities are limited to particular intracellular transport steps and their membrane localization is by and large restricted. Some Rabs do participate in more than one transport steps, but broadly speaking, there is a clear demarcation between exocytic and endocytic Rabs. One Rab protein, Rab10, however, appears to be anomalous in this regard and has a diverse array of functions and subcellular localizations. Rab10 has been implicated in a myriad of activities ranging from polarized exocytosis and endosomal sorting in polarized cells, insulin-dependent Glut4 transport in adipocytes, axonal growth in neurons, and endo-phagocytic processes in macrophages...
January 27, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29374208/down-regulation-of-guanylate-binding-protein-1-causes-mitochondrial-dysfunction-and-cellular-senescence-in-macrophages
#20
Xiaoxue Qiu, Hong Guo, Junshu Yang, Yinduo Ji, Chia-Shan Wu, Xiaoli Chen
Macrophage polarization is tightly associated with its metabolic reprograming and immune dysfunction. However, the intracellular molecules/pathways that connect these alterations in inflammatory macrophages remain largely unidentified. Herein, we explored the role of guanylate binding protein 1 (Gbp1), an intracellular anti-microbial protein, in regulating polarization, metabolic reprogramming, and cellular aging of macrophages. We showed that Gbp1 expression in inguinal white adipose tissue is significantly decreased in high-fat diet -fed and aged mice...
January 26, 2018: Scientific Reports
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