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https://www.readbyqxmd.com/read/29667795/psychopharmacology
#1
Sahil Sekhon, George Kroumpouzos, John Koo
Most dermatologists evaluate and treat patients with psychological or psychiatric issues related to their skin disease. These patients often require psychopharmacologic therapies. Therefore, it is important for dermatologists to be familiar about psychopharmacologic treatments for diseases that fit into the overlap between psychiatry and dermatology. This review aims to provide a concise overview of psychopharmacology as it applies to dermatology. Psychotropic medications commonly used in psychodermatology, including antidepressants, antipsychotics, and anxiolytics, are reviewed; safety profile and dosing recommendations are discussed...
April 18, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29667728/comparison-of-10-efficient-protocols-for-photodynamic-therapy-of-actinic-keratosis-how-relevant-are-effective-light-dose-and-local-damage-in-predicting-the-complete-response-rate-at-3-months
#2
Anne-Sophie Vignion-Dewalle, Gregory Baert, Elise Thecua, Fabienne Lecomte, Claire Vicentini, Henry Abi-Rached, Laurent Mortier, Serge Mordon
BACKGROUND: Topical photodynamic therapy is an established treatment modality for various dermatological conditions, including actinic keratosis. In Europe, the approved protocols for photodynamic therapy of actinic keratosis involve irradiation with either an Aktilite CL 128 lamp or daylight, whereas irradiation with the Blu-U illuminator is approved in the United States. Many other protocols using irradiation by a variety of light sources are also clinically efficient. OBJECTIVES: This paper aims to compare 10 different protocols with clinically proven efficacy for photodynamic therapy of actinic keratosis and the available spectral irradiance of the light source...
April 18, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29665741/lymphomatoid-papulosis-presenting-as-a-rash-in-a-patient-with-hiv-infection
#3
Sian Warren, Vincent Li, Rachel Drayton, Kenneth May
A 43-year-old Malaysian man with well-controlled HIV infection on combination antiretroviral therapy presented with a six-week history of a widespread rash. The patient was otherwise well but was developing new lesions on a daily basis. Referral to Dermatology instigated punch biopsies, which revealed a diagnosis of lymphomatoid papulosis type A. This case highlights the importance of swift referral, especially in cases of spontaneous regression of symptoms, in order to obtain the correct diagnosis. In most patients, this condition tends to be chronic, with its chronicity and benign clinical course setting it apart from cutaneous anaplastic T-cell lymphoma and Hodgkin's disease, which are major entities in the histological differential diagnosis...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29665511/advanced-cutaneous-squamous-cell-carcinoma-a-retrospective-analysis-of-patient-profiles-and-treatment-patterns-results-of-a-non-interventional-study-of-the-decog
#4
Uwe Hillen, Ulrike Leiter, Sylvie Haase, Roland Kaufmann, Jürgen Becker, Ralf Gutzmer, Patrick Terheyden, Albrecht Krause-Bergmann, Hans-Joachim Schulze, Jessica Hassel, Nina Lahner, Uwe Wollina, Fabian Ziller, Jochen Utikal, Christine Hafner, Jens Ulrich, Hans-Günther Machens, Carsten Weishaupt, Axel Hauschild, Peter Mohr, Claudia Pföhler, Jan Maurer, Patrick Wolff, Christine Windemuth-Kieselbach, Dirk Schadendorf, Elisabeth Livingstone
BACKGROUND: Advanced cutaneous squamous cell carcinoma (aSCC) is an area of unmet medical need and no treatment standards are established. Recently, an anti-PD-1 inhibitor received FDA breakthrough therapy designation. The aim of the study was to describe the clinical course, therapeutic management and prognosis of aSCC under real-life conditions. PATIENTS AND METHODS: In a retrospective study performed in 24 German and Austrian hospitals and doctor's offices, patient and tumour characteristics of patients diagnosed with aSCC between January 1, 2010 and December 31, 2011 and their disease course was documented...
April 14, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29665030/dermatologic-toxicity-from-novel-therapy-using-antimicrobial-peptide-ll-37-in-melanoma-a-detailed-examination-of-the-clinicopathologic-features
#5
Tsetan Dolkar, Celestine M Trinidad, Kelly C Nelson, Rodabe N Amaria, Priyadharsini Nagarajan, Carlos A Torres-Cabala, Doina Ivan, Victor G Prieto, Michael T Tetzlaff, Jonathan L Curry, Phyu P Aung
LL-37 is a naturally occurring 37-amino acid that is part of innate immunity in human skin. Preclinical studies have demonstrated that intra-tumoral injections of LL-37 stimulate the innate immune system by activation of plasmacytoid dendritic cells, which mediate tumor destruction. LL-37 intra-tumoral injections have been utilized in a Phase 1 clinical trial for melanoma patients with cutaneous metastases. We report dermatologic toxicity in a 63-year-old woman with stage IIIC melanoma of the right calf and inguinal lymph nodes...
April 17, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29663335/long-term-efficacy-of-add-on-lacosamide-treatment-in-children-and-adolescents-with-refractory-epilepsies-a-single-center-observational-study
#6
Anna Rosati, Lucrezia Ilvento, Riccardo Rizzi, Viola Doccini, Maria Carmela Leo, Alessandra Pugi, Salvatore De Masi, Renzo Guerrini
OBJECTIVE: To assess long-term efficacy and tolerability of lacosamide (LCM) as adjunctive treatment through a retrospective study in children and adolescents with refractory epilepsies. METHODS: All patients consecutively treated with LCM as add-on for refractory focal and generalized epilepsy and followed at the Neuroscience Center of Excellence of the Meyer Children's Hospital of Florence between January 2011 and September 2015 were included in the study. Responder rate, relapse-free survival, and retention rate were calculated...
April 17, 2018: Epilepsia
https://www.readbyqxmd.com/read/29650685/osimertinib-a-novel-dermatologic-adverse-event-profile-in-patients-with-lung-cancer
#7
Chia-Yu Chu, Jennifer Choi, Beth Eaby-Sandy, Corey J Langer, Mario E Lacouture
Dermatologic adverse events (dAEs) are common with the use of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy. First- and second-generation agents (erlotinib, gefitinib, and afatinib) are frequently associated with acneiform rash, pruritus, xerosis, and paronychia; the incidence and characterization of these dAEs have been well described. However, there is evidence that the dAE profile is different with third-generation EGFR-TKIs. Herein, we describe the dAEs associated with third-generation EGFR-TKIs and our clinical experience with osimertinib, a third-generation EGFR-TKI approved by the U...
April 12, 2018: Oncologist
https://www.readbyqxmd.com/read/29649923/diffuse-dermatophytosis-occurring-on-dimethyl-fumarate-therapy
#8
Jeffrey I Greenstein
BACKGROUND: Opportunistic infections have occurred during dimethyl fumarate (DMF) therapy. OBJECTIVE: Diffuse skin dermatophytosis which occurred during DMF therapy in the setting of lymphopenia is described. METHODS AND RESULTS: The clinical course, the lymphocyte subset profile, and dermatologic evaluations were reviewed. In both instances, there was no other cause of lymphopenia or immune suppression, and it is likely that the tinea infections are associated with DMF therapy...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29645394/cicatricial-alopecia
#9
Varvara Kanti, Joachim Röwert-Huber, Annika Vogt, Ulrike Blume-Peytavi
In the classification of the North American Hair Research Society, primary cicatricial alopecias (PCA) are divided into four groups according to their prominent inflammatory infiltrate: PCAs with lymphocytic, neutrophilic, mixed or nonspecific cell inflammation pattern. The hair loss can begin subclinically and progress slowly so that the exact onset of the disease is often difficult to determine. The diagnosis is often delayed. While most forms of cicatricial alopecia can be clearly diagnosed based on clinical presentation in the acute disease stage, diagnosis can be challenging in the subacute, early or late disease stages...
April 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29630148/representation-and-treatment-allocation-of-racial-groups-in-dermatologic-therapy-trials-a-2-year-review-of-the-literature
#10
Christina K Park, Raed Alhusayen
Although most investigators would agree that including minority races in clinical trials is important, recruitment and retention may differ among these populations. The objective of this review was to perform an audit of phase III dermatologic therapy trials to determine representation for minority groups and to explore the possibility of racial allocation bias. In this review of 11 dermatology or general medicine journals in 2015-16, we did not find evidence of systemic racial allocation bias. We did however note variation in the proportion of minority races included in studies; whereas some trials had high success in recruiting minorities, many did not...
February 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29623021/biochemical-aspects-of-mammalian-melanocytes-and-the-emerging-role-of-melanocyte-stem-cells-in-dermatological-therapies
#11
REVIEW
Sharique A Ali, Ishrat Naaz
Skin color in animals is richer than human beings and is determined by different types of pigments. Melanin is the key pigment responsible for the diverse pigmentation found in animal and human skin, hair, and eyes. Melanin pigment is synthesized by melanocytes and is consecutively transferred to adjacent keratinocytes; here, it acts as an internal sunscreen to defend from ultraviolet (UV) damage. Any defect in the process of melanocytes development and/or melanin synthesis results in esthetic problem of abnormal pigmentation...
January 2018: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29614137/treating-to-target-a-realistic-goal-in-psoriasis
#12
Kenneth B Gordon, April W Armstrong, M Alan Menter, Jashin J Wu
For many patients, the new biologic therapies for psoriasis can improve Psoriasis Area and Severity Index (PASI) scores in a relatively short time. But when results are less than optimal, patients often become frustrated. By providing effective medical treatment using a treat-to-target strategy, clinicians can relieve symptoms and halt disease progression. Although body surface area (BSA) and PASI scores are appropriate for analyzing results of clinical trials, clinicians need to use more patient-centered assessments of patients' progress such as the Dermatology Life Quality Index (DLQI) and Psoriasis Symptom Inventory (PSI), as well as other validated patientreported outcomes, which can enable them to set realistic and achievable goals for individual patients...
February 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29610684/immune-toxicity-with-checkpoint-inhibition-for-metastatic-melanoma-case-series-and-clinical-management
#13
Anna J Lomax, Jennifer Lim, Robert Cheng, Arianne Sweeting, Patricia Lowe, Neil McGill, Nicholas Shackel, Elizabeth L Chua, Catriona McNeil
Immune checkpoint inhibitors (anti-PD-1 and anti-CTLA-4 antibodies) are a standard of care for advanced melanoma. Novel toxicities comprise immune-related adverse events (irAE). With increasing use, irAE require recognition, practical management strategies, and multidisciplinary care. We retrospectively evaluated the incidence, kinetics, and management of irAE in 41 patients receiving anti-PD-1 antibody therapy (pembrolizumab) for advanced melanoma. 63% received prior anti-CTLA-4 antibody therapy (ipilimumab)...
2018: Journal of Skin Cancer
https://www.readbyqxmd.com/read/29610017/epidermal-barrier-and-oxidative-stress-parameters-improve-during-in-311-nm-narrow-band-uvb-phototherapy-of-plaque-type-psoriasis
#14
Razvigor Darlenski, Evgeniya Hristakieva, Ufuk Aydin, Desisslava Gancheva, Tanya Gancheva, Antoaneta Zheleva, Veselina Gadjeva, Joachim W Fluhr
BACKGROUND: Psoriasis is a multi-systemic inflammatory disease that results from dysregulation between epidermal keratinocyte homeostasis and both innate and acquired immunity. Epidermal barrier defect has been described in psoriatic lesions. Furthermore an imbalance between pro-oxidative stress and antioxidant defense mechanisms are known in psoriasis patients. AIM: The aim of this study was to address the link between disease activity, epidermal barrier and systemic oxidative stress in the course of 311 nm narrow band ultraviolet B (NB-UVB) therapy of psoriasis...
March 21, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29607625/turmeric-tonic-as-a-treatment-in-scalp-psoriasis-a-randomized-placebo-control-clinical-trial
#15
Parichehr Bahraini, Mehdi Rajabi, Parvin Mansouri, Golnaz Sarafian, Reza Chalangari, Zahra Azizian
BACKGROUND: Psoriasis is an autoimmune and recurrent chronic inflammatory skin disorder with a strong genetic basis. The characteristic features are hyperproliferation of keratinocytes, leading to redness, thickening, and scaling of the epidermis followed by itching and the appearance of lesions, which in most cases can affect the patients both medically and psychologically. The scalp is one of the most common sites for psoriasis. This condition is predominantly managed with steroids, which are associated with various side effects...
April 1, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29607377/targeted-therapy-induced-facial-skin-toxicities-impact-on-quality-of-life-in-cancer-patients
#16
Kaori Yagasaki, Hiroko Komatsu, Kenzo Soejima, Katsuhiko Naoki, Ichiro Kawada, Hiroyuki Yasuda, Yasuo Hamamoto
Objective: Targeted therapy-induced facial skin toxicities may reduce overall quality of life (QoL) in cancer patients. We investigated whether facial skin toxicities affect QoL and attempted to identify factors related to QoL in patients with advanced/recurrent cancer. Methods: We performed a cross-sectional study in 34 outpatients with advanced/recurrent cancer showing targeted therapy-induced facial skin toxicities in Japan between November 2016 and February 2017...
April 2018: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29604225/bedside-reasoning-on-causes-and-mechanisms-of-diseases-in-the-era-of-precision-medicine-a-timeless-story
#17
REVIEW
Dan Lipsker
This is a short reflection about bedside reasoning in clinical medicine, emphasizing the importance of distinguishing between causes and mechanisms of diseases. All complex/sporadic diseases result from interactions between a genetic predisposition and environmental factors. The main disease mechanisms resulting in clinical signs involve inflammation, insult of vessels or nerves, pharmacological or hormonal dysfunction, altered metabolism and overload, tumoral proliferations, intrinsic dysfunction, malformation and traumatism...
March 31, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29603761/an-experimental-investigation-of-a-novel-iron-chelating-protoporphyrin-ix-prodrug-for-the-enhancement-of-photodynamic-therapy
#18
Lizette Anayo, Anette Magnussen, Alexis Perry, Mark Wood, Alison Curnow
OBJECTIVES: Non-melanoma skin cancers are the most frequently occurring type of cancer worldwide. They can be effectively treated using topical dermatological photodynamic therapy (PDT) employing protoporphyrin IX (PpIX) as the active photosensitising agent as long as the disease remains superficial. Novel iron chelating agents are being investigated to enhance the effectiveness and extend the applications of this treatment modality, as limiting free iron increases the accumulation of PpIX available for light activation and thus cell kill...
March 31, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29603108/should-open-excisions-and-sutured-incisions-be-treated-differently-a-review-and-meta-analysis-of-animal-wound-models-following-low-level-laser-therapy
#19
Peter Gál, Martin Bjørn Stausholm, Ivan Kováč, Erik Dosedla, Ján Luczy, František Sabol, Jan Magnus Bjordal
Although low-level laser therapy (LLLT) was discovered already in the 1960s of the twentieth century, it took almost 40 years to be widely used in clinical dermatology/surgery. It has been demonstrated that LLLT is able to increase collagen production/wound stiffness and/or improve wound contraction. In this review, we investigated whether open and sutured wounds should be treated with different LLLT parameters. A PubMed search was performed to identify controlled studies with LLLT applied to wounded animals (sutured incisions-tensile strength measurement and open excisions-area measurement)...
March 30, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29602922/indicators-of-phagocytosis-in-women-with-acne-during-comprehensive-treatment-that-included-immunotherapy-and-probiotics
#20
Orysya О Syzon, Marianna О Dashko
OBJECTIVE: Introduction: Acne is one of the most common dermatological diseases. It may have a chronic course, leaving permanent marks, and in last years has been tending to have more and more severe clinical course with widespread skin lesions. According to recent studies, the development of acne is due to the combined effect of endogenous and exogenous factors, among which endocrine diseases (quite a significant aspect), disorders of metabolic processes, reduced systemic immunity and phagocytic ability of mononuclear phagocytes and granulocytes at various stages of phagocytosis of pyogenic cocci, which contributes to more severe clinical course, and frequent relapse of this diseases...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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