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https://www.readbyqxmd.com/read/29231502/-clinical-observation-of-chronic-perianal-eczema-treated-with-auricular-point-sticking-therapy-and-western-medication
#1
Yong Wen, Jun Li, Qing Long, Chuan Wan, Xiaolin Lan, Ye Chen
OBJECTIVE: To observe the differences in the therapeutic effects on chronic perianal eczema between auricular point sticking therapy and auricular sticking pseudo-press therapy on the basis of the treatment with western medication. METHODS: Ninety patients were randomized into an auricular therapy group and an auricular pseudo-press therapy group (pseudo group), 45 cases in each one. The western medication was used in both of the groups. In the auricular therapy group, the auricular sticking method with semen vaccariae was added at Fengxi (SF1,zi), Shenshangxian (TG2p), Duipingjian (AT1,2,4i), Fei (CO14), Pi (CO13), Gangmen (HX5)...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231446/-the-indications-of-acupuncture-moxibustion-in-china-state-compiled-textbooks
#2
Weijuan Gang, Xiaodong Wu, Fang Wang, Xin Wang
The Acupuncture-moxibustion and Acupuncture-moxibustion therapy have been the state-compiled textbooks of acupuncture-moxibustion in colleges and universities of TCM for nearly more than half a century, which play a regulating and guiding role for acupuncture education and to a certain extent represent the development status of this discipline. The indications included in Acupuncture-moxibustion from 1th edition to 7th edition and Acupuncture-moxibustion therapy from 1th edition to 3rd edition were analyzed in this study, which was aimed to basically reflect the current situation of acupuncture indications...
March 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29230387/hyperpigmentation-of-the-hard-palate-mucosa-in-a-patient-with-chronic-myeloid-leukaemia-taking-imatinib
#3
Gian Paolo Bombeccari, Umberto Garagiola, Francesco Pallotti, Margherita Rossi, Massimo Porrini, Aldo Bruno Giannì, Francesco Spadari
Background: Imatinib mesylate is an inhibitor of the tyrosine kinase Bcr-Abl and a first-line treatment for Philadelphia chromosome-positive chronic myeloid leukaemia (CML). Dermatological side effects include superficial oedema, pustular eruption, lichenoid reactions, erythroderma, and skin rash. Depigmentation of the skin and/or mucosa is uncommon, and hyperpigmentation is rare. Case presentation: We present the case of a 63-year-old Caucasian male with widespread hyperpigmentation of the hard palate associated with a 9-year history of imatinib therapy to treat CML...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29228499/high-dose-intravenous-immunoglobulins-for-the-treatment-of-dermatological-autoimmune-diseases
#4
Jochen H O Hoffmann, Alexander H Enk
Based on their immunomodulatory properties, high-dose intravenous immunoglobulins (IVIGs) are successfully used in the treatment of various dermatological autoimmune diseases, in particular pemphigus vulgaris and dermatomyositis. In autoimmune bullous diseases, IVIGs can be used in an adjuvant setting (second- or third-line therapy) once combined immunosuppressive regimens have failed. In dermatomyositis, IVIGs may already be employed as an adjuvant second-line therapy after failure of corticosteroid monotherapy...
December 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29228470/melanoma-patterns-of-care-in-ontario-a-call-for-a-strategic-alignment-of-multidisciplinary-care
#5
Nicole J Look Hong, Stephanie Y Cheng, Nancy N Baxter, Frances C Wright
BACKGROUND AND OBJECTIVES: Variability in melanoma management has prompted concerns about equitable and timely treatment. We investigated patterns of melanoma diagnosis and treatment using population-level data. METHODS: Patients with invasive cutaneous melanoma were identified retrospectively from the Ontario Cancer Registry (2003-2012) and deterministically linked with administrative databases to identify incidence, disease characteristics, geographic origin, and multimodal treatment within a year of diagnosis...
December 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29224199/paradoxical-psoriasiform-reactions-of-anti-tumour-necrosis-factor-therapy-in-inflammatory-bowel-disease-patients
#6
Faseeha C Peer, Andrew Miller, Paul Pavli, Kavitha Subramaniam
Anti-tumour necrosis factor (TNF) agents have demonstrated efficacy in inflammatory bowel disease (IBD). Cutaneous reactions such as new onset psoriasis or psoriasiform-like reactions are among the most common adverse reactions. We retrospectively identified cases of anti-TNF-induced psoriasis or psoriasiform manifestations in IBD patients at a tertiary centre in Australia. A total of 10 (six females) of 270 (3.7%) IBD patients treated with anti-TNF therapy developed drug-induced psoriatic or psoriasiform-like reactions: five patients were treated with infliximab and five with adalimumab; nine had Crohn disease...
December 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29207818/clinical-efficacy-and-safety-on-combining-20-trichloroacetic-acid-peel-with-topical-5-ascorbic-acid-for-melasma
#7
Surabhi Dayal, Priyadarshini Sahu, Manoj Yadav, V K Jain
Introduction: Trichloroacetic Acid (TCA) is a versatile peeling agent for treatment of melasma. However, Post-Inflammatory Hyperpigmentation (PIH) is reported to be the most common side-effect associated with TCA peel. Topical Ascorbic Acid (AA) due to its effect as antioxidant and tyrosinase inhibitor helps to prevent PIH and maintains the response. Aim: To assess the clinical efficacy, safety and reduction in Melasma Quality of Life (MELASQOL) on combining 20% TCA peel with 5% ascorbic acid cream in epidermal melasma...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29204427/natural-killer-cells-activity-in-a-metastatic-colorectal-cancer-patient-with-complete-and-long-lasting-response-to-therapy
#8
Alessandro Ottaiano, Maria Napolitano, Monica Capozzi, Salvatore Tafuto, Antonio Avallone, Stefania Scala
Here we report a case of a 70-year-old man who received adjuvant chemotherapy with fluorouracile, folinic acid and oxaliplatin after a left hemicolectomy for a stage IIIb adenocarcinoma in May 2009. During follow-up he de-veloped abdominal lymphnodes metastases evidenced by positron emission tomography- computed tomography (PET-CT) scan and increase of carcinoembryonic antigen (CEA) level. Chemotherapy with capecitabine, oxaliplatin and bevacizumab was started in April 2012. Restaging showed a complete response and normalization of CEA...
November 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29202605/toxic-epidermal-necrolysis-spectrum-management-at-sunnybrook-health-sciences-centre-our-multidisciplinary-approach-after-review-of-the-current-evidence
#9
Alexandra Mereniuk, Alejandra Jaque, Marc G Jeschke, Neil H Shear
Toxic epidermal necrolysis spectrum (TENS) is a rare yet severe adverse drug reaction associated with a high mortality rate. Beyond supportive care, there is still no established therapy for TENS, although recent meta-analyses and UK guideline recommendations have attempted to offer a review of relevant literature on this difficult topic. As most directed treatments lack clear consensual evidence, care centres often resort to establishing their own strategies. As Canada's largest adult burn centre and the provincial reference centre for most burn patients in Ontario, our team at the Ross Tilley Burn Centre, in collaboration with the Department of Dermatology at Sunnybrook Health Sciences Centre, Toronto, Canada, has managed over 60 confirmed cases of TENS over the past 2 decades...
December 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29200755/current-and-future-perspectives-of-stem-cell-therapy-in-dermatology
#10
REVIEW
Christine M Prodinger, Julia Reichelt, Johann W Bauer, Martin Laimer
Stem cells are undifferentiated cells capable of generating, sustaining, and replacing terminally differentiated cells and tissues. They can be isolated from embryonic as well as almost all adult tissues including skin, but are also generated through genetic reprogramming of differentiated cells. Preclinical and clinical research has recently tremendously improved stem cell therapy, being a promising treatment option for various diseases in which current medical therapies fail to cure, prevent progression or relieve symptoms...
December 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/29197220/allergic-and-non-allergic-skin-reactions-associated-with-growth-hormone-therapy-elucidation-of-causative-agents
#11
Shilpa Mehta, Vikash Oza, Renee Potashner, Patricia Zamora, Manish Raisingani, Bina Shah
BACKGROUND: Allergic and non-allergic skin reactions to recombinant human growth hormone (rhGH) are uncommon and infrequently reported. However, physicians should be aware of these potential side effects to determine whether the reactions constitute true allergies and how to proceed with growth hormone therapy. To review allergic and non-allergic skin reactions caused by rhGH and subsequent diagnostic workup and management options. CASE PRESENTATION: We report the case of a 12-year-old healthy male presenting with idiopathic short stature...
December 2, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29194786/microneedling-for-the-treatment-of-hair-loss
#12
REVIEW
Raymond M Fertig, A Caresse Gamret, Jessica Cervantes, Antonella Tosti
Microneedling is a minimally invasive dermatological procedure in which fine needles are rolled over the skin to puncture the stratum corneum. This therapy is used to induce collagen formation, neovascularization, and growth factor production of treated areas. It has been used in a wide range of dermatologic conditions, including androgenetic alopecia and alopecia areata, among others. While there are a limited number of studies examining this therapy in the use of hair loss, microneedling has been successfully paired with other hair growth promoting therapies, such as minoxidil, platelet rich plasma, and topical steroids, and shown to stimulate hair follicle growth...
December 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29194677/chronic-inflammatory-demyelinating-polyneuropathy-and-malignancy-a-systematic-review
#13
REVIEW
Yusuf A Rajabally, Shahram Attarian
A systematic review of the literature was performed on the association of chronic inflammatory demyelinating polyneuropathy (CIDP) with malignancy. Hematologic disorders are the most common association, particulalry non-Hodgkin's lymphoma. CIDP frequently precedes the malignancy diagnosis, and there is a favorable CIDP response to treatment more than 70% of the time. Melanoma is the second most common association, and may be accompanied by antiganglioside antibodies; the CIDP shows a good response to immunotherapy...
December 1, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29171925/clinical-and-photobiological-response-in-eight-patients-with-solar-urticaria-under-treatment-with-omalizumab-and-review-of-the-literature
#14
D Morgado-Carrasco, X Fustà-Novell, S Podlipnik, A Combalia, P Aguilera
BACKGROUND: Solar urticaria (SU) is a rare photodermatosis. Treatment is challenging and outcomes are often disappointing. Omalizumab is an anti-IgE, currently approved for treatment of chronic spontaneous urticaria. We sought to evaluate therapy with omalizumab in refractory SU and describe predictive factors for response. MATERIALS/METHODS: Patients with refractory SU under treatment with omalizumab were included in this study. Clinical outcome was evaluated using the Urticaria Activity score 7 (UAS7), Dermatology Life Quality Index (DLQI) and Pruritus Visual Analogue scale (VAS)...
November 24, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29167858/cutaneous-squamous-cell-carcinomas-in-solid-organ-transplant-recipients-compared-with-immunocompetent-patients
#15
Joyce Y Cheng, Fang-Yong Li, Christine J Ko, Oscar R Colegio
Importance: Solid organ transplant recipients (SOTRs) have a 100-fold increased risk of squamous cell carcinoma (SCC), and they may develop more aggressive SCCs compared with immunocompetent individuals. Objective: To compare outcomes associated with aggressive behavior of SCC in SOTRs and high-risk immunocompetent patients. Design, Setting, and Participants: A retrospective cohort study of 58 SOTRs and 40 immunocompetent patients evaluated at the Yale Transplant Dermatology Clinic in New Haven, Connecticut, who had at least 1 SCC confirmed histopathologically between January 1, 2008, and December 31, 2015...
November 22, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29166499/skin-disorders-in-renal-transplant-recipients-a-retrospective-study
#16
Pedro Miguel Clemente Garrido, João Borges-Costa
BACKGROUND: Immunosuppressive therapy, which is necessary to avoid graft rejection in renal transplant recipients, presents an increased risk of several pathologies, namely infectious and neoplastic. OBJECTIVES: To identify the most frequent skin diseases and their clinical and demographical risk factors within a population of renal transplant recipients. METHODS: A retrospective study of renal transplant recipients referred to dermatology visit and observed for the first time from January 2008 to December 2014...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29154501/challenges-to-laser-assisted-drug-delivery-applying-theory-to-clinical-practice
#17
Omer Ibrahim, Emily Wenande, Sara Hogan, Kenneth A Arndt, Merete Haedersdal, Jeffrey S Dover
BACKGROUND: The percutaneous penetration of topically applied compounds can be enhanced using external chemical or physical sources and thus laser-assisted drug delivery is a burgeoning area of interest within the field of dermatology. OBJECTIVES: This article briefly discusses the mechanism of laser-assisted drug delivery and expands upon the challenges and safety issues that may arise in the clinical implementation of this modality. RESULTS: The existing literature demonstrates that investigators and clinicians in dermatology have successfully delivered anti-inflammatory, anti-neoplastic, and anti-oxidative medications transdermally for the treatment of a variety of conditions including scarring, photoageing, and cutaneous neoplasia...
November 20, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29152725/regressed-melanocytic-nevi-secondary-to-pembrolizumab-therapy-an-emerging-melanocytic-dermatologic-effect-from-immune-checkpoint-antibody-blockade
#18
Shakuntala H Mauzo, Michael T Tetzlaff, Kelly Nelson, Rodabe Amaria, Sapna Patel, Phyu P Aung, Priyadharsini Nagarajan, Carlos A Torres-Cabala, Adi Diab, Victor G Prieto, Jonathan L Curry
BACKGROUND: Immune checkpoint antibody blockade is an emerging therapeutic option for treating certain cancers including melanoma. This therapy is associated with dermatologic and systemic toxicities, some of which are more severe than others and may require withholding therapy. CASE REPORTS: We report two patients with melanocytic nevi that regressed with pembrolizumab therapy. The first patient had stage IV BRAF K601E/L584F mutant melanoma that developed a regressed melanocytic nevus while being treated with pembrolizumab...
November 20, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29150768/toe-web-intertrigo-in-kaposi-s-sarcoma-patients-a-microbiological-study-in-a-large-cohort-of-patients
#19
G Nazzaro, A Tourlaki, B Scoppio, A Restelli, A Grancini, L Brambilla
Kaposi 's sarcoma (KS) is a rare multifocal angioproliferative disease associated with human herpes virus 8 (HHV-8) infection, characterized by cutaneous nodules or plaques especially on the lower limbs. Some skin modifications, such as chronic lymphedema, plantar hyperkeratosis and interdigital desquamation, may be associated with consequent impairment of the local immunosurveillance and increased risk of some bacterial or mycotic infections. With the objective of evaluating if bacterial or mycotic infections in KS patients are supported by different microorganisms compared to control patients, we performed an observational retrospective study, comparing positive cultural swabs of interdigital intertrigo of KS patients with positive cultural swabs of interdigital intertrigo of patients admitted to our dermatologic unit during the last 10 years...
November 17, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29150291/ruxolitinib-conjugated-gold-nanoparticles-for-topical-administration-an-alternative-for-treating-alopecia
#20
Sanda Boca, Cristian Berce, Ancuta Jurj, Bobe Petrushev, Laura Pop, Grigore-Aristide Gafencu, Sonia Selicean, Vlad Moisoiu, Daiana Temian, Wilhelm-Thomas Micu, Simion Astilean, Cornelia Braicu, Ciprian Tomuleasa, Ioana Berindan-Neagoe
Alopecia is a dermatological condition for which Janus kinase (JAK) inhibitors have recently emerged as potential therapy options, but with limited practical use because of the systemic side effects. The topical use of Ruxolitinib in alopecia universalis has been demonstrated, but little is known about the pharmacodynamics and pharmacokinetics of this way of administration. Nanomedicine provides improved therapeutics. In the current paper we present preliminary data regarding the potential use of Ruxolitinib-conjugated gold nanoparticles (GNPs) in dermatological conditions, as GNPs have been proven to have a reduced absorption rate into the systemic blood flow for cutaneous administration...
November 2017: Medical Hypotheses
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