keyword
MENU ▼
Read by QxMD icon Read
search

Celiac microbiota

keyword
https://www.readbyqxmd.com/read/28340001/early-life-origin-of-intestinal-inflammatory-disorders
#1
Delphine Ley, Jean-Luc Desseyn, Mona Mischke, Jan Knol, Dominique Turck, Frédéric Gottrand
A growing body of evidence supports the concept of perinatal programming through which the perinatal environment affects the development of the fetus and infant, thereby modifying the risk profile for disease later in life. Increasing attention is focusing on the role of the early environment in the development of chronic intestinal disorders. Epidemiological studies have highlighted the link between perinatal factors, such as breastfeeding, cesarean delivery, and antibiotic use, and an increased risk for inflammatory bowel disease and/or celiac disease...
March 7, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28324102/duodenal-mucosa-of-patients-with-type-1-diabetes-shows-distinctive-inflammatory-profile-and-microbiota
#2
Silvia Pellegrini, Valeria Sordi, Andrea Mario Bolla, Diego Saita, Roberto Ferrarese, Filippo Canducci, Massimo Clementi, Francesca Invernizzi, Alberto Mariani, Riccardo Bonfanti, Graziano Barera, Pier Alberto Testoni, Claudio Doglioni, Emanuele Bosi, Lorenzo Piemonti
Context: Increasing evidences suggest a correlation between gut and type 1 diabetes (T1D). Objective: The objective of this study is to evaluate the gut inflammatory profile and microbiota in patients with T1D, compared to healthy controls (CTRL) and patients with celiac disease (CD) as gut inflammatory disease controls. Design/Setting/Participants: The inflammatory status and microbiome composition were evaluated in biopsies of the duodenal mucosa of patients with T1D (n=19), CD (n=19) and CTRL (n=16), recruited at San Raffaele Scientific Institute, in Milan, Italy, between 2009 and 2015...
January 19, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28317399/recent-advances-in-pediatric-celiac-disease
#3
Grace J Lee, John Y Kao
The incidence of celiac disease (CD) has increased over the last half-century, resulting in rising interest in identifying risk factors for CD. The necessity of duodenal biopsies in the diagnosis of CD has recently been challenged. Areas covered: This review covers the recent literature regarding the role of infant feeding practices, including breastfeeding and timing of gluten introduction, and the microbiota in the development of CD. Additionally, the application of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for a non-biopsy approach to the diagnosis of CD is reviewed...
March 20, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28300220/effects-of-gliadin-consumption-on-the-intestinal-microbiota-and-metabolic-homeostasis-in-mice-fed-a-high-fat-diet
#4
Li Zhang, Daniel Andersen, Henrik Munch Roager, Martin Iain Bahl, Camilla Hartmann Friis Hansen, Niels Banhos Danneskiold-Samsøe, Karsten Kristiansen, Ilinca Daria Radulescu, Christian Sina, Henrik Lauritz Frandsen, Axel Kornerup Hansen, Susanne Brix, Lars I Hellgren, Tine Rask Licht
Dietary gluten causes severe disorders like celiac disease in gluten-intolerant humans. However, currently understanding of its impact in tolerant individuals is limited. Our objective was to test whether gliadin, one of the detrimental parts of gluten, would impact the metabolic effects of an obesogenic diet. Mice were fed either a defined high-fat diet (HFD) containing 4% gliadin (n = 20), or a gliadin-free, isocaloric HFD (n = 20) for 23 weeks. Combined analysis of several parameters including insulin resistance, histology of liver and adipose tissue, intestinal microbiota in three gut compartments, gut barrier function, gene expression, urinary metabolites and immune profiles in intestinal, lymphoid, liver and adipose tissues was performed...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28288222/-the-benefits-of-breastfeeding-and-associated-risks-of-replacement-with-baby-formulas
#5
Paulina Brahm, Verónica Valdés
Breastfeeding is the nourishment designed by nature for the newborn and the infant; however its prevalence is nowadays not optimal. The aim of this article is to review the current evidence of the benefits of breastfeeding for children and society, and to elaborate the risks associated with the replacement of lactation with baby formulas. Breastfeeding is a protective factor for several infectious, atopic, and cardiovascular diseases as well as for leukaemia, necrotising enterocolitis, celiac disease, and inflammatory bowel disease...
February 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28204873/dysbiosis-a-risk-factor-for-celiac-disease
#6
REVIEW
Anamaria Girbovan, Genel Sur, Gabriel Samasca, Iulia Lupan
Celiac disease remains one of the most challenging pathologies of the small intestine. It involves multiple pathogenic pathways and there are no disease-changing pharmacological agents available against it yet. The term microbiota refers to the community of microorganisms that inhabit a particular region of the body. Normal gut microbiota has a vital role in maintaining the intestinal homeostasis and promoting health. Celiac disease is associated with microbiota alteration, especially with an increase in the number of Gram-negative bacteria and a decrease in the number of Gram-positive bacteria...
February 15, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/28140462/physiopathology-and-management-of-gluten-induced-celiac-disease
#7
REVIEW
Jitendra Kumar, Manoj Kumar, Rajesh Pandey, Nar Singh Chauhan
Proline- and glutamine-rich gluten proteins are one of the major constituents of cereal dietary proteins, which are largely resistant to complete cleavage by the human gastrointestinal (GI) digestive enzymes. Partial digestion of gluten generates approximately 35 amino acids (aa) immunomodulatory peptides which activate T-cell-mediated immune system, followed by immunological inflammation of mucosa leading to the onset of celiac disease (CD). CD is an autoimmune disease associated with HLA-DQ2/DQ8 polymorphism and dysbiosis of gut microbiota...
January 31, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/27933057/glutamine-induced-secretion-of-intestinal-secretory-immunoglobulin-a-a-mechanistic-perspective
#8
REVIEW
Wenkai Ren, Kai Wang, Jie Yin, Shuai Chen, Gang Liu, Bie Tan, Guoyao Wu, Fuller W Bazer, Yuanyi Peng, Yulong Yin
Secretory immunoglobulin A (SIgA) is one important line of defense in the intestinal mucosal surface to protect the intestinal epithelium from enteric toxins and pathogenic microorganisms. Multiple factors, such as intestinal microbiota, intestinal cytokines, and nutrients are highly involved in production of SIgA in the intestine. Recently, glutamine has been shown to affect intestinal SIgA production; however, the underlying mechanism by which glutamine stimulates secretion of intestinal SIgA is unknown. Here, we review current knowledge regarding glutamine in intestinal immunity and show that glutamine-enhanced secretion of SIgA in the intestine may involve intestinal microbiota, intestinal antigen sampling and presentation, induction pathways for SIgA production by plasma cells (both T-dependent and T-independent pathway), and even transport of SIgA...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27833600/mucosal-prevalence-and-interactions-with-the-epithelium-indicate-commensalism-of-sutterella-spp
#9
Kaisa Hiippala, Veera Kainulainen, Marko Kalliomäki, Perttu Arkkila, Reetta Satokari
Sutterella species have been frequently associated with human diseases, such as autism, Down syndrome, and inflammatory bowel disease (IBD), but the impact of these bacteria on health still remains unclear. Especially the interactions of Sutterella spp. with the host are largely unknown, despite of the species being highly prevalent. In this study, we addressed the interaction of three known species of Sutterella with the intestinal epithelium and examined their adhesion properties, the effect on intestinal barrier function and the pro-inflammatory capacity in vitro...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27741161/gut-microbiota-and-risk-of-developing-celiac-disease
#10
Maria C Cenit, Pilar Codoñer-Franch, Yolanda Sanz
Gut microbiota shapes the development of the mucosal immune system and may provide protection against immune-mediated diseases. Celiac disease (CD) is a chronic inflammatory condition triggered by dietary gluten proteins, recently associated with gut microbiota alterations in cross-sectional studies comparing patients and controls. Whether or not these differences are causally related to the disease has yet to be elucidated, but evaluation of specific bacteria isolated from CD patients in experimental models suggests that they can promote an adverse response to dietary gluten, whereas other commensal bacteria can be protective...
November 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27741160/the-interaction-between-celiac-disease-and-intestinal-microbiota
#11
Giuseppe Losurdo, Mariabeatrice Principi, Andrea Iannone, Enzo Ierardi, Alfredo Di Leo
Celiac disease (CD) is the most common autoimmune enteropathy, triggered by a deregulated immune response to gliadin. It has been hypothesized that human intestinal microbiota may interfere with the pathogenesis of the disease and in the clinical course of CD. In the present review, we analyzed the microbiota alterations observed in the course of CD, how they may influence the pathogenesis of CD, and the possible applications for a microbiota modulation in CD. In detail, most of the current literature underlined that the dysbiosis in CD is hallmarked by an increase in gram-negative and Bacteroidetes species, and by a decrease in Bifidobacteria and Lactobacilli...
November 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27689204/serendipity-in-refractory-celiac-disease-full-recovery-of-duodenal-villi-and-clinical-symptoms-after-fecal-microbiota-transfer
#12
Yvette H van Beurden, Tom van Gils, Nienke A van Gils, Zain Kassam, Chris J J Mulder, Nieves Aparicio-Pagés
Treatment of refractory celiac disease type II (RCD II) and preventing the development of an enteropathy associated T-cell lymphoma in these patients is still difficult. In this case report, we describe a patient with RCD II who received fecal microbiota transfer as treatment for a recurrent Clostridium difficile infection, and remarkably showed a full recovery of duodenal villi and disappearance of celiac symptoms. This case suggests that altering the gut microbiota may hold promise in improving the clinical and histological consequences of celiac disease and/or RCD II...
September 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/27688656/gastrointestinal-disorders-associated-with-migraine-a-comprehensive-review
#13
REVIEW
Carlos R Cámara-Lemarroy, Rene Rodriguez-Gutierrez, Roberto Monreal-Robles, Alejandro Marfil-Rivera
Migraine is a recurrent and commonly disabling primary headache disorder that affects over 17% of women and 5%-8% of men. Migraine susceptibility is multifactorial with genetic, hormonal and environmental factors all playing an important role. The physiopathology of migraine is complex and still not fully understood. Many different neuropeptides, neurotransmitters and brain pathways have been implicated. In connection with the myriad mechanisms and pathways implicated in migraine, a variety of multisystemic comorbidities (e...
September 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27648810/interleukin-15-promotes-intestinal-dysbiosis-with-butyrate-deficiency-associated-with-increased-susceptibility-to-colitis
#14
Marlies Meisel, Toufic Mayassi, Hannah Fehlner-Peach, Jason C Koval, Sarah L O'Brien, Reinhard Hinterleitner, Kathryn Lesko, Sangman Kim, Romain Bouziat, Li Chen, Christopher R Weber, Sarkis K Mazmanian, Bana Jabri, Dionysios A Antonopoulos
Dysbiosis resulting in gut-microbiome alterations with reduced butyrate production are thought to disrupt intestinal immune homeostasis and promote complex immune disorders. However, whether and how dysbiosis develops before the onset of overt pathology remains poorly defined. Interleukin-15 (IL-15) is upregulated in distressed tissue and its overexpression is thought to predispose susceptible individuals to and have a role in the pathogenesis of celiac disease and inflammatory bowel disease (IBD). Although the immunological roles of IL-15 have been largely studied, its potential impact on the microbiota remains unexplored...
January 2017: ISME Journal
https://www.readbyqxmd.com/read/27647538/mood-disorders-and-non-celiac-gluten-sensitivity
#15
Giovanni Casella, Roberta Pozzi, Marta Cicognetti, Francesco Bachetti, Gabriele Torti, Moris Cadei, Vincenzo Villanacci, Vittorio Baldini, Gabrio Bassotti
The association between gluten related disorders and psychiatric diseases has been firmly demonstrated. Non celiac gluten sensitivity (NCGS) is a syndrome diagnosed in patients responsive to gluten free diet after ruling out celiac disease and wheat allergy. The pathogenesis of neuro-psychiatric disorders in NCGS is unclear. An association between gluten and schizophrenia was described for the first time in 1950 by Bender et al. In the 50', Dicke noted that gluten free diet improved mood in celiac patients...
September 20, 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/27525027/probiotics-and-the-microbiome-in-celiac-disease-a-randomised-controlled-trial
#16
Joanna Harnett, Stephen P Myers, Margaret Rolfe
Background. There is limited research investigating the composition of the gastrointestinal microbiota in individuals with celiac disease (CoeD) reporting only partial symptom improvement despite adherence to a strict gluten-free diet (GFD). The aim of this research was to determine if the gastrointestinal microbiota could be altered by probiotic bacteria and provide a potential new therapy for this subgroup. Methods. A multicentre RCT was conducted between January and August 2011 in Australia. Participants included 45 people with CoeD reporting only partial symptom improvement despite adherence to a strict GFD for a minimum of 12 months...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27452636/salivary-and-fecal-microbiota-and-metabolome-of-celiac-children-under-gluten-free-diet
#17
Maria De Angelis, Lucia Vannini, Raffaella Di Cagno, Noemi Cavallo, Fabio Minervini, Ruggiero Francavilla, Danilo Ercolini, Marco Gobbetti
Celiac disease (CD) is an inflammatory autoimmune disorder resulting from the combination of genetic predisposition and gluten ingestion. A life-long gluten free diet (GFD) is the only therapeutic approach. Dysbiosis, which can precede the CD pathogenesis and/or persist when subjects are on GFD, is reviewed and discussed. Salivary microbiota and metabolome differed between healthy and celiac children treated under GFD (T-CD) for at least two years. The type of GFD (African- vs Italian-style) modified the microbiota and metabolome of Saharawi T-CD children...
December 19, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27373514/duodenal-bacteria-from-patients-with-celiac-disease-and%C3%A2-healthy-subjects-distinctly-affect-gluten-breakdown%C3%A2-and%C3%A2-immunogenicity
#18
Alberto Caminero, Heather J Galipeau, Justin L McCarville, Chad W Johnston, Steve P Bernier, Amy K Russell, Jennifer Jury, Alexandra R Herran, Javier Casqueiro, Jason A Tye-Din, Michael G Surette, Nathan A Magarvey, Detlef Schuppan, Elena F Verdu
BACKGROUND & AIMS: Partially degraded gluten peptides from cereals trigger celiac disease (CD), an autoimmune enteropathy occurring in genetically susceptible persons. Susceptibility genes are necessary but not sufficient to induce CD, and additional environmental factors related to unfavorable alterations in the microbiota have been proposed. We investigated gluten metabolism by opportunistic pathogens and commensal duodenal bacteria and characterized the capacity of the produced peptides to activate gluten-specific T-cells from CD patients...
October 2016: Gastroenterology
https://www.readbyqxmd.com/read/27216895/immunogenetic-pathogenesis-of-celiac-disease-and-non-celiac-gluten-sensitivity
#19
REVIEW
Celia Escudero-Hernández, Amado Salvador Peña, David Bernardo
Celiac disease is the most common oral intolerance in Western countries. It results from an immune response towards gluten proteins from certain cereals in genetically predisposed individuals (HLA-DQ2 and/or HLA-DQ8). Its pathogenesis involves the adaptive (HLA molecules, transglutaminase 2, dendritic cells, and CD4(+) T-cells) and the innate immunity with an IL-15-mediated response elicited in the intraepithelial compartment. At present, the only treatment is a permanent strict gluten-free diet (GFD). Multidisciplinary studies have provided a deeper insight of the genetic and immunological factors and their interaction with the microbiota in the pathogenesis of the disease...
July 2016: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/27175113/pathogenic-role-of-the-gut-microbiota-in-gastrointestinal-diseases
#20
REVIEW
Hiroko Nagao-Kitamoto, Sho Kitamoto, Peter Kuffa, Nobuhiko Kamada
The gastrointestinal (GI) tract is colonized by a dense community of commensal microorganisms referred to as the gut microbiota. The gut microbiota and the host have co-evolved, and they engage in a myriad of immunogenic and metabolic interactions. The gut microbiota contributes to the maintenance of host health. However, when healthy microbial structure is perturbed, a condition termed dysbiosis, the altered gut microbiota can trigger the development of various GI diseases including inflammatory bowel disease, colon cancer, celiac disease, and irritable bowel syndrome...
April 2016: Intestinal Research
keyword
keyword
100447
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"