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https://www.readbyqxmd.com/read/28081267/single-nucleotide-variants-of-candidate-genes-in-aggrecan-metabolic-pathway-are-associated-with-lumbar-disc-degeneration-and-modic-changes
#1
Romain Shanil Perera, Poruwalage Harsha Dissanayake, Upul Senarath, Lalith Sirimevan Wijayaratne, Aranjan Lional Karunanayake, Vajira Harshadeva Weerabaddana Dissanayake
INTRODUCTION: Lumbar disc degeneration (LDD) is genetically determined and severity of LDD is associated with Modic changes. Aggrecan is a major proteoglycan in the intervertebral disc and end plate. Progressive reduction of aggrecan is a main feature of LDD and Modic changes. OBJECTIVES: The study investigated the associations of single nucleotide variants (SNVs) of candidate genes in the aggrecan metabolic pathway with the severity of LDD and Modic changes. In-silico functional analysis of significant SNVs was also assessed...
2017: PloS One
https://www.readbyqxmd.com/read/28043884/risk-factors-for-the-recurrent-herniation-after-percutaneous-endoscopic-lumbar-discectomy
#2
Yuan Yao, Huan Liu, Huiyu Zhang, Honggang Wang, Chao Zhang, Zhengfeng Zhang, Junlong Wu, Yu Tang, Yue Zhou
BACKGROUND: Percutaneous endoscopic lumbar discectomy (PELD) has been widely used for treating lumbar disc herniation (LDH). Recurrence after PELD has been reported, but few studies have focused on the risk factors responsible for PELD recurrence. METHODS: From March 2005 to March 2016, 116 patients suffering from recurrent herniation after successful PELD were enrolled in this retrospective study. Kaplan-Meier methods and Cox regression analysis were employed to identify the significant risk factors predicting PELD recurrence...
December 30, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28031964/10-years-of-research-from-ignoring-modic-changes-to-considerations-regarding-treatment-and-prevention-of-low-grade-disc-infections
#3
EDITORIAL
Claus Manniche, Alan Jordan
No abstract text is available yet for this article.
June 2016: Future Science OA
https://www.readbyqxmd.com/read/27997510/a-whole-exome-study-identifies-novel-candidate-genes-for-vertebral-bone-marrow-signal-changes-modic-changes
#4
Minna Kraatari, Sini Skarp, Niinimäki Jaakko, Jaro Karppinen, Minna Männikkö
STUDY DESIGN: Family-based study OBJECTIVE.: To identify rare genetic factors predisposing to Modic changes (MC). SUMMARY OF BACKGROUND DATA: Lumbar disc degeneration (LDD) is one of the contributing factors behind low back pain (LBP). Lumbar MC visualized as bone marrow signal intensity changes on magnetic resonance imaging (MRI) represent a specific phenotype of LDD, which has stronger association with LBP than LDD without MC. METHODS: The study set consisted of two Finnish families: Family I included seven affected and four unaffected individuals and Family II eight affected and seven unaffected individuals...
December 16, 2016: Spine
https://www.readbyqxmd.com/read/27917347/identification-of-lumbar-disc-disease-hallmarks-a-large-cross-sectional-study
#5
Jun Zhang, Fei Zhao, Feng-Liang Wang, Yong-Feng Yang, Chen Zhang, Yue Cao, You-Lin Wang, Xiao-Juan Shi, Yi Wan, Min Zhang, Meng-Qiao Liu, Chun-Guang Zuo, Hai-Qiang Wang
BACKGROUND: Lumbar disc disease has a disabling impact on global people with heavy burden on society, mainly consisting of lumbar disc degeneration (LDD) and lumbar disc herniation (LDH). The recently released lumbar disc nomenclature version 2.0 deepens our understandings on the diseases. Consequently, there is an urgent need to clarify the occurrence and distribution features of LDD and LDH in a large-scale sample in terms of the novel version. QUESTION/PURPOSES: We asked: (1) Is there a difference in the occurrence and distribution hallmarks of LDD and LDH in a population-based large-scale sample? (2) Does the novel nomenclature version bring novel vision on lumbar disc disease? METHODS: Five thousand two hundred eighty-eight consecutive cases (26,440 lumbar discs) undergoing lumbar spine MRI were retrospectively included from Jan 2008 to Dec 2010 in a territory university hospital...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27908306/comparing-diffusion-weighted-imaging-with-clinical-and-blood-parameters-and-with-short-tau-inversion-recovery-sequence-in-detecting-spinal-and-sacroiliac-joint-inflammation-in-axial-spondyloarthritis
#6
Ho Yin Chung, Xiaopei Xu, Vince Wing Hang Lau, Grace Ho, Ka Lai Lee, Philip Hei Li, Helen Hoi Lun Tsang, Suet Kei Kwok, Chak Sing Lau, Chun Sing Wong
OBJECTIVES: To investigate the usefulness of diffusion weighted imaging (DWI) by comparing with clinical features, blood parameters and traditional short tau inversion recovery (STIR) sequence in detecting spinal and sacroiliac (SI) joint inflammation in axial spondyloarthritis (axSpA) patients. METHODS: One hundred and ten axSpA patients were recruited. Clinical, radiological and blood parameters were recorded. DWI and STIR MRI were performed simultaneously and results were scored according to the Spondyloarthritis Research Consortium of Canada (SPARCC) for comparison...
November 13, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27885471/modic-changes-in-the-adjacent-vertebrae-due-to-disc-material-infection-with-propionibacterium-acnes-in-patients-with-lumbar-disc-herniation
#7
Javad Aghazadeh, Firooz Salehpour, Ehsan Ziaeii, Naghme Javanshir, Afshin Samadi, Javid Sadeghi, Farhad Mirzaei, Seyed Ahmad Naseri Alavi
INTRODUCTION: Modic changes (MCs) in vertebral bones are induced by two mechanisms of mechanical factors and infection. As Propionibacterium acnes (P. acnes) have been reported to be associated with LBP. The aim of this study is to evaluate the MCs in patients with disc herniation and positive for P. acnes. METHODS AND MATERIAL: A total of 120 patients with disc herniation surgery were enrolled into the study. The samples were excised during discectomy and then cultured in both anaerobic and aerobic incubations...
November 24, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27873048/the-usefulness-of-radiological-grading-scales-to-predict-pain-intensity-functional-impairment-and-health-related-quality-of-life-after-surgery-for-lumbar-degenerative-disc-disease
#8
Oliver P Gautschi, Martin N Stienen, Holger Joswig, Nicolas R Smoll, Karl Schaller, Marco V Corniola
PURPOSE: The goal of this study is to determine the relationship of radiological grading scales of lumbar degenerative disc disease (DDD) with postoperative pain intensity, functional impairment, and health-related quality of life (HRQoL). METHODS: Response to surgical treatment at 6 weeks (W6) on the visual analogue scale (VAS) for back and leg pain, Oswestry-Disability (ODI) and Roland-Morris Disability Index (RMDI), Timed Up and Go (TUG) test, EuroQol (EQ) 5D, and Short-Form Health-Survey (SF-12) physical component summary (PCS) was compared between patients with different Modic (MOD) and Pfirrmann (PFI) grades...
November 21, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27826211/nucleoplasty-for-treating-lumbar-disk-degenerative-low-back-pain-an-outcome-prediction-analysis
#9
Po-Chou Liliang, Kang Lu, Cheng-Loong Liang, Ya-Wen Chen, Yu-Duan Tsai, Yuan-Kun Tu
PURPOSE: Nucleoplasty is a minimally invasive technique that is considered efficacious in alleviating lumbar disk degenerative low back pain (LBP). The efficacy of nucleoplasty and identified variables that can predict pain relief for nucleoplasty was reported. PATIENTS AND METHODS: Between December 2013 and November 2015, 47 nucleoplasty procedures on 47 lumbar disks in 31 consecutive patients were performed. The outcome was evaluated using a visual analog scale (VAS) score...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27765024/lumbar-disc-degeneration-is-associated-with-modic-change-and-high-paraspinal-fat-content-a-3-0t-magnetic-resonance-imaging-study
#10
Andrew J Teichtahl, Donna M Urquhart, Yuanyuan Wang, Anita E Wluka, Richard O'Sullivan, Graeme Jones, Flavia M Cicuttini
BACKGROUND: Degenerative disc disease of the lumbar spine is common, with severe disease increasing the risk for chronic low back pain. This cross-sectional study examined whether disc degeneration is representative of a 'whole-organ' pathology, by examining its association with bone (vertebral endplate) and soft tissue (paraspinal muscle fat) abnormalities. METHODS: Seventy-two community-based individuals unselected for low back pain, had Magnetic Resonance Imaging (MRI)...
October 21, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27755211/a-leadership-education-and-development-program-for-clinical-nurses
#11
Joyce J Fitzpatrick, Mary Beth Modic, Jennifer Van Dyk, K Kelly Hancock
OBJECTIVE: The Leadership Education and Development (LEAD) Program was designed to transform care at the bedside by empowering clinical nurses as leaders. BACKGROUND: The heart of LEAD was enhancing communication skills of clinical nurses with clinical colleagues and, most importantly, patients and families. Key concepts of leadership/management were included: personal awareness, personal leadership skills/abilities, leading change, leading others individually and in teams, enhancing the patient/provider experience, and the leadership role in outcomes management...
November 2016: Journal of Nursing Administration
https://www.readbyqxmd.com/read/27755205/lumbar-facet-resurfacing-first-experience-with-the-fenix-implant
#12
Erik V de Kelft
STUDY DESIGN: This is a feasibility study to confirm the design, patient population, and the surgical technique for FENIX implants. OBJECTIVE: This study evaluated the safety and the clinical and radiologic performance of bilaterally implanted FENIX facet resurfacing device. INTRODUCTION: Facet joint osteoarthritis is responsible for up to 30% of chronic low back pain. Arthroplasty is a surgical treatment option that aims to relieve pain while maintaining or restoring motion...
November 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27742376/occurrence-of-discal-and-non-discal-changes-after-sequestrectomy-alone-versus-sequestrectomy-and-implantation-of-an-anulus-closure-device
#13
Martin Barth, Johann Fontana, Claudius Thomé, Gerrit J Bouma, Kirsten Schmieder
Sequestrectomy alone represents a procedure for the treatment of lumbar disc herniation. For selected cases, an anulus closure device (ACD) can be implanted which may result in lower reoperation rates. However, comparative magnetic resonance imaging (MRI) changes and their clinical relevance of both procedures are unclear and have not been reported so far. Clinical and MRI data of patients after limited discectomy with ACD implantation (group ACD; N=45) and patients after sequestrectomy alone (group S; N=40) with primary lumbar disc herniation were compared retrospectively...
October 11, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27713567/an-animal-model-of-modic-changes-by-embedding-autogenous-nucleus-pulposus-inside-subchondral-bone-of-lumbar-vertebrae
#14
Chao Han, Tao Wang, Hong-Qiang Jiang, Jian-Xiong Ma, Peng Tian, Jia-Cheng Zang, Xin-Long Ma
The establishment of Modic changes (MCs) in animal model was vital for research of MCs. Fifty-four rabbits were divided into a sham group, a muscle embedment group (ME group) and nucleus pulposus (NP) embedment group (NPE group). In the NPE group, the discs were exposed by the lumbar anterolateral surgical approach. A needle was used to puncture the L5 vertebral body close to the endplate. NP was extracted by a syringe from L1/2 intervertebral discs and then injected into the drilled hole of subchondral bone...
October 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27709276/the-intervertebral-disc-the-endplates-and-the-vertebral-bone-marrow-as-a-unit-in-the-process-of-degeneration
#15
Nadja A Farshad-Amacker, Alexander Hughes, Richard J Herzog, Burkhardt Seifert, Mazda Farshad
OBJECTIVES: The association of disc degeneration (DD) and vertebral endplate degeneration (EPD) is still not well understood. This study aimed to find segmental predictive risk factors for DD and EPD and to illuminate associations of the disc, endplate and bone marrow changes in the process of degeneration. METHODS: After institutional review board approval, 450 lumbar levels, followed up with MRI for at least 4 years, were retrospectively graded for DD according to Pfirrmann (PFG), for EPD according to the endplate score (EPS) and according to the presence, extension and type of Modic changes (MC)...
October 5, 2016: European Radiology
https://www.readbyqxmd.com/read/27690264/measurement-of-fat-content-in-vertebral-marrow-using-a-modified-dixon-sequence-to-differentiate-benign-from-malignant-processes
#16
Hye Jin Yoo, Sung Hwan Hong, Dong Hyun Kim, Ja-Young Choi, Hee Dong Chae, Bo Mi Jeong, Joong Mo Ahn, Heung Sik Kang
PURPOSE: To determine whether fat-signal-fraction (FF) map using a modified Dixon sequence could help differentiate benign from malignant bone lesions. MATERIALS AND METHODS: Spine magnetic resonance images (MRIs) of 120 consecutive patients were studied by using a 3T MRI with standard T1 -weighted image (T1 WI) and modified-Dixon sequence for FF measurement. There were three groups: a control group (n = 51) with normal vertebrae; a benign group (n = 40) with focal red marrow deposition, Schmorl's nodes, benign compression fracture, or Modic type 1 endplate degeneration; a malignant group (n = 29) with spinal malignancies...
September 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27687057/relationship-of-modic-changes-disk-herniation-morphology-and-axial-location-to-outcomes-in-symptomatic-cervical-disk-herniation-patients-treated-with-high-velocity-low-amplitude-spinal-manipulation-a-prospective-study
#17
Michel Kressig, Cynthia K Peterson, Kyle McChurch, Christof Schmid, Serafin Leemann, Bernard Anklin, B Kim Humphreys
OBJECTIVE: The purpose of this study was to evaluate whether cervical disk herniation (CDH) location, morphology, or Modic changes (MCs) are related to treatment outcomes. METHODS: Magnetic resonance imaging (MRI) and outcome data from 44 patients with CDH treated with spinal manipulative therapy were evaluated. MRI scans were assessed for CDH axial location, morphology, and MCs. Pain (0-10 for neck and arm) and Neck Disability Index (NDI) data were collected at baseline; 2 weeks; 1, 3, and 6 months; and 1 year...
October 2016: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/27649071/classification-of-high-intensity-zones-of-the-lumbar-spine-and-their-association-with-other-spinal-mri-phenotypes-the-wakayama-spine-study
#18
Masatoshi Teraguchi, Dino Samartzis, Hiroshi Hashizume, Hiroshi Yamada, Shigeyuki Muraki, Hiroyuki Oka, Jason Pui Yin Cheung, Ryohei Kagotani, Hiroki Iwahashi, Sakae Tanaka, Hiroshi Kawaguchi, Kozo Nakamura, Toru Akune, Kenneth Man-Chee Cheung, Noriko Yoshimura, Munehito Yoshida
INTRODUCTION: High intensity zones (HIZ) of the lumbar spine are a phenotype of the intervertebral disc noted on MRI whose clinical relevance has been debated. Traditionally, T2-weighted (T2W) magnetic resonance imaging (MRI) has been utilized to identify HIZ of lumbar discs. However, controversy exists with regards to HIZ morphology, topography, and association with other MRI spinal phenotypes. Moreover, classification of HIZ has not been thoroughly defined in the past and the use of additional imaging parameters (e...
2016: PloS One
https://www.readbyqxmd.com/read/27648906/human-flourishing-precepting-with-purpose
#19
Mary Beth Modic
No abstract text is available yet for this article.
September 2016: Journal for Nurses in Professional Development
https://www.readbyqxmd.com/read/27592808/ablation-of-the-basivertebral-nerve-for-treatment-of-back-pain-a-clinical-study
#20
Stephan Becker, Alexander Hadjipavlou, Michael H Heggeness
BACKGROUND CONTENT: Lumbar axial back pain arising from degenerative disc disease continues to be a challenging clinical problem whether treated with nonsurgical management, local injection, or motion segment stabilization and fusion. PURPOSE: The purpose of this study was to determine the efficacy of intraosseous basivertebral nerve (BVN) ablation for the treatment of chronic lumbar back pain in a clinical setting. STUDY DESIGN: Patients meeting predefined inclusion or exclusion criteria were enrolled in a study using radiofrequency energy to ablate the BVN within the vertebral bodies adjacent to the diagnosed level...
September 1, 2016: Spine Journal: Official Journal of the North American Spine Society
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