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David Modic, Ross Anderson, Jussi Palomäki
Psychological and other persuasive mechanisms across diverse contexts are well researched, with many studies of the effectiveness of specific persuasive techniques on distinct types of human behaviour. In the present paper, our specific interest lies in the development of a generalized modular psychometric tool to measure individuals' susceptibility to persuasion. The scale is constructed using items from previously developed and validated particulate scales established in the domains of social psychology and behavioural economics...
2018: PloS One
Mads Ryø Jochumsen, Michael Alle Madsen, Lise Gammelgaard, Kirsten Bouchelouche
A 75-year-old man with recently diagnosed high-risk prostate cancer was referred for primary staging with Ga-prostate-specific membrane antigen (PSMA) PET/CT. The scan revealed intense Ga-PSMA uptake in a lumbar osteophyte on the right side of level L2/L3, whereas several other spinal osteophytes showed no Ga-PSMA uptake. MRI findings in the L3 vertebra was consistent with a benign Modic type 1 lesion, but MRI showed no signs of malignancy in the osteophyte with high Ga-PMSA uptake. This case presents an osteophyte as an addition to the list of potential benign pitfalls to be aware of when interpreting Ga-PSMA PET/CT...
March 13, 2018: Clinical Nuclear Medicine
Margareta Nordin, Kristi Randhawa, Paola Torres, Hainan Yu, Scott Haldeman, O'Dane Brady, Pierre Côté, Carlos Torres, Michael Modic, Rajani Mullerpatan, Christine Cedraschi, Roger Chou, Emre Acaroğlu, Eric L Hurwitz, Nadège Lemeunier, Jean Dudler, Anne Taylor-Vaisey, Erkin Sönmez
PURPOSE: The purpose of this systematic literature review was to develop recommendations for the assessment of spine-related complaints in medically underserved areas with limited resources. METHODS: We conducted a systematic review and best evidence synthesis of guidelines on the assessment of spine-related complaints. Independent reviewers critically appraised eligible guidelines using the Appraisal of Guidelines for Research and Evaluation-II criteria. Low risk of bias clinical practice guidelines was used to develop recommendations...
February 28, 2018: European Spine Journal
Jiangbo Bai, Kunlun Yu, Yaning Sun, Lingde Kong, Yong Shen
Background: The aim of this study was to assess the prevalence of cervical Modic change (MC) in patients with cervical spondylosis and to develop a better understanding of the possible risk factors for the prevalence of MC. Methods: Between January 2014 and April 2017, patients with cervical spondylosis were included in our study. All patients underwent magnetic resonance imaging (MRI) to evaluate the presence of MC. The MC was classified into three types according to the Modic classification...
2018: Journal of Pain Research
Rikke K Jensen, Peter Kent, Tue S Jensen, Per Kjaer
BACKGROUND: Research into the clinical importance of spinal MRI findings in patients with low back pain (LBP) has primarily focused on single imaging findings, such as Modic changes or disc degeneration, and found only weak associations with the presence of pain. However, numerous MRI findings almost always co-exist in the lumbar spine and are often present at more than one lumbar level. It is possible that multiple MRI findings are more strongly associated with LBP than single MRI findings...
February 20, 2018: BMC Musculoskeletal Disorders
R Figa, C Morera-Dominguez
OBJECTIVE: To evaluate the predictive value of Modic typeII changes on nuclear magnetic resonance (NMR) prior to intervention by discectomy for lumbar disc herniation in patients with radicular symptoms. MATERIAL AND METHOD: Retrospective descriptive study of 190 patients (58.2% men and 41.8% women) with a mean age of 43.5 years, treated between December 2005 and January 2013. They were divided into group 1, single disc herniation (n=85), and group 2, with disc herniation and changes Modic typeII (n=80)...
February 6, 2018: Revista Española de Cirugía Ortopédica y Traumatología
Yukihiro Matsuyama, Kazuhiro Chiba, Hisashi Iwata, Takayuki Seo, Yoshiaki Toyama
OBJECTIVE Chemonucleolysis with condoliase has the potential to be a new, less invasive therapeutic option for patients with lumbar disc herniation (LDH). The aim of the present study was to determine the most suitable therapeutic dose of condoliase. METHODS Patients between 20 and 70 years of age with unilateral leg pain, positive findings on the straight leg raise test, and LDH were recruited. All eligible patients were randomly assigned to receive condoliase (1.25, 2.5, or 5 U) or placebo. The primary end point was a change in the worst leg pain from preadministration (baseline) to week 13...
February 9, 2018: Journal of Neurosurgery. Spine
Jeffrey S Fischgrund, A Rhyne, J Franke, R Sasso, S Kitchel, H Bae, C Yeung, E Truumees, M Schaufele, P Yuan, P Vajkoczy, M DePalma, D G Anderson, L Thibodeau, B Meyer
PURPOSE: To evaluate the safety and efficacy of radiofrequency (RF) ablation of the basivertebral nerve (BVN) for the treatment of chronic low back pain (CLBP) in a Food and Drug Administration approved Investigational Device Exemption trial. The BVN has been shown to innervate endplate nociceptors which are thought to be a source of CLBP. METHODS: A total of 225 patients diagnosed with CLBP were randomized to either a sham (78 patients) or treatment (147 patients) intervention...
February 8, 2018: European Spine Journal
Koji Tamai, Jessica Chen, Michael Stone, Anush Arakelyan, Permsak Paholpak, Hiroaki Nakamura, Zorica Buser, Jeffrey C Wang
PURPOSE: The cross-sectional area and fat infiltration are accepted as standard parameters for quantitative and qualitative evaluation of muscle degeneration. However, they are time-consuming, which prevents them from being used in a clinical setting. The aim of this study was to analyze the relationship between lumbar muscle degeneration and spinal degenerative disorders, using lumbar indentation value (LIV) as quantitative and Goutallier classification as qualitative measures. METHODS: This is a retrospective analysis of kinematic magnetic resonance images (kMRI)...
February 2, 2018: European Spine Journal
Hanna Hebelka, Andreia Miron, Izabela Kasperska, Helena Brisby, Kerstin Lagerstrand
BACKGROUND: The function of the endplate (EP) is the most important factor influencing nutritional supply to the avascular intervertebral disc (IVD). It is desired to have a non-invasive method to assess functional EP characteristics in vivo. Assessment of functional EP characteristics is important in order to understand its relation to IVD degeneration, which in turn might deepen the understanding of the pathophysiology behind low back pain (LBP). It was hypothesized that, by comparing quantitative MRI of EPs performed with conventional supine MRI (unloaded MRI) with axial loading during MRI (alMRI), dynamical properties of the EP can be displayed...
January 30, 2018: Journal of Orthopaedic Surgery and Research
Koji Tamai, Joshua Romanu, Phillip Grisdela, Permsak Paholpak, Pengfei Zheng, Hiroaki Nakamura, Zorica Buser, Jeffrey C Wang
BACKGROUND CONTEXT: Cervical sagittal vertical axis (cSVA) of ≥40mm is recognized as the key factor of poor health-related quality of life, poor surgical outcomes, and correction loss after surgery for cervical deformity. However, little is known about the radiological characteristics of patients with cSVA≥40mm. PURPOSE: The purpose of this study was to identify the radiological characteristics of patients with cervical imbalance. DESIGN: Retrospective analysis of weight-bearing cervical magnetic resonance (MR) images PATIENT SAMPLE: Consecutive 1,500 MR images of symptomatic patients in weight-bearing position OUTCOME MEASURES: cSVA, cervical alignment, cervical balance parameters (T1 slope, Co-C2 angle, C2-C7 angle, C7-T1 angle, neck tilt and thoracic inlet angle), disc degeneration (Pfirmann and Suzuki classification), endplate degeneration (Modic change), Spondylolisthesis (antero- and retrolisthesis), antero-posterior (AP) diameter of dural sac, cross-sectional area (CSA) and fat infiltration ratio of the transversospinalis muscles at C4 and C7 levels METHODS: Patients were divided into two groups: cervical sagittal vertical axis (cSVA) ≥40mm and <40mm...
January 17, 2018: Spine Journal: Official Journal of the North American Spine Society
Guoqi Cai, Laura L Laslett, Dawn Aitken, Andrew Halliday, Feng Pan, Petr Otahal, Deborah Speden, Tania M Winzenberg, Graeme Jones
The aim of this study was to evaluate the effect of zoledronic acid (ZA) and denosumab on low back pain (LBP) and Modic change (MC) over 6 months. Adults aged ≥40 years with significant LBP for at least 6 months duration and MC (type 1, 2, or mixed) were randomized to receive ZA (5 mg/100 mL), denosumab (60 mg), or placebo. LBP was measured monthly by visual analogue scale (VAS) and the LBP Rating Scale (RS). MC was measured from MRIs of T12 -S1 vertebrae at screening and 6 months. A total of 103 participants with moderate/severe LBP (mean VAS = 57 mm; mean RS = 18) and median total MC area 538 mm2 were enrolled...
January 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Daniel Lubelski, Vincent Alentado, Seth Williams, Colin O'Rourke, Nancy Obuchowski, Jeffrey C Wang, Michael Steinmetz, Alfred Melillo, Edward Benzel, Michael Modic, Robert Quencer, Thomas Mroz
BACKGROUND: There are a multitude of treatments for low grade lumbar spondylolisthesis. There are no clear guidelines for the optimal approach. OBJECTIVE: To identify the surgical treatment patterns for spondylolisthesis, among United States spine surgeons METHODS: 445 US spine surgeons completed a survey of clinical/radiographic case scenarios on patients with lumbar spondylolisthesis with neurogenic claudication with (S+BP) or without (S-BP) associated mechanical back pain...
December 27, 2017: World Neurosurgery
Permsak Paholpak, Emin Dedeogullari, Christopher Lee, Koji Tamai, Kaku Barkoh, Kittipong Sessumpun, Jeffrey C Wang, Zorica Buser
The objective of the study is to identified the correlation between Modic changes (MCs), disc degeneration, motions (translation and angulation) and facet osteoarthritis in lumbar spine. 425 patients who underwent multi-positional lumbar MRI were reviewed. A total of 2250 lumbar spinal segments in neutral position were evaluated for MCs, disc degeneration grading, translation and angulation motion, and facet osteoarthritis. The chi-square test, Kruskal-Wallis, Mann-Whitney U test, Pearson's correlation and linear regression were used to test for statistically significant difference between parameters...
January 2018: European Journal of Radiology
Kjersti Storheim, Ansgar Espeland, Lars Grøvle, Jan Sture Skouen, Jörg Aßmus, Audny Anke, Anne Froholdt, Linda M Pedersen, Anne Julsrud Haugen, Terese Fors, Elina Schistad, Olav Lutro, Gunn Hege Marchand, Thomas Kadar, Nils Vetti, Sigrun Randen, Øystein Petter Nygaard, Jens Ivar Brox, Margreth Grotle, John-Anker Zwart
BACKGROUND: A previous randomised controlled trial (RCT) of patients with chronic low back pain (LBP) and vertebral bone marrow (Modic) changes (MCs) on magnetic resonance imaging (MRI), reported that a 3-month, high-dose course of antibiotics had a better effect than placebo at 12 months' follow-up. The present study examines the effects of antibiotic treatment in chronic LBP patients with MCs at the level of a lumbar disc herniation, similar to the previous study. It also aims to assess the cost-effectiveness of the treatment, refine the MRI assessment of MCs, and further evaluate the impact of the treatment and the pathogenesis of MCs by studying genetic variability and the gene and protein expression of inflammatory biomarkers...
December 15, 2017: Trials
Gaurav Gupta, Peter Jarzem, Sean Meredith, Mohan Radhakrishna, Markus Besemann, Maria Francisca Elgueta, Roshanak Charghi, Jeffrey Chankowsky
PURPOSE: To determine the clinical effect of antibiotic treatment for patients with low back pain and Modic 1 changes. METHODS: This is a retrospective case series of patients treated at the Canadian Forces Health Services Centre in Ottawa and the McGill University Health Centre. Where available, pain, functional, and imaging outcomes in 11 patients treated between 2013 and 2015 were analyzed to determine effect of antibiotic treatment for patients with low back pain and associated Modic 1 changes on magnetic resonance imaging...
October 2017: U.S. Army Medical Department Journal
Aleksandra Sadowska, Ermioni Touli, Wolfgang Hitzl, Helen Greutert, Stephen J Ferguson, Karin Wuertz-Kozak, Oliver N Hausmann
PURPOSE: To investigate and compare the occurrence of inflammatory processes in the sites of disc degeneration in the lumbar and cervical spine by a gene array and subsequent qPCR and to investigate the mechanistic involvement of transient receptor potential channels TRPC6 and TRPV4. METHODS: The gene expression of inflammatory cytokines and TRP channels was measured in human disc samples obtained from patients undergoing discectomy at the cervical (n = 24) or lumbar (n = 27) spine for degenerative disc disease (DDD) and disc herniation (DH) and analyzed for differences with regard to spinal level, IVD degeneration grade, Modic grade, age, sex, disc region and surgical extent...
March 2018: European Spine Journal
Dominik Nabergoj, Petra Modic, Aleš Podgornik
It is important to understand how physiological state of the host influence propagation of bacteriophages (phages), due to the potential higher phage production needs in the future. In our study, we tried to elucidate the effect of bacterial growth rate on adsorption constant (δ), latent period (L), burst size (b), and bacteriophage population growth rate (λ). As a model system, a well-studied phage T4 and Escherichia coli K-12 as a host was used. Bacteria were grown in a continuous culture operating at dilution rates in the range between 0...
December 1, 2017: MicrobiologyOpen
Tim Finkenstaedt, Filippo Del Grande, Nicolae Bolog, Nils Ulrich, Sina Tok, Orpheus Kolokythas, Johann Steurer, Gustav Andreisek, Sebastian Winklhofer
PURPOSE:  To assess the performance of fat-suppressed fluid-sensitive MRI sequences compared to T1-weighted (T1w) / T2w sequences for the detection of Modic 1 end-plate changes on lumbar spine MRI. MATERIALS AND METHODS:  Sagittal T1w, T2w, and fat-suppressed fluid-sensitive MRI images of 100 consecutive patients (consequently 500 vertebral segments; 52 female, mean age 74 ± 7.4 years; 48 male, mean age 71 ± 6.3 years) were retrospectively evaluated...
February 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Nelson Astur, Delio E Martins, Marcelo Wajchenberg, Mario Ferretti, Fernando G Menezes, Andre M Doi, Laercio A Rosemberg, Durval C B Santos, Alexandre S Iutaka, Luciano M R Rodrigues, Marines D V Martino, Jorge R Pagura, Eduardo N Kihara Filho, Mario Lenza
INTRODUCTION: Low back pain and vertebral endplate abnormalities are common conditions within the population. Subclinical infection caused by indolent pathogens can potentially lead to these findings, with differentiation between them notably challenging from a clinical perspective. Progressive infection of the intervertebral disc has been extensively associated with increasing low back pain, with Propionibacterium acnes specifically implicated with in relation to sciatica. The main purpose of this study is to identify if the presence of an infective pathogen within the intervertebral disc is primary or is a result of intraoperative contamination, and whether this correlates to low back pain...
November 17, 2017: BMJ Open
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