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https://www.readbyqxmd.com/read/28535556/feasibility-of-percutaneous-lumbar-discectomy-combined-with-percutaneous-cementoplasty-for-symptomatic-lumbar-disc-herniation-with-modic-type-i-endplate-changes
#1
Qing-Hua Tian, Ying-Ying Lu, Xi-Qi Sun, Tao Wang, Chun-Gen Wu, Ming-Hua Li, Sheng Cheng-Ying
BACKGROUND: Treatment of symptomatic lumbar disc herniation with Modic type I endplate changes is complex and challenging, requiring systemic and local therapies which include conservative therapy, epidural infiltrations, percutaneous therapeutic techniques, and surgical options. The clinical management of symptomatic lumbar disc herniation involving Modic type I endplate changes is uniquely challenging because it requires alleviating pain caused by both the herniated disc and the endplate osteochondritis...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28496357/incidence-and-risk-factors-of-persistent-low-back-pain-following-posterior-decompression-and-instrumented-fusion-for-lumbar-disk-herniation
#2
Hui Wang, Tao Wang, Qian Wang, Wenyuan Ding
INTRODUCTION: The aim of this study was to explore the incidence and risk factors of persistent low back pain (PLBP) following posterior decompression and instrumented fusion for lumbar disk herniation and to provide references in decision-making and surgical planning for both spinal surgeons and surgically treated patients. PATIENTS AND METHODS: By retrieving the medical records from January 2013 to December 2016, 221 patients were retrospectively reviewed. Patients were classified as having PLBP if numeric rating scale (NRS) scores were >50 at all postoperative follow-up time points (3 months, 6 months, and 12 months)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28496192/magnetic-field-tuning-of-an-excitonic-insulator-between-the-weak-and-strong-coupling-regimes-in-quantum-limit-graphite
#3
Z Zhu, R D McDonald, A Shekhter, B J Ramshaw, K A Modic, F F Balakirev, N Harrison
The excitonic insulator phase has long been predicted to form in proximity to a band gap opening in the underlying band structure. The character of the pairing is conjectured to crossover from weak (BCS-like) to strong coupling (BEC-like) as the underlying band structure is tuned from the metallic to the insulating side of the gap opening. Here we report the high-magnetic field phase diagram of graphite to exhibit just such a crossover. By way of comprehensive angle-resolved magnetoresistance measurements, we demonstrate that the underlying band gap opening occurs inside the magnetic field-induced phase, paving the way for a systematic study of the BCS-BEC-like crossover by means of conventional condensed matter probes...
May 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28485657/mri-findings-in-lumbar-spine-following-o2-o3-chemiodiscolysis-a-long-term-follow-up
#4
Federico Bruno, Fernando Smaldone, Marco Varrassi, Francesco Arrigoni, Antonio Barile, Ernesto Di Cesare, Carlo Masciocchi, Alessandra Splendiani
Intradiscal O2-O3 injections are conventionally used as a minimally invasive treatment for lumbar disc herniation in patients not responding to conservative treatments. The aim of the present study is to report data of long-term imaging follow-up (3 years) of patients treated with intradiscal O2-O3 lumbar chemiodiscolysis. We evaluated the changes of disc volume and the modifications in disc appearance (in terms of disc degeneration) and endplate changes (according to Modic), comparing the results with a control group of patients...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28473342/prevalence-of-traumatic-findings-on-routine-mri-in-a-large-cohort-of-professional-fighters
#5
J K Lee, J Wu, S Banks, C Bernick, M G Massand, M T Modic, P Ruggieri, S E Jones
BACKGROUND AND PURPOSE: Previous studies investigating MR imaging abnormalities among fighters have had small sample sizes. This investigation assessed a large number of fighters using the same conventional sequences on the same scanner. MATERIALS AND METHODS: Conventional 3T MR imaging was used to assess 499 fighters (boxers, mixed martial artists, and martial artists) and 62 controls for nonspecific WM changes, cerebral microhemorrhage, cavum septum pellucidum, and cavum vergae...
May 4, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28472000/must-read-books-for-your-bookshelf-or-digital-device-part-2
#6
Mary Beth Modic
No abstract text is available yet for this article.
May 2017: Journal for Nurses in Professional Development
https://www.readbyqxmd.com/read/28467899/high-resolution-rna-maps-suggest-common-principles-of-splicing-and-polyadenylation-regulation-by-tdp-43
#7
Gregor Rot, Zhen Wang, Ina Huppertz, Miha Modic, Tina Lenče, Martina Hallegger, Nejc Haberman, Tomaž Curk, Christian von Mering, Jernej Ule
Many RNA-binding proteins (RBPs) regulate both alternative exons and poly(A) site selection. To understand their regulatory principles, we developed expressRNA, a web platform encompassing computational tools for integration of iCLIP and RNA motif analyses with RNA-seq and 3' mRNA sequencing. This reveals at nucleotide resolution the "RNA maps" describing how the RNA binding positions of RBPs relate to their regulatory functions. We use this approach to examine how TDP-43, an RBP involved in several neurodegenerative diseases, binds around its regulated poly(A) sites...
May 2, 2017: Cell Reports
https://www.readbyqxmd.com/read/28453429/anti-microbial-coating-innovations-to-prevent-infectious-diseases-amici-cost-action-ca15114
#8
Colum P Dunne, Minna M Keinänen-Toivola, Anne Kahru, Birgit Teunissen, Hulya Olmez, Isabel Gouveia, Luis Melo, Kazimierz Murzyn, Martina Modic, Merja Ahonen, Pete Askew, Theofilos Papadopoulos, Christian Adlhart, Francy R L Crijns
Worldwide, millions of patients are affected annually by healthcare-associated infection (HCAI), impacting up to 80,000 patients in European Hospitals on any given day. This represents not only public health risk, but also an economic burden. Complementing routine hand hygiene practices, cleaning and disinfection, antimicrobial coatings hold promise based, in essence, on the application of materials and chemicals with persistent bactericidal or -static properties onto surfaces or in textiles used in healthcare environments...
April 28, 2017: Bioengineered
https://www.readbyqxmd.com/read/28433838/outcome-of-anterior-lumbar-interbody-fusion-a-retrospective-study-of-clinical-and-radiological-parameters
#9
H Pinson, G Hallaert, P Herregodts, K Everaert, T Couvreur, J Caemaert, J P Kalala, D Van Roost
OBJECTIVE: This study aims to critically evaluate the long-term results of stand-alone anterior lumbar interbody fusion (ALIF), without use of rhBMP-2, as a therapeutic option for symptomatic patients with degenerative disc disease (DDD). Furthermore this study intends to identify predictive parameters for anterior lumbar interbody fusion outcome. METHODS: A retrospective cohort study with additional telephone interview to obtain missing data was performed. All patients who underwent a L4-L5 and/or L5-S1 ALIF-procedure in the period between 2006 and 2011 were identified...
April 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28431955/the-course-of-modic-vertebral-body-changes-after-posterolateral-lumbar-fusion-on-fused-and-adjacent-levels-a-systematic-review-of-the-literature
#10
REVIEW
Stella Taylor Portella, Marcus André Acioly
According to the original description by Modic et al., the natural course of bone marrow signal abnormalities is an inexorable, progressive one, however recent evidence has demonstrated in healthy individuals and those suffering from lumbar disc herniation that the course of endplate degenerative changes is rather dynamic and sometimes regressive. The evolution of such changes in lumbar fused segments and adjacent levels is largely unknown. The literature relevant to the course of Modic changes on fused and adjacent levels, as well as its clinical correspondence in patients undergoing posterolateral lumbar fusion was collected...
April 18, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28421295/do-modic-changes-affect-cervical-sagittal-alignment-and-motion-in-symptomatic-patients
#11
Tong Tong, Xian-Da Gao, Jia Li, Jing-Tao Zhang, Rui-Jie Niu, Zhao Liu, Yong Shen
PURPOSE: The cervical segmental instability often occurs simultaneously with Modic changes (MCs). However, it is unknown whether there is a relation between the two diseases. The aim of this study was to evaluate the relationship between MCs and cervical segmental instability, cervical curvature and range of motion (ROM) in the cervical spine. METHODS: A total of 464 patients with neck pain or cervical neurologic symptoms who underwent imaging examination were analyzed retrospectively...
April 18, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28402320/prevalence-of-modic-changes-in-the-lumbar-vertebrae-and-their-associations-with-workload-smoking-and-weight-in-northern-china
#12
Chao Han, Ming-Jie Kuang, Jian-Xiong Ma, Xin-Long Ma
The distribution of Modic changes (MCs) in the lumbar endplates and the evaluation of the relationships between MCs and risk factors are vital for research into MCs. The T1-weighted and T2-weighted sagittal MRI scans of 210 patients who exhibited lumbar intervertebral disc degeneration were retrospectively reviewed. The patients' weights, genders, smoking statuses, physical activity levels and specific types of MC were recorded. The associations between MCs and risk factors, such as physical work, smoking and body mass index, were also analysed...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28402132/modic-type-1-vertebral-endplate-changes-injury-inflammation-or-infection
#13
Matthew Thomas Crockett, Brendan Sean Kelly, Susie van Baarsel, Eoin Carl Kavanagh
OBJECTIVE: In the 29 years since the initial description of Modic type 1 vertebral endplate changes there has been ongoing debate regarding their cause. Studies have attributed Modic type 1 vertebral endplate changes to traumatic injury to the vertebral endplate, localized action of proinflammatory mediators, and more recently low-grade bacterial infection. Can we reconcile these conflicting data about the underlying cause of Modic type 1 vertebral endplate changes? Are we now in a position to conclude whether Modic type 1 vertebral endplate changes are secondary to injury, inflammation, or infection? CONCLUSION: We argue that the processes are not disparate but are in fact closely linked, each potentially instigating a chain of events leading to the MRI findings of Modic type 1 vertebral endplate change...
April 12, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28399545/propionibacterium-acnes-incubation-in-the-discs-can-result-in-time-dependent-modic-changes-a-long-term-rabbit-model
#14
Zhi Shan, Xuyang Zhang, Shengyun Li, Tianming Yu, Junhui Liu, Fengdong Zhao
STUDY DESIGN: A case control study of animal model of Modic changes (MCs) on Rabbits. OBJECTIVE: To evaluate the feasibility of inducing of MCs by injection of Propionibacterium acne (P. acnes) into the lumbar intervertebral discs of rabbits. SUMMARY OF BACKGROUND DATA: MCs have been widely observed, and assume to be closely associated with low back pain and P. acnes, but there are few animal models showing the progression of MCs. METHODS: Ten rabbits were used for the study...
April 10, 2017: Spine
https://www.readbyqxmd.com/read/28394776/correlation-analysis-between-modic-change-of-cervical-vertebrae-and-intramedullary-high-signal-intensity
#15
Hao Zhou, Jin Fan, Peng Sun, Wei Zhou, Qingqing Li, Lipeng Yu, Guoyong Yin
PURPOSE: Clinical studies have shown that endplate Modic change in the cervical spine and intramedullary high signal intensity often occurs simultaneously. We aimed to investigate whether there is a correlation between Modic change and intramedullary high signal intensity, and to explore the possible risk factors. MATERIALS AND METHODS: In total, 133 patients with cervical spondylotic myelopathy treated at the First Affiliated Hospital of Nanjing Medical University between May 2009 and March 2013 were enrolled in the study...
April 7, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28377243/hybrid-bone-spect-ct-imaging-in-evaluation-of-chronic-low-back-pain-correlation-with-modic-changes-and-degenerative-disc-disease
#16
Vittorio M Russo, Ranju T Dhawan, Nishanth Dharmarajah, I Baudracco, Antonio I Lazzarino, Adrian T Casey
BACKGROUND CONTEXT: Multiple radiological modalities are used in the evaluation of patients with low back pain (LBP). Only limited evidence currently exists to support the use of Bone HDP (hydroxydiphosphonate) SPECT/CT (Single Photon Emission Computed Tomography) in patients with Modic changes (MC) and degenerative disc disease (DDD). PURPOSE: The aim of this study was to assess the value of the hybrid Bone SPECT/CT imaging in patients with chronic low back pain...
April 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28321567/adjacent-segment-pathology-natural-history-or-effect-of-anterior-cervical-discectomy-and-fusion-a-10-year-follow-up-radiological-multicenter-study-using-an-evaluation-scale-of-the-ageing-spine
#17
Alessandro Pesce, Venceslao Wierzbicki, Emanuele Piccione, Alessandro Frati, Antonino Raco, Riccardo Caruso
PURPOSE: Aim of this study is to compare late degenerative MRI changes in a subset of patients operated on with ACDF to a second subset of patients presenting indication to ACDF but never operated on. METHODS: Patients from both subgroups received surgical indication according to the same criteria. Both subgroups underwent a cervical spine MRI in 2004-2005 and 10 years later in 2015. These MRI scans were retrospectively evaluated with a cervical spine ageing scale...
March 20, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28291179/the-influence-of-direct-inoculation-of-propionibacterium-acnes-on-modic-changes-in-the-spine-evidence-from-a-rabbit-model
#18
Zhi Shan, Xuyang Zhang, Shengyun Li, Tianming Yu, Maiwulanjiang Mamuti, Fengdong Zhao
BACKGROUND: Modic changes (inflammatory-like changes visible on magnetic resonance imaging [MRI] scans of a vertebral end plate) are common and are associated with low back pain, but their origin is unclear. To our knowledge, there have been no previous in vivo animal models of Modic changes. We hypothesized that Modic changes may be related to Propionibacterium acnes. METHODS: Ten New Zealand White rabbits were injected percutaneously with 1 mL of P. acnes (1.6 × 10 colony forming units/mL) into the subchondral bone superior to the L4-L5 and L5-L6 discs; 10 other control rabbits received sham injections at L4-L5 and 1 mL of normal saline solution (vehicle) at L5-L6...
March 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28253483/factors-that-influence-recurrent-lumbar-disc-herniation
#19
M E Yaman, A Kazancı, N D Yaman, F Baş, G Ayberk
INTRODUCTION: The most common cause of poor outcome following lumbar disc surgery is recurrent herniation. Recurrence has been noted in 5% to 15% of patients with surgically treated primary lumbar disc herniation. There have been many studies designed to determine the risk factors for recurrent lumbar disc herniation. In this study, we retrospectively analysed the influence of disc degeneration, endplate changes, surgical technique, and patient's clinical characteristics on recurrent lumbar disc herniation...
March 3, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28252490/must-read-books-for-your-bookshelf-or-digital-device-part-1
#20
Mary Beth Modic
No abstract text is available yet for this article.
March 2017: Journal for Nurses in Professional Development
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