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Andrew J Teichtahl, Donna M Urquhart, Yuanyuan Wang, Anita E Wluka, Richard O'Sullivan, Graeme Jones, Flavia M Cicuttini
BACKGROUND: Degenerative disc disease of the lumbar spine is common, with severe disease increasing the risk for chronic low back pain. This cross-sectional study examined whether disc degeneration is representative of a 'whole-organ' pathology, by examining its association with bone (vertebral endplate) and soft tissue (paraspinal muscle fat) abnormalities. METHODS: Seventy-two community-based individuals unselected for low back pain, had Magnetic Resonance Imaging (MRI)...
October 21, 2016: BMC Musculoskeletal Disorders
Joyce J Fitzpatrick, Mary Beth Modic, Jennifer Van Dyk, K Kelly Hancock
OBJECTIVE: The Leadership Education and Development (LEAD) Program was designed to transform care at the bedside by empowering clinical nurses as leaders. BACKGROUND: The heart of LEAD was enhancing communication skills of clinical nurses with clinical colleagues and, most importantly, patients and families. Key concepts of leadership/management were included: personal awareness, personal leadership skills/abilities, leading change, leading others individually and in teams, enhancing the patient/provider experience, and the leadership role in outcomes management...
October 12, 2016: Journal of Nursing Administration
Erik V de Kelft
STUDY DESIGN: This is a feasibility study to confirm the design, patient population, and the surgical technique for FENIX implants. OBJECTIVE: This study evaluated the safety and the clinical and radiologic performance of bilaterally implanted FENIX facet resurfacing device. INTRODUCTION: Facet joint osteoarthritis is responsible for up to 30% of chronic low back pain. Arthroplasty is a surgical treatment option that aims to relieve pain while maintaining or restoring motion...
November 2016: Clinical Spine Surgery
Martin Barth, Johann Fontana, Claudius Thomé, Gerrit J Bouma, Kirsten Schmieder
Sequestrectomy alone represents a procedure for the treatment of lumbar disc herniation. For selected cases, an anulus closure device (ACD) can be implanted which may result in lower reoperation rates. However, comparative magnetic resonance imaging (MRI) changes and their clinical relevance of both procedures are unclear and have not been reported so far. Clinical and MRI data of patients after limited discectomy with ACD implantation (group ACD; N=45) and patients after sequestrectomy alone (group S; N=40) with primary lumbar disc herniation were compared retrospectively...
October 11, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Chao Han, Tao Wang, Hong-Qiang Jiang, Jian-Xiong Ma, Peng Tian, Jia-Cheng Zang, Xin-Long Ma
The establishment of Modic changes (MCs) in animal model was vital for research of MCs. Fifty-four rabbits were divided into a sham group, a muscle embedment group (ME group) and nucleus pulposus (NP) embedment group (NPE group). In the NPE group, the discs were exposed by the lumbar anterolateral surgical approach. A needle was used to puncture the L5 vertebral body close to the endplate. NP was extracted by a syringe from L1/2 intervertebral discs and then injected into the drilled hole of subchondral bone...
October 7, 2016: Scientific Reports
Nadja A Farshad-Amacker, Alexander Hughes, Richard J Herzog, Burkhardt Seifert, Mazda Farshad
OBJECTIVES: The association of disc degeneration (DD) and vertebral endplate degeneration (EPD) is still not well understood. This study aimed to find segmental predictive risk factors for DD and EPD and to illuminate associations of the disc, endplate and bone marrow changes in the process of degeneration. METHODS: After institutional review board approval, 450 lumbar levels, followed up with MRI for at least 4 years, were retrospectively graded for DD according to Pfirrmann (PFG), for EPD according to the endplate score (EPS) and according to the presence, extension and type of Modic changes (MC)...
October 5, 2016: European Radiology
Hye Jin Yoo, Sung Hwan Hong, Dong Hyun Kim, Ja-Young Choi, Hee Dong Chae, Bo Mi Jeong, Joong Mo Ahn, Heung Sik Kang
PURPOSE: To determine whether fat-signal-fraction (FF) map using a modified Dixon sequence could help differentiate benign from malignant bone lesions. MATERIALS AND METHODS: Spine magnetic resonance images (MRIs) of 120 consecutive patients were studied by using a 3T MRI with standard T1 -weighted image (T1 WI) and modified-Dixon sequence for FF measurement. There were three groups: a control group (n = 51) with normal vertebrae; a benign group (n = 40) with focal red marrow deposition, Schmorl's nodes, benign compression fracture, or Modic type 1 endplate degeneration; a malignant group (n = 29) with spinal malignancies...
September 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
Michel Kressig, Cynthia K Peterson, Kyle McChurch, Christof Schmid, Serafin Leemann, Bernard Anklin, B Kim Humphreys
OBJECTIVE: The purpose of this study was to evaluate whether cervical disk herniation (CDH) location, morphology, or Modic changes (MCs) are related to treatment outcomes. METHODS: Magnetic resonance imaging (MRI) and outcome data from 44 patients with CDH treated with spinal manipulative therapy were evaluated. MRI scans were assessed for CDH axial location, morphology, and MCs. Pain (0-10 for neck and arm) and Neck Disability Index (NDI) data were collected at baseline; 2 weeks; 1, 3, and 6 months; and 1 year...
September 26, 2016: Journal of Manipulative and Physiological Therapeutics
Masatoshi Teraguchi, Dino Samartzis, Hiroshi Hashizume, Hiroshi Yamada, Shigeyuki Muraki, Hiroyuki Oka, Jason Pui Yin Cheung, Ryohei Kagotani, Hiroki Iwahashi, Sakae Tanaka, Hiroshi Kawaguchi, Kozo Nakamura, Toru Akune, Kenneth Man-Chee Cheung, Noriko Yoshimura, Munehito Yoshida
INTRODUCTION: High intensity zones (HIZ) of the lumbar spine are a phenotype of the intervertebral disc noted on MRI whose clinical relevance has been debated. Traditionally, T2-weighted (T2W) magnetic resonance imaging (MRI) has been utilized to identify HIZ of lumbar discs. However, controversy exists with regards to HIZ morphology, topography, and association with other MRI spinal phenotypes. Moreover, classification of HIZ has not been thoroughly defined in the past and the use of additional imaging parameters (e...
2016: PloS One
Mary Beth Modic
No abstract text is available yet for this article.
September 2016: Journal for Nurses in Professional Development
Stephan Becker, Alexander Hadjipavlou, Michael H Heggeness
BACKGROUND CONTENT: Lumbar axial back pain arising from degenerative disc disease continues to be a challenging clinical problem whether treated with non-surgical management, local injection, or motion segment stabilization and fusion. PURPOSE: To determine the efficacy of intraosseous basivertebral nerve ablation for the treatment of chronic lumbar back pain in a clinical setting. STUDY DESIGN: Patients meeting predefined inclusion/exclusion criteria were enrolled in a study using RF energy to ablate the basivertebral nerve within the vertebral bodies adjacent to the diagnosed level...
September 1, 2016: Spine Journal: Official Journal of the North American Spine Society
Yuan Yao, Huan Liu, Huiyu Zhang, Honggang Wang, Zhengfeng Zhang, Yangyi Zheng, Yu Tang, Yue Zhou
BACKGROUND: Microendoscopic discectomy (MED) has been widely accepted for its advantage of minimal injury in the treatment of lumbar disc herniation (LDH). Recurrence after successful MED has been reported, however, the risk factors responsible for the MED recurrence were still unclear. METHODS: From April 2005 to April 2016, 111 patients with recurrent herniation after successful MED were included in this retrospective study. Kaplan-Meier methods and Cox regression analysis were used to identify the significant risk factors responsible for MED recurrence...
August 24, 2016: World Neurosurgery
Juhani H Määttä, Alex MacGregor, Jaro Karppinen, Frances M K Williams
BACKGROUND: Recent reported results have added to the weight of evidence supporting association between disc degeneration and Modic changes. Endplate or Modic changes are also associated with increased body mass index. The most recent study from Teichtahl et al. titled 'Modic changes in the lumbar spine and their association with body composition, fat distribution and intervertebral disc height - a 3.0 T-MRI study' showed associations of Modic changes with quantitatively measured reduced disc height and fat mass index...
2016: BMC Musculoskeletal Disorders
Dick J Zeilstra, Victor E Staartjes, Marc L Schröder
PURPOSE: Our aim was to evaluate mid- and long-term results in a cohort of patients who underwent minimally invasive transaxial lumbosacral fixation and to identify clinical and other parameters that can aid in proper patient selection. METHODS: Over a period of ten years, we assessed 164 patients who had a complete follow-up of a minimum of one year (average 54 months). On follow-up, we recorded clinical status, fusion status, visual analogue scale (VAS), Oswestry Lower Back Pain Disability Index (ODI) scores and patient satisfaction...
August 23, 2016: International Orthopaedics
Philip J W Moll, Andrew C Potter, Nityan L Nair, B J Ramshaw, K A Modic, Scott Riggs, Bin Zeng, Nirmal J Ghimire, Eric D Bauer, Robert Kealhofer, Filip Ronning, James G Analytis
Electrons in materials with linear dispersion behave as massless Weyl- or Dirac-quasiparticles, and continue to intrigue due to their close resemblance to elusive ultra-relativistic particles as well as their potential for future electronics. Yet the experimental signatures of Weyl-fermions are often subtle and indirect, in particular if they coexist with conventional, massive quasiparticles. Here we show a pronounced anomaly in the magnetic torque of the Weyl semimetal NbAs upon entering the quantum limit state in high magnetic fields...
2016: Nature Communications
C Canal, M Modic, U Cvelbar, M-P Ginebra
Calcium phosphate (CaP) ceramics are of interest in bone substitution due to their good biocompatibility and bioresorbability. Currently certain CaPs in the market are loaded with antibiotics in order to prevent infections but further control is needed over antibiotic release patterns. Cold plasmas have emerged as a useful means of modifying the interactions with drugs through surface modification of polymer materials. In this work we explore the possibility of using atmospheric pressure plasmas as a tool for the surface modification of these CaP materials with newly populated bonds and charges, with views on enabling higher loading and controlled drug release...
October 20, 2016: Biomaterials Science
S Rajasekaran, Rishi Mugesh Kanna, Ranjani Raja Reddy, Senthil Natesan, Muthuraja Raveendran, Kenneth Mc Cheung, Danny Chan, Patrick Yp Kao, Anita Yee, Ajoy Prasad Shetty
STUDY DESIGN: Prospective genetic association study OBJECTIVE.: To document the variations in the genetic associations, when different MRI phenotypes, age stratification, cohort size and sequence of cohort inclusion are varied in the same study population. SUMMARY OF BACKGROUND DATA: Genetic associations with disc degeneration have shown high inconsistency, generally attributed to hereditary factors and ethnic variations. However the effect of different phenotypes, size of the study population, age of the cohort etc have not been documented clearly...
August 10, 2016: Spine
Gregory D Schroeder, Dessislava Z Markova, John D Koerner, Jeffery A Rihn, Alan S Hilibrand, Alexander R Vaccaro, D Greg Anderson, Christopher K Kepler
OF BACKGROUND DATA: Degenerative changes including Modic Changes (MCs) are commonly observed in patients with chronic low back pain. Although intervertebral disc (IVD) cytokine expression has been shown to be associated with low back pain, the cytokine profile for degenerative IVD with and without MC has not been compared. PURPOSE: To evaluate the potential association between intervertebral disc cytokine expression and MCs. STUDY DESIGN: Laboratory Study METHODS: The IVD from ten patients with Type II MCs and ten patients without MCs who underwent an anterior lumbar interbody and fusion for significant low back pain were collected...
August 4, 2016: Spine Journal: Official Journal of the North American Spine Society
Courtney A Wilson, Darren M Roffey, Donald Chow, Fahad Alkherayf, Eugene K Wai
BACKGROUND CONTEXT: Sciatica is often caused by a herniated lumbar intervertebral disc. When conservative treatment fails, a lumbar discectomy can be performed. Surgical treatment via lumbar discectomy is not always successful and may depend on a variety of preoperative factors. It remains unclear which, if any, preoperative factors can predict postsurgical clinical outcomes. PURPOSE: This review aimed to determine preoperative predictors that are associated with postsurgical clinical outcomes in patients undergoing lumbar discectomy...
August 4, 2016: Spine Journal: Official Journal of the North American Spine Society
Connor Wathen, Varun Kshettry, Ajit Krishnaney, Steven M Gordon, Thomas Fraser, Edward C Benzel, Michael T Modic, Sam Butler, Andre G Machado
BACKGROUND: Surgical site infection (SSI) contributes significantly to postoperative morbidity and mortality and greatly increases the cost of care. OBJECTIVE: To identify the impact of workflow and personnel-related risk factors contributing to the incidence of SSIs in a large sample of neurological surgeries. METHODS: Data were obtained using an enterprisewide electronic health record system, operating room, and anesthesia records for neurological procedures conducted between January 1, 2009, and November 30, 2012...
July 25, 2016: Neurosurgery
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