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https://www.readbyqxmd.com/read/29297602/effect-of-zoledronic-acid-and-denosumab-in-patients-with-low-back-pain-and-modic-change-a-proof-of-principle-trial
#1
Guoqi Cai, Laura L Laslett, Dawn Aitken, Andrew Halliday, Feng Pan, Petr Otahal, Deborah Speden, Tania M Winzenberg, Graeme Jones
The aim of this study was to evaluate the effect of zoledronic acid (ZA) and denosumab on low back pain (LBP) and Modic change (MC) over 6 months. Adults aged ≥40 years with significant LBP for at least 6 months duration and MC (type 1, 2 or mixed) were randomised to receive ZA (5mg/100ml), denosumab (60mg), or placebo. LBP was measured monthly by Visual Analogue Scale (VAS) and the LBP Rating Scale (RS). MC was measured from MRIs of T12-S1 vertebrae at screening and 6 months. 103 participants with moderate/severe LBP (mean VAS=57mm, mean RS=18) and median total MC area 538 mm2 , were enrolled...
January 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29288862/variability-in-surgical-treatment-of-spondylolisthesis-among-spine-surgeons
#2
Daniel Lubelski, Vincent Alentado, Seth Williams, Colin O'Rourke, Nancy Obuchowski, Jeffrey C Wang, Michael Steinmetz, Alfred Melillo, Edward Benzel, Michael Modic, Robert Quencer, Thomas Mroz
BACKGROUND: There are a multitude of treatments for low grade lumbar spondylolisthesis. There are no clear guidelines for the optimal approach. OBJECTIVE: To identify the surgical treatment patterns for spondylolisthesis, among United States spine surgeons METHODS: 445 US spine surgeons completed a survey of clinical/radiographic case scenarios on patients with lumbar spondylolisthesis with neurogenic claudication with (S+BP) or without (S-BP) associated mechanical back pain...
December 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29279162/do-modic-changes-disc-degeneration-translation-and-angular-motion-affect-facet-osteoarthritis-of-the-lumbar-spine
#3
Permsak Paholpak, Emin Dedeogullari, Christopher Lee, Koji Tamai, Kaku Barkoh, Kittipong Sessumpun, Jeffrey C Wang, Zorica Buser
The objective of the study is to identified the correlation between Modic changes (MCs), disc degeneration, motions (translation and angulation) and facet osteoarthritis in lumbar spine. 425 patients who underwent multi-positional lumbar MRI were reviewed. A total of 2250 lumbar spinal segments in neutral position were evaluated for MCs, disc degeneration grading, translation and angulation motion, and facet osteoarthritis. The chi-square test, Kruskal-Wallis, Mann-Whitney U test, Pearson's correlation and linear regression were used to test for statistically significant difference between parameters...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29246188/antibiotic-treatment-in-patients-with-chronic-low-back-pain-and-modic-changes-the-aim-study-study-protocol-for-a-randomised-controlled-trial
#4
Kjersti Storheim, Ansgar Espeland, Lars Grøvle, Jan Sture Skouen, Jörg Aßmus, Audny Anke, Anne Froholdt, Linda M Pedersen, Anne Julsrud Haugen, Terese Fors, Elina Schistad, Olav Lutro, Gunn Hege Marchand, Thomas Kadar, Nils Vetti, Sigrun Randen, Øystein Petter Nygaard, Jens Ivar Brox, Margreth Grotle, John-Anker Zwart
BACKGROUND: A previous randomised controlled trial (RCT) of patients with chronic low back pain (LBP) and vertebral bone marrow (Modic) changes (MCs) on magnetic resonance imaging (MRI), reported that a 3-month, high-dose course of antibiotics had a better effect than placebo at 12 months' follow-up. The present study examines the effects of antibiotic treatment in chronic LBP patients with MCs at the level of a lumbar disc herniation, similar to the previous study. It also aims to assess the cost-effectiveness of the treatment, refine the MRI assessment of MCs, and further evaluate the impact of the treatment and the pathogenesis of MCs by studying genetic variability and the gene and protein expression of inflammatory biomarkers...
December 15, 2017: Trials
https://www.readbyqxmd.com/read/29214613/antibiotics-in-the-treatment-of-patients-with-lower-back-pain-associated-with-modic-changes-a-case-series
#5
Gaurav Gupta, Peter Jarzem, Sean Meredith, Mohan Radhakrishna, Markus Besemann, Maria Francisca Elgueta, Roshanak Charghi, Jeffrey Chankowsky
PURPOSE: To determine the clinical effect of antibiotic treatment for patients with low back pain and Modic 1 changes. METHODS: This is a retrospective case series of patients treated at the Canadian Forces Health Services Centre in Ottawa and the McGill University Health Centre. Where available, pain, functional, and imaging outcomes in 11 patients treated between 2013 and 2015 were analyzed to determine effect of antibiotic treatment for patients with low back pain and associated Modic 1 changes on magnetic resonance imaging...
October 2017: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/29204735/inflammaging-in-cervical-and-lumbar-degenerated-intervertebral-discs-analysis-of-proinflammatory-cytokine-and-trp-channel-expression
#6
Aleksandra Sadowska, Ermioni Touli, Wolfgang Hitzl, Helen Greutert, Stephen J Ferguson, Karin Wuertz-Kozak, Oliver N Hausmann
PURPOSE: To investigate and compare the occurrence of inflammatory processes in the sites of disc degeneration in the lumbar and cervical spine by a gene array and subsequent qPCR and to investigate the mechanistic involvement of transient receptor potential channels TRPC6 and TRPV4. METHODS: The gene expression of inflammatory cytokines and TRP channels was measured in human disc samples obtained from patients undergoing discectomy at the cervical (n = 24) or lumbar (n = 27) spine for degenerative disc disease (DDD) and disc herniation (DH) and analyzed for differences with regard to spinal level, IVD degeneration grade, Modic grade, age, sex, disc region and surgical extent...
December 4, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29195013/effect-of-bacterial-growth-rate-on-bacteriophage-population-growth-rate
#7
Dominik Nabergoj, Petra Modic, Aleš Podgornik
It is important to understand how physiological state of the host influence propagation of bacteriophages (phages), due to the potential higher phage production needs in the future. In our study, we tried to elucidate the effect of bacterial growth rate on adsorption constant (δ), latent period (L), burst size (b), and bacteriophage population growth rate (λ). As a model system, a well-studied phage T4 and Escherichia coli K-12 as a host was used. Bacteria were grown in a continuous culture operating at dilution rates in the range between 0...
December 1, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/29179238/modic-type-1-changes-detection-performance-of-fat-suppressed-fluid-sensitive-mri-sequences
#8
Tim Finkenstaedt, Filippo Del Grande, Nicolae Bolog, Nils Ulrich, Sina Tok, Orpheus Kolokythas, Johann Steurer, Gustav Andreisek, Sebastian Winklhofer
Purpose To assess the performance of fat-suppressed fluid-sensitive MRI sequences compared to T1-weighted (T1w) / T2w sequences for the detection of Modic 1 end-plate changes on lumbar spine MRI. Materials and Methods Sagittal T1w, T2w, and fat-suppressed fluid-sensitive MRI images of 100 consecutive patients (consequently 500 vertebral segments; 52 female, mean age 74 ± 7.4 years; 48 male, mean age 71 ± 6.3 years) were retrospectively evaluated. We recorded the presence (yes/no) and extension (i...
November 27, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29151051/subclinical-propionibacterium-acnes-infection-estimation-in-the-intervertebral-disc-spine-id-protocol-for-a-prospective-cohort
#9
Nelson Astur, Delio E Martins, Marcelo Wajchenberg, Mario Ferretti, Fernando G Menezes, Andre M Doi, Laercio A Rosemberg, Durval C B Santos, Alexandre S Iutaka, Luciano M R Rodrigues, Marines D V Martino, Jorge R Pagura, Eduardo N Kihara Filho, Mario Lenza
INTRODUCTION: Low back pain and vertebral endplate abnormalities are common conditions within the population. Subclinical infection caused by indolent pathogens can potentially lead to these findings, with differentiation between them notably challenging from a clinical perspective. Progressive infection of the intervertebral disc has been extensively associated with increasing low back pain, with Propionibacterium acnes specifically implicated with in relation to sciatica. The main purpose of this study is to identify if the presence of an infective pathogen within the intervertebral disc is primary or is a result of intraoperative contamination, and whether this correlates to low back pain...
November 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/29141001/the-associations-between-magnetic-resonance-imaging-findings-and-low-back-pain-a-10-year-longitudinal-analysis
#10
Juichi Tonosu, Hiroyuki Oka, Akiro Higashikawa, Hiroshi Okazaki, Sakae Tanaka, Ko Matsudaira
PURPOSE: To conduct a 10-year longitudinal analysis of the relationship between magnetic resonance imaging (MRI) findings and low back pain (LBP). MATERIALS AND METHODS: Ninety-one volunteers with a history of LBP, but without current LBP were recruited between 2005 and 2006. Participants' baseline demographics and MRI findings were recorded. All volunteers were invited for a follow-up MRI in 2016; of these, 49 volunteers (53.8%) participated in the follow-up. We enquired whether they had LBP history during the 10 years between the baseline and follow-up examinations...
2017: PloS One
https://www.readbyqxmd.com/read/29118795/cost-analysis-of-the-addition-of-hyperacute-magnetic-resonance-imaging-for-selection-of-patients-for-endovascular-stroke-therapy
#11
Seby John, Nicolas R Thompson, Terry Lesko, Nancy Papesh, Nancy Obuchowski, Dan Tomic, Dolora Wisco, Zeshaun Khawaja, Ken Uchino, Shumei Man, Esteban Cheng-Ching, Gabor Toth, Thomas Masaryk, Paul Ruggieri, Michael Modic, Muhammad Shazam Hussain
Background and Purpose: Patient selection is important to determine the best candidates for endovascular stroke therapy. In application of a hyperacute magnetic resonance imaging (MRI) protocol for patient selection, we have shown decreased utilization with improved outcomes. A cost analysis comparing the pre- and post-MRI protocol time periods was performed to determine if the previous findings translated into cost opportunities. Materials and Methods: We retrospectively identified individuals considered for endovascular stroke therapy from January 2008 to August 2012 who were ≤8 h from stroke symptoms onset...
October 2017: Interventional Neurology
https://www.readbyqxmd.com/read/29103126/lumbar-total-disc-replacement-predictors-for-long-term-outcome
#12
Håvard Furunes, Christian Hellum, Jens Ivar Brox, Ivar Rossvoll, Ansgar Espeland, Linda Berg, Helga Maria Brøgger, Milada Cvancarova Småstuen, Kjersti Storheim
PURPOSE: We aimed to identify patient characteristics associated with favourable long-term outcomes after lumbar total disc replacement (TDR). METHODS: We analysed a cohort of 82 patients with degenerative disc and chronic low back pain (LBP) who were treated with TDR and originally participated in a randomised trial comparing TDR and multidisciplinary rehabilitation. Potential predictors were measured at baseline, and the outcomes assessed 8 years after they received allocated treatment...
November 4, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29095221/last-word
#13
Mary Beth Modic
No abstract text is available yet for this article.
November 2017: Journal for Nurses in Professional Development
https://www.readbyqxmd.com/read/29069048/predictive-factors-associated-with-neck-pain-in-patients-with-cervical-disc-degeneration-a-cross-sectional-study-focusing-on-modic-changes
#14
Lingde Kong, Weifeng Tian, Peng Cao, Haonan Wang, Bing Zhang, Yong Shen
The predictive factors associated with neck pain remain unclear. We conducted a cross-sectional study to assess predictive factors, especially Modic changes (MCs), associated with the intensity and duration of neck pain in patients with cervical disc degenerative disease.We retrospectively reviewed patients in our hospital from January 2013 to December 2016. Severe neck pain (SNP) and persistent neck pain (PNP) were the 2 main outcomes, and were assessed based on the numerical rating scale (NRS). Basic data, and also imaging data, were collected and analyzed as potential predictive factors...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29032381/analysis-of-correlation-between-vertebral-endplate-change-and-lumbar-disc-degeneration
#15
Long Xiao, Chunlin Ni, Jiandong Shi, Zhirong Wang, Suchun Wang, Jianwei Zhang, Aiqing Lu
BACKGROUND To evaluate the correlation between vertebral endplate change and the level of lumbar disc degeneration via magnetic resonance imaging (MRI). MATERIAL AND METHODS A total of 345 patients who were recruited from our hospital from May 2012 to May 2016 were evaluated for the presence of intervertebral disc degeneration or herniation. The degree of degeneration was assessed according to Pfirrmann grade. Vertebral endplate change was evaluated based on the endplate concave angle (ECA), and Modic change on sagittal MRI...
October 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29029200/lateral-cerebellar-nucleus-stimulation-has-selective-effects-on-glutamatergic-and-gabaergic-perilesional-neurogenesis-after-cortical-ischemia-in-the-rodent-model
#16
Hugh H Chan, Jessica Cooperrider, Zhihong Chen, John T Gale, Kenneth B Baker, Connor A Wathen, Claire R Modic, Hyun-Joo Park, Andre G Machado
BACKGROUND: Chronic deep brain stimulation of the rodent lateral cerebellar nucleus (LCN) has been demonstrated to enhance motor recovery following cortical ischemia. This effect is concurrent with synaptogenesis and expression of long-term potentiation markers in the perilesional cerebral cortex. OBJECTIVE: To further investigate the cellular changes associated with chronic LCN stimulation in the ischemic rodent by examining neurogenesis along the cerebellothalamocortical pathway...
September 27, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29019806/lumbar-vertebral-endplate-defects-on-magnetic-resonance-images-classification-distribution-patterns-and-associations-with-modic-changes-and-disc-degeneration
#17
Zhiyun Feng, Yuanhao Liu, Ge Yang, Michele C Battié, Yue Wang
STUDY DESIGN: A cross-sectional MR imaging study. OBJECTIVE: To classify and characterize endplate defects using routine lumbar MR images, and to determine associations of endplate defects with Modic Changes (MCs) and disc degeneration. SUMMARY OF BACKGROUND DATA: Previously, a cadaveric study revealed that endplate lesions were common and associated with back pain history. New in vivo approaches appropriate for clinical studies are needed to further this potentially important line of research on the clinical significance of endplate lesions, including their relation with MCs, disc degeneration and back pain...
October 10, 2017: Spine
https://www.readbyqxmd.com/read/29019804/quantification-of-propionic-acid-in-the-bovine-spinal-disk-after-infection-of-the-tissue-with-p-acnes-bacteria
#18
Sergey Magnitsky, Stefan Dudli, Xinyan Tang, Jaskanwaljeet Kaur, Joycelyn Diaz, Steve Miller, Jeffrey C Lotz
STUDY DESIGN: Research OBJECTIVE.: The goal of this study was to investigate whether P. acnes infection of the intervertebral disc can be detected noninvasively by NMR spectroscopy. SUMMARY OF BACKGROUND DATA: Microbiological studies of surgical samples suggest that a significant subpopulation of back pain patients may have occult disc infection with P. acnes bacteria. This hypothesis is further supported by a double-blind clinical trial showing that back pain patients with Modic type 1 changes may respond to antibiotic treatment...
October 10, 2017: Spine
https://www.readbyqxmd.com/read/28985974/what-is-the-role-of-the-bacterium-propionibacterium-acnes-in-type-1-modic-changes-a-review-of-the-literature
#19
REVIEW
Mark Georgy, Mark Stern, Kieran Murphy
This review presents a summary of the pathology and epidemiology of Modic changes and the possible role of Propionibacterium acnes. This information is followed by a synthesis of the most recent clinical research involved in culturing the discs of patients with degenerative disc disease for the presence of bacteria. We also discuss a randomized controlled trial that investigates the effects of antibiotics on patients with chronic low back pain and type 1 Modic changes. We conclude with a brief discussion of the difficulties involved in this research and the significance of the findings...
November 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28967575/-assessment-of-the-correlation-between-histological-degeneration-and-radiological-and-clinical-parameters-in-a-series-of-patients-who-underwent-lumbar-disc-herniation-surgery
#20
Pablo M Munarriz, Igor Paredes, José F Alén, Ana M Castaño-Leon, Santiago Cepeda, Aurelio Hernandez-Lain, Alfonso Lagares
BACKGROUND AND OBJECTIVE: The use of histological degeneration scores in surgically-treated herniated lumbar discs is not common in clinical practice and its use has been primarily restricted to research. The objective of this study is to evaluate if there is an association between a higher grade of histological degeneration when compared with clinical or radiological parameters. PATIENTS AND METHOD: Retrospective consecutive analysis of 122 patients who underwent single-segment lumbar disc herniation surgery...
September 26, 2017: Neurocirugía
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