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https://www.readbyqxmd.com/read/28321567/adjacent-segment-pathology-natural-history-or-effect-of-anterior-cervical-discectomy-and-fusion-a-10-year-follow-up-radiological-multicenter-study-using-an-evaluation-scale-of-the-ageing-spine
#1
Alessandro Pesce, Venceslao Wierzbicki, Emanuele Piccione, Alessandro Frati, Antonino Raco, Riccardo Caruso
PURPOSE: Aim of this study is to compare late degenerative MRI changes in a subset of patients operated on with ACDF to a second subset of patients presenting indication to ACDF but never operated on. METHODS: Patients from both subgroups received surgical indication according to the same criteria. Both subgroups underwent a cervical spine MRI in 2004-2005 and 10 years later in 2015. These MRI scans were retrospectively evaluated with a cervical spine ageing scale...
March 20, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28291179/the-influence-of-direct-inoculation-of-propionibacterium-acnes-on-modic-changes-in-the-spine-evidence-from-a-rabbit-model
#2
Zhi Shan, Xuyang Zhang, Shengyun Li, Tianming Yu, Maiwulanjiang Mamuti, Fengdong Zhao
BACKGROUND: Modic changes (inflammatory-like changes visible on magnetic resonance imaging [MRI] scans of a vertebral end plate) are common and are associated with low back pain, but their origin is unclear. To our knowledge, there have been no previous in vivo animal models of Modic changes. We hypothesized that Modic changes may be related to Propionibacterium acnes. METHODS: Ten New Zealand White rabbits were injected percutaneously with 1 mL of P. acnes (1.6 × 10 colony forming units/mL) into the subchondral bone superior to the L4-L5 and L5-L6 discs; 10 other control rabbits received sham injections at L4-L5 and 1 mL of normal saline solution (vehicle) at L5-L6...
March 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28253483/factors-that-influence-recurrent-lumbar-disc-herniation
#3
M E Yaman, A Kazancı, N D Yaman, F Baş, G Ayberk
INTRODUCTION: The most common cause of poor outcome following lumbar disc surgery is recurrent herniation. Recurrence has been noted in 5% to 15% of patients with surgically treated primary lumbar disc herniation. There have been many studies designed to determine the risk factors for recurrent lumbar disc herniation. In this study, we retrospectively analysed the influence of disc degeneration, endplate changes, surgical technique, and patient's clinical characteristics on recurrent lumbar disc herniation...
March 3, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28252490/must-read-books-for-your-bookshelf-or-digital-device-part-1
#4
Mary Beth Modic
No abstract text is available yet for this article.
March 2017: Journal for Nurses in Professional Development
https://www.readbyqxmd.com/read/28214695/the-effects-of-atmospheric-pressure-cold-plasma-treatment-on-microbiological-physical-chemical-and-sensory-characteristics-of-vacuum-packaged-beef-loin
#5
A Bauer, Y Ni, S Bauer, P Paulsen, M Modic, J L Walsh, F J M Smulders
Effects on vacuum packaged and non-packaged beef longissimus samples exposed to atmospheric cold plasma (ACP) generated at different powers were studied over a 10day period of vacuum-, and a subsequent 3day period of aerobic storage. Exposure of non-covered beef samples under high power ACP conditions resulted in increased a*, b*, Chroma and Hue values, but ACP treatment of packaged loins did not impact colour (L*, a*, b*, Chroma, Hue), lipid peroxidation, sarcoplasmic protein denaturation, nitrate/nitrite uptake, or myoglobin isoform distribution...
February 8, 2017: Meat Science
https://www.readbyqxmd.com/read/28206726/are-modic-type-2-disc-changes-associated-with-low-grade-infections-a-pilot-study
#6
Lorenzo Drago, Carlo L Romanò, Riccardo Cecchinato, Jorge H Villafañe, Elena De Vecchi, Claudio Lamartina, Pedro Berjano
BACKGROUND: The aim of this study is to compare intra-operative cultural examination in patients undergoing elective surgery for low-back pain with Modic 2 changes to patients without Modic signs. The aim of this study is to compare intra-operative cultural examination in patients undergoing elective surgery for low-back pain with Modic 2 changes to patients without Modic signs. METHODS: Sixteen patients with Modic 2 changes were compared with 23 patients without Modic signs...
February 15, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28168339/automation-of-reading-of-radiological-features-from-magnetic-resonance-images-mris-of-the-lumbar-spine-without-human-intervention-is-comparable-with-an-expert-radiologist
#7
Amir Jamaludin, Meelis Lootus, Timor Kadir, Andrew Zisserman, Jill Urban, Michele C Battié, Jeremy Fairbank, Iain McCall
STUDY DESIGN: Investigation of the automation of radiological features from magnetic resonance images (MRIs) of the lumbar spine. OBJECTIVE: To automate the process of grading lumbar intervertebral discs and vertebral bodies from MRIs. MR imaging is the most common imaging technique used in investigating low back pain (LBP). Various features of degradation, based on MRIs, are commonly recorded and graded, e.g., Modic change and Pfirrmann grading of intervertebral discs...
February 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28161488/cold-atmospheric-pressure-plasma-elimination-of-clinically-important-single-and-mixed-species-biofilms
#8
Martina Modic, Neil P McLeod, J Mark Sutton, James L Walsh
Mixed-species biofilms reflect the natural environment of many pathogens in clinical settings and are highly resistant to disinfection methods. An indirect cold atmospheric-pressure air-plasma system was evaluated under two different discharge conditions for its ability to kill representative Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa) pathogens. Plasma treatment of individual 24-h-old biofilms and mixed-species biofilms that contained additional species (Enterococcus faecalis and Klebsiella pneumoniae) was considered...
March 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28158154/percutaneous-vertebroplasty-for-symptomatic-schmorl-s-nodes-11-cases-with-long-term-follow-up-and-a-literature-review
#9
Shi-Cheng He, Bin-Yan Zhong, Hai-Dong Zhu, Wen Fang, Li Chen, Jin-He Guo, Gang Deng, Gao-Jun Teng
BACKGROUND: Percutaneous vertebroplasty (PVP) is commonly used to treat symptomatic vertebral compression fractures. However, its long-term effectiveness and safety for use in the treatment of symptomatic Schmorl's nodes (SNs) refractory to conservative treatment is uncertain. OBJECTIVES: To present a case series with PVP for symptomatic SNs not responding to conservative therapy and assess the effectiveness and safety for such treatment with long-term follow-up...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28150049/expert-s-comment-concerning-grand-rounds-case-entitled-rehydration-of-a-degenerated-disc-on-mri-synchronized-with-transition-of-modic-changes-following-stand-alone-xlif-by-k-kita-t-sakai-m-abe-y-takata-and-k-sairyo-eur-spine-j-2017-doi-10-1007-s00586-017-4945
#10
https://www.readbyqxmd.com/read/28144734/rehydration-of-a-degenerated-disc-on-mri-synchronized-with-transition-of-modic-changes-following-stand-alone-xlif
#11
Kenichiro Kita, Toshinori Sakai, Mitsunobu Abe, Yoichiro Takata, Koichi Sairyo
Lumbar intervertebral disc degeneration (LDD) is known to be associated with low back pain (LBP) and leads to degenerative lumbar disease. LDD is considered to be irreversible, and no truly effective treatment that suppresses LDD or regenerates the degenerated disc has been established thus far. Here, we report the case of a 42-year-old woman with a 10-year history of persistent LBP. Magnetic resonance imaging (MRI) demonstrated degenerative changes (Pfirrmann classification: grade IV) in the L4-5 intervertebral disc with type I and III mixed Modic changes adjacent to the disc...
January 31, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28138783/intervertebral-disc-bone-marrow-cross-talk-with-modic-changes
#12
Stefan Dudli, David C Sing, Serena S Hu, Sigurd H Berven, Shane Burch, Vedat Deviren, Ivan Cheng, Bobby K B Tay, Todd F Alamin, Ma Agnes Martinez Ith, Eric M Pietras, Jeffrey C Lotz
STUDY DESIGN: Cross-sectional cohort analysis of patients with Modic Changes (MC). OBJECTIVE: Our goal was to characterize the molecular and cellular features of MC bone marrow and adjacent discs. We hypothesized that MC associate with biologic cross-talk between discs and bone marrow, the presence of which may have both diagnostic and therapeutic implications. BACKGROUND DATA: MC are vertebral bone marrow lesions that can be a diagnostic indicator for discogenic low back pain...
January 31, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28127375/predictors-of-reoperation-after-microdecompression-in-lumbar-spinal-stenosis
#13
Hee-Jong Hwang, Hyung-Ki Park, Gwang-Soo Lee, June-Young Heo, Jae-Chil Chang
OBJECTIVE: The risk factors of reoperation after microdecompression (MD) for lumbar spinal stenosis (LSS) are unclear. In this study, we presented the outcomes of MD for degenerative LSS and investigated the risk factors associated with reoperation. METHODS: A retrospective review was conducted using the clinical records and radiographs of patients with LSS who underwent MD. For clinical evaluation, we used the Japanese Orthopedic Association (JOA) scoring system for low back pain, body mass index, and Charlson comorbidity index...
December 2016: Korean Journal of Spine
https://www.readbyqxmd.com/read/28125437/value-in-single-level-lumbar-discectomy-surgical-disposable-item-cost-and-relationship-to-patient-reported-outcomes
#14
Benjamin P Rosenbaum, Michael T Modic, Ajit A Krishnaney
STUDY DESIGN: This is a retrospective study. OBJECTIVE: Compare improvements in health status measures (HSMs) and surgical costs to determine whether use of more costly items has any relationship to clinical outcome and value in lumbar disc surgery. SUMMARY OF BACKGROUND DATA: Association between cost, outcomes, and value in spine surgery, including lumbar discectomy is poorly understood. Outcomes were calculated as difference in mean HSM scores between preoperative and postoperative timeframes...
January 25, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28114923/intervertebral-disc-and-vertebral-endplate-subchondral-changes-associated-with-modic-1-changes-of-the-lumbar-spine-a-cross-sectional-study
#15
Christelle Nguyen, Marylène Jousse, Serge Poiraudeau, Antoine Feydy, François Rannou
BACKGROUND: Modic 1 changes are usually associated with degenerative disc disease (DDD). We aimed to compare Modic 1 changes with advanced degenerative disc disease (>50%-intervertebral space narrowing [IVSN]) to Modic 1 changes with less advanced lumbar degenerative disc disease (≤50%-IVSN). METHODS: We conducted a cross-sectional study. The computerized MRI database from a French tertiary care hospital was searched. Patients were included if they were ≥ 18 years old and had a lumbar MRI between January 1, 2006 and January 31, 2008, that showed a Modic 1 signal at a single level...
January 23, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28081267/single-nucleotide-variants-of-candidate-genes-in-aggrecan-metabolic-pathway-are-associated-with-lumbar-disc-degeneration-and-modic-changes
#16
Romain Shanil Perera, Poruwalage Harsha Dissanayake, Upul Senarath, Lalith Sirimevan Wijayaratne, Aranjan Lional Karunanayake, Vajira Harshadeva Weerabaddana Dissanayake
INTRODUCTION: Lumbar disc degeneration (LDD) is genetically determined and severity of LDD is associated with Modic changes. Aggrecan is a major proteoglycan in the intervertebral disc and end plate. Progressive reduction of aggrecan is a main feature of LDD and Modic changes. OBJECTIVES: The study investigated the associations of single nucleotide variants (SNVs) of candidate genes in the aggrecan metabolic pathway with the severity of LDD and Modic changes. In-silico functional analysis of significant SNVs was also assessed...
2017: PloS One
https://www.readbyqxmd.com/read/28043884/risk-factors-for-the-recurrent-herniation-after-percutaneous-endoscopic-lumbar-discectomy
#17
Yuan Yao, Huan Liu, Huiyu Zhang, Honggang Wang, Chao Zhang, Zhengfeng Zhang, Junlong Wu, Yu Tang, Yue Zhou
BACKGROUND: Percutaneous endoscopic lumbar discectomy (PELD) has been widely used for treating lumbar disc herniation (LDH). Recurrence after PELD has been reported, but few studies have focused on the risk factors responsible for PELD recurrence. METHODS: From March 2005 to March 2016, 116 patients suffering from recurrent herniation after successful PELD were enrolled in this retrospective study. Kaplan-Meier methods and Cox regression analysis were employed to identify the significant risk factors predicting PELD recurrence...
December 30, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28031964/10-years-of-research-from-ignoring-modic-changes-to-considerations-regarding-treatment-and-prevention-of-low-grade-disc-infections
#18
EDITORIAL
Claus Manniche, Alan Jordan
No abstract text is available yet for this article.
June 2016: Future Science OA
https://www.readbyqxmd.com/read/27997510/a-whole-exome-study-identifies-novel-candidate-genes-for-vertebral-bone-marrow-signal-changes-modic-changes
#19
Minna Kraatari, Sini Skarp, Niinimäki Jaakko, Jaro Karppinen, Minna Männikkö
STUDY DESIGN: Family-based study OBJECTIVE.: To identify rare genetic factors predisposing to Modic changes (MC). SUMMARY OF BACKGROUND DATA: Lumbar disc degeneration (LDD) is one of the contributing factors behind low back pain (LBP). Lumbar MC visualized as bone marrow signal intensity changes on magnetic resonance imaging (MRI) represent a specific phenotype of LDD, which has stronger association with LBP than LDD without MC. METHODS: The study set consisted of two Finnish families: Family I included seven affected and four unaffected individuals and Family II eight affected and seven unaffected individuals...
December 16, 2016: Spine
https://www.readbyqxmd.com/read/27917347/identification-of-lumbar-disc-disease-hallmarks-a-large-cross-sectional-study
#20
Jun Zhang, Fei Zhao, Feng-Liang Wang, Yong-Feng Yang, Chen Zhang, Yue Cao, You-Lin Wang, Xiao-Juan Shi, Yi Wan, Min Zhang, Meng-Qiao Liu, Chun-Guang Zuo, Hai-Qiang Wang
BACKGROUND: Lumbar disc disease has a disabling impact on global people with heavy burden on society, mainly consisting of lumbar disc degeneration (LDD) and lumbar disc herniation (LDH). The recently released lumbar disc nomenclature version 2.0 deepens our understandings on the diseases. Consequently, there is an urgent need to clarify the occurrence and distribution features of LDD and LDH in a large-scale sample in terms of the novel version. QUESTION/PURPOSES: We asked: (1) Is there a difference in the occurrence and distribution hallmarks of LDD and LDH in a population-based large-scale sample? (2) Does the novel nomenclature version bring novel vision on lumbar disc disease? METHODS: Five thousand two hundred eighty-eight consecutive cases (26,440 lumbar discs) undergoing lumbar spine MRI were retrospectively included from Jan 2008 to Dec 2010 in a territory university hospital...
2016: SpringerPlus
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