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https://www.readbyqxmd.com/read/29141001/the-associations-between-magnetic-resonance-imaging-findings-and-low-back-pain-a-10-year-longitudinal-analysis
#1
Juichi Tonosu, Hiroyuki Oka, Akiro Higashikawa, Hiroshi Okazaki, Sakae Tanaka, Ko Matsudaira
PURPOSE: To conduct a 10-year longitudinal analysis of the relationship between magnetic resonance imaging (MRI) findings and low back pain (LBP). MATERIALS AND METHODS: Ninety-one volunteers with a history of LBP, but without current LBP were recruited between 2005 and 2006. Participants' baseline demographics and MRI findings were recorded. All volunteers were invited for a follow-up MRI in 2016; of these, 49 volunteers (53.8%) participated in the follow-up. We enquired whether they had LBP history during the 10 years between the baseline and follow-up examinations...
2017: PloS One
https://www.readbyqxmd.com/read/29118795/cost-analysis-of-the-addition-of-hyperacute-magnetic-resonance-imaging-for-selection-of-patients-for-endovascular-stroke-therapy
#2
Seby John, Nicolas R Thompson, Terry Lesko, Nancy Papesh, Nancy Obuchowski, Dan Tomic, Dolora Wisco, Zeshaun Khawaja, Ken Uchino, Shumei Man, Esteban Cheng-Ching, Gabor Toth, Thomas Masaryk, Paul Ruggieri, Michael Modic, Muhammad Shazam Hussain
Background and Purpose: Patient selection is important to determine the best candidates for endovascular stroke therapy. In application of a hyperacute magnetic resonance imaging (MRI) protocol for patient selection, we have shown decreased utilization with improved outcomes. A cost analysis comparing the pre- and post-MRI protocol time periods was performed to determine if the previous findings translated into cost opportunities. Materials and Methods: We retrospectively identified individuals considered for endovascular stroke therapy from January 2008 to August 2012 who were ≤8 h from stroke symptoms onset...
October 2017: Interventional Neurology
https://www.readbyqxmd.com/read/29103126/lumbar-total-disc-replacement-predictors-for-long-term-outcome
#3
Håvard Furunes, Christian Hellum, Jens Ivar Brox, Ivar Rossvoll, Ansgar Espeland, Linda Berg, Helga Maria Brøgger, Milada Cvancarova Småstuen, Kjersti Storheim
PURPOSE: We aimed to identify patient characteristics associated with favourable long-term outcomes after lumbar total disc replacement (TDR). METHODS: We analysed a cohort of 82 patients with degenerative disc and chronic low back pain (LBP) who were treated with TDR and originally participated in a randomised trial comparing TDR and multidisciplinary rehabilitation. Potential predictors were measured at baseline, and the outcomes assessed 8 years after they received allocated treatment...
November 4, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29095221/last-word
#4
Mary Beth Modic
No abstract text is available yet for this article.
November 2017: Journal for Nurses in Professional Development
https://www.readbyqxmd.com/read/29069048/predictive-factors-associated-with-neck-pain-in-patients-with-cervical-disc-degeneration-a-cross-sectional-study-focusing-on-modic-changes
#5
Lingde Kong, Weifeng Tian, Peng Cao, Haonan Wang, Bing Zhang, Yong Shen
The predictive factors associated with neck pain remain unclear. We conducted a cross-sectional study to assess predictive factors, especially Modic changes (MCs), associated with the intensity and duration of neck pain in patients with cervical disc degenerative disease.We retrospectively reviewed patients in our hospital from January 2013 to December 2016. Severe neck pain (SNP) and persistent neck pain (PNP) were the 2 main outcomes, and were assessed based on the numerical rating scale (NRS). Basic data, and also imaging data, were collected and analyzed as potential predictive factors...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29032381/analysis-of-correlation-between-vertebral-endplate-change-and-lumbar-disc-degeneration
#6
Long Xiao, Chunlin Ni, Jiandong Shi, Zhirong Wang, Suchun Wang, Jianwei Zhang, Aiqing Lu
BACKGROUND To evaluate the correlation between vertebral endplate change and the level of lumbar disc degeneration via magnetic resonance imaging (MRI). MATERIAL AND METHODS A total of 345 patients who were recruited from our hospital from May 2012 to May 2016 were evaluated for the presence of intervertebral disc degeneration or herniation. The degree of degeneration was assessed according to Pfirrmann grade. Vertebral endplate change was evaluated based on the endplate concave angle (ECA), and Modic change on sagittal MRI...
October 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29029200/lateral-cerebellar-nucleus-stimulation-has-selective-effects-on-glutamatergic-and-gabaergic-perilesional-neurogenesis-after-cortical-ischemia-in-the-rodent-model
#7
Hugh H Chan, Jessica Cooperrider, Zhihong Chen, John T Gale, Kenneth B Baker, Connor A Wathen, Claire R Modic, Hyun-Joo Park, Andre G Machado
BACKGROUND: Chronic deep brain stimulation of the rodent lateral cerebellar nucleus (LCN) has been demonstrated to enhance motor recovery following cortical ischemia. This effect is concurrent with synaptogenesis and expression of long-term potentiation markers in the perilesional cerebral cortex. OBJECTIVE: To further investigate the cellular changes associated with chronic LCN stimulation in the ischemic rodent by examining neurogenesis along the cerebellothalamocortical pathway...
September 27, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29019806/lumbar-vertebral-endplate-defects-on-magnetic-resonance-images-classification-distribution-patterns-and-associations-with-modic-changes-and-disc-degeneration
#8
Zhiyun Feng, Yuanhao Liu, Ge Yang, Michele C Battié, Yue Wang
STUDY DESIGN: A cross-sectional MR imaging study. OBJECTIVE: To classify and characterize endplate defects using routine lumbar MR images, and to determine associations of endplate defects with Modic Changes (MCs) and disc degeneration. SUMMARY OF BACKGROUND DATA: Previously, a cadaveric study revealed that endplate lesions were common and associated with back pain history. New in vivo approaches appropriate for clinical studies are needed to further this potentially important line of research on the clinical significance of endplate lesions, including their relation with MCs, disc degeneration and back pain...
October 10, 2017: Spine
https://www.readbyqxmd.com/read/29019804/quantification-of-propionic-acid-in-the-bovine-spinal-disk-after-infection-of-the-tissue-with-p-acnes-bacteria
#9
Sergey Magnitsky, Stefan Dudli, Xinyan Tang, Jaskanwaljeet Kaur, Joycelyn Diaz, Steve Miller, Jeffrey C Lotz
STUDY DESIGN: Research OBJECTIVE.: The goal of this study was to investigate whether P. acnes infection of the intervertebral disc can be detected noninvasively by NMR spectroscopy. SUMMARY OF BACKGROUND DATA: Microbiological studies of surgical samples suggest that a significant subpopulation of back pain patients may have occult disc infection with P. acnes bacteria. This hypothesis is further supported by a double-blind clinical trial showing that back pain patients with Modic type 1 changes may respond to antibiotic treatment...
October 10, 2017: Spine
https://www.readbyqxmd.com/read/28985974/what-is-the-role-of-the-bacterium-propionibacterium-acnes-in-type-1-modic-changes-a-review-of-the-literature
#10
REVIEW
Mark Georgy, Mark Stern, Kieran Murphy
This review presents a summary of the pathology and epidemiology of Modic changes and the possible role of Propionibacterium acnes. This information is followed by a synthesis of the most recent clinical research involved in culturing the discs of patients with degenerative disc disease for the presence of bacteria. We also discuss a randomized controlled trial that investigates the effects of antibiotics on patients with chronic low back pain and type 1 Modic changes. We conclude with a brief discussion of the difficulties involved in this research and the significance of the findings...
November 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28967575/-assessment-of-the-correlation-between-histological-degeneration-and-radiological-and-clinical-parameters-in-a-series-of-patients-who-underwent-lumbar-disc-herniation-surgery
#11
Pablo M Munarriz, Igor Paredes, José F Alén, Ana M Castaño-Leon, Santiago Cepeda, Aurelio Hernandez-Lain, Alfonso Lagares
BACKGROUND AND OBJECTIVE: The use of histological degeneration scores in surgically-treated herniated lumbar discs is not common in clinical practice and its use has been primarily restricted to research. The objective of this study is to evaluate if there is an association between a higher grade of histological degeneration when compared with clinical or radiological parameters. PATIENTS AND METHOD: Retrospective consecutive analysis of 122 patients who underwent single-segment lumbar disc herniation surgery...
September 26, 2017: Neurocirugía
https://www.readbyqxmd.com/read/28947993/the-value-of-radiographic-indexes-in-the-diagnosis-of-discogenic-low-back-pain-a-retrospective-analysis-of-imaging-results
#12
Jian Song, Hong-Li Wang, Xiao-Sheng Ma, Xin-Lei Xia, Fei-Zhou Lu, Chao-Jun Zheng, Jian-Yuan Jiang
To explore value of different radiographic indexes in the diagnosis of discogenic low back pain (LBP). A total number of 120 cases (60 patients diagnosed with discogenic LBP and 60 healthy people) were retrospectively analysed to identify factors in the diagnosis of discogenic LBP by using univariate and multivariate analyses. A receiver operating characteristic (ROC) curve was drew to show the predictive accuracy of the finally enrolled factors. Among all the included patients, 60 were strictly admitted in the discogenic LBP group while the other 60 were enrolled in the control group...
September 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937464/comparison-of-clinical-outcomes-after-anterior-cervical-discectomy-and-fusion-versus-cervical-total-disk-replacement-in-patients-with-modic-2-changes-on-mri
#13
Jia Li, Di Zhang, Wenyuan Ding, Yingze Zhang, Yong Shen
STUDY DESIGN: A retrospective investigation. OBJECTIVE: The aim of this research is to compare the clinical and radiologic outcomes of patients with Modic-2 changes who underwent anterior cervical discectomy and fusion (ACDF) or cervical total disk replacement (TDR) in single level. SUMMARY OF BACKGROUND DATA: There were few studies focused on the clinical and radiologic outcomes of patients with Modic-2 changes who underwent ACDF or cervical TDR in single level...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28900744/structural-vertebral-endplate-nomenclature-and-etiology-a-study-by-the-issls-spinal-phenotype-focus-group
#14
Uruj Zehra, Cora Bow, Jeffrey C Lotz, Frances M K Williams, S Rajasekaran, Jaro Karppinen, Keith D K Luk, Michele C Battiê, Dino Samartzis
PURPOSE: Vertebral endplate abnormalities may be associated with disc degeneration and, perhaps, pain generation. However, consensus definitions for endplate findings on spine MRI do not exist, posing a challenge to compare findings between studies and ethnic groups. The following survey was created to characterize the variability among the global spine community regarding endplate structural findings with respect to nomenclature and etiology. METHODS: A working group within the International Society for the Study of the Lumbar Spine (ISSLS) Spinal Phenotype Focus Group was established to assess the endplate phenotype...
September 12, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28894387/modic-changes-of-the-cervical-spine-t1-slope-and-its-impact-on-axial-neck-pain
#15
Jia Li, Shuhui Qin, Yongqian Li, Yong Shen
BACKGROUND: The purpose of the research was to evaluate cervical sagittal parameters on magnetic resonance imaging (MRI) in patients with Modic changes and its impact on axial neck pain. METHODS: This study consisted of 266 consecutive asymptomatic or symptomatic patients with Modic changes, whose average age was 50.9±12.6 years from January 2015 to December 2016. Cervical sagittal parameters included sagittal alignment of the cervical spine (SACS), T1 slope, thoracic inlet angle (TIA), and neck tilt (NT)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28891884/preceptorship-linguistic-upgrade
#16
Mary Beth Modic
No abstract text is available yet for this article.
September 2017: Journal for Nurses in Professional Development
https://www.readbyqxmd.com/read/28890222/identifying-subsets-of-patients-with-single-level-degenerative-disc-disease-for-lumbar-fusion-the-value-of-prognostic-tests-in-surgical-decision-making
#17
Victor E Staartjes, Pieter-Paul A Vergroesen, Dick J Zeilstra, Marc L Schröder
BACKGROUND CONTEXT: Fusion surgery for degenerative disc disease (DDD) has become a standard of care, albeit not without controversy. Outcomes are inconsistent and a superiority over conservative treatment is debatable. Proper patient selection is key to clinical success, and a comprehensive understanding of prognostic tests does not currently exist. PURPOSE: To investigate the value of prognostic tests and sociodemographic factors in predicting outcomes following lumbar fusion surgery for DDD...
September 7, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28884220/inflammatory-response-of-disc-cells-against-propionibacterium-acnes-depends-on-the-presence-of-lumbar-modic-changes
#18
Stefan Dudli, S Miller, S Demir-Deviren, J C Lotz
PURPOSE: Intervertebral disc with Propionibacterium acnes (P. acnes) is suggested to be an etiology of Modic type I changes in the adjacent bone marrow. However it is unknown if disc cells can respond to P. acnes and if bone marrow cells respond to bacterial and disc metabolites draining from infected discs. METHODS: Human disc cells (n = 10) were co-cultured with 10- and 100-fold excess of P. acnes over disc cells for 3 h and 24 h. Lipopolysaccharide was used as positive control...
September 7, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28874978/prevalence-patterns-and-genetic-association-analysis-of-modic-vertebral-endplate-changes
#19
Rishi Mugesh Kanna, Rajasekaran Shanmuganathan, Veera Ranjani Rajagopalan, Senthil Natesan, Raveendran Muthuraja, Kenneth Man Chee Cheung, Danny Chan, Patrick Yu Ping Kao, Anita Yee, Ajoy Prasad Shetty
STUDY DESIGN: A prospective genetic association study. PURPOSE: The etiology of Modic changes (MCs) is unclear. Recently, the role of genetic factors in the etiology of MCs has been evaluated. However, studies with a larger patient subset are lacking, and candidate genes involved in other disc degeneration phenotypes have not been evaluated. We studied the prevalence of MCs and genetic association of 41 candidate genes in a large Indian cohort. OVERVIEW OF LITERATURE: MCs are vertebral endplate signal changes predominantly observed in the lumbar spine...
August 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28856839/comparison-of-cauliflower-insect-fungus-interactions-and-pesticides-for-cabbage-root-fly-control
#20
Jaka Razinger, Metka Žerjav, Meta Zemljič-Urbančič, Špela Modic, Matthias Lutz, Hans-Josef Schroers, Jürg Grunder, Simon Fellous, Gregor Urek
Cabbage root fly (Delia radicum L.) control represents a major challenge in brassica production, therefore different management strategies for its control were tested in conventionally managed open field cauliflower production. Strategies included treatments with low risk methods such as nitrogen lime, the insecticide spinosad and the Beauveria bassiana ATCC 74040 based biopesticide Naturalis. Their effects were compared with treatments based on non-formulated fungal species Metarhizium brunneum, B. bassiana, Clonostachys solani, Trichoderma atroviride, T...
August 30, 2017: Insect Science
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