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https://www.readbyqxmd.com/read/29653432/in-vitro-evaluation-and-in-silico-studies-applied-on-newly-synthesized-amide-derivatives-of-n-phthaloylglycine-as-butyrylcholinesterase-bche-inhibitors
#1
Samreen Begum, Shaikh Sirajuddin Nizami, Uzma Mahmood, Summyia Masood, Sahar Iftikhar, Summayya Saied
Amide derivatives of N-phthaloylglycine were synthesized under Schotten Baumann reaction condition. The structures of synthesized compounds (4a-d) were characterized by using FTIR, 1 HNMR and EI-MS. The compounds were evaluated for their in-vitro Butyrylcholinesterase inhibition and all of them exhibited good activity against this enzyme. Compound 4a (IC50  = 6.5 ± 0.1) was found to be most potent compared with the reference compound Galantamine (IC50  = 6.6 ± 0.00038) and the other compounds (4b,4c,4d) were also possess that activity and hence can be employed for the discovery of lead compounds against Alzheimer's disease...
April 7, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29651999/photolithographic-stereolithographic-tandem-fabrication-of-4d-smart-scaffolds-for-improved-stem-cell-cardiomyogenic-differentiation
#2
Shida Miao, Haitao Cui, Margaret Nowicki, Se-Jun Lee, Jose Almeida, Xuan Zhou, Wei Zhu, Xiaoliang Yao, Fahed Masood, Michael W Plesniak, Muhammad Mohiuddin, Lijie Grace Zhang
4D printing is a highly innovative additive manufacturing process for fabricate smart structures with the ability to transform over time. Significantly different from regular 4D printing techniques, this study focuses on creating novel 4D hierarchical micropatterns using a unique photolithographic-stereolithographic-tandem strategy (PSTS) with smart soybean oil epoxidized acrylate (SOEA) inks for effectively regulating human bone marrow mesenchymal stem cell (hMSC) cardiomyogenic behaviors. The 4D effect refers to autonomous conversion of the surficial-patterned scaffold into a pre-designed construct through an external stimulus delivered immediately after printing...
April 13, 2018: Biofabrication
https://www.readbyqxmd.com/read/29651403/enhanced-wound-healing-after-leiomyoma-enucleation
#3
Masood Amini, Mohammad Hassan Hashemizadeh, Seyedeh Leila Poorbaghi
Leiomyoma is a rare esophageal tumor that constitutes less than 1% of esophageal malignancies. It should be removed when diagnosed even if asymptomatic. This study presents two cases of esophageal leiomyoma in 38 and 62 years old men who presented with dysphagia and evaluated for diagnosis and location of related tumors. Patients were clinically examined and upper gastrointestinal endoscopy, chest computerized tomography scan, barium swallow and endoscopic ultrasonography were performed. The masses were diagnosed and both patients underwent 3-port right videothoracoscopic enucleation of esophageal leiomyoma with sleeve calibration tube (SCT) assistance...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29643902/is-there-difference-in-chronic-pain-after-suture-and-stapler-fixation-method-of-mesh-in-ventral-hernia-is-stapler-fixation-method-quicker-a-randomized-controlled-trial
#4
Noureen Shaukat, Farhat Jaleel, Masood Jawaid, Imrana Zulfiqar
Background & Objective: Chronic pain occurs in 20-30% of patients after hernia surgery. As a consequence of this chronic pain, almost one third of patients have limitations in daily activities. Frequency and severity of this pain varies with different techniques of hernia repair. The objective of this study was to compare polypropylene suture and skin staples for securing mesh in uncomplicated ventral hernioplasty in terms of acute and chronic postoperative pain and to compare the time taken for mesh fixation between polypropylene sutures and skin stapler in ventral hernioplasty...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29629341/role-of-curcumin-in-disease-prevention-and-treatment
#5
REVIEW
Arshad Husain Rahmani, Mohammed A Alsahli, Salah M Aly, Masood A Khan, Yousef H Aldebasi
Treatment based on traditional medicine is very popular in developing world due to inexpensive properties. Nowadays, several types of preparations based on medicinal plants at different dose have been extensively recognized in the diseases prevention and treatment. In this vista, latest findings support the effect of Curcuma longa and its chief constituents curcumin in a broad range of diseases cure via modulation of physiological and biochemical process. In addition, various studies based on animal mode and clinical trials showed that curcumin does not cause any adverse complications on liver and kidney function and it is safe at high dose...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29627388/gaba-regulates-release-of-inflammatory-cytokines-from-peripheral-blood-mononuclear-cells-and-cd4-t-cells-and-is-immunosuppressive-in-type-1-diabetes
#6
Amol K Bhandage, Zhe Jin, Sergiy V Korol, Qiujin Shen, Yu Pei, Qiaolin Deng, Daniel Espes, Per-Ola Carlsson, Masood Kamali-Moghaddam, Bryndis Birnir
The neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule in the brain and in pancreatic islets. Here, we demonstrate that GABA regulates cytokine secretion from human peripheral blood mononuclear cells (PBMCs) and CD4+ T cells. In anti-CD3 stimulated PBMCs, GABA (100nM) inhibited release of 47 cytokines in cells from patients with type 1 diabetes (T1D), but only 16 cytokines in cells from nondiabetic (ND) individuals. CD4+ T cells from ND individuals were grouped into responder or non-responder T cells according to effects of GABA (100nM, 500nM) on the cell proliferation...
March 28, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29620490/comparative-study-of-the-interactions-between-bisphenol-a-and-its-endocrine-disrupting-analogues-with-bovine-serum-albumin-using-multi-spectroscopic-and-molecular-docking-studies
#7
Shoeb Ikhlas, Afia Usman, Masood Ahmad
Interaction studies of bisphenol analogues; Biphenol-A (BPA), Bisphenol-B (BPB) and Bisphenol-F (BPF) with bovine serum albumin (BSA) were performed using multi-spectroscopic and molecular docking studies at the protein level. The mechanism of binding of bisphenols with BSA was dynamic in nature. SDS refolding experiments demonstrated no stabilization of BSA structure denatured by BPB, however, BSA denatured by BPA and BPF was found to get stabilized. Also, CD spectra and molecular docking studies revealed that BPB bound more strongly and induced more conformational changes in BSA in comparison to BPA...
April 5, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29619147/translation-and-cross-cultural-adaptation-of-the-hip-disability-and-osteoarthritis-score-into-persian-language-reassessment-of-validity-and-reliability
#8
Alireza Mousavian, Amir Reza Kachooie, Ali Birjandinejad, Masood Khoshsaligheh, Mohammad Hosein Ebrahimzadeh
Background: This study aimed Persian translation and validation of the hip disability and osteoarthritis outcome score (HOOS) questionnaire. Methods: The study was carried out in two phases. First, we translated the HOOS according to acceptable guidelines. We assessed HOOS content convergent validity on 203 hip osteoarthritis patients using SF-36. Internal consistency was tested using Cronbach's alpha coefficient if each item removed and intraclass correlation coefficient (ICC) for the assessment of test-retest reproducibility...
2018: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29615180/a-case-of-vogt-koyanagi-harada-syndrome-mimicking-optic-neuritis
#9
Muhammad Mateen Amir, Atif Masood, Zarmina Khan
Vogt-Koyanagi-Harada syndrome is a rare disease that occurs commonly in pigmented individuals of Asian origin. A 25-year female presented in medical outpatient department (OPD) of Al-Khidmat Teaching Hospital, Mansoora, Lahore with headache and neck stiffness. She was referred to eye OPD for the complaint of decreased vision. On examination, there was 6/24 vision, sluggish pupillary reaction and disc hyperemia in both eyes. She was treated as a case of optic neuritis. Few days later, she developed bilateral panuveitis, shallow exudative detachments and alopecia...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29615170/disease-characteristics-and-treatment-outcome-of-testicular-germ-cell-tumors-treated-with-platinum-based-regimens
#10
Amir Sattar, Misbah Masood, Hasan Nisar, Ismat Fatima, Abu Baker Shahid
OBJECTIVE: To determine the disease characteristics of testicular germ cell tumor, biochemical/radiological response to chemotherapy and common toxicity profile. STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Institute of Nuclear Medicine and Oncology (INMOL), Lahore, from January 2010 to December 2013. METHODOLOGY: Fifty-one patients with histologically proven testicular germ cell tumor, who fulfilled the pre-defined eligibility criteria, were selected...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29613887/clinical-outcomes-and-reduced-pulmonary-artery-pressure-with-intra-aortic-balloon-pump-during-central-extracorporeal-life-support
#11
Sarah Tepper, Moises Baltazar Garcia, Irene Fischer, Amena Ahmed, Anam Khan, Keki R Balsara, Muhammad Faraz Masood, Akinobu Itoh
Patients supported with extracorporeal life support (ECLS) can experience severe complications from increased left ventricular afterload. The intra-aortic balloon pump (IABP) is thought to unload the left ventricle (LV) and is routinely used with ECLS despite conflicting evidence of its clinical benefit. This retrospective, single-center study examined the effect of the simultaneous use of IABP and centrally cannulated ECLS on patient outcomes and provides new insights into IABP-mediated LV unloading. Thirty patients supported with central ECLS and IABP (ECLS-I) were compared with 30 patients with central ECLS alone (ECLS) for cardiogenic shock...
March 30, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29611134/an-overview-of-the-genetics-of-plant-response-to-salt-stress-present-status-and-the-way-forward
#12
REVIEW
Fawad Kaleem, Ghulam Shabir, Kashif Aslam, Sumaira Rasul, Hamid Manzoor, Shahid Masood Shah, Abdul Rehman Khan
Salinity is one of the major threats faced by the modern agriculture today. It causes multidimensional effects on plants. These effects depend upon the plant growth stage, intensity, and duration of the stress. All these lead to stunted growth and reduced yield, ultimately inducing economic loss to the farming community in particular and to the country in general. The soil conditions of agricultural land are deteriorating at an alarming rate. Plants assess the stress conditions, transmit the specific stress signals, and then initiate the response against that stress...
April 2, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29607679/time-to-implement-a-national-referral-pathway-for-suspected-cauda-equina-syndrome-review-and-outcome-of-250-referrals
#13
Muhammad Masood Hussain, Adam Alexander Razak, Syed Sibet Hassan, Kishor A Choudhari, George Michael Spink
INTRODUCTION: Cauda equina syndrome (CES) is a condition with significant implications and medico-legal profile. The literature still lacks large primary studies to provide strong evidence for a robust management pathway. Statements from Neurosurgical and Spinal societies support early diagnosis and imaging but this has not resulted in any noticeable shift in referral pattern. We strongly feel the need for a nationally agreed, evidence-based referral pathway in practice. We present our large series and in-depth analysis of the referral pathway to provide strong evidence for more robust referrals and management...
April 2, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29607346/relationship-between-body-image-and-psychological-well-being-in-patients-with-morbid-obesity
#14
Negar Yazdani, Sayed Vahid Hosseini, Masood Amini, Zahra Sobhani, Farkhondeh Sharif, Hajar Khazraei
Background: Morbid obesity is rising around the world. It can cause unpleasant appearance and body image. Most of the studies have aimed to evaluate the psychopathology of overweight and obesity and paying attention to mental well-being in morbid obese individuals is rare. Therefore, this study aimed to assess the relationship between body image and psychological well-being in morbid obese patients. Methods: This cross-sectional study, using simple random sampling method, was done on 124 morbid obese patients who referred to obesity clinic in Shiraz from 2016 to 2017...
April 2018: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/29606938/spontaneous-hepatitis-b-seroclearance-upon-development-of-hepatocellular-carcinoma
#15
Sara Naimimohasses, Omar El Sherif, Mohammad Ashfaq, Niamh Nolan, Masood Iqbal, Susan McKiernan, Suzanne Norris
The spontaneous seroclearance of hepatitis B upon development of a hepatocellular carcinoma (HCC) is extremely rare. To date, there has been one published case series reporting hepatitis B seroconversion following HCC resection. We describe two novel cases of spontaneous hepatitis B seroclearance following the development of HCC, prior to resection. Following resection, specimens were HBsAg- and HBcAg-negative in both tumor and peritumor tissues. Although the precise mechanism of this is poorly understood, nonuniform integration of hepatitis B virus DNA within the liver could lead to selective tumorigenesis of HBsAg-producing cells, explaining the observed clearance of serum HBsAg with the development of HCC...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29604354/thrombin-like-enzymes-from-snake-venom-structural-characterization-and-mechanism-of-action
#16
REVIEW
Anwar Ullah, Rehana Masood, Ijaz Ali, Kifayat Ullah, Hamid Ali, Haji Akbar, Christian Betzel
Snake venom thrombin-like enzymes (SVTLEs) constitute the major portion (10-24%) of snake venom and these are the second most abundant enzymes present in the crude venom. During envenomation, these enzymes had shown prominently the various pathological effects, such as disturbance in hemostatic system, fibrinogenolysis, fibrinolysis, platelet aggregation, thrombosis, neurologic disorders, activation of coagulation factors, coagulant, procoagulant etc. These enzymes also been used as a therapeutic agent for the treatment of various diseases such as congestive heart failure, ischemic stroke, thrombotic disorders etc...
March 28, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29593914/rituximab-induced-pulmonary-edema-managed-with-extracorporeal-life-support
#17
Jacob R Miller, Warren Isakow, Muhammad F Masood, Patrick Aguilar, Kristen M Sanfilippo, Keki R Balsara, Akinobu Itoh
Though rare, rituximab has been reported to induce severe pulmonary edema. We describe the first report of ECLS utilization for this indication. A 31-year-old female with severe thrombotic thrombocytopenic purpura developed florid pulmonary edema after rituximab infusion. Despite advanced ventilatory settings, she developed severe respiratory acidosis and remained hypoxemic with a significant vasopressor requirement. Since her pulmonary insult was likely transient, ECLS was considered. Due to combined cardiorespiratory failure, she received support with peripheral venoarterial ECLS...
2018: Case Reports in Critical Care
https://www.readbyqxmd.com/read/29592809/exploring-the-potential-of-black-tea-based-flavonoids-against-hyperlipidemia-related-disorders
#18
Ali Imran, Masood Sadiq Butt, Muhammad Sajid Arshad, Muhammad Umair Arshad, Farhan Saeed, Muhammad Sohaib, Rizwan Munir
BACKGROUND: In recent decade, Hyperlipidemia related disorders like obesity, hypercholesterolemia and diabetes are considered as the leading killers for mankind. Fundamental nexus between nutrition and health diverting the consumers focus towards plant based natural products as a remedy against various metabolic syndrome. Considering this, present study was conducted to explicate the role of black tea polyphenols such as Theaflavins and thearubigins therapeutic potential to tackle targeted maladies especially oxidative stress related disorders like hypercholesterolemia and diabetes...
March 27, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29587523/assessment-of-electrocardiographic-criteria-of-left-atrial-enlargement
#19
Mahesh Kumar Batra, Atif Khan, Fawad Farooq, Tariq Masood, Musa Karim
Background Left atrial enlargement is considered to be a robust, strong, and widely acceptable indicator of cardiovascular outcomes. Echocardiography is the gold standard for measurement of left atrial size, but electrocardiography can be simple, cost-effective, and noninvasive in clinical practice. This study was undertaken to assess the diagnostic accuracy of an established electrocardiographic criterion for left atrial enlargement, taking 2-dimensional echocardiography as the gold-standard technique. Methods A cross-sectional study was conducted on 146 consecutively selected patients with the complaints of dyspnea and palpitation and with a murmur detected on clinical examination, from September 10, 2016 to February 10, 2017...
January 1, 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29584579/prevalence-of-pyrazinamide-resistance-in-khyber-pakhtunkhwa-pakistan
#20
Muhammad Tahir Khan, Shaukat Iqbal Malik, Sajid Ali, Anwar Sheed Khan, Tariq Nadeem, Muhammad Tariq Zeb, Nayyer Masood, Muhammad Tanvir Afzal
AIMS: Pyrazinamide (PZA) is an important component of first-line tuberculosis (TB) treatment because of its distinctive capability to kill subpopulations of persister Mycobacterium tuberculosis (MTB). The significance of PZA can be understood by its inclusion in the most recent World Health Organization-recommended multidrug-resistant (MDR) TB regimen. Very little information is available about the prevalence of PZA-resistant TB from geographically distinct regions of high burden countries, including Khyber Pakhtunkhwa (KPK), Pakistan, because drug susceptibility testing (DST) of PZA is not regularly performed due to the complexity...
March 27, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
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