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Muhammad Masood Khalid, Michael I Greenberg
No abstract text is available yet for this article.
February 16, 2018: Clinical Toxicology
Amin Allah Dashtiyan, Masood Sepehrimanesh, Nader Tanideh, Mohammad Esmaeil Afzalpour
The aim of this study was to investigate the effect of endurance training with and without vitamin E on the expression of p53 and Phosphatase and tension homolog (PTEN) tumor suppressor genes of prostate glands in male rats. For this purpose, 50 Sprague-Dawley male rats were randomly assigned into 5 groups: (1) control group (CON, n = 10), (2) sham (S, n = 10), (3) endurance training (ET, n = 10), (4) endurance training + vitamin E (ET + VE, n = 10), (5) vitamin E (VE, n = 10). Endurance training protocol was implemented for 6 weeks, 6 days per week, in accordance with the overload principle...
June 2017: Biochimie Open
Laia Caja, Kalliopi Tzavlaki, Mahsa S Dadras, E-Jean Tan, Gad Hatem, Naga P Maturi, Anita Morén, Lotta Wik, Yukihide Watanabe, Katia Savary, Masood Kamali-Moghaddan, Lene Uhrbom, Carl-Henrik Heldin, Aristidis Moustakas
Glioblastoma multiforme is a brain malignancy characterized by high heterogeneity, invasiveness, and resistance to current therapies, attributes related to the occurrence of glioma stem cells (GSCs). Transforming growth factor β (TGFβ) promotes self-renewal and bone morphogenetic protein (BMP) induces differentiation of GSCs. BMP7 induces the transcription factor Snail to promote astrocytic differentiation in GSCs and suppress tumor growth in vivo. We demonstrate that Snail represses stemness in GSCs. Snail interacts with SMAD signaling mediators, generates a positive feedback loop of BMP signaling and transcriptionally represses the TGFB1 gene, decreasing TGFβ1 signaling activity...
February 16, 2018: Oncogene
Hannah Spierson, Yasser Masood, Ross J Craigie, Ngozi Edi-Osagie
No abstract text is available yet for this article.
February 15, 2018: Archives of Disease in Childhood
Wei Zhu, Haitao Cui, Benchaa Boualam, Fahed Masood, Erin Flynn, Raj Rao, Zhiyong Zhang, Lijie Grace Zhang
Cartilage tissue is prone to degradation and has little capacity for self-healing due to its avascularity. Tissue engineering, which provides artificial scaffolds to repair injured tissues, is a novel and promising strategy for cartilage repair. 3D bioprinting offers even greater potential for repairing degenerative tissue by simultaneously integrating living cells, biomaterials, and biological cues to provide a customized scaffold. With regard to cell selection, mesenchymal stem cells (MSCs) hold great capacity for differentiating into a variety of cell types, including chondrocytes, and could therefore be utilized as a cartilage cell source in 3D bioprinting...
February 15, 2018: Nanotechnology
Muhammad Shahid, Muhammad Sohail Akram, Muhammad Asaf Khan, Muhammad Zubair, Shahid Masood Shah, Muhammad Ismail, Ghulam Shabir, Saadia Basheer, Kashif Aslam, Mohsin Tariq
AIMS: The study was planned to characterize Planomicrobium sp. MSSA-10 for plant-beneficial traits and to evaluate its inoculation impact on physiology of pea plants under different salinity levels. METHODS AND RESULTS: Strain MSSA-10 was isolated from pea rhizosphere and identified by the analysis of 16S rRNA gene sequence. The strain demonstrated phosphate solubilization and auxin production up to 2 mol l -1 NaCl and exhibited 1-aminocyclopropane-1-carboxylic acid deaminase activity up to 1...
February 14, 2018: Journal of Applied Microbiology
Sayed-Hamidreza Mozhgani, Seyed Amir Malekpour, Mehdi Norouzi, Fatemeh Ramezani, Seyed Abdolrahim Rezaee, Vahdat Poortahmasebi, Mehdi Sadeghi, Seyed Moayed Alavian, Mohadeseh Zarei-Ghobadi, Azam Ghaziasadi, Hadi Karimzadeh, Reza Malekzadeh, Masood Ziaee, Farshid Abedi, Behrooz Ataei, Majid Yaran, Babak Sayad, Hamid Reza Jahantigh, Mohammad Hossein Somi, Gholamreza Sarizadeh, Ismail Sanei-Moghaddam, Fariborz Mansour-Ghanaei, Hossein Keyvani, Ebrahim Kalantari, Zahra Fakhari, Babak Geravand, Seyed Mohammad Jazayeri
Previous local and national Iranian publications indicate that all Iranian hepatitis B virus (HBV) strains belong to HBV genotype D. The aim of this study was to analyze the evolutionary history of HBV infection in Iran for the first time, based on an intensive phylodynamic study. The evolutionary parameters, time to most recent common ancestor (tMRCA), and the population dynamics of infections were investigated using the Bayesian Monte Carlo Markov chain (BMCMC). The effective sample size (ESS) and sampling convergence were then monitored...
February 13, 2018: Archives of Virology
Saima Shakil Malik, Rakshanda Batool, Nosheen Masood, Azra Yasmin
Prostate cancer is the third most commonly diagnosed cancer among Pakistani men. It is a multifactorial disease involving genetics together with environmental factors. Countries where men have greater dietary fat intake showed increased prostate cancer mortality rates. A population based case-control study was conducted to evaluate various prostate cancer risk factors. Study subjects were 896 prostate cancer cases (2010-2015) and 900 age matched controls. Odds ratio (OR) and 95% CI were used to estimate the association between different risk factors and prostate cancer...
February 9, 2018: Current Problems in Cancer
Ryan M Surmaitis, Muhammad Masood Khalid, David Vearrier, Michael I Greenberg
No abstract text is available yet for this article.
February 12, 2018: Clinical Toxicology
Kalpana Singh, Shivani A Patel, Suddhendu Biswas, Roopa Shivashankar, Dimple Kondal, Vamadevan S Ajay, Ranjit Mohan Anjana, Zafar Fatmi, Mohammed K Ali, M Masood Kadir, Viswanathan Mohan, Nikhil Tandon, K M Venkat Narayan, Dorairaj Prabhakaran
Background: We report the prevalence, risk factors and mortality associated with multimorbidity in urban South Asian adults. Methods: Hypertension, diabetes, heart disease, stroke and chronic kidney disease were measured at baseline in a sample of 16 287 adults ages ≥20 years in Delhi, Chennai and Karachi in 2010-11 followed for an average of 38 months. Multimorbidity was defined as having ≥2 chronic conditions at baseline. We identified correlates of multimorbidity at baseline using multinomial logistic models, and we assessed the prospective association between multimorbidity and mortality using Cox proportional hazards models...
February 7, 2018: Journal of Public Health
Adrian Rhudd, Masood Moghul, Gareth Reid
One of the most common differentials for the acute scrotum is an epididymo-orchitis (EO), which can mimic the presentation of testicular torsion. We present a case of a 37-year-old man presented to the Emergency department with a 3-day history of progressive left testicular pain. A Doppler ultrasound was done which revealed increased flow to the left testicle with no evidence of testicular torsion and he was discharged. He was re-admitted with worsening pain and a repeat scan showed that the penile arterial diastolic flow had reversed, indicating testicular infarction...
October 2017: Journal of Surgical Case Reports
Alireza Jalali, Ebrahim Nasiri, Mohsen Khoramian, Masood Saghafinia, Hasan Siamian
Introduction: Laryngoscopy and tracheal intubation are known to increase sympathetic activity that may be detrimental to patients with preexisting ischaemic or hypertensive heart disease. Aim: The aim of this study was to compare of intravenous and oropharyngeal spray of lidocaine and high dose of fentanyl on systolic and diastolic blood pressures and heart rate of patients over 65 years during tracheal intubation. Material and Methods: In this clinical trial, 160 patients over 65 yrs who were randomly divided into five groups of 32 patients...
December 2017: Medical Archives
Amir H Sohail, Muhammad A A Maan, Muhammad S Khan, Qamar Masood
Background: The ligamenta flava can undergo ossification and calcification resulting in myelopathy. Only seven cases of ligamentum flavum ossification in association with hypoparathyroidism have been reported, most of which had concurrent osseous changes in other spinal ligaments. Here, we report a patient with hypoparathyroidism who presented with ligamentum flavum ossification causing both cervical and thoracic myelopathy. Case Description: A 43-year-old male presented with backache, urinary retention, and lower limb weakness for the last few days...
2018: Surgical Neurology International
Cedric Manlhiot, Sunita O'Shea, Bailey Bernknopf, Michael LaBelle, Nita Chahal, Rejane F Dillenburg, Lillian S Lai, Dirk Bock, Brendan Lew, Sameer Masood, Mathew Mathew, Brian W McCrindle
BACKGROUND: We have previously documented an increase in the incidence of Kawasaki disease (KD) in Ontario followed by a stabilization from 1995 to 2006. We sought to validate the estimation of incidence of KD using administrative data and to describe the epidemiology of KD across Canada from 2004 to 2014. METHODS: We queried the Canadian Hospital Discharge Database for hospital admissions associated with a discharge diagnosis of KD. The data set was manually curated and estimates of incidence were compared with those obtained from the retrospective triennial surveillances of KD performed in 2007 and 2010...
December 15, 2017: Canadian Journal of Cardiology
Amber Siddiqui, Anum S Siddiqui, Masood Jawaid, Kamran Ali Zaman
Objectives Treatment adherence is crucial to the success of a management plan. The objectives of this study are (i) to assess medication adherence in patients with chronic diseases, (ii) to assess if physicians correctly perceive medication adherence among said patients, and (iii) to investigate the factors associated with low drug adherence. Materials & methods This observational cross-sectional study included 283 patients and 208 physicians from various hospitals in Karachi, Pakistan. The participants in the "patient group" completed the eight-item Morisky Medication Adherence Scale form...
November 29, 2017: Curēus
Lara Kujtan, Varsha Muthukumar, Kevin F Kennedy, John Russell Davis, Ashiq Masood, Janakiraman Subramanian
INTRODUCTION: The optimal treatment strategy for resected stage I large cell neuroendocrine carcinoma of the lung (LCNEC) remains unknown. In this analysis, we evaluate the impact of systemic chemotherapy on patients with stage I LCNEC who have undergone surgical resection. METHODS: The study population included patients who underwent surgical resection for LCNEC and had pathologic stage I disease. We compared overall survival between patients who underwent surgical resection alone, and those who underwent surgical resection plus chemotherapy...
January 29, 2018: Journal of Thoracic Oncology
Daphne Lagrou, Rony Zachariah, Karen Bissell, Catherine Van Overloop, Masood Nasim, Hamsaya Nikyar Wagma, Shafiqa Kakar, Séverine Caluwaerts, Eva De Plecker, Renzo Fricke, Rafael Van den Bergh
Background: Provision of Emergency Obstetric and Neonatal Care (EmONC) reduces maternal mortality and should include three components: Basic Emergency Obstetric and Neonatal Care (BEmONC) offered at primary care level, Comprehensive EmONC (CEmONC) at secondary level and a good referral system in-between. In a conflict-affected province of Afghanistan (Khost), we assessed the performance of an Médecins Sans Frontières (MSF) run CEmONC hospital without a primary care and referral system...
2018: Conflict and Health
Almadani A, Dixit S, Rowland-Hill C, Achawal S, Rajaraman Cr, Gerry Go, R Highley, Hussain Masood, Baker L, Gill L, Morris H, Hingorani M
The management of elderly patients with glioblastoma-multiforme (GBM) remains poorly defined with many experts advocating best supportive care in view of limited evidence on efficacy of more aggressive treatment protocols. There is randomised evidence (NORDIC and NA-O8 studies) to support the use of surgery followed by adjuvant monotherapy with either radiotherapy (RT) using hypo-fractionated regimes (e.g. 36 Gy in 6 fractions OR 40 Gy in 15 fractions) or chemotherapy with temozolomide (TMZ) in patients expressing methylation of promoter for O6-methylguanine-DNA methyltransferase (MGMT) enzyme...
January 29, 2018: British Journal of Radiology
Seyed Kazem Mirinezhad, Farideh Mousavi, Masood Baghri, Bita Sepehri, Ali Ghavidel, Morteza Ghojazadeh, Mohammad Hossein Somi
Objective: Familial adenomatous polyposis (FAP), an autosomal dominant inherited disorder is characterized by the presence of multiple adenomatous colorectal polyps, which can develop into cancer during early adulthood. Therefore, early diagnosis is essential. Most FAP patients have several extracolonic manifestations, including congenital hypertrophy of the retinal pigment epithelium (CHRPE). Whereas genetic markers may provide the main route to detection of ‘‘at risk’’ subjects , at present this approach is clearly limited and searches for a noninvasive phenotypic marker continue to be high priority...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Rashid Jooma, Mir Shabbar Ali, Masood Ali Shaikh
Road Traffic Crash (RTC) mortality and morbidity is one of the major public health problems in Karachi. In this study we used geographic information systems (GIS) to visualize and quantify the spatial distribution of RTC mortality and yearly trend from 2008 to 2012, for all 24 administrative subdivisions of Karachi, using Road Traffic Injury Research and Prevention Center's (RTIRPC) data. Cumulatively, 6040 deaths were recorded by RTIRPC, out of which we were able to map 4657 (77.1%) deaths based on location information available in the database...
January 2018: JPMA. the Journal of the Pakistan Medical Association
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