Natalia Rakova, Kathrin Jüttner, Anke Dahlmann, Agnes Schröder, Peter Linz, Christoph Kopp, Manfred Rauh, Ulrike Goller, Luis Beck, Alexander Agureev, Galina Vassilieva, Liubov Lenkova, Bernd Johannes, Peter Wabel, Ulrich Moissl, Jörg Vienken, Rupert Gerzer, Kai-Uwe Eckardt, Dominik N Müller, Karl Kirsch, Boris Morukov, Friedrich C Luft, Jens Titze
The steady-state concept of Na(+) homeostasis, based on short-term investigations of responses to high salt intake, maintains that dietary Na(+) is rapidly eliminated into urine, thereby achieving constant total-body Na(+) and water content. We introduced the reverse experimental approach by fixing salt intake of men participating in space flight simulations at 12 g, 9 g, and 6 g/day for months and tested for the predicted constancy in urinary excretion and total-body Na(+) content. At constant salt intake, daily Na(+) excretion exhibited aldosterone-dependent, weekly (circaseptan) rhythms, resulting in periodic Na(+) storage...
January 8, 2013: Cell Metabolism