Anapatricia García, Nagadenahalli B Siddappa, Qingsheng Li, Ashley T Haase, Katherine Paul, Fawn Stroud, Xiaodong Zhang, Jack A Fountain, François Villinger, Francis J Novembre, James G Else, W Evan Secor, Ruth M Ruprecht
A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4(+) T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV...
October 2010: Journal of Medical Primatology