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Ankylosing spondyloarthritis

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https://www.readbyqxmd.com/read/29148402/incidence-and-prevalence-of-axial-spondyloarthritis-methodologic-challenges-and-gaps-in-the-literature
#1
Rhonda Bohn, Maureen Cooney, Atul Deodhar, Jeffrey R Curtis, Amanda Golembesky
OBJECTIVES: The incidence and prevalence of axial spondyloarthritis (axSpA), including ankylosing spondylitis (AS) and non-radiographic (nr-)axSpA, have been investigated in multiple populations, though there is a paucity of population-level data. Here, we identify population-based studies in AS and nr-axSpA, and describe the methodologic challenges in conducting these, outlining potential reasons for disparate incidence and prevalence estimates. METHODS: PubMed and Embase were searched for population-based studies providing incidence and prevalence rates, published in English from 1 Jan 2000-30 Jun 2015...
November 14, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29142035/the-sex-influence-on-response-to-tumor-necrosis-factor-%C3%AE-inhibitors-and-remission-in-axial-spondyloarthritis
#2
Ennio Lubrano, Fabio Massimo Perrotta, Maria Manara, Salvatore D'Angelo, Olga Addimanda, Roberta Ramonda, Leonardo Punzi, Ignazio Olivieri, Carlo Salvarani, Antonio Marchesoni
OBJECTIVE: The aim of this study was to evaluate the influence of sex on response to treatment and disease remission in patients with axial spondyloarthritis (axSpA). METHODS: In this retrospective multicenter study, patients with axSpA, according to the Assessment of Spondyloarthritis international Society (ASAS) criteria for axSpA, and treated with adalimumab, etanercept, golimumab, or infliximab, were studied. We compared clinical characteristics, patient-reported outcomes, disease activity, function, and response to treatment in male and female patients with this disease...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29142031/activity-limitations-in-patients-with-axial-spondyloarthritis-a-role-for-fear-of-movement-and-re-injury-beliefs
#3
Thijs W Swinnen, Johan W S Vlaeyen, Wim Dankaerts, Rene Westhovens, Kurt de Vlam
OBJECTIVE: To determine whether fear of movement and (re)injury [FOM/(R)I] beliefs, measured with the Tampa Scale for Kinesiophobia 11-item version (TSK-11), influence activity limitations and mediate the relationship between pain severity and activity limitations in axial spondyloarthritis (axSpA). METHODS: In 173 patients with axSpA, these data were collected: sex, body mass index, disease duration, medication, activity limitations (BASFI; Bath Ankylosing Spondylitis Functional Index), disease activity [Bath Ankylosing Spondylitis Disease Activity Index (BASDAI); BASDAIinf, items 5 and 6; BASDAIpain, items 2 and 3; C-reactive protein and physician's global assessment], spinal mobility (BASMI; Bath Ankylosing Spondylitis Metrology Index), and FOM/(R)I (TSK-11)...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29127910/evaluation-of-the-efficacy-and-safety-of-%C3%AE-d-mannuronic-acid-in-patients-with-ankylosing-spondylitis-a-12-week-randomized-placebo-controlled-phase-i-ii-clinical-trial
#4
Mohammad Javad Fattahi, Ahmad Reza Jamshidi, Mahdi Mahmoudi, Mahdi Vojdanian, Mir Saeed Yekaninejad, Fahimeh Jafarnezhad-Ansariha, Hossein Ahmadi, Bernd H A Rehm, Hidenori Matsuo, Salvatore Cuzzocrea, Mostafa Hosseini, Seyed Naser Hashemi, Zahra Aghazadeh, Abbas Mirshafiey
OBJECTIVE: To evaluate the efficacy, safety and tolerability of β-d-mannuronic acid (M2000) in the treatment of ankylosing spondylitis (AS). METHODS: The study was a 12-week randomized, double-blind, placebo-controlled, phase I/II clinical trial with 3 treatment arms: placebo, β-d-mannuronic acid and naproxen. Patients who had AS according to the modified New York criteria, with active disease at baseline were eligible for study. Primary outcome measure was the Assessment of SpondyloArthritis international Society (ASAS) 20 response rate at week 12...
November 8, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29093622/adalimumab-efficacy-in-enteropathic-spondyloarthritis-a-12-mo-observational-multidisciplinary-study
#5
Michele Maria Luchetti, Devis Benfaremo, Francesco Ciccia, Laura Bolognini, Monia Ciferri, Alessia Farinelli, Matteo Rossini, Piergiorgio Mosca, Giovanni Triolo, Armando Gabrielli
AIM: To report adalimumab (Ada) efficacy on articular-gastrointestinal disease and health-related quality of life (HRQoL) in patients with enteropathic spondyloarthritis (ES). METHODS: A cohort of 52 patients with ES was evaluated in the departments of gastroenterology and internal medicine. At baseline, all patients underwent assessment by an integrated gastro-rheumatologic evaluation of articular and gastrointestinal activity, as well patient reported outcomes (PROs) of the HRQoL questionnaires...
October 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29090349/bone-disease-in-axial-spondyloarthritis
#6
REVIEW
Margot Van Mechelen, Giulia Rossana Gulino, Kurt de Vlam, Rik Lories
Axial spondyloarthritis is a chronic inflammatory skeletal disorder with an important burden of disease, affecting the spine and sacroiliac joints and typically presenting in young adults. Ankylosing spondylitis, diagnosed by the presence of structural changes to the skeleton, is the prototype of this disease group. Bone disease in axial spondyloarthritis is a complex phenomenon with the coexistence of bone loss and new bone formation, both contributing to the morbidity of the disease, in addition to pain caused by inflammation...
October 31, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29075521/imaging-of-juvenile-spondyloarthritis-part-i-classifications-and-radiographs
#7
REVIEW
Iwona Sudoł-Szopińska, Piotr Gietka, Michał Znajdek, Genowefa Matuszewska, Magdalena Bogucevska, Ljubinka Damjanovska-Krstikj, Slavcho Ivanoski
Juvenile spondyloarthropathies are manifested mainly by symptoms of peripheral arthritis and enthesitis. By contrast with adults, children rarely present with sacroiliitis and spondylitis. Imaging and laboratory tests allow early diagnosis and treatment. Conventional radiographs visualize late inflammatory lesions and post-inflammatory complications. Early diagnosis is possible with the use of ultrasonography and magnetic resonance imaging. The first part of the article presents classifications of juvenile spondyloarthropathies and discusses their radiographic presentation...
September 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/29074297/hierarchical-imbalanced-pro-inflammatory-cytokine-networks-govern-the-pathogenesis-of-chronic-arthropathies
#8
REVIEW
G Livshits, A Kalinkovich
BACKGROUND: Chronic inflammatory arthropathies, such as rheumatoid arthritis (RA), spondyloarthritis, including psoriatic arthritis (PsA), ankylosing spondyloarthritis (AS), osteoarthritis (OA), and intervertebral disc degenerative disease (DDD) constitute major public health problems that are anticipated to grow significantly as the human population ages. However, many aspects concerning the molecular mechanisms underlying their onset and progression remain unclear. DESIGN: This narrative review critically analyzes the molecular mechanisms underlying the inflammation-associated pathogenesis of the aforementioned joint diseases...
October 24, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29071119/switching-biological-disease-modifying-antirheumatic-drugs-in-patients-with-axial-spondyloarthritis-results-from-a-systematic-literature-review
#9
Victoria Navarro-Compán, Chamaida Plasencia-Rodríguez, Eugenio de Miguel, Petra Diaz Del Campo, Alejandro Balsa, Jordi Gratacós
OBJECTIVES: First, to investigate if switching biological disease-modifying antirheumatic drugs (bDMARDs) after the failure to prior bDMARD is efficacious in patients with axial spondyloarthritis (axSpA). Second, to evaluate the influence on this efficacy of (1) the reason to discontinue prior tumour necrosis factor inhibitor (TNFi), (2) changing the type of TNFi and (3) changing the target. METHODS: A systematic literature review until January 2017 was performed using Medline, EMBASE and Cochrane databases...
2017: RMD Open
https://www.readbyqxmd.com/read/29065931/relevance-of-structural-damage-in-the-sacroiliac-joints-for-the-functional-status-and-spinal-mobility-in-patients-with-axial-spondyloarthritis-results-from-the-german-spondyloarthritis-inception-cohort
#10
Mikhail Protopopov, Joachim Sieper, Hildrun Haibel, Joachim Listing, Martin Rudwaleit, Denis Poddubnyy
BACKGROUND: Functional status and spinal mobility in patients with axial spondyloarthritis (axSpA) are known to be determined both by disease activity and by structural damage in the spine. The impact of structural damage in the sacroiliac joints (SIJ) on physical function and spinal mobility in axSpA has not been studied so far. The objective of the study was to analyze the impact of radiographic sacroiliitis on functional status and spinal mobility in patients with axSpA. METHODS: In total, 210 patients with axSpA were included in the analysis...
October 24, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29042938/risk-of-infection-in-patients-with-spondyloarthritis-and-ankylosing-spondylitis-receiving-antitumor-necrosis-factor-therapy-a-meta-analysis-of-randomized-controlled-trials
#11
Zhigao Xu, Peipei Xu, Wei Fan, Gui Yang, June Wang, Qingyuan Cheng, Mingxia Yu
Antitumor necrosis factor (TNF) agents have been widely used for the treatment of spondyloarthritis (SpA) and ankylosing spondylitis (AS). However, these agents may increase the risk of infection due to suppressing the immune response. The present meta-analysis was performed to systematically investigate the risk of overall infection, serious infection and tuberculosis in patients with SpA and AS treated with anti-TNF agents. Medline, Embase and the Cochrane library were searched for randomized controlled trials (RCTs) published between January 1998 and December 2015 about infection in patients with SpA receiving anti-TNF therapy...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29038299/an-assessment-in-spondyloarthritis-international-society-asas-endorsed-definition-of-clinically-important-worsening-in-axial-spondyloarthritis-based-on-asdas
#12
Anna Molto, Laure Gossec, Bhowmik Meghnathi, Robert B M Landewé, Désirée van der Heijde, Pamir Atagunduz, Bassel Kamal Elzorkany, Nurullah Akkoc, Uta Kiltz, Jieruo Gu, James Cheng Chung Wei, Maxime Dougados
INTRODUCTION: In a previous phase, 12 draft definitions for clinically important worsening in axial spondyloarthritis (axSpA) were selected, of which 3 were based on absolute changes in Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP (ASDAS). The objective here was to select the best cut-off for ASDAS for clinically important worsening in axSpA for use in clinical trials and observational studies. METHODS: An international longitudinal prospective study evaluating stable patients with axSpA was conducted...
October 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29026327/characterization-and-prevalence-of-spondyloarthritis-and-peripheral-arthritis-among-patients-with-inflammatory-bowel-disease
#13
Hoda M Malaty, Grace Hsiao-Wei Lo, Jason K Hou
BACKGROUND: Joint complaints such as spondyloarthritis and peripheral arthritis are the most common extraintestinal manifestations in patients with inflammatory bowel disease (IBD); however, the evaluation of these symptoms are poorly described. OBJECTIVES: To examine the clinical characteristics and prevalence of ankylosing spondylitis (AS) and other joint complaints among patients with IBD. METHODS: In a local cohort of patients diagnosed with IBD between 1996 and 2009, we performed a retrospective study at the Veterans Affairs Hospital...
2017: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29019640/spine-conditions-mechanical-and-inflammatory-low-back-pain
#14
Christopher Ledford
Mechanical low back pain (LBP) is an injury or derangement of an anatomic structure in the low back. When evaluating patients with LBP, clinicians should maintain clinical suspicion for vertebral fracture, cancer, and cauda equina syndrome. Management includes patient education focused on exercise, massage, and behavioral approaches such as cognitive behavioral therapy. Acupuncture can be an effective alternative and specific herbal supplements may provide short-term pain relief. The prognosis for patients with mechanical LBP is good...
October 2017: FP Essentials
https://www.readbyqxmd.com/read/28980904/optimal-concentration-range-of-golimumab-in-patients-with-axial-spondyloarthritis
#15
Ana Martínez-Feito, Chamaida Plasencia-Rodriguez, Victoria Navarro-Compán, Teresa Jurado, Eva Linda Kneepkens, Gertjan J Wolbink, Sergio Martín, Ainhoa Ruiz Del Agua, Rosaura Navarro, Araceli Mezcua, Andrea Jochems, Diana Peiteado, Maria Gema Bonilla, Alejandro Balsa, Dora Pascual-Salcedo
OBJECTIVES: To investigate the association between serum golimumab (GLM) trough levels, clinical disease activity and treatment response during the first year of therapy in patients with axial spondyloarthritis (axSpA), as well as determining an optimal concentration range of GLM in axSpA. METHODS: This was an observational prospective study including 49 patients with axSpA monitored during 52 weeks (W52). Serum GLM trough levels were measured by capture ELISA and antidrug antibodies by bridging ELISA at baseline, W24 and W52...
September 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28968836/limited-reliability-of-radiographic-assessment-of-spinal-progression-in-ankylosing-spondylitis
#16
Sibel Zehra Aydin, Esen Kasapoglu Gunal, Esra Kurum, Servet Akar, Halit Eyyup Mungan, Fatma Alibaz-Oner, Robert G Lambert, Pamir Atagunduz, Helena Marzo Ortega, Dennis McGonagle, Walter P Maksymowych
Objectives: Conventional radiography is key to assessing AS-related spinal involvement and has become increasingly important given that spinal fusion may continue under biologic therapy. We aimed to compare the reliability of radiographic scoring of the spine by using different approaches to understand how different readers agree on overall scores and on individual findings. Method: Six investigators scored 68 plain radiographs of the cervical and lumbar spine of 34 patients with a 2-year interval, for erosions, sclerosis, squaring, syndesmophytes and ankyloses using the Spondyloarthritis Radiography (SPAR) module...
September 15, 2017: Rheumatology
https://www.readbyqxmd.com/read/28967358/causes-of-pain-in-patients-with-axial-spondyloarthritis
#17
REVIEW
Uta Kiltz, Xenofon Baraliakos, Andrea Regel, Bjoern Bühring, Juergen Braun
Back pain, most frequently of the inflammatory type, is the leading symptom in patients with axial spondyloarthritis (axSpA). Back pain in these patients is usually either due to axial inflammation or structural changes based on new bone formation. However, there are other possible causes of pain in these patients. There is, for example, a strongly increased risk of vertebral fractures, and, especially in patients with longstanding disease, degenerative spinal changes may play an additional role as a cause of pain...
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28961700/ankylosing-spondylitis-and-axial-spondyloarthritis-in-patients-with-long-term-inflammatory-bowel-disease-results-from-20-years-of-follow-up-in-the-ibsen-study
#18
Alvilde M Ossum, Øyvind Palm, Aida Kapic Lunder, Milada Cvancarova, Hasan Banitalebi, Anne Negård, Ole Høie, Magne Henriksen, Bjørn A Moum, Marte Lie Høivik
Background: Patients with inflammatory bowel disease (IBD) often suffer from rheumatic manifestations, including inflammatory back disorders. The prevalence of these disorders late in the course of IBD is poorly investigated. The aim of this study was to estimate the prevalence of inflammatory back disorders in patients with IBD 20 years after diagnosis and to investigate possible associations with IBD severity, HLA-B27 and the NOD2 genotype. Methods: A population-based cohort (the IBSEN study) was followed prospectively for 20 years...
September 13, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28955496/relationships-between-ultrasound-enthesitis-disease-activity-and-axial-radiographic-structural-changes-in-patients-with-early-spondyloarthritis-data-from-desir-cohort
#19
Adeline Ruyssen-Witrand, Bénédicte Jamard, Alain Cantagrel, Delphine Nigon, Damien Loeuille, Yannick Degboe, Arnaud Constantin
BACKGROUND: To search for association between ultrasound (US) enthesis abnormalities and disease activity, spine and sacro-iliac joints (SIJ) MRI inflammatory lesions and spine structural changes in a cohort of patients suspected for axial spondyloarthritis (SpA). METHODS: Patients: Of 708 patients included in the DESIR(Devenir des Spondyloarthrites Indifférenciées Récentes) cohort, 402 had an US enthesis assessment and were selected for this study. Imaging: Achilles, lateral epicondyles, superior patellar ligament, inferior patellar ligament entheses were systematically US scanned and abnormalities were summed in US structural and power Doppler (PDUS) scores...
2017: RMD Open
https://www.readbyqxmd.com/read/28943073/the-reliability-and-validity-of-a-venezuelan-version-of-the-bath-ankylosing-spondylitis-functional-index-basfi-and-bath-ankylosing-spondylitis-disease-activity-index-basdai
#20
Mayra Rauseo Vera, Luis Arturo Gutiérrez-González, Irama Maldonado, Soham Al Snih
INTRODUCTION: Spondyloarthropathies (SpA) are disabling diseases with a prevalence of 1.9% in the general population. The indices designed for monitoring the disease should be valid, reliable and cross-culturally adapted for decision-making concerning the appropriate treatment. Changing an adjective or pronoun in a self-administered questionnaire could be the big difference in condensing an idea in a few words and transmitting that concept to all those who share the same language. OBJECTIVES: To develop a Venezuelan version of the original English version of the BASDAI/BASFI and to evaluate its reliability and validity in Venezuelan patients with SpA...
September 21, 2017: Reumatología Clinica
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