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https://www.readbyqxmd.com/read/29238510/epidemiology-transmission-diagnosis-and-outcome-of-hepatitis-c-virus-infection
#1
REVIEW
Seyed Hamid Moosavy, Parivash Davoodian, Mirza Ali Nazarnezhad, Abdolazim Nejatizaheh, Ebrahim Eftekhar, Hamidreza Mahboobi
Hepatitis C infection is one of the main causes of chronic liver disorders worldwide. Nearly three percent (3%) of the world population has an HCV infection. Prevalence of HCV infection was higher in some groups such as injected drug users (IDUs) and HIV positive populations. Acute hepatitis has proven asymptomatic in most cases, and delay of diagnosis might lead to late onset of hepatocellular carcinoma and cirrhosis. Some host characteristics such as age, gender, body mass index, and viral properties are associated with HCV outcome hepatitis...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29235266/host-genetic-variations-associated-with-disease-progression-in-chronic-hepatitis-c-virus-infection
#2
REVIEW
Kentaro Matsuura, Yasuhito Tanaka
Treatment with recently-developed interferon-free oral regimens combining direct-acting antiviral agents (DAAs) results in the elimination of hepatitis C virus (HCV) in almost all chronic hepatitis C (CHC) patients. In the era of DAAs, surveillance of hepatocellular carcinoma (HCC) after eradication of HCV by anti-HCV therapy is particularly important. As is well known, an advanced state of hepatic fibrosis is the major risk factor for developing HCC. Therefore, an increased understanding of various factors associated with disease progression and development of HCC in CHC patients is essential for implementing personalized treatment and surveillance of disease progression and HCC...
December 13, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29234639/hepatocellular-carcinoma-with-macrovascular-invasion-defining-the-optimal-treatment-strategy
#3
REVIEW
Charlotte E Costentin, Cristina R Ferrone, Ronald S Arellano, Suvranu Ganguli, Theodore S Hong, Andrew X Zhu
Background: Tumoral macrovascular invasion (MVI) of hepatic and/or portal vein branches is a common phenomenon in hepatocellular carcinoma (HCC) and is associated with poorer prognosis when compared to HCC without MVI. Summary: Current international guidelines for the management of HCC recommend sorafenib as the only treatment option in case of MVI. Despite guideline recommendations, several alternative options have been tested to manage HCC with MVI: surgery, transarterial chemoembolization, external or internal radiation, hepatic arterial infusion chemotherapy, percutaneous treatment, cryotherapy, or the combination of two or more of these strategies, with or without sorafenib...
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234638/prospective-comparison-of-gd-eob-dtpa-enhanced-mri-with-dynamic-ct-for-detecting-recurrence-of-hcc-after-radiofrequency-ablation
#4
Yasuharu Imai, Kazuhiro Katayama, Masatoshi Hori, Takayuki Yakushijin, Kenji Fujimoto, Toshifumi Itoh, Takumi Igura, Mitsuru Sakakibara, Manabu Takamura, Masakatsu Tsurusaki, Hiroto Takahashi, Katsuyuki Nakanishi, Noriaki Usuki, Koh Tsuji, Hiroshi Ohashi, Tonsok Kim, Tetsuo Takehara, Takamichi Murakami
Background: We prospectively compared the efficacy of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) with that of dynamic multidetector computed tomography (MDCT) for detection of recurrent hypervascular hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). Methods: Institutional review board approval and written informed consent were obtained for this multicenter study. Ninety-seven HCC patients treated with curative RFA underwent both Gd-EOB-DTPA-enhanced MRI and dynamic MDCT every 3-4 months...
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234631/sorafenib-versus-hepatic-arterial-infusion-chemotherapy-as-initial-treatment-for-hepatocellular-carcinoma-with-advanced-portal-vein-tumor-thrombosis
#5
Michihisa Moriguchi, Takeshi Aramaki, Hideyuki Nishiofuku, Rui Sato, Koiku Asakura, Kanji Yamaguchi, Toshihiro Tanaka, Masahiro Endo, Yoshito Itoh
Objective: To investigate the validity of hepatic arterial infusion chemotherapy with low-dose 5-fluorouracil and cisplatin (LFP) versus sorafenib as first-line treatment for hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (Vp3, Vp4). Patients and Methods: We retrospectively reviewed the cases of Child-Pugh A advanced HCC with Vp3 or Vp4 treated with LFP or sorafenib between October 2002 and December 2013. Results: There were 32 patients in the LFP group and 14 patients in the sorafenib group...
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29233685/contrast-enhanced-ultrasound-in-mixed-hepatocellular-cholangiocarcinoma-case-series-and-review-of-the-literature
#6
Yi Dong, Andreas Teufel, Jörg Trojan, Annalisa Berzigotti, Xin Wu Cui, Christoph F Dietrich
BACKGROUND: Mixed hepatocellular cholangiocarcinoma is a rare form of primary liver cancer. AIMS: The aim of this study is to report the results of the use of contrast enhanced ultrasound in a series of patients with confirmed mixed hepatocellular cholangiocarcinoma and to provide an updated literature review. METHODS: Between January 2012 and October 2016, 25 Asian patients with confirmed mixed hepatocellular cholangiocarcinoma were included in this bicentric retrospective analysis...
November 24, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29233562/comparison-of-radiation-therapy-modalities-for-hepatocellular-carcinoma-with-portal-vein-thrombosis-a-meta-analysis-and-systematic-review
#7
Chai Hong Rim, Chul Yong Kim, Dae Sik Yang, Won Sup Yoon
PURPOSE: We performed a meta-analysis and systematic review to compare the radiotherapy (RT) modalities for hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT). MATERIALS AND METHODS: We searched the PubMed, EMBASE, Medline, and Cochrane library databases. The primary endpoint was the 1-year overall survival (OS), and response rate (RR), local control (LC), 2-year OS, and grade ≥3 toxicity incidence were evaluated as secondary endpoints. RESULTS: Thirty-seven studies comprising 2513 patients were included...
December 9, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29232529/arantius-ligament-suspension-a-novel-technique-for-retraction-of-the-left-lateral-lobe-liver-during-laparoscopic-isolated-caudate-lobectomy
#8
Songshan Chai, Jianping Zhao, Yuxin Zhang, Shuai Xiang, Wanguang Zhang
BACKGROUND: Laparoscopic isolated caudate lobectomy remains a challenging procedure because of its deep location and proximity to the important vessels. We present a novel technique, Arantius ligament suspension, which could improve operative field exposure in laparoscopic isolated caudate lobectomy through retraction of the left lateral lobe liver. MATERIALS AND METHODS: The Arantius ligament suspension technique was performed in 6 selected patients during laparoscopic isolated caudate lobectomy in our center: 2 with symptomatic hepatic cavernous hemangioma and 4 with hepatocellular carcinoma (HCC)...
December 12, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29231769/liver-transplantation-beyond-or-downstaging-within-the-milan-criteria-for-hepatocellular-carcinoma
#9
Sean R Rudnick, Mark W Russo
Unresectable hepatocellular carcinoma (HCC) is a common indication for liver transplantation (LT). The Milan criteria became standard criteria but expansion beyond the Milan criteria (tumor size and number) have resulted in similar post-transplant outcomes, thus suggesting LT is a viable treatment option for HCC presenting beyond the Milan criteria Areas covered: Expanded criteria and the use of downstaging therapies to meet Milan criteria are reviewed. Surrogates of tumor biology (including biomarkers and response to therapy) are described in detail...
December 12, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29230556/liver-directed-therapy-for-hepatocellular-carcinoma
#10
Kazim H Narsinh, David P Duncan, Isabel G Newton, Jeet Minocha, Steven C Rose
Liver-directed therapy is a critical component of treatment strategies for hepatocellular carcinoma. These therapies included percutaneous image-guided ablation, transarterial chemoembolization, and transarterial radioembolization, and are administered by interventional radiologists. Depending on the stage of disease, a particular treatment modality, or a combination thereof, is expected to be most efficacious in achieving the goals of treatment for a particular patient. This article seeks to review the various liver-directed treatment modalities for treatment of hepatocellular carcinoma, with attention to their efficacy and patient selection criteria...
December 11, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29230525/diagnostic-accuracy-of-prospective-application-of-the-liver-imaging-reporting-and-data-system-li-rads-in-gadoxetate-enhanced-mri
#11
Yeun-Yoon Kim, Chansik An, Sungwon Kim, Myeong-Jin Kim
OBJECTIVES: To evaluate the diagnostic performance of the LI-RADS (v2014) on gadoxetate-enhanced MRI prospectively applied in actual practice. METHODS: We retrospectively reviewed the prospectively written radiology reports of 143 treatment-naïve at-risk patients who underwent gadoxetate-enhanced liver MRI from January to December 2014, and identified 202 hepatic observations categorized using the LI-RADS. The diagnostic performances of LI-RADS categories for hepatocellular carcinoma (HCC) and hepatic malignancy were calculated...
December 11, 2017: European Radiology
https://www.readbyqxmd.com/read/29228810/systematic-review-and-meta-analysis-of-endostar-combined-with-transcatheter-arterial-chemoembolization-tace-versus-tace-alone-for-hepatocellular-carcinoma
#12
Ya-Qing Zhang, Fei Zhao, Lei Song, Hong-Yun Gan, Xiao-Feng Xie
Many studies have investigated the efficacy of Endostar combined with transcatheter arterial chemoembolization (TACE) versus TACE alone for hepatocellular carcinoma (HCC). A systematic review was conducted to evaluate the efficacy of Endostar. PubMed, Embase, and other databases were searched, and meta-analysis was performed using RevMan 5.3 software. Nine studies, all of which were clinical randomized controlled trials, involving 411 participants were included. The overall response rate, disease control rate and α-fetoprotein negative conversion ratio, and the 6- and 12-month survival rate of HCC patients treated with combined Endostar and TACE were higher than those treated with TACE alone ( P < ...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/29225478/the-utility-of-biomarkers-in-hepatocellular-carcinoma-review-of-urine-based-1h-nmr-studies-what-the-clinician-needs-to-know
#13
REVIEW
Caroline R Cartlidge, M R Abellona U, Alzhraa M A Alkhatib, Simon D Taylor-Robinson
Hepatocellular carcinoma (HCC) is the fifth most common malignancy, the third most common cause of cancer death, and the most common primary liver cancer. Overall, there is a need for more reliable biomarkers for HCC, as those currently available lack sensitivity and specificity. For example, the current gold-standard biomarker, serum alpha-fetoprotein, has a sensitivity of roughly only 70%. Cancer cells have different characteristic metabolic signatures in biofluids, compared to healthy cells; therefore, metabolite analysis in blood or urine should lead to the detection of suitable candidates for the detection of HCC...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/29224329/-allogeneic-hematopoietic-stem-cell-transplantation-for-the-treatment-of-severe-aplastic-anemia-complicated-with-hepatocellular-carcinoma-a-case-report-and-literature-review
#14
S W Yang, Z M Zhu, X L Yuan, L Jiang, R J Ma, Y Zhang
No abstract text is available yet for this article.
November 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29223570/regulation-and-role-of-nuclear-factor-e2-related-factor2-nrf2-in-multidrug-resistance-of-hepatocellular-carcinoma
#15
REVIEW
Bing Tian, Zhen-Ning Lu, Xiu-Li Guo
Hepatocellular carcinoma (HCC) chemoresistance, which is regarded as a kind of stress management reaction to chemotherapy drugs, severely hinders the therapy outcomes of HCC treatment. Stress management is generally achieved by activating certain signal pathways and chemical factors, among which, nuclear factor-E2-related factor2 (Nrf2) is a key factor in HCC chemoresistance formation. Nrf2 is a nuclear factor that coordinates the induction and expression of a battery of genes encoding cytoprotective proteins when participating in the Nrf2antioxidant response element (Nrf2/ARE) pathway, which is one of the most important intracellular antioxidant stress pathways...
December 6, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29220583/elevated-serum-vitamin-b12-levels-as-a-prognostic-factor-for-survival-time-in-metastatic-cancer-patients-a-retrospective-study
#16
Hye Kyung Oh, Jee Young Lee, Wan Kyu Eo, Seong Woo Yoon, Sung Nim Han
BACKGROUND: Serum vitamin B12 levels have been proposed as one of the survival prediction factors, although no survival analysis in metastatic cancer patients has been conducted yet. This study examined whether serum vitamin B12 levels could be a prognostic factor in metastatic cancer patients. METHODS: Data from a retrospective chart review were used to perform Kaplan-Meier and multivariate analyses of the Cox proportional hazards. Subgroup analysis was performed on patients without a liver lesion (hepatocellular carcinoma or liver metastasis)...
December 8, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29218813/association-of-pnpla3-rs738409-polymorphism-with-liver-steatosis-but-not-with-cirrhosis-in-patients-with-hbv-infection-systematic-review-with-meta-analysis
#17
REVIEW
Saman Ghalamkari, Heidar Sharafi, Seyed Moayed Alavian
BACKGROUND AND AIM: Hepatitis B virus (HBV) infection is a worldwide health issue and is well known to be the main cause of developing secondary liver complications such as cirrhosis and hepatocellular carcinoma (HCC). The PNPLA3 rs738409 polymorphism has been investigated conclusively with occurrence risk of steatosis and cirrhosis. Therefore, performing a meta-analysis of the available studies with the aim of clarifying the association between rs738409 and occurrence risk of steatosis and cirrhosis among HBV-infected patients would be helpful...
December 7, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29216833/non-alcoholic-fatty-liver-disease-as-a-risk-factor-for-cholangiocarcinoma-a-systematic-review-and-meta-analysis
#18
Nicha Wongjarupong, Buravej Assavapongpaiboon, Paweena Susantitaphong, Wisit Cheungpasitporn, Sombat Treeprasertsuk, Rungsun Rerknimitr, Roongruedee Chaiteerakij
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has been recently identified as a risk factor of gastrointestinal tract cancers, especially hepatocellular carcinoma, and colorectal cancer. Whether NAFLD is a risk factor for cholangiocarcinoma (CCA) remains inconclusive. The aim of this study is to determine a potential association between NAFLD and CCA, stratifying by its subtypes; intrahepatic CCA (iCCA), and extrahepatic CCA (eCCA). METHODS: A search was conducted for relevant studies published up to April 2017 using MEDLINE, EMBASE, Scopus and Cochrane databases...
December 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29212576/the-effects-of-physical-exercise-on-fatty-liver-disease
#19
Dirk J van der Windt, Vikas Sud, Hongji Zhang, Allan Tsung, Hai Huang
The increasing prevalence of obesity has made non-alcoholic fatty liver disease (NAFLD) the most common chronic liver disease. As a consequence, NAFLD and especially its inflammatory form non-alcoholic steatohepatitis (NASH) are the fastest increasing etiology of end-stage liver disease and hepatocellular carcinoma. Physical inactivity is related to the severity of fatty liver disease irrespective of body weight, supporting the hypothesis that increasing physical activity through exercise can improve fatty liver disease...
December 6, 2017: Gene Expression
https://www.readbyqxmd.com/read/29212241/prognostic-group-stratification-and-nomogram-for-predicting-overall-survival-in-patients-who-received-radiotherapy-for-abdominal-lymph-node-metastasis-from-hepatocellular-carcinoma-a-multi-institutional-retrospective-study-krog-15-02
#20
Youngkyong Kim, Hee Chul Park, Sang Min Yoon, Tae Hyun Kim, Jieun Lee, Jinhyun Choi, Jeong Il Yu, Jin-Hong Park, Jong Hoon Kim, Joong-Won Park, Jinsil Seong
Objective: To develop a prognostic model for overall survival (OS) in hepatocellular carcinoma (HCC) patients receiving radiotherapy (RT) to metastatic abdominal lymph nodes (LNs). Materials and Methods: Two hundred twenty-eight patients treated with RT to metastatic abdominal LNs were retrospectively reviewed. Results: Median OS in all patients was 11.1 months. LN responders had significantly higher median OS than non-responders (14.2 months vs...
November 7, 2017: Oncotarget
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