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https://www.readbyqxmd.com/read/29675893/characteristics-of-opioid-maintained-clients-smoking-fentanyl-patches-the-importance-of-confirmatory-drug-analysis-illustrated-by-a-case-series-and-mini-review
#1
Andreas Kimergård, Jacklyn Dunne, Anette Bøgen, Peter Hindersson, Torben Breindahl
The increase in opioid prescribing in many European countries over the last decade has raised concerns about associated diversion, overdose and mortality. Fentanyl is one of these synthetic opioids that is typically prescribed as a transdermal patch for pain that requires continuous pain relief and has been the focus of investigations due to reports of overdose and death. We report a case series of 14 drug addiction treatment entrants who entered treatment in one service located in the region of Southern Denmark from August 2015 to December 2015 for smoking fentanyl patches...
April 19, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29650821/-continuation-of-axitinib-for-advanced-renal-cell-carcinoma-by-the-application-of-homecare-urology-a-case-report-and-literature-review
#2
Satoshi Yazawa, Yuji Kato, Jin Nakahara, Toshio Miyata, Mototsugu Oya
A 56-year-old man with advanced RCC and a past medical history of type 2 diabetes underwent a radical left nephrectomy following a histological diagnosis of papillary RCC, G2, INF b, pT3, V1 in 1999. In 2008, sorafenib was started to treat multiple pulmonary metastases of RCC. In 2011, sorafenib was switched to sunitinib when radiologic progression was observed. In 2014, sunitinib was switched to axitinib when further radiologic progression was observed. In 2015, the patient was referred to Yazawa clinic for homecare urology when hospital visits became difficult due to cancer pain and bilateral lower-extremity muscle weakness...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29578144/transdermal-fentanyl-for-cancer-pain-trial-sequential-analysis-of-3406-patients-from-35-randomized-controlled-trials
#3
Dong-Dong Wang, Ting-Ting Ma, Hua-Dong Zhu, Cong-Bin Peng
Objective: The aim of this study was to assess the effectiveness and safety of transdermal fentanyl for the treatment of moderate or severe cancer-related pain. Materials and Methods: Electronic databases including PubMed, Embase, the Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure, the Chinese Biomedical Literature Database, and Chongqing Weipu and Wanfang Database were searched for relevant studies published prior to January 2015. Only randomized controlled trials on the use of the transdermal fentanyl patch for the treatment of cancer pain were selected...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29516968/clinical-analysis-of-electroacupuncture-and-multiple-acupoint-stimulation-in-relieving-cancer-pain-in-patients-with-advanced-hepatocellular-carcinoma
#4
Lili Xu, Yongxian Wan, Juan Huang, Fangyuan Xu
Objective: The objective of this study is to investigate the clinical efficacy and safety of electroacupuncture and multiple acupoint stimulation in relieving cancer pain in patients with advanced hepatocellular carcinoma. Methods: Sixty-five cases of advanced hepatocellular carcinoma with cancer pain were selected in our hospital and were divided into electroacupuncture multiple acupoint stimulation group (electroacupuncture group) (n = 32) and fentanyl transdermal patch analgesia group (control group) (n = 33) according to analgesic methods and intentions...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29455092/internet-pseudoscience-testing-opioid-containing-formulations-with-tampering-potential
#5
Jennifer P Pascali, Paolo Fais, Fabio Vaiano, Nicola Pigaiani, Stefano D'Errico, Sandra Furlanetto, Diego Palumbo, Elisabetta Bertol
Drug tampering practices, with the aim to increase availability of drug delivery and/or enhance drug effects, are accessible on Internet and are practiced by some portion of recreational drug users. Not rarely, recreational misuse may result in toxic and even fatal results. The aim of the present study was to assess the tampering risk of medicaments containing different formulations of an opioid in combination with paracetamol or dexketoprofen, following the procedures reported in dedicated forums on the web...
February 10, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29409271/comparison-of-postoperative-pain-control-methods-after-bony-surgery-in-the-foot-and-ankle
#6
Chan Kang, Gi-Soo Lee, Sang-Bum Kim, You-Gun Won, Jeong-Kil Lee, You-Sun Jung, Hyung-June Cho
BACKGROUND: We performed a prospective study to evaluate and compare the effectiveness of postoperative pain control methods after bone surgery in the foot and ankle. METHODS: Among the patients who underwent foot and ankle surgery from June 2014 to September 2015 with an ultrasound-guided nerve block, 84 patients who fully completed a postoperative pain survey were enrolled. An opioid patch (fentanyl patch, 25mg) was applied in group A (30 patients). Diluted anesthetic (0...
June 24, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29317930/ontario-patch-for-patch-fentanyl-return-program-6-month-review-of-patient-returns-and-opinions
#7
Ali Chaudhry
No abstract text is available yet for this article.
January 2018: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/29201847/the-efficacy-of-fentanyl-transdermal-patch-as-the-first-line-medicine-for-the-conservative-treatment-of-osteoporotic-compression-fracture
#8
June Ho Choi, Hui Dong Kang, Jin Hoon Park, Bon Sub Gu, Sang Ku Jung, Se Hyun Oh
Objective: There are no strong guidelines on how long or how we should undertake conservative treatment during the acute period of an osteoporotic vertebral compression fracture (VCF). Methods: We treated 202 patients with conservative treatment on VCF from March 2012 to August 2015. On inclusion criteria, 75 patients (22 males and 53 females) were included in the final analysis. After admission, a transdermal fentanyl patch with low dose (12.5 µg) application was attempted in all patients...
October 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29174960/the-uptake-of-transdermal-fentanyl-in-a-pregnant-sheep-model
#9
Gabrielle C Musk, C S Melanie Catanchin, Haruo Usuda, Eleanor Woodward, Matthew W Kemp
OBJECTIVE: To evaluate the maternal and foetal uptake of transdermal fentanyl patch applied to the groin of pregnant sheep following surgery. STUDY DESIGN: Prospective series. ANIMALS: A group of 16 singleton pregnant sheep underwent anaesthesia for laparotomy, hysterotomy and instrumentation of the foetus. Of these ewes 10 (101 ± 12 days of gestation) were used to evaluate the maternal uptake of transdermal fentanyl, and the efficacy of the drug in the postoperative period (n = 10)...
November 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29136228/opioid-prescription-use-in-nursing-home-residents-with-advanced-dementia
#10
Charlotte Griffioen, Bettina S Husebo, Elisabeth Flo, Monique A A Caljouw, Wilco P Achterberg
Background: Although proper pain treatment may require opioids, discussion continues about possible undertreatment or overtreatment in persons with advanced dementia. Objective: To investigate the prevalence of pain, frequency of opioid prescription use, and factors associated with strong opioid prescription use in nursing homes. Design: Cross-sectional study. Setting and Subjects: Eighteen Norwegian nursing homes; 327 persons with advanced dementia and behavioral disturbances participated...
November 9, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29033716/transdermal-fentanyl-as-an-adjuvant-to-paravertebral-block-for-pain-control-after-breast-cancer-surgery-a-randomized-double-blind-controlled-trial
#11
Ahmed H Bakeer, Nasr M Abdallah
OBJECTIVE: The aim of this study is to investigate the effect of transdermal fentanyl (TDF) as an adjuvant to paravertebral block (PVB) for pain control after breast cancer surgery. PATIENTS AND METHODS: This randomized, double-blind trial included fifty females with breast cancer scheduled for surgery. They were randomly allocated into one of two equal groups. The TDF group used transdermal fentanyl patches (TFPs) 25 μg/h applied 10 h preoperative then PVB with 20 mL of bupivacaine 0...
October 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28942032/post-mortem-review-of-fentanyl-related-overdose-deaths-among-identified-drug-users-in-southern-bavaria-germany-2005-2014
#12
Inga Sinicina, Hans Sachs, Wolfgang Keil
BACKGROUND: Two decades ago, there were only single case reports on deaths in Europe following the consumption of illicitly manufactured fentanyl by problem drug users. Today, lethal fentanyl intoxication is now no longer a rarity. Since 2005, a rapid increase of lethal fentanyl-related intoxications in the drug scene has been observed at the Institute of Legal Medicine, Ludwig Maximilians University, Munich. We hypothesized that this rise is the result of the launch of fentanyl matrix patches in Germany in 2004, their broad acceptance, their diversion from the regulated supply chain, and incautious prescription by medical care providers...
September 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28903827/pharmacokinetics-of-a-transdermal-fentanyl-solution-in-suffolk-sheep-ovis-aries
#13
Kimberly Y Jen, Melissa C Dyson, Patrick A Lester, Jean A Nemzek
Sheep used as surgical models require appropriate pain management, and the commonly used transdermal fentanyl patches require a long predosing period to achieve adequate plasma concentrations. The aim of this study was to assess the pharmacokinetic parameters of an FDA-approved transdermal fentanyl solution (TFS) that has yet to be tested in sheep. In this study, we compared TFS at 2.7 mg/kg (n = 2), 1.7 mg/kg (n = 3), and 0.5 mg/kg (n = 3) with the control fentanyl patch at 2 μg/kg/h (n = 1); both products were applied topically to the intrascapular region...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28890568/transdermal-fentanyl-patch-in-post-operative-patients-is-it-justified
#14
Abhijit S Nair
No abstract text is available yet for this article.
August 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28877414/evaluation-of-the-analgesic-and-pharmacokinetic-properties-of-transdermally-administered-fentanyl-in-goats
#15
Megan J Burke, Lawrence R Soma, Raymond C Boston, Jeffery A Rudy, Thomas P Schaer
OBJECTIVE: Evaluate the analgesic properties and pharmacokinetics of transdermal fentanyl patches (TFPs) in goats. DESIGN: Prospective, randomized study. SETTING: Preclinical Testing Facility at a University Teaching Hospital. ANIMALS: Thirty-four adult female Boer-cross goats. INTERVENTIONS: Goats underwent surgery as part of a concurrent orthopedic research study. Twelve hours prior to surgery, each goat received a TFP (target dosage of 2...
September 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28860851/transdermal-buprenorphine-and-fentanyl-patches-in-cancer-pain-a-network-systematic-review
#16
REVIEW
Jin Seok Ahn, Johnson Lin, Setsuro Ogawa, Chen Yuan, Tony O'Brien, Brian Hc Le, Andrea M Bothwell, Hanlim Moon, Yacine Hadjiat, Abhijith Ganapathi
Treatment of cancer pain is generally based on the three-step World Health Organization (WHO) pain relief ladder, which utilizes a sequential approach with drugs of increasing potency. Goals of pain management include optimization of analgesia, optimization of activities of daily living, minimization of adverse effects, and avoidance of aberrant drug taking. In addition, it is recommended that analgesic regimens are individualized and simplified to help ensure patient compliance and should provide the least invasive, easiest, and safest route of opioid administration to ensure adequate analgesia...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28813614/experiences-with-cutting-matrix-fentanyl-patches-as-a-method-of-dose-titration-in-cancer-patients
#17
Phoebe Tsz Man Cheng, Philippa Hawley
No abstract text is available yet for this article.
December 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28803080/palliative-care-development-in-kyrgyzstan
#18
Aibek Mukambetov, Taalaigul Sabyrbekova, Lola Asanalieva, Ilim Sadykov, Alexander Aralbaev, Stephen Connor
Palliative care began in Kyrgyzstan in 2005 as a pilot home based care program in Osh Cancer Center and was supported by a small group of nurses and one physician from Scotland. In 2010, the Soros Foundation-Kyrgyzstan (SFK) and the Open Society Foundation's International Palliative Care Initiative (IPCI) began supporting work on palliative care policy, legislation, essential medicine availability, education, advocacy and implementation. A Ministry of Health working group was established to lead this initiative and technical assistance was provided by an international palliative care consultant...
August 9, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28650373/fentanyl-patch-not-adhering-properly-during-use
#19
Ann Shastay
No abstract text is available yet for this article.
July 2017: Home Healthcare Now
https://www.readbyqxmd.com/read/28650234/antinociceptive-and-respiratory-effects-following-application-of-transdermal-fentanyl-patches-and-assessment-of-brain-%C3%AE-opioid-receptor-mrna-expression-in-ball-pythons
#20
Rima J Kharbush, Allison Gutwillig, Kate E Hartzler, Rebecca S Kimyon, Alyssa N Gardner, Andrew D Abbott, Sherry K Cox, Jyoti J Watters, Kurt K Sladky, Stephen M Johnson
OBJECTIVE To quantify plasma fentanyl concentrations (PFCs) and evaluate antinociceptive and respiratory effects following application of transdermal fentanyl patches (TFPs) and assess cerebrospinal μ-opioid receptor mRNA expression in ball pythons (compared with findings in turtles). ANIMALS 44 ball pythons (Python regius) and 10 turtles (Trachemys scripta elegans). PROCEDURES To administer 3 or 12 μg of fentanyl/h, a quarter or whole TFP (TFP-3 and TFP-12, respectively) was used. At intervals after TFP-12 application in snakes, PFCs were measured by reverse-phase high-pressure liquid chromatography...
July 2017: American Journal of Veterinary Research
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