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https://www.readbyqxmd.com/read/29678648/determinants-of-health-related-quality-of-life-1-year-after-pulmonary-thromboendarterectomy
#1
Oksana Kamenskaya, Asya Klinkova, Irina Loginova, Alexander Chernyavskiy, Alexander Edemskiy, Vladimir V Lomivorotov, Alexander Karaskov
AIM: Pulmonary thromboendarterectomy (PTE) is a recognized treatment for patients with chronic thromboembolic pulmonary hypertension (CTEPH), with good long-term haemodynamic results. The aim of this study was to test the hypothesis that the dynamics of health-related quality of life (QoL), 1 year after PTE, depends both on the clinical determinants associated with the underlying disease and the adverse events occurring in the early postoperative period. METHODS: This prospective cohort study included 136 patients with CTEPH...
April 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29676801/prolonged-prenatal-hypoxia-selectively-disrupts-collecting-duct-patterning-and-postnatal-function-in-male-mouse-offspring
#2
Sarah L Walton, Reetu R Singh, Melissa H Little, Josephine Bowles, Joan Li, Karen M Moritz
KEY POINTS SUMMARY: In this study we investigated whether hypoxia during late pregnancy impairs kidney development in mouse offspring, and also whether this has long-lasting consequences affecting kidney function in adulthood. Hypoxia disrupted growth of the kidney, particularly the collecting duct network, in juvenile male offspring. By mid-late adulthood, these mice developed early signs of kidney disease, notably a compromised response to water deprivation. Female offspring showed no obvious signs of impaired kidney development and did not develop kidney disease, suggesting a underlying protection mechanism from the hypoxia insult...
April 20, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29676618/cancer-risk-from-paediatric-computed-tomography-scanning-implications-for-radiation-protection-in-medicine
#3
A Kesminiene, E Cardis
The use of computed tomography (CT) imaging is clearly beneficial for millions of patients. However, the potential adverse health effects, particularly cancer, of ionising radiation exposure from CT early in life are an issue of growing concern in the radiological protection, medical, and public health communities. Although efforts to quantify these effects have been conducted, the precision and accuracy of reported risks needs confirmation. EPI-CT, a European collaborative epidemiological study, was set up to quantify risks from paediatric CT to optimise paediatric diagnostic protocol...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29672100/childhood-trauma-pubertal-timing-and-cardiovascular-risk-in-adulthood
#4
Man-Kit Lei, Steven R H Beach, Ronald L Simons
OBJECTIVE: An association between childhood trauma and adult health outcomes has been widely reported, but little is known about the developmental pathways through which childhood trauma influences adult cardiovascular disease (CVD). METHOD: Hypotheses were tested with a sample of 405 African Americans from the Family and Community Health Study (FACHS). Path modeling was used to test our theoretical model. RESULTS: Replicating prior research, exposure to childhood trauma was associated positively with increases in symptoms of CVD risk across young adulthood even after controlling for a variety of health-related and health behavior covariates...
April 19, 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29670651/the-comparison-between-endoscopic-submucosal-dissection-and-surgery-in-gastric-cancer-a-systematic-review-and-meta-analysis
#5
REVIEW
Junbi Hu, Yan Zhao, Mudan Ren, Yarui Li, Xinlan Lu, Guifang Lu, Dan Zhang, Dake Chu, Shuixiang He
Aims: There are two treatment modalities for early gastric cancer (EGC)-surgery and endoscopic submucosal dissection (ESD). We aimed to compare the safety and efficacy of ESD with surgery. Method: The article was performed by searching PubMed databases. Data were extracted using predefined form and odds ratios (OR) with 95% confidence intervals (CI) calculated and P value. Results: 13 studies were identified. The incidence of perforation in two groups was different [OR = 6...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29670486/utilizing-animal-models-of-infantile-spasms
#6
Chris G Dulla
Infantile spasms are a devastating epileptic encephalopathy characterized by early life spasms and later seizures. Clinical outcomes of infantile spasms are poor and therapeutic options are limited with significant adverse effects. Therefore, new strategies to treat infantile spasms are of the utmost importance. Animals models of infantile spasms are a critical component of developing new therapies. Here, we review current chronic animal models of infantile spasms and consider future advances that may help improve patient care, as well as our scientific understanding of this debilitating disease...
March 2018: Epilepsy Currents
https://www.readbyqxmd.com/read/29669332/paritaprevir-ritonavir-ombitasvir-plus-dasabuvir-regimen-in-the-treatment-of-genotype-1-chronic-hepatitis-c-infection-in-patients-with-severe-renal-impairment-and-end-stage-renal-disease-a-real-life-cohort
#7
Jan Sperl, Miluse Kreidlova, Dusan Merta, Klara Chmelova, Renata Senkerikova, Sona Frankova
BACKGROUND/AIMS: Chronic hepatitis C (HCV) virus infection reactivates under immunosuppressive drugs and therefore has a negative impact on long-term survival of kidney transplant recipients. Treatment-induced clearance of hepatitis C virus (HCV) in kidney transplant candidates prevents virus reactivation after transplantation. Paritaprevir/Ritonavir/Ombitasvir with Dasabuvir (PrOD) represents a highly effective treatment regimen for HCV genotype 1 (GT1), also suitable for patients with end-stage renal disease (ESRD)...
April 13, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29663599/greater-caregiving-risk-better-infant-memory-performance
#8
Anne Rifkin-Graboi, Jeffry Quan, Jenny Richmond, Shaun Kok Yew Goh, Lit Wee Sim, Yap Seng Chong, Jean Francois-Bureau, Helen Chen, Anqi Qiu
Poor early life care often relates to cognitive difficulties. However, newer work suggests that in early-life, adversity may associate with enhanced or accelerated neurodevelopment. We examine associations between postnatal caregiving risks (i.e., higher self-reported postnatal-anxiety and lower observed maternal sensitivity) and infant relational memory (i.e. via deferred imitation and relational binding). Using subsamples of 67-181 infants (aged 433-477 post-conceptual days, or roughly five to seven months since birth) taking part in the GUSTO study, we found such postnatal caregiving risk significantly predictive of "better" performance on a relational binding task following a brief delay, after Bonferroni adjustments...
April 16, 2018: Hippocampus
https://www.readbyqxmd.com/read/29663328/gamma-aminobutyric-acid-agonists-for-antipsychotic-induced-tardive-dyskinesia
#9
REVIEW
Samer Alabed, Youssef Latifeh, Husam Aldeen Mohammad, Hanna Bergman
BACKGROUND: Chronic antipsychotic drug treatment may cause tardive dyskinesia (TD), a long-term movement disorder. Gamma-aminobutyric acid (GABA) agonist drugs, which have intense sedative properties and may exacerbate psychotic symptoms, have been used to treat TD. OBJECTIVES: 1. Primary objectiveThe primary objective was to determine whether using non-benzodiazepine GABA agonist drugs for at least six weeks was clinically effective for the treatment of antipsychotic-induced TD in people with schizophrenia, schizoaffective disorder or other chronic mental illnesses...
April 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29656595/pathways-of-association-from-stress-to-obesity-in-early-childhood
#10
REVIEW
Alison L Miller, Julie C Lumeng
OBJECTIVE: The objective of this study is to critically review the literature on early life stress in relation to obesity in humans, including the multiple biological and behavioral mechanisms through which early life stress exposure (birth to the age of 5 years) may associate with obesity risk during childhood. METHODS: A review of the literature was conducted to identify studies on associations between early childhood stress and risk for obesity and the mechanisms of association...
April 14, 2018: Obesity
https://www.readbyqxmd.com/read/29651362/permanent-unilateral-hearing-loss-uhl-and-childhood-development
#11
REVIEW
Judith E C Lieu
Purpose of Review: The aim of this study is to summarize the consequences of permanent unilateral hearing loss (UHL) on the development of children as documented in the recent literature. Recent Findings: Congenital and early-identified UHL places young children at risk for delays in speech-language development. School-aged children with UHL score lower on standardized tests of language and cognition and need increased assistance in school for educational and behavioral issues than siblings with normal hearing, and report lower hearing-related quality of life, similar to children with bilateral hearing loss (HL)...
2018: Current Otorhinolaryngology Reports
https://www.readbyqxmd.com/read/29628283/weathering-the-storm-a-review-of-pre-pregnancy-stress-and-risk-of-spontaneous-abortion
#12
REVIEW
Tyralynn Frazier, Carol J Rowland Hogue, Elizabeth A Bonney, Kathryn M Yount, Brad D Pearce
The Weathering Effect is a theory that links stress exposure, over the life-course, with racial disparities in reproductive outcomes, through the effects of social adversity on a woman's body. The concept of maternal "weathering" captures cumulative somatic and psychological adversities that can exacerbate the effects of aging. Much of the evidence for weathering comes from observational studies linking self-report measures with reproductive outcomes. The purpose of this review is to explore biological mechanisms that underlie these observations...
March 1, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29627759/maternal-exposure-to-particulate-matter-alters-early-post-natal-lung-function-and-immune-cell-development
#13
Ling Chen, Ellen Bennett, Amanda J Wheeler, A Bruce Lyons, Gregory M Woods, Fay Johnston, Graeme R Zosky
BACKGROUND: In utero exposure to particulate matter (PM) from a range of sources is associated with adverse post-natal health; however, the effect of maternal exposure to community-sampled PM on early post-natal lung and immune development is poorly understood. OBJECTIVES: Using a mouse model, we aimed to determine whether in utero exposure to PM alters early post-natal lung function and immune cell populations. We used PM collected from ceiling voids in suburban houses as a proxy for community PM exposure...
April 5, 2018: Environmental Research
https://www.readbyqxmd.com/read/29626828/higher-concentration-of-interleukin-6-a-possible-link-between-major-depressive-disorder-and-childhood-abuse
#14
Ana Munjiza, Milutin Kostic, Danilo Pesic, Milan Gajic, Ivanka Markovic, Dusica Lecic Tosevski
Little is known about the correlation between IL-6 and childhood abuse and neglect which may be risk factors for the development of affective disorders in adulthood. The aim of this study was to analyze differences in serum concentrations of IL-6 between patients with major depressive disorder and healthy controls, and to investigate possible correlations with adverse childhood experiences. Peripheral venous blood samples were obtained from 64 patients who fulfilled DSM-IV-R criteria for a current major depressive episode without psychotic symptoms (MDD) and 53 healthy controls, matched for age and gender...
March 28, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29626662/can-early-life-growth-disruptions-predict-longevity-testing-the-association-between-vertebral-neural-canal-vnc-size-and-age-at-death
#15
Alexandra Amoroso, Susana J Garcia
This study tests the association of vertebral neural canal (VNC) size and age-at-death in a Portuguese skeletal collection from the 19th -20th century. If the plasticity and constraint model best explains this association, VNC size would be negatively related to mortality risk. If the predictive adaptive response (PAR) model is a better fit, no association can be inferred between VNC size and age-at-death. Ninety individuals were used in this study. The anteroposterior and transverse diameters of all vertebrae were measured...
April 4, 2018: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29625591/neurodevelopmental-assessment-of-hiv-exposed-uninfected-and-early-treated-hiv-infected-children-study-protocol
#16
Renate Strehlau, Tamryn van Aswegen, Joanne Potterton
OBJECTIVE: Sub-Saharan Africa has the highest prevalence of children at risk of not achieving their developmental potential, attributable largely to the human immunodeficiency virus (HIV) pandemic coupled with negative environmental factors. Childhood developmental stimulation programmes can mitigate adverse outcomes. METHODS: Neonates testing HIV positive at birth will be initiated on antiretroviral treatment (ART) and receive an age-appropriate stimulation program, updated at 3 monthly intervals through the first year of life...
April 6, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29625345/toward-an-adverse-outcome-pathway-for-impaired-growth-mitochondrial-dysfunction-impairs-growth-in-early-life-stages-of-the-fathead-minnow-pimephales-promelas
#17
Derek G Bolser, David A Dreier, Erchao Li, Kevin J Kroll, Christopher J Martyniuk, Nancy D Denslow
Chemical contaminants present in the environment can affect mitochondrial bioenergetics in aquatic organisms and can have substantial effects on individual fitness. As early life stages of fish are particularly vulnerable to environmental contaminants, they are ideal models for examining the relationship between impaired mitochondrial bioenergetics (ATP-dependent respiration, basal oxidative respiration) and apical endpoints such as growth. Here, early life stages of the fathead minnow (Pimephales promelas), an ecologically relevant North American species, were used to investigate the relationship between mitochondrial bioenergetics and growth following perturbation with model mitochondrial toxicants 2,4-dinitrophenol and octylamine...
April 3, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29619415/daclatasvir-and-sofosbuvir-treatment-of-decompensated-liver-disease-or-post-liver-transplant-hepatitis-c-virus-recurrence-in-patients-with-advanced-liver-disease-cirrhosis-in-a-real-world-cohort
#18
Paul Kwo, Michael W Fried, K Rajender Reddy, Consuelo Soldevila-Pico, Saro Khemichian, Jama Darling, Phillippe J Zamor, Andrew A Napoli, Beatrice Anduze-Faris, Robert S Brown
We report the findings of an early access program providing treatment for chronic hepatitis C virus infection (any genotype) with daclatasvir and sofosbuvir with/without ribavirin to patients with Child-Pugh class C cirrhosis or prior liver transplant recipients with recurrent hepatitis C virus infection and advanced fibrosis/cirrhosis. Patients had <12-month life expectancies per the local investigator. Patients received daclatasvir 60 mg and sofosbuvir 400 mg once daily, with/without ribavirin, for 24 weeks...
April 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29619148/association-of-serum-25-hydroxyvitamin-d-levels-and-liver-enzymes-in-a-nationally-representative-sample-of-iranian-adolescents-the-childhood-and-adolescence-surveillance-and-prevention-of-adult-noncommunicable-disease-study
#19
Maryam Bahreynian, Mostafa Qorbani, Mohammad Esmaeil Motlagh, Ramin Heshmat, Majid Khademian, Roya Kelishadi
Background: Hypovitaminosis D is highly prevalent and has several adverse health effects. This study aims to assess the relationship of serum concentrations of 25-hydroxyvitamin D (25[OH] D) and liver enzymes in adolescents. Methods: This population-based cross-sectional survey was conducted among a nationally representative multistage sample of 1095 adolescents (52% boys), aged 10-18 years, living in different provinces of Iran. Serum 25(OH)D concentration <30 ng/mL was considered as hypovitaminosis D, and liver enzymes (alanine aminotransaminase [ALT] and aspartate aminotransaminase [AST]) of >40 U/L was considered as high level...
2018: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29615218/placental-promoter-methylation-of-dna-repair-genes-and-prenatal-exposure-to-particulate-air-pollution-an-environage-cohort-study
#20
Kristof Y Neven, Nelly D Saenen, Letitzia Tarantini, Bram G Janssen, Wouter Lefebvre, Charlotte Vanpoucke, Valentina Bollati, Tim S Nawrot
BACKGROUND: Exposure to particulate air pollution has been linked with risk of carcinogenesis. Damage to repair pathways might have long-term adverse health effects. We aimed to investigate the association of prenatal exposure to air pollution with placental mutation rate and the DNA methylation of key placental DNA repair genes. METHODS: This cohort study used data from the ongoing ENVironmental Influence ON early AGEing (ENVIRONAGE) birth cohort, which enrols pairs of mothers and neonates (singleton births only) at the East-Limburg Hospital (Genk, Belgium)...
April 2018: Lancet. Planetary Health
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