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early life adversity

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https://www.readbyqxmd.com/read/29451946/first-experience-in-switzerland-in-phe508del-homozygous-cystic-fibrosis-patients-with-end-stage-pulmonary-disease-enrolled-in-a-lumacaftor-ivacaftor-therapy-trial-preliminary-results
#1
Christian Murer, Lars Christian Huber, Thomas Kurowski, Astrid Hirt, Cécile A Robinson, Urs Bürgi, Christian Benden
AIMS OF THE STUDY: Cystic fibrosis is the most common genetic disorder in Caucasians. The combination of the cystic fibrosis transmembrane conductance regulator (CFTR) corrector lumacaftor / potentiator ivacaftor (LUM/IVA) has been shown to increase forced expiratory volume in 1 second (FEV1) moderately, but predominantly reduce acute exacerbation rate (AER) in Phe508del homozygous cystic fibrosis patients; however, patients with FEV1 <40% predicted were excluded from studies. We used LUM/IVA on a "compassionate use" basis in cystic fibrosis patients with end-stage pulmonary disease...
February 16, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29449894/personalization-of-regorafenib-treatment-in-metastatic-gastrointestinal-stromal-tumours-in-real-life-clinical-practice
#2
Margherita Nannini, Maria Concetta Nigro, Bruno Vincenzi, Elena Fumagalli, Giovanni Grignani, Lorenzo D'Ambrosio, Giuseppe Badalamenti, Lorena Incorvaia, Raffaella Bracci, Silvia Gasperoni, Maristella Saponara, Lidia Gatto, Valentina Indio, Annalisa Astolfi, Valerio Di Scioscio, Paolo G Casali, Giuseppe Tonini, Massimo Aglietta, Antonio Russo, Guido Biasco, Maria A Pantaleo
Background: Regorafenib (REG) has now been approved as the standard third-line therapy in metastatic gastrointestinal stromal tumour (GIST) patients at the recommended dose and schedule of 160 mg once daily for the first 3 weeks of each 4-week cycle. However, it has a relevant toxicity profile that mainly occurs within the first cycles of therapy, and dose and schedule adjustments are often required to reduce the frequency or severity of adverse events and to avoid early treatment discontinuation...
December 2017: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29447460/the-curvilinear-relationship-of-early-life-adversity-and-successful-aging-the-mediating-role-of-mental-health
#3
Jan Höltge, Shauna L Mc Gee, Myriam V Thoma
OBJECTIVES: The steeling effect suggests that early-life adversity can have a beneficial impact later in life. However, little is known about its underlying mechanisms and long-term outcomes . The study aimed to examine the role of early-life adversity (ELA) on successful aging, and whether this relationship can be explained by mental and physical health. METHOD: Socio-demographics, early-life adversity (ELA), individual quality of life (iQoL), and mental and physical health of 270 individuals (M age = 66...
February 15, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29447162/early-experiences-mediate-distinct-adult-gene-expression-and-reproductive-programs-in-caenorhabditis-elegans
#4
Maria C Ow, Kirill Borziak, Alexandra M Nichitean, Steve Dorus, Sarah E Hall
Environmental stress during early development in animals can have profound effects on adult phenotypes via programmed changes in gene expression. Using the nematode C. elegans, we demonstrated previously that adults retain a cellular memory of their developmental experience that is manifested by differences in gene expression and life history traits; however, the sophistication of this system in response to different environmental stresses, and how it dictates phenotypic plasticity in adults that contribute to increased fitness in response to distinct environmental challenges, was unknown...
February 15, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29445512/changes-in-tear-volume-and-ocular-symptoms-of-patients-receiving-oral-anticancer-drug-s-1
#5
Reiko Kuriki, Tsuyoshi Hata, Kinuyo Nakayama, Yuichi Ito, Kazunari Misawa, Seiji Ito, Michiko Tatematsu, Norio Kaneda
Background: Most eye disorders are not fatal but may deteriorate the quality of life of a patient. The eye disorder that is most frequently reported in the cancer chemotherapy is associated with the combination of tegafur/gimeracil/potassium oxonate (S-1). However, preventive methods or treatment methods for the eye disorder have not yet been established. This study aimed to determine changes in tear volume and subjective ocular symptoms during the treatment period in patients receiving S-1 monotherapy for early detection of adverse effects in the eye and establishment of its treatment methods...
2018: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/29445306/repository-corticotropin-injection-in-patients-with-rheumatoid-arthritis-resistant-to-biologic-therapies
#6
Peter A Fischer, Ronald J Rapoport
Introduction: Although synthetic and biologic disease-modifying antirheumatic drugs are available, many patients with rheumatoid arthritis have a difficult-to-control disease and need other treatment options. Repository corticotropin injection (RCI) may alleviate symptoms and exacerbations in patients with refractory disease. Methods: Nine patients with refractory rheumatoid arthritis were included in this study. Patients were maintained on their baseline therapies with a minimum of 7...
2018: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/29442401/single-arm-phase-ii-study-of-oral-vitamin-b12-for-the-treatment-of-musculoskeletal-symptoms-associated-with-aromatase-inhibitors-in-women-with-early-stage-breast-cancer
#7
Aleli Campbell, Rosalinda Heydarian, Cecilia Ochoa, Alok Kumar Dwivedi, Zeina A Nahleh
Breast cancer patients receiving endocrine therapy with aromatase Inhibitors (AIs) often experience musculoskeletal and joint-related side effects. The purpose of this study was to evaluate the effect of Vitamin B12 supplements on musculoskeletal symptoms such as pain and arthralgias induced by AIs and to correlate response with serum and inflammatory biomarkers. Upon receiving approval by the Institutional Review Board (IRB), the majority of the patients consented into the study were treated at the Texas Tech Breast Care Center...
February 14, 2018: Breast Journal
https://www.readbyqxmd.com/read/29442014/improvement-of-treatment-outcomes-after-implementation-of-comprehensive-pharmaceutical-care-in-breast-cancer-patients-receiving-everolimus-and-exemestane
#8
M Todo, S Ueda, S Osaki, I Sugitani, T Takahashi, M Takahashi, H Makabe, T Saeki, Y Itoh
Combination therapy with everolimus and an aromatase inhibitor such as exemestane is an effective treatment option for advanced or recurrent breast cancer. However, the therapy is often limited because of the occurrence of severe adverse events (AEs), including oral mucositis, interstitial lung disease, diarrhea, and rash. Therefore, early management of AEs is extremely important to obtain maximum treatment outcome. We investigated here the effects of comprehensive pharmaceutical care for prevention of severe AEs on patient's quality-of-life (QOL) and continuation of therapy...
February 1, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29440285/nutrient-intake-in-the-first-two-weeks-of-life-and-brain-growth-in-preterm-neonates
#9
Juliane Schneider, Céline J Fischer Fumeaux, Emma G Duerden, Ting Guo, Justin Foong, Myriam Bickle Graz, Patric Hagmann, M Mallar Chakravarty, Petra S Hüppi, Lydie Beauport, Anita C Truttmann, Steven P Miller
BACKGROUND: Optimizing early nutritional intake in preterm neonates may promote brain health and neurodevelopment through enhanced brain maturation. Our objectives were (1) to determine the association of energy and macronutrient intake in the first 2 weeks of life with regional and total brain growth and white matter (WM) maturation, assessed by 3 serial MRI scans in preterm neonates; (2) to examine how critical illness modifies this association; and (3) to investigate the relationship with neurodevelopmental outcomes...
February 13, 2018: Pediatrics
https://www.readbyqxmd.com/read/29440004/age-at-menarche-and-cardiometabolic-health-a-sibling-analysis-in-the-scottish-family-health-study
#10
Maria C Magnus, Debbie A Lawlor, Stamatina Iliodromiti, Sandosh Padmanabhan, Scott M Nelson, Abigail Fraser
BACKGROUND: Previous studies of age at menarche and cardiometabolic health report conflicting findings, and only a few could account for childhood characteristics. We aimed to estimate the associations of age at menarche with cardiovascular risk factors in unrelated women and within sister groups, under the assumption that within-sibship estimates will be better adjusted for shared genetics and early life environment. METHODS AND RESULTS: Our study included 7770 women, from 5984 sibships, participating in the GS:SFHS (Generation Scotland: Scottish Family Health Study)...
February 10, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29439772/stomatitis-associated-with-mammalian-target-of-rapamycin-inhibition-a-review-of-pathogenesis-prevention-treatment-and-clinical-implications-for-oral-practice-in-metastatic-breast-cancer
#11
Mark S Chambers, Hope S Rugo, Jennifer K Litton, Timothy F Meiller
BACKGROUND: Patients with metastatic breast cancer may develop oral morbidities that result from therapeutic interventions. Mammalian target of rapamycin (mTOR) inhibitor-associated stomatitis (mIAS) is a common adverse event (AE), secondary to mTOR inhibitor therapy, that can have a negative impact on treatment adherence, quality of life, and health care costs. A multidisciplinary team approach is important to minimize mIAS and to maximize treatment benefits to patients with breast cancer...
February 10, 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29439736/clinical-evaluation-of-two-different-protein-content-formulas-fed-to-full-term-healthy-infants-a-randomized-controlled-trial
#12
Liotto Nadia, Orsi Anna, Menis Camilla, Piemontese Pasqua, Morlacchi Laura, Condello Chiara Cristiana, Giannì Maria Lorella, Roggero Paola, Mosca Fabio
BACKGROUND: A high early protein intake is associated with rapid postnatal weight gain and altered body composition. We aimed to evaluate the safety of a low-protein formula in healthy full-term infants. METHODS: A randomized controlled trial was conducted. A total of 118 infants were randomized to receive two different protein content formulas (formula A or formula B (protein content: 1.2 vs. 1.7 g/100 mL, respectively)) for the first 4 months of life. Anthropometry and body composition by air displacement plethysmography were assessed at enrolment and at two and 4 months...
February 13, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29439389/early-life-exposure-to-non-nutritive-sweeteners-and-the-developmental-origins-of-childhood-obesity-global-evidence-from-human-and-rodent-studies
#13
REVIEW
Alyssa J Archibald, Vernon W Dolinsky, Meghan B Azad
Non-nutritive sweeteners (NNS) are increasingly consumed by children and pregnant women around the world, yet their long-term health impact is unclear. Here, we review an emerging body of evidence suggesting that early-life exposure to NNS may adversely affect body composition and cardio-metabolic health. Some observational studies suggest that children consuming NNS are at increased risk for obesity-related outcomes; however, others find no association or provide evidence of confounding. Fewer studies have examined prenatal NNS exposure, with mixed results from different analytical approaches...
February 10, 2018: Nutrients
https://www.readbyqxmd.com/read/29438728/long-term-early-life-adverse-experience-impairs-responsiveness-to-exteroceptive-stimuli-in-adult-rats
#14
Anna Holubová, Anna Mikulecká, Marie Pometlová, Kateryna Nohejlová, Romana Šlamberová
It has been shown that early life traumatic events strongly alter the physiology and behavior in adult rats. In the present study, the effect of postnatal stressor on the spontaneous behavior of adult male rats was evaluated. A method of positive habituation based on a detailed analysis of behavioral patterns and attention of animals to a stimulus object was used. Twenty-four dams and twenty-four of their male progeny were used. Pups were divided into three groups (n = 8): controls (C); maternal social stressor (S); maternal social and physical stressors (SW)...
February 10, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29433073/link-between-children-s-hair-cortisol-and-psychopathology-or-quality-of-life-moderated-by-childhood-adversity-risk
#15
Anna Fuchs, Charlotte Jaite, Corinne Neukel, Katja Dittrich, Katja Bertsch, Dorothea Kluczniok, Eva Möhler, Catherine Hindi Attar, Romuald Brunner, Katja Bödeker, Franz Resch, Felix Bermpohl, Michael Kaess
The hypothalamus-pituitary-adrenal axis (HPAA) and its end product, the glucocorticoid cortisol, has been shown to be associated with psychopathology. Determining cortisol concentrations in hair (HCC) allows the investigation of long-term HPAA-activity. There is a significant scarcity of studies investigating the link between HCC and psychopathology and quality of life in child and adolescent samples. In addition, as the HPAA constitutes a feedback system enabling adaption to environmental demands, it is important to consider the socio-environmental context that the children grow up in...
February 6, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29432620/association-of-bdnf-val66met-polymorphism-and-brain-bdnf-levels-with-major-depression-and-suicide
#16
Mariam M Youssef, Mark D Underwood, Yung-Yu Huang, Shu-Chi Hsiung, Yan Liu, Norman R Simpson, Mihran J Bakalian, Gorazd B Rosoklija, Andrew J Dwork, Victoria Arango, J John Mann
Background: Brain-derived neurotrophic factor (BDNF) is implicated in the pathophysiology of major depressive disorder (MDD) and suicide. Both are partly caused by early life adversity (ELA) and ELA reduces BDNF protein levels. This study examines the association of BDNF Val66Met polymorphism and brain BDNF levels with depression and suicide. We hypothesized that both MDD and ELA would be associated with the Met allele and lower brain BDNF levels. Such an association would be consistent with low BDNF mediating the effect of ELA on adulthood suicide and MDD...
February 8, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29432031/deferred-diagnosis-in-children-assessed-for-fetal-alcohol-spectrum-disorder
#17
Katherine Flannigan, Kamaldeep Gill, Jacqueline Pei, Gail Andrew, Hasu Rajani, Audrey McFarlane, Teresa O'Riordan, Brent Symes, Carmen Rasmussen
Early intervention for individuals with FASD is paramount, thus exploring factors that affect the diagnostic process is critical. This process can be complicated by challenges gathering background information, accurately evaluating higher-level cognitive skills across ages, and teasing apart the impact of life adversities from the effects of prenatal alcohol exposure. This study is a retrospective file review of 154 children (44% female; mean age 8.4 years, range 1.0 to 16.9) deferred at their first FASD assessment, and 51 (43% female; mean 9...
February 12, 2018: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/29430978/biomarkers-for-immune-related-toxicities-of-checkpoint-inhibitors-current-progress-and-the-road-ahead
#18
Pradnya D Patil, Mauricio Burotto, Vamsidhar Velcheti
Immune checkpoint pathways are key immune regulatory pathways that play a physiologic role in maintaining immune-homeostasis and are often co-opted by cancer cells to evade the host immune system. Recent developments in cancer immunotherapy, mainly drugs blocking the immune checkpoint pathways, have revolutionized the treatment paradigm for many solid tumors. A wide spectrum of immune-related adverse events (irAEs) have been described with the use of these agents which necessitate treatment with immunosuppression, leading to disruption of therapy and can on occasion be life-threatening...
February 10, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29426849/early-life-exposure-to-ethinylestradiol-enhances-subsequent-responses-to-environmental-estrogens-measured-in-a-novel-transgenic-zebrafish
#19
Jon M Green, Anke Lange, Aaron Scott, Maciej Trznadel, Htoo Aung Wai, Aya Takesono, A Ross Brown, Stewart F Owen, Tetsuhiro Kudoh, Charles R Tyler
Estrogen plays fundamental roles in a range of developmental processes and exposure to estrogen mimicking chemicals has been associated with various adverse health effects in both wildlife and human populations. Estrogenic chemicals are found commonly as mixtures in the environment and can have additive effects, however risk analysis is typically conducted for single-chemicals with little, or no, consideration given for an animal's exposure history. Here we developed a transgenic zebrafish with a photoconvertable fluorophore (Kaede, green to red on UV light exposure) in a skin pigment-free mutant element (ERE)-Kaede-Casper model and applied it to quantify tissue-specific fluorescence biosensor responses for combinations of estrogen exposures during early life using fluorescence microscopy and image analysis...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29426663/assessing-the-reactogenicity-of-tdap-vaccine-administered-during-pregnancy-and-antibodies-to-bordetella-pertussis-antigens-in-maternal-and-cord-sera-of-thai-women
#20
Nasamon Wanlapakorn, Kirsten Maertens, Surasith Chaithongwongwatthana, Donchida Srimuan, Narissara Suratannon, Sompong Vongpunsawad, Thao Mai Phuong Tran, Niel Hens, Pierre Van Damme, Camille Locht, Yong Poovorawan, Elke Leuridan
INTRODUCTION: Pregnant Thai women have low antibody titers against B. pertussis antigens, which coincide with an increasing incidence of pertussis among Thai infants. Thus, there exists a potential benefit of a booster dose of tetanus- diphtheria-acellular pertussis (Tdap) vaccine administered during pregnancy. Here, we report the vaccine reactogenicity profile and birth outcomes in Tdap-vaccinated pregnant women who have or have not had prior immunization with tetanus vaccine, and the IgG levels to B...
February 6, 2018: Vaccine
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