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https://www.readbyqxmd.com/read/29334655/how-yeast-coordinates-metabolism-growth-and-division
#1
REVIEW
Jennifer C Ewald
All cells, especially single cell organisms, need to adapt their metabolism, growth and division coordinately to the available nutrients. This coordination is mediated by extensive cross-talk between nutrient signaling, metabolism, growth, and the cell division cycle, which is only gradually being uncovered: Nutrient signaling not only controls entry into the cell cycle at the G1/S transition, but all phases of the cell cycle. Metabolites are even sensed directly by cell cycle regulators to prevent cell cycle progression in absence of sufficient metabolic fluxes...
January 12, 2018: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29334639/vestibular-schwannoma-and-hearing-preservation-usefulness-of-level-specific-ce-chirp-abr-monitoring-a-retrospective-study-on-25-cases-with-preoperative-socially-useful-hearing
#2
Luciano Mastronardi, Ettore Di Scipio, Guglielmo Cacciotti, Raffaelino Roperto
BACKGROUND AND OBJECTIVES: Decision-making regarding the therapy of vestibular schwannoma (VS) changed over the last decades, during which curative microsurgery has been promoted. Goals of VS microsurgery are: extensive resection, facial nerve (FN) preservation and, in selected cases, hearing preservation (HP). The aim of this study is to evaluate postoperative HP with reference to tumor size in patients operated on with Level Specific (LS)-CE-Chirp® ABR monitoring. PATIENTS AND METHODS: Twentyfive consecutive patients with socially useful hearing (SUH) underwent VS microneurosurgery by retrosigmoid (RS) approach...
January 10, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29334332/quantifying-lower-extremity-and-trunk-function-for-dressing-in-stroke-patients-a-retrospective-observational-study
#3
Takaaki Fujita, Atsushi Sato, Kazuaki Iokawa, Kazuhiro Yamane, Yuichi Yamamoto, Yoko Ohira, Koji Otsuki, Fusae Tozato
Background Dressing performance relates strongly with balance function, and it is mainly influenced by the motor functions of the affected and unaffected lower extremity and trunk function in stroke patients. For the remedial approach to be effective, ascertaining the degree of function needed in the affected and unaffected lower extremities and trunk to achieve balance function requisite for dressing is necessary. Objectives This study aimed to elucidate standards of lower extremity and trunk function necessary for stroke patients to gain balance requisite for dressing...
January 15, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29334284/surface-endoglin-cd105-expression-on-acute-leukemia-blast-cells-an-extensive-flow-cytometry-study-of-1002-patients
#4
Vincenzo Cosimato, Giulia Scalia, Maddalena Raia, Laura Gentile, Vincenza Cerbone, Feliciano Visconte, Teodora Statuto, Luciana Valvano, Fiorella D'Auria, Giovanni Calice, Daniela Graziano, Pellegrino Musto, Luigi Del Vecchio
No abstract text is available yet for this article.
January 15, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29334282/evaluation-of-dentin-permeability-of-fluorotic-permanent-teeth
#5
K Görkem Ulu Güzel, Münciye Semra Özay Ertürk, Zuhal Kırzıoğlu, Suat Özkorucuklu
OBJECTIVE: The in vitro permeability characteristics of dentin have been studied extensively and used to evaluate the efficacy of various preventative and restorative procedures. The aim of this in vitro study was to precisely determine the dentin permeability of fluorotic premolar teeth using an electronic hydraulic conductance measurement system with photosensors and to compare the data with healthy premolars. METHODS: In total, 40 fluorotic and healthy premolar teeth with complete root formation that were extracted for orthodontic purposes and had no caries, restoration, fractures, or cracks were selected for this study...
January 15, 2018: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29334258/two-new-phenylpropanoid-esters-from-bulbophyllum-retusiusculum
#6
Jing Sun, Li-Jun Chen, Yan Zhang, Rui Zhan, Ye-Gao Chen
Two new phenylpropanoid esters bobulretulates A (1) and B (2), together with eleven known compounds, were isolated from the whole plants of Bulbophyllum retusiusculum. Their structures were elucidated by means of extensive spectroscopic analysis.
January 15, 2018: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29334250/estimation-of-a-latent-variable-regression-growth-curve-model-for-individuals-cross-classified-by-clusters
#7
Audrey J Leroux, S Natasha Beretvas
The cross-classified multiple membership latent variable regression (CCMM-LVR) model is a recent extension to the three-level latent variable regression (HM3-LVR) model which can be utilized for longitudinal data that contains individuals who changed clusters over time (for instance, student mobility across schools). The HM3-LVR model can include the initial status on growth effect as varying across those clusters and allows testing of more flexible hypotheses about the influence of initial status on growth and of factors that might impact that relationship, but only in the presence of pure clustering of participants within higher-level units...
January 15, 2018: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/29334148/self-powered-si-cds-flexible-photodetector-with-broadband-response-from-325-to-1550-nm-based-on-pyro-phototronic-effect-an-approach-for-photosensing-below-bandgap-energy
#8
Yejing Dai, Xingfu Wang, Wenbo Peng, Cheng Xu, Changsheng Wu, Kai Dong, Ruiyuan Liu, Zhong Lin Wang
Cadmium sulfide (CdS) has received widespread attention as the building block of optoelectronic devices due to its extraordinary optoelectronic properties, low work function, and excellent thermal and chemical stability. Here, a self-powered flexible photodetector (PD) based on p-Si/n-CdS nanowires heterostructure is fabricated. By introducing the pyro-phototronic effect derived from wurtzite structured CdS, the self-powered PD shows a broadband response range, even beyond the bandgap limitation, from UV (325 nm) to near infrared (1550 nm) under zero bias with fast response speed...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29334143/childhood-alopecia-areata-data-from-the-national-alopecia-areata-registry
#9
Iris Wohlmuth-Wieser, Joyce S Osei, David Norris, Vera Price, Maria K Hordinsky, Angela Christiano, Madeleine Duvic
BACKGROUND/OBJECTIVES: Alopecia areata may occur at any age and is the third-most-common dermatosis in children. The objective of this study was to investigate the clinical and epidemiologic features of children and adolescents with alopecia areata based on the data of the National Alopecia Areata registry on children and adolescents. METHODS: Two thousand two hundred eighteen children and adolescents with alopecia areata self-enrolled in the National Alopecia Areata Registry and completed a web-based, self-administered, short-intake screening questionnaire (first tier)...
January 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29334121/the-multipotency-to-commitment-transition-mct-in-c-elegans-implications-for-reprogramming-from-cells-to-organs
#10
REVIEW
Erik A Spickard, Pradeep M Joshi, Joel H Rothman
In animal embryos, cells transition from a multipotential state, with the capacity to adopt multiple fates, into an irreversible, committed state of differentiation. This multipotency-to-commitment transition (MCT) is evident from experiments in which cell fate is reprogrammed by transcription factors for cell-type-specific differentiation, as has been observed extensively in C. elegans. Although factors that direct differentiation into each of the three germ layer types cannot generally reprogram cells after the MCT in this animal, transcription factors for endoderm development are able to do so in multiple differentiated cell types...
January 15, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29334118/markers-of-proliferation-and-invasiveness-in-somatotropinomas
#11
Agata Baldys-Waligorska, Iga Wierzbicka, Grzegorz Sokolowski, Dariusz Adamek, Filip Golkowski
IntroductionIn the search for markers of invasiveness of pituitary adenomas, we studied the expression of Ki-67 antigen, TOPO 2A (topoisomerase 2 alpha), AIP (Aryl Hydrocarbon Receptor-Interacting Protein) and VEGF (Vascular Endothelial Growth Factor) in somatotropinomas.Material and MethodsWe retrospectively studied a group of 31 patients who underwent pituitary tumour surgery. Expression of Ki-67, TOPO 2A, AIP and VEGF in surgical specimens was determined by immunohistochemistry. Relations between quantitatively determined markers and clinical symptoms, tumour features, and MR imaging, were analysed...
January 15, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29334080/effects-of-microarchitecture-and-mechanical-properties-of-3d-microporous-plla-plga-scaffolds-on-fibrochondrocyte-and-l929-fibroblast-behavior
#12
Gokhan Bahcecioglu, Nesrin Hasırcı, Vasif Hasirci
There are several reports studying cell behavior on surfaces in 2D or in hydrogels in 3D. However, cell behavior in 3D microporous scaffolds has not been investigated extensively. In this study, poly(L-lactic acid)/poly(lactic acid-co-glycolic acid) (PLLA/PLGA)-based microporous scaffolds were used to study the effects of scaffold microarchitecture and mechanical properties on the behavior of two different cell types, human meniscal fibrochondrocytes and L929 mouse fibroblasts. In general, cell attachment, spreading and proliferation rate were mainly regulated by the strut stiffness...
January 15, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29333930/a-histological-analysis-of-artificial-skin-in-an-extensively-burned-child-14-years-after-application-a-case-report
#13
Robert Zajicek, Eva Sticova, Radana Königova
INTRODUCTION: Artificial skin has become the treatment of choice in extensive, full-thickness thermal injuries. The longest follow-up of the healing process in burn sites covered with the Integra Bilayer Matrix Wound Dressing onto the wound published to date was at around five years after application. In our case report, we describe the clinical and histological analysis of an extensive, full-thickness thermal injury 14 years on from treatment with the bilayer matrix wound dressing. CASE STUDY: A nine-year-old boy suffered a full-thickness skin loss over 85% of his body surface area following a fire accident...
January 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29333919/reconstruction-of-extensive-medial-canthal-defects-using-a-single-v-y-island-pedicle-flap
#14
Christopher M Stewart, Jonathan H Norris
The medial canthus represents one of the most challenging regions of the face to reconstruct due to the anatomical structures present, the concavity of the area, and the differences in skin texture. We present a case series of 11 patients whose defects were reconstructed with a single V-Y island pedicle flap running along the nasofacial sulcus. Our single-stage flap which modified and simplified a previously described technique achieves similar cosmetic and postoperative outcomes along with a high level of patient satisfaction in an area which can be reconstructed in a variety of ways, often with suboptimal results...
January 15, 2018: Orbit
https://www.readbyqxmd.com/read/29333848/highly-stable-and-luminescent-perovskite-polymer-composites-from-a-convenient-and-universal-strategy
#15
Yumeng Xin, Hongjie Zhao, Jiuyang Zhang
Extensive attention has been received in recent years for perovskite-polymer composites due to their combination of properties from polymers and perovskites. In this work, a convenient and universal strategy is reported to prepare cesium lead bromide (CsPbBr3) or organolead halide CH3NH3PbBr3 polymer composites. This technique integrates the formation of perovskite crystals and polymer matrix in a one-pot reaction, avoiding the tedious separation and preparation of perovskites. The method is universal for most of commercially available monomers and polymers, which has been verified in this report by poly(methyl methacrylate) (PMMA), poly(butyl methacrylate) (PBMA) and polystyrene (PS)...
January 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29333659/acute-renal-replacement-therapy-during-hospitalization-is-training-adequate
#16
Paul M Palevsky
Acute renal replacement therapy is one of the most common interventions provided by nephrologists, however, data on the quality of training provided to nephrology fellows is limited. Extensive curricula for acute renal replacement therapy and the management of poisonings and intoxications have been published, but personal experience suggests that there are significant opportunities to improve training. Particular areas to be considered include the use of novel technologies for assessment of volume status, greater emphasis on the dosing of medications during acute renal replacement therapy, greater training in assessing and tailoring treatment to the goals of care of the individual patient, incorporation of continuous quality improvement tools into the management of acute renal replacement therapy programs and development of robust simulation training to augment training...
January 14, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29333613/pharmacokinetics-pharmacodynamics-and-clinical-use-of-trazodone-and-its-active-metabolite-m-chlorophenylpiperazine-in-the-horse
#17
J L Davis, J Schirmer, E Medlin
Trazodone is a serotonin receptor antagonist and reuptake inhibitor used extensively as an anxiolytic in human and small animal veterinary medicine. The aims of this study were to determine the pharmacokinetics of oral trazodone in experimental horses and to evaluate the effect of oral trazodone in clinical horses. Six experimental horses were administered trazodone at 7.5 or 10 mg/kg. Plasma concentrations of trazodone and its metabolite (m-CPP) were determined via UPLC-MS/MS. Noncompartmental pharmacokinetic analysis, sedation and ataxia scores were determined...
January 14, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29333587/genetic-characterization-and-modification-of-a-bioethanol-producing-yeast-strain
#18
Ke Zhang, Ya-Nan Di, Lei Qi, Yang Sui, Ting-Yu Wang, Li Fan, Zhen-Mei Lv, Xue-Chang Wu, Pin-Mei Wang, Dao-Qiong Zheng
Yeast Saccharomyces cerevisiae strains isolated from different sources generally show extensive genetic and phenotypic diversity. Understanding how genomic variations influence phenotypes is important for developing strategies with improved economic traits. The diploid S. cerevisiae strain NY1308 is used for cellulosic bioethanol production. Whole genome sequencing identified an extensive amount of single nucleotide variations and small insertions/deletions in the genome of NY1308 compared with the S288c genome...
January 15, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29333400/brentuximab-vedotin-clinical-updates-and-practical-guidance
#19
REVIEW
Jun Ho Yi, Seok Jin Kim, Won Seog Kim
Brentuximab vedotin (BV), a potent antibody-drug conjugate, targets the CD30 antigen. Owing to the remarkable efficacy shown in CD30-positive lymphomas, such as Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma, BV was granted accelerated approval in 2011 by the US Food and Drug Administration. Thereafter, many large-scale trials in various situations have been performed, which led to extensions of the original indication. The aim of this review was to describe the latest updates on clinical trials of BV and the in-practice guidance for the use of BV...
December 2017: Blood Research
https://www.readbyqxmd.com/read/29333339/time-multiplexed-deep-reactive-ion-etching-of-germanium-and-silicon-a-comparison-of-mechanisms-and-application-to-x-ray-optics
#20
Vincent J Genova, David N Agyeman-Budu, Arthur R Woll
Although the mechanisms of deep reactive ion etching (DRIE) of silicon have been reported extensively, very little by comparison has been discussed concerning DRIE of germanium. By directly comparing silicon and germanium etching in a time multiplexed DRIE process, the authors extract significant differences in etch mechanisms from a design of experiment and discuss how these differences are relevant to the design and fabrication of silicon and germanium collimating channel array x-ray optics. The differences are illuminated by characteristics such as reactive ion etching (RIE)-lag, aspect ratio dependent etching, and sidewall passivation...
January 2018: Journal of Vacuum Science and Technology. B, Nanotechnology & Microelectronics: Materials, Processing, Measurement, & Phenomena: JVST B
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