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thrombosis in APML

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https://www.readbyqxmd.com/read/24046068/atra-induced-cerebral-sinus-thrombosis
#1
Kenneth Rohan Lee, Visvaraja Subrayan, Maung Maung Win, Nor Fadhilah Mohamad, Dinesh Patel
All-trans retinoic acid (ATRA) and Idarubicin are part of the AIDA protocol employed for the treatment of Acute promyelocytic leaukaemia (APML) and has been associated with marked improvement in the prognosis. However, it is known to worsen the haematological picture during the course of induction of therapy. Herein, we present a case of an APML patient who developed a rare documented incidence of cerebral sinus thrombosis, first noticed as an ophthalmology referral. This 22 year old lady, a known APML patient was then started on chemotherapy based on AIDA protocol but 17 days into the initiation of therapy, she began to complain of blurred vision on the right eye...
July 2014: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/18613223/acute-promyelocytic-leukaemia-and-acquired-alpha-2-plasmin-inhibitor-deficiency-a-retrospective-look-at-the-use-of-epsilon-aminocaproic-acid-amicar-in-30-patients
#2
T Wassenaar, J Black, B Kahl, B Schwartz, W Longo, D Mosher, E Williams
Bleeding diathesis and a hyper-fibrinolytic state often accompany a diagnosis of Acute Promyelocytic Leukaemia (APML). This complication can have grave effects if not successfully treated, with a 10-20% incidence of haemorrhagic death. We hypothesized that alpha-2-antiplasmin levels would correlate with the risk for bleeding, and that administration of epsilon-aminocaproic acid (EACA) would attenuate that risk. To assess this, we conducted a retrospective chart review analyzing 30 APML patients, 17 of whom were treated with EACA...
December 2008: Hematological Oncology
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