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https://www.readbyqxmd.com/read/29029002/infrared-intraoperative-fluorescence-imaging-using-indocyanine-green-in-thoracic-surgery
#1
Olugbenga T Okusanya, Nicholas R Hess, James D Luketich, Inderpal S Sarkaria
Thoracic surgery faces many unique challenges that require innovative solutions. The increase in utilization of minimally invasive practices, poor overall cancer survival and significant morbidity of key operations remain key obstacles to overcome. Intraoperative fluorescence imaging is a process by which fluorescent dyes and imaging systems are used as adjuncts for surgeons in the operating room. Other surgical subspecialists have shown that intraoperative fluorescence imaging can be applied as a practical adjunct to their practices...
September 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29028153/tailored-intraoperative-localization-of-non-palpable-pulmonary-lesions-for-thoracoscopic-wedge-resection-using-hybrid-room-technology
#2
Alessia Stanzi, Federico Mazza, Francesco Lucio, Donatella Ghirardo, Maurizio Grosso, Alessandro Locatelli, Giulio Melloni
INTRODUCTION: VATS wedge resection can require conversion to thoracotomy when pulmonary lesions cannot be identified. Hybrid operating rooms (HOR) provide real-time image acquisition capabilities allowing the intraoperative placement of markers, to facilitate the removal of non-palpable nodules during VATS. OBJECTIVES: To present our workflow based on the alternative use of two different markers according to the location of the lung lesion, and report our initial results...
October 13, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29028090/a-comparative-study-on-inflammatory-factors-and-immune-functions-of-lung-cancer-and-pulmonary-ground-glass-attenuation
#3
C-Y Liu, W-G Xie, S Wu, J-W Tian, J Li
OBJECTIVE: To compare the inflammatory factors and immune functions of patients with lung cancer and pulmonary ground-glass attenuation. PATIENTS AND METHODS: A total of 108 patients with pulmonary sarcoidosis treated in our hospital were selected and randomly divided into lung cancer group (Group A, n=32), diffuse ground-glass nodule group (Group B, n=35) and solitary ground-glass nodule group (Group C, n=41) according to the diagnosis results. Levels of inflammatory factors, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and interleukin-10 (IL-10), in serum were detected via enzyme-linked immunosorbent assay (ELISA); the T-lymphocyte subset levels (CD3+, CD4+, CD8+ and CD4+/CD8+) in the immune system of patients in the three groups were detected using the flow cytometer; the levels of immunoglobulins, immunoglobulin G (IgG), immunoglobulin A (IgA) and immunoglobulin M (IgM), were detected via immunoturbidimetric assay...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29026608/diffuse-idiopathic-pulmonary-neuroendocrine-cell-hyperplasia-diagnosed-by-tranbronchoscopic-cryoprobe-biopsy-technique
#4
Ravi Patel, Carolina Collazo-Gonzalez, Arthur Andrews, Jean Johnson, Mark Rumbak, Maxwell Smith
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) remains a poorly understood clinical entity. It is currently classified as a premalignant condition by the World Health Organization (WHO). Symptoms are similar to those associated with obstructive lung disease, including breathlessness and cough. The presentation is often initially ascribed to other diseases such as asthma or chronic obstructive pulmonary disease. Here, we present what we believe is the first described case of DIPNECH diagnosed by transbronchoscopic cryoprobe biopsy...
November 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/29026362/inflammatory-myofibroblastic-tumor-of-the-breast-mimicking-malignancy-in-an-elderly-male
#5
Fouzia Siraj, Manveen Kaur, Varsha Dalal, Jain Sonam
BACKGROUND: Inflammatory myofibroblastic tumor (IMT) is a rare, distinctive lesion composed of a proliferation of myofibroblastic spindle cells accompanied by an inflammatory infiltrate. It was first described in the lung, but its occurrence at various extrapulmonary sites has also been reported. The literature mentions only a handful of cases of IMT in the breast and only 1 case in the male breast. We report the second case of IMT in the male breast. CASE REPORT: A 60-year-old male presented with a large, lobulated lump in the left breast that had progressively increased in size during the past year...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29025986/-18-f-fluorodeoxyglycose-avid-thyroid-incidentalomas-the-importance-of-contextual-interpretation
#6
David A Pattison, Michael Bozin, Alexandra Gorelik, Michael S Hofman, Rodney J Hicks, Anita Skandarajah
Background: FDG-avid thyroid incidentalomas (TI) are seen in approximately 2.5% of patients imaged for staging or response assessment of malignancy and represent thyroid cancer in approximately 35% of cases. Consequently, the 2015 ATA guidelines strongly recommend investigation of all FDG-avid nodules ≥1cm with US and fine needle aspiration cytology (FNA). This study aims to assess the overall and thyroid cancer specific survival in a large cohort of patients with FDG-avid TI with long-term follow-up to assess the validity of this approach...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29022575/gefitinib-inhibits-m2-like-polarization-of-tumor-associated-macrophages-in-lewis-lung-cancer-by-targeting-the-stat6-signaling-pathway
#7
Muhammad Tariq, Jie-Qiong Zhang, Gui-Kai Liang, Qiao-Jun He, Ling Ding, Bo Yang
M2-like polarized tumor-associated macrophages (TAMs) play a pivotal role in promoting cancer cell growth, invasion, metastasis and angiogenesis. The identification of M2-like TAMs during tumor progression is an attractive approach for cancer therapy. In this study, we investigated the relevance of macrophage polarization and the antitumor effect of gefitinib in Lewis Lung cancer (LLC) in vitro and in vivo. Gefitinib at a concentration below 2.5 μmol/L did not cause significant growth inhibition on LLC and RAW 264...
October 12, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29021482/disseminated-cryptococcosis-with-marked-eosinophilia-in-a-postpartum-woman
#8
Tetsuya Yokoyama, Masako Kadowaki, Makoto Yoshida, Kunihiro Suzuki, Masashi Komori, Tomoaki Iwanaga
Disseminated cryptococcosis usually develops in immunosuppressed patients. A 33-year-old postpartum woman developed disseminated cryptococcosis with marked eosinophilia. She presented with a cough and a week-long fever. A computed tomography scan showed multiple pulmonary nodules randomly distributed. Eosinophils were observed to have increased in number in both her peripheral blood and bronchoalveolar lavage fluid. A transbronchial lung biopsy and cerebrospinal fluid specimens revealed findings consistent with cryptococcal infection...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29021460/a-case-of-dental-technicians-pneumoconiosis
#9
Masaki Okamoto, Masaki Tominaga, Shigeki Shimizu, Chiyo Yano, Ken Masuda, Masayuki Nakamura, Yoshiaki Zaizen, Takashi Nouno, Satoshi Sakamoto, Mitsuru Yokoyama, Tomotaka Kawayama, Tomoaki Hoshino
A 40-year-old female dental technician visited our hospital for the investigation of a chest X-ray abnormality. Chest computed tomography demonstrated centrilobular nodules and lung volume reduction, and her serum KL-6 level was elevated. A histological analysis of the specimens obtained on a surgical lung biopsy showed peribronchiolar fibrosis with pigmented macrophages and cholesterol clefts. An energy-dispersive X-ray analysis showed that these lung tissues contained some metals, including indium. The serum indium level was also elevated...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29018832/pharyngeal-myiasis-caused-by-sheep-botfly-oestrus-ovis-diptera-oestridae-larva-tabriz-east-azarbaijan-province-iran-a-case-report
#10
Teimour Hazratian, Ali Tagizadeh, Mohammad Chaichi, Madineh Abbasi
Myiasis is caused by the larvae of flies infesting animal or human tissues and organs. This report aims to present a case of pharyngeal myiasis caused by the larvae of Oestrus ovis (Diptera: Oestridae). A 55-yr old drug addict living in the Shahindeje village of Western Azerbaijan Province, northwestern Iran was referred to the Emam Reza Hospital in Tabriz, having a medical history of Chronic Obstructive Pulmonary Disease (COPD) and hospitalized due to respiratory distress, 20 days ago. He was intubated with a mechanical ventilator (MV) because of his respiratory distress condition...
March 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29017792/three-dimensional-printing-of-navigational-template-in-localization-of-pulmonary-nodule-a-pilot-study
#11
Lei Zhang, Mu Li, Zeyao Li, Xiermaimaiti Kedeer, Long Wang, Ziwen Fan, Chang Chen
BACKGROUND: Small pulmonary nodules are a common problem, especially with the wide implementation of lung cancer-screening program. This poses a great challenge to thoracic surgeons because of the difficulty of nodule localization. We recently built an efficient, customized navigational template using 3-dimensional (3D) printing technology to facilitate the procedure of lung nodule localization. This study aims to investigate its feasibility in clinical application. METHODS: Patients with peripheral lung nodules (<2 cm) were enrolled...
September 1, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29016305/real-time-polymerase-chain-reaction-assay-on-bronchoalveolar-lavage-an-alternative-method-for-diagnosing-chronic-pulmonary-schistosomiasis
#12
Federico Gobbi, Fabio Formenti, Francesca Perandin, Dora Buonfrate, Andrea Angheben, Simona Paiano, Zeno Bisoffi
Schistosomiasis causes mainly hepatic and genitourinary damage. Although lung nodules have been commonly described in acute phase, they are presumably underdiagnosed in chronic schistosomiasis. We previously reported a series of patients with chronic pulmonary schistosomiasis confirmed by the histological examination of the lung biopsies. In the present work, we retrospectively tested an in-house real-time polymerase chain reaction for Schistosoma (currently validated for diagnosis on stool and on urine) in the bronchoalveolar lavage (BAL) of a couple of those patients, and both resulted positive...
October 9, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28994206/the-computed-tomographic-tree-in-bud-pattern-characterization-and-comparison-with-radiographic-and-clinical-findings-in-36-cats
#13
Harriet Hahn, Swan Specchi, Isabelle Masseau, Carol Reinero, Ghita Benchekroun, Jaime Rechy, Gabriela Seiler, Pascaline Pey
In humans, a CT "tree-in-bud" pattern has been described as a characteristic of centrilobular bronchiolar dilation, with bronchiolar plugging by mucus, pus, or fluid. Aims of this retrospective, descriptive, multi-center study were to characterize the CT appearance of a "tree-in-bud" pattern in a group of cats, and compare this pattern with radiographic and clinical findings. Databases from four hospitals were searched during the period of January 2012 to September 2015 and cats with thoracic radiographs, thoracic CT scans and CT reports describing findings consistent with a "tree-in-bud" pattern were included...
October 9, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28992397/prognostic-significance-of-cavitary-lung-nodules-in-granulomatosis-with-polyangiitis-a-clinical-and-imaging-study-of-225-patients
#14
Bailey A Russell, Sindu Mohan, Rachandeep Chahal, Simon Carette, Christian Pagnoux
BACKGROUND: Granulomatosis with polyangiitis (GPA) is a systemic necrotizing vasculitis with pulmonary nodules as a common manifestation. Our study examined whether pulmonary nodules, and nodule type (solid versus cavitary), are associated with different disease manifestations and outcomes. METHODS: Demographic, clinical, biological, radiological data at diagnosis, during follow-up, and treatments of GPA patients followed at the Mount Sinai Hospital (Canada) vasculitis clinic were analyzed...
October 9, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28991558/lung-cancer-screening-why-when-and-how
#15
REVIEW
Florian J Fintelmann, Ravi V Gottumukkala, Shaunagh McDermott, Matthew D Gilman, Inga T Lennes, Jo-Anne O Shepard
This article explains the rationale of lung cancer screening with low-dose computed tomography and provides a practical approach to all relevant aspects of a lung cancer screening program. Imaging protocols, patient eligibility criteria, facility readiness, and reimbursement criteria are addressed step by step. Diagnostic criteria and Lung-RADS (Lung Computed Tomography Screening Reporting and Data System) nodule management pathways are illustrated with examples. Pearls and pitfalls for interpretation of lung cancer screening low-dose chest computed tomography are discussed...
November 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28988941/the-economic-impact-of-a-nurse-practitioner-directed-lung-cancer-screening-incidental-pulmonary-nodule-and-tobacco-cessation-clinic
#16
Christopher R Gilbert, Rob Ely, Joelle T Fathi, Brian E Louie, Candice L Wilshire, Hannah Modin, Ralph W Aye, Alexander S Farivar, Eric Vallières, Jed A Gorden
OBJECTIVE: Lung cancer screening programs have become increasingly prevalent within the United States after the National Lung Screening Trial results. We aimed to review the financial impact after programmatic implementation of Advanced Registered Nurse Practitioner-led programs of Lung Cancer Screening and Tobacco Related Diseases, Incidental Pulmonary Nodule Clinic, and Tobacco Cessation Services. METHODS: We reviewed revenue from 2013 to 2016 by our nurse practitioner-led program...
September 13, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28987666/a-comparative-analysis-of-dual-phase-dual-energy-ct-and-fdg-pet-ct-for-the-prediction-of-histopathological-invasiveness-of-non-small-cell-lung-cancer
#17
Rintaro Ito, Shingo Iwano, Hironori Shimamoto, Hiroyasu Umakoshi, Koji Kawaguchi, Shinji Ito, Katsuhiko Kato, Shinji Naganawa
PURPOSE: To compare dual-phase dual-energy CT (DE-CT) with FDG-PET/CT for predicting histopathological locoregional invasiveness of non-small cell lung cancers (NSCLCs). MATERIALS AND METHODS: We selected 63 consecutive patients with NSCLC lesions (37 males, 26 females; age range, 44-85 years; mean age, 69 years) who were evaluated preoperatively by both DE-CT and PET/CT at our institution. Postoperative microscopic invasiveness (lymphatic permeation, vascular invasion, and/or pleural involvement) was reviewed, and we defined locoregionally invasive tumors as those that had at least one positive finding of microscopic invasiveness...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28986629/incidental-perifissural-nodules-on-routine-chest-computed-tomography-lung-cancer-or-not
#18
Onno M Mets, Kaman Chung, Ernst Th Scholten, Wouter B Veldhuis, M Prokop, Bram van Ginneken, Cornelia M Schaefer-Prokop, Pim A de Jong
OBJECTIVES: Perifissural nodules (PFNs) are a common finding on chest CT, and are thought to represent non-malignant lesions. However, data outside a lung cancer-screening setting are currently lacking. METHODS: In a nested case-control design, out of a total cohort of 16,850 patients ≥ 40 years of age who underwent routine chest CT (2004-2012), 186 eligible subjects with incident lung cancer and 511 controls without were investigated. All non-calcified nodules ≥ 4 mm were semi-automatically annotated...
October 6, 2017: European Radiology
https://www.readbyqxmd.com/read/28984815/benefits-of-respiratory-gated-18f-fdg-pet-acquisition-in-lung-disease
#19
Pascal Bailly, Roger Bouzerar, Trevor Shields, Marc-Etienne Meyer, Joël Daouk
BACKGROUND: Fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) is a reliable imaging modality for the diagnosis of malignant lung nodules and to assess the latter's prognosis. However, physiological respiratory motion deteriorates PET images and thus decreases the technique's diagnostic and prognostic values. This issue can be overcome by applying respiratory gating to the F-FDG PET/CT acquisitions. PURPOSE: The aim of this study was to evaluate the ability of respiratory-gated F-FDG PET/CT to diagnose malignant lung nodules and to predict recurrence and patient survival...
October 3, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28983713/baseline-and-annual-repeat-rounds-of-screening-implications-for-optimal-regimens-of-screening
#20
Claudia I Henschke, Mary Salvatore, Matthew Cham, Charles A Powell, Larry DiFabrizio, Raja Flores, Andrew Kaufman, Corey Eber, Rowena Yip, David F Yankelevitz
OBJECTIVES: Differences in results of baseline and subsequent annual repeat rounds provide important information for optimising the regimen of screening. METHODS: A prospective cohort study of 65,374 was reviewed to examine the frequency/percentages of the largest noncalcified nodule (NCN), lung cancer cell types and Kaplan-Meier (K-M) survival rates, separately for baseline and annual rounds. RESULTS: Of 65,374 baseline screenings, NCNs were identified in 28,279 (43...
October 5, 2017: European Radiology
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