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Neonatal asphyxia

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https://www.readbyqxmd.com/read/29153684/impact-of-maternal-serum-uric-acid-on-perinatal-outcome-in-women-with-hypertensive-disorders-of-pregnancy-a-prospective-study
#1
Naina Kumar, Amit Kant Singh, Bhavya Maini
INTRODUCTION: Worldwide hypertensive disorder of pregnancy is major cause of maternal and perinatal morbidity, mortality. AIM: To study impact of maternal serum uric acid on perinatal outcome in women with hypertensive disorder of pregnancy. METHODOLOGY: Present study was conducted in Obstetrics and Gynecology Department of rural tertiary care centre of Northern India over seven months (October 2016-May 2017). Total 110 pregnant women >-34weeks with hypertensive disorder of pregnancy were divided into three groups; Gestational hypertension (n = 35), Pre-eclampsia (n = 49), Eclampsia (n = 26)...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29142568/echocardiographic-evaluation-of-cardiovascular-complications-after-birth-asphyxia-in-term-neonates
#2
Mohsen Shahidi, Ghodratollah Evazi, Abdorrahim Afkhamzadeh
Objectives: After birth asphyxia, a variety of hemodynamic disorders may be noted in the neonatal intensive care unit; these require appropriate recognition and management. The present study was designed to demonstrate the prevalence of heart complications amongst asphyxiated newborns. Methods: Through a cohort study, 29 asphyxiated term neonates were followed since birth until amelioration of pulmonary hypertension and compared with 31 well born neonates. Both groups were evaluated for their heart anatomy and hemodynamic with meticulous assessment through echocardiography...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29142564/clinical-effects-of-ganglioside-and-fructose-1-6-diphosphate-on-neonatal-heart-and-brain-injuries-after-asphyxia
#3
Xiaojing Zhu, Hongya Li, Congmin Zhang
Objective: To study the clinical effect of ganglioside (GM) and fructose-1, 6-diphosphate (FDP) on neonatal heart and brain injuries after asphyxia. Methods: Ninety-one neonates with asphyxia neonatal heart and brain injuries were randomly divided into an observation group and a control group. Both groups were given symptomatic treatment as soon as possible. On this basis, the observation group was given 200 mL of 5% glucose injection and 20 mg of GM and 250 mg/kg·d FDP by intravenous infusion...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29138115/active-forms-of-akt-and-erk-are-dominant-in-the-cerebral-cortex-of-newborn-pigs-that-are-unaffected-by-asphyxia
#4
Viktória Kovács, Valéria Tóth-Szűki, János Németh, Viktória Varga, Gábor Remzső, Ferenc Domoki
AIMS: Perinatal asphyxia (PA) often results in hypoxic-ischemic encephalopathy (HIE) in term neonates. Introduction of therapeutic hypothermia improved HIE outcome, but further neuroprotective therapies are still warranted. The present study sought to determine the feasibility of the activation of the cytoprotective PI-3-K/Akt and the MAPK/ERK signaling pathways in the subacute phase of HIE development in a translational newborn pig PA/HIE model. MAIN METHODS: Phosphorylated and total levels of Akt and ERK were determined by Western blotting in brain samples obtained from untreated naive, time control, and PA/HIE animals at 24-48h survival (n=3-3-6,respectively)...
November 11, 2017: Life Sciences
https://www.readbyqxmd.com/read/29137711/novel-free-radical-mediated-lipid-peroxidation-biomarkers-in-newborn-plasma
#5
Ángel Sánchez-Illana, Sudhin Thayyil, Paolo Montaldo, Dorothea Jenkins, Guillermo Quintás, Camille Oger, Jean-Marie Galano, Claire Vigor, Thierry Durand, Máximo Vento, Julia Kuligowski
Oxidative stress derived from perinatal asphyxia appears to be closely linked to neonatal brain damage and lipid peroxidation biomarkers have shown to provide predictive power of oxidative stress related pathologies in situations of hypoxia and reoxygenation in the newborn. The objective of this work was to develop and validate of a comprehensive liquid chromatography tandem mass spectrometry approach for the quantitative profiling of 28 isoprostanoids in newborn plasma samples covering a broad range of lipid peroxidation product classes...
December 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29137607/improved-referral-and-survival-of-newborns-after-scaling-up-of-intensive-care-in-suriname
#6
Rens Zonneveld, Natanael Holband, Anna Bertolini, Francesca Bardi, Neirude P A Lissone, Peter H Dijk, Frans B Plötz, Amadu Juliana
BACKGROUND: Scaling up neonatal care facilities in developing countries can improve survival of newborns. Recently, the only tertiary neonatal care facility in Suriname transitioned to a modern environment in which interventions to improve intensive care were performed. This study evaluates impact of this transition on referral pattern and outcomes of newborns. METHODS: A retrospective chart study amongst newborns admitted to the facility was performed and outcomes of newborns between two 9-month periods before and after the transition in March 2015 were compared...
November 14, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/29132457/-relationship-between-serum-25-oh-d-levels-at-birth-and-respiratory-distress-syndrome-in-preterm-infants
#7
Ren-Qiang Yu, Dao-Zhen Chen, Xiao-Qing Hao, Shi-Hong Jiang, Guang-Dong Fang, Qin Zhou
OBJECTIVE: To investigate the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels at birth and respiratory distress syndrome (RDS) in preterm infants. METHODS: This retrospective study recruited preterm infants with gestational age of below 34 weeks who were born between January 2014 and December 2016. These preterm infants were divided into two groups: RDS (n=72) and control (n=40). Clinical data of the two groups were collected, including gestational age, birth weight, gender, delivery mode, Apgar scores at 1 minute and 5 minutes, incidence of maternal gestational diabetes mellitus, and use of prenatal steroid hormone...
November 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29121418/the-panorama-of-cerebral-palsy-in-sweden-part-xii-shows-that-patterns-changed-in-the-birth-years-2007-2010
#8
K Himmelmann, P Uvebrant
AIM: This was the 12th population-based study to explore the epidemiology of cerebral palsy (CP) in western Sweden. METHODS: From 2007-2010 there were 104,713 live births in the area. We analysed the birth characteristics, aetiology and neuroimaging findings, calculated the prevalence and compared the results with previous study cohorts. RESULTS: CP was found in 205 children, corresponding to a crude prevalence of 1.96 per 1,000 live births...
November 9, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29119805/sociocultural-factors-affecting-uptake-of-home-based-neonatal-thermal-care-practices-in-africa-a-qualitative-review
#9
Wendy S Coalter, Sarah L Patterson
Neonatal hypothermia is a major contributor to neonatal mortality in sub-Saharan Africa, often as a comorbidity of severe infections, preterm births or asphyxia. Simple, cost-effective thermal care practices (TCPs) immediately at birth and in the post-natal period are recommended in the World Health Organization 'warm chain'. Current practices are suboptimal in the home in low-resource settings, where approximately half of neonatal deaths occur. Several databases (PubMed, OVID SP, Web of Science, The Cochrane Library and Google Scholar) were searched for original research on home-based TCPs...
June 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29095429/activation-of-toll-like-receptors-in-meconium-aspiration-syndrome
#10
V Anand, S Basu, S S Yadav, G Narayan, B D Bhatia, A Kumar
OBJECTIVE: Meconium aspiration syndrome (MAS) is a common cause of neonatal morbidity and mortality. Incomplete understanding of the pathogenesis of MAS has hindered the development of specific therapies. We hypothesized that activation of Toll-like receptors (TLRs) might play a role in the pathogenesis of MAS. The present study evaluated the expression of TLR 1, 4, 7, 8 and 9 in neonates with MAS. STUDY DESIGN: The study included 39 neonates with MAS and 17 healthy gestational age-matched neonates as controls...
November 2, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29092682/evaluation-of-dynamic-thiol-disulfide-homeostasis-in-very-low-birth-weighted-preterms
#11
Sezin Unal, Dilek Ulubas Isik, Ahmet Yagmur Bas, Sara Erol, İlter Arifoglu, Murat Alisik, Ozcan Erel, Nihal Demirel
BACKGROUND: Thiols are organic compounds containing sulfhydryl groups which exert antioxidant effects via dynamic thiol-disulfide homeostasis. The shift towards disulfides indicates the presence of oxidative environment. Thiol-disulfide homeostasis has not been evaluated in neonates. We aimed to evaluate dynamic thiol-disulfide homeostasis in preterm infants. METHODS: Preterm infants with birth weight less than 1500 grams (25-32 weeks of gestation) were included...
November 1, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29079904/neonatal-gastric-perforations-in-very-low-birth-weight-infants-a-single-center-experience-and-review-of-the-literature
#12
Aslan Babayigit, Seyithan Ozaydın, Merih Cetinkaya, Serdar Sander
PURPOSE: Gastric perforation is a rare condition with high mortality rates in preterm infants. The aim of this retrospective study was to define the risk factors and prognosis in very low birth weight (VLBW) infants with gastric perforations. METHODS: VLBW infants with a diagnosis of gastric perforation between 2012 and 2016 were included. The data including birth weight, gestational age, gender, risk factors, time and location of the perforation and prognosis were recorded...
October 27, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29077174/clinical-significance-of-dynamic-measurements-of-seric-tnf-%C3%AE-hmgbl-and-nse-levels-and-aeeg-monitoring-in-neonatal-asphyxia
#13
X-H Zhang, B-L Zhang, S-M Guo, P Wang, J-W Yang
OBJECTIVE: This study investigates the clinical value of monitoring blood levels of tumor necrosis factor-α (TNF-α), high mobility group protein Bl (HMGBl), and neuron-specific enolase (NSE), and examining an amplitude-integrated electroencephalogram (aEEG) for the diagnosis and short-term prognosis of brain damage caused by neonatal asphyxia. PATIENTS AND METHODS: Sixty full-term neonates born in Yidu Central Hospital from January to December 2015 were enrolled in the study...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29065732/choice-of-scheduled-cesarean-delivery-versus-trial-of-labor-for-advanced-maternal-age-primiparous-women
#14
Lina Salman, Anat Shmueli, Rony Chen, Eran Ashwal, Liran Hiersch, Yariv Yogev, Amir Aviram
OBJECTIVE: We aimed to evaluate perinatal outcomes of advanced maternal age (AMA) primiparous women seeking scheduled cesarean delivery (CD) versus a trial of labor (TOL). MATERIALS AND METHODS: This was a retrospective cohort study of primiparous women ≥ 40 years of age carrying a single fetus, who delivered at a tertiary, university-affiliated medical center (2007-2014). We compared perinatal outcomes of women who chose a scheduled CD with those who chose TOL...
October 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29058568/retention-and-use-of-newborn-resuscitation-skills-following-a-series-of-helping-babies-breathe-trainings-for-midwives-in-rural-ghana
#15
Darren Eblovi, Patricia Kelly, Georgina Afua, Sarah Agyapong, Siddhartha Dante, Matthew Pellerite
BACKGROUND: The Helping Babies Breathe (HBB) program teaches basic newborn resuscitation techniques to birth attendants in low-resource settings. Previous studies have demonstrated a decrease in mortality following training, mostly in large hospitals. However, low-volume clinics in rural regions with no physician immediately available likely experience a greater relative burden of newborn mortality. This study aimed to determine the impact of HBB trainings provided to rural Ghanaian midwives on their skills retention and on first 24 hour mortality of the newborns they serve...
2017: Global Health Action
https://www.readbyqxmd.com/read/29043436/cervical-dilation-balloon-combined-with-intravenous-drip-of-oxytocin-for-induction-of-term-labor-a-multicenter-clinical-trial
#16
Xueqin Wu, Chunxiang Wang, Yufang Li, Chunmei Ouyang, Jiaying Liao, Weibin Cai, Yilei Zhong, Jianping Zhang, Hui Chen
OBJECTIVE: This study aimed to investigate the effectiveness and safety of a method combining double-balloon catheter for cervical ripening and intravenous drip of oxytocin on the induction of term labor, providing the reference for clinical safety. METHODS: A total of 120 pregnant women with a gestation between 37(+0) and  41(+6) weeks, indications of labor induction, singleton pregnancy with cephalic presentation were enrolled. The patients were divided into the research group receiving cervical dilation balloon combined with intravenous drip of oxytocin and the control group receiving an intravenous drip of oxytocin at a concentration of 0...
October 17, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29030024/neurodevelopmental-outcomes-at-3-years-old-for-infants-with-birth-weights-under-500%C3%A2-g
#17
Syunsuke Nagara, Masanori Kouwaki, Takao Togawa, Tokio Sugiura, Mayumi Okada, Norihisa Koyama
BACKGROUND: Marked improvements have been achieved in the survival of extremely low birth weight infants, but survival rates and prognoses of extremely small infants with birth weights ≤500 g remain poor. The aim of this study was to clarify long-term outcomes for surviving infants with birth weights ≤500 g. METHODS: The study population comprised fetuses of gestational age ≥22 weeks, expected live- or stillbirth weight ≤500 g, and birth date between 2003 and 2012...
September 21, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29016584/morbidities-and-outcome-of-a-neonatal-intensive-care-in-western-nepal
#18
Sudhir Adhikari, Kalipatanam Seshagiri Rao, Ganesh B K, Namraj Bahadur
BACKGROUND: Neonatal mortality rate of developing countries is declining over decades. In the recent years increasing number of preterm and high risk neonates have facilities for tertiary care treatment. The aim of the study was to assess the morbidities and outcome of neonatal intensive care admissions. METHODS: It was a retrospective observational study carried out in neonatal intensive care unit of the Manipal Teaching Hospital, Pokhara, Nepal from January 2014 to December 2015...
September 8, 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28993332/amikacin-pharmacokinetics-to-optimize-dosing-in-neonates-with-perinatal-asphyxia-treated-with-hypothermia
#19
Sinziana Cristea, Anne Smits, Aida Kulo, Catherijne A J Knibbe, Mirjam van Weissenbruch, Elke H J Krekels, Karel Allegaert
Aminoglycosides pharmacokinetics (PK) is expected to change in neonates with perinatal asphyxia treated with therapeutic hypothermia (PATH). Several amikacin dosing guidelines have been proposed to treat neonates with (suspected) septicemia, however, none provide adjustments in the case of PATH. Therefore, we aimed to quantify the differences in amikacin PK between neonates with and without PATH to propose suitable dosing recommendations.Based on amikacin therapeutic drug monitoring data collected retrospectively from neonates with PATH, combined with a published dataset, we assessed the impact of PATH on amikacin PK using population modelling...
October 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28969690/the-quality-of-medical-death-certification-of-cause-of-death-in-hospitals-in-rural-bangladesh-impact-of-introducing-the-international-form-of-medical-certificate-of-cause-of-death
#20
Riley H Hazard, Hafizur Rahman Chowdhury, Tim Adair, Adnan Ansar, A M Quaiyum Rahman, Saidul Alam, Nurul Alam, Rasika Rampatige, Peter Kim Streatfield, Ian Douglas Riley, Alan D Lopez
BACKGROUND: Accurate and timely data on cause of death are critically important for guiding health programs and policies. Deaths certified by doctors are implicitly considered to be reliable and accurate, yet the quality of information provided in the international Medical Certificate of Cause of Death (MCCD) usually varies according to the personnel involved in certification, the diagnostic capacity of the hospital, and the category of hospitals. There are no published studies that have analysed how certifying doctors in Bangladesh adhere to international rules when completing the MCCD or have assessed the quality of clinical record keeping...
October 2, 2017: BMC Health Services Research
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