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Fluid dynamics of the heart

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https://www.readbyqxmd.com/read/29896107/construction-and-validation-of-subject-specific-biventricular-finite-element-models-of-healthy-and-failing-swine-hearts-from-high-resolution-dt-mri
#1
Kevin L Sack, Eric Aliotta, Daniel B Ennis, Jenny S Choy, Ghassan S Kassab, Julius M Guccione, Thomas Franz
Predictive computational modeling has revolutionized classical engineering disciplines and is in the process of transforming cardiovascular research. This is particularly relevant for investigating emergent therapies for heart failure, which remains a leading cause of death globally. The creation of subject-specific biventricular computational cardiac models has been a long-term endeavor within the biomedical engineering community. Using high resolution (0.3 × 0.3 × 0.8 mm) ex vivo data, we constructed a precise fully subject-specific biventricular finite-element model of healthy and failing swine hearts...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29892995/evaluating-the-roles-of-detailed-endocardial-structures-on-right-ventricular-haemodynamics-by-means-of-cfd-simulations
#2
Federica Sacco, Bruno Paun, Oriol Lehmkuhl, Tinen L Iles, Paul A Iaizzo, Guillaume Houzeaux, Mariano Vázquez, Constantine Butakoff, Jazmin Aguado-Sierra
Computational modelling plays an important role in right ventricular (RV) haemodynamic analysis. However, current approaches employ smoothed ventricular anatomies. The aim of this study is to characterise RV haemodynamics including detailed endocardial structures like trabeculae, moderator band and papillary muscles (PMs). Four paired detailed and smoothed RV endocardium models (two male and two female) were reconstructed from ex-vivo human hearts high-resolution magnetic resonance images (MRI). Detailed models include structures with ≥1 mm2 cross-sectional area...
June 11, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29845751/in-vivo-optical-imaging-of-the-viable-epidermis-around-the-nailfold-capillaries-for-the-assessment-of-heart-failure-severity-in-humans
#3
Evgeny A Shirshin, Yury I Gurfinkel, Simon T Matskeplishvili, Maria L Sasonko, Nikolai P Omelyanenko, Boris P Yakimov, Juergen Lademann, Maxim E Darvin
Heart failure is among the socially significant diseases, involving over 2% of the adult population in the developed countries. Diagnostics of the HF severity remains complicated due to the absence of specific symptoms and objective criteria. Here we present an indicator of the HF severity based on the imaging tissue parameters around the nailfold capillaries. High resolution nailfold video capillaroscopy was performed to determine the perivascular zone (PZ) size around nailfold capillaries, and two-photon tomography with fluorescence lifetime imaging was used to investigate PZ composition...
May 29, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29844073/energetics-of-blood-flow-in-cardiovascular-disease-concept-and-clinical-implications-of-adverse-energetics-in-patients-with-a-fontan-circulation
#4
REVIEW
Friso M Rijnberg, Mark G Hazekamp, Jolanda J Wentzel, Patrick J H de Koning, Jos J M Westenberg, Monique R M Jongbloed, Nico A Blom, Arno A W Roest
Visualization and quantification of the adverse effects of distorted blood flow are important emerging fields in cardiology. Abnormal blood flow patterns can be seen in various cardiovascular diseases and are associated with increased energy loss. These adverse energetics can be measured and quantified using 3-dimensional blood flow data, derived from computational fluid dynamics and 4-dimensional flow magnetic resonance imaging, and provide new, promising hemodynamic markers. In patients with palliated single-ventricular heart defects, the Fontan circulation passively directs systemic venous return to the pulmonary circulation in the absence of a functional subpulmonary ventricle...
May 29, 2018: Circulation
https://www.readbyqxmd.com/read/29843227/impact-of-plasma-viscosity-on-microcirculatory-flow-after-traumatic-haemorrhagic-shock-a-prospective-observational-study
#5
David N Naumann, Jon Hazeldine, Jon Bishop, Mark J Midwinter, Paul Harrison, Gerard Nash, Sam D Hutchings
BACKGROUND: Preclinical studies report that higher plasma viscosity improves microcirculatory flow after haemorrhagic shock and resuscitation, but no clinical study has tested this hypothesis. OBJECTIVE: We investigated the relationship between plasma viscosity and sublingual microcirculatory flow in patients during resuscitation for traumatic haemorrhagic shock (THS). METHODS: Sublingual video-microscopy was performed for 20 trauma patients with THS as soon as feasible in hospital, and then at 24 h and 48 h...
May 19, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29799313/fluid-dynamics-inside-the-brain-barrier-current-concept-of-interstitial-flow-glymphatic-flow-and-cerebrospinal-fluid-circulation-in-the-brain
#6
Tsutomu Nakada, Ingrid L Kwee
The discovery of the water specific channel, aquaporin, and abundant expression of its isoform, aquaporin-4 (AQP-4), on astrocyte endfeet brought about significant advancements in the understanding of brain fluid dynamics. The brain is protected by barriers preventing free access of systemic fluid. The same barrier system, however, also isolates brain interstitial fluid from the hydro-dynamic effect of the systemic circulation. The systolic force of the heart, an essential factor for proper systemic interstitial fluid circulation, cannot be propagated to the interstitial fluid compartment of the brain...
May 1, 2018: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/29787689/patient-specific-multiscale-computational-fluid-dynamics-assessment-of-embolization-rates-in-the-hybrid-norwood-effects-of-size-and-placement-of-the-reverse-blalock-taussig-shunt
#7
Ray Otto Prather, John Seligson, Marcus Ni, Eduardo Divo, Alain Kassab, William DeCampli
The hybrid Norwood operation is performed to treat hypoplastic left heart syndrome. Distal arch obstruction may compromise flow to the brain. In a variant of this procedure, a synthetic graft (RBTS) is placed between the pulmonary trunk and innominate artery to improve upper torso blood flow. Thrombi originating in the graft may embolize to the brain. In this study we used computational fluid dynamics (CFD) and particle tracking to investigate the patterns of particle embolization as a function of the anatomic position of the RBTS...
May 22, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29767196/strategies-for-directing-cells-into-building-functional-hearts-and-parts
#8
REVIEW
Mahboubeh Jafarkhani, Zeinab Salehi, Reza Kowsari-Esfahan, Mohammad Ali Shokrgozar, M Rezaa Mohammadi, Jayakumar Rajadas, Masoud Mozafari
The increasing population of patients with heart disease and the limited availability of organs for transplantation have encouraged multiple strategies to fabricate healthy implantable cardiac tissues. One of the main challenges in cardiac tissue engineering is to direct cell behaviors to form functional three-dimensional (3D) biomimetic constructs. This article provides a brief review on various cell sources used in cardiac tissue engineering and highlights the effect of scaffold-based signals such as topographical and biochemical cues and stiffness...
May 16, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29761422/computational-pre-surgical-planning-of-arterial-patch-reconstruction-parametric-limits-and-in-vitro-validation
#9
S Samaneh Lashkarinia, Senol Piskin, Tijen A Bozkaya, Ece Salihoglu, Can Yerebakan, Kerem Pekkan
Surgical treatment of congenital heart disease (CHD) involves complex vascular reconstructions utilizing artificial and native surgical materials. A successful surgical reconstruction achieves an optimal hemodynamic profile through the graft in spite of the complex post-operative vessel growth pattern and the altered pressure loading. This paper proposes a new in silico patient-specific pre-surgical planning framework for patch reconstruction and investigates its computational feasibility. The proposed protocol is applied to the patch repair of main pulmonary artery (MPA) stenosis in the Tetralogy of Fallot CHD template...
May 14, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29760665/left-ventricular-trabeculations-decrease-the-wall-shear-stress-and-increase-the-intra-ventricular-pressure-drop-in-cfd-simulations
#10
Federica Sacco, Bruno Paun, Oriol Lehmkuhl, Tinen L Iles, Paul A Iaizzo, Guillaume Houzeaux, Mariano Vázquez, Constantine Butakoff, Jazmin Aguado-Sierra
The aim of the present study is to characterize the hemodynamics of left ventricular (LV) geometries to examine the impact of trabeculae and papillary muscles (PMs) on blood flow using high performance computing (HPC). Five pairs of detailed and smoothed LV endocardium models were reconstructed from high-resolution magnetic resonance images (MRI) of ex-vivo human hearts. The detailed model of one LV pair is characterized only by the PMs and few big trabeculae, to represent state of art level of endocardial detail...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29735315/accuracy-and-precision-of-a-plane-wave-vector-flow-imaging-method-in-the-healthy-carotid-artery
#11
Jonas Jensen, Carlos Armando Villagómez Hoyos, Marie Sand Traberg, Jacob Bjerring Olesen, Borislav Gueorguiev Tomov, Ramin Moshavegh, Simon Holbek, Matthias Bo Stuart, Caroline Ewertsen, Kristoffer Lindskov Hansen, Carsten Thomsen, Michael Bachmann Nielsen, Jørgen Arendt Jensen
The objective of the study described here was to investigate the accuracy and precision of a plane wave 2-D vector flow imaging (VFI) method in laminar and complex blood flow conditions in the healthy carotid artery. The approach was to study (i) the accuracy for complex flow by comparing the velocity field from a computational fluid dynamics (CFD) simulation to VFI estimates obtained from the scan of an anthropomorphic flow phantom and from an in vivo scan; (ii) the accuracy for laminar unidirectional flow in vivo by comparing peak systolic velocities from VFI with magnetic resonance angiography (MRA); (iii) the precision of VFI estimation in vivo at several evaluation points in the vessels...
May 4, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29735263/an-anisotropic-constitutive-model-for-immersogeometric-fluid-structure-interaction-analysis-of-bioprosthetic-heart-valves
#12
Michael C H Wu, Rana Zakerzadeh, David Kamensky, Josef Kiendl, Michael S Sacks, Ming-Chen Hsu
This paper considers an anisotropic hyperelastic soft tissue model, originally proposed for native valve tissue and referred to herein as the Lee-Sacks model, in an isogeometric thin shell analysis framework that can be readily combined with immersogeometric fluid-structure interaction (FSI) analysis for high-fidelity simulations of bioprosthetic heart valves (BHVs) interacting with blood flow. We find that the Lee-Sacks model is well-suited to reproduce the anisotropic stress-strain behavior of the cross-linked bovine pericardial tissues that are commonly used in BHVs...
April 12, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29724722/coronary-artery-remodeling-and-fibrosis-with-continuous-flow-left-ventricular-assist-device-support
#13
Amrut V Ambardekar, Mary C M Weiser-Evans, Marcella Li, Suneet N Purohit, Muhammad Aftab, T Brett Reece, Karen S Moulton
BACKGROUND: Coronary artery fluid dynamics may be altered because of the nonphysiological flow seen in continuous-flow left ventricular assist devices (CF-LVADs). Our aim was to study the structure and composition of coronary vessels after CF-LVAD. METHODS AND RESULTS: Coronary arteries were collected from patients with heart failure (HF) at the time of transplantation, of whom 15 were supported with a CF-LVAD before transplant (HF+LVAD group) and 9 were not (HF non-LVAD group)...
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29720173/clinical-validation-and-assessment-of-aortic-hemodynamics-using-computational-fluid-dynamics-simulations-from-computed-tomography-angiography
#14
Yulei Zhu, Rui Chen, Yu-Hsiang Juan, He Li, Jingjing Wang, Zhuliang Yu, Hui Liu
BACKGROUND: Hemodynamic information including peak systolic pressure (PSP) and peak systolic velocity (PSV) carry an important role in evaluation and diagnosis of congenital heart disease (CHD). Since MDCTA cannot evaluate hemodynamic information directly, the aim of this study is to provide a noninvasive method based on a computational fluid dynamics (CFD) model, derived from multi-detector computed tomography angiography (MDCTA) raw data, to analyze the aortic hemodynamics in infants with CHD, and validate these results against echocardiography and cardiac catheter measurements...
May 2, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29713288/3d-fluid-structure-interaction-simulation-of-aortic-valves-using-a-unified-continuum-ale-fem-model
#15
Jeannette H Spühler, Johan Jansson, Niclas Jansson, Johan Hoffman
Due to advances in medical imaging, computational fluid dynamics algorithms and high performance computing, computer simulation is developing into an important tool for understanding the relationship between cardiovascular diseases and intraventricular blood flow. The field of cardiac flow simulation is challenging and highly interdisciplinary. We apply a computational framework for automated solutions of partial differential equations using Finite Element Methods where any mathematical description directly can be translated to code...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29704185/the-effect-of-heated-co-2-insufflation-in-minimising-surgical-wound-contamination-during-open-surgery
#16
Monika Baumann, John E Cater
The primary source of infections in open surgeries has been found to be bacteria and viruses carried into the surgical wound on the surfaces of skin particles shed by patients and surgical staff. In open cardiac surgeries, insufflation of the wound with carbon dioxide is used to limit the quantity of air able to enter into the heart, avoiding air embolisms when the heart is restarted. This surgical technique has been evaluated as a method of limiting the number of skin particles able to enter into the wound, using computational fluid dynamics (CFD) simulations and experimental testing...
April 27, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29677037/small-left-ventricular-size-is-an-independent-risk-factor-for-ventricular-assist-device-thrombosis
#17
Venkat Keshav Chivukula, Jennifer A Beckman, Anthony R Prisco, Shin Lin, Todd F Dardas, Richard K Cheng, Stephen D Farris, Jason W Smith, Nahush A Mokadam, Claudius Mahr, Alberto Aliseda
The prevalence of ventricular assist device (VAD) therapy has continued to increase due to a stagnant donor supply and growing advanced heart failure (HF) population. We hypothesize that left ventricular (LV) size strongly influences biocompatibility and risk of thrombosis. Unsteady computational fluid dynamics (CFD) was used in conjunction with patient-derived computational modeling and virtual surgery with a standard, apically implanted inflow cannula. A dual-focus approach of evaluating thrombogenicity was employed: platelet-based metrics to characterize the platelet environment and flow-based metrics to investigate hemodynamics...
April 18, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29675697/computational-fluid-dynamics-assessment-associated-with-transcatheter-heart-valve-prostheses-a-position-paper-of-the-iso-working-group
#18
REVIEW
Zhenglun Alan Wei, Simon Johannes Sonntag, Milan Toma, Shelly Singh-Gryzbon, Wei Sun
The governing international standard for the development of prosthetic heart valves is International Organization for Standardization (ISO) 5840. This standard requires the assessment of the thrombus potential of transcatheter heart valve substitutes using an integrated thrombus evaluation. Besides experimental flow field assessment and ex vivo flow testing, computational fluid dynamics is a critical component of this integrated approach. This position paper is intended to provide and discuss best practices for the setup of a computational model, numerical solving, post-processing, data evaluation and reporting, as it relates to transcatheter heart valve substitutes...
April 19, 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29666072/left-ventricular-assist-device-inflow-cannula-angle-and-thrombosis-risk
#19
Venkat Keshav Chivukula, Jennifer A Beckman, Anthony R Prisco, Todd Dardas, Shin Lin, Jason W Smith, Nahush A Mokadam, Alberto Aliseda, Claudius Mahr
BACKGROUND: As heart failure prevalence continues to increase in the setting of a static donor supply, left ventricular assist device (LVAD) therapy for end-stage heart failure continues to grow. Anecdotal evidence suggests that malalignment of the LVAD inflow cannula may increase thrombosis risk, but this effect has not been explored mechanistically or quantified statistically. Our objective is to elucidate the impact of surgical angulation of the inflow cannula on thrombogenicity. METHODS AND RESULTS: Unsteady computational fluid dynamics is used in conjunction with computational modeling and virtual surgery to model flow through the left ventricle for 5 different inflow cannula angulations...
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29617784/the-influence-of-different-inflow-configurations-on-computational-fluid-dynamics-in-a-novel-three-leaflet-mechanical-heart-valve-prosthesis
#20
Hans-Hinrich Sievers, Kathrin Schubert, Ashkan Jamali, Michael Scharfschwerdt
OBJECTIVES: A novel mechanical heart valve was developed with a special focus on avoiding anticoagulation. Computational fluid dynamics were used for the research design. Here, the effect of different anatomical inflow geometries on flow characteristics is evaluated. METHODS: Flow and pressure simulations were performed on a novel 3-leaflet mechanical heart valve in a fully open position at 2 flow rates related to the peak and end-systolic flow. The computational fluid dynamics model was designed according to 4 different (1 cylindrical, 3 conical with increasing diameter) anatomical configurations of the left ventricular outflow tract derived from an inverse heart model...
March 30, 2018: Interactive Cardiovascular and Thoracic Surgery
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