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EDITORIAL
Mayank Kapoor, Amit Sehrawat, Jayalingappa Karthik, Deepak Sundriyal
This editorial will focus on tumor immunity and the factors that alter the tumor immune micro-environment. The role of tumor infiltrating lymphocytes (TILs) will also be discussed in detail, including the types, mechanism of action, and role. Gastric cancer (GC) often presents in the advanced stage and has various factors predicting the outcomes. The interplay of these factors and their correlation with the TILs is discussed. A literature review revealed high intra-tumoral TILs associated with higher grade, HER2-, and Helicobacter pylori negativity...
April 24, 2024: World Journal of Clinical Oncology
#22
JOURNAL ARTICLE
Ioana Alexandra Cardos, Catalina Danila, Timea Claudia Ghitea, Ovidiu Pop, Andrei Pascalau, Simona Cavalu
BACKGROUND/AIM: H. pylori infection can promote a systemic inflammatory syndrome, eventually leading to intestinal metaplasia and gastric cancer. The aim of our study was to investigate the possible association between dyslipidemia and histopathological features of H. pylori gastritis. PATIENTS AND METHODS: An observational, retrospective study was conducted over the period 2017-2022 on symptomatic patients with a positive rapid urease test. A total of 121 patients who underwent upper gastrointestinal endoscopy with stomach biopsy were enrolled in this study...
2024: In Vivo
#23
JOURNAL ARTICLE
Xin Guan, Jing Ning, Weiwei Fu, Ye Wang, Jing Zhang, Shigang Ding
BACKGROUND: Helicobacter pylori infection is one of the main causes of gastric cancer. thioredoxin-1 (Trx1) and arginase (RocF) expressed by H. pylori were found to be closely related to its pathogenicity. However, whether Trx1 and RocF can be used in clinical screening of highly pathogenic H. pylori and the pathogenesis of trx1 high expressing H. pylori remain still unknown. MATERIALS AND METHODS: We investigated the expression level of H. pylori trx1 and H. pylori rocF in human gastric antrum tissues using reverse transcription and quantitative real-time PCR (RT-qPCR) and clarified the clinical application value of trx1 and rocF for screening highly pathogenic H...
2024: Helicobacter
#24
REVIEW
Deekshitha Alla, Dhruv Jayeshkumar Shah, Muneesh Seepana, Rishabh Baskara Salian, Sai Santhosha Mrudula Alla, Midhun Krishna Mohanan, Mert Sabıroğlu, Mohan Sai Sunith Vegesna, Aradhya Singh, Srajan Gupta, Shushrutha Shivalingappa Rekha
Objective. Commonly recommended drugs for adults and children include proton pump inhibitors (PPIs), proven effective for treating peptic diseases like stomach ulcers, GERD, and Helicobacter pylori infections in children over 1-year-old. Yet, prolonged PPI use carries higher risks of adverse reactions, prompting this study's analysis. Methods. We have performed a systematic review of 30 articles, which include a total of 762 505 pediatric patients. Results. Adverse effects were encountered in 6.98% of the population...
2024: Global Pediatric Health
#25
JOURNAL ARTICLE
Jose M Huguet, Luis Ferrer-Barceló, Patrícia Suárez, Susana Barcelo-Cerda, Javier Sempere, Ilaria Maria Saracino, Giulia Fiorini, Dino Vaira, Ángeles Pérez-Aísa, Laimas Jonaitis, Bojan Tepes, M Castro-Fernandez, Manuel Pabón-Carrasco, Alma Keco-Huerga, Irina Voynovan, Alfredo J Lucendo, Ángel Lanas, Samuel J Martínez-Domínguez, Enrique Alfaro Almajano, Luis Rodrigo, Ludmila Vologzanina, Dmitry S Bordin, Antonio Gasbarrini, Gülüstan Babayeva, Frode Lerang, Mārcis Leja, Juozas Kupčinskas, Theodore Rokkas, Ricardo Marcos-Pinto, Antonio Meštrović, Oleksiy Gridnyev, Perminder S Phull, Sinead M Smith, Doron Boltin, György Miklós Buzás, Jan Kral, Halis Şimşek, Tamara Matysiak-Budnik, Vladimir Milivojevic, Wojciech Marlicz, Marino Venerito, Lyudmila Boyanova, Michael Doulberis, Lisette G Capelle, Anna Cano-Català, Leticia Moreira, Olga P Nyssen, Francis Mégraud, Colm O'Morain, Javier P Gisbert
BACKGROUND: Adherence to Helicobacter pylori (H. pylori) eradication treatment is a cornerstone for achieving adequate treatment efficacy. OBJECTIVE: To determine which factors influence compliance with treatment. METHODS: A systematic prospective non-interventional registry (Hp-EuReg) of the clinical practice of European gastroenterologists. Compliance was considered adequate if ≥90% drug intake. Data were collected until September 2021 using the AEG-REDCap e-CRF and were subjected to quality control...
April 29, 2024: United European Gastroenterology Journal
#26
JOURNAL ARTICLE
V Sánchez-Quezada, N Velázquez-Guadarrama, S Mendoza-Elizalde, M Hernandez-Iturriaga, P Vázquez Landaverde, G Loarca-Piña
ETHNOPHARMACOLOGICAL RELEVANCE: In ancient Mexican cultures, the Persea americana Mill seed has been used against gastrointestinal diseases, due to high concentrations of bioactive compounds. According to Traditional Mexican Medicine, P. americana seed aqueous infusion is used against roundworms, intestinal worms, parasites, and gastrointestinal problems, in a dose taken over three or four days. In addition, Mexican Society of Natural History indicates the traditional use of P. americana seed powder as an antiparasitic, and antibacterial (MTM, 2009)...
April 27, 2024: Journal of Ethnopharmacology
#27
JOURNAL ARTICLE
Lih-Lih Ong, Hau-Ming Jan, Hong-Hanh Thi Le, Tsai-Chen Yang, Chou-Yu Kuo, Ai-Feng Feng, Kwok-Kong Tony Mong, Chun-Hung Lin
BACKGROUND: Helicobacter pylori, the main cause of various gastric diseases, infects approximately half of the human population. This pathogen is auxotrophic for cholesterol which it converts to various cholesteryl α-glucoside derivatives, including cholesteryl 6'-acyl α-glucoside (CAG). Since the related biosynthetic enzymes can be translocated to the host cells, the acyl chain of CAG likely comes from its precursor phosphatidylethanolamine (PE) in the host membranes. This work aims at examining how the acyl chain of CAG and PE inhibits the membrane functions, especially bacterial adhesion...
April 29, 2024: Journal of Biomedical Science
#28
JOURNAL ARTICLE
Zhenyu Jiang, Boning Deng, Yaqi Zhang, Ye Li, Zhijun Yu, Haiying Deng, Yajun Chen
OBJECTIVES: To compare the efficacy and safety of seven Chinese patent medicines (CPMs) combined with conventional triple/quadruple therapy (T/Q) for Helicobacter pylori -positive peptic ulcers. DESIGN: A systematic review and network meta-analysis. DATA SOURCES: China National Knowledge Infrastructure, VIP database, Wanfang database, ScienceDirect, EBSCO, EMBASE, Web of Science, Cochrane Library and PubMed were searched through 1 June 2022...
April 29, 2024: BMJ Open
#29
JOURNAL ARTICLE
Andrés Sánchez-Caraballo, Valentina García-Solano, Sonia Karina González-Rangel, Valeria Grattz-Lamadrid, Marlon Munera-Gomez
INTRODUCTION: Cardiovascular diseases are the result of genetic and environmental interaction that conditions the integrity of the heart and blood vessels. Risk factors include infections. The inflammatory response against the infectious agent is a trigger of autoimmune cardiovascular diseases due to the similarity between the pathogen proteins and human antigens, since the immune response can present cross-reactivity caused by molecular mimicry. METHODS: We performed a search for pathogens involved in autoimmune heart diseases and autoantigens 9 associated with these diseases in the Pubmed and Google Scholar search engines...
February 1, 2024: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
#30
JOURNAL ARTICLE
Sara R Druffner, Shrinidhi Venkateshwaraprabu, Stuti Khadka, Benjamin C Duncan, Maeve T Morris, Emel Sen-Kilic, Fredrick H Damron, George W Liechti, Jonathan T Busada
UNLABELLED: Gastric cancer is the fifth most diagnosed cancer in the world. Infection by the bacteria Helicobacter pylori (HP) is associated with approximately 75% of gastric cancer cases. HP infection induces chronic gastric inflammation, damaging the stomach and fostering carcinogenesis. Most mechanistic studies on gastric cancer initiation are performed in mice and utilize either mouse-adapted strains of HP or the natural mouse pathogen Helicobacter felis (HF). Here, we identified the differences in gastric inflammation, atrophy, and metaplasia associated with HP and HF infection in mice...
April 29, 2024: Microbiology Spectrum
#31
RANDOMIZED CONTROLLED TRIAL
Jing Chen, Yan Zhang, Hanchen Min, Junli Zhi, Shuyun Ma, Hongxia Dong, Jingshuang Yan, Xiaoyan Chi, Xiaomei Zhang, Yunsheng Yang
BACKGROUND: A novel regimen with high-dose dual therapy (HDDT) has emerged, but its impact on the gut microbiota is not well understood. This study aimed to evaluate the impact of HDDT on the gut microbiota and compare it with that of bismuth quadruple therapy (BQT). METHODS: We enrolled outpatients (18-70 years) diagnosed with Helicobacter pylori infection by either histology or a positive 13 C-urea breath test (13 C-UBT) and randomly assigned to either the BQT or HDDT group...
2024: Helicobacter
#32
JOURNAL ARTICLE
Radha Kumari, Manoj Kumar, Kumari Seema, Abhay Kumar, Manju Boipai, Manohar Lal Prasad, Ashok K Sharma
Background Helicobacter pylori is one of the most common bacterial pathogens in humans. It is a microaerophilic bacteria with multiple unipolar flagella. It is associated with the development of various lesions like chronic gastritis, gastric ulcers, adenocarcinoma, and mucosa-associated lymphomas. The aim of this study was a comparative evaluation of the rapid urease test (RUT) and polymerase chain reaction (PCR) in gastric biopsy and aspirates for the detection of H. pylori infection and to further determine the sensitivity and specificity of RUT and PCR...
March 2024: Curēus
#33
EDITORIAL
Osamu Toyoshima, Toshihiro Nishizawa, Keisuke Hata
Olympus Corporation developed texture and color enhancement imaging (TXI) as a novel image-enhancing endoscopic technique. This topic highlights a series of hot-topic articles that investigated the efficacy of TXI for gastrointestinal disease identification in the clinical setting. A randomized controlled trial demonstrated improvements in the colorectal adenoma detection rate (ADR) and the mean number of adenomas per procedure (MAP) of TXI compared with those of white-light imaging (WLI) observation (58.7% vs 42...
April 14, 2024: World Journal of Gastroenterology: WJG
#34
JOURNAL ARTICLE
David Y Graham
For decades, antimicrobial therapy for Helicobacter pylori infection has been given empirically, and the results of therapy (success or failure) have either not been confirmed or when confirmed have not been used to modify prescribing behavior. These practices coupled with increasing antibiotic resistance have resulted in low cure rates overall. Susceptibility testing for H pylori has increasingly become available, especially in the United States. Availability of susceptibility-based therapy has encouraged adoption of the principles of antimicrobial stewardship for H pylori infection (eg, limiting antibiotic choice to antibiotics for which the infection is susceptible given at optimal doses, formulations, frequency of administration, and duration)...
March 2024: Gastroenterology & Hepatology
#35
RANDOMIZED CONTROLLED TRIAL
Aurelien Amiot, Jérémy Hacoon, Frederic Heluwaert, François Mion, Dominique Lamarque, Driffa Moussata, Maroua Mimouni, Jean-Charles Delchier, Isabelle Durand-Zaleski, Etienne Audureau, Sylvie Bastuji-Garin
BACKGROUND: The systematic use of susceptibility testing and tailored first-line treatment for Helicobacter pylori eradication has yet to be established. AIM: To compare 14-day tailored PCR-guided triple therapy to 14-day non-Bismuth concomitant quadruple therapy for first-line Helicobacter pylori eradication. PATIENTS AND METHODS: We performed a multicenter, parallel-group, randomized noninferiority controlled trial. Naive adult patients with Helicobacter pylori infection were treated with 14-day tailored PCR-guided triple therapy (esomeprazole 40 mg and amoxicillin 1000 mg b...
2024: Helicobacter
#36
MULTICENTER STUDY
Anja Šterbenc, Uroš Godnov, Polona Maver Vodičar, Saša Simčič, Samo Jeverica, Živa Zaletel, Pia Homan, Eva Miler Mojškerc, Matjaž Homan
BACKGROUND: Helicobacter pylori (H. pylori) infection is primarily acquired in childhood and is notably influenced by socioeconomic variances across different geographical regions. The aim of this study is to assess the prevalence of H. pylori infection in Slovenian children and to identify potential risk factors that facilitate the infection. MATERIALS AND METHODS: Between 2019 and 2022, we conducted a multi-center prospective cross-sectional study among healthy children residing in three different administrative regions in Slovenia...
2024: Helicobacter
#37
JOURNAL ARTICLE
Sintayehu Fekadu, Seyife Kibru, Sisay Tesfaye, Tariku Egeno, Alemu Tamiso, Hizkel Engiso, Serawit Deyno
BACKGROUND: Dyspepsia is a common gastrointestinal illness sometimes associated with Helicobacter pylori (H. pylori) infection. Screening and eradicating the bacterium reduces the risk of infection-related complications. The aim of this study was to determine the magnitude of H. pylori infection among dyspeptic patients and the effectiveness of triple eradication therapy at hospitals in Hawassa city, Ethiopia. RESULTS: The prevalence of H. pylori infection was 48...
April 27, 2024: Gut Pathogens
#38
JOURNAL ARTICLE
Lin Chen, Yue Zhu, Yilin Huang, Keqing Shen, Liying Chen
PURPOSE: Helicobacter pylori (H. pylori) infection has been reported to be associated with multiple metabolic diseases. However, the connection between H. pylori infection and gout has not been explored previously. Our study aimed to investigate the association of gout and H. pylori infection in hyperuricemia population in China. PATIENTS AND METHODS: This cross-sectional study was performed among the subjects who underwent health checkup in our health promotion center from January 1, 2020 to December 31, 2021...
April 27, 2024: Gut Pathogens
#39
JOURNAL ARTICLE
Thi Mai Ngan Nguyen, Van Huy Tran, Thi Minh Thi Ha
Helicobacter pylori is the most common cause of gastroduodenal diseases. The concept that cagA-positive H. pylori is a risk factor for gastric cancer appears to be true only for H. pylori strains from Western countries. Other virulent genes may have a synergistic interaction with cagA during pathogenesis. This study aims to investigate H. pylori cagA, vacA, and iceA prevalence, genotypes, and their association to clinical outcomes in Vietnamese patients. The cagA status and vacA and iceA genotypes were determined using the PCR technique on DNA extracted from gastric biopsies of 141 patients with gastroduodenal diseases...
April 27, 2024: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
#40
COMPARATIVE STUDY
I L Naydenova, A B Danilov, A V Simonova, A A Pilipovich, E G Filatova
OBJECTIVE: To identify changes in the microbiome of saliva and to compare it with the microbiome of the oropharynx of patients with migraine. MATERIAL AND METHODS: Sixty patients with migraine (21-56 years old), were examined using a headache diary, MIDAS and VAS. A microbiological examination of saliva and smear from the mucosa of the posterior wall of the oropharynx with evaluation by the method of mass spectrometry of microbial markers (MSMM) with the determination of 57 microorganisms was performed...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
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