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Head and beck cancer

Benedicta E Beck-Broichsitter, Jörn Huck, Thomas Küchler, Daniela Hauke, Jürgen Hedderich, Jörg Wiltfang, Stephan T Becker
PURPOSE: The extent of functional impairment after ablative surgery in the orofacial region may be directly reflected in a reduction in Quality of Life. This study intended to compare the patients' perception with an objective functional evaluation of the orofacial system in order to bilaterally distinguish direct influence factors. METHODS: A total of 45 patients were included in this study and were asked to complete the European Organisation for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-30) and the Head and Neck 35 Module (H&N 35)...
October 18, 2016: Journal of Cancer Research and Clinical Oncology
Nosayaba Osazuwa-Peters, Eric Adjei Boakye, Betty Y Chen, Jennifer Clancy, Patrice L Vallot, Jonathan L Su, Geoffrey E Beck, Mark A Varvares
Importance: The incidence of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is increasing in the United States and may be underestimated among black individuals. Characterizing the current knowledge level among black individuals is critical to developing interventions to increase awareness. Objective: To describe the sociodemographic correlates of knowledge and risk perception of HPV and HPV-associated OPSCC among a predominantly black population...
October 6, 2016: JAMA Otolaryngology—Head & Neck Surgery
O M E E Mahmoud, R Beck, E Kalyoussef, S Baredes, R C Park, S Kim
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Kristen McCarter, Úrsula Martínez, Ben Britton, Amanda Baker, Billie Bonevski, Gregory Carter, Alison Beck, Chris Wratten, Ashleigh Guillaumier, Sean A Halpin, Luke Wolfenden
OBJECTIVE: To examine the effectiveness of smoking cessation interventions in improving cessation rates and smoking related behaviour in patients with head and neck cancer (HNC). DESIGN: A systematic review of randomised and non-randomised controlled trials. METHODS: We searched the following data sources: CENTRAL in the Cochrane Library, MEDLINE, EMBASE, PsycINFO and CINAHL up to February 2016. A search of reference lists of included studies and Google Scholar (first 200 citations published online between 2000 and February 2016) was also undertaken...
2016: BMJ Open
Tim N Beck, Rachel Georgopoulos, Elena I Shagisultanova, David Sarcu, Elizabeth A Handorf, Cara Dubyk, Miriam N Lango, John A Ridge, Igor Astsaturov, Ilya G Serebriiskii, Barbara A Burtness, Ranee Mehra, Erica A Golemis
Clinical decision making for human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is predominantly guided by disease stage and anatomic location, with few validated biomarkers. The epidermal growth factor receptor (EGFR) is an important therapeutic target, but its value in guiding therapeutic decision making remains ambiguous. We integrated analysis of clinically annotated tissue microarrays with analysis of data available through the TCGA, to investigate the idea that expression signatures involving EGFR, proteins regulating EGFR function, and core cell-cycle modulators might serve as prognostic or drug response-predictive biomarkers...
October 2016: Molecular Cancer Therapeutics
Rahul Yadav, Ravi Vattepu, Moriah R Beck
Actin cytoskeleton remodeling requires the coordinated action of a large number of actin binding proteins that reorganize the actin cytoskeleton by promoting polymerization, stabilizing filaments, causing branching, or crosslinking filaments. Palladin is a key cytoskeletal actin binding protein whose normal function is to enable cell motility during development of tissues and organs of the embryo and in wound healing, but palladin is also responsible for regulating the ability of cancer cells to become invasive and metastatic...
October 9, 2016: Journal of Molecular Biology
Ayşegül Batıoğlu-Karaaltın, Zerrin Binbay, Özgür Yiğit, Zehra Dönmez
OBJECTIVE: In this study patients who have undergone partial (PL) or total laryngectomy (TL) were evaluated for life quality, self-esteem and sexual dysfunctions. METHODS: 108 patients who received TL or PL without tracheostoma were included in this study. During patient interview, sociodemographical data form, European Organization for Research and Treatment of Cancer, Life Questionnaire Core 30 Items, Cancer and Head and Neck module-35 Items (EORTC QLQ-C30 and H&N35) were filled and patients were also asked to fill in Arizona Sexual Experiences Scale (ASEX), Beck's Depression Inventory (BDI), Beck's Anxiety Inventory (BAI) and Rosenberg Self-Esteem Scale (RSES) forms...
April 16, 2016: Auris, Nasus, Larynx
Jonathan Ma, Sadhika Malladi, Andrew H Beck
Though patient sex influences response to cancer treatments, little is known of the molecular causes, and cancer therapies are generally given irrespective of patient sex. We assessed transcriptomic differences in tumors from men and women spanning 17 cancer types, and we assessed differential expression between tumor and normal samples stratified by sex across 7 cancers. We used the LincsCloud platform to perform Connectivity Map analyses to link transcriptomic signatures identified in male and female tumors with chemical and genetic perturbagens, and we performed permutation testing to identify perturbagens that showed significantly differential connectivity with male and female tumors...
2016: Scientific Reports
Tilo Schlittenbauer, Martin Zeilinger, Emeka Nkenke, Sebastian Kreißel, Matthias C Wurm, Michael Lell, Torsten Kuwert, Michael Beck
Diagnostic imaging of head and neck cancer has made enormous progress during recent years. Next to morphological imaging modalities (computed tomography [CT] and magnetic resonance imaging [MRI]), there are also hybrid imaging systems that combine functional and morphological information (positron emission tomography [PET]/CT and PET/MRI). The aim of this study was to compare the diagnostic accuracy of PET/MRI in the diagnosis of head and neck cancer with other imaging modalities (MRI, CT, PET/CT). Ten patients (nine male and one female) with histologically proven oral squamous cell carcinoma participated in an 18 F-FDG-PET/CT scan and an additional 18 F-FDG PET/MRI scan prior to surgery...
December 2015: Journal of Cranio-maxillo-facial Surgery
Alison Kate Beck, Amanda Baker, Ben Britton, Chris Wratten, Judith Bauer, Luke Wolfenden, Gregory Carter
BACKGROUND: The confidence with which researchers can comment on intervention efficacy relies on evaluation and consideration of intervention fidelity. Accordingly, there have been calls to increase the transparency with which fidelity methodology is reported. Despite this, consideration and/or reporting of fidelity methods remains poor. We seek to address this gap by describing the methodology for promoting and facilitating the evaluation of intervention fidelity in The EAT (Eating As Treatment) project: a multi-site stepped wedge randomised controlled trial of a dietitian delivered behaviour change counselling intervention to improve nutrition (primary outcome) in head and neck cancer patients undergoing radiotherapy...
2015: Trials
Shin-Ae Kim, Jong-Lyel Roh, Sang-Ah Lee, Sang-Wook Lee, Sung-Bae Kim, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: The emotional status of cancer patients is associated with disease course and treatment outcomes. In this study, the authors evaluated associations between the presence of pretreatment depression and pretreatment quality of life (QOL), nutritional status, and survival outcomes in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: For this prospective study, 241 patients with previously untreated HNSCC who underwent curative treatments were enrolled...
January 1, 2016: Cancer
Tim N Beck, John Kaczmar, Elizabeth Handorf, Anna Nikonova, Cara Dubyk, Suraj Peri, Miriam Lango, John A Ridge, Ilya G Serebriiskii, Barbara Burtness, Erica A Golemis, Ranee Mehra
Locally advanced squamous cell carcinoma of the head and neck (SCCHN) that is not associated with human papillomavirus (HPV) has a poor prognosis in contrast to HPV-positive disease. To better understand the importance of RB1 activity in HPV-negative SCCHN, we investigated the prognostic value of inhibitory CDK4/6 phosphorylation of RB1 on threonine 356 (T356) in archival HPV-negative tumor specimens from patients who underwent surgical resection and adjuvant radiation. We benchmarked pT356RB1 to total RB1, Ki67, pT202/Y204ERK1/2, and TP53, as quantified by automatic quantitative analysis (AQUA), and correlated protein expression with tumor stage and grade...
August 7, 2015: Oncotarget
Ben Britton, Kristen McCarter, Amanda Baker, Luke Wolfenden, Chris Wratten, Judith Bauer, Alison Beck, Patrick McElduff, Sean Halpin, Gregory Carter
INTRODUCTION: Maintaining adequate nutrition for Head and Neck Cancer (HNC) patients is challenging due to both the malignancy and the rigours of radiation treatment. As yet, health behaviour interventions designed to maintain or improve nutrition in patients with HNC have not been evaluated. The proposed trial builds on promising pilot data, and evaluates the effectiveness of a dietitian-delivered health behaviour intervention to reduce malnutrition in patients with HNC undergoing radiotherapy: Eating As Treatment (EAT)...
2015: BMJ Open
M A de Cerqueira, W W Laranja, B C F Sanches, C R Monti, L O Reis
Focal cryoablation (FC), brachytherapy (B) and active surveillance (AS) were offered to patients diagnosed with very low-risk prostate cancer (VLRPC) in an equal access protocol. Comprehensive validated self-report questionnaires accessed patients' erectile (IIEF-5) and voiding (IPSS) functions, Beck scales measured anxiety (BAI), hopelessness (BHS) and depression (BDI), SF-36 reflected patients' quality of life added to the emotional thermometers including five visual analogue scales (distress, anxiety, depression, anger and need for help)...
November 2015: European Journal of Cancer Care
Audrey Cristina Bueno, Raquel Conceição Ferreira, Luis Otávio Miranda Cota, Guilherme Carvalho Silva, Cláudia Silami Magalhães, Allyson Nogueira Moreira
PURPOSE: Different periodontitis case definitions have been used in clinical research and epidemiology. The aim of this study was to determine more accurate criterion for the definition of mild and moderate periodontitis case to be applied to head and neck cancer individuals before radiotherapy. METHODS: The frequency of periodontitis in a sample of 84 individuals was determined according to different diagnostic criteria: (1) Lopez et al. (2002);(2) Hujoel et al...
September 2015: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Andrew Feber, Manit Arya, Patricia de Winter, Muhammad Saqib, Raj Nigam, Peter R Malone, Wei Shen Tan, Simon Rodney, Matthias Lechner, Alex Freeman, Charles Jameson, Asif Muneer, Stephan Beck, John D Kelly
PURPOSE: Penile cancer is a rare malignancy in the developed world with just more than 1,600 new cases diagnosed in the United States per year; however, the incidence is much higher in developing countries. Although HPV is known to contribute to tumorigenesis, little is known about the genetic or epigenetic alterations defining penile cancer. EXPERIMENTAL DESIGN: Using high-density genome-wide methylation arrays, we have identified epigenetic alterations associated with penile cancer...
March 1, 2015: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Christian Meerwein, Thomas F Pézier, Beatrice Beck-Schimmer, Stephan Schmid, Gerhard F Huber
QUESTIONS UNDER STUDY: The aim of this study was to evaluate two practices of airway management in patients undergoing head and neck cancer (HNC) resection and microvascular free tissue transfer (MFTT), and to assess the advantages and disadvantages of the two approaches. METHODS: Patients undergoing a delayed extubation approach (NO-TRACH group) and patients undergoing primary tracheotomy (PRIM-TRACH group) were retrospectively evaluated in terms of perioperative and postoperative outcome measures...
2014: Swiss Medical Weekly
Gareth A Wilson, Matthias Lechner, Anna Köferle, Helena Caren, Lee M Butcher, Andrew Feber, Tim Fenton, Amrita Jay, Chris Boshoff, Stephan Beck
One in six cancers worldwide is caused by infection and human papillomavirus (HPV) is one of the main culprits. To better understand the dynamics of HPV integration and its effect on both the viral and host methylomes, we conducted whole-genome DNA methylation analysis using MeDIP-seq of HPV+ and HPV- head and neck squamous cell carcinoma (HNSCC). We determined the viral subtype to be HPV-16 in all cases and show that HPV-16 integrates into the host genome at multiple random sites and that this process predominantly involves the transcriptional repressor gene (E2) in the viral genome...
September 2013: Epigenetics: Official Journal of the DNA Methylation Society
Benjamin K Poulose, Joan Kaiser, William C Beck, Pearlie Jackson, William H Nealon, Kenneth W Sharp, Michael D Holzman
BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) remains a mainstay of enteral access. Thirty-day mortality for PEG has ranged from 16 to 43 %. This study aims to discern patient groups that demonstrate limited survival after PEG placement. The Enterprise Data Warehouse (EDW) concept allows an efficient means of integrating administrative, clinical, and quality-of-life data. On the basis of this concept, we developed the Vanderbilt Procedural Outcomes Database (VPOD) and analyzed these data for evaluation of post-PEG mortality over time...
November 2013: Surgical Endoscopy
Matthias Lechner, Garrett M Frampton, Tim Fenton, Andrew Feber, Gary Palmer, Amrita Jay, Nischalan Pillay, Martin Forster, Maureen T Cronin, Doron Lipson, Vincent A Miller, Timothy A Brennan, Stephen Henderson, Francis Vaz, Paul O'Flynn, Nicholas Kalavrezos, Roman Yelensky, Stephan Beck, Philip J Stephens, Chris Boshoff
BACKGROUND: Human papillomavirus positive (HPV+) head and neck squamous cell carcinoma (HNSCC) is an emerging disease, representing a distinct clinical and epidemiological entity. Understanding the genetic basis of this specific subtype of cancer could allow therapeutic targeting of affected pathways for a stratified medicine approach. METHODS: Twenty HPV+ and 20 HPV- laser-capture microdissected oropharyngeal carcinomas were used for paired-end sequencing of hybrid-captured DNA, targeting 3,230 exons in 182 genes often mutated in cancer...
2013: Genome Medicine
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