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Adult functional constipation

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https://www.readbyqxmd.com/read/27895411/reoperation-in-an-adult-female-with-right-sided-hirschsprung-s-disease-complicated-by-refractory-hypertension-and-cough
#1
Zhi-Jian Wei, Lei Huang, A-Man Xu
Hirschsprung's disease (HD) is an intestinal malformation caused by the innate absence of ganglion cells in the neural plexus of the colorectal wall, and is most common in male infants. It is rare in adult, and is usually left-sided. Herein we reported based on the CARE guidelines a case of a 47-year-old adult female suffering from "right-sided" HD complicated by refractory hypertension and cough. The patient with a history of cesarean section and with digestive unfitness (abdominal pain, distention, and constipation) only since 20 years old had recurrence of HD after initial surgery due to the incomplete removal of the HD-affected bowel based on a diagnosis of "chronic ileus", leading to the relapse of the digestive symptoms and the emergence of some intractable circulatory and respiratory complications which could be hardly controlled by conservative treatment...
November 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27894765/outcome-in-adults-with-anorectal-malformations-in-relation-to-modern-classification-which-patients-do-we-need-to-follow-beyond-childhood
#2
Johan Danielson, Urban Karlbom, Wilhelm Graf, Tomas Wester
BACKGROUND/PURPOSE: Knowledge about the functional outcome in adults with anorectal malformations is essential to organize structured transition to adult care for this patient group. The aim of this study was to investigate the functional outcome and quality of life in adults with anorectal malformations characterized according to the Krickenbeck classification. METHODS: Of 256 patients diagnosed with anorectal malformations at our institution in 1961-1993, 203 patients could be traced and were invited to participate in the study...
November 15, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27891230/development-of-a-population-pharmacokinetic-model-of-prucalopride-in-children-with-functional-constipation
#3
Erno van Schaick, Marc A Benninga, Amy Levine, Mats Magnusson, Steven Troy
A recent phase 3 trial of prucalopride in children with functional constipation (SPD555-303 ClinicalTrials.gov Identifier: NCT01330381) reported negative efficacy results. Here, we developed a population pharmacokinetic (PK) model of prucalopride in children to assess prucalopride exposure in SPD555-303. An initial population PK model in children was developed based on sampled single-dose data from a phase 1 study (PRU-USA-12). This model was subsequently updated with sampled data from SPD555-303 and used to simulate plasma concentration-time profiles for children aged 6 months to 18 years who were treated once daily with prucalopride 0...
August 2016: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/27871178/use-of-polyethylene-glycol-in-functional-constipation-and-fecal-impaction
#4
Miguel Mínguez, Antonio López Higueras, Javier Júdez
OBJECTIVE: The objective of this study was to evaluate in an analytical and descriptive manner the evidence published so far on the use of polyethylene glycol (PEG), with or without electrolytes, in the management of functional constipation and the treatment of fecal impaction. METHODOLOGY: Search on MEDLINE, EMBASE and Cochrane databases until May 2016 of all publications adjusted to the following terms: constipation AND/OR fecal impaction AND (PEG OR polyethylene glycol OR macrogol OR movicol OR idralax OR miralax OR transipeg OR forlax OR golytely OR isocolan OR mulytely) NOT colonoscopy...
November 22, 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27810257/-clinical-practice-guidelines-irritable-bowel-syndrome-with-constipation-and-functional-constipation-in-adults-concept-diagnosis-and-healthcare-continuity-part-1-of-2
#5
F Mearin, C Ciriza, M Mínguez, E Rey, J J Mascort, E Peña, P Cañones, J Júdez
In this Clinical practice guide, an analysis is made of the diagnosis and treatment of adult patients with constipation and abdominal discomfort, under the spectrum of irritable bowel syndrome and functional constipation. These have an important personal, health and social impact, affecting the quality of life of these patients. In irritable bowel syndrome with a predominance of constipation, this is the predominant change in bowel movements, with recurrent abdominal pain, bloating and frequent abdominal distension...
October 31, 2016: Semergen
https://www.readbyqxmd.com/read/27776217/a-randomised-double-blind-placebo-controlled-clinical-study-the-effects-of-a-synbiotic-lepicol-in-adults-with-chronic-functional-constipation
#6
Sally Cudmore, Andrea Doolan, Seán Lacey, Fergus Shanahan
The study objective was to evaluate the safety and effects of Lepicol® (pysllium fibre, inulin and 5 probiotic strains) in adults with chronic, functional constipation during a 4 week intervention. 69 subjects with functional constipation according to Rome III criteria were randomised to receive Lepicol (n = 35) or placebo (n = 34) daily. Both groups had improved frequency of bowel movements, with an increase of 1.082 bowel movements in the Lepicol group over placebo after one week, and 1.079 more than placebo after week 2, but with no significant difference at week 4...
October 24, 2016: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/27736891/gastrointestinal-dysfunction-in-patients-with-duchenne-muscular-dystrophy
#7
Christian M Lo Cascio, Oliver Goetze, Tsogyal D Latshang, Sena Bluemel, Thomas Frauenfelder, Konrad E Bloch
BACKGROUND: In adult patients with Duchenne muscular dystrophy (DMD) life-threatening constipation has been reported. Since gastrointestinal function in DMD has not been rigorously studied we investigated objective and subjective manifestations of gastrointestinal disturbances in DMD patients. METHODS: In 33 patients with DMD, age 12-41 years, eating behavior and gastrointestinal symptoms were evaluated by questionnaires. Gastric emptying half time (T1/2) and oro-cecal transit time (OCTT) were evaluated by analyzing 13CO2 exhalation curves after ingestion of 13C labeled test meals...
2016: PloS One
https://www.readbyqxmd.com/read/27680077/-preliminary-exploration-on-accurately-preoperative-evaluation-of-colonic-lesions-in-slow-transit-constipation-complicated-with-adult-megacolon
#8
Zhenhua Yu, Qi Liu, Zhigang Xiao, Dan Li, Xing Huang, Zhongcheng Huang
OBJECTIVE: To investigate the application value of colonic transit test (CTT) combined with anorectal manometry (ARM), barium enema (BE) and defecography (DFG) in accurately evaluating colonic lesions of slow transit constipation complicated with adult megacolon. METHODS: Clinical data of 47 above patients admitted between October 2007 and February 2015 in the People's Hospital of Hunan Province were analyzed retrospectively. All the patients were examined with≥2 times of CTT combined with ARM and BE, and 42 cases received additional DFG at the same time, to evaluate colonic lesions before operation...
September 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27679978/functional-gastrointestinal-disorders-in-greek-children-based-on-rome-iii-criteria-identifying-the-child-at-risk
#9
I Bouzios, G Chouliaras, G P Chrousos, E Roma, V Gemou-Engesaeth
BACKGROUND: Functional gastrointestinal disorders (FGIDs) are a common, diverse group of disorders of unknown etiology, resulting in significant socieconomic burden. In this study, we aimed to assess the prevalence of FGIDs in children aged 6-18 years and examine their association with various demographic and socioeconomic parameters. METHODS: This was a school-based, cross-sectional study approved by the relevant government authorities. Informed consent was obtained by the legal representatives of all children who participated...
September 28, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27570423/childhood-constipation-as-an-emerging-public-health-problem
#10
REVIEW
Shaman Rajindrajith, Niranga Manjuri Devanarayana, Bonaventure Jayasiri Crispus Perera, Marc Alexander Benninga
Functional constipation (FC) is a significant health problem in children and contrary to common belief, has serious ramifications on the lives of children and their families. It is defined by the Rome criteria which encourage the use of multiple clinical features for diagnosis. FC in children has a high prevalence (0.7%-29%) worldwide, both in developed and developing countries. Biopsychosocial risk factors such as psychological stress, poor dietary habits, obesity and child maltreatment are commonly identified predisposing factors for FC...
August 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27528801/patient-considerations-in-the-management-of-chronic-constipation-focus-on-prucalopride
#11
REVIEW
Andrea Shin
Chronic constipation is a common condition that significantly impacts health care utilization, productivity, and quality of life. Laxatives are commonly used, although often insufficient in restoring normal bowel function or providing adequate relief. There remains a significant need for the development of novel agents to optimize treatment of this condition. This review provides an overview of the preclinical and clinical trial data, supporting the efficacy and safety of prucalopride, a highly selective 5-HT4 receptor agonist that has been approved by the European Medicine Agency for the treatment of chronic constipation in adults who have failed standard laxative therapy...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27514083/-subtotal-colectomy-with-mesorectumectomy-in-surgical-treatment-of-a-hirschsprung-s-disease-in-adults
#12
A V Vorobey, A M Makhmudov, V K Tikhon, F M Vysotskiy, O I Senkevich, S A Novakovskaya
Hirschsprung's disease (HD) in adults constitutes a rare cause of chronic constipation. Surgical intervention constitutes the only one radical method of treatment of HD. The investigation objective was to improve the functional results of treatment of HD in adults, using a new surgical approach elaboration. The method of surgical treatment of a HD in adults was proposed, which envisages a conduction of distal subtotal colecto- my and total mesorectumectomy with formation of a coecoreservoiroanal anastomosis...
March 2016: Klinichna Khirurhiia
https://www.readbyqxmd.com/read/27489708/duodenal-neuroendocrine-tumor-and-the-onset-of-severe-diabetes-mellitus-in-a-us-veteran
#13
Lauren Murray, Chelsey Haley, Cristóbal S Berry-Cabán, Almond Toledo
OBJECTIVE: Neuroendocrine tumors are neoplasms derived from endocrine cells, most commonly occurring in the gastrointestinal tract. Duodenal neuroendocrine tumors are rare tumors averaging 1.2-1.5 cm, and most are asymptomatic. Common presentation is abdominal pain, upper gastrointestinal bleed, constipation, anemia, and jaundice. METHODS: An adult, Black, male patient with newly diagnosed diabetes mellitus presented to the emergency department with elevated liver function test and fatigue...
2016: SAGE open medical case reports
https://www.readbyqxmd.com/read/27412159/health-survey-of-adults-with-hereditary-spastic-paraparesis-compared-to-population-study-controls
#14
Krister W Fjermestad, Øivind J Kanavin, Eva E Næss, Lise B Hoxmark, Grete Hummelvoll
BACKGROUND: Hereditary spastic paraparesis (HSP) is a rare neurodegenerative condition characterized by slowly progressive spastic weakness of the lower limbs and urinary sphincter dysfunction. Complex HSP involves additional neurologic symptoms and signs like ataxia, extra pyramidal signs, polyneuropathy, and cognitive decline. Little is known about the disease burden for adults with HSP beyond the described core symptoms. METHODS: A cross-sectional survey of 108 adults aged 30 years and older (Mage = 57...
2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27258460/constipation-prevalence-and-associated-factors-in-adults-living-in-londrina-southern-brazil
#15
Fernanda Mateus Queiroz Schmidt, Vera Lúcia Conceição de Gouveia Santos, Rita de Cássia Domansky, José Marcio Jorge Neves
The aims of this study were to estimate the prevalence of constipation and identify associated factors among adults living in an urban area in Londrina, Brazil. This was a secondary analysis of an epidemiological, population-based study on bowel habit performed in 2008 with 2,162 individuals selected through cluster sampling. Interviews were administered using a sociodemographic questionnaire and the adapted and validated Brazilian version of the "Bowel Function in the Community" tool. Variables from the original database were used to determine the prevalence of constipation (according to the Rome Criteria III) and associated factors...
May 2016: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
https://www.readbyqxmd.com/read/27236579/sacral-nerve-stimulation-in-the-treatment-of-bowel-dysfunction-from-imperforate-anus-a-case-report
#16
Saleh M Eftaiha, George Melich, Ajit Pai, Slawomir J Marecik, Leela M Prasad, John J Park
INTRODUCTION: Bowel dysfunction (fecal incontinence and constipation) presents in over 50% of patients after treatment of congenital anal malformations. Sacral nerve stimulation (SNS) for the treatment of fecal incontinence improves function in the majority of patients. We present a case report of the treatment of bowel dysfunction with sacral nerve stimulation in a patient with a history of an imperforate anus. PRESENTATION OF CASE: A twenty year-old female with a history of imperforate anus at birth, repaired during infancy with anorectoplasty, presented with fecal incontinence and constipation...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27230827/clinical-practice-guideline-irritable-bowel-syndrome-with-constipation-and-functional-constipation-in-the-adult
#17
Fermín Mearin, Constanza Ciriza, Miguel Mínguez, Enrique Rey, Juan José Mascort, Enrique Peña, Pedro Cañones, Javier Júdez
In this Clinical Practice Guideline we discuss the diagnostic and therapeutic approach of adult patients with constipation and abdominal complaints at the confluence of the irritable bowel syndrome spectrum and functional constipation. Both conditions are included among the functional bowel disorders, and have a significant personal, healthcare, and social impact, affecting the quality of life of the patients who suffer from them. The first one is the irritable bowel syndrome subtype, where constipation represents the predominant complaint, in association with recurrent abdominal pain, bloating, and abdominal distension...
June 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27225443/nation-wide-epidemiological-study-of-japanese-patients-with-rare-viral-myelopathy-using-novel-registration-system-ham-net
#18
Ariella L G Coler-Reilly, Naoko Yagishita, Hiroko Suzuki, Tomoo Sato, Natsumi Araya, Eisuke Inoue, Ayako Takata, Yoshihisa Yamano
BACKGROUND: At least one million people are infected with human T-lymphotropic virus type 1 (HTLV-1) in Japan, a small percentage of whom develop HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) or adult T-cell leukemia/lymphoma (ATLL). Patients with HAM/TSP suffer from progressively worsening myelopathic symptoms, such as motor disability and bladder dysfunction, and may become wheelchair-bound or even bedridden. METHODS: To learn more about this rare, debilitating disease, we established the national registration system "HAM-net" in March 2012...
2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27190892/an-unusual-lesser-sac-collection-causing-gastric-outlet-obstruction-with-coincidental-occurrence-of-leriche-s-syndrome-a-case-report
#19
Anand Singla, Darshanjeet Singh Walia, Rishabhpreet Kaur
Gastric outlet obstruction in adults is usually caused by pyloric stenosis secondary to peptic ulcer disease or malignancy. However, there are few other causes such as a foreign body and external compression due to pseudocyst pancreas. We present a rare aetiology of a large collection of pus in the lesser sac in our patient causing gastric outlet obstruction. A perforated peptic ulcer was suspected in our patient who had symptoms of sudden onset pain in epigastric region which was referred to back. This was followed by pain in upper abdomen, vomiting, constipation and fever for which patient was being managed conservatively before being referred to us...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27184278/risk-factors-for-malnutrition-in-older-adults-a-systematic-review-of-the-literature-based-on-longitudinal-data
#20
REVIEW
Nádia Cristina Fávaro Moreira, Stefanie Krausch-Hofmann, Christophe Matthys, Carine Vereecken, Erika Vanhauwaert, Anja Declercq, Geertruida Elsiena Bekkering, Joke Duyck
The present systematic review critically examines the available scientific literature on risk factors for malnutrition in the older population (aged ≥65 y). A systematic search was conducted in MEDLINE, reviewing reference lists from 2000 until March 2015. The 2499 papers identified were subjected to inclusion criteria that evaluated the study quality according to items from validated guidelines. Only papers that provided information on a variable's effect on the development of malnutrition, which requires longitudinal data, were included...
May 2016: Advances in Nutrition
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