keyword
https://read.qxmd.com/read/38436908/impact-of-process-interference-on-memory-encoding-and-retrieval-processes-in-dual-task-situations
#21
JOURNAL ARTICLE
Sandra Hensen, Iring Koch, Patricia Hirsch
Dual-tasks at the memory encoding stage have been shown to decrease recall performance and impair concurrent task performance. In contrast, studies on the effect of dual-tasks at the memory retrieval stage observed mixed results. Which cognitive mechanisms are underlying this dual-task interference is still an unresolved question. In the present study, we investigated the influence of a concurrent reaction-time task on the performance in a long-term memory task in two experiments. In Experiment 1, participants performed an auditory-verbal free recall memory task and a visual-manual spatial Stroop task in a single or dual-task condition, either at the encoding or retrieval stage of the memory task...
March 4, 2024: Memory & Cognition
https://read.qxmd.com/read/38432446/csf1r-inhibition-reprograms-tumor-associated-macrophages-to-potentiate-anti-pd-1-therapy-efficacy-against-colorectal-cancer
#22
JOURNAL ARTICLE
Qi Lv, Yishu Zhang, Wen Gao, Juan Wang, Yaowen Hu, Hongqiong Yang, Ying Xie, Yingshan Lv, Heyuan Zhang, Dapeng Wu, Lihong Hu, Junwei Wang
PD-1 blockade therapy has made great breakthroughs in treatment of multiple solid tumors. However, patients with microsatellite-stable (MSS) colorectal cancer (CRC) respond poorly to anti-PD-1 immunotherapy. Although CRC patients with microstatellite instability (MSI) or microsatellite instability-high (MSI-H) can benefit from PD-1 blockade therapy, there are still some problems such as tumor recurrence. Tumor-associated macrophages (TAMs), most abundant immune components in tumor microenvironment (TME), largely limit the therapeutic efficacy of anti-PD-1 against CRC...
March 1, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38428174/long-term-memory-consolidation-of-new-words-in-children-with-self-limited-epilepsy-with-centro-temporal-spikes
#23
JOURNAL ARTICLE
C Mayor, C Moser, C Korff
Accelerated long-term forgetting has been studied and demonstrated in adults with epilepsy. In contrast, the question of long-term consolidation (delays > 1 day) in children with epilepsy shows conflicting results. However, childhood is a period of life in which the encoding and long-term storage of new words is essential for the development of knowledge and learning. The aim of this study was therefore to investigate long-term memory consolidation skills in children with self-limited epilepsy with centro-temporal spikes (SeLECTS), using a paradigm exploring new words encoding skills and their long-term consolidation over one-week delay...
February 29, 2024: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/38422863/the-effects-of-diazepam-on-fear-extinction-in-nulliparous-and-primiparous-female-rats
#24
JOURNAL ARTICLE
Jodie E Pestana, Tasfia Kabir, Bronwyn M Graham
Benzodiazepines undermine the success of exposure therapy in humans with anxiety disorders, and impair the long-term memory of fear extinction (the laboratory basis of exposure therapy) in rodents. However, most rodent studies on fear extinction and benzodiazepines have been conducted in male rodents. In female rodents, the estrous cycle influences the consolidation of fear extinction memories and sensitivity to benzodiazepines. In addition, pregnancy leads to long-term changes in the neurobiological, hormonal, and behavioural features of fear extinction, as well as the responsivity to benzodiazepines...
February 28, 2024: Hormones and Behavior
https://read.qxmd.com/read/38421713/nkt-licensed-in-vivo-dendritic-cell-based-immunotherapy-as-cellular-immunodrugs-for-cancer-treatment
#25
JOURNAL ARTICLE
Shin-Ichiro Fujii, Kanako Shimizu
With the advent of new therapies, immunotherapy has gained attention as a critical modality. After the discovery of the natural killer T (NKT) cells ligand, ex vivo cultured dendritic cells (DCs) loaded with NKT ligand (especially α-galactosylceramide (α-GalCer) (DC/Gal) or ex vivo expanded NKT transfer studies were clinically examined in several institutes. To prevent tumoral immune escape, the link between innate and adaptive immunity, in situ selective targeting of DCs has been attempted; however, protocol optimization was required...
2024: Critical Reviews in Oncogenesis
https://read.qxmd.com/read/38420860/-i-couldn-t-connect-the-wires-in-my-brain-young-adult-cancer-survivors-experience-with-cognitive-functioning
#26
JOURNAL ARTICLE
Danielle B Tometich, Taylor Welniak, Lisa Gudenkauf, Melinda L Maconi, Hayden J Fulton, Dinorah Martinez Tyson, Kellie Zambrano, Syed Hasan, Yvelise Rodriguez, Crystal Bryant, Xiaoyin Li, Damon R Reed, Laura B Oswald, Andrew Galligan, Brent J Small, Heather S L Jim
OBJECTIVE: There is a dearth of literature describing young adult (YA) cancer survivors' experiences with cancer-related cognitive impairment (CRCI). We aimed to elucidate CRCI among YA cancer survivors and identify potentially modifiable risk factors. METHODS: We conducted individual qualitative interviews with YA cancer survivors aged 18-30 years at study enrollment and used applied thematic analysis to identify themes across three topics (i.e., affected cognitive abilities, risk and protective factors influencing the impact of CRCI, and strategies for coping with CRCI)...
March 2024: Psycho-oncology
https://read.qxmd.com/read/38415278/a-classification-based-generative-approach-to-selective-targeting-of-global-slow-oscillations-during-sleep
#27
JOURNAL ARTICLE
Mahmoud Alipour, SangCheol Seok, Sara C Mednick, Paola Malerba
BACKGROUND: Given sleep's crucial role in health and cognition, numerous sleep-based brain interventions are being developed, aiming to enhance cognitive function, particularly memory consolidation, by improving sleep. Research has shown that Transcranial Alternating Current Stimulation (tACS) during sleep can enhance memory performance, especially when used in a closed-loop (cl-tACS) mode that coordinates with sleep slow oscillations (SOs, 0.5-1.5Hz). However, sleep tACS research is characterized by mixed results across individuals, which are often attributed to individual variability...
2024: Frontiers in Human Neuroscience
https://read.qxmd.com/read/38411094/radiation-activated-resiquimod-prodrug-nanomaterials-for-enhancing-immune-checkpoint-inhibitor-therapy
#28
JOURNAL ARTICLE
Jiali Sun, Haochen Yao, Xitong Ren, Linjie Cui, Linlin Liu, Guoqing Wang, Zhaohui Tang
Immune checkpoint inhibitor (ICI) therapy is effectively employed in treating various malignancies. However, the response rate is constrained to 5-30%, which is attributed to differences in immune responses across different tumors. Overcoming all obstacles of multistep immune activation with monotherapy is difficult. Here, maleimide-modified resiquimod (R848) prodrug nanoparticles (MAL-NPs) are reported and combined with radiotherapy (RT) and anti-PD1 to enhance ICI therapy. MAL-NPs can promote antigen endocytosis by dendritic cells and are radio-reduced to produce R848...
February 27, 2024: Nano Letters
https://read.qxmd.com/read/38405990/closed-loop-electrical-stimulation-to-prevent-focal-epilepsy-progression-and-long-term-memory-impairment
#29
Jose J Ferrero, Ahnaf R Hassan, Zelin Yu, Zifang Zhao, Liang Ma, Cynthia Wu, Shan Shao, Takeshi Kawano, Judah Engel, Werner Doyle, Orrin Devinsky, Dion Khodagholy, Jennifer N Gelinas
UNLABELLED: Interictal epileptiform discharges (IEDs) are ubiquitously expressed in epileptic networks and disrupt cognitive functions. It is unclear whether addressing IED-induced dysfunction could improve epilepsy outcomes as most therapeutics target seizures. We show in a model of progressive hippocampal epilepsy that IEDs produce pathological oscillatory coupling which is associated with prolonged, hypersynchronous neural spiking in synaptically connected cortex and expands the brain territory capable of generating IEDs...
February 12, 2024: bioRxiv
https://read.qxmd.com/read/38405118/critical-roles-of-nicotinic-acetylcholine-receptors-in-olfactory-memory-formation-and-retrieval-in-crickets
#30
JOURNAL ARTICLE
Yukihisa Matsumoto, Chihiro Sato Matsumoto, Makoto Mizunami
Acetylcholine (ACh) is a major excitatory neurotransmitter in the insect central nervous system, and insect neurons express several types of ACh receptors (AChRs). AChRs are classified into two subgroups, muscarinic AChRs and nicotinic AChRs (nAChRs). nAChRs are also divided into two subgroups by sensitivity to α-bungarotoxin (α-BGT). The cricket Gryllus bimaculatus is one of the useful insects for studying the molecular mechanisms in olfactory learning and memory. However, the roles of nAChRs in olfactory learning and memory of the cricket are still unknown...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38403607/-spatial-navigation-method-based-on-the-entorhinal-hippocampal-prefrontal-information-transmission-circuit-of-rat-s-brain
#31
JOURNAL ARTICLE
Yishen Liao, Naigong Yu
Physiological studies have revealed that rats perform spatial localization relying on grid cells and place cells in the entorhinal-hippocampal CA3 structure. The dynamic connection between the entorhinal-hippocampal structure and the prefrontal cortex is crucial for navigation. Based on these findings, this paper proposes a spatial navigation method based on the entorhinal-hippocampal-prefrontal information transmission circuit of the rat's brain, with the aim of endowing the mobile robot with strong spatial navigation capability...
February 25, 2024: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://read.qxmd.com/read/38403011/the-role-of-the-m6a-m-demethylase-fto-in-memory-is-both-task-and-sex-dependent-in-mice
#32
JOURNAL ARTICLE
A M Leonetti, I R Galluzzo, T McLean, G Stefanelli, F Ramnaraign, S Holm, S M Winston, I L Reeves, M A Brimble, B J Walters
Formation of long-term memories requires learning-induced changes in both transcription and translation. Epitranscriptomic modifications of RNA recently emerged as critical regulators of RNA dynamics, whereby adenosine methylation (m6A) regulates translation, mRNA stability, mRNA localization, and memory formation. Prior work demonstrated a pro-memory phenotype of m6A, as loss of m6A impairs and loss of the m6A/m demethylase FTO improves memory formation. Critically, these experiments focused exclusively on aversive memory tasks and were only performed in male mice...
February 23, 2024: Neurobiology of Learning and Memory
https://read.qxmd.com/read/38388708/insights-into-attention-and-memory-difficulties-in-post-covid-syndrome-using-standardized-neuropsychological-tests-and-experimental-cognitive-tasks
#33
JOURNAL ARTICLE
Sandra Arbula, Elisabetta Pisanu, Giulia Bellavita, Alina Menichelli, Alberta Lunardelli, Giovanni Furlanis, Paolo Manganotti, Stefano Cappa, Raffaella Rumiati
The COVID-19 pandemic has given rise to post-acute cognitive symptoms, often described as 'brain fog'. To comprehensively grasp the extent of these issues, we conducted a study integrating traditional neuropsychological assessments with experimental cognitive tasks targeting attention control, working memory, and long-term memory, three cognitive domains most commonly associated with 'brain fog'. We enrolled 33 post-COVID patients, all self-reporting cognitive difficulties, and a matched control group (N = 27) for cognitive and psychological assessments...
February 22, 2024: Scientific Reports
https://read.qxmd.com/read/38383840/the-role-of-word-form-in-gender-processing-during-lexical-access-a-theoretical-review-and-novel-proposal-in-language-comprehension
#34
REVIEW
A R Sá-Leite, S Lago
In contrast to language production, there are few comprehension models of the representation and use of grammatical gender in long-term memory. To bridge this gap, we conducted a systematic review of empirical studies on the role of gender-form regularities in the recognition of nouns in isolation and within sentences. The results of a final sample of 40 studies suggest that there are two routes for the retrieval of gender during real-time comprehension: a form-based route and a lexical-based route. Our review indicates that the use of these routes depends on the degree of gender transparency of the language and the degree of overtness of the experimental paradigm...
February 21, 2024: Psychonomic Bulletin & Review
https://read.qxmd.com/read/38383579/directed-functional-connectivity-of-the-default-mode-network-of-young-and-older-healthy-subjects
#35
JOURNAL ARTICLE
Gadi Goelman, Rotem Dan, Ondrej Bezdicek, Robert Jech, Dana Ekstein
Alterations in the default mode network (DMN) are associated with aging. We assessed age-dependent changes of DMN interactions and correlations with a battery of neuropsychological tests, to understand the differences of DMN directed connectivity between young and older subjects. Using a novel multivariate analysis method on resting-state functional MRI data from fifty young and thirty-one healthy older subjects, we calculated intra- and inter-DMN 4-nodes directed pathways. For the old subject group, we calculated the partial correlations of inter-DMN pathways with: psychomotor speed and working memory, executive function, language, long-term memory and visuospatial function...
February 21, 2024: Scientific Reports
https://read.qxmd.com/read/38380798/the-interaction-of-linguistic-and-visual-cues-for-the-processing-of-case-in-russian-by-russian-german-bilinguals-an-eye-tracking-study
#36
JOURNAL ARTICLE
Serge Minor, Natalia Mitrofanova, Marit Westergaard
Modulation of visual attention in the Visual World Paradigm relies on parallel processing of linguistic and visual information. Previous studies have argued that the human linguistic capacity includes an aspect of anticipation of upcoming material. Such anticipation can be triggered by both lexical and grammatical/morphosyntactic cues. In this study, we investigated the relationship between comprehension and prediction by testing how subtle changes in visual representations can affect the processing of grammatical case cues in Russian by Russian-German bilingual children (n = 49, age 8-13)...
February 21, 2024: Topics in Cognitive Science
https://read.qxmd.com/read/38378883/does-value-based-prioritization-at-working-memory-enhance-long-term-memory
#37
JOURNAL ARTICLE
A L Atkinson, A H Waterman, R J Allen
Research has demonstrated that individuals can direct their attention to valuable information in both working memory and long-term memory tasks with observable effects on performance. However, it is currently unclear whether prioritising an item for a working memory task automatically translates into a boost at long-term memory. This was examined in two experiments using relatively short (250 ms per item; Experiment 1) and longer (500 ms per item; Experiment 2) encoding times. Participants first completed a visual working memory task, in which they were presented with series of photographs of everyday objects...
February 20, 2024: Memory & Cognition
https://read.qxmd.com/read/38368598/is-implicit-memory-associated-with-the-hippocampus
#38
JOURNAL ARTICLE
Ashley C Steinkrauss, Scott D Slotnick
According to the traditional memory-systems view, the hippocampus is critical during explicit (conscious) long-term memory, whereas other brain regions support implicit (nonconscious) memory. In the last two decades, some fMRI studies have reported hippocampal activity during implicit memory tasks. The aim of the present discussion paper was to identify whether any implicit memory fMRI studies have provided convincing evidence that the hippocampus is associated with nonconscious processes without being confounded by conscious processes...
February 18, 2024: Cognitive Neuroscience
https://read.qxmd.com/read/38361018/recognition-memory-decisions-made-with-short-and-long-term-retrieval
#39
JOURNAL ARTICLE
Shuchun Lea Lai, Rui Cao, Richard M Shiffrin
In the present research, we produce a coherent account of the storage and retrieval processes in short- and long-term event memory, and long-term knowledge, that produce response accuracy and response time in a wide variety of conditions in our studies of recognition memory. Two to nine pictures are studied sequentially followed by a target or foil test picture in four conditions used in Nosofsky et al. Journal of Experimental Psychology: Learning, Memory, and Cognition, 47, 316-342, (2021) and in our new paradigm: VM: target and foil responses to a given stimulus change from trial to trial; CM: the responses do not change from trial to trial; AN: every trial uses new stimuli; MIXED: combinations of VM, CN, and AN occur on each trial...
February 9, 2024: Memory & Cognition
https://read.qxmd.com/read/38360145/maternal-aerobic-exercise-decreases-the-effects-of-a-perinatal-western-diet-on-the-short-and-long-term-memory-of-cd1-mouse-progeny
#40
JOURNAL ARTICLE
Minerva Ortiz-Valladares, Ricardo Pedraza-Medina, Salma Rosales-Herrera, Jorge Guzmán-Muñiz
Maternal nutrition and physical activity during pregnancy and lactation can modify offspring development. Here, we investigated the effects of maternal aerobic exercise (AE) and Western diet (WD) on brain development, cognitive flexibility, and memory of progenies. Sixteen adult female mice were assigned to AE or sedentary groups (SED) and fed a balanced diet (BD) or WD. Offspring were categorized into four groups: WD+AE, WD+SED, BD+AE, and BD+SED. The AE group showed enhanced spontaneous alternation in the T-maze test, suggesting an improvement in working memory and tasks related to cognitive flexibility...
February 13, 2024: Neuroscience Letters
keyword
keyword
100362
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.