Luis Daniel Hernandez Torres, Flavia Rezende, Eva Peschke, Olga Will, Jan-Bernd Hövener, Frauke Spiecker, Ümit Özorhan, Josephine Lampe, Ines Stölting, Zouhair Aherrahrou, Carsten Künne, Kristina Kusche-Vihrog, Urte Matschl, Susanne Hille, Ralf P Brandes, Markus Schwaninger, Oliver J Müller, Walter Raasch
INTRODUCTION: The development of cognitive dysfunction is not necessarily associated with diet-induced obesity. We hypothesized that cognitive dysfunction might require additional vascular damage, for example, in atherosclerotic mice. METHODS: We induced atherosclerosis in male C57BL/6N mice by injecting AAV-PCSK9DY (2x1011 VG) and feeding them a cholesterol-rich Western diet. After 3 months, mice were examined for cognition using Barnes maze procedure and for cerebral blood flow...
2024: Frontiers in Endocrinology