keyword
https://read.qxmd.com/read/38485841/trkb-bdnf-signalling-and-arc-arg3-1-immediate-early-genes-in-the-anterior-cingulate-cortex-and-hippocampus-insights-into-novel-memory-milestones-through-behavioural-tagging
#1
JOURNAL ARTICLE
Mehar Naseem, Hiba Khan, Suhel Parvez
In recent years, there has been a surge in interest in investigating the mechanisms underlying memory consolidation. However, our understanding of the behavioural tagging (BT) model and its establishment in diverse brain regions remains limited. This study elucidates the contributions of the anterior cingulate cortex (ACC) and hippocampus in the formation of long-term memory (LTM) employing behaviour tagging as a model for studying the underlying mechanism of LTM formation in rats. Existing knowledge highlights a protein synthesis-dependent phase as imperative for LTM...
March 15, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38485526/express-age-related-contextual-cueing-features-are-more-evident-in-reaction-variability-than-in-reaction-time
#2
JOURNAL ARTICLE
Yipeng Yao, Rong Luo, Chengyu Fan, Yeke Qian, Xuelian Zang
Visual-spatial contextual cueing learning underpins the daily lives of older adults, enabling them to navigate their surroundings, perform daily activities, and maintain cognitive function. While the contextual cueing effect has received increasing attention from researchers, the relationship between this cognitive ability and healthy aging remains controversial. To investigate whether visual-spatial contextual cueing learning declines with age, we examined the contextual learning patterns of older (60-71 years old) and younger adults (18-26 years old) using a contextual-guided visual search paradigm and response variability measurements...
March 14, 2024: Quarterly Journal of Experimental Psychology: QJEP
https://read.qxmd.com/read/38470923/the-effects-of-mnemonic-variability-and-spacing-on-memory-over-multiple-timescales
#3
JOURNAL ARTICLE
Emily T Cowan, Yiwen Zhang, Benjamin M Rottman, Vishnu P Murty
The memory benefit that arises from distributing learning over time rather than in consecutive sessions is one of the most robust effects in cognitive psychology. While prior work has mainly focused on repeated exposures to the same information, in the real world, mnemonic content is dynamic, with some pieces of information staying stable while others vary. Thus, open questions remain about the efficacy of the spacing effect in the face of variability in the mnemonic content. Here, in two experiments, we investigated the contributions of mnemonic variability and the timescale of spacing intervals, ranging from seconds to days, to long-term memory...
March 19, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38470918/collective-neural-network-behavior-in-a-dynamically-driven-disordered-system-of-superconducting-loops
#4
JOURNAL ARTICLE
Uday S Goteti, Shane A Cybart, Robert C Dynes
Collective properties of complex systems composed of many interacting components such as neurons in our brain can be modeled by artificial networks based on disordered systems. We show that a disordered neural network of superconducting loops with Josephson junctions can exhibit computational properties like categorization and associative memory in the time evolution of its state in response to information from external excitations. Superconducting loops can trap multiples of fluxons in many discrete memory configurations defined by the local free energy minima in the configuration space of all possible states...
March 19, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38469142/incidence-of-microvascular-dysfunction-is-increased-in-hyperlipidemic-mice-reducing-cerebral-blood-flow-and-impairing-remote-memory
#5
JOURNAL ARTICLE
Luis Daniel Hernandez Torres, Flavia Rezende, Eva Peschke, Olga Will, Jan-Bernd Hövener, Frauke Spiecker, Ümit Özorhan, Josephine Lampe, Ines Stölting, Zouhair Aherrahrou, Carsten Künne, Kristina Kusche-Vihrog, Urte Matschl, Susanne Hille, Ralf P Brandes, Markus Schwaninger, Oliver J Müller, Walter Raasch
INTRODUCTION: The development of cognitive dysfunction is not necessarily associated with diet-induced obesity. We hypothesized that cognitive dysfunction might require additional vascular damage, for example, in atherosclerotic mice. METHODS: We induced atherosclerosis in male C57BL/6N mice by injecting AAV-PCSK9DY (2x1011 VG) and feeding them a cholesterol-rich Western diet. After 3 months, mice were examined for cognition using Barnes maze procedure and for cerebral blood flow...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38468589/genetic-and-epigenetic-dysregulation-of-innate-immune-mechanisms-in-autoinflammatory-diseases
#6
REVIEW
Laura M Merlo Pich, Athanasios Ziogas, Mihai G Netea
Dysregulation and hyperactivation of innate immune responses can lead to the onset of systemic autoinflammatory diseases. Monogenic autoinflammatory diseases are caused by inborn genetic errors and based on molecular mechanisms at play, can be divided into inflammasomopathies, interferonopathies, relopathies, protein misfolding, and endogenous antagonist deficiencies. On the other hand, more common autoinflammatory diseases are multifactorial, with both genetic and non-genetic factors playing an important role...
March 12, 2024: FEBS Journal
https://read.qxmd.com/read/38465597/relationship-of-perivascular-space-markers-with-incident-dementia-in-cerebral-small-vessel-disease
#7
JOURNAL ARTICLE
Hui Hong, Daniel J Tozer, Hugh S Markus
BACKGROUND: Recent studies, using diffusion tensor image analysis along the perivascular space (DTI-ALPS), suggest impaired perivascular space (PVS) function in cerebral small vessel disease, but they were cross-sectional, making inferences on causality difficult. We determined associations between impaired PVS, measured using DTI-ALPS and PVS volume, and cognition and incident dementia. METHODS: In patients with lacunar stroke and confluent white matter hyperintensities, without dementia at baseline, recruited prospectively in a single center, magnetic resonance imaging was performed annually for 3 years, and cognitive assessments, including global, memory, executive function, and processing speed, were performed annually for 5 years...
March 11, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38465047/the-role-of-epigenetics-and-contributing-impact-of-stress-multigenerational-and-developmental-factors-in-opiate-addiction
#8
REVIEW
Jason Do
Drug addiction is characterized by maladaptive neural plasticity, particularly in vulnerable individuals exposed to drugs of abuse. Epigenetic factors include environmental influences, events during development, and stress adaptations, which seem to play an important role in the neuropathogenesis of drug addiction. This critical review hypothesizes that epigenetic modulation increases an individual's susceptibility to opiate addiction in three key areas of epigenetic study: developmental, stress-related, and transgenerational effects...
February 2024: Curēus
https://read.qxmd.com/read/38463990/opposing-motor-memories-in-the-direct-and-indirect-pathways-of-the-basal-ganglia
#9
Kailong Wen, Zhuoyue Shi, Peijia Yu, Lillian Mo, Shivang Sullere, Victor Yang, Nate Westneat, Jeff A Beeler, Daniel S McGehee, Brent Doiron, Xiaoxi Zhuang
Loss of dopamine neurons causes motor deterioration in Parkinson's disease patients. We have previously reported that in addition to acute motor impairment, the impaired motor behavior is encoded into long-term memory in an experience-dependent and task-specific manner, a phenomenon we refer to as aberrant inhibitory motor learning. Although normal motor learning and aberrant inhibitory learning oppose each other and this is manifested in apparent motor performance, in the present study, we found that normal motor memory acquired prior to aberrant inhibitory learning remains preserved in the brain, suggesting the existence of independent storage...
February 28, 2024: bioRxiv
https://read.qxmd.com/read/38460374/regulation-of-histone-acetylation-by-garcinol-blocks-the-reconsolidation-of-heroin-associated-memory
#10
JOURNAL ARTICLE
Junzhe Cheng, Binbin Wang, Hongkun Hu, Xinzhu Lin, Yuhang Liu, Jiang Lin, Jinlong Zhang, Shuliang Niu, Jie Yan
Drug-associated long-term memories underlie substance use disorders, including heroin use disorder (HUD), which are difficult to eliminate through existing therapies. Addictive memories may become unstable when reexposed to drug-related cues and need to be stabilized again through protein resynthesis. Studies have shown the involvement of histone acetylation in the formation and reconsolidation of long-term drug-associated memory. However, it remains unknown whether and how histone acetyltransferases (HAT), the essential regulators of histone acetylation, contribute to the reconsolidation of heroin-associated memories...
March 8, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38454052/reactivation-of-encoding-ensembles-in-the-prelimbic-cortex-supports-temporal-associations
#11
JOURNAL ARTICLE
Thays Brenner Santos, Cesar Augusto de Oliveira Coelho, Juliana Carlota Kramer-Soares, Paul W Frankland, Maria Gabriela Menezes Oliveira
Fear conditioning is encoded by strengthening synaptic connections between the neurons activated by a conditioned stimulus (CS) and those activated by an unconditioned stimulus (US), forming a memory engram, which is reactivated during memory retrieval. In temporal associations, activity within the prelimbic cortex (PL) plays a role in sustaining a short-term, transient memory of the CS, which is associated with the US after a temporal gap. However, it is unknown whether the PL has only a temporary role, transiently representing the CS, or is part of the neuronal ensembles that support the retrieval, i...
March 7, 2024: Neuropsychopharmacology
https://read.qxmd.com/read/38453752/an-acute-bout-of-resistance-exercise-increases-bdnf-in-hippocampus-and-restores-the-long-term-memory-of-insulin-resistant-rats
#12
JOURNAL ARTICLE
Camila Berbert-Gomes, Júlia S Ramos, João G Silveira-Rodrigues, Daniel M M Leite, Bruno P Melo, Danusa D Soares
A sedentary lifestyle, inadequate diet, and obesity are substantial risk factors for Type 2 diabetes mellitus (T2DM) development. A major picture of T2DM is insulin resistance (IR), which causes many impairments in brain physiology, such as increased proinflammatory state and decreased brain-derived neurotrophic factor (BDNF) concentration, hence reducing cognitive function. Physical exercise is a non-pharmacological tool for managing T2DM/IR and its complications. Thus, this study investigated the effects of IR induction and the acute effects of resistance exercise (RE) on memory, neurotrophic, and inflammatory responses in the hippocampus and prefrontal cortex of insulin-resistant rats...
March 7, 2024: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://read.qxmd.com/read/38451698/a-lifespan-study-of-the-confidence-accuracy-relation-in-working-memory-and-episodic-long-term-memory
#13
JOURNAL ARTICLE
Nathaniel R Greene, Alicia Forsberg, Dominic Guitard, Moshe Naveh-Benjamin, Nelson Cowan
The relation between an individual's memory accuracy and reported confidence in their memories can indicate self-awareness of memory strengths and weaknesses. We provide a lifespan perspective on this confidence-accuracy relation, based on two previously published experiments with 320 participants, including children aged 6-13, young adults aged 18-27, and older adults aged 65-77, across tests of working memory (WM) and long-term memory (LTM). Participants studied visual items in arrays of varying set sizes and completed item recognition tests featuring 6-point confidence ratings either immediately after studying each array (WM tests) or following a long period of study events (LTM tests)...
March 7, 2024: Journal of Experimental Psychology. General
https://read.qxmd.com/read/38450223/human-brain-activity-and-functional-connectivity-associated-with-verbal-long-term-memory-consolidation-across-1-month
#14
JOURNAL ARTICLE
Catherine W Tallman, Zhishang Luo, Christine N Smith
INTRODUCTION: Declarative memories are initially dependent on the hippocampus and become stabilized through the neural reorganization of connections between the medial temporal lobe and neocortex. The exact time-course of these neural changes is not well established, although time-dependent changes in retrieval-related brain function can be detected across relatively short time periods in humans (e.g., hours to months). METHODS: In a study involving older adults with normal cognition (N = 24), we investigated changes in brain activity and functional connectivity associated with the long-term memory consolidation of verbal material over one month...
2024: Frontiers in Human Neuroscience
https://read.qxmd.com/read/38448754/the-neurocognitive-bases-of-meaningful-intransitive-gestures-a-systematic-review-and-meta-analysis-of-neuropsychological-studies
#15
REVIEW
Josselin Baumard, Alice Laniepce, Mathieu Lesourd, Léna Guezouli, Virginie Beaucousin, Maureen Gehin, François Osiurak, Angela Bartolo
Researchers and clinicians have long used meaningful intransitive (i.e., not tool-related; MFI) gestures to assess apraxia-a complex and frequent motor-cognitive disorder. Nevertheless, the neurocognitive bases of these gestures remain incompletely understood. Models of apraxia have assumed that meaningful intransitive gestures depend on either long-term memory (i.e., semantic memory and action lexicons) stored in the left hemisphere, or social cognition and the right hemisphere. This meta-analysis of 42 studies reports the performance of 2659 patients with either left or right hemisphere damage in tests of meaningful intransitive gestures, as compared to other gestures (i...
March 6, 2024: Neuropsychology Review
https://read.qxmd.com/read/38442748/effects-of-clitorienolactones-from-clitoria-ternatea-root-on-calcium-channel-mediating-hippocampal-long-term-potentiation-in-rats-induced-chronic-cerebral-hypoperfusion
#16
REVIEW
Mohamad Anuar Ahad, Nelson Jeng-Yeou Chear, Muhammad Hazim Abdullah, Tan Ai Fein Ching-Ga, Liao Ping, Shunhui Wei, Vikneswaran Murugaiyah, Zurina Hassan
Chronic cerebral hypoperfusion (CCH) is a common mechanism of acute brain injury due to impairment of blood flow to the brain. Moreover, a prolonged lack of oxygen supply may result in cerebral infarction or global ischemia, which subsequently causes long-term memory impairment. Research on using Clitoria ternatea root extract for treating long-term memory has been studied extensively. However, the bioactive compound contributing to its neuroprotective effects remains uncertain. In the present study, we investigate the effects of clitorienolactone A (CLA) and B (CLB) from the roots of Clitoria ternatea extract on hippocampal neuroplasticity in rats induced by CCH...
March 3, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38437178/charge-localized-retention-and-long-term-memory-enabled-by-cooperating-sterically-confined-molecular-crystallization-with-spiro-fluorene-9-9-xanthene-based-c-sp-3-hindrance
#17
JOURNAL ARTICLE
Jin Wang, He Zhang, Dong Jin, Jun-Qi Han, Jing-Wei Fu, Qin Zhu, Ling-Hai Xie
Charge localization of memory materials plays a crucial role in the endurance and retention ability of organic nonvolatile memory, which is completely opposite from the charge delocalization of high-mobility materials. However, charge transfer of both though-space and through-bond based on molecular design principles still faces challenges. Herein, a nonplanar wide-bandgap semiconductor with C sp 3 -hindrance (DOCH3 -DDPA-SFX) has been designed and synthesized. An effective crystallization effect of self-assembled two-dimensional nanosheets on charge trapping dynamics and kinetics is visualized by Kelvin probe force microscopy (KPFM)...
March 4, 2024: Journal of Physical Chemistry Letters
https://read.qxmd.com/read/38437096/vicomp-video-compensation-for-projector-camera-systems
#18
JOURNAL ARTICLE
Yuxi Wang, Haibin Ling, Bingyao Huang
Projector video compensation aims to cancel the geometric and photometric distortions caused by non-ideal projection surfaces and environments when projecting videos. Most existing projector compensation methods start by projecting and capturing a set of sampling images, followed by an offline compensation model training step. Thus, abundant user effort is required before the users can watch the video. Moreover, the sampling images have little prior knowledge of the video content and may lead to suboptimal results...
March 4, 2024: IEEE Transactions on Visualization and Computer Graphics
https://read.qxmd.com/read/38436908/impact-of-process-interference-on-memory-encoding-and-retrieval-processes-in-dual-task-situations
#19
JOURNAL ARTICLE
Sandra Hensen, Iring Koch, Patricia Hirsch
Dual-tasks at the memory encoding stage have been shown to decrease recall performance and impair concurrent task performance. In contrast, studies on the effect of dual-tasks at the memory retrieval stage observed mixed results. Which cognitive mechanisms are underlying this dual-task interference is still an unresolved question. In the present study, we investigated the influence of a concurrent reaction-time task on the performance in a long-term memory task in two experiments. In Experiment 1, participants performed an auditory-verbal free recall memory task and a visual-manual spatial Stroop task in a single or dual-task condition, either at the encoding or retrieval stage of the memory task...
March 4, 2024: Memory & Cognition
https://read.qxmd.com/read/38432446/csf1r-inhibition-reprograms-tumor-associated-macrophages-to-potentiate-anti-pd-1-therapy-efficacy-against-colorectal-cancer
#20
JOURNAL ARTICLE
Qi Lv, Yishu Zhang, Wen Gao, Juan Wang, Yaowen Hu, Hongqiong Yang, Ying Xie, Yingshan Lv, Heyuan Zhang, Dapeng Wu, Lihong Hu, Junwei Wang
PD-1 blockade therapy has made great breakthroughs in treatment of multiple solid tumors. However, patients with microsatellite-stable (MSS) colorectal cancer (CRC) respond poorly to anti-PD-1 immunotherapy. Although CRC patients with microstatellite instability (MSI) or microsatellite instability-high (MSI-H) can benefit from PD-1 blockade therapy, there are still some problems such as tumor recurrence. Tumor-associated macrophages (TAMs), most abundant immune components in tumor microenvironment (TME), largely limit the therapeutic efficacy of anti-PD-1 against CRC...
March 1, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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