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Statistics in Oncology

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https://www.readbyqxmd.com/read/28811996/experimental-method-and-statistical-analysis-to-fit-tumor-growth-model-using-spect-ct-imaging-a-preclinical-study
#1
Ivan Hidrovo, Joyoni Dey, Megan E Chesal, Dmytro Shumilov, Narayan Bhusal, J Michael Mathis
BACKGROUND: Over the last decade, several theoretical tumor-models have been developed to describe tumor growth. Oncology imaging is performed using various modalities including computed tomography (CT), magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT) and fluorodeoxyglucose-positron emission tomography (FDG-PET). Our goal is to extract useful, otherwise hidden, quantitative biophysical parameters (such as growth-rate, tumor-necrotic-factor, etc.) from these serial images of tumors by fitting mathematical models to images...
June 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28808765/presentation-and-symptom-interval-in-children-with-central-nervous-system-tumors-a-single-center-experience
#2
Chiara Stocco, Chiara Pilotto, Eva Passone, Agostino Nocerino, Raffaello Tosolini, Anna Pusiol, Paola Cogo
PURPOSE: The aim of this study is to describe the symptoms and signs of central nervous system (CNS) tumors in a pediatric population and to assess the time interval between the onset of the disease and the time of the diagnosis. METHODS: A retrospective observational study was conducted at our Oncology Pediatric Unit between January 2000 and November 2011. We included 75 children between 5 months and 16 years (mean age of 7.8 ± 4.7 years), with male to female ratio of 3:2...
August 14, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28807698/-cross-cultural-adaptation-and-psychometric-evaluation-of-the-turkish-version-of-the-cancer-behavior-inventory-brief-version
#3
Emine Iyigun, Sevinc Tastan, Elif Gezginci, Serap Korkmaz, Selcuk Demiral, Murat Beyzadeoglu
CONTEXT: Cancer Behavior Inventory-Brief Version is a simple and non-burdensome tool used to evaluate the self-efficacy of the cancer patients. OBJECTIVES: The aim of this study was to examine the psychometric properties of the Turkish version of the Cancer Behavior Inventory-Brief Version. METHODS: This methodological study was conducted on 143 cancer patients who received radiotherapy at the Department of Radiation Oncology at a Training and Research Hospital in Turkey...
August 11, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28807031/inflammation-and-pro-resolution-inflammation-after-hepatobiliary-surgery
#4
Juan P Cata, Jose F Velasquez, Maria F Ramirez, Jean-Nicolas Vauthey, Vijaya Gottumukkala, Claudius Conrad, Bradford J Kim, Thomas Aloia
BACKGROUND: The magnitude of the perioperative inflammatory response plays a role in surgical outcomes. However, few studies have explored the mechanisms of the resolution of inflammation in the context of surgery. Here, we described the temporal kinetics of interleukin-6, cortisol, lipoxin A4, and resolvin D in patients who underwent oncologic liver resections. METHODS: All patients gave written informed consent. Demographic and perioperative surgical data were collected, along with blood samples, before surgery and on the mornings of postoperative days 1, 3, and 5...
August 10, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28804898/epilepsy-surgery-of-low-grade-epilepsy-associated-neuroepithelial-tumors-a-retrospective-nationwide-italian-study
#5
Marco Giulioni, Gianluca Marucci, Veronica Pelliccia, Francesca Gozzo, Carmen Barba, Giuseppe Didato, Flavio Villani, Giancarlo Di Gennaro, Pier Paolo Quarato, Vincenzo Esposito, Alessandro Consales, Matteo Martinoni, Gianfranco Vornetti, Corrado Zenesini, Carlo Efisio Marras, Nicola Specchio, Luca De Palma, Raffaele Rocchi, Flavio Giordano, Giovanni Tringali, Paolo Nozza, Gabriella Colicchio, Guido Rubboli, Giorgio Lo Russo, Renzo Guerrini, Paolo Tinuper, Francesco Cardinale, Massimo Cossu
OBJECTIVE: To analyze the attitude and results of Italian epilepsy surgery centers in the surgical management of "low grade epilepsy associated neuroepithelial tumors" (LEATs). METHODS: We conducted a retrospective study enrolling 339 consecutive patients with LEATs who underwent surgery between January 2009 and June 2015 at eight Italian epilepsy surgery centers. We compared demographic, clinical, pathologic, and surgical features of patients with favorable (Engel class I) and unfavorable (Engel class II, III, and IV) seizure outcome...
August 14, 2017: Epilepsia
https://www.readbyqxmd.com/read/28802887/clinical-outcomes-of-patients-with-t1-nested-variant-of-urothelial-carcinoma-compared-to-pure-urothelial-carcinoma-of-the-bladder
#6
Abhijith D Mally, Amy L Tin, Justin K Lee, Prassannah Satasivam, Eugene K Cha, S Michele Donat, Harry W Herr, Bernard H Bochner, Daniel D Sjoberg, Guido Dalbagni
PURPOSE: Evaluate oncologic outcomes of patients with cT1 nested variant (NV) of urothelial carcinoma (UC) and compare with cases of pure UC of the bladder. MATERIALS AND METHODS: We retrospectively identified 30 patients with NV who, between 1997 and 2012, underwent transurethral resection with T1 tumor stage, followed by restaging transurethral resection within 3 months confirming non-muscle-invasive disease. Radical cystectomy within 3 months of restaging transurethral resection was considered "early" treatment...
July 14, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28801116/comparative-results-of-three-short-brachytherapy-schedules-as-exclusive-treatment-in-postoperative-endometrial-carcinoma
#7
Ángeles Rovirosa, Antonio Herreros, Cristina Camacho, Carlos Ascaso, Joan Sánchez, Stepphania Cortés, Sebastià Sabater, Jordi Solà, Aureli Torné, Meritxell Arenas
PURPOSE: To compare vaginal control and treatment toxicity of three different high-dose-rate brachytherapy schedules as exclusive treatment in postoperative endometrial carcinoma. METHODS AND MATERIALS: From 2003 to 2015, three different schedules were used as postoperative treatment for 146 patients (p) with intermediate-risk endometrial carcinoma. Group 1 (41 p): six fractions of 4-6 Gy, 3-4 fractions per week; Group 2 (59 p): four fractions of 5-6 Gy administered daily; Group 3 (46 p): 6 Gy × 3 fractions in three consecutive days...
August 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28800943/genetic-consultation-embedded-in-a-gynecologic-oncology-clinic-improves-compliance-with-guideline-based-care
#8
Leigha Senter, David M O'Malley, Floor J Backes, Larry J Copeland, Jeffery M Fowler, Ritu Salani, David E Cohn
OBJECTIVE: Analyze the impact of embedding genetic counseling services in gynecologic oncology on clinician referral and patient uptake of cancer genetics services. METHODS: Data were reviewed for a total of 737 newly diagnosed epithelial ovarian cancer patients seen in gynecologic oncology at a large academic medical center including 401 from 11/2011-7/2014 (a time when cancer genetics services were provided as an off-site consultation). These data were compared to data from 8/2014-9/2016 (n=336), when the model changed to the genetics embedded model (GEM), incorporating a cancer genetic counselor on-site in the gynecologic oncology clinic...
August 8, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28796935/focal-irreversible-electroporation-as-primary-treatment-for-localized-prostate-cancer
#9
Willemien van den Bos, Matthijs J Scheltema, Amila R Siriwardana, Anton M F Kalsbeek, James E Thompson, Francis Ting, Maret Böhm, Anne-Maree Haynes, Ron Shnier, Warick Delprado, Phillip D Stricker
OBJECTIVES: To determine the safety, quality of life (QoL) and short-term oncological outcomes of primary focal IRE for the treatment of localized prostate cancer. To identify potential risk factors for oncological failure. PATIENTS AND METHODS: Patients that met both the consensus guidelines on patient criteria and selection methods for primary focal therapy were eligible for analysis. Focal IRE was performed for organ-confined clinically significant PCa, being high-volume Gleason sum score 6 (ISUP grade 1) or any Gleason sum score 7 (ISUP grade 2-3)...
August 10, 2017: BJU International
https://www.readbyqxmd.com/read/28796559/improvements-in-patient-and-health-system-outcomes-using-an-integrated-oncology-and-palliative-medicine-approach-on-a-solid-tumor-inpatient-service
#10
Richard F Riedel, Kim Slusser, Steve Power, Christopher A Jones, Thomas W LeBlanc, Arif H Kamal, Devi Desai, Deborah Allen, Yinxi Yu, Steven Wolf, Anthony N Galanos
PURPOSE: Early palliative care (PC) improves outcomes for outpatients with advanced cancer. Its effect on hospitalized patients with cancer is unknown. Herein, we report on the influence of a novel, fully integrated inpatient medical oncology and PC partnership at a tertiary medical center during its first year of implementation. METHODS: We conducted a retrospective, longitudinal, pre- and postintervention cohort study at Duke University Hospital. Pre- and postintervention cohorts were defined as all patients admitted to the solid tumor inpatient service from September 1, 2009, to June 30, 2010, and September 1, 2011 to June 30, 2012, respectively...
August 10, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28795243/there-is-no-difference-in-outcome-between-laparoscopic-and-open-surgery-for-rectal-cancer-a-systematic-review-and-meta-analysis-on-short-and-long-term-oncologic-outcomes
#11
REVIEW
M Pędziwiatr, P Małczak, M Mizera, J Witowski, G Torbicz, P Major, M Pisarska, M Wysocki, A Budzyński
BACKGROUND: Until recently there has been little data available about long-term outcomes of laparoscopic rectal cancer surgery. But new randomized controlled trials regarding laparoscopic colorectal surgery have been published. The aim of this study was to compare the short- and long-term oncologic outcomes of laparoscopy and open surgery for rectal cancer through a systematic review of the literature and a meta-analysis of relevant RCTs. METHODS: A systematic review of Medline, Embase and the Cochrane library from January 1966 to October 2016 with a subsequent meta-analysis was performed...
August 9, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28776964/a-modified-edmonton-symptom-assessment-scale-for-symptom-clusters-in-radiation-oncology-patients
#12
Peter A S Johnstone, Jae Lee, Jun-Min Zhou, Zhenjun Ma, Diane Portman, Heather Jim, Hsiang-Hsuan Michael Yu
Patient-reported outcomes regarding symptom burden may provide valuable information in addition to physician assessment. Systematic collection of patient-reported outcomes may be an important metric to identify unmet needs and improve quality of patient care. To understand common symptoms of patients seen in radiation oncology clinic, we examined the prospectively collected modified Edmonton Symptom Assessment Scale (ESAS-r) data to explore symptom clusters. Our clinic established use of a modified Edmonton Symptom Assessment Scale in August 2015...
August 4, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28776893/preoperative-medication-use-and-its-association-with-postoperative-length-of-hospital-stay-in-surgical-oncology-patients-receiving-comprehensive-geriatric-assessment
#13
Young Mi Jeong, Kyung Eun Lee, Eun Sook Lee, Kwang Ill Kim, Jee Eun Chung, Byung Koo Lee, Hye Sun Gwak
AIM: The present study aimed to investigate whether preoperative medication use is associated with postoperative length of hospital stay in older adults undergoing cancer surgery. METHODS: Patients aged ≥65 years who were scheduled for cancer surgery and presented for preoperative comprehensive geriatric assessment were included in the present study. Cognitive function evaluation and preoperative medication review were carried out, as well as baseline characteristics of participants collected from electronic medical records...
August 4, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28776088/impact-of-partial-volume-correction-in-oncological-pet-studies-a-systematic-review-and-meta-analysis
#14
Matthijs C F Cysouw, Gerbrand M Kramer, Linda J Schoonmade, Ronald Boellaard, Henrica C W de Vet, Otto S Hoekstra
PURPOSE: Positron-emission tomography can be useful in oncology for diagnosis, (re)staging, determining prognosis, and response assessment. However, partial-volume effects hamper accurate quantification of lesions <2-3× the PET system's spatial resolution, and the clinical impact of this is not evident. This systematic review provides an up-to-date overview of studies investigating the impact of partial-volume correction (PVC) in oncological PET studies. METHODS: We searched in PubMed and Embase databases according to the PRISMA statement, including studies from inception till May 9, 2016...
August 4, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28769578/cost-of-illness-of-urothelial-bladder-cancer-in-italy
#15
Claudio Gerace, Francesco Montorsi, Rosa Tambaro, Giacomo Cartenì, Stefano De Luca, Marcello Tucci, Giuseppe Martorana, Umberto Basso, Leonardo Cardosi, Cristina Teruzzi
BACKGROUND: Urothelial bladder cancer (UBC) is the ninth most common cancer worldwide. In Italy, the prevalence of the disease is approximately 10%, making it the fourth most prevalent cancer in the country. The increase in prevalence requires continuous surveillance and care, resulting in a significant burden on Italian National Health Service, making any improvement to the strategy for diagnosing and treating this disease important to the medical and scientific community. The aim of this study was to evaluate the UBC cost of illness in the Italian context, collecting the total costs of the disease...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28764757/how-accurate-is-the-surprise-question-at-identifying-patients-at-the-end-of-life-a-systematic-review-and-meta-analysis
#16
Nicola White, Nuriye Kupeli, Victoria Vickerstaff, Patrick Stone
BACKGROUND: Clinicians are inaccurate at predicting survival. The 'Surprise Question' (SQ) is a screening tool that aims to identify people nearing the end of life. Potentially, its routine use could help identify patients who might benefit from palliative care services. The objective was to assess the accuracy of the SQ by time scale, clinician, and speciality. METHODS: Searches were completed on Medline, Embase, CINAHL, AMED, Science Citation Index, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Open Grey literature (all from inception to November 2016)...
August 2, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28761069/evidence-for-treatment-by-biomarker-interaction-for-fda-approved-oncology-drugs-with-required-pharmacogenomic-biomarker-testing
#17
Alexandre Vivot, Isabelle Boutron, Geoffroy Béraud-Chaulet, Jean-David Zeitoun, Philippe Ravaud, Raphaël Porcher
For oncology drugs that were approved by the US Food and Drug Administration (FDA) and required pharmacogenomic biomarker testing, we describe 1) the use of enrichment (biomarker-positive patients) and a randomized controlled design by pre-approval trials and 2) the treatment-by-biomarker interaction. From the 137 drugs included in the FDA table, we selected the 22 oncology drugs with required genetic testing in their labels. These drugs corresponded to 35 approvals supported by 80 clinical studies included in the FDA medical officer reviews of efficacy...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28759542/video-assisted-thoracoscopic-versus-robotic-assisted-thoracoscopic-thymectomy-systematic-review-and-meta-analysis
#18
Matthew Fok, Mohamad Bashir, Amer Harky, David Sladden, Mariano DiMartino, Hazim Elsyed, Callum Howard, Maxwell Knipe, Michael J Shackcloth
OBJECTIVE: Minimally invasive thoracic surgical procedures, performed with or without the assistance of a robot, have gained popularity over the last decade. They have increasingly become the choice of intervention for a number of thoracic surgical operations. Minimally invasive surgery decreases postoperative pain, hospital stay and leads to a faster recovery in comparison with conventional open methods. Minimally invasive techniques to perform a thymectomy include video-assisted thoracoscopic surgery (VATS) or robotic-assisted thoracoscopic surgery (RATS)...
July 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/28758757/-colorectal-cancer-in-senior-patients-are-we-doing-it-well
#19
D Kostrouch, L Martínek, J Hoch
INTRODUCTION: Geriatric patients form a significant part of patients with colorectal cancer and their numbers will probably continue to increase. Analysis of the quality of care provided to seniors and the results from their treatment are currently gaining more attention. The aim of this study was to compare how often standard oncological therapy is administered to seniors with colorectal cancer and to compare their results with younger patients along with complications of the therapy...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28753820/clinical-lymphadenopathy-in-urothelial-cancer-a-transatlantic-collaboration-on-performance-of-cross-sectional-imaging-and-oncologic-outcomes-in-patients-treated-with-radical-cystectomy-without-neoadjuvant-chemotherapy
#20
Marco Moschini, Alessandro Morlacco, Alberto Briganti, Brian Hu, Renzo Colombo, Francesco Montorsi, Igor Frank, Siamak Daneshmand, R Jeffrey Karnes
BACKGROUND: Data regarding clinical node metastases (cN+) in patients undergoing radical cystectomy (RC) are scarce. OBJECTIVE: To evaluate the performance of conventional imaging in detecting cN+ and analyze the impact of cN+ on survival among patients treated with RC without neoadjuvant chemotherapy (NAC). DESIGN, SETTING, AND PARTICIPANTS: Data from three independent centers of consecutive patients with bladder cancer treated with RC without NAC were analyzed...
November 23, 2016: European Urology Focus
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