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Statistics in Oncology

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https://www.readbyqxmd.com/read/29348902/feasibility-and-outcome-of-primary-laparoscopic-cytoreductive-surgery-for-advanced-epithelial-ovarian-cancer-a-comparison-to-laparotomic-surgery-in-retrospective-cohorts
#1
Huamao Liang, Hongyan Guo, Chunyu Zhang, FuLi Zhu, Yu Wu, Kun Zhang, Hua Li, Jinsong Han
Objectives: To assess the feasibility and outcome of primary laparoscopic cytoreductive surgery on advanced epithelial ovarian cancer in comparison with conventional open surgery. Materials and Methods: Patients undergoing primary laparoscopic cytoreductive surgery (LCS) from March 2007 to December 2016 were matched to controls treated with laparotomic cytoreduction during the same period. Procedural data and outcomes were analyzed. Results: The LCS group (n = 64) and laparotomic group (n = 68) had similar age, BMI, stages, histologic type and grading...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29345722/morphometric-properties-of-the-tensor-fascia-lata-muscle-in-human-fetuses
#2
Orhan Beger, Turan Koç, Burhan Beger, Deniz Uzmansel, Zeliha Kurtoğlu
In neonatal and early childhood surgeries such as meningomyelocele repairs, closing deep wounds and oncological treatment, tensor fasciae lata (TFL) flaps are used. However, there are not enough data about structural properties of TFL in fetuses, which can be considered as the closest to neonates in terms of sampling. This study's main objective is to gather data about morphological structures of TFL in human fetuses to be used in newborn surgery. Fifty formalin-fixed fetuses (24 Male - 26 Female) with gestational age ranging from 18 - 30 weeks (mean 22...
January 18, 2018: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29344408/differential-research-impact-in-cancer-practice-guidelines-evidence-base-lessons-from-esmo-nice-and-sign
#3
Elena Pallari, Anthony W Fox, Grant Lewison
Background: This is an appraisal of the impact of cited research evidence underpinning the development of cancer clinical practice guidelines (CPGs) by the professional bodies of the European Society for Medical Oncology (ESMO), the National Institute for Health and Care Excellence (NICE) and the Scottish Intercollegiate Guidelines Network (SIGN). Methods: A total of 101 CPGs were identified from ESMO, NICE and SIGN websites across 13 cancer sites. Their 9486 cited references were downloaded from the Web of Science Clarivate Group database, analysed on Excel (2016) using Visual Basic Application macros and imported onto SPSS (V...
2018: ESMO Open
https://www.readbyqxmd.com/read/29343302/does-previous-abdominal-surgery-adversely-affect-perioperative-and-oncologic-outcomes-of-laparoscopic-radical-cystectomy
#4
Xiaosong Wei, Jinjin Lu, Khurram Mutahir Siddiqui, Fan Li, Qianyuan Zhuang, Weimin Yang, Zhiquan Hu, Zhong Chen, Xiaodong Song, Shaogang Wang, Zhangqun Ye
BACKGROUND: Laparoscopic radical cystectomy (LRC) has been shown to have less estimated blood loss (EBL), transfusion rate, narcotic analgesic requirement, earlier return of bowel function, and shorter hospital stay. The aim of this study was to investigate the feasibility, peri-operative and oncologic outcomes of laparoscopic radical cystectomy (LRC) in patients with previous abdominal surgery (PAS). METHODS: We retrospectively reviewed 243 patients undergoing open radical cystectomy (ORC) or LRC with bilateral pelvic lymph node dissection and urinary diversion or cutaneous ureterostomy at a single center from January 2010 to December 2015...
January 17, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29342465/de-novo-bladder-urothelial-neoplasm-in-renal-transplant-recipients-a-retrospective-multicentered-study
#5
Anna Palazzetti, Andrea Bosio, Ettore Dalmasso, Paolo Destefanis, Fabrizio Fop, Francesca Pisano, Giuseppe Segoloni, Luigi Biancone, Alessandro Volpe, Antonia Di Domenico, Carlo Terrone, Samuele Iesari, Antonio Famulari, Paola Todeschini, Bruno Frea, Paolo Gontero
BACKGROUND AND OBJECTIVES: Renal transplant recipients (RTRs) have a 2- to 7-fold risk of developing a neoplasm compared to general population. Bladder urothelial neoplasms in this cohort has an incidence of 0.4-2%. Many reports describe a more aggressive behavior. The objective of this study is to describe oncologic characteristics of bladder urothelial neoplasms in RTRs and to evaluate its recurrence, progression, and survival rates. METHODS: A retrospective multicentered study was performed evaluating all de novo bladder urothelial neoplasms cases in RTRs from 1988 to 2014...
January 17, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29340992/prospective-comparative-study-of-laparoscopic-narrow-band-imaging-nbi-versus-standard-imaging-in-gynecologic-oncology
#6
Alessia Aloisi, Yukio Sonoda, Ginger J Gardner, Kay J Park, Sarah L Elliott, Qin C Zhou, Alexia Iasonos, Nadeem R Abu-Rustum
BACKGROUND: Narrow band imaging (NBI) is an optic filtration enhancement for endoscopy that uses two wavelengths of light (415 and 540 nm) to highlight superficial microvascular patterns. It has been successfully utilized to improve identification of lesions with abnormal vasculature, which is associated with endometriosis and endometrial cancer. Case studies suggest it may also facilitate surgical staging of gynecologic cancer, which is critical in determining appropriate adjuvant therapies...
January 16, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29340112/incidence-and-relative-risk-of-peripheral-neuropathy-in-cancer-patients-treated-with-eribulin-a-meta-analysis
#7
Ling Peng, Yun Hong, Xianghua Ye, Peng Shi, Junyan Zhang, Yina Wang, Qiong Zhao
Background: Eribulin is a microtubule inhibitor, which is approved for the treatment of breast cancer. Peripheral neuropathy has been reported in the studies of eribulin, but the incidence and relative risk (RR) of eribulin-associated peripheral neuropathy varied greatly in cancer patients. The purpose of this meta-analysis was to determine the overall incidence and RR of eribulin-associated peripheral neuropathy in cancer patients. Materials and Methods: Pubmed database and Embase and abstracts presented at the American Society of Clinical Oncology (ASCO) meetings were systematically reviewed for primary studies...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339653/adherence-to-the-european-association-of-urology-guidelines-a-national-survey-among-italian-urologists
#8
Giovanni Cacciamani, Walter Artibani, Alberto Briganti, James N'Dow
OBJECTIVE: The study aimed to explore adherence to the European Urological Association (EAU) Guidelines (GLs) grade A recommendation among Italian urologists. MATERIALS AND METHODS: A 13-item multiple-choice questionnaire covering oncological and non-oncological urological diseases was e-mailed to all Italian Urologist Society (Società Italiana di Urologia or SIU) members. We asked members to provide an explanation for their answer choice where needed. The quantitative data were tested using the Pearson's chi-square test...
January 16, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29339575/dynamic-pet-image-reconstruction-integrating-temporal-regularization-associated-with-respiratory-motion-correction-for-applications-in-oncology
#9
Thibaut Merlin, Dimitris Visvikis, Philippe Fernandez, Frederic Lamare
Respiratory motion reduces both the qualitative and quantitative accuracy of PET images in oncology. This impact is more significant for quantitative applications based on kinetic modeling, where dynamic acquisitions are associated with limited statistics due to the necessity of enhanced temporal resolution. The aim of this study is to address these drawbacks by combining within a unique reconstruction algorithm in dynamic PET imaging, a respiratory motion correction approach, as well as a temporal regularization...
January 17, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29338980/prevalence-of-bovine-aortic-arch-variant-in-patients-with-aortic-dissection-and-its-implications-in-the-outcome-of-patients-with-acute-type-b-aortic-dissection
#10
Spyridon N Mylonas, Arthurs Barkans, Marius Ante, Jens Wippermann, Dietmar Böckler, Jan Sigge Brunkwall
OBJECTIVE/BACKGROUND: To investigate the prevalence of bovine arch (BA) among patients with type A and B aortic dissection, and to provide insight into the implication of this variation on the outcome of patients with acute or subacute type B aortic dissection (a/sTBAD). METHODS: This retrospective cohort analysis includes patients with a/sTBAD admitted between January 2006 and December 2016. Computed tomographic angiograms (CTAs) of patients referred because of type A aortic dissection were also re-evaluated with regard to the presence of BA...
January 12, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29338904/pain-and-its-impact-on-the-functional-ability-in-children-treated-at-the-children-s-cancer-center-of-lebanon
#11
Dina Madi, Michael Clinton
PURPOSE: The purpose of this study was to describe the characteristics of pain in children under treatment at the Children Cancer Centre of Lebanon at the American University of Beirut Medical Centre. Design and Methods A cross-sectional correlational survey was used. The Adolescent Pediatric Pain Tool and the Functional Disability Inventory were used to examine the characteristics of pain experienced in a consecutive sample of children treated at the CCCL and its impact on their functional abilities...
January 12, 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29338572/implementation-of-additional-prescribing-authorization-among-oncology-pharmacists-in-alberta
#12
Bianca Au, Deonne Dersch-Mills, Sunita Ghosh, Jennifer Jupp, Carole Chambers, Frances Cusano, Melanie Danilak
Purpose To describe the practice settings and prescribing practices of oncology pharmacists with additional prescribing authorization. Methods A descriptive, cross-sectional survey of all oncology pharmacists in Alberta was conducted using a web-based questionnaire over four weeks between March and April 2016. Pharmacists were identified from the Cancer Services Pharmacy Directory and leadership staff in Alberta Health Services. Descriptive statistics were used to describe the practice setting, prescribing practices, motivators to apply for additional prescribing authorization, and the facilitators and barriers of prescribing...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29334304/switching-from-laparoscopic-radical-prostatectomy-to-robot-assisted-laparoscopic-prostatectomy-comparing-oncological-outcomes-and-complications
#13
Ida Johnson, Fredrik Ottosson, Lien My Diep, Rolf Eigil Berg, Jon-Roar Hoff, Nicolai Wessel, Lars Magne Eri, Viktor Berge
OBJECTIVES: To compare oncological outcomes and complication rates based on the Clavien classification between laparoscopic radical prostatectomies (LRP) and robot-assisted laparoscopic radical prostatectomies (RALP). MATERIAL AND METHODS: In a prospective quality registry clinical data were consecutively entered for 544 LRP and 1081 RALP patients operated from 2003 to the end of 2012. Complications within 90 days postoperatively were assessed according to the Clavien classification and compared between LRP and RALP patients...
January 15, 2018: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/29333006/rational-use-of-imaging-to-stage-breast-cancer-evidences-for-a-selective-approach
#14
S G D Gangadaran
Introduction: Staging investigations at diagnosis are customary to accurately assign a clinical stage before therapy. The practice of routine imaging in patients asymptomatic for metastasis is not recommended but widely adopted. This study was done to reexamine the basis behind guideline recommendations and to identify the factors predictive of asymptomatic metastasis. Methods: Oncology records of 200 breast cancer patients in clinical Stages I-III at diagnosis were prospectively reviewed...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29332504/changes-in-distress-measured-by-the-distress-thermometer-as-reported-by-patients-in-home-palliative-care-in-germany
#15
Stefanie Ohnhäuser, Johannes Wüller, Ann Christina Foldenauer, Tania Pastrana
AIM: To identify changes in distress as reported by patients in a home palliative care program over a 2-week period. METHODS: Prospective study in West Germany with consecutive patients cared for at home by a palliative care specialty team. Exclusion criteria were patients under 18 years of age, mentally or physically not able to complete the assessment questionnaires, or unable to comprehend German language. Distress was measured using the distress thermometer (DT); sociodemographic and medical data were collected from the patients' records...
January 1, 2018: Journal of Palliative Care
https://www.readbyqxmd.com/read/29329992/eus-elastography-strain-ratio-and-fractal-based-quantitative-analysis-for-the-diagnosis-of-solid-pancreatic-lesions
#16
Silvia Carrara, Milena Di Leo, Fabio Grizzi, Loredana Correale, Rahal Daoud, Andrea Anderloni, Francesco Auriemma, Alessandro Fugazza, Paoletta Preatoni, Roberta Maselli, Cesare Hassan, Elena Finati, Benedetto Mangiavillano, Alessandro Repici
BACKGROUND AND AIMS: EUS elastography is useful in characterizing solid pancreatic lesions (SPLs), and fractal analysis-based technology has been used to evaluate geometric complexity in oncology. The aim of this study was to evaluate EUS elastography (strain ratio) and fractal analysis for the characterization of SPLs. METHODS: Consecutive patients with SPLs were prospectively enrolled between December 2015 and February 2017. Elastographic evaluation included parenchymal strain ratio (pSR) and wall strain ratio (wSR) and was performed with the EU-ME2 processor (Olympus)...
January 9, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29321020/meta-analysis-of-human-gene-expression-in-response-to-mycobacterium-tuberculosis-infection-reveals-potential-therapeutic-targets
#17
Zhang Wang, Seda Arat, Michal Magid-Slav, James R Brown
BACKGROUND: With the global emergence of multi-drug resistant strains of Mycobacterium tuberculosis, new strategies to treat tuberculosis are urgently needed such as therapeutics targeting potential human host factors. RESULTS: Here we performed a statistical meta-analysis of human gene expression in response to both latent and active pulmonary tuberculosis infections from nine published datasets. We found 1655 genes that were significantly differentially expressed during active tuberculosis infection...
January 10, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29319926/the-role-of-lymph-node-dissection-in-the-management-of-renal-cell-carcinoma-a-systematic-review-and-meta-analysis
#18
REVIEW
Bimal Bhindi, Christopher J D Wallis, Stephen A Boorjian, R Houston Thompson, Ann Farrell, Simon P Kim, Jose A Karam, Umberto Capitanio, Dragan Golijanin, Bradley C Leibovich, Boris Gershman
OBJECTIVES: To evaluate the role of retroperitoneal lymph node dissection (LND) in non-metastatic (M0) and metastatic (M1) renal cell carcinoma (RCC). PATIENTS AND METHODS: We searched Medline, EMBASE, Web of Science, and Scopus from database inception to August 29, 2017 for studies of patients who underwent partial or radical nephrectomy for M0 or M1 RCC. Two investigators independently selected studies for inclusion. Risk of bias was assessed using the Newcastle-Ottawa scale, Cochrane Collaboration tool, and NHLBI Quality Assessment Tool...
January 10, 2018: BJU International
https://www.readbyqxmd.com/read/29316106/robotic-assisted-radical-cystectomy-with-intracorporeal-urinary-diversion-versus-open-early-australian-experience
#19
Ken Chow, Homayoun Zargar, Niall M Corcoran, Anthony J Costello, Justin S Peters, Philip Dundee
BACKGROUND: The aim of this study was to describe our initial Australian single surgeon experience with robotic-assisted radical cystectomy (RARC) and intracorporeal urinary diversion (ICUD) and to compare the outcomes with open radical cystectomy (ORC). METHODS: Between January 2014 and June 2016, consecutive patients diagnosed with muscle invasive and high-risk non-muscle invasive bladder cancer undergoing radical cystectomy were included. Treatment modalities included either RARC with ICUD or ORC...
January 8, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29313248/functional-outcomes-with-handsewn-versus-stapled-anastomoses-in-the-treatment-of-ultralow-rectal-cancer
#20
Lisa Ramage, Paul Mclean, Constantinos Simillis, Shengyang Qiu, Christos Kontovounisios, Emile Tan, Paris Tekkis
Adequate oncological outcomes have been demonstrated with rectal resection and handsewn coloanal anastomosis (CAA) in tumours in close proximity to the internal anal sphincter. Our aim was to assess functional differences between handsewn CAA and ultralow stapled anastomosis. Participants were identified from a single-surgeon series. Included participants underwent anorectal physiology testing of anal sphincter function, in addition to completion of several questionnaires: Wexner Incontinence Score (WIS); Birmingham Bowel, Bladder and Urinary Symptom Questionnaire (BBUSQ); Low Anterior Resection Syndrome (LARS) Score; SF36...
January 8, 2018: Updates in Surgery
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