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https://www.readbyqxmd.com/read/28431457/precision-medicine-and-pharmacogenetics-what-does-oncology-have-that-addiction-medicine-does-not
#1
Henry R Kranzler, Rachel V Smith, Robert Schnoll, Afaf Moustafa, Emma Greenstreet-Akman
BACKGROUND AND AIMS: Precision, personalized or stratified medicine, which promises to deliver the right treatment to the right patient, is a topic of international interest in both the lay press and the scientific literature. A key aspect of precision medicine is the identification of biomarkers that predict the response to medications (i.e. pharmacogenetics). We examined why, despite the great strides that have been made in biomarker identification in many areas of medicine, only in oncology has there been substantial progress in their clinical implementation...
April 21, 2017: Addiction
https://www.readbyqxmd.com/read/28431212/dna-barcoding-and-traditional-taxonomy-an-integrated-approach-for-biodiversity-conservation
#2
Bhavisha P Sheth, Vrinda S Thaker
Biological diversity is depleting at an alarming rate. Additionally, a vast amount of biodiversity still remains undiscovered. Taxonomy has been serving the purpose of describing, naming, and classifying species for more than 250 years. DNA taxonomy and barcoding have accelerated the rate of this process, thereby providing a tool for conservation practice. DNA barcoding and traditional taxonomy have their own inherent merits and demerits. The synergistic use of both methods, in the form of integrative taxonomy, has the potential to contribute to biodiversity conservation in a pragmatic timeframe and overcome their individual drawbacks...
April 21, 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28431209/drug-delivery-systems-based-on-hydroxyethyl-starch
#3
Constantinos M Paleos, Zili Sideratou, Dimitris Tsiourvas
Τhe advantageous biological properties of hydroxyethyl starch (HES) triggered research interest towards design and synthesis of Drug Delivery Systems (DDSs) based on this polysaccharide. Convenient reaction schemes, including one-step reactions, led to the synthesis of HES conjugates with selected anticancer molecules or therapeutic proteins. Nanocapsules and hydrogels based on HES were also prepared and studied as prospective drug delivery systems. Formulations originating from these drug conjugates and also from nanocapsules and hydrogels loaded with drugs were characterized, highlighting on the extension of their half-life in plasma which is a critical property as far as their efficacy is concerned...
April 21, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28430626/expression-of-pd-l1-and-prognosis-in-breast-cancer-a-meta-analysis
#4
Minghui Zhang, Houbin Sun, Shu Zhao, Yan Wang, Haihong Pu, Yan Wang, Qingyuan Zhang
The associations between programmed cell death ligand 1 (PD-L1) and the prognosis of various cancers have always been a research topic of considerable interest. However, the prognostic value of PD-L1 in breast cancer patients remains a controversial subject. We aimed to assess the association between PD-L1 protein expression and clinicopathological features and the impact of this relationship on breast cancer survival. We performed a systematic search of the PubMed, EMBASE, and Cochrane Library databases to determine the correlations among PD-L1 expression, clinicopathological features and overall survival (OS)...
February 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430166/-french-phage-network-second-meeting-report
#5
Clara Torres-Barceló, Oliver Kaltz, Rémy Froissart, Sylvain Gandon, Nicolas Ginet, Mireille Ansaldi
The study of bacteriophages (viruses of bacteria) includes a variety of approaches, such as structural biology, genetics, ecology, and evolution, with increasingly important implications for therapeutic and industrial uses. Researchers working with phages in France have recently established a network to facilitate the exchange on complementary approaches, but also to engage new collaborations. Here, we provide a summary of the topics presented during the second meeting of the French Phage Network that took place in Marseille in November 2016...
April 21, 2017: Viruses
https://www.readbyqxmd.com/read/28429885/intravenous-self-administration-of-benzydamine-a-non-steroidal-anti-inflammatory-drug-with-a-central-cannabinoidergic-mechanism-of-action
#6
Riccardo Avvisati, Maria Meringolo, Emiliana Stendardo, Elisa Malavasi, Silvia Marinelli, Aldo Badiani
Benzydamine (BZY) is a non-steroidal anti-inflammatory drug used for the topical treatment of inflammations of the oral and vaginal mucosae. Virtually nothing is known about the central pharmacological actions of BZY. Yet there are reports of voluntary systemic overdosage of BZY in drug addicts, resulting in a euphoric, hallucinatory state. In the present study, we investigated the reinforcing properties of BZY in a rat self-administration paradigm. We found that BZY has a powerful reinforcing effect and that this effect is greatly facilitated in animals that already had substance experience, having previously self-administered heroin and cocaine, indicating cross sensitization between BZY and other common drugs of abuse...
April 21, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28429527/balancing-health-care-education-and-patient-care-in-the-uk-workplace-a-realist-synthesis
#7
Sarah Sholl, Rola Ajjawi, Helen Allbutt, Jane Butler, Divya Jindal-Snape, Jill Morrison, Charlotte Rees
CONTEXT: Patient care activity has recently increased without a proportionate rise in workforce numbers, impacting negatively on health care workplace learning. Health care professionals are prepared in part by spending time in clinical practice, and for medical staff this constitutes a contribution to service. Although stakeholders have identified the balance between health care professional education and patient care as a key priority for medical education research, there have been very few reviews to date on this important topic...
April 20, 2017: Medical Education
https://www.readbyqxmd.com/read/28428978/20th-workshop-of-the-international-stroke-genetics-consortium-november-3-4-2016-milan-italy-2016-036-isgc-research-priorities
#8
Daniel Woo, Stephanie Debette, Christopher Anderson
OBJECTIVE: To develop a research priority list for the International Stroke Genetics Consortium (ISGC). BACKGROUND: Previously, stroke progress review groups and other activities provided an opportunity for members within the field to develop priorities for research. These filtered into larger categories which then published the top research priorities of their given field. However, these review groups are no longer forming and thus there has been no clear direction on what the research priorities and needs for stroke genetics research...
March 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28428164/zika-in-twitter-temporal-variations-of-locations-actors-and-concepts
#9
Anthony Stefanidis, Emily Vraga, Georgios Lamprianidis, Jacek Radzikowski, Paul L Delamater, Kathryn H Jacobsen, Dieter Pfoser, Arie Croitoru, Andrew Crooks
BACKGROUND: The recent Zika outbreak witnessed the disease evolving from a regional health concern to a global epidemic. During this process, different communities across the globe became involved in Twitter, discussing the disease and key issues associated with it. This paper presents a study of this discussion in Twitter, at the nexus of location, actors, and concepts. OBJECTIVE: Our objective in this study was to demonstrate the significance of 3 types of events: location related, actor related, and concept related, for understanding how a public health emergency of international concern plays out in social media, and Twitter in particular...
April 20, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28428163/public-response-to-scientific-misconduct-assessing-changes-in-public-sentiment-toward-the-stimulus-triggered-acquisition-of-pluripotency-stap-cell-case-via-twitter
#10
Alberto Gayle, Motomu Shimaoka
BACKGROUND: In this age of social media, any news-good or bad-has the potential to spread in unpredictable ways. Changes in public sentiment have the potential to either drive or limit investment in publicly funded activities, such as scientific research. As a result, understanding the ways in which reported cases of scientific misconduct shape public sentiment is becoming increasingly essential-for researchers and institutions, as well as for policy makers and funders. In this study, we thus set out to assess and define the patterns according to which public sentiment may change in response to reported cases of scientific misconduct...
April 20, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28427666/the-development-of-recent-high-power-ultrasonic-transducers-for-near-well-ultrasonic-processing-technology
#11
Zhenjun Wang, Yuanming Xu
With the reduction of crude oil throughout the world, enhance oil recovery technology has become a major oil research topics, which can greatly increase the recovery ratio of the crude oil before the dawning of renewable energy era. Near-well ultrasonic processing technology, as one new method, has attracted more attention for Enhanced Oil Recovery due to its low cost, good applicability and no environmental pollution in recent rears. There are two important relevant aspects about Near-well ultrasonic processing technology: (a) how to enhance the oil flow through the rocks into the pumping pool and (b) how to reduce the oil viscosity so that it can be easier to pump...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28427530/phenolic-compounds-and-its-bioavailability-in-vitro-bioactive-compounds-or-health-promoters
#12
Isabel C F R Ferreira, Natália Martins, Lillian Barros
Botanical preparations present a widespread and secular history of use. In fact, natural matrices possess a rich pool of phytochemicals, with promising biological effects. Among them, phenolic compounds have revealed to confer very important attributes to improve the well-being and longevity of worldwide population. Numerous in vitro studies have been carried out evaluating the wide spectrum of bioactivities of phenolic compounds, including its health effects, but through in vivo experiments some of these previous results cannot be properly confirmed, and considerable variations are observed...
2017: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/28427427/association-between-the-ossific-nucleus-and-osteonecrosis-in-treating-developmental-dysplasia-of-the-hip-updated-meta-analysis
#13
Rafal Niziol, Michael Elvey, Evangelia Protopapa, Andreas Roposch
BACKGROUND: A meta-analysis concluded that there was no effect of the femoral head ossification and the incidence of osteonecrosis in the treatment of developmental dysplasia of the hip (DDH), unless only osteonecrosis grades II-IV were considered. The meta-analysis, limited due to the small number of studies available at that time, identified a need for an update as further research emerges. We observed a trend in recent years towards delaying treatment of DDH in the absence of an ossified nucleus...
April 20, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28426988/solar-photocatalytic-application-of-nbo2oh-as-alternative-photocatalyst-for-water-treatment
#14
Luana Márcia Bezerra Batista, Alexsandro Jhones Dos Santos, Djalma Ribeiro da Silva, Ana Paula de Melo Alves, Sergi Garcia-Segura, Carlos Alberto Martínez-Huitle
Water recycling and industrial effluents remediation are a hot topic of research to reduce the environmental impact of the human activity. Persistent organic pollutants are highly recalcitrant compounds with hazardous effects associated to their fate in water bodies. Several novel technologies have been developed during the last decades to deal with this novel contamination. However, the natural sources and idiosyncrasy of each country lead to the potential application of different technologies. In this context, we have focused on the development of phocotalytic treatment of solutions containing dyes using a novel photocatalytic material, the NbO2OH...
April 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28426697/perceived-conflict-of-interest-in-health-science-partnerships
#15
John C Besley, Aaron M McCright, Nagwan R Zahry, Kevin C Elliott, Norbert E Kaminski, Joseph D Martin
University scientists conducting research on topics of potential health concern often want to partner with a range of actors, including government entities, non-governmental organizations, and private enterprises. Such partnerships can provide access to needed resources, including funding. However, those who observe the results of such partnerships may judge those results based on who is involved. This set of studies seeks to assess how people perceive two hypothetical health science research collaborations...
2017: PloS One
https://www.readbyqxmd.com/read/28426521/a-history-of-the-western-institute-of-nursing-and-its-communicating-nursing-research-conferences
#16
Paula A McNeil, Carol A Lindeman
BACKGROUND: The Western Institute of Nursing (WIN) celebrated its 60th anniversary and the 50th Annual Communicating Nursing Research Conference in April 2017. PURPOSE: The purpose of this article is to provide a brief history of the origin, development, and accomplishments of WIN and its Communicating Nursing Research conferences. APPROACH: Historical documents and conference proceedings were reviewed. SUMMARY: WIN was created in 1957 as the Western Council on Higher Education for Nursing under the auspices of the Western Interstate Commission for Higher Education...
April 20, 2017: Nursing Research
https://www.readbyqxmd.com/read/28426304/a-significant-and-quiet-threat-to-public-health-in-the-united-states-state-preemption
#17
Jennifer L Pomeranz, Mark Pertschuk
State and local governments traditionally protect the health and safety of their populations more strenuously than does the federal government. Preemption, when a higher level of government restricts or withdraws the authority of a lower level of government to act on a particular issue, was historically used as a point of negotiation in the legislative process. More recently, however, 3 new preemption-related issues have emerged that have direct implications for public health. First, multiple industries are working on a 50-state strategy to enact state laws preempting local regulation...
April 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28425929/contradictions-and-promise-for-end-of-life-communication-among-family-and-friends-death-over-dinner-conversations
#18
Andrea Lambert South, Jessica Elton
The free, open-access website called "Let's Get Together and Talk about Death", or Death over Dinner (DoD), provides resources for initiating end-of-life conversations with family and friends by taking the frightening-talking about death-and transforming it into the familiar-a conversation over dinner. This qualitative, descriptive study uses grounded theory and thematic analysis to answer the following research question: How do friend and family groups communicate about death and dying in DoD conversations? To answer this question, 52 dinner groups were recruited and conversations were conducted, which consisted of a facilitator and volunteers...
April 20, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28425763/our-panel-of-experts-highlights-the-most-important-research-articles-across-the-spectrum-of-topics-relevant-to-the-field-of-cns-oncology
#19
Larry Junck, Maura Massimino
Expert panel: Larry Junck, University of Michigan Health System, MI, USA; Maura Massimino, Fondazione Istituto di Ricovero & Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy.
April 2017: CNS Oncology
https://www.readbyqxmd.com/read/28423844/identifying-emerging-trends-in-medical-informatics-a-synthesis-approach
#20
Yasmin Van Kasteren, Patricia A H Williams, Anthony Maeder
Medical informatics is a young and rapidly evolving field, influenced by and impacting on many different knowledge domains. Recent contributions on scoping the associated body of knowledge are confounded both by variations in popular use of terminology for established areas, and by the advent of new areas without yet established terminology. Determining the scope of a topic through online bibliographic search filters is a well-established approach in scientific research and has been developed as a human-directed task...
2017: Studies in Health Technology and Informatics
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