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https://www.readbyqxmd.com/read/28214895/development-of-cancer-vaccines-targeting-brachyury-a-transcription-factor-associated-with-tumor-epithelial-mesenchymal-transition
#1
Duane H Hamilton, Justin M David, Charli Dominguez, Claudia Palena
Epithelial-mesenchymal transition (EMT) is recognized as a relevant process during the progression of carcinomas towards metastatic disease. Epithelial cancer cells undergoing an EMT program may acquire mesenchymal features, motility, invasiveness, and resistance to a variety of anticancer therapeutics. Preventing or reverting the EMT process in carcinomas has the potential to minimize tumor dissemination and the emergence of therapeutic resistance. One of the strategies currently under investigation to target tumor cells undergoing EMT is the generation of a sustained immune response directed against an essential molecular driver of the process...
2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28213384/impact-of-a-pharmacy-student-driven-medication-delivery-service-at-hospital-discharge
#2
Jacalyn Rogers, Vinita Pai, Jenna Merandi, Char Catt, Justin Cole, Shannon Yarosz, Allison Wehr, Kayla Durkin, Chet Kaczor
PURPOSE: A pharmacy student-driven discharge service developed for patients to reduce the number of medication errors on after-visit summaries (AVSs) is discussed. METHODS: An audit of AVS documents was conducted before the implementation period (September 3 to October 23, 2013) to identify medication errors. As part of the audit, a pharmacist review of the discharge medication list was completed to determine the number and types of errors that occurred. A student-driven discharge service with AVS review was developed in collaboration with nursing and medical residents...
March 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28210825/recovery-of-nail-dystrophy-potential-new-therapeutic-indication-of-tofacitinib
#3
REVIEW
Jose A Jaller, Juan J Jaller, Antonio M Jaller, Juan J Jaller-Char, Sineida Berbert Ferreira, Rachel Ferreira, Morton Scheinberg
Nail dystrophy is a heterogeneous skin condition and in some subtypes, is associated with autoimmune diseases in particular psoriasis and psoriatic arthritis. In this report, we show that tofacitinib, a novel therapy for rheumatoid arthritis, appears to be beneficial in patients with nail disease refractory to other conventional modes of therapy.
February 16, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28207835/identification-of-plant-cells-in-black-pigments-of-prehistoric-spanish-levantine-rock-art-by-means-of-a-multi-analytical-approach-a-new-method-for-social-identity-materialization-using-cha%C3%A3-ne-op%C3%A3-ratoire
#4
Esther López-Montalvo, Clodoaldo Roldán, Ernestina Badal, Sonia Murcia-Mascarós, Valentín Villaverde
We present a new multi-analytical approach to the characterization of black pigments in Spanish Levantine rock art. This new protocol seeks to identify the raw materials that were used, as well as reconstruct the different technical gestures and decision-making processes involved in the obtaining of these black pigments. For the first of these goals, the pictorial matter of the black figurative motifs documented at the Les Dogues rock art shelter (Ares del Maestre, Castellón, Spain) was characterized through the combination of physicochemical and archeobotanical analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28206760/nano-engineered-eggshell-silver-tailored-co-polyester-polymer-blend-film-with-antimicrobial-properties
#5
Boniface J Tiimob, Gregory Mwinyelle, Woubit Abdela, Temesgen Samuel, Shaik Jeelani, Vijaya K Rangari
In this study, the reinforcement effect of different proportions of eggshell/silver nanomaterial (ES-Ag) on structural and antimicrobial properties of 70/30 poly (butylene-co-adipate terephthalate)/polylactic acid (PBAT/PLA) immiscible blends were investigated. The ES-Ag was synthesized using a single step ball milling process, and characterized with X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). These results confirmed the existence of silver nanoparticles (Ag NPs) in the interstitial spaces of the eggshell particles...
February 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28203208/changes-in-heart-rate-variability-recorded-in-natural-situation-with-t-shirt-integrated-sensors-and-level-of-observed-behavioral-excitation-a-pilot-study-of-patients-with-intellectual-disabilities-and-psychiatric-disorders
#6
Julie Palix, Michel Akselrod, Charly Cungi, Fabienne Giuliani, Jérôme Favrod
BACKGROUND: The present study investigates the possibilities of using heart rate variability (HRV) parameters as physiological markers that precede increase in observed behavioral excitation of intellectually disabled individuals. The ability to recognize or predict such patterns, especially in patients showing unpredictable reactions and language deficiencies, might be a major step forward in clinical research. METHOD: Thirteen volunteers with intellectual disabilities, who had suffered of at least one event of overt aggression in the preceding 3 months, participated to the study...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28201730/improving-social-support-for-older-adults-through-technology-findings-from-the-prism-randomized-controlled-trial
#7
Sara J Czaja, Walter R Boot, Neil Charness, Wendy A Rogers, Joseph Sharit
No abstract text is available yet for this article.
February 15, 2017: Gerontologist
https://www.readbyqxmd.com/read/28199354/nitrate-capture-and-slow-release-in-biochar-amended-compost-and-soil
#8
Nikolas Hagemann, Claudia I Kammann, Hans-Peter Schmidt, Andreas Kappler, Sebastian Behrens
Slow release of nitrate by charred organic matter used as a soil amendment (i.e. biochar) was recently suggested as potential mechanism of nutrient delivery to plants which may explain some agronomic benefits of biochar. So far, isolated soil-aged and composted biochar particles were shown to release considerable amounts of nitrate only in extended (>1 h) extractions ("slow release"). In this study, we quantified nitrate and ammonium release by biochar-amended soil and compost during up to 167 h of repeated extractions in up to six consecutive steps to determine the effect of biochar on the overall mineral nitrogen retention...
2017: PloS One
https://www.readbyqxmd.com/read/28197844/effects-of-non-invasive-vagus-nerve-stimulation-on-attack-frequency-over-time-and-expanded-response-rates-in-patients-with-chronic-cluster-headache-a-post-hoc-analysis-of-the-randomised-controlled-preva-study
#9
Charly Gaul, Delphine Magis, Eric Liebler, Andreas Straube
BACKGROUND: In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve stimulation plus standard of care (nVNS + SoC) than with SoC alone. Given the intensely painful and frequent nature of chronic cluster headache attacks, additional patient-centric outcomes, including the time to and level of therapeutic response, were evaluated in a post hoc analysis of the PREVA study...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28188427/the-prognostic-value-of-right-ventricular-long-axis-strain-in-non-ischaemic-dilated-cardiomyopathies-using-standard-cardiac-magnetic-resonance-imaging
#10
Nisha Arenja, Johannes H Riffel, Manuel Halder, Charly N Djiokou, Thomas Fritz, Florian Andre, Fabian Aus dem Siepen, Thomas Zelniker, Benjamin Meder, Elham Kayvanpour, Grigorios Korosoglou, Hugo A Katus, Sebastian J Buss
OBJECTIVE: To investigate the association of right ventricular long axis strain (RV-LAS), a parameter of longitudinal function, with outcome in patients with non-ischaemic dilated cardiomyopathy (NIDCM). METHODS: In 441 patients with NIDCM, RV-LAS was analysed retrospectively by measuring the length between the epicardial border of the left ventricular apex and the middle of a line connecting the origins of the tricuspidal valve leaflets in end-diastole and end-systole on non-contrast standard cine sequences...
February 10, 2017: European Radiology
https://www.readbyqxmd.com/read/28188351/direct-evidence-from-in-situ-ftir-spectroscopy-that-o-quinonemethide-is-a-key-intermediate-during-the-pyrolysis-of-guaiacol
#11
Hao Cheng, Shubin Wu, Jinbao Huang, Xiaohua Zhang
Although o-quinonemethide (6-methylene-2,4-cyclohexadien-1-one) has been proposed as a key intermediate in char formation during the pyrolysis of guaiacol (2-methoxyphenol), direct evidence of this (e.g., spectroscopic data) has not yet been provided. Using in situ FTIR spectroscopy, the pyrolysis of guaiacol was investigated from 30 °C to 630 °C at 40 °C/min. The IR profiles showed direct evidence of o-quinonemethide production at about 350 °C, which vanished rapidly at around 420 °C in the vapor phase, indicating char formation...
February 10, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28188268/design-and-rationale-of-a-randomized-trial-of-a-care-transition-strategy-in-patients-with-acute-heart-failure-discharged-from-the-emergency-department-guided-hf-get-with-the-guidelines-in-emergency-department-patients-with-heart-failure
#12
Gregory J Fermann, Phillip D Levy, Peter Pang, Javed Butler, S Imran Ayaz, Douglas Char, Patrick Dunn, Cathy A Jenkins, Christy Kampe, Yosef Khan, Vijaya A Kumar, JoAnn Lindenfeld, Dandan Liu, Karen Miller, W Frank Peacock, Samaa Rizk, Chad Robichaux, Russell L Rothman, Jon Schrock, Adam Singer, Sarah A Sterling, Alan B Storrow, Cheryl Walsh, John Wilburn, Sean P Collins
: GUIDED-HF (Get With the Guidelines in Emergency Department Patients With Heart Failure) is a multicenter randomized trial of a patient-centered transitional care intervention in patients with acute heart failure (AHF) who are discharged either directly from the emergency department (ED) or after a brief period of ED-based observation. To optimize care and reduce ED and hospital revisits, there has been significant emphasis on improving transitions at the time of hospital discharge for patients with HF...
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28187191/empirical-and-bayesian-approaches-to-fossil-only-divergence-times-a-study-across-three-reptile-clades
#13
Alan H Turner, Adam C Pritchard, Nicholas J Matzke
Estimating divergence times on phylogenies is critical in paleontological and neontological studies. Chronostratigraphically-constrained fossils are the only direct evidence of absolute timing of species divergence. Strict temporal calibration of fossil-only phylogenies provides minimum divergence estimates, and various methods have been proposed to estimate divergences beyond these minimum values. We explore the utility of simultaneous estimation of tree topology and divergence times using BEAST tip-dating on datasets consisting only of fossils by using relaxed morphological clocks and birth-death tree priors that include serial sampling (BDSS) at a constant rate through time...
2017: PloS One
https://www.readbyqxmd.com/read/28185852/pyrolysis-for-exploitation-of-biomasses-selected-for-soil-phytoremediation-characterization-of-gaseous-and-solid-products
#14
Paola Giudicianni, Stefania Pindozzi, Corinna Maria Grottola, Fernando Stanzione, Salvatore Faugno, Massimo Fagnano, Nunzio Fiorentino, Raffaele Ragucci
Biomasses to be used in the phytoremediation process are generally selected to match agronomic parameters and heavy metals uptake ability. A proper selection can be made greatly effective if knowledge of the properties of the residual char from pyrolysis is available to identify possible valorization routes. In this study a comparative analysis of the yields and characteristics of char obtained from slow pyrolysis of five uncontaminated biomasses (Populus nigra, Salix alba, Fraxinus oxyphylla, Eucalyptus occidentalis and Arundo donax) was carried out under steam atmosphere to better develop char porosity...
February 7, 2017: Waste Management
https://www.readbyqxmd.com/read/28176450/what-has-the-study-of-digital-games-contributed-to-the-science-of-expert-behavior
#15
Neil Charness
I review the historical context for modeling skilled performance in games. Using Newell's (1990) concept of time bands for explaining cognitive behavior, I categorize the current papers in terms of time scales, type of data, and analysis methodologies. I discuss strengths and weaknesses of these approaches for describing skill acquisition and why the study of digital games can address the challenges of replication and generalizability. Cognitive science needs to pay closer attention to population representativeness to enhance generalizability of findings, and to the social band of explanation, in order to explain why so few individuals reach expert levels of performance...
February 7, 2017: Topics in Cognitive Science
https://www.readbyqxmd.com/read/28173961/a-screen-for-modulators-reveals-that-orexin-a-rapidly-stimulates-thyrotropin-releasing-hormone-expression-and-release-in-hypothalamic-cell-culture
#16
Antonieta Cote-Vélez, Anabel Martínez Báez, Leticia Lezama, Rosa María Uribe, Patricia Joseph-Bravo, Jean-Louis Charli
In the paraventricular nucleus of the mammalian hypothalamus, hypophysiotropic thyrotropin releasing hormone (TRH) neurons integrate metabolic information and control the activity of the thyroid axis. Additional populations of TRH neurons reside in various hypothalamic areas, with poorly defined connections and functions, albeit there is evidence that some may be related to energy balance. To establish extracellular modulators of TRH hypothalamic neurons activity, we performed a screen of neurotransmitters effects in hypothalamic cultures...
February 2, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28171835/investigation-of-waste-biomass-co-pyrolysis-with-petroleum-sludge-using-a-response-surface-methodology
#17
Guangji Hu, Jianbing Li, Xinying Zhang, Yubao Li
The treatment of waste biomass (sawdust) through co-pyrolysis with refinery oily sludge was carried out in a fixed-bed reactor. Response surface method was applied to evaluate the main and interaction effects of three experimental factors (sawdust percentage in feedstock, temperature, and heating rate) on pyrolysis oil and char yields. It was found that the oil and char yields increased with sawdust percentage in feedstock. The interaction between heating rate and sawdust percentage as well as between heating rate and temperature was significant on the pyrolysis oil yield...
February 4, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28150149/effects-of-maize-stover-and-its-derived-biochar-on-greenhouse-gases-emissions-and-c-budget-of-brown-earth-in-northeast-china
#18
Xu Yang, Yu Lan, Jun Meng, Wenfu Chen, Yuwei Huang, Xiaoyi Cheng, Tianyi He, Ting Cao, Zunqi Liu, Linlin Jiang, Jiping Gao
Concerns regarding rising population levels and the impacts of atmospheric greenhouse gas (GHG) emissions on world climate have encouraged effective alternative methods to increase agricultural production while mitigating climate change. Soil GHG emissions from maize (Zea mays L.) fields treated with stover and a stover-derived biochar amendment during two consecutive maize growing seasons were studied in a brown earth soil type in Liaoning, China. We considered three treatments: CK (basal application of mineral NPK fertilizer; 120 kg N ha(-1), 60 kg P2O5 ha(-1), and 60 kg K2O ha(-1), respectively), ST (maize stover application; 7...
February 1, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28145891/the-calcification-potential-of-cryogel-scaffolds-incorporated-with-various-forms-of-hydroxyapatite-for-bone-regeneration
#19
Katherine Hixon, Christopher Eberlin, Tracy Lu, Sydney Neal, Natasha Case, Sarah McBride-Gagyi, Scott A Sell
Cryogels are advantageous scaffolds for bone regeneration applications due to their high mechanical stability and macroporous structure. Anatomically, bone is composed of collagen and hydroxyapatite and during remodeling, these structural components are replaced. However, early forms of mineralization include calcium salts which take up to months to be converted to the desired hydroxyapatite form. Thus, it is beneficial to provide a primary source of hydroxyapatite within the scaffold, expediting the process of mineralization during bone regeneration...
February 1, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28137849/holocene-peatland-and-ice-core-data-constraints-on-the-timing-and-magnitude-of-co2-emissions-from-past-land-use
#20
Benjamin David Stocker, Zicheng Yu, Charly Massa, Fortunat Joos
CO2 emissions from preindustrial land-use change (LUC) are subject to large uncertainties. Although atmospheric CO2 records suggest only a small land carbon (C) source since 5,000 y before present (5 kyBP), the concurrent C sink by peat buildup could mask large early LUC emissions. Here, we combine updated continuous peat C reconstructions with the land C balance inferred from double deconvolution analyses of atmospheric CO2 and [Formula: see text]C at different temporal scales to investigate the terrestrial C budget of the Holocene and the last millennium and constrain LUC emissions...
January 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
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