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Torsten Kraya, Marcus Deschauer, Pushpa Raj Joshi, Stephan Zierz, Charly Gaul
BACKGROUND: Mitochondrial diseases are a heterogeneous group of diseases with different phenotypes and genotypes. Headache and, particularly migraine, seems to occur often in patients with MELAS and in patients with CPEO phenotypes. The International Classification of Headache Disorders (ICHD-3 beta) has classified headache as a secondary entity only in MELAS patients. Other headache phenotypes in mitochondrial diseases are not considered in ICHD-3beta. In this study, we analyzed headache phenomenology in a large group of patients with mitochondrial disorders...
November 15, 2017: Headache
Char Ryan
No abstract text is available yet for this article.
November 2017: Journal of Healthcare Management / American College of Healthcare Executives
O Brinkkemper, F Braadbaart, B van Os, A van Hoesel, A van Brussel, R Fernandes
RATIONALE: Isotopic analysis of archaeological charred plant remains offers useful archaeological information. However, adequate sample pre-treatment protocols may be necessary to provide a contamination-free isotopic signal while limiting sample loss and achieving a high throughput. Under these constraints research was undertaken to compare the performance of different pre-treatment protocols. METHODS: Charred archaeological plant material was selected for isotopic analysis (δ(13) C and δ(15) N values) by Isotope Ratio Mass Spectrometry (IRMS) from a variety of plant species, time periods, and soil conditions...
November 14, 2017: Rapid Communications in Mass Spectrometry: RCM
Amal R Khanolkar, Gillian E Hanley, Ilona Koupil, Patricia A Janssen
OBJECTIVE: To determine whether the Institute Of Medicine's (IOM) 2009 guidelines for weight-gain during pregnancy are predictive of maternal and infant outcomes in ethnic minority populations. METHODS: We designed a population-based study using administrative data on 181,948 women who delivered live singleton births in Washington State between 2006-2008. We examined risks of gestational hypertension, preeclampsia/eclampsia, cesarean delivery, and extended hospital stay in White, Black, Native-American, East-Asian, Hispanic, South-Asian and Hawaiian/Pacific islander women according to whether they gained more or less weight during pregnancy than recommended by IOM guidelines...
November 13, 2017: Ethnicity & Health
Feng Xiao, Alemayehu H Bedane, Julia Xiaojun Zhao, Michael D Mann, Joseph J Pignatello
In this study, we systematically investigated the effects of thermal air oxidation on the properties of biomass-derived black carbon (BC) made at carbonization temperatures (HTTs) of 300-700°C. BC produced by including air in the carbonization step was found to have a low surface area and underdeveloped pore structure. Substantial changes of BC were observed after post-pyrolysis thermal air oxidation (PPAO). Well-carbonized BC samples made anoxically at relatively high HTTs (600 and 700°C) showed, after PPAO, significant increases in N2 BET surface area (SA) (up to 700 times), porosity (<60Å) (up to 95 times), and adsorptivity (up to 120 times) of neutral organic species including two triazine herbicides and one natural estrogen...
November 10, 2017: Science of the Total Environment
Jianjun Zhou, Hongrui Ma, Mao Gao, Wenyue Sun, Chao Zhu, Xiangping Chen
The application or disposal of char derived from tannery sludge is directly influenced by the mobility and bioavailability of Cr during pyrolysis process. This study focused on the changes of Cr speciation and organic matter in tannery sludge during low-temperature pyrolysis (100-400 °C) to evaluate the toxicity of char in terms of the leaching possibility of Cr. The results showed that (1) lower char yield and more porous structure were observed after pyrolysis. (2) Higher pyrolysis temperature increased Cr content in the char; however, Cr in this case was converted into the residual fraction which minimized its bioavailability therefore lowers its potential risk to the environment...
November 10, 2017: Environmental Science and Pollution Research International
Justin M David, Charli Dominguez, Kristen K McCampbell, James L Gulley, Jeffrey Schlom, Claudia Palena
Mesenchymalization is a cellular and molecular program in which epithelial cells progressively lose their well-differentiated phenotype and adopt mesenchymal characteristics. Tumor mesenchymalization occurs during the progression of cancer to metastatic disease, and is also associated with resistance to multiple therapeutics, including killing by cytotoxic immune cells. Furthermore, tumor cells can evade immune destruction by upregulating the checkpoint molecule PD-L1, and emerging research has found higher PD-L1 expression in mesenchymalized tumors...
2017: Oncoimmunology
Nuno R Faria, Antonio Charlys da Costa, José Lourenço, Paula Loureiro, Maria Esther Lopes, Roberto Ribeiro, Cecilia Salete Alencar, Moritz U G Kraemer, Christian J Villabona-Arenas, Chieh-Hsi Wu, Julien Thézé, Kamran Khan, Shannon E Brent, Camila Romano, Eric Delwart, Brian Custer, Michael P Busch, Oliver G Pybus, Ester C Sabino
Outbreaks caused by Dengue, Zika and Chikungunya viruses can spread rapidly in immunologically naïve populations. By analysing 92 newly generated viral genome sequences from blood donors and recipients, we assess the dynamics of dengue virus serotype 4 during the 2012 outbreak in Rio de Janeiro. Phylogenetic analysis indicates that the outbreak was caused by genotype II, although two isolates of genotype I were also detected for the first time in Rio de Janeiro. Evolutionary analysis and modelling estimates are congruent, indicating a reproduction number above 1 between January and June, and at least two thirds of infections being unnoticed...
November 9, 2017: Scientific Reports
Kunlin Song, Indroneil Ganguly, Ivan Eastin, Anthony B Dichiara
To reduce fire hazards and expand high-value applications of lignocellulosic materials, thin films comprising graphene nanoplatelets (GnPs) and multi-wall carbon nanotubes (CNTs) pre-adsorbed with alkali lignin were deposited by a Meyer rod process. Lightweight and highly flexible papers with increased gas impermeability were obtained by coating a protective layer of carbon nanomaterials in a randomly oriented and overlapped network structure. Assessment of the thermal and flammability properties of papers containing as low as 4 wt % carbon nanomaterials exhibited self-extinguishing behavior and yielded up to 83...
November 8, 2017: International Journal of Molecular Sciences
Hisaki Makimoto, Andreas Metzner, Roland Richard Tilz, Tina Lin, Christian-H Heeger, Andreas Rillig, Shibu Mathew, Christine Lemeš, Erik Wissner, Karl-Heinz Kuck, Feifan Ouyang
INTRODUCTION: Higher contact force (CF) theoretically increases the risk of blood charring, diminishing lesion formation. We aimed to investigate the relationship between CF, impedance change and char formation during pulmonary vein isolation (PVI). METHODS: CF was assessed during PVI in 65 patients. Radiofrequency ablation (RFA) with power-controlled mode was applied in the point-by-point manner. The RFA were divided into 5 groups: group-A [CF < 10 g], group-B (10 g≤CF < 20 g), group-C (20 g≤CF < 30 g), group-D (30 g≤CF < 40 g), and group-E (CF≥40 g)...
November 8, 2017: Journal of Cardiovascular Electrophysiology
Limin Guo, Zhilin Chen, Shaoyi Lyu, Feng Fu, Siqun Wang
Cellulose nanofibril (CNF) aerogel is highly flammable and its mechanical strength is very soft, which is unfavourable due to safety concerns and impractical when used as the thermal insulation material. In this work, we used N-methylol dimethylphosphonopropionamide (MDPA) and 1,2,3,4-butanetetracarboxylic acid (BTCA) as co-additives and then prepared lightweight flame resistant CNF sponge-like aerogels via an eco-friendly freeze-drying and post cross-linking method. The CNF/BTCA/MDPA aerogel exhibited a better flame retardant performance, outstanding self-extinguishing behaviour and significantly increased char residue (by as much as 268%) compared with the neat CNF aerogel...
January 1, 2018: Carbohydrate Polymers
Xiaowei Dou, Carrie Menkari, Rei Mitsuyama, Tatiana Foroud, Leah Wetherill, Peter Hammond, Michael Suttie, Xiaopan Chen, Shao-Yu Chen, Michael E Charness
Ethanol causes fetal alcohol spectrum disorders (FASD) partly by inhibiting cell adhesion mediated by the L1 neural cell adhesion molecule. Ethanol interacts with an alcohol binding pocket in the L1 extracellular domain (ECD), and dephosphorylation of S1248 in the L1 cytoplasmic domain (CD) renders L1 adhesion insensitive to inhibition by ethanol (L1 insensitive). The mechanism underlying this inside-out signaling is unknown. Here we show that phosphorylation of the human L1-CD at S1152, Y1176, S1181, and S1248 renders L1 sensitive to ethanol by promoting L1 coupling with ankyrin-G and the spectrin-actin cytoskeleton...
November 6, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Charly Abi Ghanem, Cindy Degerny, Rashad Hussain, Philippe Liere, Antoine Pianos, Sophie Tourpin, René Habert, Wendy B Macklin, Michael Schumacher, Abdel M Ghoumari
The oligodendrocyte density is greater and myelin sheaths are thicker in the adult male mouse brain when compared with females. Here, we show that these sex differences emerge during the first 10 postnatal days, precisely at a stage when a late wave of oligodendrocyte progenitor cells arises and starts differentiating. Androgen levels, analyzed by gas chromatography/tandem-mass spectrometry, were higher in males than in females during this period. Treating male pups with flutamide, an androgen receptor (AR) antagonist, or female pups with 5α-dihydrotestosterone (5α-DHT), revealed the importance of postnatal androgens in masculinizing myelin and their persistent effect into adulthood...
November 6, 2017: PLoS Genetics
Yuan Yu, Yunhao Li, Qingwu Zhang, Weishun Ni, Juncheng Jiang
The inerting effect of crystalline II type Ammonium Polyphosphate (APP-II) on explosion characteristics of micron-size Acrylates Copolymer (ACR) powders was experimentally studied. The inerting mechanism was analysed by combining thermogravimetry (TG) and differential scanning calorimetry (DSC) tests. The results indicated that the maximum explosion pressure (Pmax) and explosion index (Kst) was 10.4bar and 416bar m/s, respectively for ACR powders. The minimum explosion concentration (MEC) of ACR powders ranged from 20 to 30g/m(3), and the experimental minimum ignition energy (MIE) of the ACR dust cloud was 10mJ...
October 31, 2017: Journal of Hazardous Materials
Heidi R Thornton, Joanna Miller, Lee Taylor, Charli Sargent, Michele Lastella, Peter M Fowler
Currently, very little is known about the impact of short- or long-haul air travel on the sleep and wellbeing of wheelchair basketball athletes. Eleven national wheelchair basketball athletes wore actigraphy monitors prior, during, and after air travel to the United Kingdom. Upon arrival, participants rated their subjective jet-lag, fatigue, and vigor. Individuals traveled to the United Kingdom from different locations in Australia, the United States, and Europe and were categorised according to travel length [LONG (up to 30...
November 3, 2017: Journal of Sports Sciences
Sermin Onenc, Stefan Retschitzegger, Nikola Evic, Norbert Kienzl, Jale Yanik
This study presents combustion behavior and emission results obtained for different fuels: poultry litter (PL) and its char (PLC), scrap tires (ST) and its char (STC) and blends of char/lignite (PLC/LIG and STC/LIG). The combustion parameters and emissions were investigated via a non-isothermal thermogravimetric method and experiments in a lab-scale reactor. Fuel indexes were used for the prediction of high temperature corrosion risks and slagging potentials of the fuels used. The addition of chars to lignite caused a lowering of the combustion reactivity (anti-synergistic effect)...
October 31, 2017: Waste Management
Charli Dominguez, Kristen K McCampbell, Justin M David, Claudia Palena
The complex signaling networks of the tumor microenvironment that facilitate tumor growth and progression toward metastatic disease are becoming a focus of potential therapeutic options. The chemokine IL-8 is overexpressed in multiple cancer types, including triple-negative breast cancer (TNBC), where it promotes the acquisition of mesenchymal features, stemness, resistance to therapies, and the recruitment of immune-suppressive cells to the tumor site. The present study explores the utility of a clinical-stage monoclonal antibody that neutralizes IL-8 (HuMax-IL8) as a potential therapeutic option for TNBC...
November 2, 2017: JCI Insight
Tara R Shearer, Marc A Kinsley, Anthony P Pease, Jon S Patterson
The purpose of this study was to develop a minimally invasive approach to equine cervical articular facet joints for application of an ND:YAG LASER and to evaluate the effects of the laser fiber on the surrounding tissue. Under general anesthesia, an ND:YAG LASER was used to apply 2000 J of energy to 5 cervical articular facet joints in 3 horses (15 joints total). Horses were euthanized and the cervical facets and spinal cords were examined grossly and histologically. Gross pathology of the articular facets revealed evidence of articular cartilage charring and diffuse roughening of the surface...
November 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
Litong Liang, Juntian Huai, Qian Zhang, Jianwei Liu, Wei Huang, Zhonglin Zhang, Xiaogang Hao, Guoqing Guan
A novel process for improving tar yield through catalytic depolymerization of a typical lignite was put forward. The catalytic depolymerization of the lignite over CoCl2 and ZnCl2 catalyst in different concentrations were investigated by a Gray-King apparatus. The optimal catalyst concentrations of CoCl2 and ZnCl2 catalyst that could obtain the highest tar yield was achieved, by which the tar yield increased about 20.3% and 6.6% compared with that of the raw coal, respectively. Different with the traditional catalytic pyrolysis process for which the tar yield decreased, more tar was produced by the catalytic depolymerization method...
October 31, 2017: Scientific Reports
Zhiqiang Wu, Wangcai Yang, Bolun Yang
In this work, the influence of Nannochloropsis and Chlorella on the thermal behavior and surface morphology of char during the co-pyrolysis process were explored. Thermogravimetric and iso-conversional methods were applied to analyzing the pyrolytic and kinetic characteristics for different mass ratios of microalgae and low-rank coal (0, 3:1, 1:1, 1:3 and 1). Fractal theory was used to quantitatively determine the effect of microalgae on the morphological texture of co-pyrolysis char. The result indicated that both the Nannochloropsis and Chlorella promoted the release of volatile from low-rank coal...
October 9, 2017: Bioresource Technology
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