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https://www.readbyqxmd.com/read/29773148/personalized-treatment-outcomes-in-patients-with-somatoform-disorder-a-concept-mapping-study
#1
Sonja Klemm, Saskia van Broeckhuysen-Kloth, Sanne van Vliet, Lummy Oosterhuis, Rinie Geenen
OBJECTIVE: From a patient-centered perspective, treatment outcome measures in somatoform disorder need to be (1) personalized to the patient, (2) fit core problems that are targeted in therapy, and (3) reflect one's ability to adapt and self-manage anticipated deterioration. The aim of this study was to identify an encompassing set of treatment outcome variables in patients with somatoform disorder. METHODS: In-depth interviews yielded a comprehensive overview of 60 treatment outcomes that were sorted in a card sorting task according to similarity of meaning by 30 patients...
June 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29772057/a-4d-global-respiratory-motion-model-of-the-thorax-based-on-ct-images-a-proof-of-concept
#2
H Fayad, M Gilles, T Pan, D Visvikis
PURPOSE: Respiratory motion reduces the sensitivity and specificity of medical images especially in the thoracic and abdominal areas. It may affect applications such as cancer diagnostic imaging and/or radiation therapy (RT). Solutions to this issue include modelling of the respiratory motion in order to optimize both diagnostic and therapeutic protocols. Personalised motion modeling required patient specific four dimensional (4D) imaging which in the case of 4D computed tomography (4D CT) acquisition is associated with an increased dose...
May 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29766779/technetium-99m-based-radiopharmaceuticals-in-sentinel-lymph-node-biopsy-gynecologic-oncology-perspective
#3
Kamil Zalewski, Malgorzata Benke, Bartlomiej Mirocha, Jakub Radziszewski, Magdalena Chechlinska, Magdalena Kowalewska
Technetium (99mTc)-radiolabeled colloids are popular tracers used to map lymphatic vessels and regional lymph nodes (LNs). The regional LN status is a significant determinant of cancer stage and patient prognosis, and strongly influences treatment. Regional LN dissection has become part of surgical treatment. However, not all patients with LN involvement benefit from extensive lymphadenectomy in terms of prolonged survival. Moreover, overtreatment of patients with localized disease carries unnecessary risk of complications...
May 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29764678/re-engaging-with-places-understanding-bio-geo-graphical-disruption-and-flow-in-adult-brain-injury-survivors
#4
Louise Meijering, Nicky Theunissen, Ant T Lettinga
Acquired Brain Injury (ABI) is one of the most common causes of disability and death in adults worldwide. After a period of rehabilitation, many ABI survivors still face complex mind/body conditions when they try to take up their former life again. Besides lasting visible impairments such as weakness and loss of body balance, there are often less obvious disabilities such as extreme fatigue, hypersensitivity for stimuli, memory, concentration and attention problems or personality changes. The aim of this paper is to understand how ABI survivors and their significant others renegotiate their engagements with everyday places, using the concepts of bio-geo-graphical disruption and flow...
May 5, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29755398/deconvolution-of-human-brain-cell-type-transcriptomes-unraveled-microglia-specific-potential-biomarkers
#5
R Ayana, Shailja Singh, Soumya Pati
Microglial cells form a context-dependent network of brain immunoeffector cells. Despite their indispensable roles, unresolved questions exist around biomarker discovery relevant to their cellular localization, self-renewing potential, and brain developmental dynamics. To resolve the existent gap in the annotation of candidate biomarkers, we conducted a meta-analysis of brain cells using available high-throughput data sets for deciphering microglia-specific expression profiles. We have identified 3,290 significant genes specific to microglia and further selected the top 20 dysregulated genes on the basis of p -value and log2 FC...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29751068/multidimensional-brain-activity-dictated-by-winner-take-all-mechanisms
#6
Arturo Tozzi, James F Peters
A novel demon-based architecture is introduced to elucidate brain functions such as pattern recognition during human perception and mental interpretation of visual scenes. Starting from the topological concepts of invariance and persistence, we introduce a Selfridge pandemonium variant of brain activity that takes into account a novel feature, namely, demons that recognize short straight-line segments, curved lines and scene shapes, such as shape interior, density and texture. Low-level representations of objects can be mapped to higher-level views (our mental interpretations): a series of transformations can be gradually applied to a pattern in a visual scene, without affecting its invariant properties...
May 8, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29749852/ecoevo-maps-an-ecology-and-evolution-assessment-for-introductory-through-advanced-undergraduates
#7
Mindi M Summers, Brian A Couch, Jennifer K Knight, Sara E Brownell, Alison J Crowe, Katharine Semsar, Christian D Wright, Michelle K Smith
A new assessment tool, Ecology and Evolution-Measuring Achievement and Progression in Science or EcoEvo-MAPS, measures student thinking in ecology and evolution during an undergraduate course of study. EcoEvo-MAPS targets foundational concepts in ecology and evolution and uses a novel approach that asks students to evaluate a series of predictions, conclusions, or interpretations as likely or unlikely to be true given a specific scenario. We collected evidence of validity and reliability for EcoEvo-MAPS through an iterative process of faculty review, student interviews, and analyses of assessment data from more than 3000 students at 34 associate's-, bachelor's-, master's-, and doctoral-granting institutions...
June 2018: CBE Life Sciences Education
https://www.readbyqxmd.com/read/29746876/the-spatial-representation-of-number-time-and-serial-order-following-sensory-deprivation-a-systematic-review
#8
REVIEW
Luca Rinaldi, Lotfi B Merabet, Tomaso Vecchi, Zaira Cattaneo
The spatial representation of numerical and temporal information is thought to be rooted in our multisensory experiences. Accordingly, we may expect visual or auditory deprivation to affect the way we represent numerical magnitude and time spatially. Here, we systematically review recent findings on how blind and deaf individuals represent abstract concepts such as magnitude and time (e.g., past/future, serial order of events) in a spatial format. Interestingly, available evidence suggests that sensory deprivation does not prevent the spatial "re-mapping" of abstract information, but differences compared to normally sighted and hearing individuals may emerge depending on the specific dimension considered (i...
May 7, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29746849/characterisation-of-re-entrant-circuit-or-rotational-activity-in-vitro-using-the-hl1-6-myocyte-cell-line
#9
Charles Houston, Konstantinos N Tzortzis, Caroline Roney, Andrea Saglietto, David S Pitcher, Chris Cantwell, Rasheda A Chowdhury, Fu Siong Ng, Nicholas S Peters, Emmanuel Dupont
Fibrillation is the most common arrhythmia observed in clinical practice. Understanding of the mechanisms underlying its initiation and maintenance remains incomplete. Functional re-entries are potential drivers of the arrhythmia. Two main concepts are still debated, the "leading circle" and the "spiral wave or rotor" theories. The homogeneous subclone of the HL1 atrial-derived cardiomyocyte cell line, HL1-6, spontaneously exhibits re-entry on a microscopic scale due to its slow conduction velocity and the presence of triggers, making it possible to examine re-entry at the cellular level...
May 7, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29736594/a-decision-support-tool-facilitating-medicine-design-for-optimal-acceptability-in-the-older-population
#10
Thibault Vallet, Emilie Belissa, Sandra Laribe-Caget, Alain Chevallier, François-Xavier Chedhomme, Patrick Leglise, Matthieu Piccoli, Hugues Michelon, Vanessa Bloch, Sylvie Meaume, Anne-Sophie Grancher, Nathalie Bachalat, Imad Boulaich, Fattima Abdallah, Maite Rabus, Jean-Paul Rwabihama, Annie-Claude Ribemont, Celia Lachuer, Ines Perquy, Laurent Lechowski, Anne Delahaye, Mathieu Depoisson, Yann Orven, Caroline Guinot, Stephane Gibaud, Corinne Michel, Abdel Mahiou, Sid-Ahmed Belbachir, Jean-Hugues Trouvin, Amelie Dufaÿ-Wojcicki, Vincent Boudy, Fabrice Ruiz
PURPOSE: Medicine acceptability, which is of the utmost importance for vulnerable patients' adherence, is driven by both user and product characteristics. Herein, a novel multivariate approach integrating the many aspects of acceptability is used to discriminate positively and negatively accepted medicines in the older population. METHODS: An observational study was carried out in eight hospitals and eight nursing homes to collect a large set of real-life data on medicines uses in older patients (≥65 years)...
May 7, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29736183/universality-of-clone-dynamics-during-tissue-development
#11
Steffen Rulands, Fabienne Lescroart, Samira Chabab, Christopher J Hindley, Nicole Prior, Magdalena K Sznurkowska, Meritxell Huch, Anna Philpott, Cedric Blanpain, Benjamin D Simons
The emergence of complex organs is driven by the coordinated proliferation, migration and differentiation of precursor cells. The fate behaviour of these cells is reflected in the time evolution their progeny, termed clones, which serve as a key experimental observable. In adult tissues, where cell dynamics is constrained by the condition of homeostasis, clonal tracing studies based on transgenic animal models have advanced our understanding of cell fate behaviour and its dysregulation in disease (1, 2). But what can be learned from clonal dynamics in development, where the spatial cohesiveness of clones is impaired by tissue deformations during tissue growth? Drawing on the results of clonal tracing studies, we show that, despite the complexity of organ development, clonal dynamics may converge to a critical state characterized by universal scaling behaviour of clone sizes...
May 2018: Nature Physics
https://www.readbyqxmd.com/read/29732677/creation-and-implementation-of-a-flipped-jigsaw-activity-to-stimulate-interest-in-biochemistry-among-medical-students
#12
Charlene Williams, Susan Perlis, John Gaughan, Sangita Phadtare
Learner-centered pedagogical methods that are based on clinical application of basic science concepts through active learning and problem solving are shown to be effective for improving knowledge retention. As the clinical relevance of biochemistry is not always apparent to health-profession students, effective teaching of medical biochemistry should highlight the implications of biochemical concepts in pathology, minimize memorization, and make the concepts memorable for long-term retention. Here, we report the creation and successful implementation of a flipped jigsaw activity that was developed to stimulate interest in learning biochemistry among medical students...
May 6, 2018: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/29732340/new-pseudo-ct-generation-approach-from-magnetic-resonance-imaging-using-a-local-texture-descriptor
#13
H Chaibi, R Nourine
Background: One of the challenges of PET/MRI combined systems is to derive an attenuation map to correct the PET image. For that, the pseudo-CT image could be used to correct the attenuation. Until now, most existing scientific researches construct this pseudo-CT image using the registration techniques. However, these techniques suffer from the local minima of the non-rigid deformation energy function which leads to unsatisfactory results. Objective: We propose in this paper a new approach for the generation of a pseudo-CT image from an MR image...
March 2018: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/29731726/overcoming-the-subject-object-dichotomy-in-urban-modeling-axial-maps-as-geometric-representations-of-affordances-in-the-built-environment
#14
Lars Marcus
The world is witnessing unprecedented urbanization, bringing extreme challenges to contemporary practices in urban planning and design. This calls for improved urban models that can generate new knowledge and enhance practical skill. Importantly, any urban model embodies a conception of the relation between humans and the physical environment. In urban modeling this is typically conceived of as a relation between human subjects and an environmental object, thereby reproducing a humans-environment dichotomy...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29731681/taxonomic-revision-of-the-graphipterus-serrator-forsk%C3%A3-l-group-coleoptera-carabidae-an-increase-from-five-to-15-valid-species
#15
Ittai Renan, Thorsten Assmann, Amnon Freidberg
The south-west Palaearctic Graphipterus serrator group is revised. The systematic concept of the G. serrator group has undergone many changes during the last two centuries, and several different classifications have been published in recent decades. Here, the numerical taxonomy approach is used with the morphological characterization similarity level of the sympatric taxa in order to delimit allopatrically occurring taxa at the species and subspecies level. A key to the species and distribution maps are provided along with analyses of the conservation status and habitat preferences of the taxa...
2018: ZooKeys
https://www.readbyqxmd.com/read/29728248/determining-anxiety-in-obsessive-compulsive-disorder-through-behavioural-clustering-and-variations-in-repetition-intensity
#16
Conor Cameron, Ibrahim Khalil, David Castle
BACKGROUND AND OBJECTIVES: Over the last decade, the application of computer vision techniques to the analysis of behavioural patterns has seen a considerable increase in research interest. One such interesting and recent application is the visual behavioural analysis of mental disorders. Despite the very recent surge in interest in this area, relatively little has been done thus far to assist individuals living with Obsessive Compulsive Disorder. The work proposed herein represents a proof of concept system designed to demonstrate the efficacy of such an approach, from the computational perspective...
July 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29727023/what-does-popular-media-have-to-tell-us-about-the-future-of-seafood
#17
Tracy Van Holt, Wendy Weisman, Sofia Käll, Beatrice Crona, Rodrigo Vergara
We examined ∼300 newspaper and business-oriented articles published over a 10-year period to assess trends in how seafood "sustainability" is talked about. We mapped key concepts relating to seafood sustainability as the word was used. We asked if the reports provided evidence that perceptions of problems or solutions for sustainability in seafood have changed over time. What were emergent areas of interest, and what concepts relevant to sustainable fisheries and seafood were absent in the reports? The number of reports concerning sustainability that focused on the middle of the supply chain (e...
May 4, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29723806/bioelectrical-coupling-in-multicellular-domains-regulated-by-gap-junctions-a-conceptual-approach
#18
REVIEW
Javier Cervera, Alexis Pietak, Michael Levin, Salvador Mafe
We review the basic concepts involved in bioelectrically-coupled multicellular domains, focusing on the role of membrane potentials (Vmem ). In the first model, single-cell Vmem is modulated by two generic polarizing and depolarizing ion channels, while intercellular coupling is implemented via voltage-gated gap junctions. Biochemical and bioelectrical signals are integrated via a feedback loop between Vmem and the transcription and translation of a protein forming an ion channel. The effective rate constants depend on the single-cell Vmem because these potentials modulate the local concentrations of signaling molecules and ions...
April 21, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29722808/knoto-id-a-tool-to-study-the-entanglement-of-open-protein-chains-using-the-concept-of-knotoids
#19
Julien Dorier, Dimos Goundaroulis, Fabrizio Benedetti, Andrzej Stasiak
Summary: The backbone of most proteins forms an open curve. To study their entanglement, a common strategy consists in searching for the presence of knots in their backbones using topological invariants. However, this approach requires to close the curve into a loop, which alters the geometry of curve. Knoto-ID allows evaluating the entanglement of open curves without the need to close them, using the recent concept of knotoids which is a generalization of the classical knot theory to open curves...
May 2, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29721654/-physician-assistants-in-surgery-a-young-profession-through-graduates-eyes
#20
Marcus Hoffmann, Silke Arnegger, Bettina Mend, Reinhard Hoffmann, Tanja Marschall
BACKGROUND: In Germany, physician assistant (PA) is a comparatively young profession. The concept paper by the German Medical Association (BÄK) and the Federation of Statutory Health Insurance Physicians (KBV) from 2017 defines the new occupational profile in detail. In contrast, there is hardly any information on the day to day working life of a PA in Germany OBJECTIVE: The aim of this study was to map the employment reality of the PA graduates of the study program of the Baden-Wuerttemberg Cooperative State University Karlsruhe...
May 2, 2018: Der Unfallchirurg
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