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Cervical cancer gynecologic

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https://www.readbyqxmd.com/read/28222899/is-the-neutrophil-to-lymphocyte-ratio-prognostic-of-survival-outcomes-in-gynecologic-cancers-a-systematic-review-and-meta-analysis
#1
REVIEW
Josee-Lyne Ethier, Danielle N Desautels, Arnoud J Templeton, Amit Oza, Eitan Amir, Stephanie Lheureux
BACKGROUND: Presence of a high neutrophil-to-lymphocyte ratio (NLR) has been associated with increased mortality in several malignancies. Here, we quantify the effect of NLR on survival in patients with gynecologic cancers, and examine the effect of clinico-pathologic factors on its prognostic value. METHODS: A systematic search of electronic databases was conducted to identify publications exploring the association of pre-treatment blood NLR with overall survival (OS) and event-free survival (EFS) among patients with ovarian, endometrial and cervical cancers...
February 17, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28218162/factors-associated-with-survival-and-lost-to-follow-up-of-cervical-cancer-patients-in-a-tertiary-cancer-centre-in-rural-kerala
#2
T Bindu, Saina Sunil Kumar, K Ratheesan, Satheesan Balasubramanian
Cancer cervix is the second common cause of cancer death in India. It is the most curable form of any human cancer if detected at the precancerous stage. Although several factors determine the survival of the disease, the clinical stage at presentation is the single most important predictor of long-term survival. The present study aimed to describe the performance and follow-up status and 5-year survival experience of the cervical cancer patients registered between 2010 and 2011 by the hospital registry of Malabar Cancer Centre, Kerala, and factors affecting lost to follow-up and survival among them...
January 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28217681/laparoendoscopic-single-site-radical-hysterectomy-for-early-stage-cervical-cancer
#3
Ju Young Park, Yoo Min Kim, Yoo-Young Lee, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae, Chel Hun Choi
Technical developments have made laparoendoscopic single-site (LESS) surgery increasingly more feasible for treating gynecological conditions, including cancer. However, complex surgeries such as radical hysterectomy have rarely been performed with single-port access because of technical difficulties. The majority of the difficulties are due to the inefficient retraction of tissue during dissection. Here, we report a detailed description of LESS radical hysterectomy plus pelvic lymph node dissection that was successfully performed in two patients with stage IB1 cervical cancer...
January 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28211804/comparison-of-elastography-based-on-transvaginal-ultrasound-and-mri-in-assessing-parametrial-invasion-of-cervical-cancer
#4
Xi Ma, Qi Li, Jian-Liang Wang, Jun Shao, Yu-Chun Zhu, Wei Ding, Hou-Sheng Zhang, Hong-Yan Wang, Jun-Kang Shen
OBJECTIVE: The purpose of this study was to evaluate the clinical value of transvaginal elastography (TVES) combined with high-resolution transvaginal ultrasound (TVS) in the detection of parametrial invasion in cervical cancer and to compare the diagnostic performance with magnetic resonance imaging (MRI). MATERIALS AND METHODS: 52 women with histologically confirmed cervical cancer over a 2-year period were staged using International Federation of Gynecology and Obstetrics (FIGO) criteria and underwent MRI and TVES combined with TVS according to a standardized protocol before treatment...
February 17, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28203627/variations-in-gynecologic-oncology-training-in-low-lic-and-middle-income-mic-countries-lmics-common-efforts-and-challenges
#5
REVIEW
Carolyn Johnston, Joseph S Ng, Ranjit Manchanda, Audrey Tieko Tsunoda, Linus Chuang
Gynecologic cancer, cervical cancer in particular, is disproportionately represented in the developing world where mortality is also high. Screening programs, increased availability of chemotherapy, and an awareness of HIV-related cancers have in part accelerated a need for physicians who can treat these cancers, yet the infrastructure for such training is often lacking. In this paper, we address the variations in gynecology oncology training in LMICs as well as the ubiquitous challenges, in an effort to guide future agendas...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28198168/clinical-statistics-of-gynecologic-cancers-in-japan
#6
REVIEW
Wataru Yamagami, Satoru Nagase, Fumiaki Takahashi, Kazuhiko Ino, Toru Hachisuga, Daisuke Aoki, Hidetaka Katabuchi
Cervical, endometrial, and ovarian cancers, have both high morbidity and mortality among the gynecologic malignant tumors in Japan. The present study was conducted using both the population-based cancer registry and the gynecologic cancer registry to elucidate the characteristics of gynecologic malignant tumors in Japan. Based on nationwide estimates from the population-based cancer registry in Japan, the morbidities and mortality of cervical, endometrial, and ovarian cancers were obtained and used for analysis...
March 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28187100/prognostic-significance-of-the-standardized-uptake-value-of-pretherapeutic-18f-labeled-2-fluoro-2-deoxyglucose-positron-emission-tomography-computed-tomography-in-patients-with-locally-advanced-cervical-cancer
#7
Ajit Gubbi, Shimoni Kacheria, Sarfraz Ahmad, Nicole M Stavitzski, James E Kendrick
OBJECTIVES: To determine the prognostic significance of the pretreatment and posttreatment maximum standardized uptake value (SUVmax) of F-labeled 2-fluoro-2-deoxyglucose positron emission tomography (PET)/computed tomography imaging in patients with stage IB2-IVA cervical cancer. METHODS: This was a retrospective review of cervical cancer patients with International Federation of Gynecology and Obstetrics stages IB2-IVA, from March 2008 to April 2014. All patients had pretreatment and posttreatment PET imaging and received primary whole pelvic radiation therapy with concurrent radiosensitizing chemotherapy, followed by intracavitary brachytherapy...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28187094/extraperitoneal-radical-trachelectomy-with-pelvic-lymphadenectomy-a-novel-fertility-preserving-option-for-early-stage-cervical-cancer-patients
#8
Seiji Mabuchi, Tadashi Kimura
OBJECTIVE: Radical trachelectomy combined with pelvic lymphadenectomy has been used to treat early stage cervical cancer patients who wish to preserve their fertility. Although vaginal, abdominal, laparoscopic, and robotic approaches have been used during this procedure, all of these approaches cause peritoneal damage, which could result in periadnexal adhesion. The aim of the present study was to introduce and discuss a novel fertility-preserving option, extraperitoneal radical trachelectomy with pelvic lymphadenectomy...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28187092/incidence-of-venous-thromboembolism-by-type-of-gynecologic-malignancy-and-surgical-modality-in-the-national-surgical-quality-improvement-program
#9
Ashley Graul, Nawar Latif, Xiaochen Zhang, Lorraine T Dean, Mark Morgan, Robert Giuntoli, Robert Burger, Sarah Kim, Emily Ko
BACKGROUND: Women with gynecologic cancer are at higher risk of venous thromboembolism (VTE) due to malignancy, pelvic surgery, increased age, and frequently comorbidities. The rate of VTE among different gynecologic cancers and relative to benign gynecologic surgeries has not been reported in a nationally representative cohort. METHODS: Using the American College of Surgeons National Surgical Quality Improvement Program database, gynecologic surgeries were identified retrospectively from 2006 to 2012...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28187089/clinical-outcome-of-neoadjuvant-radiochemotherapy-in-locally-advanced-cervical-cancer-results-of-an-open-prospective-multicenter-phase-2-study-of-the-north-eastern-german-society-of-gynecological-oncology
#10
Dominique Koensgen, Jalid Sehouli, Antje Belau, Martin Weiss, Matthias B Stope, Vivien Grokopf, Michael Eichbaum, Peter Ledwon, Werner Lichtenegger, Marek Zygmunt, Günter Köhler, Alexander Mustea
OBJECTIVE: The aim of this study was to determine the response rate, toxicity, operability, and surgical complication rate of neoadjuvant concomitant radiochemotherapy (cRCH) (ifosfamide + carboplatin) followed by radical hysterectomy plus external-beam radiotherapy with curative intention in locally advanced primary inoperable stages IIB and IIIB squamous cell cervical cancer. METHODS: Patients with cervical cancer from 8 departments were enrolled. Patients received 3 cycles of ifosfamide 1...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28178620/mir-944-acts-as-a-prognostic-marker-and-promotes-the-tumor-progression-in-endometrial-cancer
#11
Zhonghui He, Hong Xu, Yugang Meng, Yan Kuang
microRNA-944 (miR-944) has been reported to be deregulation and play either tumor suppressive or oncogenic function in human malignancies. Previous studies have reported that miR-944 is overexpressed in gynecological malignancies including cervical cancer and breast cancer. While, the clinical significance of miR-944 and its function in human endometrial carcinoma (EC) keep unknown. The levels of miR-944 were analyzed in 68 EC tissues and 20 normal endometrial tissues. Results showed that miR-944 was significantly overexpressed in EC tissues compared to normal endometrial tissues...
February 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28172838/p693-patients-with-inflammatory-bowel-disease-who-are-on-immunosuppressive-therapy-perform-regular-gynecologic-screening-for-uterine-cervical-cancer
#12
J M Vázquez-Morόn, A Cabello Fernández, H Pallarés-Manrique, M Ramos-Lora
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28168128/three-dimensional-printing-of-a-hemorrhagic-cervical-cancer-model-for-postgraduate-gynecological-training
#13
Michael Bartellas, Stephen Ryan, Gregory Doucet, Deanna Murphy, Jacqueline Turner
INTRODUCTION: A realistic hemorrhagic cervical cancer model was three-dimensionally (3D) printed and used in a postgraduate medical simulation training session. MATERIALS AND METHODS: Computer-assisted design (CAD) software was the platform of choice to create and refine the cervical model. Once the prototype was finalized, another software allowed for the addition of a neoplastic mass, which included openings for bleeding from the neoplasm and cervical os. 3D printing was done using two desktop printers and three different materials...
January 1, 2017: Curēus
https://www.readbyqxmd.com/read/28168125/role-of-gamma-knife%C3%A2-radiosurgery-for-the-treatment-of-brain-metastases-from-gynecological-cancers
#14
Andrew Keller, Rahim Ismail, Peter S Potrebko, Julie Pepe, Meiling Wu, Kunal Saigal, Matthew Biagioli, Ravi Shridhar, Robert Holloway, Melvin Field, Nikhil G Rao
OBJECTIVE: Gamma Knife(®) (GK) (Elekta Instruments, Stockholm, Sweden) radiosurgery is well established for treatment of brain metastases. There are limited data on patients treated with GK from gynecological cancers. The authors sought to determine the effectiveness of the GK in patients with brain metastases from gynecological cancers. METHODS: An IRB-approved database was queried for patients with gynecologic cancers treated with GK between June 1996 and May 2016...
December 31, 2016: Curēus
https://www.readbyqxmd.com/read/28164495/isothermal-method-of-a-recombinase-polymerase-amplification-assay-for-the-detection-of-most-common-high-risk-human-papillomavirus-type-16-and-type-18-dna
#15
Biao Ma, Jiehong Fang, Ye Wang, Haizhen He, Mingyan Dai, Wei Lin, Wei Su, Mingzhou Zhang
BACKGROUND: Cervical cancer is a common gynecologic malignant tumor and has a great impact on women's health. Human papillomavirus (HPV) is implicated in cervical cancer and precancerous lesions and the two are possibly two stages of disease progression. With the technological development of molecular biology and epidemiology, detection and treatment of HPV has become an important means to prevent cervical cancer. METHODS: Here we present a novel, rapid, sensitive and specific isothermal method of recombinase polymerase amplification (RPA), which is established to detect the two most common high-risk human papillomavirus type 16 and type 18 DNA...
January 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28161495/should-the-presence-of-metastatic-para-aortic-lymph-nodes-in-locally-advanced-cervical-cancer-lead-to-more-aggressive-treatment-strategies
#16
Virginia Benito, Sonia Carballo, Patricia Silva, Miriam Esparza, Octavio Arencibia, Mario Federico, Miguel Andújar, Marta Mori, Norberto Medina, Amina Lubrano
OBJECTIVE: To evaluate risk factors in patients with locally advanced cervical cancer (LACC) undergoing pretherapeutic laparoscopic paraaortic lymphadenectomy (LPL), as well as the progression-free and overall survival rates specifically in the subgroup of patients with metastatic paraaortic lymph nodes (PLN). DESIGN: Retrospective study conducted on demographic data, pathological and surgical findings, complications and disease-status, recorded for LACC patients undergoing LPL during the period 2009-2015...
February 1, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28159465/a-comparison-of-sentinel-lymph-node-biopsy-to-lymphadenectomy-for-endometrial-cancer-staging-fires-trial-a-multicentre-prospective-cohort-study
#17
Emma C Rossi, Lynn D Kowalski, Jennifer Scalici, Leigh Cantrell, Kevin Schuler, Rabbie K Hanna, Michael Method, Melissa Ade, Anastasia Ivanova, John F Boggess
BACKGROUND: Sentinel-lymph-node mapping has been advocated as an alternative staging technique for endometrial cancer. The aim of this study was to measure the sensitivity and negative predictive value of sentinel-lymph-node mapping compared with the gold standard of complete lymphadenectomy in detecting metastatic disease for endometrial cancer. METHODS: In the FIRES multicentre, prospective, cohort study patients with clinical stage 1 endometrial cancer of all histologies and grades undergoing robotic staging were eligible for study inclusion...
January 31, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28156638/rolapitant-for-control-of-chemotherapy-induced-nausea-and-vomiting-cinv-in-patients-with-gynecologic-cancer
#18
Lee Steven Schwartzberg, Sujata Arora, Daniel Powers, Karin Jordan, Rudolph M Navari
: 223 Background: Rolapitant, a long-acting neurokinin-1 receptor antagonist, protected against CINV in patients receiving highly or moderately emetogenic chemotherapy (HEC or MEC). METHODS: In 3 double-blind phase 3 studies, patients were randomized to receive oral rolapitant 180 mg or placebo before administration of HEC or MEC. All patients received a 5-hydroxytryptamine type 3 receptor antagonist and dexamethasone. In a post hoc analysis of 3 pooled studies (2 HEC and 1 MEC), we assessed the efficacy and safety of rolapitant in patients with gynecologic (ovarian, uterine, or cervical) cancer...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28139420/transition-from-ldr-to-hdr-brachytherapy-for-cervical-cancer-evaluation-of-tumor-control-survival-and-toxicity
#19
K D Romano, K J Pugh, D M Trifiletti, B Libby, T N Showalter
PURPOSE: In 2012, our institution transitioned from low-dose-rate (LDR) brachytherapy to high dose-rate (HDR) brachytherapy. We report clinical outcomes after brachytherapy for cervical cancer at our institution over a continuous 10-year period. METHODS AND MATERIALS: From 2004 to 2014, 258 women (184 LDR and 74 HDR) were treated with tandem and ovoid brachytherapy in the multidisciplinary management of International Federation of Gynecology and Obstetrics Stages IA-IVB cervical cancer...
January 27, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28133712/hysterectomy-in-the-urologist-s-practice
#20
REVIEW
Steven J Weissbart, Ariana L Smith
Hysterectomy is an important surgical procedure in the care of women with pelvic organ prolapse or lower urinary tract malignancy. Therefore, hysterectomy can be a commonly performed surgical procedure in the urologist's practice. Obtaining a thorough gynecologic history is necessary prior to performing a hysterectomy and prolapse repair. Specifically, reviewing prior cervical cancer screening, risk factors for uterine malignancy, and the role of prophylactic salpingo-oophorectomy are important steps of the reconstructive surgical planning process...
January 2017: Current Urology Reports
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