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Cervical cancer gynecologic

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https://www.readbyqxmd.com/read/29050779/transcriptome-landscape-of-long-intergenic-non-coding-rnas-in-endometrial-cancer
#1
Bei Jun Chen, Frances L Byrne, Konii Takenaka, Susan C Modesitt, Ellen M Olzomer, James D Mills, Rhonda Farrell, Kyle L Hoehn, Michael Janitz
Endometrial cancer is the most common gynecological malignancy in the developed world. It is the fifth most common cancer and accounts for 4.8% of all cancers in women. Long intergenic non-coding RNAs (lincRNAs), a subclass of long non-coding RNAs, are pervasively transcribed throughout the human genome. OBJECTIVE: LincRNA expression patterns in endometrial cancer compared to normal healthy tissue are poorly characterised. In this study, the lincRNA transcriptome of endometrial cancers and adjacent normal endometrium from the same patients was sequenced and compared with transcriptomes of other gynaecologic malignancies including ovarian and cervical cancers...
October 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29045918/cervical-cancer-cells-hela-response-to-photodynamic-therapy-using-a-zinc-phthalocyanine-photosensitizer
#2
Natasha Hodgkinson, Cherie Ann Kruger, Mpho Mokwena, Heidi Abrahamse
Cervical cancer is the most common gynecological malignancy worldwide, and the leading cause of cancer related deaths among females. Conventional treatment for early cervical cancer is radical hysterectomy. In locally advanced cancer the treatment of choice is concurrent chemo radiation. Although such treatment methods show promise, they do have adverse side effects. To minimize these effects, as well as prevent cancer re-occurrence, new treatment methods are being investigated. Photodynamic therapy (PDT) involves the selective uptake of a photosensitizer (PS) by cancer cells, illumination with light of an appropriate wavelength that triggers a photochemical reaction leading to the generation of reactive oxygen and subsequent tumor regression...
October 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29034816/clinical-performance-of-loci%C3%A2-based-tumor-marker-assays-for-tumor-markers-ca-15-3-ca-125-cea-ca-19-9-and-afp-in-gynecological-cancers
#3
Ramona C Dolscheid-Pommerich, Mignon Keyver-Paik, Thomas Hecking, Walther Kuhn, Gunther Hartmann, Birgit Stoffel-Wagner, Stefan Holdenrieder
Evidence is sparse regarding the clinical performance of luminescent oxygen channeling immunoassays-based tumor marker assays in gynecological cancer. Analyzing serum samples of 336 patients with Dimension™Vista1500, we investigated the diagnostic power of carbohydrate antigen 15-3, carbohydrate antigen 125, carcinoembryonic antigen, carbohydrate antigen 19-9, and alpha-fetoprotein in patients suffering from different types of gynecological cancer and precancerous gynecological diseases and compared findings to appropriate control groups...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29034307/uterine-clostridium-perfringens-infection-related-to-gynecologic-malignancy
#4
Kevin M Kremer, Megan E McDonald, Michael J Goodheart
Uterine gas gangrene caused by Clostridium perfringens is a serious, often life-threatening infection that is rarely encountered in the practice of gynecologic oncology. However, the hypoxic nature of gynecologic cancers due to necrosis and/or prior radiation therapy creates a microenvironment optimal for proliferation of anaerobic bacteria such as the Clostridium species. Early recognition and aggressive treatment with IV antibiotics and surgical debridement remain the cornerstones of management in order to decrease morbidity and mortality...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29032160/multimodal-treatment-including-hysterectomy-improves-survival-in-patients-with-locally-advanced-cervical-cancer-a-population-based-propensity-score-matched-analysis
#5
San-Gang Wu, Wen-Wen Zhang, Jia-Yuan Sun, Feng-Yan Li, Zhen-Yu He, Juan Zhou
BACKGROUND: To evaluate the therapeutic value of multimodal treatment including hysterectomy in locally advanced cervical squamous cell carcinoma (SCC). METHODS: We retrospectively reviewed patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IIB-III cervical SCC between 2000 and 2013 using the Surveillance, Epidemiology, and End Results (SEER) program. Propensity score-matching was used to balance baseline characteristics of included patients...
October 12, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29028665/gynecologic-cancer-in-hiv-infected-women-treatment-and-outcomes-in-a-multi-institutional-cohort
#6
Kimberly L Levinson, David J Riedel, Laureen S Ojalvo, Wesley Chan, Ana M Azngarita, Amanda N Fader, Anne F Rositch
OBJECTIVE: To evaluate gynecologic cancer treatments in Human Immunodeficiency Virus (HIV) infected women for adherence to National Comprehensive Cancer Network (NCCN) guidelines and to describe survival by adherence to guidelines. DESIGN: Beyond cervical cancer, there is little data on treatment and outcomes for these women. This is a retrospective cohort study of HIV infected women with gynecologic cancers. METHODS: HIV infected women with gynecologic cancers from 2000-2015 were identified at two urban, comprehensive cancer centers...
October 12, 2017: AIDS
https://www.readbyqxmd.com/read/29027393/down-regulated-serum-microrna-101-is-associated-with-aggressive-progression-and-poor-prognosis-of-cervical-cancer
#7
Wei Jiang, Jia Jia Pan, Ying Hui Deng, Mei Rong Liang, Li Hua Yao
OBJECTIVE: MicroRNAs (miRNAs) play a vital role in pathogenesis and progression of many cancers, including cervical cancer. However, importance of serum level of miR-101 in cervical cancer has rarely been studied. In the present study, clinical significance and prognostic value of serum miR-101 for cervical cancer was investigated. METHODS: Association between miR-101 level in cervical cancer tissues and prognosis of patients was analyzed by using data retrieved from The Cancer Genome Atlas (TCGA) database, which was followed with our clinical study in which miR-101 serum level comparison between cervical cancer patients and healthy controls was conducted by real-time quantitative polymerase chain reaction (PCR)...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28993108/evaluation-of-interfractional-variation-of-organs-and-displacement-of-catheters-during-high-dose-rate-interstitial-brachytherapy-for-gynecologic-malignancies
#8
Soyoung Lee, Ellis Rodney, Bryan Traughber, Tithi Biswas, Valdir Colussi, Tarun Podder
PURPOSE: To investigate the dosimetric effects due to interfractional changes in catheter position and variation in patient's anatomy during the course of interstitial high-dose-rate (HDR) brachytherapy. METHODS AND MATERIALS: A total of 15 patients with either cervical or vaginal cancer underwent interstitial HDR brachytherapy. Interstitial catheters and fiducials were placed under fluoroscopy and intraoperative 3T MRI to confirm the desired catheter placement for adequate target volume coverage...
October 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28988767/could-lymphadenectomy-be-avoided-in-locally-advanced-cervical-cancer-patients-administered-preoperative-chemoradiation-a-large-scale-retrospective-study
#9
Gabriella Ferrandina, Mariagrazia Distefano, Floriana Mascilini, Valerio Gallotta, Vito Chiantera, Francesco Cosentino, Barbara Costantini, Alfredo Ercoli, Luigi Pedone Anchora, Francesco Fanfani, Alessandro Pasquale Margariti, Vincenzo Valentini, Giovanni Scambia
INTRODUCTION: To identify a subset of cervical cancer (CC) patients administered chemoradiation (CT/RT) plus radical surgery (RS), who can be spared lymphadenectomy, and complications. PATIENTS AND METHODS: 430 Stage IB2-IIB patients without LN involvement at imaging were accrued (March 1996-December 2015) at Gynecologic Oncology Unit of the Catholic University of Rome/Campobasso. CT/RT consisted of pelvic irradiation plus cisplatin based chemotherapy. Objective response was evaluated according to RECIST criteria; radical hysterectomy and pelvic ± aortic lymphadenectomy was attempted in patients achieving response or stable disease...
September 23, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28983744/human-papillomavirus-genotype-distribution-among-hpv-positive-women-in-sichuan-province-southwest-china
#10
Guo Tao, Gao Yaling, Gao Zhan, Liao Pu, He Miao
In this hospital-based descriptive study, the genotype distribution of human papillomavirus (HPV) among HPV-infected women were investigated in 4,305 gynecological patients in Sichuan province. Females attending gynecology clinics between March 2014 and March 2015 were subjected to HPV screening after giving informed consent. Cervical scrapings were examined by cytopathology and colposcopy-directed biopsies. HPV genotyping was performed on a Luminex 200 system. Seventeen high-risk (HR) genotypes (HPV-16, -18, -31, -33, -35, -39, -45, -51, -52, -53, -56, -58, -59, -66, -68, -73, and -82) and seven low-risk (LR) genotypes (HPV-6, -11, -42, -43, -61, -81, and -83) were detected...
October 5, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28977944/utility-of-gene-methylation-analysis-cytological-examination-and-hpv-16-18-genotyping-in-triage-of-high-risk-human-papilloma-virus-positive-women
#11
Yan Tian, Na-Yi Yuan Wu, Yu-Ligh Liou, Ching-Tung Yeh, Lanqin Cao, Ya-Nan Kang, Huei-Jen Wang, Yichen Li, Tang-Yuan Chu, Wei Li, Xiang Liu, Yi Zhang, Honghao Zhou, Yu Zhang
In 2015, the American Society for Colposcopy and Cervical Pathology and the Society of Gynecologic Oncology issued interim guidance for the use of a human papillomavirus (HPV) test for primary screening, suggesting triage of women positive for high-risk human papillomavirus (hrHPV) by HPV-16/18 genotyping and cytology for women positive for non-16/18 hrHPV. The design of the present study was based on this interim guidance and analysis of the methylation status of specific candidate genes, which has been proposed as a tool to reduce unnecessary referral following primary HPV screening for cervical cancer...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28973662/treatment-results-of-adjuvant-pelvic-radiotherapy-after-radical-hysterectomy-for-low-risk-stage-ib1-iia-cervical-cancer
#12
Deying Zhao, Hui Qiu, Hui Zhang, Lu Hong, Gong Zhang, Conghua Xie
Objective: The aim of the present retrospective analysis was to determine the effectiveness of pelvic radiotherapy (RT) as postoperative adjuvant therapy for low-risk cervical cancer. Methods: Between June 2003 and April 2011, the clinical data of 225 International Federation of Gynecology and Obstetrics (FIGO) Stage IB1-IIA cervical cancer patients with low-risk factors were retrospectively reviewed, to analyze the relationship between adjuvant pelvic RT after radical hysterectomy and tumor recurrence or the patients' survival...
September 8, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28969759/sentinel-lymph-node-biopsy-procedures
#13
REVIEW
Valeria M Moncayo, Adina L Alazraki, Naomi P Alazraki, John N Aarsvold
Accurate staging of many cancers with no clinical evidence of lymph node involvement is often a critical component of the management of such cancers and is generally and historically accomplished by accurate pathological assessment of multiple nodes. Unfortunately, such assessment usually involves excision of the multiple nodes and can result in significant morbidities. Over the past half century, and particularly over the last quarter century, investigators have defined and refined the "sentinel lymph node(s)" concept and have developed and investigated sentinel lymph node biopsy (SLNB) procedures...
November 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28959365/intensity-modulated-radiotherapy-combined-with-iodine-125-seed-implantation-in-non-central-recurrence-of-cervical-cancer-a-case-report-and-literature-review
#14
Hu Feng, Yuanyuan Hu, Peng Jin, Xiangkuan Meng, Yubing Chen, Hongmei Zhang
Recurrent cervical cancer is a clinically complex disease that is difficult to treat. There are numerous treatment options, but the results achieved by each are poor. External-beam radiation therapy of the pelvic lymph drainage area, in combination with intracavitary afterloading or the interstitial implantation of a radiation source (i.e., brachytherapy), are the current standard radiotherapy regimens used in high-risk clinical targets. However, there are few reports concerning the use of iodine-125 ((125)I) seed implantation brachytherapy in recurrent cervical cancer, and the effects of treatment and adverse reactions have not yet been systematically evaluated...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28951862/metachronous-cancer-of-breast-and-adenocarcinoma-of-cervix-a-rare-case-report
#15
Nalini Sharma, J Lalnunnem Thiek, Das Rituparna, Jaya Mishra, Ahanthem Santa Singh
The occurrence of a second primary cancer in a cancer survivor is well documented. It may be synchronous or metachronous. Incidence of metachronous cancer involving cervix is 0.82% to 1.33%. One such metachronous cancer is that of breast and cervix. We present a case of a woman who received tamoxifen for invasive ductal cancer of breast following a modified radical mastectomy and subsequently developed adenocarcinoma of cervix after six month of tamoxifen therapy. The role of tamoxifen in pathogenesis of cervical cancer and that of human papillomavirus infection in pathogenesis of both cancer of cervix and breast cancer has been well recognized...
August 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/28945212/orthotopic-xenograft-mouse-model-of-cervical-cancer-for-studying-the-role-of-microrna-21-in-promoting-lymph-node-metastasis
#16
Wen-Fei Wei, Ling-Fei Han, Dan Liu, Lan-Fang Wu, Xiao-Jing Chen, Hong-Yan Yi, Xiang-Guang Wu, Mei Zhong, Yan-Hong Yu, Li Liang, Wei Wang
Cervical cancer is the most frequent cause of gynecologic cancer-associated death worldwide. Animal models that demonstrate metastatic patterns consistent with the clinical course of cervical cancer are urgently needed to conduct studies focused on understanding the mechanisms of the disease and identifying optimal treatments. To address this, we established an orthotopic xenograft model of cervical cancer in female NOD-SCID mice using SiHa and ME180 cell lines stably expressing green fluorescent protein to evaluate the role of microRNA-21 (miR-21) in spontaneous lymph node metastasis in vivo...
October 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28941657/effects-of-a-complex-rehabilitation-program-on-edema-status-physical-function-and-quality-of-life-in-lower-limb-lymphedema-after-gynecological-cancer-surgery
#17
Jung Hwa Do, Kyoung Hyo Choi, Jun Su Ahn, Jae Yong Jeon
OBJECTIVE: The purpose of this study was to investigate the effects of a complex rehabilitation (CR) program and complex decongestive therapy (CDT) on edema status, physical function, and quality of life in patients with unilateral lower-limb lymphedema after gynecologic cancer surgery. METHODS: In this randomized pilot study, 40 patients with secondary unilateral lymphedema, after gynecologic surgery for cervical, endometrial, or ovarian cancer, that had been diagnosed based on clinical assessment and 10% volume differences between the legs were randomly assigned to the CDT (n=20) and CDT combined with CR (CRCDT; n=20) groups...
September 20, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28937544/trends-of-gynecological-cancers-in-turkey-toward-europe-or-asia
#18
Murat Gultekin, Irem Kucukyildiz, Mujdegul Zayifoglu Karaca, Selin Dundar, Guledal Boztas, Semra Hatice Turan, Ezgi Hacikamiloglu, Bekir Keskinkilic
OBJECTIVE: The aim of this study was to evaluate nationwide gynecological cancer trends in Turkey. METHODS: National cancer registry data (2009-2013) of Turkish Ministry of Health were evaluated. Ovarian, cervical, endometrial, vulvar, vaginal, and tubal cancers are evaluated with respect to age of diagnosis, incidence rates within years, stage, histological distributions, and mortality rates. Data were collected from active cancer registry centers, which increased from 23% in 2009 to 47...
October 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28937367/associations-between-epidermal-growth-factor-receptor-and-topoisomerase-ii-alpha-gene-copy-number-variations-human-papillomavirus-positivity-and-cytologic-analysis-in-cervical-cell-lesions
#19
Işın Kaya, Oya Nermin Sivrikoz, Özdal Etlik, Abdülkadir Gök
BACKGROUND: Cervical cancer is the second most common gynecologic cancer worldwide. Human papillomavirus (HPV) infection is a leading etiological factor in cervical carcinoma.The aim of this study was to compare HPV positivity, EGFR and TOP2A gene copy number variations and cervical cytologic findings. MATERIALS AND METHODS: The study group comprised 100 female volunteers between 21-64 years old. Cytologic analysis was performed using the liquid-based cytology technique...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28930804/venous-thromboembolism-in-gynecological-malignancy
#20
Abigail Cohen, Chung Sim Lim, Alun Huw Davies
OBJECTIVE: Venous thromboembolism (VTE) is a recognized complication of gynecological malignancy and represents a leading cause of morbidity and mortality in these patients. The review aimed to discuss the incidence, risk factors, and clinical presentation of VTE before examining the literature on the diagnosis, prevention, and management in the context of uterine, cervical, ovarian, and vulval cancers. METHODS/MATERIALS: A literature search was performed using Ovid Medline and Embase with the following words: "gynecological malignancy," "pelvic tumor," "venous thromboembolism," "deep vein thrombosis" and "pulmonary embolism...
September 19, 2017: International Journal of Gynecological Cancer
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