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Cervical cancer gynecologic

John K Chan, Stephanie Chow, Subasish Bhowmik, Amandeep Mann, Daniel S Kapp, Robert L Coleman
Gynecologic cancers comprise of mostly uterine, ovarian, and cervical malignancies and are responsible for 95,000 new cases annually in the United States. Uterine cancer is the most common and the number of new cases and mortality has been increasing. Cervical cancer has decreased due to screening, early detection, and treatment of pre-invasive cancers. However, ovarian cancer remains the most lethal because of advanced stage at diagnosis and drug resistance. The metastatic spread pattern differs amongst these cancers, with uterine and cervical cancer found mostly in the primary organ and ovarian cancer disseminating throughout the peritoneum and upper abdomen at presentation...
June 21, 2018: Clinical & Experimental Metastasis
Chin-Ru Ker, Kun-Ling Lin, Zi-Xi Loo, Yung-Shun Juan, Cheng-Yu Long
Hysterectomy is the empirical treatment for female pelvic organ prolapse (POP) without robust evidence to prove its efficacy. Uphold transvaginal mesh (TVM) system is an innovated device with smaller area, superior anterior/apical support with single incision to treat POP. The prospective cohort study aims to evaluate Uphold TVM's performance with or without concomitant hysterectomy. Inclusion criteria specify patients suffering from stage 2 or more anterior/apical prolapse without previous hysterectomy. Exclusion criteria specify those with contraindications to uterine preservation, such as leiomyomas, adenomyosis, endometrial hyperplasia, abnormal uterine bleeding, postmenopausal bleeding, cervical dysplasia, receiving tamoxifen treatment, family history of gynecology cancer, or colon cancer and incapability to be routinely followed...
June 21, 2018: Scientific Reports
L Chuang, J Berek, T Randall, M McCormack, K Schmeler, R Manchanda, T Rebbeck, C J Jeng, D Pyle, M Quinn, E Trimble, R Naik, C H Lai, K Ochiai, L Denny, N Bhatla
Eighty-five percent of the incidents and deaths from cervical cancer occur in low and middle income countries. In many of these countries, this is the most common cancer in women. The survivals of the women with gynecologic cancers are hampered by the paucity of prevention, screening, treatment facilities and gynecologic oncology providers. Increasing efforts dedicated to improving education and research in these countries have been provided by international organizations. We describe here the existing educational and research programs that are offered by major international organizations, the barriers and opportunities provided by these collaborations and hope to improve the outcomes of cervical cancer through these efforts...
August 2018: Gynecologic Oncology Reports
Uma Singh, Sabuhi Qureshi, Neha Negi, Nisha Singh, Madhumati Goel, Kirti Srivastava
Background & objectives: Cancer cervix is one of the most common forms of genital malignancy among Indian women. Recurrence is seen in a significant number of cases. The conventional cervical smear technique has inherent problems and screening and interpretation errors. This study was undertaken to assess the efficacy of liquid-based cytology (LBC) as a method for cytological follow up and detection of recurrence in treated cases of cancer cervix and to compare it with conventional Pap smear technique to find the best screening method for detection of recurrence in these patients...
March 2018: Indian Journal of Medical Research
Shumei Wang, Yaqi Zhang, Shunping Yuan, Xiaoling Ji
A large body of evidence has indicated that microRNAs (miRNAs/miRs) have essential roles in the development and progression of cervical cancer. Thus, miRNAs with dysregulated expression are potential biomarkers for cervical cancer diagnosis and prognosis. In the present study, expression levels of miR‑485 were detected in cervical cancer tissues and cell lines. The effects of miR‑485 overexpression on the proliferation and invasion of cervical cancer cells were determined with Cell Counting kit‑8 and Transwell invasion assays...
June 18, 2018: Molecular Medicine Reports
Brenna E Swift, Eric Leung, Danielle Vicus, Allan Covens
This study evaluates a novel technique of laparoscopic ovarian transposition performed by Gynecologic Oncologists prior to pelvic radiation for gynecologic cancer. A retrospective review was completed of all patients that underwent laparoscopic ovarian transposition from February 2007 to June 2017 at one tertiary care cancer. The technique involves salpingectomy, followed by retroperitoneal dissection to move the ovaries lateral to the hepatic and splenic flexures of the colon. Normal ovarian function was defined by the absence of vasomotor symptoms, FSH and menstrual history (if menstruating)...
May 2018: Gynecologic Oncology Reports
Sonia Andersson, Karen Belkić, Miriam Mints, Ellinor Östensson
OBJECTIVE: Self-sampling to test for high risk human papilloma virus (HPV) is becoming an increasingly important component of cervical cancer screening. The aim of this observational study is to examine how women treated for high-grade cervical intraepithelial neoplasia (CIN) view HPV self-sampling. METHODS: Invited to participate in the present study were patients who had undergone treatment of high-grade CIN (grade 2 or higher) and were followed-up at 6-months at the Karolinska University Hospital, Stockholm...
2018: PloS One
Hong Zhu, Tao Zheng, Jun Yu, Lixia Zhou, Lei Wang
As one of the commonest gynecological malignancies in the world, cervical cancer brings great threat for public health. Long non-coding RNAs (LncRNAs) have been proved to be closely related to the progression of various cancers, including cervical cancer. As a tumor promoter, lncRNA XIST has been reported in various malignant tumors. In this study, we aim to explore the specific mechanism and biological function of XIST in cervical cancer. At first, the expression levels of XIST were examined in both tissues and cell lines with qRT-PCR...
June 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Biqing Zhu, Quanli Zhang, Yaqin Wu, Jing Luo, Xiufen Zheng, Lin Xu, Emei Lu, Junwei Qu, Binhui Ren
OBJECTIVE: Cervical cancer (CC) is one of the most common gynecologic tumors in women worldwide, with poor prognosis and low survival rate. In this study, we identified SNAP23 as a potential tumor suppressor gene in CC. METHODS: The expression of SNAP23 in tissues and cell lines were measured by qRT-PCR, western blot and IHC. Knockdown of SNAP23 by siRNA and ectopic expression of SNAP23 by overexpression plasmid were performed to observe the biological function of SNAP23 in CC...
June 14, 2018: Gene
Vijayalakshmi Chandrasekhar, Chandrasekhar Krishnamurti
Born in 1883 in Kyme, Greece, George Papanicolaou obtained his medical degree in 1904 from the University of Athens and doctorate in Zoology in 1910 from the University of Munich. He migrated to the USA in 1913 and worked as an assistant at the Department of Anatomy in the Cornell Medical College. There, Papanicolaou examined vaginal smears under his microscope, charted the cyclic ovarian and uterine changes every day and harvested the oocytes at the appropriate time. He published his research on the cytologic patterns in guinea pigs in the American Journal of Anatomy in 1917...
June 2018: Journal of Obstetrics and Gynaecology of India
Min Wang, Wensheng Fan, Mingxia Ye, Chen Tian, Lili Zhao, Jianfei Wang, Wenbo Han, Wen Yang, Chenglei Gu, Mingxia Li, Zhe Zhang, Yongjun Wang, Henghui Zhang, Yuanguang Meng
The goal of this work was to investigate the tumor mutational burden (TMB) in Chinese patients with gynecologic cancer. In total, 117 patients with gynecologic cancers were included in this study. Both tumor DNA and paired blood cell genomic DNA were isolated from formalin-fixed paraffin-embedded (FFPE) specimens and blood samples, and next-generation sequencing was performed to identify somatic mutations. TP53, PTEN, ARID1A, and PIK3CA alterations were significantly different in various types of gynecologic cancers (p = 0...
June 12, 2018: Scientific Reports
Arya Amini, Tyler P Robin, Chad G Rusthoven, Tracey E Schefter, David Akhavan, Yi-Jen Chen, Scott M Glaser, Bradley R Corr, Kimlin T Ashing, Christine M Fisher
OBJECTIVES: The treatment of choice for locally advanced cervical cancer is definitive chemoradiation (CRT). Hysterectomy is not indicated due to higher-rates of cut-through resections leaving gross disease behind, requiring additional therapy with increasing morbidity and no benefit in overall survival (OS). The objectives of this study were to determine factors associated with cut-through hysterectomies and evaluate OS outcomes. MATERIALS AND METHODS: The National Cancer Database (NCDB) was queried for patients 18 years and older with clinical Federation of Gynecology and Obstetrics stage IB2 to IVA...
June 7, 2018: American Journal of Clinical Oncology
Matthew M Harkenrider, Brendan Martin, Karina Nieto, Christina Small, Ibrahim Aref, David Bergman, Anupama Chundury, Mohamed A Elshaikh, David Gaffney, Anuja Jhingran, Larissa Lee, Ima Paydar, Kisuk Ra, Julie Schwarz, Cameron Thorpe, Akila N Viswanathan, William Small
PURPOSE: To investigate the survival endpoints in women with International Federation of Gynecology and Obstetrics (FIGO) stage II endometrial cancer who received adjuvant vaginal brachytherapy (VBT) alone using multi-institutional pooled data. METHODS AND MATERIALS: We performed a multi-institutional analysis of surgically staged patients with FIGO stage II endometrioid-type endometrial cancer treated with VBT alone. Patient, tumor, and treatment characteristics were collected and analyzed...
April 24, 2018: International Journal of Radiation Oncology, Biology, Physics
Eran Ben-Arye, Ofer Dahan, Ilanit Shalom-Sharabi, Noah Samuels
OBJECTIVE: To assess the impact of integrative medicine (IM) on cancer-related fatigue in patients undergoing chemotherapy for early and advanced breast and gynecological (ovarian, endometrial, and cervical) cancer. METHODS: Patients reporting significant levels of fatigue (on the Edmonton Symptom Assessment Scale (ESAS), European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), or Measure Yourself Concerns and Wellbeing questionnaire (MYCAW)) were offered complementary and integrative medicine (CIM) treatments in addition to standard supportive care...
June 7, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Junli Shao, Chaoxi Wang, Linqiu Li, Hairong Liang, Juanxiu Dai, Xiaoxuan Ling, Huanwen Tang
Cervical cancer is a common gynecological malignancy with high incidence and mortality. Drugs commonly used in chemotherapy are often accompanied by strong side-effects. To find an anti-cervical cancer drug with high effects and low toxicity, luteoloside was used to treat the cervical cancer cell line Hela to investigate its effects on cell morphology, proliferation, apoptosis, and related proteins. The study demonstrated that luteoloside could inhibit proliferation remarkably; promote apoptosis and cytochrome C release; decrease the mitochondrial membrane potential and reactive oxygen species level; upregulate the expression of Fas, Bax, p53, phospho-p38, phospho-JNK, and cleaved PARP; downregulate the expression of Bcl-2 and phospho-mTOR; activate caspase-3 and caspase-8; change the nuclear morphology, and fragmentate DNA in Hela cells...
June 5, 2018: International Journal of Molecular Sciences
M Nipčová, J Sláma, T Podlešák, H Neumannová, M Zikán, B Sehnal
OBJECTIVE: To summarize current knowledge of the relationship of genital and oral HPV infection in women. DESIGN: Review article. SETTING: Gynecologic Oncology Center, Department of Gynecology and Obstetrics, Hospital Na Bulovce and 1st Medical School of Charles University, Prague; Gynecologic Oncology Center, Department of Gynecology and Obstetrics, General Faculty Hospital and 1st Medical School of Charles University, Prague; ENT Department, Hospital Na Bulovce, Prague...
2018: Ceská Gynekologie
Rajni Sethi, Yueh Chun Kuo, Babak Edraki, Dimitry Lerner, Daniel Paik, William Bice
PURPOSE: Doppler ultrasound (US) gives real-time information regarding anatomy and blood vessel location to guide needle placement for gynecologic interstitial (IS) brachytherapy (BT). We retrospectively assessed Doppler US images for vessel quantity, size, and distribution in cervical cancer patients undergoing high-dose-rate BT at our institution. METHODS AND MATERIALS: Eleven consecutive patients undergoing IS high-dose-rate BT implants for cervical cancer between 2015 and 2017 were included...
May 31, 2018: Brachytherapy
Yue He, Qun Zhao, Yu-Ning Geng, Shu-Li Yang, Xing-Ming Li, Dominique Finas, Cheng-Hong Yin, Yu-Mei Wu
The purpose of this study is to investigate short-term efficacy as defined by the Response Evaluation Criteria in Solid Tumors (RECIST) and pathological response of neoadjuvant chemotherapy (NACT) comprised of paclitaxel and cisplatin (TP) followed by radical surgery in patients with locally advanced cervical cancer (LACC).This is a prospective study involving 61 women with histologically confirmed LACC referred for NACT following radical surgery at Beijing Obstetrics and Gynecology Hospital between April 2013 and January 2015...
June 2018: Medicine (Baltimore)
Chunyang Feng, Junxue Dong, Weiqin Chang, Manhua Cui, Tianmin Xu
Cervical cancer is one of the most common gynecological tumors in females, which is closely related to high-rate HPV infection. Methylation alteration is a type of epigenetic decoration that regulates the expression of genes without changing the DNA sequence, and it is essential for the progression of cervical cancer in pathogenesis while reflecting the prognosis and therapeutic sensitivity in clinical practice. Hydroxymethylation has been discovered in recent years, thus making 5-hmC, the more stable marker, attract more attention in the field of methylation research...
2018: International Journal of Genomics
Xi Yang, Miao Da, Wenyuan Zhang, Quan Qi, Chun Zhang, Shuwen Han
Cervical cancer is a common malignant cancer among women worldwide. Changes in the vaginal microecological environment lead to multiple gynecological diseases, including cervical cancer. Recent research has shown that Lactobacillus may play an important role in the occurrence and development of cervical cancer. This review explores the role of Lactobacillus in cervical cancer. A total of 29 articles were included after identification and screening. The pertinent literature on Lactobacillus in cervical cancer from two perspectives, including clinical studies and experimental studies, was analyzed...
2018: Cancer Management and Research
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