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Cervical cancer gynecologic

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https://www.readbyqxmd.com/read/28644161/agreement-between-magnetic-resonance-imaging-and-pathologic-findings-in-the-tumor-size-evaluation-before-and-after-neoadjuvant-chemotherapy-treatment-a-prospective-study
#1
Jinlong Cheng, Yan Hou, Junnan Li, Wenjie Wang, Ye Xu, Chunyan Yang, Libing Ma, Harman S Dhillon, Margarita S Openkova, Xin Fan, Zhenzi Li, Kang Li, Ge Lou
OBJECTIVES: To compare the agreement between magnetic resonance imaging (MRI) results and postsurgical pathologic findings for tumor size evaluation in cervical cancer patients before and after neoadjuvant chemotherapy (NACT) treatment. METHODS: The study analyzed the agreement between pretreatment MRI results and postsurgical pathologic findings about the tumor size in 100 cervical cancer patients without NACT and 397 cervical cancer patients with NACT, respectively...
June 23, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28643732/thrombocytosis-in-gynecological-cancers
#2
REVIEW
Deepti Sharma, Garima Singh
Thrombocytosis has been suggested to be a poor prognostic indicator in malignancies. Studies have shown that thrombocytosis is associated with a poor prognosis in various gynecological malignancies such as carcinoma ovary, cervical cancer, and endometrial cancer. The aim of this study is to analyze the impact of thrombocytosis on the prognosis of gynecological cancer. All the relevant data were retrieved by PubMed, MEDLINE, and Web of Science, and then studies were chosen in this analysis of association between thrombocytosis and gynecological malignancy...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28641821/insurance-coverage-among-women-diagnosed-with-a-gynecologic-malignancy-before-and-after-implementation-of-the-affordable-care-act
#3
Haley A Moss, Laura J Havrilesky, Junzo Chino
OBJECTIVE: The Patient Protection and Affordable Care Act (ACA) included provisions to expand insurance coverage by expanding Medicaid eligibility, providing subsidies of private coverage and enforcing an individual mandate. The objective of this study is to examine the impact of the ACA on insurance rates among women diagnosed with a gynecologic malignancy. METHODS: Using Surveillance, Epidemiology, and End Results 18 registries database, women newly diagnosed with cervical, uterine or ovarian cancer between 2008 and 2014 were identified...
June 19, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28641487/microrna-337-inhibits-cell-proliferation-and-invasion-of-cervical-cancer-through-directly-targeting-specificity-protein-1
#4
Wei Dong, Baosheng Li, Juan Wang, Yipeng Song, Zicheng Zhang, Chengrui Fu
Cervical cancer is the fourth most commonly occurring malignancy in females worldwide. Accumulated studies have demonstrated that the aberrant expression of microRNAs plays important roles in tumorigenesis and tumor development and potentially serves as therapeutic targets in various cancers including cervical cancer. Therefore, the identification of specific microRNAs contributed to cervical cancer formation and progression would provide critical clues for the treatments for patients with this disease. In this study, we aimed to detect microRNA-337 expression pattern and investigate the biological roles of microRNA-337 in the regulation of the malignant phenotypes of cervical cancer and its underlying mechanisms...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28640767/surgical-and-pathological-outcomes-of-laparoscopic-versus-abdominal-radical-hysterectomy-with-pelvic-lymphadenectomy-and-or-para-aortic-lymph-node-sampling-for-bulky-early-stage-cervical-cancer
#5
Tao Zhu, Xi Chen, Jianqing Zhu, Yaqing Chen, Aijun Yu, Lu Chen, Huafeng Shou, Meijuan Wu, Ping Zhang
BACKGROUND AND OBJECTIVES: The aim of this study was to compare the feasibility, morbidity, and recurrence rate of total laparoscopic radical hysterectomy (LRH) with those of abdominal radical hysterectomy (ARH) for bulky early-stage cervical cancer. METHODS: We performed a retrospective cohort study of 112 patients with stage IB1 or IIA2 cervical cancer in which the tumor diameter was 3 cm or greater. All patients underwent LRH (n = 30) or ARH (n = 82) with pelvic lymphadenectomy and/or para-aortic lymph node sampling between May 2011 and November 2014...
July 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28639905/high-expression-of-kruppel-like-factor-4-as-a-predictor-of-poor-prognosis-for-cervical-cancer-patient-response-to-radiotherapy
#6
Hai-Xia Liu, Na Li, Li Wei, Fu-Xing Zhou, Rui Ma, Feng Xiao, Wei Zhang, Ying Zhang, Yan-Ping Hui, Hui Song, Bi-Liang Chen
PURPOSE: The aim of this study was to explore the associations of Kruppel-like factor 4 expression with sensitivity to radiation therapy in locally advanced cervical squamous cell carcinoma patients. METHODS: The records of 117 locally advanced cervical squamous cell carcinoma patients were retrospectively reviewed, and Kruppel-like factor 4 expression in cervical carcinoma tissues was examined by immunohistochemical staining. The associations of Kruppel-like factor 4 expression with clinicopathological parameters were analyzed...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28637507/dysregulated-expression-of-long-noncoding-rnas-in-gynecologic-cancers
#7
REVIEW
Elahe Seyed Hosseini, Matthieu Meryet-Figuiere, Hamed Sabzalipoor, Hamed Haddad Kashani, Hossein Nikzad, Zatollah Asemi
Cancers of the female reproductive system include ovarian, uterine, vaginal, cervical and vulvar cancers, which are termed gynecologic cancer. The emergence of long noncoding RNAs (lncRNAs), which are believed to play a crucial role in several different biological processes, has made the regulation of gene expression more complex. Although the function of lncRNAs is still rather elusive, their broad involvement in the initiation and progression of various cancers is clear. They are also involved in the pathogenesis of cancers of the female reproductive system...
June 21, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28633094/impact-of-management-on-mortality-in-patients-with-invasive-cervical-cancer-in-reunion-island
#8
Phuong Lien Tran, Philippe Morice, Emmanuel Chirpaz, Glorianne Lazaro, Malik Boukerrou
OBJECTIVE: In Reunion Island, the standardized mortality rate for cervical cancer is 4.8/100,000 women, twice higher than in Metropolitan France. For locally advanced disease, the standard of care includes a treatment by brachytherapy. Nevertheless, brachytherapy was not available on the Island before 2016. The objective of this study was to assess the impact of the management of patients with invasive cervical cancer on mortality in Reunion. METHODS: We have identified all the women hospitalized in one of the health care centers of the Island diagnosed with invasive cervical cancer between 01/01/2010 and 31/12/2015...
June 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28629611/sentinel-lymph-node-mapping-in-minimally-invasive-surgery-role-of-imaging-with-color-segmented-fluorescence-csf
#9
Maite I Lopez Labrousse, Michael Frumovitz, M Guadalupe Patrono, Pedro T Ramirez
OBJECTIVE: Sentinel lymph node mapping, alone or in combination with pelvic lymphadenectomy, is considered a standard approach in staging of patients with cervical or endometrial cancer [1-3]. The goal of this video is to demonstrate the use of indocyanine green (ICG) and color-segmented fluorescence when performing lymphatic mapping in patients with gynecologic malignancies. METHODS: Injection of ICG is performed in two cervical sites using 1mL (0.5mL superficial and deep, respectively) at the 3 and 9 o'clock position...
June 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28628975/highly-expressed-long-non-coding-rna-nnt-as1-promotes-cell-proliferation-and-invasion-through-wnt-%C3%AE-catenin-signaling-pathway-in-cervical-cancer
#10
Fangfang Hua, Shanshan Liu, Lihong Zhu, Ning Ma, Shan Jiang, Jun Yang
BACKGROUND: Cervical cancer is the most common gynecological malignancies in women worldwide. The previous study showed that lncRNA NNT-AS1 could play an important role in tumor development and metastasis of colorectal cancer. However, little is known about the function of NNT-AS1 in cervical cancer. The aim of this study was to investigate the expression profile of NNT-AS1 in cervical cancer and assess its possible molecular mechanism. METHODS: Relative expression levels of NNT-AS1 in cervical cancer tissues were determined by qRT-PCR...
June 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28627610/silencing-dek-downregulates-cervical-cancer-tumorigenesis-and-metastasis-via-the-dek-p-ser9-gsk-3%C3%AE-p-tyr216-gsk-3%C3%AE-%C3%AE-catenin-axis
#11
Xiaoyang Xu, Lin Zou, Qiuhui Yao, Yanbo Zhang, Li Gan, Liangdan Tang
Cervical cancer is the second most common gynecological malignancy. The mechanisms of the genesis and progression of cervical cancer are complicated and not thoroughly understood. DEK is reported as an oncogene in various cancers, such as acute myeloid leukemia, bladder cancer, breast cancer and hepatocellular cancer. However, its role in cervical cancer has not been well studied. In our study, we confirmed the DEK protein as an oncoprotein in cervical cancer tissues which is correlated to cervical cancer FIGO staging and tumor type...
June 14, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28625396/management-of-menopausal-symptoms-in-women-with-gynecologic-cancers
#12
REVIEW
Marcela G Del Carmen, Laurel W Rice
OBJECTIVE: Women with gynecologic malignancies will be cured or may become long-term survivors. Management of menopausal symptoms is important in addressing their quality of life. We review the benefit and safety of hormone therapy use in these patients. METHODS: MEDLINE was searched for studies on menopause management published in English through December of 2016. RESULTS: Available data suggest that short-term use of hormone therapy in gynecologic cancer patients who do not have an estrogen-dependent malignancy do not adversely impact oncologic outcome and results in improvement of menopausal vasomotor and genitourinary symptoms...
June 15, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28625310/mise-%C3%A3-jour-2016-des-recommandations-pour-la-pratique-clinique-de-nice-saint-paul-de-vence-dans-le-cancer-de-l%C3%A2-ovaire-et-du-col-de-l%C3%A2-ut%C3%A3-rus-%C3%A3-un-stade-avanc%C3%A3
#13
Florence Joly, Denis Querleu, Moise Namer, Eric Pujade-Lauraine
UPDATED 2016 RECOMMENDATIONS FOR THE CLINICAL PRACTICE OF NICE/SAINT-PAUL-DE-VENCE IN OVARIAN CANCER AND ADVANCED CERVICAL CANCER: Since the first edition of the 2012-2013 Clinical Practice Recommendations Nice-Saint-Paul for gynecological cancers, the management of ovarian cancer has become more complex with a better definition of histological subtypes of ovarian cancers, the update of the anatomo-clinical classifications, the evolution of the recommended quality criteria for surgery. In addition, the integration of new medical options, such as PARP inhibitors, requires us to review our management of ovarian cnacer patients (including early systematic oncogenetic research of homologous recombination pathway deficiency)...
May 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28617999/adenosine-an-endogenous-mediator-in-the-pathogenesis-of-gynecological-cancer
#14
REVIEW
Amirhossein Bahreyni, Seyed Sattar Samani, Elnaz Ghorbani, Farzad Rahmani, Reza Khayami, Younes Toroghian, Reihane Behnam-Rassouli, Majid Khazaei, Mikhail Ryzhikov, Mohammad Reza Parizadeh, Malihe Hasanzadeh, Amir Avan, Seyed Mahdi Hassanian
Extracellular concentration of adenosine increases in the hypoxic tumor microenvironment. Adenosine signaling regulates apoptosis, angiogenesis, metastasis and immune suppression in cancer cells. Adenosine-induced cell responses depend upon different subtypes of adenosine receptors activation and type of cancer. Suppression of adenosine signaling via inhibition of adenosine receptors or adenosine generating enzymes including CD39 and CD73 on ovarian or cervical cancer cells is a potentially novel therapeutic approach for gynecological cancer patients...
June 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28617687/preoperatively-assessable-clinical-and-pathological-risk-factors-for-parametrial-involvement-in-surgically-treated-figo-stage-ib-iia-cervical-cancer
#15
Emel Canaz, Eser Sefik Ozyurek, Baki Erdem, Merve Aldikactioglu Talmac, Ipek Yildiz Ozaydin, Ozgur Akbayir, Ceyhun Numanoglu, Volkan Ulker
OBJECTIVE: Determining the risk factors associated with parametrial involvement (PMI) is of paramount importance to decrease the multimodality treatment in early-stage cervical cancer. We investigated the preoperatively assessable clinical and pathological risk factors associated with PMI in surgically treated stage IB1-IIA2 cervical cancer. METHODS: A retrospective cohort study of women underwent Querleu-Morrow type C hysterectomy for cervical cancer stage IB1-IIA2 from 2001 to 2015...
June 14, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28609004/post-fine-needle-aspiration-biopsy-communication-and-the-integrated-and-standardized-cytopathology-report
#16
Martha B Pitman, W Stephen Black-Schaffer
Communication between cytopathologists and patients and their care team is a critical component of accurate and timely patient management. The most important single means of communication for the cytopathologist is through the cytopathology report. Implementation of standardized terminology schemes and structured, templated reporting facilitates the ability of the cytopathologist to provide a comprehensive and integrated report. Cytopathology has been among the pathology subspecialties that have led the way in developing standardized reporting, beginning with the 1954 Papanicolaou classification scheme for cervical-vaginal cytology and continuing through the Bethesda systems for gynecological cytology and several nongynecological cytology systems...
June 2017: Cancer
https://www.readbyqxmd.com/read/28604460/intention-to-treat-analysis-of-radical-trachelectomy-for-early-stage-cervical-cancer-with-special-reference-to-oncologic-failures-single-institutional-experience-in-hungary
#17
Robert Póka, Szabolcs Molnár, Péter Daragó, János Lukács, Rudolf Lampé, Zoárd Krasznai, Zoltán Hernádi
OBJECTIVE: The aim of our study was to evaluate clinical and pathological data in order to draw eligibility criteria for oncologically sufficient radical trachelectomy (RT) in early-stage cervical cancer. Reviewing all cases of attempted RT performed at our unit, we focused attention on prognostic indicators of the need for additional oncologic treatment following RT. The analysis was extended by extensive literature review to include previously published cases of oncologic failures. METHODS: The authors retrospectively analyzed data of patients who underwent RT at the Department of Obstetrics and Gynecology, University of Debrecen...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604458/factors-associated-with-radiation-treatment-compliance-for-women-with-cervical-cancer-in-a-safety-net-health-system
#18
Alfredo Echeverria, Haley Manley, Barrett OʼDonnell, Joshua Asper, Mark Bonnen, Michelle Ludwig
OBJECTIVE: The aim of the study was to determine whether patient characteristics are associated with radiation treatment noncompliance. METHODS/MATERIALS: We retrospectively studied 244 patients with cervical cancer treated with chemoradiation between May 2006 and August 2015 at a safety net health center. Compliance with treatment was defined as missing less than 2 days of scheduled radiation. RESULTS: Treatment records revealed a compliance rate of 50...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604457/up-regulation-of-transcription-factor-3-is-correlated-with-poor-prognosis-in-cervical-carcinoma
#19
Liwen Luo, Hongyu Zhang, Songwen Nian, Chaoqun Lv, Bing Ni, Dan Wang, Zhiqiang Tian
OBJECTIVES: Transcription factor 3 (TCF3, or E2A) is a multifunctional bHLH (basic helix loop helix) transcription factor. The role of TCF3 expression in cancer and the multiple cell signaling pathways that regulate or are influenced by TCF3 are unclear. Therefore, the expression level of TCF3 in patients with cervical squamous cell carcinoma (CSCC) is discussed in this study. METHODS: Total RNA was extracted using real-time quantitative reverse transcription-polymerase chain reaction...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604451/is-tumor-size-really-important-for-prediction-of-lymphatic-dissemination-in-grade-1-endometrial-carcinoma-with-superficial-myometrial-invasion
#20
Murat Oz, Vakkas Korkmaz, Mehmet Mutlu Meydanli, Mustafa Erkan Sari, Zeliha Firat Cuylan, Tayfun Gungor
OBJECTIVES: Selection of patients with endometrioid endometrial cancer (EEC), in whom systematic lymph node dissection (LND) is indicated, is an important part of management to maintain optimal oncological outcomes, while avoiding unnecessary morbidities. According to the current approach, LND is recommended for the patients with International Federation of Gynecology and Obstetrics (FIGO) grade 1 to 2 tumors and a primary tumor diameter (PTD) greater than 2 cm, even with myometrial invasion (MMI) of less than 50%...
June 10, 2017: International Journal of Gynecological Cancer
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