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https://www.readbyqxmd.com/read/28086846/stochastic-agent-based-modeling-of-tuberculosis-in-canadian-indigenous-communities
#1
Ashleigh R Tuite, Victor Gallant, Elaine Randell, Annie-Claude Bourgeois, Amy L Greer
BACKGROUND: In Canada, active tuberculosis (TB) disease rates remain disproportionately higher among the Indigenous population, especially among the Inuit in the north. We used mathematical modeling to evaluate how interventions might enhance existing TB control efforts in a region of Nunavut. METHODS: We developed a stochastic, agent-based model of TB transmission that captured the unique household and community structure. Evaluated interventions included: (i) rapid treatment of active cases; (ii) rapid contact tracing; (iii) expanded screening programs for latent TB infection (LTBI); and (iv) reduced household density...
January 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28079759/the-quantiferon-tb-gold-in-tube-assay-in-neuro-ophthalmology
#2
Leanne M Little, Mohammed Rigi, Ayman Suleiman, Stacy V Smith, Edward A Graviss, Rod Foroozan, Andrew G Lee
BACKGROUND: Although QuantiFERON-TB Gold In-Tube (QFT-GIT) testing is regularly used to detect infection with Mycobacterium tuberculosis, its utility in a patient population with a low risk for tuberculosis (TB) has been questioned. The following is a cohort study analyzing the efficacy of QFT-GIT testing as a method for detection of active TB disease in low-risk individuals in a neuro-ophthalmologic setting. METHODS: Ninety-nine patients from 2 neuro-ophthalmology centers were identified as having undergone QFT-GIT testing between January 2012 and February 2016...
January 11, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28074660/optimizing-the-management-of-children-with-latent-tuberculosis-infection
#3
E Venturini, C Tersigni, E Chiappini, M de Martino, L Galli
The management of latent tuberculosis (LTBI) in children represents an important issue for paediatricians because of the disease burden, the lack of a gold standard for the diagnosis and the high annual risk of progression to active disease. Areas covered: A review of English language articles on LTBI in children, published between the 1(st) of January 2010 and the 1(st) of July 2016, was conducted using multiple keywords and standardized terminology in PubMed database. This review provides an updated overview of the available tests for LTBI diagnosis in children, management strategies and treatment options...
January 11, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28070206/qft-plus-a-plus-in-variability-evaluation-of-new-generation-igra-in-serial-testing-of-students-with-a-migration-background-in-germany
#4
J Knierer, E N Gallegos Morales, A Schablon, A Nienhaus, J F Kersten
BACKGROUND: Currently available Interferon-gamma release assays (IGRAs) show a considerable variability in serial testing for latent tuberculosis infection (LTBI). This study offers first results for the new generation IGRA QuantiFERON-TB Gold Plus (QFT-Plus) introduced in 2015 in comparison with its predecessor QuantiFERON-TB Gold In-Tube (QFT-GIT) from serial testing of students with a migration background at German universities. METHODS: Forty-one students were selected from a previous study...
2017: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/28065210/prevalence-of-tuberculosis-infection-in-healthcare-workers-of-the-public-hospital-network-in-medell%C3%A3-n-colombia-a-bayesian-approach
#5
J Ochoa, A L León, I C Ramírez, C M Lopera, E Bernal, M P Arbeláez
A latent tuberculosis infection (LTBI) prevalence survey was conducted using tuberculin skin test (TST) and Quantiferon test (QFT) in 1218 healthcare workers (HCWs) in Medellín, Colombia. In order to improve the prevalence estimates, a latent class model was built using a Bayesian approach with informative priors on the sensitivity and specificity of the TST. The proportion of concordant results (TST+,QFT+) was 41% and the discordant results contributed 27%. The marginal estimate of the prevalence P(LTBI+) was 62·1% [95% credible interval (CrI) 53·0-68·2]...
January 9, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28061954/multiple-cytokine-responses-in-discriminating-between-active-tuberculosis-and-latent-tuberculosis-infection
#6
Jing Wu, Sen Wang, Chanyi Lu, Lingyun Shao, Yan Gao, Zumo Zhou, Heqing Huang, Ying Zhang, Wenhong Zhang
BACKGROUND: Cytokines play an important role in cell-mediated immune responses against Mycobacterium tuberculosis (Mtb) infection. Cytokine profile specifically associated with active tuberculosis (ATB) patients, subjects with latent tuberculosis infection (LTBI) and non-infected individuals remains to be determined. METHODS: We enrolled a total of 92 subjects including patients with ATB (n = 25), LTBI (n = 36) and healthy controls (HC, n = 31) to investigate the cytokine production by peripheral blood mononuclear cells after Mtb purified protein derivative (PPD) stimulation which was evaluated by a beads-based multiplex assay system...
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/28061953/advances-in-basic-and-translational-tuberculosis-research-proceedings-of-the-first-meeting-of-report-international
#7
REVIEW
Carolina Geadas, Sonia K Stoszek, David Sherman, Bruno B Andrade, Sudha Srinivasan, Carol D Hamilton, Jerrold Ellner
RePORT International is a collaborative research network of investigators from multiple countries and institutions with the goal of establishing a bio-repository of specimens and clinical data for the study of active TB and latent TB infection (LTBI). During the first meeting of RePORT International in Boston, Massachusetts, the results of research pertinent to TB control and eradication were presented, including advances in the research of Mycobacterium tuberculosis (MTB) persistence and drug resistance, TB diagnostics, drug and vaccine development...
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/28060926/comparison-of-tst-and-igra-in-diagnosis-of-latent-tuberculosis-infection-in-a-high-tb-burden-setting
#8
Surendra K Sharma, Richa Vashishtha, L S Chauhan, V Sreenivas, Divya Seth
BACKGROUND: There are currently two tests for diagnosing latent tuberculosis infection (LTBI); TST and IGRA. However, it is still unclear that which one of these tests performs better in high TB-burden settings. METHODS: 1511 household contacts of pulmonary TB patients were enrolled to compare the performance of TST and IGRA for LTBI. At baseline all participant underwent testing for IGRA [QuantiFERON-TB® Gold In-tube (QFT-GIT) assay] and TST [2 tuberculin unit (TU), purified protein derivative (PPD), RT23, Staten Serum Institute (SSI), Copenhagen, Denmark]...
2017: PloS One
https://www.readbyqxmd.com/read/28052967/official-american-thoracic-society-infectious-diseases-society-of-america-centers-for-disease-control-and-prevention-clinical-practice-guidelines-diagnosis-of-tuberculosis-in-adults-and-children
#9
David M Lewinsohn, Michael K Leonard, Philip A LoBue, David L Cohn, Charles L Daley, Ed Desmond, Joseph Keane, Deborah A Lewinsohn, Ann M Loeffler, Gerald H Mazurek, Richard J O'Brien, Madhukar Pai, Luca Richeldi, Max Salfinger, Thomas M Shinnick, Timothy R Sterling, David M Warshauer, Gail L Woods
BACKGROUND: Individuals infected with Mycobacterium tuberculosis (Mtb) may develop symptoms and signs of disease (tuberculosis disease) or may have no clinical evidence of disease (latent tuberculosis infection [LTBI]). Tuberculosis disease is a leading cause of infectious disease morbidity and mortality worldwide, yet many questions related to its diagnosis remain. METHODS: A task force supported by the American Thoracic Society, Centers for Disease Control and Prevention, and Infectious Diseases Society of America searched, selected, and synthesized relevant evidence...
January 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28043609/personalized-information-system-for-the-control-of-tuberculosis-in-resource-limited-settings-a-simplistic-proposal-approach
#10
Benjamin D Thumamo Pokam, Prisca W Guemdjom
Passive case finding remains the mainstay of tuberculosis (TB) control in several resource-limited countries. Although TB prevalence and mortality rates have declined in recent years, an estimated 3 million cases a year still go undetected and/or unreported, and delays in the diagnosis and treatment of TB continue to be widespread. It has been shown that identifying and treating individuals with latent TB infection (LTBI) prevents progression to active TB disease and is one of the key components of TB control strategies...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043588/characterization-of-the-cd4-and-cd8-t-cell-response-in-the-quantiferon-tb-gold-plus-kit
#11
Elisa Petruccioli, Teresa Chiacchio, Ilaria Pepponi, Valentina Vanini, Rocco Urso, Gilda Cuzzi, Lucia Barcellini, Fabrizio Palmieri, Daniela M Cirillo, Giuseppe Ippolito, Delia Goletti
OBJECTIVE/BACKGROUND: QuantiFERON-TB Gold In-Tube (QFT-GIT, Qiagen, Hilden, Germany) is an interferon-γ (IFN-γ) release assay designed to detect latent tuberculosis infection (LTBI). Although QFT-GIT has several advantages (mainly that it is not affected by the Bacille Calmette-Guérin vaccination), it has a poor sensitivity in immune-compromised individuals as it involves an immune response-based detection. Recently, QuantiFERON-TB Gold Plus (QFT-Plus) assay has been proposed as a new generation of QFT-GIT...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043514/modulation-of-interferon-gamma-response-to-quantiferon-tb-plus-detected-by-enzyme-linked-immunosorbent-assay-in-patients-with-active-and-latent-tuberculosis-infection
#12
Elisa Petruccioli, Valentina Vanini, Teresa Chiacchio, Daniela M Cirillo, Fabrizio Palmieri, Giuseppe Ippolito, Delia Goletti
OBJECTIVE/BACKGROUND: Interferon (IFN)-γ-release assays (IGRAs) are designed for the diagnosis of tuberculosis (TB) infection. The new IGRA called QuantiFERON-TB Plus (QFT-Plus) is based on enzyme-linked immunosorbent assay (ELISA) detection of IFN-γ following Myobacterium tuberculosis-antigen stimulation with TB1 and TB2 antigens. TB1 elicits a cell-mediated immune response by CD4 T cells and TB2 elicits a response from both CD4 and CD8 T cells. Here, we characterized variations IFN-γ release detected by ELISA to QFT-IT and QFT-Plus in patients with active TB and latent TB infection (LTBI) at baseline and during or after specific treatment (follow-up)...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043513/modulation-of-cd4-and-cd8-response-to-quantiferon-tb-plus-in-patients-with-active-tuberculosis-and-latent-tuberculosis-infection-followed-over-time-during-treatment
#13
Teresa Chiacchio, Elisa Petruccioli, Ilaria Pepponi, Valentina Vanini, Gina Gualano, Daniela Cirillo, Fabrizio Palmieri, Giuseppe Ippolito, Delia Goletti
OBJECTIVE/BACKGROUND: Interferon (IFN)-γ release assays (IGRA) are designed for diagnosing tuberculosis (TB) infection. The new IGRA, QuantiFERON-TB Plus (QFT-Plus), is based on the enzyme-linked immunosorbent assay detection of IFN-γ after stimulation with Mycobacterium tuberculosis TB1 and TB2 antigens. TB1 elicits a cellular-mediated immune (CMI) response by CD4 T cells, and TB2 contains peptides recognized by both CD4 and CD8 T cells. The aim of the study is to characterize the CMI to QFT-Plus peptides in active TB and latent TB infection (LTBI) at baseline and during or after specific treatment (follow-up)...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28025511/immunological-roles-of-elevated-plasma-levels-of-matricellular-proteins-in-japanese-patients-with-pulmonary-tuberculosis
#14
Beata Shiratori, Jingge Zhao, Masao Okumura, Haorile Chagan-Yasutan, Hideki Yanai, Kazue Mizuno, Takashi Yoshiyama, Tadashi Idei, Yugo Ashino, Chie Nakajima, Yasuhiko Suzuki, Toshio Hattori
Elevated matricellular proteins (MCPs), including osteopontin (OPN) and galectin-9 (Gal-9), were observed in the plasma of patients with Manila-type tuberculosis (TB) previously. Here, we quantified plasma OPN, Gal-9, and soluble CD44 (sCD44) by enzyme-linked immunosorbent assay (ELISA), and another 29 cytokines by Luminex assay in 36 patients with pulmonary TB, six subjects with latent tuberculosis (LTBI), and 19 healthy controls (HCs) from Japan for a better understanding of the roles of MCPs in TB. All TB subjects showed positive results of enzyme-linked immunospot assays (ELISPOTs)...
December 22, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28009090/tuberculosis-screening-using-igra-and-chest-computed-tomography-in-patients-with-inflammatory-bowel-disease-a-retrospective-study
#15
Dongjuan Song, Jinlu Tong, Jiangchen Peng, Chenwen Cai, Xitao Xu, Mingming Zhu, Zhihua Ran, Qing Zheng
BACKGROUND: The prevalence and risk factors of latent tuberculosis infection (LTBI) in Chinese patients with inflammatory bowel disease (IBD) is still poorly understood. Furthermore, the role of interferon gamma release assay (IGRA) test is controversial in serial testing. METHODS: We performed a single-center retrospective study in Shanghai and all the IBD patients who had been investigated for LTBI by T-SPOT.TB between December 2011 and January 2016 were enrolled in the study...
December 23, 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28008662/efficacy-and-safety-of-short-term-treatment-with-isoniazid-and-rifampicin-for-latent-tuberculosis-infection-in-lung-transplant-candidates
#16
Emilio Guirao-Arrabal, Francisco Santos, Javier Redel, José Manuel Vaquero, Julián Torre-Cisneros
BACKGROUND: The current recommendation for the treatment of latent tuberculosis infection (LTBI) in solid organ transplant candidates is isoniazid for 9 months but this treatment has the main problem of frequently reaching the posttransplant period. METHODS: Study of efficacy and safety of a 3 months regimen with isoniazid and rifampicin (3HR) in lung transplant candidates in the Reina Sofía Hospital in Córdoba. RESULTS: 398 lung transplant patients were evaluated...
December 23, 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/28002150/screening-and-treatment-of-latent-tuberculosis-among-patients-receiving-biologic-agents-a-national-and-international-survey-of-rheumatologists
#17
Nhu Quynh Tran, Melinda Garcia-Rosell, Debendra Pattanaik, Syed Hasan Raza, Laura Carbone
OBJECTIVE: We sought to understand the current practice patterns of both US and international members of the American College of Rheumatology (ACR) in this regard. METHODS: A set of questionnaires developed by a focus group of faculties and fellows of the Rheumatology Division of University of Tennessee Health Science Center, Memphis, TN, was sent electronically using an online survey tool to 4433 rheumatologists who are ACR members in the United States and internationally...
January 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27997344/host-immunity-to-mycobacterium-tuberculosis-and-risk-of-tuberculosis-a-longitudinal-study-among-greenlanders
#18
Sascha Wilk Michelsen, Bolette Soborg, Else Marie Agger, Lars Jorge Diaz, Soren Tetens Hoff, Anders Koch, Hans Christian Florian Sorensen, Peter Andersen, Jan Wohlfahrt, Mads Melbye
BACKGROUND: Human immune responses to latent Mycobacterium tuberculosis (Mtb) infection (LTBI) may enable individuals to control Mtb infection and halt progression to tuberculosis (TB), a hypothesis applied in several novel TB vaccines. We aimed to evaluate whether immune responses to selected LTBI antigens were associated with subsequent reduced risk of progression to TB. METHODS: We conducted a population-based cohort study in East Greenland (2012-2014) including individuals aged 5-31years...
November 21, 2016: Vaccine
https://www.readbyqxmd.com/read/27994106/resistance-to-first-line-antituberculosis-drugs-in-washington-state-by-region-of-birth-and-implications-for-latent-tuberculosis-treatment-among-foreign-born-individuals
#19
Nathan W Furukawa, Mahri Z Haider, Sheanne J Allen, Sherry L Carlson, Scott W Lindquist
The United States has a low burden of drug resistance among tuberculosis (TB) cases compared with other world regions. TB is increasingly concentrated among foreign-born individuals who have higher rates of drug resistance than U.S.-born individuals. While universal drug susceptibility testing is the standard for detecting active tuberculosis, there are limited guidelines for latent tuberculosis infection (LTBI) treatment based on risk factors for drug resistance. To quantify the variable risk of drug resistance among foreign-born individuals, all TB cases in Washington State between 1994 and 2014 with drug resistance data for isoniazid, rifampin, pyrazinamide, and ethambutol were divided into eight regions of birth...
December 19, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27986673/diabetes-mellitus-and-latent-tuberculosis-infection-a-systemic-review-and-meta-analysis
#20
Meng-Rui Lee, Ya-Ping Huang, Yu-Ting Kuo, Chen-Hao Luo, Yun-Ju Shih, Chin-Chung Shu, Jann-Yuan Wang, Jen-Chung Ko, Chong-Jen Yu, Hsien-Ho Lin
BACKGROUND: Despite the well-documented association between diabetes and active tuberculosis, evidence on the association between diabetes on latent tuberculosis infection remains limited and inconsistent. METHODS: We included observational studies that: 1) applied either the tuberculin skin test or the interferon gamma release assay for diagnosis of latent tuberculosis infection; and 2) provided adjusted effect estimate for the association between diabetes and latent tuberculosis infection...
December 16, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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