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https://www.readbyqxmd.com/read/28430824/suppressors-of-cytokine-signaling-in-tuberculosis
#1
Shih-Wei Lee, Chi-Wei Liu, Jia-Ying Hu, Li-Mei Chiang, Chih-Pin Chuu, Lawrence Shih-Hsin Wu, Yung-Hsi Kao
Tuberculosis (TB), a global disease mainly infected by Mycobacterium tuberculosis, remains leading public health problem worldwide. Suppressors of cytokine signaling (SOCSs) play important roles in the protection against microbial infection. However, the relationship between members of the SOCS family and tuberculosis infection remains unclear. Using peripheral blood mononuclear cells, we investigated the mRNA expression profiles of SOCS subfamilies among active TB, latent tuberculosis infection (LTBI), and healthy individuals...
2017: PloS One
https://www.readbyqxmd.com/read/28429162/involvement-of-methylated-hbha-expressed-from-mycobacterium-smegmatis-in-an-ifn-%C3%AE-release-assay-to-aid-discrimination-between-latent-infection-and-active-tuberculosis-in-bcg-vaccinated-populations
#2
H-L Wen, C-L Li, G Li, Y-H Lu, H-C Li, T Li, H-M Zhao, K Wu, D B Lowrie, J-X Lv, S-H Lu, X-Y Fan
IFN-γ release assays (IGRAs) based on region of difference 1 (RD1) antigens have improved diagnosis of Mycobacterium tuberculosis (M. tb) infection. However, IGRAs with these antigens cannot discriminate between active tuberculosis (ATB) and latent tuberculosis infection (LTBI). M. tb heparin-binding-hemagglutinin (HBHA) induces relatively high IFN-γ responses in LTBI individuals and low responses in ATB patients, but purification of the native methylated HBHA from cultures of M. tb for immunological tests is complex and time-consuming...
April 20, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28419376/latent-tb-infection-and-pulmonary-tb-disease-among-patients-with-diabetes-mellitus-in-bandung-indonesia
#3
Raspati C Koesoemadinata, Susan M McAllister, Nanny N M Soetedjo, Dwi Febni Ratnaningsih, Rovina Ruslami, Sarah Kerry, Ayesha J Verrall, Lika Apriani, Reinout van Crevel, Bachti Alisjahbana, Philip C Hill
Background: Screening and treatment of latent TB infection (LTBI) and TB disease could reduce diabetes mellitus (DM)-associated TB. We aimed to describe the prevalence of LTBI and pulmonary TB among patients with DM in a TB-endemic setting. Methods: Patients with DM attending a hospital and community centres in Bandung, Indonesia, underwent LTBI screening using interferon gamma release assay (IGRA). TB was investigated by sputum smear, culture and x-ray. TB contacts from a parallel study were age- and sex-matched to patients with DM to compare LTBI and TB disease prevalence...
April 13, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28415587/detection-of-a-combination-of-serum-igg-and-iga-antibodies-against-selected-mycobacterial-targets-provides-promising-diagnostic-signatures-for-active-tb
#4
Dolapo O Awoniyi, Ralf Baumann, Novel N Chegou, Belinda Kriel, Ruschca Jacobs, Martin Kidd, Andre G Loxton, Susanne Kaempfer, Mahavir Singh, Gerhard Walzl
Immunoglobulin G (IgG) based tests for the diagnosis of active tuberculosis (TB) disease often show a lack of specificity in TB endemic regions, which is mainly due to a high background prevalence of LTBI. Here, we investigated the combined performance of the responses of different Ig classes to selected mycobacterial antigens in primary healthcare clinic attendees with signs and symptoms suggestive of TB. The sensitivity and specificity of IgA, IgG and/or IgM to LAM and 7 mycobacterial protein antigens (ESAT-6, Tpx, PstS1, AlaDH, MPT64, 16kDa and 19kDa) and 2 antigen combinations (TUB, TB-LTBI) in the plasma of 63 individuals who underwent diagnostic work-up for TB after presenting with symptoms and signs compatible with possible active TB were evaluated...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28409555/treatment-of-latent-tuberculosis-infection
#5
Connie A Haley
There are approximately 56 million people who harbor Mycobacterium tuberculosis that may progress to active tuberculosis (TB) at some point in their lives. Modeling studies suggest that if only 8% of these individuals with latent TB infection (LTBI) were treated annually, overall global incidence would be 14-fold lower by 2050 compared to incidence in 2013, even in the absence of additional TB control measures. This highlights the importance of identifying and treating latently infected individuals, and that this intervention must be scaled up to achieve the goals of the Global End TB Strategy...
April 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28407146/high-rates-of-latent-tb-infection-in-contacts-and-the-wider-community-in-south-india
#6
Padmanesan Narasimhan, Chandini Raina MacIntyre, Dilip Mathai, James Wood
Background: We aimed to compare TB transmission rates between case and community households in Vellore, South India. Methods: 359 household contacts (HHC) and 363 community contacts (CC) were assessed with tuberculin skin test (TST) and QuantiFERON TB Gold In-Tube test (QFT) between August 2010 and September 2011. Concordance test and multivariate risk factor assessment were conducted using logistic regression adjusted for clustering. Results: Latent TB infection (LTBI) positivity was similar between the two groups using both tests, with only moderate concordance observed between QFT and TST...
April 12, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28404472/the-prevalence-of-latent-tuberculosis-infection-in-rural-jiangsu-china
#7
Y Liu, S Huang, H Jiang, J Xiong, Y Wang, M Ou, J Cai, C Yang, Z Wang, S Ge, N Xia
OBJECTIVES: Diagnosis and interventional treatment of latent tuberculosis (TB) infection (LTBI) are important components in tuberculosis control. But systematic studies regarding the epidemic of LTBI are still rare in China. The objective of this study was to assess the prevalence and risk factors associated with LTBI based on the results of a domestic TB-specific gamma interferon (IFN-γ) release assay (TB-IGRA) in rural Jiangsu, China. STUDY DESIGN: Cross-sectional study of subjects registered in eight villages in Jiangsu, China...
February 4, 2017: Public Health
https://www.readbyqxmd.com/read/28399977/acute-kidney-injury-during-treatment-for-latent-tuberculous-infection-with-rifampin
#8
J M Wortham, M Goggin, C Mora, L Vandehey, L Manangan, K M Powell
Treatment for latent tuberculous infection (LTBI) is a key strategy for the elimination of tuberculosis. Rare adverse reactions associated with LTBI treatment have been reported. We report the only case of acute kidney injury reported to Centers for Disease Control and Prevention surveillance for LTBI treatment-related adverse events. The patient experienced rapid intravascular hemolysis, resulting in heme pigment nephropathy; he was hospitalized and received three hemodialysis treatments, but recovered without sequelae...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28399802/efficacy-and-completion-rates-of-rifapentine-and-isoniazid-3hp-compared-to-other-treatment-regimens-for-latent-tuberculosis-infection-a-systematic-review-with-network-meta-analyses
#9
Christopher Pease, Brian Hutton, Fatemeh Yazdi, Dianna Wolfe, Candyce Hamel, Pauline Quach, Becky Skidmore, David Moher, Gonzalo G Alvarez
BACKGROUND: We conducted a systematic review and network meta-analysis (NMA) to examine the efficacy and completion rates of treatments for latent tuberculosis infection (LTBI). While a previous review found newer, short-duration regimens to be effective, several included studies did not confirm LTBI, and analyses did not account for variable follow-up or assess completion. METHODS: We searched MEDLINE, Embase, CENTRAL, PubMed, and additional sources to identify RCTs in patients with confirmed LTBI that involved a regimen of interest and reported on efficacy or completion...
April 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28395400/a-dissent-from-including-high-school-students-as-a-target-subject-of-control-progarm-against-latent-tubereculosis-infection-in-korea
#10
Jong-Myon Bae
Centers for Diseases Control and Prevention in Korea (KCDC) has announced the control program against latent tuberculosis infection (LTBI) for making 'TB Safe country' in this year. As the program included high school students as one of target groups, some opposite opinions were suggested by school teachers of health preservation as well as parents. The WHO guideline for LTBI published in 2015 did not recommend to include asymptomatic students on LTBI control program, Thus, KCDC should consider to exclude them based on the WHO guideline in order to persuade the opposites before implementing the program in earnest...
March 31, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28392318/the-performance-of-the-tbag-pha-ratio-in-the-diagnosis-of-active-tb-disease-in-immunocompromised-patients
#11
Munyemana Jean Bosco, Hongyan Hou, Lie Mao, Xiaohui Wu, Kreeti Devi Ramroop, Yanfang Lu, Liyan Mao, Yu Zhou, Ziyong Sun, Feng Wang
OBJECTIVES: The results of the T-SPOT.TB (T-SPOT) assay are reduced in immunocompromised patients with active tuberculosis (ATB), and it is difficult for using T-SPOT results to distinguish ATB from latent tuberculosis infection (LTBI) in this condition. The aim of this study was to determine the performance of the TBAg/PHA ratio in T-SPOT assay in the diagnosis of ATB in immunocompromised patients. METHODS: One hundred and forty three immunocompromised ATB patients and 124 LTBI individuals were diagnosed according to conventional tests and T-SPOT assay...
April 6, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28392316/prevalence-of-latent-mycobacterium-tuberculosis-infection-ltbi-in-saudi-arabia-population-based-survey
#12
Hanan H Balkhy, Kamel El Beltagy, Aiman El-Saed, Badr Aljasir, Abdulhakeem Althaqafi, Adel F Alothman, Mohammad Alshalaan, Hamdan Al-Jahdali
BACKGROUND: The annual risk of tuberculosis infection (ARTI) data in Saudi Arabia has never been updated since 1993. OBJECTIVES: To estimate the prevalence of latent TB infection (LTBI) and ARTI in a population-based sample in Saudi Arabia using Tuberculin skin test (TST) and QuantiFERON TB Gold in tube (QFT-GIT) test. METHODS: A population-based cross sectional study was conducted between July 2010 and March 2013. Participants were randomly selected from the population served by the primary healthcare centers of the Ministry of National Guard Health Affairs in Riyadh, Jeddah, Alhassa and Dammam, Saudi Arabia...
April 6, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28369346/epidemiology-of-latent-tuberculosis-infection-among-patients-with-and-without-diabetes-mellitus
#13
Yogarabindranath Swarna Nantha, Anurupa Puri, Siti Zubaidah Mohamad Ali, Poopathy Suppiah, Siti Aishah Che Ali, Bhavani Ramasamy, Intan Masni Ibrahim
Background.: Individuals with type 2 diabetes mellitus (DM) are at a greater risk of tuberculosis (TB) reactivation. There is a paucity of information about the risk factors associated with latent tuberculosis infection (LTBI) in patients with diabetes. Objective.: We conducted an observational study to compare the prevalence and risk factors associated with LTBI factors in Malaysian adults with and without DM. Methods.: Four hundred and four patients with DM and 359 patients with non-DM at a regional primary care clinic were recruited as participants in this case-control study...
March 23, 2017: Family Practice
https://www.readbyqxmd.com/read/28359877/a-new-method-of-screening-for-latent-tuberculosis-infection-results-from-army-recruits-in-beijing-in-2014
#14
Xuejuan Bai, Yan Liang, Yourong Yang, Junxian Zhang, Xueqiong Wu
Latent tuberculosis infection (LTBI) lacks diagnostic gold method. Effective method is important to the control of tuberculosis. IFN-γ responses in 600 military recruits were tested by ELISA using whole blood incubation with latent protein Rv2029c, Rv2659c and recombinant protein CFP10-ESAT6 (rCE) respectively. They also received tuberculin skin test. Their BCG vaccination status was recorded. When 30.7% (184/600) of recruits gave higher IFN-γ responses (≥470pg/mL) to rCE as LTBI, the rests as healthy control, the AUC of rRv2029c was 0...
March 27, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28333913/tuberculosis-among-foreign-born-persons-diagnosed-%C3%A2-10-years-after-arrival-in-the-united-states-2010-2015
#15
Clarisse A Tsang, Adam J Langer, Thomas R Navin, Lori R Armstrong
The majority of tuberculosis (TB) cases in the United States are attributable to reactivation of latent TB infection (LTBI) (1). LTBI refers to the condition when a person is infected with Mycobacterium tuberculosis without signs and symptoms, or radiographic or bacteriologic evidence of TB disease. CDC and the U.S. Preventive Services Task Force (USPSTF) recommend screening populations at increased risk for LTBI, including persons who have lived in congregate settings at high risk and persons who were born in, or are former residents of countries with TB incidence ≥20 cases per 100,000 population (2-4)...
March 24, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28333908/tuberculosis-united-states-2016
#16
Kristine M Schmit, Zimy Wansaula, Robert Pratt, Sandy F Price, Adam J Langer
In 2016, a total of 9,287 new tuberculosis (TB) cases were reported in the United States; this provisional* count represents the lowest number of U.S. TB cases on record and a 2.7% decrease from 2015 (1). The 2016 TB incidence of 2.9 cases per 100,000 persons represents a slight decrease compared with 2015 (-3.4%) (Figure). However, epidemiologic modeling demonstrates that if similar slow rates of decline continue, the goal of U.S. TB elimination will not be reached during this century (2). Although current programs to identify and treat active TB disease must be maintained and strengthened, increased measures to identify and treat latent TB infection (LTBI) among populations at high risk are also needed to accelerate progress toward TB elimination...
March 24, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28333182/early-tuberculin-skin-test-for-the-diagnosis-of-latent-tuberculosis-infection-in-patients-with-inflammatory-bowel-disease
#17
Carlos Taxonera, Ángel Ponferrada, Fernando Bermejo, Sabino Riestra, Cristina Saro, María Dolores Martín-Arranz, José Luis Cabriada, Manuel Barreiro-de Acosta, María Luisa de Castro, Pilar López-Serrano, Jesús Barrio, Cristina Suarez, Eva Iglesias, Federico Argüelles-Arias, Isabel Ferrer, Ignacio Marín-Jiménez, Alejandro Hernández-Camba, Guillermo Bastida, Manuel Van Domselaar, Pilar Martínez-Montiel, David Olivares, Cristina Alba, Javier P Gisbert
Background and Aim: Sensitivity of tuberculin skin test [TST] during screening for latent tuberculosis infection [LTBI] is affected by steroid and/or immunosuppressant therapy. The aim of this study was to compare performance of the two-step TST in inflammatory bowel disease patients immediately before anti-tumour necrosis factor [TNF] therapy as part of routine screening for LTBI vs control patients when the TST was carried out at an early stage. Methods: In this multicentre prospective controlled study, we evaluated the performance of two-step TST with 5-mm threshold...
February 17, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28329197/systematic-review-meta-analysis-and-cost-effectiveness-of-treatment-of-latent-tuberculosis-infection-to-reduce-progression-to-multidrug-resistant-tuberculosis
#18
Suzanne M Marks, Sundari R Mase, Sapna Bamrah Morris
Background: Evidence-based recommendations for treating persons having presumed latent tuberculosis infection (LTBI) after contact to infectious multidrug-resistant tuberculosis (MDR TB) are lacking because published data consist of small observational studies. TB incidence in persons treated for latent multidrug-resistant-TB infection (MDR LTBI) is unknown. Methods: We conducted a systematic review of studies published (1/1/1994-12/31/2014) to analyze TB incidence, treatment completion and discontinuation, and cost effectiveness...
March 14, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28329119/stratification-of-latent-tuberculosis-infection-by-cellular-immune-profiling
#19
Alice Halliday, Hilary Whitworth, Sherine Hermagild Kottoor, Umar Niazi, Sarah Menzies, Heinke Kunst, Samuel Bremang, Amarjit Badhan, Peter Beverley, Onn Min Kon, Ajit Lalvani
Background: Recently-acquired and remotely-acquired latent tuberculosis (TB) infection (LTBI) are clinically indistinguishable, yet recent acquisition of infection is the greatest risk factor for progression to active TB (ATB) in immunocompetent individuals. We aimed to evaluate the ability of cellular immune signatures which differ between ATB and LTBI, to distinguish recently from remotely acquired LTBI. Methods: Fifty-nine individuals were recruited: ATB (n=20); recent LTBI (n=19); remote LTBI (n=20)...
February 28, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28327495/risk-factors-for-latent-tuberculosis-infection-ltbi-in-health-profession-s-students-of-the-university-of-parma
#20
Silvia Bonini, Maria Grazia Riccelli, Matteo Goldoni, Luisella Selis, Massimo Corradi
BACKGROUND AND AIM OF THE WORK: Nowadays Tuberculosis (TB) is one of the major Public Health problems for several professional categories. According to Italian law, University students are compared to workers: the main risk for them is represented by biological risk, in particular by blood-transmitted or by air-transmitted agents. As for TB, many scientific studies demonstrated that prevalence of latent tuberculosis infection (LTBI) in Medicine and Surgery students was lower than those in health workers and in general population...
March 14, 2017: Acta Bio-medica: Atenei Parmensis
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