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https://www.readbyqxmd.com/read/29677310/who-issues-new-guidelines-for-ltbi
#1
M J Friedrich
No abstract text is available yet for this article.
April 17, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29663962/tuberculous-lymphadenitis-is-associated-with-altered-levels-of-circulating-angiogenic-factors
#2
G R Kathamuthu, K Moideen, D Baskaran, G Sekar, S Rathinam, V J Bharathi, G R Ganeshan, S Babu
BACKGROUND: Angiogenic factors are important in granuloma formation and serve as biomarkers in pulmonary tuberculosis (PTB). The relationship between these markers and tuberculous lymphadenitis (TBL) is not known. OBJECTIVE AND DESIGN: To examine the association of vascular endothelial growth factor (VEGF) and angiopoietin (Ang) family molecules in TBL, we measured systemic levels of VEGF-A, C, D, R1 (VEGF-receptor 1), R2, R3, Ang-1, Ang-2 and TIE2 (tyrosine kinase with immunoglobulin-like and epidermal growth factor-like domains 2) levels in TBL, latent tuberculous infection (LTBI) and lymph node culture supernatants (VEGF-A, C and Ang-2) of the same TBL patients...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29663956/paradox-of-serial-interferon-gamma-release-assays-variability-width-more-important-than-specificity-size
#3
J E Stout, R Belknap, Y-J Wu, C S Ho
SETTING: Serial screening for latent tuberculous infection (LTBI) is commonly performed in certain populations, such as health care workers. The high apparent conversion rate in some studies of interferon-gamma release assays is puzzling given the claimed high specificity of these tests. OBJECTIVE: To understand how test-retest variability, specificity, and underlying LTBI prevalence affect observed outcomes of repeated testing for LTBI. DESIGN: Mathematical model assuming constant test sensitivity and specificity over time and no new infections...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29663954/characteristics-of-a-large-latent-tuberculous-infection-screening-programme-using-quantiferon-%C3%A2-tb-gold-in-korea
#4
H-J Hwang, J-H Park, S Nam, H-J Lee, H-J Kim, S Yu, S-Y Shin
BACKGROUND: As mentioned in the 'Action Strategy for TB Safe Korea' in March 2017, almost 2 million Koreans were screened for latent tuberculous infection (LTBI) in 2017. As a preliminary step, the Korean Institute of Tuberculosis (KIT) screened 23 824 individuals from various population groups. The present study aimed to characterise the data collected from the screening programme using the QuantiFERON®-TB Gold In-Tube (QFT) assay. METHODS: Interferon-gamma release assays were performed using the manual QFT or automated DS2 instruments...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29663953/cost-effectiveness-of-contact-screening-strategies-for-tuberculosis-among-high-school-adolescents-in-south-korea
#5
H Sohn, H-Y Kim, S H Lee
BACKGROUND: Effective latent tuberculous infection (LTBI) control among adolescents is a critical component of tuberculosis (TB) elimination in Korea. OBJECTIVE: To compare the cost-effectiveness of the following contact screening strategies for LTBI among high-school adolescents after TB outbreaks: QuantiFERON®-TB Gold In-Tube (QFT-GIT), the tuberculin skin test (TST), or TST/QFT-GIT (two-step strategy). METHOD: The costs of post-TB outbreak screening strategies were calculated using a mixed (top-down and bottom-up) cost analysis method and expressed in 2015 US dollars...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29660203/mycobacterium-tuberculosis-active-disease-and-latent-infection-in-a-renal-transplant-cohort
#6
Nastaran Rafiei, Jackie Williams, William R Mulley, James M Trauer, Grant A Jenkin, Benjamin A Rogers
BACKGROUND: Tuberculosis (TB) is a serious opportunistic infection in renal transplant recipients associated with high mortality. Screening and treatment of latent Mycobacterium tuberculosis infection (LTBI) offers an opportunity to prevent subsequent active disease. METHODS: We retrospectively reviewed the records of all adult patients who underwent renal transplantation at our centre from 2005 to 2014 to assess current screening practices, the risks for and burden of active TB...
April 16, 2018: Nephrology
https://www.readbyqxmd.com/read/29651283/mirnas-in-tuberculosis-new-avenues-for-diagnosis-and-host-directed-therapy
#7
REVIEW
Naveed Sabir, Tariq Hussain, Syed Zahid Ali Shah, Antonio Peramo, Deming Zhao, Xiangmei Zhou
Tuberculosis (TB) is one of the most fatal infectious diseases and a leading cause of mortality, with 95% of these deaths occurring in developing countries. The causative agent, Mycobacterium tuberculosis ( Mtb ), has a well-established ability to circumvent the host's immune system for its intracellular survival. microRNAs (miRNAs) are small, non-coding RNAs having an important function at the post-transcriptional level and are involved in shaping immunity by regulating the repertoire of genes expressed in immune cells...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29650047/care-cascade-for-targeted-tuberculosis-testing-and-linkage-to-care-in-homeless-populations-in-the-united-states-a-meta-analysis
#8
Andrea Parriott, Mohsen Malekinejad, Amanda P Miller, Suzanne M Marks, Hacsi Horvath, James G Kahn
BACKGROUND: Homelessness increases the risk of tuberculosis (TB) disease and latent TB infection (LTBI), but persons experiencing homelessness often lack access to testing and treatment. We assessed the yield of TB testing and linkage to care for programs targeting homeless populations in the United States. METHODS: We conducted a comprehensive search of peer-reviewed and grey literature, adapting Cochrane systematic review methods. Two reviewers independently assessed study eligibility and abstracted key data on the testing to care cascade: number of persons reached, recruited for testing, tested for LTBI, with valid test results, referred to follow-up care, and initiating care...
April 12, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29642880/prevalence-of-latent-tuberculosis-infection-among-coal-workers-pneumoconiosis-patients-in-china-a-cross-sectional-study
#9
Yan Jin, Huanqiang Wang, Jianfang Zhang, Chunguang Ding, Ke Wen, Jingguang Fan, Tao Li
BACKGROUND: Little is known about the prevalence of latent tuberculosis infection (LTBI) among coal workers' pneumoconiosis (CWP) patients. To estimate the prevalence of LTBI and identify its associated risk factors among CWP patients. METHODS: A cross-sectional study was conducted to assess the prevalence of LTBI. Participants were screened for active TB or a history of TB by X-ray and those that underwent QuantiFERON-TB Gold In-Tube (QFT) test. A standardized questionnaire was completed and risk factors were assessed for acquiring TB...
April 11, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29622693/stratification-by-interferon-%C3%AE-release-assay-level-predicts-risk-of-incident-tb
#10
Brita Askeland Winje, Richard White, Heidi Syre, Dag Harald Skutlaberg, Fredrik Oftung, Anne Torunn Mengshoel, Hege Salvesen Blix, Arne Broch Brantsæter, Ellen Kristine Holter, Nina Handal, Gunnar Skov Simonsen, Jan Egil Afset, Anne Marte Bakken Kran
INTRODUCTION: Targeted testing and treatment of latent TB infection (LTBI) are priorities on the global health agenda, but LTBI management remains challenging. We aimed to evaluate the prognostic value of the QuantiFERON TB-Gold (QFT) test for incident TB, focusing on the interferon (IFN)-γ level, when applied in routine practice in a low TB incidence setting. METHODS: In this large population-based prospective cohort, we linked QFT results in Norway (1 January 2009-30 June 2014) with national registry data (Norwegian Surveillance System for Infectious Diseases, Norwegian Prescription Database, Norwegian Patient Registry and Statistics Norway) to assess the prognostic value of QFT for incident TB...
April 5, 2018: Thorax
https://www.readbyqxmd.com/read/29620541/screening-of-latent-tuberculosis-infection-among-health-care-workers-working-in-hajj-pilgrimage-area-in-saudi-arabia-using-interferon-gamma-release-assay-and-tuberculin-skin-test
#11
Zakeya A Bukhary, Soliman M Amer, Magdy M Emara, Mohammad E Abdalla, Sahar A Ali
BACKGROUND: Interferon gamma release assays (IGRA) is highly specific for Mycobacterium tuberculosis and is the preferred test in BCG-vaccinated individuals. The few studies that have screened health care workers (HCWs) in Saudi Arabia for latent tuberculosis infection (LTBI) using IGRA have varied in agreement with the traditional tuberculin skin test (TST). OBJECTIVE: Assess the prevalence of LTBI among HCWs working in the Hajj pilgrimage using IGRA and TST and measuring their agreement...
March 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29620426/high-rate-of-latent-tuberculosis-treatment-completion-in-immigrants-seeking-asylum-in-sweden
#12
O Olsson, N Winqvist, M Olsson, P Olsson, P Björkman
BACKGROUND/AIM: Treatment of latently infected individuals at increased risk of reactivation is a cornerstone in tuberculosis control. Although asylum seekers without residence permit in Sweden are offered screening for both active tuberculosis and latent tuberculosis infection (LTBI), treatment for LTBI is often not initiated due to anticipated low rates of treatment completion. We aimed to compare completion rates for LTBI treatment between asylum seekers and other patients, and between asylum seekers with and without residence permit...
April 5, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29602771/transcriptomic-analysis-of-cd4-t-cells-reveals-novel-immune-signatures-of-latent-tuberculosis
#13
Julie G Burel, Cecilia S Lindestam Arlehamn, Nabeela Khan, Grégory Seumois, Jason A Greenbaum, Randy Taplitz, Robert H Gilman, Mayuko Saito, Pandurangan Vijayanand, Alessandro Sette, Bjoern Peters
In the context of infectious diseases, cell population transcriptomics are useful to gain mechanistic insight into protective immune responses, which is not possible using traditional whole-blood approaches. In this study, we applied a cell population transcriptomics strategy to sorted memory CD4 T cells to define novel immune signatures of latent tuberculosis infection (LTBI) and gain insight into the phenotype of tuberculosis (TB)-specific CD4 T cells. We found a 74-gene signature that could discriminate between memory CD4 T cells from healthy latently Mycobacterium tuberculosis -infected subjects and noninfected controls...
March 30, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29590130/private-sector-tuberculosis-prevention-in-the-us-characteristics-associated-with-interferon-gamma-release-assay-or-tuberculin-skin-testing
#14
Erica L Stockbridge, Thaddeus L Miller, Erin K Carlson, Christine Ho
OBJECTIVE: To determine whether latent tuberculosis infection risk factors are associated with an increased likelihood of latent tuberculosis infection testing in the US private healthcare sector. DATA SOURCE: A national sample of medical and pharmacy claims representing services rendered January 2011 through December 2013 for 3,997,986 commercially insured individuals in the US who were 0 to 64 years of age. STUDY DESIGN: We used multivariable logistic regression models to determine whether TB/LTBI risk factors were associated with an increased likelihood of Interferon-Gamma Release Assay (IGRA) or Tuberculin Skin Test (TST) testing in the private sector...
2018: PloS One
https://www.readbyqxmd.com/read/29589578/universal-screening-for-latent-and-active-tuberculosis-tb-in-asylum-seeking-children-bochum-and-hamburg-germany-september-2015-to-november-2016
#15
Maya Mueller-Hermelink, Robin Kobbe, Benedikt Methling, Cornelius Rau, Ulf Schulze-Sturm, Isa Auer, Frank Ahrens, Folke Brinkmann
BackgroundIn Germany, the incidence of tuberculosis (TB) in children has been on the rise since 2009. High numbers of foreign-born asylum seekers have contributed considerably to the disease burden. Therefore, effective screening strategies for latent TB infection (LTBI) and active TB in asylum seeking children are needed. Aim: Our aim was to investigate the prevalence of LTBI and active TB in asylum seeking children up to 15 years of age in two geographic regions in Germany. Methods: Screening for TB was performed in children in asylum seeker reception centres by tuberculin skin test (TST) or interferon gamma release assay (IGRA)...
March 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29577042/physicians-perspectives-on-communication-and-decision-making-in-clinical-encounters-for-treatment-of-latent-tuberculosis-infection
#16
Claudia C Dobler, Sinthia Bosnic-Anticevich, Carol L Armour
The aim of the study was to explore the views of tuberculosis (TB) physicians on treatment of latent TB infection (LTBI), focusing on decision making and communication in clinical practice. 20 Australian TB physicians participated in a semistructured interview in person or over the telephone. Interviews were recorded, transcribed and analysed thematically. The study identified challenges that physicians face when discussing treatment for LTBI with patients. These included difficulties explaining the concept of latency (in particular to patients from culturally and linguistically diverse backgrounds) and providing guidance to patients while still framing treatment decisions as a choice...
January 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29573031/a-systematic-review-of-adverse-events-of-rifapentine-and-isoniazid-compared-to-other-treatments-for-latent-tuberculosis-infection
#17
REVIEW
Christopher Pease, Brian Hutton, Fatemeh Yazdi, Dianna Wolfe, Candyce Hamel, Pauline Barbeau, Becky Skidmore, Gonzalo G Alvarez
PURPOSE: Tuberculosis (TB) remains a common cause of death globally. A regimen of 12 doses of isoniazid (INH) and rifapentine given once weekly (INH/RPT-3) has recently been recommended by the World Health Organization for the treatment of latent TB infection (LTBI). We aimed to determine whether the INH/RPT-3 regimen had similar or lesser rates of adverse events compared to other LTBI regimens, namely INH for 9 months, INH for 6 months, rifampin for 3 to 4 months, and rifampin plus INH for 3 to 4 months...
March 23, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29567507/acceptability-of-latent-tuberculosis-testing-of-migrants-in-a-college-environment-in-england
#18
C-L Walker, K Duffield, H Kaur, M Dedicoat, R Gajraj
OBJECTIVES: The majority of tuberculosis (TB) cases in England occur from reactivation of latent tuberculosis infection (LTBI) in the settled migrant population. The National Institute for Health and Clinical Excellence recommends that new entrants from high-incidence countries are screened to detect LTBI. This article seeks to describe an outreach programme and testing for LTBI in an innovative setting-ESOL (English for Speakers of Other Languages) classes at a community college (CC) with evaluation of acceptability...
March 19, 2018: Public Health
https://www.readbyqxmd.com/read/29565838/tuberculosis-united-states-2017
#19
Rebekah J Stewart, Clarisse A Tsang, Robert H Pratt, Sandy F Price, Adam J Langer
In 2017, a total of 9,093 new cases of tuberculosis (TB) were provisionally* reported in the United States, representing an incidence rate of 2.8 cases per 100,000 population. The case count decreased by 1.8% from 2016 to 2017, and the rate declined by 2.5% over the same period. These decreases are consistent with the slight decline in TB seen over the past several years (1). This report summarizes provisional TB surveillance data reported to CDC's National Tuberculosis Surveillance System for 2017 and in the last decade...
March 23, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29562981/low-body-mass-index-and-latent-tuberculous-infection-a-systematic-review-and-meta-analysis
#20
L A Saag, M P LaValley, N S Hochberg, J P Cegielski, J A Pleskunas, B P Linas, C R Horsburgh
BACKGROUND: The well-documented association between underweight and increased incidence of active tuberculosis (TB) has not been extended to incidence or prevalence of latent tuberculous infection (LTBI). DESIGN: After identifying studies that reported a categorical measure of body mass index (BMI) and used the tuberculin skin test (TST) or QuantiFERON®-TB Gold In-Tube (QFT) to measure LTBI, a maximum likelihood random-effects model was used to examine the pooled association between LTBI and low BMI (<18...
April 1, 2018: International Journal of Tuberculosis and Lung Disease
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